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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p CSNK2A1 0.06 0.9566 -0.12 0.846 miRNAWalker2 validate; TargetScan -0.56 0.03878
2 hsa-let-7b-5p CSNK2A1 0.02 0.98368 -0.12 0.846 miRNAWalker2 validate -0.22 0.0039
3 hsa-let-7b-5p MYC 0.02 0.98368 0.33 0.7029 miRNAWalker2 validate -0.52 0.0321
4 hsa-let-7b-5p NFATC3 0.02 0.98368 0.01 0.98354 miRNAWalker2 validate -0.14 0.04252
5 hsa-let-7c-5p CSNK2A1 0.17 0.86763 -0.12 0.846 miRNAWalker2 validate -0.33 0.0001
6 hsa-let-7c-5p MYC 0.17 0.86763 0.33 0.7029 miRNAWalker2 validate; miRTarBase -0.6 0.02772
7 hsa-miR-101-3p FZD6 0.46 0.57468 -0.07 0.91012 miRNAWalker2 validate; MirTarget -0.52 0.00135
8 hsa-miR-101-3p RAC1 0.46 0.57468 -0.04 0.96396 miRNAWalker2 validate; MirTarget -0.13 0.01201
9 hsa-miR-146a-5p SMAD4 0.04 0.96588 0.06 0.92599 miRNAWalker2 validate; miRTarBase -0.09 0.00918
10 hsa-miR-155-5p PSEN1 0.17 0.84173 0.05 0.93618 miRNAWalker2 validate -0.09 0.01427
11 hsa-miR-155-5p SMAD3 0.17 0.84173 0.07 0.90068 miRNAWalker2 validate -0.14 0.00016
12 hsa-miR-17-5p SMAD3 -0.08 0.938 0.07 0.90068 miRNAWalker2 validate -0.23 0.03985
13 hsa-miR-186-5p CAMK2B -0.11 0.84518 0.1 0.82629 miRNAWalker2 validate; miRNATAP -0.1 0.00826
14 hsa-miR-18a-5p SMAD3 -0.28 0.69983 0.07 0.90068 miRNAWalker2 validate -0.09 0.04443
15 hsa-miR-192-5p FZD7 0.32 0.76716 -0.24 0.59052 miRNAWalker2 validate -0.86 0
16 hsa-miR-192-5p VANGL1 0.32 0.76716 -0.27 0.60104 miRNAWalker2 validate -0.21 0.01087
17 hsa-miR-193b-3p LEF1 0.05 0.94279 -0.1 0.84018 miRNAWalker2 validate -0.16 0.02205
18 hsa-miR-193b-3p RAC2 0.05 0.94279 -0.02 0.98013 miRNAWalker2 validate -0.23 0.01976
19 hsa-miR-215-5p FZD7 0.29 0.77767 -0.24 0.59052 miRNAWalker2 validate -0.9 0
20 hsa-miR-22-3p CSNK2A1 0.1 0.91786 -0.12 0.846 miRNAWalker2 validate -0.17 0.00774
21 hsa-miR-221-3p LRP6 -0.14 0.84636 0.01 0.99054 miRNAWalker2 validate -0.09 0.0368
22 hsa-miR-26b-5p RUVBL1 0.18 0.86138 -0.11 0.86633 miRNAWalker2 validate -0.5 0.00545
23 hsa-miR-30c-5p PLCB1 0.04 0.96573 -0.25 0.67858 miRNAWalker2 validate -0.55 0.01258
24 hsa-miR-375 PRKCA -0.32 0.61805 -0.09 0.86855 miRNAWalker2 validate -0.13 1.0E-5 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A
25 hsa-miR-7-5p LRP6 -0.32 0.50639 0.01 0.99054 miRNAWalker2 validate; miRNATAP -0.11 0.03816
26 hsa-miR-9-5p CCND1 -0.49 0.34593 -0.22 0.7533 miRNAWalker2 validate -0.31 0.00224
27 hsa-miR-92a-3p CCND1 -0.1 0.92119 -0.22 0.7533 miRNAWalker2 validate -0.49 0.01601
28 hsa-miR-92a-3p PRKCA -0.1 0.92119 -0.09 0.86855 miRNAWalker2 validate -0.18 0.01354
29 hsa-miR-92a-3p TBL1X -0.1 0.92119 -0.11 0.85643 miRNAWalker2 validate; mirMAP -0.2 0.04743
30 hsa-miR-92a-3p WNT5A -0.1 0.92119 0.25 0.64477 miRNAWalker2 validate -0.53 0.04554
31 hsa-miR-98-5p FZD10 0.11 0.8847 0.16 0.66548 miRNAWalker2 validate -0.19 0.03987
32 hsa-miR-135b-5p APC -0.49 0.29516 0.05 0.90894 miRTarBase; MirTarget -0.13 0.01049
33 hsa-miR-203a-3p SMAD4 0.05 0.9305 0.06 0.92599 miRTarBase -0.06 0.04217
34 hsa-miR-1-3p NFATC3 0.01 0.98198 0.01 0.98354 MirTarget -0.06 0.04706
35 hsa-miR-106b-5p CHP2 -0.05 0.95955 0.02 0.97004 MirTarget -0.15 0.01983
36 hsa-miR-125b-5p CSNK2A1 0.17 0.85694 -0.12 0.846 MirTarget; miRNATAP -0.21 0.00105
37 hsa-miR-126-5p MAP3K7 0.14 0.88257 -0.18 0.78319 MirTarget -0.21 0.03713
38 hsa-miR-130b-3p FOSL1 -0.04 0.95919 0.15 0.72462 MirTarget -0.17 0.03462
39 hsa-miR-138-5p CTNNBIP1 -0.02 0.95842 -0.01 0.98638 MirTarget -1.47 0.04263
40 hsa-miR-144-3p FZD6 0.68 0.41199 -0.07 0.91012 MirTarget -0.27 0.00335
41 hsa-miR-145-5p CTNNBIP1 -0.14 0.86568 -0.01 0.98638 MirTarget; miRNATAP -0.09 0.01956
42 hsa-miR-146a-5p WNT3 0.04 0.96588 0.04 0.94284 MirTarget -0.08 0.02555
43 hsa-miR-146b-5p WNT3 0.16 0.86149 0.04 0.94284 MirTarget; PITA; miRanda; miRNATAP -0.1 0.01375
44 hsa-miR-148a-3p PRKX 0.3 0.73989 -0.31 0.47618 MirTarget -0.17 0.03343
45 hsa-miR-149-5p BTRC 0.02 0.9553 -0.05 0.92234 MirTarget -0.22 0.00423
46 hsa-miR-152-3p SMAD2 0.04 0.95578 -0.04 0.94184 MirTarget -0.16 0.00639
47 hsa-miR-15a-5p WNT7A 0.05 0.95867 0.09 0.84991 MirTarget -0.11 0.019
48 hsa-miR-181c-5p TBL1X -0.05 0.90521 -0.11 0.85643 MirTarget; miRNATAP -0.22 0.0436
49 hsa-miR-181c-5p WNT16 -0.05 0.90521 0.01 0.98328 MirTarget -0.08 0.0003
50 hsa-miR-194-5p PPP3CA 0.3 0.77292 0.03 0.96917 MirTarget -0.26 0.00132
51 hsa-miR-195-5p BTRC 0.13 0.89885 -0.05 0.92234 MirTarget; miRNATAP -0.07 0.02256 23544130 Among the candidates we successfully identified CCNE1 CDC25A CCND3 CDK4 and BTRC as direct targets for miR-497 and miR-195
52 hsa-miR-195-5p WNT7A 0.13 0.89885 0.09 0.84991 MirTarget -0.14 0.02237
53 hsa-miR-200a-3p PRKACB -0.17 0.80009 0.05 0.93959 MirTarget; miRNATAP -0.13 0.00345
54 hsa-miR-200b-3p PRKACB -0.28 0.76928 0.05 0.93959 MirTarget; TargetScan -0.09 0.04184
55 hsa-miR-203a-3p NLK 0.05 0.9305 0.07 0.90192 MirTarget -0.08 0.01436
56 hsa-miR-204-5p TCF7L1 -0.1 0.83865 -0.04 0.95156 MirTarget; miRNATAP -0.14 0.01003
57 hsa-miR-204-5p CCND2 -0.1 0.83865 0.06 0.89294 MirTarget -0.09 0.00856
58 hsa-miR-20a-5p CHP2 0.01 0.99586 0.02 0.97004 MirTarget -0.15 0.04132
59 hsa-miR-20b-5p CHP2 -0.08 0.93718 0.02 0.97004 MirTarget -0.19 0.00797
60 hsa-miR-218-5p NFATC3 0.05 0.92577 0.01 0.98354 MirTarget; miRNATAP -0.08 0.02617
61 hsa-miR-222-3p SKP1 -0.29 0.7176 0.13 0.86156 MirTarget -0.09 0.00971
62 hsa-miR-23a-3p CTNNBIP1 -0.08 0.93245 -0.01 0.98638 MirTarget; miRNATAP -0.22 0.03546
63 hsa-miR-24-3p WNT8B -0.02 0.97761 0.09 0.86382 MirTarget -0.16 0.03775
64 hsa-miR-25-3p CAMK2A -0.06 0.94949 0.01 0.98729 MirTarget -0.13 0.04434
65 hsa-miR-27b-3p PRKCB 0.07 0.94023 -0.03 0.956 MirTarget; miRNATAP -0.32 0.0137
66 hsa-miR-30b-5p FZD3 0.03 0.97738 -0.25 0.53854 MirTarget -0.5 0.0027
67 hsa-miR-30c-5p FZD3 0.04 0.96573 -0.25 0.53854 MirTarget; miRNATAP -0.39 0.02224
68 hsa-miR-30d-5p FZD3 -0.04 0.96621 -0.25 0.53854 MirTarget; miRNATAP -0.27 0.0064
69 hsa-miR-331-3p TCF7 -0.14 0.76755 -0.01 0.98405 MirTarget; miRNATAP -0.36 0.00178
70 hsa-miR-363-3p CAMK2A -0.29 0.60696 0.01 0.98729 MirTarget -0.06 0.02306
71 hsa-miR-424-5p WNT7A 0.04 0.95947 0.09 0.84991 MirTarget -0.08 0.02314
72 hsa-miR-452-5p DAAM1 -0.17 0.80013 0.09 0.88405 MirTarget -0.15 0.03497
73 hsa-miR-484 NFATC4 -0.27 0.66007 0.07 0.886 MirTarget; miRNATAP -0.08 0.04414
74 hsa-miR-488-5p CTNNBIP1 -0 0.99968 -0.01 0.98638 MirTarget -3.71 0.01582
75 hsa-miR-491-5p BTRC 0.05 0.91381 -0.05 0.92234 MirTarget; miRanda -0.13 0.0011
76 hsa-miR-491-5p TCF7 0.05 0.91381 -0.01 0.98405 MirTarget; PITA; miRanda; miRNATAP -0.6 0.00014
77 hsa-miR-495-3p FZD4 -0.14 0.73114 0.18 0.75786 MirTarget -0.14 0.02314
78 hsa-miR-497-5p AXIN2 0.2 0.77847 -0.18 0.77056 MirTarget; miRNATAP -0.29 0.00666
