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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-496 ABCA13 0.55 0.60838 1.28 0.26041 miRanda -0.29 0.0197 NA
2 hsa-miR-543 ABCA13 -0.29 0.65642 1.28 0.26041 miRanda -0.44 0.00099 NA
3 hsa-miR-496 ACOT9 0.55 0.60838 -0.92 0.7285 miRanda -0.22 0 NA
4 hsa-miR-496 ACSM1 0.55 0.60838 -0.69 0.40934 miRanda -0.31 0.00051 NA
5 hsa-miR-543 ACSM3 -0.29 0.65642 -0.23 0.89918 miRanda -0.19 0.02145 NA
6 hsa-miR-543 ACSS1 -0.29 0.65642 -1.32 0.64713 miRanda -0.19 0.00532 NA
7 hsa-miR-543 ACTG2 -0.29 0.65642 0.03 0.98974 miRanda -0.36 0.01279 NA
8 hsa-miR-496 ACTR3 0.55 0.60838 -0.76 0.84655 miRanda -0.1 0.00028 NA
9 hsa-miR-496 ADAM28 0.55 0.60838 -1.46 0.61423 miRanda -0.43 1.0E-5 NA
10 hsa-miR-543 ADAM28 -0.29 0.65642 -1.46 0.61423 miRanda -0.52 0 NA
11 hsa-miR-543 ADAM9 -0.29 0.65642 -0.36 0.92876 miRanda -0.2 0.00126 NA
12 hsa-miR-496 ADAMTS6 0.55 0.60838 -0.6 0.59783 miRanda -0.23 0.00039 NA
13 hsa-miR-496 ADAMTSL5 0.55 0.60838 0.17 0.90384 miRanda -0.44 0 NA
14 hsa-miR-543 ADAT2 -0.29 0.65642 -0.42 0.76827 miRanda -0.11 0.01486 NA
15 hsa-miR-543 ADD3 -0.29 0.65642 -0.44 0.90001 miRanda -0.13 0.0027 NA
16 hsa-miR-496 ADORA2B 0.55 0.60838 1.45 0.33396 miRanda -0.15 0.03225 NA
17 hsa-miR-543 ADSS -0.29 0.65642 0.2 0.94898 miRanda -0.13 2.0E-5 NA
18 hsa-miR-543 AFAP1L2 -0.29 0.65642 -0.63 0.81741 miRanda -0.23 0.00015 NA
19 hsa-miR-496 AGMAT 0.55 0.60838 0.11 0.91872 miRanda -0.16 0.03277 NA
20 hsa-miR-543 AGR2 -0.29 0.65642 4.07 0.36748 miRanda -0.81 0 NA
21 hsa-miR-543 AGR3 -0.29 0.65642 1.7 0.52011 miRanda -0.69 1.0E-5 NA
22 hsa-miR-543 AHNAK -0.29 0.65642 -0.09 0.98554 miRanda -0.15 0.00219 NA
23 hsa-miR-375 AHR 3.94 0.60651 -0.01 0.99721 miRanda -0.1 0.00054 NA
24 hsa-miR-496 AHR 0.55 0.60838 -0.01 0.99721 miRanda -0.13 0.00786 NA
25 hsa-miR-543 AHR -0.29 0.65642 -0.01 0.99721 miRanda -0.2 0.00019 NA
26 hsa-miR-543 AIM1 -0.29 0.65642 -1.12 0.69647 miRanda -0.21 0.00586 NA
27 hsa-miR-543 AIM1L -0.29 0.65642 1.83 0.35987 miRanda -0.73 0 NA
28 hsa-miR-543 AKAP5 -0.29 0.65642 -1.34 0.20418 miRanda -0.13 0.02031 NA
29 hsa-miR-496 ALG3 0.55 0.60838 0.42 0.88028 miRanda -0.17 0 NA
30 hsa-miR-375 ANKRD1 3.94 0.60651 -1.65 0.22181 miRNAWalker2 validate -0.34 3.0E-5 NA
31 hsa-miR-543 ANO6 -0.29 0.65642 -0.6 0.86077 miRanda -0.11 0.01691 NA
32 hsa-miR-543 ANTXR1 -0.29 0.65642 -0.72 0.85999 miRanda -0.18 0.03347 NA
33 hsa-miR-543 ANXA2P3 -0.29 0.65642 -1.19 0.20049 miRanda -0.23 0.00749 NA
34 hsa-miR-496 ANXA4 0.55 0.60838 -0.24 0.95893 miRanda -0.23 0.00158 NA
35 hsa-miR-496 APBB1IP 0.55 0.60838 -2.51 0.20132 miRanda -0.17 0.03618 NA
36 hsa-miR-543 AQP9 -0.29 0.65642 -2.92 0.0592 miRanda -0.31 0.00705 NA
37 hsa-miR-375 ARAP2 3.94 0.60651 -0.75 0.76433 miRanda -0.13 3.0E-5 NA
38 hsa-miR-375 ARHGAP11A 3.94 0.60651 0.46 0.80083 miRNAWalker2 validate -0.13 1.0E-5 NA
39 hsa-miR-496 ARHGAP11A 0.55 0.60838 0.46 0.80083 miRanda -0.17 0.00062 NA
40 hsa-miR-543 ARHGAP11B -0.29 0.65642 -0.29 0.66969 miRanda -0.19 0.01267 NA
41 hsa-miR-543 ARHGAP12 -0.29 0.65642 0.06 0.98334 miRanda -0.12 0.00205 NA
42 hsa-miR-543 ARHGAP26 -0.29 0.65642 -0.4 0.89387 MirTarget -0.23 4.0E-5 NA
43 hsa-miR-496 ARHGAP27 0.55 0.60838 -0.4 0.90004 miRanda -0.28 0 NA
44 hsa-miR-543 ARHGAP32 -0.29 0.65642 0.77 0.80338 miRanda -0.19 0.00013 NA
45 hsa-miR-543 ARHGAP6 -0.29 0.65642 0.01 0.99291 miRanda -0.17 0.00954 NA
46 hsa-miR-375 ARHGDIB 3.94 0.60651 -1.53 0.67706 miRanda -0.1 0.00041 NA
47 hsa-miR-543 ARHGEF2 -0.29 0.65642 -0.51 0.87953 miRanda -0.19 0 NA
48 hsa-miR-375 ARL14 3.94 0.60651 0.61 0.81063 miRanda -0.23 0.00681 NA
49 hsa-miR-543 ARL14 -0.29 0.65642 0.61 0.81063 miRanda -0.91 0 NA
50 hsa-miR-375 ARL4C 3.94 0.60651 -1.24 0.72021 MirTarget -0.24 0 NA
51 hsa-miR-543 ARMC10 -0.29 0.65642 0.08 0.97417 miRanda -0.11 5.0E-5 NA
52 hsa-miR-375 ARNTL2 3.94 0.60651 0.05 0.97673 miRNAWalker2 validate -0.15 9.0E-5 NA
53 hsa-miR-543 ARPC1B -0.29 0.65642 -0.87 0.83457 miRanda -0.15 0.00019 NA
54 hsa-miR-496 ASAP2 0.55 0.60838 0.83 0.79826 MirTarget; miRanda -0.11 0.0381 NA
55 hsa-miR-543 ASAP2 -0.29 0.65642 0.83 0.79826 miRanda -0.21 9.0E-5 NA
56 hsa-miR-543 ASF1B -0.29 0.65642 0.26 0.89226 miRanda -0.26 5.0E-5 NA
57 hsa-miR-543 ASPH -0.29 0.65642 0.46 0.90891 miRanda -0.17 0.00504 NA
58 hsa-miR-543 ASPN -0.29 0.65642 0.21 0.94844 miRanda -0.24 0.01215 NA
59 hsa-miR-543 ATF7IP2 -0.29 0.65642 -1.06 0.53248 miRanda -0.26 4.0E-5 NA
60 hsa-miR-375 ATP10A 3.94 0.60651 -0.6 0.77679 miRanda -0.16 1.0E-5 NA
61 hsa-miR-543 ATP10A -0.29 0.65642 -0.6 0.77679 miRanda -0.15 0.02231 NA
62 hsa-miR-496 ATP10B 0.55 0.60838 0.12 0.9634 miRanda -0.54 0.00033 NA