79 hsa-miR-497-5p WNT7A 0.2 0.77847 0.09 0.84991 MirTarget -0.07 0.00615
80 hsa-miR-513a-5p CCND1 0.02 0.95422 -0.22 0.7533 MirTarget -0.62 0.01531
81 hsa-miR-520d-5p JUN -0.04 0.91848 -0.02 0.98096 MirTarget; PITA -0.41 0.03206
82 hsa-miR-522-3p JUN -0.09 0.85453 -0.02 0.98096 MirTarget; miRNATAP -0.14 0.04973
83 hsa-miR-93-5p CHP2 -0.18 0.84624 0.02 0.97004 MirTarget -0.23 0.00597
84 hsa-miR-516a-5p CREBBP -0.26 0.61714 -0.03 0.96068 PITA -0.05 0.01978
85 hsa-miR-520d-5p CREBBP -0.04 0.91848 -0.03 0.96068 PITA -0.16 0.02529
86 hsa-miR-142-3p ROCK2 0.24 0.77013 -0.07 0.92146 PITA; miRanda; miRNATAP -0.11 0.02512
87 hsa-miR-142-5p ROCK2 0.05 0.94703 -0.07 0.92146 PITA -0.13 0.01773
88 hsa-miR-142-5p SMAD3 0.05 0.94703 0.07 0.90068 PITA -0.16 0.0002 24558198 On TGF-β1 stimulation stable overexpression of miR-142-3p attenuated phosphorylation of SMAD3 an indispensable downstream effector in canonical TGF-β/Smad signaling via repression of TGFβR1 in A549 cells
89 hsa-miR-484 FZD4 -0.27 0.66007 0.18 0.75786 PITA -0.11 0.02514
90 hsa-miR-142-5p CAMK2A 0.05 0.94703 0.01 0.98729 PITA; miRNATAP -0.14 0
91 hsa-miR-520a-3p CCND1 0.04 0.91046 -0.22 0.7533 PITA; miRanda; miRNATAP -1.65 0.01645
92 hsa-miR-17-5p FZD4 -0.08 0.938 0.18 0.75786 TargetScan -0.26 0.00226
93 hsa-miR-199a-5p MAPK9 0.07 0.92651 -0.14 0.83424 miRanda -0.06 0.01035
94 hsa-miR-199a-5p WIF1 0.07 0.92651 -0.96 0.0787 miRanda -0.26 0.04138
95 hsa-miR-129-5p FZD6 0.01 0.97515 -0.07 0.91012 miRanda -8.74 0.01393
96 hsa-miR-139-5p PLCB1 0.44 0.40348 -0.25 0.67858 miRanda -0.19 0.01318
97 hsa-miR-139-5p MAPK9 0.44 0.40348 -0.14 0.83424 miRanda -0.11 0.03474
98 hsa-miR-139-5p VANGL1 0.44 0.40348 -0.27 0.60104 miRanda -0.13 0.02179
99 hsa-miR-139-5p RBX1 0.44 0.40348 -0.16 0.8479 miRanda -0.13 0.02066
100 hsa-miR-199b-5p WNT7B -0.2 0.67501 0.04 0.94078 miRanda; miRNATAP -0.09 0.02708
101 hsa-miR-142-3p TCF7 0.24 0.77013 -0.01 0.98405 miRanda -0.16 0.00404
102 hsa-miR-142-3p CER1 0.24 0.77013 -0.04 0.92414 miRanda -0.05 0.03172
103 hsa-miR-125a-5p TCF7 -0.41 0.61981 -0.01 0.98405 miRanda -0.14 0.02596
104 hsa-miR-193a-3p DVL2 0.09 0.88275 -0.23 0.69541 miRanda -0.14 0.00434
105 hsa-miR-206 DVL3 0.03 0.95871 -0.19 0.76387 miRanda -0.1 0.01048
106 hsa-miR-320a WNT8A -0.21 0.81669 -0.01 0.9876 miRanda -0.08 0.02643
107 hsa-miR-320a APC -0.21 0.81669 0.05 0.90894 miRanda -0.25 0.0026
108 hsa-miR-34c-5p RUVBL1 -0.02 0.95018 -0.11 0.86633 miRanda -1.46 0.0271
109 hsa-miR-375 CSNK2A2 -0.32 0.61805 -0.17 0.77854 miRanda -0.05 0.0498
110 hsa-miR-375 DAAM1 -0.32 0.61805 0.09 0.88405 miRanda -0.15 0.02606
111 hsa-miR-342-3p WIF1 -0.07 0.94152 -0.96 0.0787 miRanda -0.72 0.00899
112 hsa-miR-326 CREBBP -0.01 0.97755 -0.03 0.96068 miRanda -1.17 0.03379
113 hsa-miR-326 PRKACG -0.01 0.97755 0.04 0.92982 miRanda -1.35 0.00904
114 hsa-miR-338-3p PPP2R5D -0.11 0.79489 -0.07 0.90071 miRanda -0.21 0.02691
115 hsa-miR-338-3p PSEN1 -0.11 0.79489 0.05 0.93618 miRanda -0.24 0.03255
116 hsa-miR-429 NKD1 -0.15 0.80015 -0.19 0.74662 miRanda; miRNATAP -0.29 0.01293
117 hsa-miR-429 AXIN2 -0.15 0.80015 -0.18 0.77056 miRanda -0.29 0.0187
118 hsa-miR-429 FOSL1 -0.15 0.80015 0.15 0.72462 miRanda; miRNATAP -0.2 0.01407
119 hsa-miR-491-5p WNT1 0.05 0.91381 -0.01 0.97501 miRanda -0.15 0.00933
120 hsa-miR-491-5p FZD9 0.05 0.91381 0 0.99907 miRanda -0.19 0.00696
121 hsa-miR-491-5p PRKCG 0.05 0.91381 0.01 0.97908 miRanda -0.14 0.01829
122 hsa-miR-491-5p WNT10B 0.05 0.91381 0.05 0.92337 miRanda -0.23 0.01332
123 hsa-miR-520e NFATC4 -0.18 0.68212 0.07 0.886 miRanda -0.1 0.03924
124 hsa-miR-520d-3p WNT1 -0.09 0.83613 -0.01 0.97501 miRanda -0.12 0.00743
125 hsa-miR-520d-3p NFATC4 -0.09 0.83613 0.07 0.886 miRanda -0.13 0.01197
126 hsa-miR-543 PPP2R5E -0.28 0.48702 0.1 0.8769 miRanda; mirMAP -0.23 0.00283
127 hsa-miR-18a-5p CAMK2B -0.28 0.69983 0.1 0.82629 mirMAP -0.09 0.0002
128 hsa-miR-18b-5p CAMK2B -0.25 0.72989 0.1 0.82629 mirMAP -0.09 0.00036
129 hsa-miR-181b-5p LRP6 -0.15 0.82793 0.01 0.99054 mirMAP -0.1 0.03576
130 hsa-miR-618 LRP6 -0.05 0.88798 0.01 0.99054 mirMAP -0.7 0.01652
131 hsa-miR-181a-5p CSNK2A2 -0.01 0.9906 -0.17 0.77854 mirMAP -0.08 0.02287
132 hsa-miR-30b-5p CSNK2A2 0.03 0.97738 -0.17 0.77854 mirMAP -0.26 0.02617
133 hsa-miR-30c-5p CSNK2A2 0.04 0.96573 -0.17 0.77854 mirMAP -0.26 0.02856
134 hsa-miR-10a-5p CAMK2A -0.05 0.95447 0.01 0.98729 mirMAP -0.14 0.00036
135 hsa-miR-185-5p CAMK2A -0.09 0.89497 0.01 0.98729 mirMAP -0.09 0.04436
136 hsa-miR-27a-3p CAMK2A 0.03 0.97481 0.01 0.98729 mirMAP; miRNATAP -0.16 0.00673
137 hsa-miR-139-5p GSK3B 0.44 0.40348 -0.06 0.90829 mirMAP -0.08 0.0197
138 hsa-miR-26b-5p CSNK2A1 0.18 0.86138 -0.12 0.846 mirMAP -0.25 0.0452
139 hsa-miR-105-5p TBL1X 0.01 0.97896 -0.11 0.85643 mirMAP -1.54 0.02696
140 hsa-miR-130b-3p FZD3 -0.04 0.95919 -0.25 0.53854 mirMAP -0.13 0.00808
141 hsa-miR-145-5p FZD3 -0.14 0.86568 -0.25 0.53854 mirMAP -0.1 0.03199
142 hsa-miR-200b-3p FZD3 -0.28 0.76928 -0.25 0.53854 mirMAP -0.07 0.04935
143 hsa-miR-449a PPARD 0.01 0.97368 -0.16 0.78284 mirMAP -0.46 0.02266
144 hsa-miR-28-5p APC2 0.04 0.9618 0.06 0.90772 mirMAP -0.1 0.04201
145 hsa-miR-324-3p APC2 -0.1 0.82068 0.06 0.90772 mirMAP -0.13 0.01199
146 hsa-miR-485-5p NKD2 0.01 0.98078 -0.03 0.95625 mirMAP -0.4 0.02188
147 hsa-miR-182-5p DAAM2 -0.53 0.49455 0.21 0.68839 mirMAP -0.07 0.03615
148 hsa-miR-142-5p PRKCA 0.05 0.94703 -0.09 0.86855 mirMAP -0.19 0
149 hsa-miR-146a-5p PRKCA 0.04 0.96588 -0.09 0.86855 mirMAP -0.16 0.0001
150 hsa-miR-150-5p PRKCA 0.05 0.94712 -0.09 0.86855 mirMAP -0.12 1.0E-5

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 49 351 4.009e-67 1.865e-63
2 CANONICAL WNT SIGNALING PATHWAY 26 95 2.676e-42 6.226e-39
3 REGULATION OF WNT SIGNALING PATHWAY 29 310 9.399e-33 1.458e-29
4 NON CANONICAL WNT SIGNALING PATHWAY 22 140 7.149e-30 8.316e-27
5 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 21 197 8.232e-25 7.661e-22
6 POSITIVE REGULATION OF RESPONSE TO STIMULUS 42 1929 9.667e-23 7.496e-20
7 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 37 1492 1.551e-21 1.031e-18
8 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 38 1672 7.168e-21 4.169e-18
9 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 12 39 1.835e-20 9.488e-18
10 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 4.048e-20 1.883e-17
11 REGULATION OF PROTEIN MODIFICATION PROCESS 37 1710 1.594e-19 6.743e-17
12 POSITIVE REGULATION OF GENE EXPRESSION 37 1733 2.499e-19 9.69e-17
13 PATTERN SPECIFICATION PROCESS 22 418 3.088e-19 1.105e-16
14 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 30 1021 3.742e-19 1.244e-16
15 EPITHELIUM DEVELOPMENT 29 945 5.45e-19 1.691e-16
16 CELL PROLIFERATION 25 672 2.971e-18 8.64e-16
17 TISSUE DEVELOPMENT 34 1518 3.21e-18 8.786e-16
18 ORGAN MORPHOGENESIS 27 841 4.024e-18 1.04e-15
19 POSITIVE REGULATION OF CELL COMMUNICATION 34 1532 4.261e-18 1.044e-15
20 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 30 1135 7.081e-18 1.647e-15
21 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 32 1360 1.131e-17 2.506e-15
22 TUBE MORPHOGENESIS 19 323 1.508e-17 3.189e-15
23 REGULATION OF CELL DIFFERENTIATION 33 1492 1.81e-17 3.661e-15
24 NEGATIVE REGULATION OF CELL COMMUNICATION 30 1192 2.728e-17 5.288e-15
25 MORPHOGENESIS OF AN EPITHELIUM 20 400 4.479e-17 8.337e-15
26 TISSUE MORPHOGENESIS 22 533 5.352e-17 9.578e-15
27 EMBRYONIC MORPHOGENESIS 22 539 6.768e-17 1.166e-14
28 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 35 1805 7.691e-17 1.278e-14
29 TUBE DEVELOPMENT 22 552 1.115e-16 1.789e-14
30 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 35 1848 1.601e-16 2.404e-14
31 REGIONALIZATION 18 311 1.583e-16 2.404e-14
32 REGULATION OF PHOSPHORUS METABOLIC PROCESS 33 1618 2.008e-16 2.92e-14
33 EMBRYO DEVELOPMENT 26 894 2.15e-16 3.021e-14
34 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 31 1395 2.207e-16 3.021e-14
35 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 1036 7.361e-16 9.515e-14
36 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1036 7.361e-16 9.515e-14
37 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 28 1142 8.6e-16 1.082e-13
38 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 14 162 1.937e-15 2.371e-13
39 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 18 365 2.608e-15 3.111e-13
40 POSITIVE REGULATION OF MOLECULAR FUNCTION 33 1791 3.927e-15 4.569e-13
41 PROTEIN PHOSPHORYLATION 25 944 8.082e-15 9.172e-13
42 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 27 1152 9.911e-15 1.072e-12
43 CELL FATE COMMITMENT 15 227 9.742e-15 1.072e-12
44 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 25 957 1.104e-14 1.167e-12
45 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 8 22 1.132e-14 1.171e-12
46 RESPONSE TO OXYGEN CONTAINING COMPOUND 29 1381 1.26e-14 1.274e-12
47 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 12 110 1.328e-14 1.315e-12
48 NEURON DIFFERENTIATION 24 874 1.444e-14 1.4e-12
49 CARDIOVASCULAR SYSTEM DEVELOPMENT 23 788 1.609e-14 1.497e-12
50 CIRCULATORY SYSTEM DEVELOPMENT 23 788 1.609e-14 1.497e-12
51 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 1784 2.628e-14 2.398e-12
52 AXIS SPECIFICATION 11 90 4.959e-14 4.437e-12
53 REGULATION OF RESPONSE TO STRESS 29 1468 6.049e-14 5.311e-12
54 REGULATION OF CELL CYCLE 24 949 8.726e-14 7.519e-12
55 REGULATION OF CELL PROLIFERATION 29 1496 9.795e-14 8.287e-12
56 NEUROGENESIS 28 1402 1.467e-13 1.219e-11
57 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 337 1.979e-13 1.616e-11
58 INTRACELLULAR SIGNAL TRANSDUCTION 29 1572 3.442e-13 2.761e-11
59 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 3.975e-13 3.135e-11
60 CELL ACTIVATION 19 568 4.307e-13 3.34e-11
61 SENSORY ORGAN DEVELOPMENT 18 493 4.507e-13 3.438e-11
62 REGULATION OF CELL DEATH 28 1472 4.852e-13 3.641e-11
63 REGULATION OF ORGAN MORPHOGENESIS 14 242 5.096e-13 3.764e-11
64 ANTERIOR POSTERIOR PATTERN SPECIFICATION 13 194 5.705e-13 4.148e-11
65 REGULATION OF CELLULAR RESPONSE TO STRESS 20 691 1.353e-12 9.683e-11
66 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 15 323 1.674e-12 1.18e-10
67 REGULATION OF PROTEIN CATABOLIC PROCESS 16 393 2.067e-12 1.436e-10
68 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 21 801 2.204e-12 1.508e-10
69 PHOSPHORYLATION 25 1228 2.918e-12 1.968e-10
70 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 18 554 3.192e-12 2.122e-10
71 BETA CATENIN TCF COMPLEX ASSEMBLY 8 43 4.808e-12 3.151e-10
72 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 28 1656 8.376e-12 5.413e-10
73 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 12 197 1.466e-11 9.345e-10
74 RESPONSE TO ENDOGENOUS STIMULUS 26 1450 1.645e-11 1.034e-09
75 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 30 1977 1.725e-11 1.056e-09
76 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 11 152 1.704e-11 1.056e-09
77 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 20 799 1.884e-11 1.139e-09
78 REGULATION OF JNK CASCADE 11 159 2.782e-11 1.66e-09
79 REGULATION OF CELLULAR PROTEIN LOCALIZATION 17 552 3.236e-11 1.906e-09
80 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 11 162 3.408e-11 1.982e-09
81 POSITIVE REGULATION OF CATALYTIC ACTIVITY 26 1518 4.559e-11 2.619e-09
82 EMBRYONIC PATTERN SPECIFICATION 8 58 6.065e-11 3.442e-09
83 DORSAL VENTRAL PATTERN FORMATION 9 91 7.862e-11 4.408e-09
84 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 20 876 9.723e-11 5.386e-09
85 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 10 135 1.194e-10 6.539e-09
86 RESPONSE TO LIPID 20 888 1.237e-10 6.692e-09
87 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 21 1004 1.504e-10 8.042e-09
88 CELLULAR RESPONSE TO RETINOIC ACID 8 65 1.563e-10 8.263e-09
89 FC EPSILON RECEPTOR SIGNALING PATHWAY 10 142 1.971e-10 1.031e-08
90 HEART DEVELOPMENT 15 466 2.949e-10 1.525e-08
91 NEURAL TUBE DEVELOPMENT 10 149 3.17e-10 1.621e-08
92 REGULATION OF CELL MORPHOGENESIS 16 552 3.235e-10 1.636e-08
93 RESPONSE TO RETINOIC ACID 9 107 3.422e-10 1.712e-08
94 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 740 3.647e-10 1.805e-08
95 REGULATION OF PROTEIN LOCALIZATION 20 950 4.049e-10 1.983e-08
96 RESPONSE TO WOUNDING 16 563 4.312e-10 2.09e-08
97 CELL DEVELOPMENT 24 1426 4.585e-10 2.199e-08
98 GASTRULATION 10 155 4.674e-10 2.219e-08
99 REGULATION OF MAPK CASCADE 17 660 5.113e-10 2.379e-08
100 EMBRYONIC ORGAN DEVELOPMENT 14 406 5.079e-10 2.379e-08
101 REGULATION OF EMBRYONIC DEVELOPMENT 9 114 6.053e-10 2.788e-08
102 NEGATIVE REGULATION OF CELL DEATH 19 872 6.86e-10 3.129e-08
103 EMBRYONIC ORGAN MORPHOGENESIS 12 279 8.216e-10 3.712e-08
104 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 9.099e-10 4.071e-08
105 REGULATION OF BINDING 12 283 9.661e-10 4.281e-08
106 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 228 1.321e-09 5.799e-08
107 POSITIVE REGULATION OF CELL PROLIFERATION 18 814 1.663e-09 7.233e-08
108 RHYTHMIC PROCESS 12 298 1.735e-09 7.476e-08
109 REGULATION OF IMMUNE SYSTEM PROCESS 23 1403 1.955e-09 8.347e-08
110 SEGMENTATION 8 89 2.029e-09 8.582e-08
111 EPITHELIAL TO MESENCHYMAL TRANSITION 7 56 2.074e-09 8.692e-08
112 REGULATION OF CATABOLIC PROCESS 17 731 2.402e-09 9.979e-08
113 REGULATION OF PROTEIN TARGETING 12 307 2.428e-09 9.999e-08
114 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 9 134 2.559e-09 1.027e-07
115 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 13 381 2.557e-09 1.027e-07
116 REGULATION OF CELL DEVELOPMENT 18 836 2.532e-09 1.027e-07
117 REGULATION OF TRANSFERASE ACTIVITY 19 946 2.64e-09 1.05e-07
118 EMBRYONIC AXIS SPECIFICATION 6 33 2.946e-09 1.162e-07