63 hsa-miR-543 ATP11B -0.29 0.65642 -0.31 0.92367 miRanda -0.14 0.00019 NA
64 hsa-miR-543 ATP6V0D2 -0.29 0.65642 -2.18 0.00523 miRanda -0.3 0.00118 NA
65 hsa-miR-496 AVL9 0.55 0.60838 0.07 0.97309 miRanda -0.11 0.00245 NA
66 hsa-miR-543 AVL9 -0.29 0.65642 0.07 0.97309 MirTarget; miRanda -0.14 0.00014 NA
67 hsa-miR-375 AXL 3.94 0.60651 -0.68 0.83324 miRNAWalker2 validate -0.17 0 NA
68 hsa-miR-543 B2M -0.29 0.65642 -0.63 0.91369 miRanda -0.13 0.00087 NA
69 hsa-miR-543 B3GNT5 -0.29 0.65642 0.43 0.87244 miRanda -0.17 0.00292 NA
70 hsa-miR-543 B3GNT6 -0.29 0.65642 0.67 0.72571 miRanda -0.87 0.00015 NA
71 hsa-miR-496 BAIAP2L1 0.55 0.60838 1.27 0.71967 miRanda -0.15 0.02439 NA
72 hsa-miR-543 BARX2 -0.29 0.65642 -0.6 0.77231 miRanda -0.47 9.0E-5 NA
73 hsa-miR-375 BAZ1A 3.94 0.60651 -0.9 0.7528 miRNAWalker2 validate -0.11 0 NA
74 hsa-miR-543 BAZ1A -0.29 0.65642 -0.9 0.7528 miRanda -0.15 0.00065 NA
75 hsa-miR-375 BCL11B 3.94 0.60651 -1.34 0.42572 miRanda -0.11 0.01666 NA
76 hsa-miR-375 BCL2L14 3.94 0.60651 -0.38 0.81716 miRanda -0.2 0.00408 NA
77 hsa-miR-496 BCL2L14 0.55 0.60838 -0.38 0.81716 miRanda -0.69 0 NA
78 hsa-miR-543 BCL2L14 -0.29 0.65642 -0.38 0.81716 miRanda -0.76 0 NA
79 hsa-miR-375 BCL6 3.94 0.60651 -0.92 0.7625 miRanda -0.14 0 NA
80 hsa-miR-543 BCL6 -0.29 0.65642 -0.92 0.7625 MirTarget; miRanda -0.12 0.01083 NA
81 hsa-miR-543 BDNF -0.29 0.65642 0.42 0.57837 miRanda -0.18 0.03626 NA
82 hsa-miR-543 BHLHE40 -0.29 0.65642 0.24 0.95761 miRanda -0.16 0.01932 NA
83 hsa-miR-543 BID -0.29 0.65642 -0.12 0.96368 miRanda -0.1 0.00802 NA
84 hsa-miR-496 BIN3 0.55 0.60838 0.11 0.96472 miRanda -0.1 0.00273 NA
85 hsa-miR-375 BIRC3 3.94 0.60651 -1.99 0.54256 miRNAWalker2 validate -0.28 0 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization
86 hsa-miR-375 BIRC5 3.94 0.60651 0.4 0.79598 miRanda -0.27 0 NA
87 hsa-miR-543 BRI3 -0.29 0.65642 -0.14 0.96667 miRanda -0.12 0.00056 NA
88 hsa-miR-496 BTNL3 0.55 0.60838 -1.79 0.37933 miRanda -0.48 0.02633 NA
89 hsa-miR-543 BUB1 -0.29 0.65642 -0.03 0.98544 miRanda -0.31 9.0E-5 NA
90 hsa-miR-543 BUB1B -0.29 0.65642 0.31 0.84796 miRanda -0.21 0.00376 NA
91 hsa-miR-496 BZW2 0.55 0.60838 0.15 0.96074 miRanda -0.15 1.0E-5 NA
92 hsa-miR-543 BZW2 -0.29 0.65642 0.15 0.96074 miRanda -0.17 1.0E-5 NA
93 hsa-miR-543 C1GALT1 -0.29 0.65642 0.86 0.72994 MirTarget -0.1 0.02263 NA
94 hsa-miR-543 CAB39 -0.29 0.65642 -0.23 0.94628 MirTarget; miRanda -0.11 0.00016 NA
95 hsa-miR-375 CALU 3.94 0.60651 -0.07 0.98593 miRNAWalker2 validate -0.13 0 NA
96 hsa-miR-543 CAMK2N1 -0.29 0.65642 1.67 0.64627 miRanda -0.15 0.00572 NA
97 hsa-miR-543 CAP1 -0.29 0.65642 -0.58 0.89508 miRanda -0.13 0.00033 NA
98 hsa-miR-496 CAPG 0.55 0.60838 -1.57 0.69914 miRanda -0.46 0 NA
99 hsa-miR-496 CARD14 0.55 0.60838 0.14 0.87137 miRanda -0.24 0.00091 NA
100 hsa-miR-543 CARD14 -0.29 0.65642 0.14 0.87137 miRanda -0.33 2.0E-5 NA
101 hsa-miR-496 CASP4 0.55 0.60838 -0.96 0.75012 miRanda -0.2 0 NA
102 hsa-miR-543 CASP4 -0.29 0.65642 -0.96 0.75012 miRanda -0.2 0 NA
103 hsa-miR-543 CASP7 -0.29 0.65642 -0.23 0.93464 miRanda -0.16 6.0E-5 NA
104 hsa-miR-543 CASP8 -0.29 0.65642 -1.07 0.67507 miRanda -0.23 1.0E-5 NA
105 hsa-miR-543 CAST -0.29 0.65642 -0 0.99966 miRanda -0.13 0.00026 NA
106 hsa-miR-543 CBLB -0.29 0.65642 -0.67 0.79551 miRanda -0.11 0.00076 NA
107 hsa-miR-496 CCDC84 0.55 0.60838 -0.16 0.91539 miRanda -0.12 0.01041 NA
108 hsa-miR-375 CCDC88B 3.94 0.60651 -1.59 0.5288 miRNAWalker2 validate -0.16 1.0E-5 NA
109 hsa-miR-543 CCDC88C -0.29 0.65642 -1.33 0.61736 miRanda -0.25 4.0E-5 NA
110 hsa-miR-543 CCK -0.29 0.65642 2.35 0.15308 miRanda -0.78 5.0E-5 NA
111 hsa-miR-543 CCL11 -0.29 0.65642 -0.72 0.509 miRanda -0.32 0.00456 NA
112 hsa-miR-496 CCL20 0.55 0.60838 -0.66 0.76681 miRanda -0.62 1.0E-5 NA
113 hsa-miR-543 CCL22 -0.29 0.65642 -1.79 0.28612 miRanda -0.42 0.00052 NA
114 hsa-miR-496 CCL28 0.55 0.60838 -2.18 0.2159 miRanda -0.34 0.00093 NA
115 hsa-miR-496 CCNB1 0.55 0.60838 0.85 0.7071 miRanda -0.13 0.0144 NA
116 hsa-miR-543 CCNB1 -0.29 0.65642 0.85 0.7071 miRanda -0.14 0.01214 NA
117 hsa-miR-543 CCNF -0.29 0.65642 0.14 0.93342 miRanda -0.14 0.00354 NA
118 hsa-miR-543 CCNI2 -0.29 0.65642 -0.19 0.84244 miRanda -0.34 1.0E-5 NA
119 hsa-miR-496 CD2AP 0.55 0.60838 0.05 0.98919 miRanda -0.1 0.01373 NA
120 hsa-miR-543 CD2AP -0.29 0.65642 0.05 0.98919 miRanda -0.19 3.0E-5 NA
121 hsa-miR-543 CD300LF -0.29 0.65642 -2.84 0.04531 miRanda -0.18 0.04524 NA
122 hsa-miR-543 CD55 -0.29 0.65642 0.55 0.89013 miRanda -0.3 8.0E-5 NA
123 hsa-miR-496 CD72 0.55 0.60838 -2.48 0.10288 miRanda -0.17 0.03696 NA
124 hsa-miR-496 CDCA7 0.55 0.60838 -0.05 0.98348 miRanda -0.66 0 NA
125 hsa-miR-543 CDCA7 -0.29 0.65642 -0.05 0.98348 miRanda -0.7 0 NA
126 hsa-miR-375 CDCA7L 3.94 0.60651 -1 0.6638 miRNAWalker2 validate -0.2 0 NA
127 hsa-miR-496 CDCP1 0.55 0.60838 1.44 0.67986 miRanda -0.15 0.01447 NA
128 hsa-miR-543 CDH11 -0.29 0.65642 -1.41 0.68344 miRanda -0.28 0.0034 NA
129 hsa-miR-543 CDH17 -0.29 0.65642 1.99 0.44607 miRanda -0.46 0.00539 NA
130 hsa-miR-543 CDHR5 -0.29 0.65642 2.66 0.31323 miRanda -0.47 0.0013 NA
131 hsa-miR-375 CDK1 3.94 0.60651 0.33 0.87769 miRanda -0.22 0 NA
132 hsa-miR-496 CDK1 0.55 0.60838 0.33 0.87769 miRanda -0.27 3.0E-5 NA
133 hsa-miR-543 CDK1 -0.29 0.65642 0.33 0.87769 miRanda -0.3 2.0E-5 NA
134 hsa-miR-375 CDK2 3.94 0.60651 -0.46 0.84811 miRanda -0.12 0 NA
135 hsa-miR-496 CENPE 0.55 0.60838 0.08 0.95983 miRanda -0.21 0.00136 NA
136 hsa-miR-543 CENPE -0.29 0.65642 0.08 0.95983 miRanda -0.21 0.00363 NA
137 hsa-miR-375 CENPF 3.94 0.60651 0.53 0.8336 miRNAWalker2 validate -0.25 0 NA
138 hsa-miR-543 CENPI -0.29 0.65642 0.31 0.67033 miRanda -0.27 0.0015 NA
139 hsa-miR-543 CENPW -0.29 0.65642 0 0.99953 miRanda -0.15 0.00956 NA
140 hsa-miR-543 CEP55 -0.29 0.65642 0.07 0.97056 miRanda -0.42 0 NA
141 hsa-miR-543 CES2 -0.29 0.65642 0.48 0.88344 miRanda -0.11 0.04098 NA
142 hsa-miR-543 CFL1 -0.29 0.65642 -0.37 0.94146 miRanda -0.12 0.00013 NA
143 hsa-miR-543 CFLAR -0.29 0.65642 -0.66 0.83109 miRanda -0.15 6.0E-5 NA
144 hsa-miR-543 CFTR -0.29 0.65642 -1.12 0.77039 miRanda -0.65 0.00222 NA
145 hsa-miR-543 CGN -0.29 0.65642 2.1 0.56692 miRanda -0.33 6.0E-5 NA
146 hsa-miR-543 CHML -0.29 0.65642 -0.35 0.86584 miRanda -0.15 0.00123 NA
147 hsa-miR-543 CHMP2B -0.29 0.65642 -0.04 0.98959 miRanda -0.12 0.00017 NA
148 hsa-miR-543 CHMP4C -0.29 0.65642 0.82 0.73264 miRanda -0.26 2.0E-5 NA
149 hsa-miR-496 CHST4 0.55 0.60838 -0.95 0.69336 miRanda -0.52 0.0004 NA
150 hsa-miR-496 CLCN1 0.55 0.60838 0.85 0.48863 miRanda -0.43 0.00135 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 144 1518 7.599e-27 3.536e-23
2 ORGAN MORPHOGENESIS 89 841 1.372e-19 3.192e-16
3 EPITHELIUM DEVELOPMENT 94 945 7.924e-19 1.229e-15
4 EMBRYO DEVELOPMENT 90 894 2.206e-18 2.566e-15
5 TISSUE MORPHOGENESIS 59 533 3.912e-14 3.641e-11
6 REGULATION OF CELL PROLIFERATION 113 1496 1.102e-13 8.545e-11
7 EMBRYONIC MORPHOGENESIS 58 539 2.196e-13 1.46e-10
8 EMBRYONIC ORGAN DEVELOPMENT 47 406 3.451e-12 2.007e-09
9 REPRODUCTIVE SYSTEM DEVELOPMENT 47 408 4.113e-12 2.127e-09
10 POSITIVE REGULATION OF MOLECULAR FUNCTION 123 1791 5.808e-12 2.678e-09
11 TUBE DEVELOPMENT 56 552 6.332e-12 2.678e-09
12 RESPONSE TO CYTOKINE 65 714 1.506e-11 5.841e-09
13 REGULATION OF STEM CELL DIFFERENTIATION 23 113 1.829e-11 6.547e-09
14 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 54 554 7.002e-11 2.327e-08
15 EPITHELIAL CELL DIFFERENTIATION 50 495 1.041e-10 3.229e-08
16 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 121 1848 1.93e-10 5.612e-08
17 TUBE MORPHOGENESIS 38 323 2.645e-10 7.239e-08
18 MORPHOGENESIS OF AN EPITHELIUM 43 400 3.171e-10 8.196e-08
19 REGULATION OF CELLULAR COMPONENT MOVEMENT 65 771 3.894e-10 9.537e-08
20 CYTOKINE MEDIATED SIGNALING PATHWAY 46 452 4.652e-10 1.082e-07
21 IMMUNE SYSTEM PROCESS 126 1984 5.309e-10 1.142e-07
22 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 22 122 5.89e-10 1.142e-07
23 SKELETAL SYSTEM DEVELOPMENT 46 455 5.774e-10 1.142e-07
24 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 111 1672 5.668e-10 1.142e-07
25 REGULATION OF CELL DEATH 101 1472 6.603e-10 1.229e-07
26 GLAND DEVELOPMENT 42 395 7.16e-10 1.281e-07
27 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 97 1395 7.53e-10 1.298e-07
28 CELL DIVISION 46 460 8.239e-10 1.322e-07
29 POSITIVE REGULATION OF CATALYTIC ACTIVITY 103 1518 8.055e-10 1.322e-07
30 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 19 93 9.754e-10 1.513e-07
31 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 74 957 1.106e-09 1.66e-07
32 POSITIVE REGULATION OF RESPONSE TO STIMULUS 122 1929 1.366e-09 1.987e-07
33 STEM CELL DIFFERENTIATION 27 190 1.759e-09 2.48e-07
34 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 83 1142 1.922e-09 2.63e-07
35 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 14 50 1.992e-09 2.648e-07
36 GLAND MORPHOGENESIS 19 97 2.064e-09 2.668e-07
37 REGULATION OF CELL DIFFERENTIATION 100 1492 2.825e-09 3.552e-07
38 RESPONSE TO LIPID 69 888 3.452e-09 4.227e-07
39 POSITIVE REGULATION OF LOCOMOTION 42 420 4.541e-09 5.417e-07
40 MITOTIC NUCLEAR DIVISION 38 361 6.182e-09 7.016e-07
41 SKELETAL SYSTEM MORPHOGENESIS 27 201 6.133e-09 7.016e-07
42 LOCOMOTION 80 1114 6.645e-09 7.361e-07
43 POSITIVE REGULATION OF CELL COMMUNICATION 100 1532 1.109e-08 1.2e-06