119 POSITIVE REGULATION OF MAPK CASCADE 14 470 3.35e-09 1.299e-07
120 WOUND HEALING 14 470 3.35e-09 1.299e-07
121 POSITIVE REGULATION OF CELL DEVELOPMENT 14 472 3.536e-09 1.36e-07
122 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 34 3.567e-09 1.36e-07
123 REGULATION OF IMMUNE RESPONSE 18 858 3.807e-09 1.439e-07
124 RESPONSE TO GROWTH FACTOR 14 475 3.834e-09 1.439e-07
125 SOMITOGENESIS 7 62 4.316e-09 1.606e-07
126 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 13 406 5.482e-09 2.025e-07
127 REGULATION OF KINASE ACTIVITY 17 776 5.866e-09 2.149e-07
128 FC RECEPTOR SIGNALING PATHWAY 10 206 7.39e-09 2.685e-07
129 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 19 1008 7.443e-09 2.685e-07
130 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 23 1517 8.674e-09 3.105e-07
131 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 11 274 9.019e-09 3.203e-07
132 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 8 109 1.025e-08 3.587e-07
133 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 513 1.018e-08 3.587e-07
134 RESPONSE TO ORGANIC CYCLIC COMPOUND 18 917 1.071e-08 3.721e-07
135 REGULATION OF CELLULAR LOCALIZATION 21 1277 1.126e-08 3.852e-07
136 NEGATIVE REGULATION OF CELL DIFFERENTIATION 15 609 1.121e-08 3.852e-07
137 DORSAL VENTRAL AXIS SPECIFICATION 5 20 1.173e-08 3.984e-07
138 REGULATION OF PROTEOLYSIS 16 711 1.213e-08 4.089e-07
139 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 15 616 1.305e-08 4.368e-07
140 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 10 220 1.385e-08 4.604e-07
141 CELLULAR RESPONSE TO LIPID 13 457 2.232e-08 7.263e-07
142 UROGENITAL SYSTEM DEVELOPMENT 11 299 2.219e-08 7.263e-07
143 SOMITE DEVELOPMENT 7 78 2.206e-08 7.263e-07
144 SINGLE ORGANISM CELL ADHESION 13 459 2.35e-08 7.593e-07
145 KIDNEY EPITHELIUM DEVELOPMENT 8 125 3.02e-08 9.688e-07
146 SENSORY ORGAN MORPHOGENESIS 10 239 3.04e-08 9.688e-07
147 ANTERIOR POSTERIOR AXIS SPECIFICATION 6 48 3.117e-08 9.799e-07
148 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 470 3.103e-08 9.799e-07
149 NEGATIVE REGULATION OF GENE EXPRESSION 22 1493 3.35e-08 1.046e-06
150 REGULATION OF CELLULAR COMPONENT BIOGENESIS 16 767 3.492e-08 1.083e-06
151 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 9 181 3.557e-08 1.096e-06
152 REGULATION OF CELLULAR COMPONENT MOVEMENT 16 771 3.753e-08 1.149e-06
153 REGULATION OF PROTEIN IMPORT 9 183 3.912e-08 1.19e-06
154 PALATE DEVELOPMENT 7 85 4.032e-08 1.218e-06
155 REGULATION OF CYTOPLASMIC TRANSPORT 13 481 4.069e-08 1.221e-06
156 POSITIVE REGULATION OF KINASE ACTIVITY 13 482 4.169e-08 1.243e-06
157 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 8 131 4.359e-08 1.292e-06
158 MESENCHYME DEVELOPMENT 9 190 5.406e-08 1.572e-06
159 STEM CELL DIFFERENTIATION 9 190 5.406e-08 1.572e-06
160 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 190 5.406e-08 1.572e-06
161 EPITHELIAL CELL PROLIFERATION 7 89 5.559e-08 1.607e-06
162 REPRODUCTIVE SYSTEM DEVELOPMENT 12 408 5.702e-08 1.638e-06
163 MESONEPHROS DEVELOPMENT 7 90 6.01e-08 1.715e-06
164 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 258 6.246e-08 1.772e-06
165 POSITIVE REGULATION OF CELL CYCLE 11 332 6.456e-08 1.821e-06
166 BIOLOGICAL ADHESION 18 1032 6.518e-08 1.827e-06
167 DEVELOPMENTAL GROWTH 11 333 6.656e-08 1.854e-06
168 INNER EAR MORPHOGENESIS 7 92 7.003e-08 1.94e-06
169 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 10 263 7.476e-08 2.058e-06
170 POSITIVE REGULATION OF CELL DEATH 14 605 7.958e-08 2.178e-06
171 NEURAL TUBE FORMATION 7 94 8.131e-08 2.213e-06
172 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 13 514 8.806e-08 2.382e-06
173 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 8 144 9.104e-08 2.449e-06
174 STEM CELL PROLIFERATION 6 60 1.225e-07 3.277e-06
175 CELL CYCLE PROCESS 18 1081 1.308e-07 3.477e-06
176 HEART MORPHOGENESIS 9 212 1.381e-07 3.65e-06
177 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 10 282 1.432e-07 3.766e-06
178 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 11 360 1.461e-07 3.82e-06
179 REGULATION OF EPITHELIAL CELL PROLIFERATION 10 285 1.58e-07 4.108e-06
180 RESPONSE TO NITROGEN COMPOUND 16 859 1.65e-07 4.241e-06
181 POSITIVE REGULATION OF JUN KINASE ACTIVITY 6 63 1.648e-07 4.241e-06
182 NEGATIVE REGULATION OF CELL PROLIFERATION 14 643 1.678e-07 4.289e-06
183 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 9 218 1.75e-07 4.45e-06
184 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 289 1.798e-07 4.547e-06
185 NEGATIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 6 64 1.812e-07 4.558e-06
186 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 983 1.829e-07 4.576e-06
187 LOCOMOTION 18 1114 2.046e-07 5.091e-06
188 REGULATION OF TRANSPORT 23 1804 2.123e-07 5.254e-06
189 REGULATION OF CELL CYCLE PROCESS 13 558 2.265e-07 5.576e-06
190 CELL DEATH 17 1001 2.366e-07 5.793e-06
191 PROTEIN COMPLEX SUBUNIT ORGANIZATION 21 1527 2.4e-07 5.816e-06
192 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 67 2.39e-07 5.816e-06
193 REGULATION OF MITOTIC CELL CYCLE 12 468 2.511e-07 6.053e-06
194 VASCULATURE DEVELOPMENT 12 469 2.569e-07 6.161e-06
195 EAR MORPHOGENESIS 7 112 2.721e-07 6.493e-06
196 RESPONSE TO HORMONE 16 893 2.786e-07 6.613e-06
197 MORPHOGENESIS OF A BRANCHING STRUCTURE 8 167 2.851e-07 6.733e-06
198 REGULATION OF STEM CELL DIFFERENTIATION 7 113 2.892e-07 6.796e-06
199 NEURAL PRECURSOR CELL PROLIFERATION 6 70 3.111e-07 7.228e-06
200 APPENDAGE DEVELOPMENT 8 169 3.122e-07 7.228e-06
201 LIMB DEVELOPMENT 8 169 3.122e-07 7.228e-06
202 RESPONSE TO INORGANIC SUBSTANCE 12 479 3.218e-07 7.412e-06
203 RESPONSE TO ABIOTIC STIMULUS 17 1024 3.259e-07 7.47e-06
204 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 684 3.547e-07 8.091e-06
205 CELLULAR RESPONSE TO STRESS 21 1565 3.613e-07 8.16e-06
206 MESENCHYME MORPHOGENESIS 5 38 3.596e-07 8.16e-06
207 GLAND DEVELOPMENT 11 395 3.688e-07 8.291e-06
208 REGULATION OF CELL SUBSTRATE ADHESION 8 173 3.733e-07 8.35e-06
209 PARAXIAL MESODERM DEVELOPMENT 4 16 3.759e-07 8.369e-06
210 CELLULAR RESPONSE TO ACID CHEMICAL 8 175 4.075e-07 9.028e-06
211 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 119 4.117e-07 9.079e-06
212 RESPONSE TO ACID CHEMICAL 10 319 4.463e-07 9.796e-06
213 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 4.612e-07 1.003e-05
214 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 11 404 4.61e-07 1.003e-05
215 REGULATION OF ORGANELLE ORGANIZATION 18 1178 4.658e-07 1.008e-05
216 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 17 4.901e-07 1.056e-05
217 CELL CYCLE 19 1316 4.966e-07 1.065e-05
218 GROWTH 11 410 5.332e-07 1.138e-05
219 HEAD DEVELOPMENT 14 709 5.458e-07 1.154e-05
220 EYE DEVELOPMENT 10 326 5.443e-07 1.154e-05
221 MACROMOLECULAR COMPLEX DISASSEMBLY 8 182 5.491e-07 1.156e-05