44 EMBRYONIC ORGAN MORPHOGENESIS 32 279 1.281e-08 1.354e-06
45 CELLULAR RESPONSE TO CYTOKINE STIMULUS 52 606 1.336e-08 1.382e-06
46 CARDIOVASCULAR SYSTEM DEVELOPMENT 62 788 1.422e-08 1.408e-06
47 CIRCULATORY SYSTEM DEVELOPMENT 62 788 1.422e-08 1.408e-06
48 POSITIVE REGULATION OF HYDROLASE ACTIVITY 68 905 1.725e-08 1.672e-06
49 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 105 1656 2.072e-08 1.967e-06
50 REGULATION OF CYTOKINE PRODUCTION 49 563 2.269e-08 2.084e-06
51 REGULATION OF HYDROLASE ACTIVITY 89 1327 2.285e-08 2.084e-06
52 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 51 602 2.803e-08 2.508e-06
53 MITOTIC SISTER CHROMATID SEGREGATION 17 91 3.056e-08 2.683e-06
54 SISTER CHROMATID SEGREGATION 24 176 3.173e-08 2.684e-06
55 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 86 1275 3.138e-08 2.684e-06
56 RESPONSE TO OXYGEN CONTAINING COMPOUND 91 1381 3.575e-08 2.919e-06
57 ENDODERM DEVELOPMENT 15 71 3.521e-08 2.919e-06
58 CELL DEVELOPMENT 93 1426 4.047e-08 3.246e-06
59 POSITIVE REGULATION OF CELL PROLIFERATION 62 814 4.684e-08 3.694e-06
60 CELL PROLIFERATION 54 672 6.37e-08 4.94e-06
61 REPRODUCTION 86 1297 6.736e-08 5.138e-06
62 ORGANELLE FISSION 44 496 6.958e-08 5.222e-06
63 POSITIVE REGULATION OF CELL DEATH 50 605 8.377e-08 6.187e-06
64 CHROMOSOME SEGREGATION 30 272 8.789e-08 6.39e-06
65 FORMATION OF PRIMARY GERM LAYER 18 110 1.02e-07 7.304e-06
66 DIGESTIVE SYSTEM DEVELOPMENT 21 148 1.148e-07 8.096e-06
67 INFLAMMATORY RESPONSE 41 454 1.208e-07 8.388e-06
68 MESENCHYME DEVELOPMENT 24 190 1.392e-07 9.523e-06
69 ENDODERM FORMATION 12 50 1.866e-07 1.244e-05
70 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 69 983 1.871e-07 1.244e-05
71 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 108 1805 2.474e-07 1.622e-05
72 VASCULATURE DEVELOPMENT 41 469 2.889e-07 1.867e-05
73 NUCLEAR CHROMOSOME SEGREGATION 26 228 3.302e-07 2.105e-05
74 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 32 321 3.395e-07 2.135e-05
75 IMMUNE RESPONSE 74 1100 3.468e-07 2.152e-05
76 MESENCHYMAL CELL DIFFERENTIATION 19 134 4.629e-07 2.834e-05
77 POSITIVE REGULATION OF GENE EXPRESSION 103 1733 6.718e-07 4.06e-05
78 RESPONSE TO EXTERNAL STIMULUS 107 1821 6.816e-07 4.066e-05
79 ACTIN FILAMENT BASED PROCESS 39 450 7.007e-07 4.127e-05
80 EPIDERMIS DEVELOPMENT 27 253 7.436e-07 4.325e-05
81 ANTERIOR POSTERIOR PATTERN SPECIFICATION 23 194 7.896e-07 4.536e-05
82 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 68 1004 8.42e-07 4.778e-05
83 RESPONSE TO WOUNDING 45 563 9.467e-07 5.275e-05
84 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND DEVELOPMENT 6 11 9.523e-07 5.275e-05
85 DIGESTIVE TRACT MORPHOGENESIS 11 48 9.997e-07 5.473e-05
86 NEGATIVE REGULATION OF CELL DEATH 61 872 1.116e-06 6.039e-05
87 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 24 213 1.156e-06 6.182e-05
88 CELL MOTILITY 59 835 1.223e-06 6.395e-05
89 LOCALIZATION OF CELL 59 835 1.223e-06 6.395e-05
90 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 61 876 1.297e-06 6.705e-05
91 ENDODERMAL CELL DIFFERENTIATION 10 40 1.318e-06 6.739e-05
92 ODONTOGENESIS 16 105 1.396e-06 7.058e-05
93 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 68 1021 1.521e-06 7.608e-05
94 REGIONALIZATION 30 311 1.566e-06 7.754e-05
95 DEFENSE RESPONSE 78 1231 1.708e-06 8.365e-05
96 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 15 95 1.874e-06 9.085e-05
97 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 25 1.987e-06 9.533e-05
98 RESPONSE TO ENDOGENOUS STIMULUS 88 1450 2.093e-06 9.936e-05
99 PATTERN SPECIFICATION PROCESS 36 418 2.168e-06 0.0001019
100 BIOLOGICAL ADHESION 68 1032 2.205e-06 0.0001026
101 SENSORY ORGAN DEVELOPMENT 40 493 2.646e-06 0.0001218
102 POSITIVE REGULATION OF TRANSPORT 63 936 2.67e-06 0.0001218
103 RESPONSE TO ORGANIC CYCLIC COMPOUND 62 917 2.781e-06 0.0001256
104 CELL DEATH 66 1001 3.067e-06 0.0001372
105 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 56 801 3.176e-06 0.0001407
106 ZYMOGEN ACTIVATION 16 112 3.34e-06 0.0001466
107 REGULATION OF IMMUNE SYSTEM PROCESS 85 1403 3.402e-06 0.000148
108 MORPHOGENESIS OF A BRANCHING STRUCTURE 20 167 3.496e-06 0.0001506
109 HEART MORPHOGENESIS 23 212 3.678e-06 0.000157
110 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 59 867 4.001e-06 0.0001693
111 APPENDAGE DEVELOPMENT 20 169 4.202e-06 0.0001715
112 HEART DEVELOPMENT 38 466 4.177e-06 0.0001715
113 CRANIAL SKELETAL SYSTEM DEVELOPMENT 11 55 4.188e-06 0.0001715
114 LIMB DEVELOPMENT 20 169 4.202e-06 0.0001715
115 BLOOD VESSEL MORPHOGENESIS 32 364 5.171e-06 0.0002068
116 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 12 67 5.2e-06 0.0002068
117 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 10 46 5.192e-06 0.0002068
118 CARDIAC CHAMBER MORPHOGENESIS 15 104 5.965e-06 0.0002352
119 SEX DIFFERENTIATION 26 266 6.065e-06 0.0002372
120 RESPONSE TO ABIOTIC STIMULUS 66 1024 6.494e-06 0.0002518
121 RESPONSE TO OXIDATIVE STRESS 31 352 6.984e-06 0.0002686
122 POSITIVE REGULATION OF CELL DIFFERENTIATION 56 823 7.107e-06 0.0002711
123 REGULATION OF EPITHELIAL CELL PROLIFERATION 27 285 7.224e-06 0.0002733
124 REGULATION OF CELL ADHESION 46 629 7.791e-06 0.0002924
125 REGULATION OF CELL CYCLE 62 949 8.241e-06 0.0003068
126 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 49 689 8.403e-06 0.0003103
127 TAXIS 37 464 9.247e-06 0.0003388
128 REGULATION OF CYTOSKELETON ORGANIZATION 39 502 9.777e-06 0.0003554
129 POSITIVE REGULATION OF LEUKOCYTE MIGRATION 15 109 1.071e-05 0.0003841
130 REGULATION OF ORGAN MORPHOGENESIS 24 242 1.073e-05 0.0003841
131 REGULATION OF CHEMOTAXIS 20 180 1.095e-05 0.0003888
132 MUSCLE STRUCTURE DEVELOPMENT 35 432 1.145e-05 0.0004036
133 CHROMOSOME CONDENSATION 8 31 1.192e-05 0.000417
134 WOUND HEALING 37 470 1.231e-05 0.0004274
135 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 18 153 1.364e-05 0.00047
136 PROSTATE GLAND DEVELOPMENT 9 41 1.418e-05 0.0004852
137 POSITIVE REGULATION OF DNA REPLICATION 13 86 1.471e-05 0.0004997
138 CARDIAC MUSCLE TISSUE DEVELOPMENT 17 140 1.548e-05 0.000522
139 MITOTIC CELL CYCLE 52 766 1.617e-05 0.0005414
140 GASTRULATION 18 155 1.631e-05 0.0005422
141 NEGATIVE REGULATION OF CELL DIFFERENTIATION 44 609 1.654e-05 0.0005458
142 TISSUE REMODELING 13 87 1.672e-05 0.000548
143 RESPONSE TO TUMOR NECROSIS FACTOR 23 233 1.756e-05 0.0005714
144 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 38 498 1.896e-05 0.0006127
145 CELL CYCLE 78 1316 1.927e-05 0.0006184
146 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 8 33 1.966e-05 0.0006205
147 OSSIFICATION 24 251 1.974e-05 0.0006205
148 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 80 1360 1.955e-05 0.0006205
149 EPITHELIAL CELL PROLIFERATION 13 89 2.148e-05 0.0006708
150 REGULATION OF CELL CYCLE PROCESS 41 558 2.174e-05 0.0006745
151 REGULATION OF CELL DEVELOPMENT 55 836 2.228e-05 0.0006864
152 CARDIAC CHAMBER DEVELOPMENT 17 144 2.245e-05 0.0006873
153 REGULATION OF PEPTIDASE ACTIVITY 32 392 2.323e-05 0.0007066
154 REGULATION OF MUSCLE TISSUE DEVELOPMENT 14 103 2.415e-05 0.000725
155 REGULATION OF MUSCLE ORGAN DEVELOPMENT 14 103 2.415e-05 0.000725
156 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 8 34 2.488e-05 0.0007422
157 BODY MORPHOGENESIS 9 44 2.6e-05 0.0007685
158 REGULATION OF CELL DIVISION 25 272 2.609e-05 0.0007685
159 CARTILAGE DEVELOPMENT 17 147 2.938e-05 0.0008599
160 CELL CHEMOTAXIS 18 162 2.978e-05 0.0008606
161 RESPONSE TO BIOTIC STIMULUS 57 886 2.977e-05 0.0008606
162 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 47 684 3.064e-05 0.0008801
163 EPITHELIAL TO MESENCHYMAL TRANSITION 10 56 3.255e-05 0.0009236
164 NEUROGENESIS 81 1402 3.254e-05 0.0009236
165 REGULATION OF CELLULAR COMPONENT BIOGENESIS 51 767 3.368e-05 0.0009497
166 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 19 179 3.433e-05 0.0009572
167 POSITIVE REGULATION OF CHEMOTAXIS 15 120 3.435e-05 0.0009572
168 REGULATION OF DNA BINDING 13 93 3.466e-05 0.0009599
169 REGULATION OF LEUKOCYTE MIGRATION 17 149 3.5e-05 0.0009637
170 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 25 278 3.754e-05 0.001021
171 REGULATION OF CELLULAR PROTEIN LOCALIZATION 40 552 3.733e-05 0.001021
172 POSITIVE REGULATION OF CELL CYCLE 28 332 4.187e-05 0.001133
173 REGULATION OF GTPASE ACTIVITY 46 673 4.228e-05 0.001137
174 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 69 1152 4.322e-05 0.001156
175 POSITIVE REGULATION OF CELL CYCLE PROCESS 23 247 4.43e-05 0.001178
176 UROGENITAL SYSTEM DEVELOPMENT 26 299 4.68e-05 0.001237
177 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 21 216 5.031e-05 0.001323
178 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 30 372 5.193e-05 0.001357
179 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 58 926 5.368e-05 0.00138
180 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 17 154 5.341e-05 0.00138
181 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 49 740 5.325e-05 0.00138
182 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 97 1784 5.63e-05 0.001439
183 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 84 1492 5.729e-05 0.001457
184 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 13 98 6.065e-05 0.001525
185 REGULATION OF MITOTIC CELL CYCLE 35 468 6.037e-05 0.001525
186 EXTRACELLULAR STRUCTURE ORGANIZATION 26 304 6.176e-05 0.001545