222 REGULATION OF HYDROLASE ACTIVITY 19 1327 5.637e-07 1.181e-05
223 LEUKOCYTE ACTIVATION 11 414 5.868e-07 1.224e-05
224 RESPONSE TO CYTOKINE 14 714 5.936e-07 1.233e-05
225 PERICARDIUM DEVELOPMENT 4 18 6.283e-07 1.299e-05
226 LEUKOCYTE CELL CELL ADHESION 9 255 6.553e-07 1.349e-05
227 TUBE FORMATION 7 129 7.121e-07 1.46e-05
228 REGULATION OF JUN KINASE ACTIVITY 6 81 7.444e-07 1.519e-05
229 REGULATION OF INTRACELLULAR TRANSPORT 13 621 7.605e-07 1.545e-05
230 KIDNEY MORPHOGENESIS 6 82 8.007e-07 1.62e-05
231 LYMPHOCYTE ACTIVATION 10 342 8.416e-07 1.695e-05
232 REGULATION OF CELL ADHESION 13 629 8.778e-07 1.761e-05
233 CONNECTIVE TISSUE DEVELOPMENT 8 194 8.901e-07 1.778e-05
234 MESENCHYMAL CELL DIFFERENTIATION 7 134 9.207e-07 1.831e-05
235 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 15 867 1.079e-06 2.137e-05
236 IMMUNE SYSTEM PROCESS 23 1984 1.144e-06 2.256e-05
237 COCHLEA MORPHOGENESIS 4 21 1.218e-06 2.391e-05
238 FOREBRAIN DEVELOPMENT 10 357 1.241e-06 2.426e-05
239 NEGATIVE REGULATION OF CATABOLIC PROCESS 8 203 1.252e-06 2.438e-05
240 RESPONSE TO ALCOHOL 10 362 1.406e-06 2.726e-05
241 POSITIVE REGULATION OF MAP KINASE ACTIVITY 8 207 1.45e-06 2.799e-05
242 SKELETAL SYSTEM DEVELOPMENT 11 455 1.478e-06 2.841e-05
243 REGULATION OF CELL PROJECTION ORGANIZATION 12 558 1.606e-06 3.074e-05
244 CARTILAGE DEVELOPMENT 7 147 1.715e-06 3.248e-05
245 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 10 370 1.711e-06 3.248e-05
246 CELLULAR COMPONENT MORPHOGENESIS 15 900 1.717e-06 3.248e-05
247 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 7 148 1.795e-06 3.367e-05
248 PEPTIDYL SERINE MODIFICATION 7 148 1.795e-06 3.367e-05
249 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 95 1.909e-06 3.568e-05
250 MAMMARY GLAND EPITHELIUM DEVELOPMENT 5 53 1.964e-06 3.655e-05
251 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 12 573 2.114e-06 3.918e-05
252 NEURON DEVELOPMENT 13 687 2.335e-06 4.303e-05
253 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 2.34e-06 4.303e-05
254 IMMUNE SYSTEM DEVELOPMENT 12 582 2.483e-06 4.548e-05
255 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 9 303 2.725e-06 4.973e-05
256 POSITIVE REGULATION OF TRANSPORT 15 936 2.784e-06 5.059e-05
257 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 26 2.998e-06 5.428e-05
258 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 229 3.077e-06 5.507e-05
259 POSITIVE REGULATION OF CATABOLIC PROCESS 10 395 3.068e-06 5.507e-05
260 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 103 3.064e-06 5.507e-05
261 REGENERATION 7 161 3.144e-06 5.605e-05
262 EPITHELIAL CELL DIFFERENTIATION 11 495 3.33e-06 5.914e-05
263 NEGATIVE REGULATION OF MOLECULAR FUNCTION 16 1079 3.352e-06 5.931e-05
264 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 8 232 3.388e-06 5.972e-05
265 REGULATION OF CATENIN IMPORT INTO NUCLEUS 4 27 3.509e-06 6.147e-05
266 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 12 602 3.514e-06 6.147e-05
267 REGULATION OF FAT CELL DIFFERENTIATION 6 106 3.622e-06 6.289e-05
268 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 3.622e-06 6.289e-05
269 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 16 1087 3.685e-06 6.375e-05
270 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 7 166 3.85e-06 6.635e-05
271 CELL CELL ADHESION 12 608 3.889e-06 6.678e-05
272 EMBRYONIC DIGIT MORPHOGENESIS 5 61 3.974e-06 6.773e-05
273 MUSCLE CELL DIFFERENTIATION 8 237 3.967e-06 6.773e-05
274 DOPAMINERGIC NEURON DIFFERENTIATION 4 28 4.081e-06 6.931e-05
275 REGULATION OF MAP KINASE ACTIVITY 9 319 4.144e-06 7.012e-05
276 REGULATION OF PROTEIN BINDING 7 168 4.167e-06 7.025e-05
277 REGULATION OF CELL CYCLE PHASE TRANSITION 9 321 4.36e-06 7.324e-05
278 POSITIVE REGULATION OF LOCOMOTION 10 420 5.279e-06 8.836e-05
279 REGULATION OF GROWTH 12 633 5.863e-06 9.736e-05
280 RESPONSE TO METAL ION 9 333 5.868e-06 9.736e-05
281 MESODERM MORPHOGENESIS 5 66 5.879e-06 9.736e-05
282 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 6.074e-06 0.0001002
283 CENTRAL NERVOUS SYSTEM DEVELOPMENT 14 872 6.147e-06 0.0001011
284 REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 4 31 6.217e-06 0.0001019
285 SPECIFICATION OF SYMMETRY 6 117 6.42e-06 0.0001041
286 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 117 6.42e-06 0.0001041
287 MAMMARY GLAND DEVELOPMENT 6 117 6.42e-06 0.0001041
288 RESPONSE TO DRUG 10 431 6.624e-06 0.000107
289 MUSCLE STRUCTURE DEVELOPMENT 10 432 6.76e-06 0.0001085
290 MESODERM DEVELOPMENT 6 118 6.743e-06 0.0001085
291 NEGATIVE REGULATION OF CELL CYCLE 10 433 6.898e-06 0.0001103
292 MITOTIC CELL CYCLE 13 766 7.623e-06 0.0001215
293 COVALENT CHROMATIN MODIFICATION 9 345 7.802e-06 0.0001239
294 NEURON PROJECTION DEVELOPMENT 11 545 8.3e-06 0.0001309
295 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 262 8.279e-06 0.0001309
296 BRAIN MORPHOGENESIS 4 34 9.082e-06 0.0001428
297 SEX DIFFERENTIATION 8 266 9.245e-06 0.0001448
298 POSITIVE REGULATION OF HYDROLASE ACTIVITY 14 905 9.378e-06 0.0001464
299 PROTEIN AUTOPHOSPHORYLATION 7 192 1.001e-05 0.0001557
300 EAR DEVELOPMENT 7 195 1.107e-05 0.0001717
301 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 7 197 1.183e-05 0.0001829
302 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 3 12 1.224e-05 0.0001886
303 NEGATIVE REGULATION OF BINDING 6 131 1.229e-05 0.0001887
304 REGULATION OF BMP SIGNALING PATHWAY 5 77 1.257e-05 0.0001924
305 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 1.283e-05 0.0001957
306 RENAL TUBULE DEVELOPMENT 5 78 1.339e-05 0.0002036
307 SKELETAL SYSTEM MORPHOGENESIS 7 201 1.348e-05 0.0002043
308 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 12 689 1.374e-05 0.0002076
309 HEMATOPOIETIC STEM CELL PROLIFERATION 3 13 1.587e-05 0.0002382
310 COCHLEA DEVELOPMENT 4 39 1.587e-05 0.0002382
311 REGULATION OF SYNAPTIC PLASTICITY 6 140 1.794e-05 0.0002684
312 LEUKOCYTE DIFFERENTIATION 8 292 1.815e-05 0.0002707
313 SKIN DEVELOPMENT 7 211 1.845e-05 0.0002742
314 POSITIVE REGULATION OF OSSIFICATION 5 84 1.923e-05 0.000285
315 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 4 41 1.943e-05 0.0002863
316 PLATELET ACTIVATION 6 142 1.944e-05 0.0002863
317 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 3 14 2.014e-05 0.0002937
318 REGULATION OF MONOCYTE DIFFERENTIATION 3 14 2.014e-05 0.0002937
319 CONVERGENT EXTENSION 3 14 2.014e-05 0.0002937
320 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 144 2.105e-05 0.000306
321 MODULATION OF SYNAPTIC TRANSMISSION 8 301 2.256e-05 0.0003271
322 MORPHOGENESIS OF AN EPITHELIAL SHEET 4 43 2.353e-05 0.0003401
323 NEGATIVE REGULATION OF DENDRITE MORPHOGENESIS 3 15 2.51e-05 0.0003616
324 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 4 44 2.581e-05 0.0003707
325 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 11 616 2.589e-05 0.0003707