187 NEGATIVE REGULATION OF CELL CYCLE 33 433 6.78e-05 0.001687
188 OVULATION CYCLE 14 113 6.866e-05 0.001699
189 CHROMOSOME LOCALIZATION 10 61 6.988e-05 0.00172
190 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 29 360 7.025e-05 0.00172
191 STRIATED MUSCLE CELL DIFFERENTIATION 18 173 7.118e-05 0.001734
192 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 20 205 7.184e-05 0.001741
193 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 12 87 7.865e-05 0.00183
194 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 12 87 7.865e-05 0.00183
195 VIRAL ENTRY INTO HOST CELL 12 87 7.865e-05 0.00183
196 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 12 87 7.865e-05 0.00183
197 MOVEMENT IN HOST ENVIRONMENT 12 87 7.865e-05 0.00183
198 ENTRY INTO HOST 12 87 7.865e-05 0.00183
199 REGULATION OF PHOSPHORUS METABOLIC PROCESS 89 1618 7.823e-05 0.00183
200 ENTRY INTO HOST CELL 12 87 7.865e-05 0.00183
201 TUBE FORMATION 15 129 8.006e-05 0.001853
202 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 37 514 8.308e-05 0.001914
203 MUSCLE TISSUE DEVELOPMENT 24 275 8.552e-05 0.001951
204 REGULATION OF ORGANELLE ORGANIZATION 69 1178 8.547e-05 0.001951
205 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 11 75 8.801e-05 0.001984
206 ANGIOGENESIS 25 293 8.825e-05 0.001984
207 NEURAL CREST CELL DIFFERENTIATION 11 75 8.801e-05 0.001984
208 RESPONSE TO STEROID HORMONE 36 497 9.115e-05 0.002039
209 FEMALE SEX DIFFERENTIATION 14 116 9.159e-05 0.002039
210 REGULATION OF DNA REPLICATION 17 161 9.338e-05 0.002069
211 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 15 131 9.552e-05 0.002106
212 OUTFLOW TRACT SEPTUM MORPHOGENESIS 5 14 0.0001004 0.002203
213 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 25 296 0.0001038 0.002267
214 SKIN DEVELOPMENT 20 211 0.0001071 0.002329
215 POSITIVE REGULATION OF KINASE ACTIVITY 35 482 0.0001083 0.002344
216 NEGATIVE REGULATION OF MOLECULAR FUNCTION 64 1079 0.000109 0.002348
217 DEVELOPMENTAL GROWTH 27 333 0.0001109 0.002377
218 CELL CYCLE PROCESS 64 1081 0.0001149 0.002452
219 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 9 53 0.000121 0.002571
220 REGULATION OF NIK NF KAPPAB SIGNALING 8 42 0.0001248 0.002639
221 INTRACELLULAR SIGNAL TRANSDUCTION 86 1572 0.0001254 0.00264
222 REGULATION OF PROTEIN MODIFICATION PROCESS 92 1710 0.0001297 0.002719
223 SALIVARY GLAND DEVELOPMENT 7 32 0.0001326 0.002754
224 EMBRYONIC FORELIMB MORPHOGENESIS 7 32 0.0001326 0.002754
225 PROSTATE GLAND MORPHOGENESIS 6 23 0.0001425 0.002934
226 RESPONSE TO BACTERIUM 37 528 0.0001431 0.002934
227 NEGATIVE REGULATION OF MULTI ORGANISM PROCESS 16 151 0.0001427 0.002934
228 MORPHOGENESIS OF AN EPITHELIAL FOLD 5 15 0.000146 0.00298
229 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 8 43 0.0001484 0.003015
230 CELLULAR RESPONSE TO OXIDATIVE STRESS 18 184 0.000157 0.003176
231 CELLULAR COMPONENT MORPHOGENESIS 55 900 0.0001581 0.003185
232 CELLULAR RESPONSE TO MECHANICAL STIMULUS 11 80 0.0001594 0.003198
233 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 9 55 0.0001626 0.003247
234 CYTOSKELETON ORGANIZATION 52 838 0.0001645 0.003271
235 POSITIVE REGULATION OF DNA METABOLIC PROCESS 18 185 0.0001681 0.0033
236 CELL JUNCTION ORGANIZATION 18 185 0.0001681 0.0033
237 RESPONSE TO ESTROGEN 20 218 0.000167 0.0033
238 PLACENTA DEVELOPMENT 15 138 0.000172 0.003362
239 REGULATION OF CELL JUNCTION ASSEMBLY 10 68 0.0001788 0.003467
240 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 11 81 0.0001785 0.003467
241 POSITIVE REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 6 24 0.0001842 0.003553
242 RESPONSE TO ALCOHOL 28 362 0.0001848 0.003553
243 MUSCLE CELL DIFFERENTIATION 21 237 0.0001883 0.003606
244 EYE DEVELOPMENT 26 326 0.0001919 0.003659
245 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 41 616 0.0001928 0.003661
246 RESPONSE TO INORGANIC SUBSTANCE 34 479 0.0002075 0.003877
247 SPROUTING ANGIOGENESIS 8 45 0.0002068 0.003877
248 EXOCRINE SYSTEM DEVELOPMENT 8 45 0.0002068 0.003877
249 REGULATION OF LEUKOCYTE CHEMOTAXIS 12 96 0.0002051 0.003877
250 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 13 111 0.000219 0.004077
251 HAIR CYCLE 11 83 0.0002223 0.004105
252 MOLTING CYCLE 11 83 0.0002223 0.004105
253 IN UTERO EMBRYONIC DEVELOPMENT 25 311 0.0002243 0.004126
254 NEGATIVE REGULATION OF CELL ADHESION 20 223 0.0002262 0.004143
255 MUSCLE ORGAN MORPHOGENESIS 10 70 0.0002284 0.004168
256 LUNG CELL DIFFERENTIATION 6 25 0.0002348 0.004266
257 REGULATION OF ACTIN FILAMENT BASED PROCESS 25 312 0.0002356 0.004266
258 IMMUNE SYSTEM DEVELOPMENT 39 582 0.0002395 0.004319
259 ACTIN FILAMENT ORGANIZATION 17 174 0.0002404 0.004319
260 O GLYCAN PROCESSING 9 58 0.0002469 0.004412
261 POSITIVE REGULATION OF OSSIFICATION 11 84 0.0002475 0.004412
262 RESPONSE TO REACTIVE OXYGEN SPECIES 18 191 0.0002502 0.004443
263 RESPONSE TO METAL ION 26 333 0.0002678 0.004737
264 RESPONSE TO INTERFERON GAMMA 15 144 0.0002751 0.004848
265 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 5 17 0.0002831 0.00497
266 CELL FATE COMMITMENT 20 227 0.000286 0.004984
267 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 59 1008 0.0002859 0.004984
268 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 7 36 0.0002894 0.005006
269 HEAD MORPHOGENESIS 7 36 0.0002894 0.005006
270 REGULATION OF NECROTIC CELL DEATH 6 26 0.0002959 0.005099
271 REGENERATION 16 161 0.0002991 0.005136
272 CONNECTIVE TISSUE DEVELOPMENT 18 194 0.000303 0.005184
273 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 19 211 0.0003055 0.005207
274 REGULATION OF MULTI ORGANISM PROCESS 33 470 0.0003112 0.005285
275 REGULATION OF OSSIFICATION 17 178 0.0003147 0.005324
276 REGULATION OF CELLULAR LOCALIZATION 71 1277 0.0003172 0.005347
277 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 20 229 0.0003208 0.005355
278 RESPONSE TO ESTRADIOL 15 146 0.0003196 0.005355
279 CHONDROCYTE DIFFERENTIATION 9 60 0.0003211 0.005355
280 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 8 48 0.0003285 0.005459
281 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 49 799 0.000331 0.005481
282 REGULATION OF PROTEIN LOCALIZATION 56 950 0.0003423 0.005648
283 REGULATION OF NUCLEAR DIVISION 16 163 0.0003439 0.005655
284 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 7 37 0.0003457 0.005664
285 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 14 132 0.0003615 0.005901
286 DIGESTIVE SYSTEM PROCESS 9 61 0.0003646 0.005931
287 POSITIVE REGULATION OF NEUTROPHIL MIGRATION 6 27 0.0003687 0.00594
288 MAMMARY GLAND DEVELOPMENT 13 117 0.0003693 0.00594
289 REGULATION OF DNA METABOLIC PROCESS 26 340 0.0003691 0.00594
290 RESPONSE TO TRANSITION METAL NANOPARTICLE 15 148 0.0003702 0.00594
291 REGULATION OF STEM CELL PROLIFERATION 11 88 0.0003735 0.005972
292 REGULATION OF LEUKOCYTE DIFFERENTIATION 20 232 0.0003799 0.006054
293 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 20 233 0.0004017 0.006335
294 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 13 118 0.0004013 0.006335
295 REGULATION OF VASCULATURE DEVELOPMENT 20 233 0.0004017 0.006335
296 REGULATION OF VIRAL GENOME REPLICATION 10 75 0.0004048 0.006364
297 CARDIAC VENTRICLE MORPHOGENESIS 9 62 0.0004128 0.006423
298 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 18 199 0.0004127 0.006423
299 MESENCHYME MORPHOGENESIS 7 38 0.0004105 0.006423
300 NEGATIVE REGULATION OF GENE EXPRESSION 80 1493 0.0004146 0.006431
301 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 14 134 0.0004218 0.00652
302 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 19 217 0.0004344 0.006693
303 FACE DEVELOPMENT 8 50 0.0004382 0.006729
304 REGULATION OF KERATINOCYTE PROLIFERATION 6 28 0.0004548 0.006961
305 REGULATION OF ATTACHMENT OF SPINDLE MICROTUBULES TO KINETOCHORE 4 11 0.0004855 0.007335
306 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 27 365 0.0004825 0.007335
307 PROSTATE GLANDULAR ACINUS DEVELOPMENT 4 11 0.0004855 0.007335
308 CYTOSKELETON DEPENDENT CYTOKINESIS 7 39 0.0004846 0.007335
309 REGULATION OF BONE DEVELOPMENT 5 19 0.0005004 0.007535
310 NEURAL CREST CELL MIGRATION 8 51 0.0005032 0.007553
311 PROTEIN COMPLEX SUBUNIT ORGANIZATION 81 1527 0.0005176 0.007743
312 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 29 406 0.0005358 0.00799
313 EPIDERMIS MORPHOGENESIS 6 29 0.0005557 0.008235
314 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 6 29 0.0005557 0.008235
315 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 59 1036 0.0005692 0.00835
316 REGULATION OF KINASE ACTIVITY 47 776 0.0005707 0.00835
317 FORELIMB MORPHOGENESIS 7 40 0.000569 0.00835
318 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 59 1036 0.0005692 0.00835
319 POSITIVE REGULATION OF CYTOKINE PRODUCTION 27 370 0.0005945 0.008672
320 MULTICELLULAR ORGANISM METABOLIC PROCESS 11 93 0.0006029 0.008767
321 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 10 79 0.0006169 0.008942
322 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 5 20 0.0006472 0.009352
323 MESODERM MORPHOGENESIS 9 66 0.0006611 0.009523
324 RESPONSE TO HYDROGEN PEROXIDE 12 109 0.0006671 0.009581
325 ACTIVATION OF PROTEIN KINASE ACTIVITY 22 279 0.0006762 0.009681
NumGOOverlapSizeP ValueAdj. P Value
1 ACTIN BINDING 34 393 3.752e-06 0.0008714