326 PROTEIN COMPLEX BIOGENESIS 15 1132 2.698e-05 0.0003828
327 MIDBRAIN DEVELOPMENT 5 90 2.688e-05 0.0003828
328 PROTEIN COMPLEX ASSEMBLY 15 1132 2.698e-05 0.0003828
329 HEMOSTASIS 8 311 2.849e-05 0.000403
330 PALLIUM DEVELOPMENT 6 153 2.964e-05 0.0004179
331 TELENCEPHALON DEVELOPMENT 7 228 3.033e-05 0.0004264
332 PEPTIDYL THREONINE MODIFICATION 4 46 3.084e-05 0.0004297
333 POSITIVE REGULATION OF LAMELLIPODIUM ASSEMBLY 3 16 3.081e-05 0.0004297
334 CELLULAR COMPONENT DISASSEMBLY 10 515 3.077e-05 0.0004297
335 CHROMOSOME ORGANIZATION 14 1009 3.154e-05 0.0004368
336 NEPHRON EPITHELIUM DEVELOPMENT 5 93 3.15e-05 0.0004368
337 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 3.306e-05 0.0004564
338 DIGESTIVE TRACT MORPHOGENESIS 4 48 3.656e-05 0.0005033
339 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 17 3.731e-05 0.0005105
340 ESTABLISHMENT OF TISSUE POLARITY 3 17 3.731e-05 0.0005105
341 CELL CELL SIGNALING 12 767 3.945e-05 0.0005383
342 POSITIVE REGULATION OF GROWTH 7 238 3.986e-05 0.0005424
343 ACTIVATION OF IMMUNE RESPONSE 9 427 4.201e-05 0.0005699
344 CELL PROJECTION ORGANIZATION 13 902 4.254e-05 0.0005754
345 POSITIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 50 4.302e-05 0.0005802
346 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 100 4.467e-05 0.0005956
347 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 4.464e-05 0.0005956
348 UTERUS DEVELOPMENT 3 18 4.464e-05 0.0005956
349 SIGNAL TRANSDUCTION INVOLVED IN REGULATION OF GENE EXPRESSION 3 18 4.464e-05 0.0005956
350 CHROMATIN MODIFICATION 10 539 4.519e-05 0.0006008
351 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 7 246 4.916e-05 0.0006498
352 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 102 4.912e-05 0.0006498
353 POSITIVE REGULATION OF CELL CYCLE PROCESS 7 247 5.043e-05 0.0006642
354 CHROMATIN ORGANIZATION 11 663 5.053e-05 0.0006642
355 REGULATION OF CIRCADIAN RHYTHM 5 103 5.147e-05 0.0006728
356 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 5 103 5.147e-05 0.0006728
357 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 5.391e-05 0.0007026
358 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 4 53 5.421e-05 0.0007027
359 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 5.421e-05 0.0007027
360 COGNITION 7 251 5.582e-05 0.0007214
361 CEREBRAL CORTEX DEVELOPMENT 5 105 5.643e-05 0.0007274
362 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 5.892e-05 0.0007569
363 FAT CELL DIFFERENTIATION 5 106 5.905e-05 0.0007569
364 CELL CYCLE PHASE TRANSITION 7 255 6.166e-05 0.0007882
365 TRACHEA DEVELOPMENT 3 20 6.202e-05 0.0007906
366 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 5 108 6.456e-05 0.0008207
367 REGULATION OF CYTOKINE PRODUCTION 10 563 6.505e-05 0.0008225
368 POSITIVE REGULATION OF IMMUNE RESPONSE 10 563 6.505e-05 0.0008225
369 SMAD PROTEIN SIGNAL TRANSDUCTION 4 56 6.74e-05 0.0008476
370 OUTFLOW TRACT MORPHOGENESIS 4 56 6.74e-05 0.0008476
371 REGULATION OF OSSIFICATION 6 178 6.901e-05 0.0008655
372 FORMATION OF PRIMARY GERM LAYER 5 110 7.045e-05 0.0008812
373 MYOTUBE DIFFERENTIATION 4 57 7.227e-05 0.0008992
374 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 7.227e-05 0.0008992
375 CELLULAR RESPONSE TO ABIOTIC STIMULUS 7 263 7.486e-05 0.0009288
376 REGULATION OF OSTEOBLAST DIFFERENTIATION 5 112 7.676e-05 0.0009499
377 REGULATION OF SECRETION 11 699 8.115e-05 0.001002
378 MACROMOLECULAR COMPLEX ASSEMBLY 16 1398 8.194e-05 0.001009
379 SOMATIC STEM CELL DIVISION 3 22 8.331e-05 0.001023
380 POSITIVE REGULATION OF PROTEOLYSIS 8 363 8.456e-05 0.001035
381 BLOOD VESSEL MORPHOGENESIS 8 364 8.619e-05 0.001053
382 NEPHRON DEVELOPMENT 5 115 8.702e-05 0.001057
383 RESPONSE TO CALCIUM ION 5 115 8.702e-05 0.001057
384 NEGATIVE REGULATION OF CELL DIVISION 4 60 8.843e-05 0.001072
385 CELL MOTILITY 12 835 8.911e-05 0.001074
386 LOCALIZATION OF CELL 12 835 8.911e-05 0.001074
387 PROTEASOMAL PROTEIN CATABOLIC PROCESS 7 271 9.028e-05 0.001085
388 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 8 368 9.297e-05 0.001115
389 SCF DEPENDENT PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 3 23 9.553e-05 0.001143
390 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 0.0001018 0.001215
391 REGULATION OF PROTEIN COMPLEX ASSEMBLY 8 375 0.0001059 0.001257
392 REGULATION OF CHROMOSOME ORGANIZATION 7 278 0.0001058 0.001257
393 REGULATION OF DENDRITE DEVELOPMENT 5 120 0.0001064 0.00126
394 REGULATION OF EPIDERMIS DEVELOPMENT 4 63 0.0001071 0.001261
395 REGULATION OF MUSCLE ADAPTATION 4 63 0.0001071 0.001261
396 POSITIVE REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 3 24 0.0001089 0.001276
397 POSITIVE REGULATION OF LAMELLIPODIUM ORGANIZATION 3 24 0.0001089 0.001276
398 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 724 0.0001108 0.001292
399 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 0.0001107 0.001292
400 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 5 122 0.0001151 0.001338
401 POSITIVE REGULATION OF MITOTIC CELL CYCLE 5 123 0.0001196 0.001384
402 T CELL DIFFERENTIATION 5 123 0.0001196 0.001384
403 LENS FIBER CELL DIFFERENTIATION 3 25 0.0001234 0.001421
404 SPINDLE CHECKPOINT 3 25 0.0001234 0.001421
405 REPRODUCTION 15 1297 0.0001265 0.001454
406 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 6 199 0.0001275 0.001461
407 CELLULAR RESPONSE TO UV 4 66 0.0001284 0.001464
408 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 0.0001284 0.001464
409 RESPONSE TO STEROID HORMONE 9 497 0.0001339 0.00152
410 REGULATION OF DEVELOPMENTAL GROWTH 7 289 0.0001346 0.00152
411 APOPTOTIC SIGNALING PATHWAY 7 289 0.0001346 0.00152
412 RESPONSE TO UV 5 126 0.0001339 0.00152
413 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 4 67 0.0001362 0.00153
414 REGULATION OF SISTER CHROMATID SEGREGATION 4 67 0.0001362 0.00153
415 REGULATION OF CELL GROWTH 8 391 0.0001412 0.001583
416 REGULATION OF PHOSPHATASE ACTIVITY 5 128 0.0001442 0.00161
417 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 68 0.0001442 0.00161
418 ACTIVATION OF INNATE IMMUNE RESPONSE 6 204 0.0001459 0.001625
419 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 129 0.0001496 0.001661
420 CELLULAR RESPONSE TO NITROGEN COMPOUND 9 505 0.000151 0.001673
421 REGULATION OF BODY FLUID LEVELS 9 506 0.0001533 0.001694
422 SKELETAL MUSCLE TISSUE REGENERATION 3 27 0.000156 0.001712
423 REGULATION OF LAMELLIPODIUM ASSEMBLY 3 27 0.000156 0.001712
424 RESPONSE TO LITHIUM ION 3 27 0.000156 0.001712
425 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 207 0.000158 0.00173
426 PROTEIN LOCALIZATION 18 1805 0.0001598 0.001745
427 LYMPHOCYTE DIFFERENTIATION 6 209 0.0001665 0.001814
428 NEURON PROJECTION MORPHOGENESIS 8 402 0.0001707 0.001856
429 GASTRULATION WITH MOUTH FORMING SECOND 3 28 0.0001743 0.001877
430 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 3 28 0.0001743 0.001877
431 NEGATIVE REGULATION OF DENDRITE DEVELOPMENT 3 28 0.0001743 0.001877
432 MORPHOGENESIS OF A POLARIZED EPITHELIUM 3 28 0.0001743 0.001877
433 NEGATIVE REGULATION OF CELL DEVELOPMENT 7 303 0.00018 0.001935
434 REGULATION OF NEURON PROJECTION DEVELOPMENT 8 408 0.0001888 0.002024
435 PANCREAS DEVELOPMENT 4 73 0.00019 0.002032
436 STEM CELL DIVISION 3 29 0.0001938 0.002068
437 HINDBRAIN DEVELOPMENT 5 137 0.0001981 0.00211
438 REGULATION OF DENDRITE MORPHOGENESIS 4 74 0.0002002 0.002127
439 RESPONSE TO OXYGEN LEVELS 7 311 0.0002112 0.002233
440 NEURAL CREST CELL DIFFERENTIATION 4 75 0.0002109 0.002233
441 REGULATION OF CELLULAR RESPONSE TO HEAT 4 76 0.0002219 0.002342
442 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 5 141 0.0002265 0.002385
443 DIENCEPHALON DEVELOPMENT 4 77 0.0002334 0.002452
444 SYNAPTIC SIGNALING 8 424 0.000245 0.002567
445 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 9 541 0.000252 0.002629
446 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 9 541 0.000252 0.002629
447 NEGATIVE REGULATION OF PROTEIN BINDING 4 79 0.0002576 0.002682
448 RESPONSE TO ESTRADIOL 5 146 0.0002663 0.002766
449 REGULATION OF GTPASE ACTIVITY 10 673 0.0002784 0.002886
450 REGULATION OF FIBROBLAST PROLIFERATION 4 81 0.0002836 0.002926
451 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 4 81 0.0002836 0.002926
452 CELLULAR RESPONSE TO HORMONE STIMULUS 9 552 0.0002922 0.003008
453 NEGATIVE REGULATION OF PROTEOLYSIS 7 329 0.0002972 0.003047
454 JNK CASCADE 4 82 0.0002973 0.003047
455 REGULATION OF NEURON DIFFERENTIATION 9 554 0.0003001 0.003069
456 REGULATION OF MESENCHYMAL CELL PROLIFERATION 3 34 0.000313 0.00318
457 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 3 34 0.000313 0.00318
458 NEURAL TUBE PATTERNING 3 34 0.000313 0.00318
459 NEGATIVE REGULATION OF GROWTH 6 236 0.0003203 0.003247
460 CELL CYCLE ARREST 5 154 0.0003406 0.003431
461 AMEBOIDAL TYPE CELL MIGRATION 5 154 0.0003406 0.003431
462 REGULATION OF CHROMOSOME SEGREGATION 4 85 0.0003411 0.003431
463 BONE REMODELING 3 35 0.0003414 0.003431
464 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 5 156 0.0003614 0.003616
465 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0003614 0.003616
466 HEAD MORPHOGENESIS 3 36 0.0003714 0.003708
467 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 14 1275 0.0003734 0.00372
468 REGULATION OF DEPHOSPHORYLATION 5 158 0.0003832 0.00381
469 REGULATION OF STEM CELL PROLIFERATION 4 88 0.0003894 0.003863
470 PEPTIDYL AMINO ACID MODIFICATION 11 841 0.0004036 0.003979
471 REGULATION OF MUSCLE HYPERTROPHY 3 37 0.000403 0.003979
472 REGULATION OF LAMELLIPODIUM ORGANIZATION 3 37 0.000403 0.003979
473 CELL DIVISION 8 460 0.0004224 0.004156
474 REGULATION OF CELL MATRIX ADHESION 4 90 0.0004242 0.004164
475 SYSTEM PROCESS 17 1785 0.0004337 0.004248
476 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 38 0.0004363 0.004265
477 REGULATION OF NUCLEAR DIVISION 5 163 0.0004419 0.004306
478 CELLULAR RESPONSE TO LIGHT STIMULUS 4 91 0.0004424 0.004306
479 TAXIS 8 464 0.0004474 0.004346
480 CELL SUBSTRATE ADHESION 5 164 0.0004544 0.004405
481 REGULATION OF EPITHELIAL CELL MIGRATION 5 166 0.0004803 0.004646
482 REGULATION OF INNATE IMMUNE RESPONSE 7 357 0.0004851 0.004683
483 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0005081 0.004855
484 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 0.0005081 0.004855
485 RESPONSE TO CARBOHYDRATE 5 168 0.0005072 0.004855
486 HINDBRAIN MORPHOGENESIS 3 40 0.0005081 0.004855
487 REGULATION OF AXONOGENESIS 5 168 0.0005072 0.004855
488 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 4 95 0.0005208 0.004966
489 NEGATIVE REGULATION OF CELL GROWTH 5 170 0.0005353 0.005093
490 NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION 4 96 0.0005418 0.005145
491 REGULATION OF HORMONE LEVELS 8 478 0.0005442 0.005149
492 POSITIVE REGULATION OF DEFENSE RESPONSE 7 364 0.0005444 0.005149
493 REGULATION OF HORMONE SECRETION 6 262 0.0005572 0.005259
494 CELLULAR RESPONSE TO CYTOKINE STIMULUS 9 606 0.0005751 0.005417
495 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 3 42 0.0005871 0.005508
496 GENITALIA DEVELOPMENT 3 42 0.0005871 0.005508
497 HOMEOSTATIC PROCESS 14 1337 0.0006006 0.0056
498 POSITIVE REGULATION OF CYTOKINE PRODUCTION 7 370 0.0005998 0.0056
499 POSITIVE REGULATION OF SECRETION 7 370 0.0005998 0.0056
500 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 99 0.0006086 0.005652
501 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 99 0.0006086 0.005652
502 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 3 43 0.0006294 0.005834
503 METENCEPHALON DEVELOPMENT 4 100 0.0006321 0.005847
504 POSITIVE REGULATION OF CELL ADHESION 7 376 0.0006595 0.006089
505 BODY MORPHOGENESIS 3 44 0.0006736 0.006206
506 REGULATION OF CELL DIVISION 6 272 0.0006779 0.006234
507 REGULATION OF CHEMOTAXIS 5 180 0.0006934 0.006364
508 REGULATION OF CELL CELL ADHESION 7 380 0.0007019 0.006429
509 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 4 103 0.0007064 0.006458
510 REGULATION OF DEFENSE RESPONSE 10 759 0.0007137 0.006511
511 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 4 104 0.0007325 0.00667
512 SINGLE ORGANISM BEHAVIOR 7 384 0.0007464 0.006776
513 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 0.0007471 0.006776
514 NEGATIVE REGULATION OF DNA BINDING 3 46 0.0007677 0.006936
515 NEGATIVE REGULATION OF NUCLEAR DIVISION 3 46 0.0007677 0.006936
516 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 0.0007739 0.006979
517 CELL PART MORPHOGENESIS 9 633 0.0007845 0.007047
518 POSITIVE REGULATION OF DNA METABOLIC PROCESS 5 185 0.0007845 0.007047
519 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 6 280 0.0007884 0.007055
520 RESPONSE TO LIGHT STIMULUS 6 280 0.0007884 0.007055
521 EPITHELIAL CELL DEVELOPMENT 5 186 0.0008038 0.007154
522 PRIMITIVE STREAK FORMATION 2 11 0.0008072 0.007154
523 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 2 11 0.0008072 0.007154
524 OLFACTORY BULB INTERNEURON DEVELOPMENT 2 11 0.0008072 0.007154
525 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 2 11 0.0008072 0.007154
526 MUSCLE FIBER DEVELOPMENT 3 47 0.0008178 0.007234
527 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.0008734 0.007711
528 PROTEIN DEPHOSPHORYLATION 5 190 0.0008843 0.007793
529 BEHAVIOR 8 516 0.0008954 0.007876
530 REGULATION OF NEURONAL SYNAPTIC PLASTICITY 3 49 0.000924 0.008097
531 CELLULAR RESPONSE TO CALCIUM ION 3 49 0.000924 0.008097
532 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 5 192 0.0009267 0.008105
533 KERATINOCYTE PROLIFERATION 2 12 0.0009662 0.008341
534 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.0009662 0.008341