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 30 315 2.039e-06 0.0008714
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 47 629 3.499e-06 0.0008714
4 MACROMOLECULAR COMPLEX BINDING 86 1399 1.657e-06 0.0008714
5 CHEMOKINE RECEPTOR BINDING 11 57 6.041e-06 0.001122
6 CHEMOKINE ACTIVITY 10 48 7.795e-06 0.001126
7 CYTOKINE RECEPTOR BINDING 26 271 8.481e-06 0.001126
8 RECEPTOR BINDING 84 1476 3.932e-05 0.004566
9 PROTEIN DOMAIN SPECIFIC BINDING 43 624 6.221e-05 0.006422
10 PROTEIN KINASE C BINDING 9 50 7.547e-05 0.007011
11 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 27 328 8.611e-05 0.007273
12 SEQUENCE SPECIFIC DNA BINDING 62 1037 0.0001122 0.008685
13 PROTEIN COMPLEX BINDING 57 935 0.0001282 0.009162
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE MICRODOMAIN 33 288 7.777e-09 4.542e-06
2 MEMBRANE REGION 79 1134 3.11e-08 9.082e-06
3 CONDENSED CHROMOSOME OUTER KINETOCHORE 7 12 5.933e-08 1.155e-05
4 CELL SURFACE 58 757 1.061e-07 1.549e-05
5 ANCHORING JUNCTION 42 489 3.332e-07 3.891e-05
6 CELL SUBSTRATE JUNCTION 36 398 6.864e-07 6.681e-05
7 EXTRACELLULAR SPACE 83 1376 5.295e-06 0.0004418
8 CONDENSED CHROMOSOME 21 195 1.08e-05 0.0007888
9 TRANSCRIPTION FACTOR COMPLEX 27 298 1.626e-05 0.001055
10 INTRINSIC COMPONENT OF PLASMA MEMBRANE 93 1649 2.071e-05 0.00121
11 CHROMOSOME CENTROMERIC REGION 19 174 2.309e-05 0.001226
12 APICAL PART OF CELL 30 361 2.975e-05 0.001403
13 PLASMA MEMBRANE REGION 59 929 3.123e-05 0.001403
14 ACTIN CYTOSKELETON 34 444 4.806e-05 0.002005
15 MIDBODY 15 132 0.0001042 0.004056
16 EXTRACELLULAR MATRIX 32 426 0.0001138 0.004155
17 CELL JUNCTION 67 1151 0.0001301 0.004294
18 KINETOCHORE 14 120 0.0001323 0.004294
19 PHAGOCYTIC VESICLE MEMBRANE 9 58 0.0002469 0.007589

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 TNF_signaling_pathway_hsa04668 18 108 7.631e-08 3.968e-06
2 p53_signaling_pathway_hsa04115 13 68 9.738e-07 2.532e-05
3 Cytokine_cytokine_receptor_interaction_hsa04060 27 270 2.622e-06 4.545e-05
4 Apoptosis_hsa04210 17 138 1.278e-05 0.0001662
5 MAPK_signaling_pathway_hsa04010 24 295 0.0002489 0.002505
6 Adherens_junction_hsa04520 10 72 0.000289 0.002505
7 Necroptosis_hsa04217 15 164 0.001084 0.007434
8 Apoptosis_multiple_species_hsa04215 6 33 0.001144 0.007434
9 Ferroptosis_hsa04216 6 40 0.003189 0.01842
10 Tight_junction_hsa04530 14 170 0.004123 0.02144
11 Hippo_signaling_pathway_hsa04390 13 154 0.004545 0.02149
12 Cellular_senescence_hsa04218 13 160 0.006249 0.02708
13 Focal_adhesion_hsa04510 15 199 0.006885 0.02754
14 NF_kappa_B_signaling_pathway_hsa04064 9 95 0.008214 0.03051
15 Regulation_of_actin_cytoskeleton_hsa04810 15 208 0.01014 0.03396
16 ECM_receptor_interaction_hsa04512 8 82 0.01045 0.03396
17 Phagosome_hsa04145 11 152 0.02483 0.07185
18 Ras_signaling_pathway_hsa04014 15 232 0.02487 0.07185
19 Endocytosis_hsa04144 15 244 0.03651 0.09529
20 PI3K_Akt_signaling_pathway_hsa04151 20 352 0.03665 0.09529
21 Rap1_signaling_pathway_hsa04015 13 206 0.04133 0.09839
22 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.04163 0.09839
23 FoxO_signaling_pathway_hsa04068 9 132 0.0547 0.1237
24 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.08917 0.1869
25 Wnt_signaling_pathway_hsa04310 9 146 0.08987 0.1869
26 Lysosome_hsa04142 7 123 0.1673 0.3315
27 Cell_cycle_hsa04110 7 124 0.1721 0.3315
28 TGF_beta_signaling_pathway_hsa04350 5 84 0.1962 0.3644
29 Gap_junction_hsa04540 5 88 0.2225 0.399
30 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.2508 0.4347
31 Phospholipase_D_signaling_pathway_hsa04072 7 146 0.2907 0.4876
32 HIF_1_signaling_pathway_hsa04066 5 100 0.3066 0.4982
33 VEGF_signaling_pathway_hsa04370 3 59 0.3696 0.5735
34 ErbB_signaling_pathway_hsa04012 4 85 0.381 0.5735
35 Jak_STAT_signaling_pathway_hsa04630 7 162 0.386 0.5735
36 cAMP_signaling_pathway_hsa04024 8 198 0.4433 0.6404
37 ABC_transporters_hsa02010 2 45 0.4964 0.6916
38 Calcium_signaling_pathway_hsa04020 7 182 0.5054 0.6916
39 Notch_signaling_pathway_hsa04330 2 48 0.531 0.7079
40 Peroxisome_hsa04146 3 83 0.5928 0.7706
41 Sphingolipid_signaling_pathway_hsa04071 4 118 0.6345 0.8048
42 Oocyte_meiosis_hsa04114 4 124 0.6729 0.8235
43 Mitophagy_animal_hsa04137 2 65 0.6953 0.8235
44 Autophagy_animal_hsa04140 4 128 0.6968 0.8235
45 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.7197 0.8317
46 mTOR_signaling_pathway_hsa04150 4 151 0.8101 0.8973
47 AMPK_signaling_pathway_hsa04152 3 121 0.8265 0.8973
48 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.8833 0.9247
49 Neuroactive_ligand_receptor_interaction_hsa04080 7 278 0.8891 0.9247
50 Apelin_signaling_pathway_hsa04371 2 137 0.9636 0.9825

Quest ID: 6ea3e1f55a9e95961581421d3501770d