535 CARTILAGE MORPHOGENESIS 2 12 0.0009662 0.008341
536 ROSTROCAUDAL NEURAL TUBE PATTERNING 2 12 0.0009662 0.008341
537 TRACHEA MORPHOGENESIS 2 12 0.0009662 0.008341
538 EMBRYONIC CAMERA TYPE EYE FORMATION 2 12 0.0009662 0.008341
539 LENS FIBER CELL DEVELOPMENT 2 12 0.0009662 0.008341
540 REGULATION OF ADHERENS JUNCTION ORGANIZATION 3 50 0.0009802 0.008431
541 FACE DEVELOPMENT 3 50 0.0009802 0.008431
542 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 5 195 0.0009932 0.008526
543 ANGIOGENESIS 6 293 0.0009971 0.008544
544 REGULATION OF SYNAPSE ORGANIZATION 4 113 0.000999 0.008545
545 REGULATION OF ENDOTHELIAL CELL MIGRATION 4 114 0.001032 0.008813
546 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 3 51 0.001039 0.008842
547 RESPIRATORY SYSTEM DEVELOPMENT 5 197 0.001039 0.008842
548 RESPONSE TO INTERLEUKIN 1 4 115 0.001066 0.009054
549 TISSUE REGENERATION 3 52 0.001099 0.009315
550 RESPONSE TO RADIATION 7 413 0.00114 0.009629
551 REGULATION OF SKELETAL MUSCLE ADAPTATION 2 13 0.001139 0.009629
552 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 3 53 0.001162 0.009793
NumGOOverlapSizeP ValueAdj. P Value
1 BETA CATENIN BINDING 16 84 2.891e-23 1.685e-20
2 FRIZZLED BINDING 13 36 3.627e-23 1.685e-20
3 WNT PROTEIN BINDING 8 31 2.715e-13 8.409e-11
4 WNT ACTIVATED RECEPTOR ACTIVITY 7 22 1.695e-12 3.937e-10
5 ENZYME BINDING 29 1737 4.178e-12 7.763e-10
6 PROTEIN SERINE THREONINE KINASE ACTIVITY 16 445 1.342e-11 2.078e-09
7 RECEPTOR AGONIST ACTIVITY 6 16 2.245e-11 2.361e-09
8 PROTEIN DOMAIN SPECIFIC BINDING 18 624 2.288e-11 2.361e-09
9 G PROTEIN COUPLED RECEPTOR BINDING 13 259 2.225e-11 2.361e-09
10 TRANSCRIPTION FACTOR BINDING 16 524 1.511e-10 1.404e-08
11 PROTEIN KINASE ACTIVITY 17 640 3.194e-10 2.698e-08
12 RECEPTOR ACTIVATOR ACTIVITY 6 32 2.418e-09 1.872e-07
13 RECEPTOR BINDING 23 1476 5.16e-09 3.688e-07
14 SIGNAL TRANSDUCER ACTIVITY 24 1731 2.127e-08 1.235e-06
15 KINASE ACTIVITY 17 842 1.958e-08 1.235e-06
16 RECEPTOR REGULATOR ACTIVITY 6 45 2.088e-08 1.235e-06
17 MOLECULAR FUNCTION REGULATOR 21 1353 3.074e-08 1.68e-06
18 UBIQUITIN LIKE PROTEIN LIGASE BINDING 10 264 7.746e-08 3.998e-06
19 REGULATORY REGION NUCLEIC ACID BINDING 16 818 8.474e-08 4.143e-06
20 GAMMA CATENIN BINDING 4 12 1.035e-07 4.806e-06
21 ARMADILLO REPEAT DOMAIN BINDING 4 13 1.49e-07 6.592e-06
22 CORE PROMOTER PROXIMAL REGION DNA BINDING 11 371 1.976e-07 8.343e-06
23 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 17 992 2.082e-07 8.409e-06
24 PROTEIN DIMERIZATION ACTIVITY 18 1149 3.231e-07 1.251e-05
25 SMAD BINDING 6 72 3.685e-07 1.369e-05
26 PDZ DOMAIN BINDING 6 90 1.389e-06 4.963e-05
27 R SMAD BINDING 4 23 1.791e-06 6.164e-05
28 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 6 104 3.242e-06 0.0001076
29 KINASE BINDING 12 606 3.76e-06 0.0001205
30 RECEPTOR SIGNALING PROTEIN ACTIVITY 7 172 4.867e-06 0.0001507
31 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 328 5.193e-06 0.0001556
32 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 12 629 5.497e-06 0.0001596
33 I SMAD BINDING 3 11 9.206e-06 0.0002592
34 CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY 3 12 1.224e-05 0.0003344
35 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 16 1199 1.272e-05 0.0003376
36 RHO GTPASE BINDING 5 78 1.339e-05 0.0003456
37 MAP KINASE ACTIVITY 3 14 2.014e-05 0.0005056
38 PROTEIN HOMODIMERIZATION ACTIVITY 12 722 2.185e-05 0.0005341
39 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 7 226 2.867e-05 0.0006829
40 PROTEIN KINASE C ACTIVITY 3 16 3.081e-05 0.0007155
41 SEQUENCE SPECIFIC DNA BINDING 14 1037 4.254e-05 0.000964
42 ADENYL NUCLEOTIDE BINDING 17 1514 5.966e-05 0.00132
43 RIBONUCLEOTIDE BINDING 19 1860 7.271e-05 0.001535
44 ACTIVATING TRANSCRIPTION FACTOR BINDING 4 57 7.227e-05 0.001535
45 PROTEIN HETERODIMERIZATION ACTIVITY 9 468 8.498e-05 0.001754
46 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 9.322e-05 0.001883
47 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 0.0001139 0.002251
48 DOUBLE STRANDED DNA BINDING 11 764 0.0001774 0.003433
49 IDENTICAL PROTEIN BINDING 14 1209 0.0002169 0.004112
50 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 7 315 0.0002283 0.004241
51 ENZYME REGULATOR ACTIVITY 12 959 0.0003222 0.005869
52 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 3 36 0.0003714 0.006635
53 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 4 92 0.0004611 0.008083
54 ENHANCER BINDING 4 93 0.0004804 0.008265
55 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 5 168 0.0005072 0.008567
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALOSOME 5 11 3.593e-10 2.098e-07
2 NUCLEAR CHROMATIN 12 291 1.326e-09 3.003e-07
3 BETA CATENIN DESTRUCTION COMPLEX 5 14 1.543e-09 3.003e-07
4 ENDOCYTIC VESICLE MEMBRANE 9 152 7.777e-09 1.135e-06
5 CHROMATIN 13 441 1.466e-08 1.712e-06
6 TRANSCRIPTION FACTOR COMPLEX 11 298 2.144e-08 2.087e-06
7 PHOSPHATASE COMPLEX 6 48 3.117e-08 2.6e-06
8 ENDOCYTIC VESICLE 10 256 5.806e-08 4.239e-06
9 CHROMOSOME 16 880 2.287e-07 1.484e-05
10 CATALYTIC COMPLEX 17 1038 3.944e-07 2.303e-05
11 NUCLEAR CHROMOSOME 12 523 8.158e-07 4.331e-05
12 PROTEIN PHOSPHATASE TYPE 2A COMPLEX 4 20 9.889e-07 4.813e-05
13 INTRACELLULAR VESICLE 17 1259 5.522e-06 0.0002481
14 TRANSCRIPTIONAL REPRESSOR COMPLEX 5 74 1.034e-05 0.0004027
15 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 1.003e-05 0.0004027
16 VESICLE MEMBRANE 10 512 2.928e-05 0.001069
17 SYNAPSE 12 754 3.341e-05 0.001084
18 GOLGI LUMEN 5 94 3.317e-05 0.001084
19 EXTRACELLULAR MATRIX 9 426 4.125e-05 0.001256
20 LATERAL PLASMA MEMBRANE 4 50 4.302e-05 0.001256
21 CYTOPLASMIC VESICLE PART 10 601 0.0001116 0.003103
22 SYNAPSE PART 10 610 0.000126 0.003345
23 SCF UBIQUITIN LIGASE COMPLEX 3 34 0.000313 0.007947
24 PROTEIN KINASE COMPLEX 4 90 0.0004242 0.009909
25 MEMBRANE REGION 13 1134 0.0004128 0.009909

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 78 387 6.395e-138 1.132e-135
2 hsa04916_Melanogenesis 32 387 1.438e-34 1.273e-32
3 hsa04010_MAPK_signaling_pathway 18 387 7.192e-15 4.244e-13
4 hsa04114_Oocyte_meiosis 14 387 2.72e-10 8.023e-09
5 hsa04340_Hedgehog_signaling_pathway 14 387 2.72e-10 8.023e-09
6 hsa04520_Adherens_junction 14 387 2.72e-10 8.023e-09
7 hsa04720_Long.term_potentiation 13 387 3.086e-09 7.804e-08
8 hsa04020_Calcium_signaling_pathway 12 387 3.198e-08 6.29e-07
9 hsa04510_Focal_adhesion 12 387 3.198e-08 6.29e-07
10 hsa04912_GnRH_signaling_pathway 11 387 3.01e-07 5.328e-06
11 hsa04012_ErbB_signaling_pathway 10 387 2.557e-06 3.018e-05
12 hsa04110_Cell_cycle 10 387 2.557e-06 3.018e-05
13 hsa04370_VEGF_signaling_pathway 10 387 2.557e-06 3.018e-05
14 hsa04650_Natural_killer_cell_mediated_cytotoxicity 10 387 2.557e-06 3.018e-05
15 hsa04662_B_cell_receptor_signaling_pathway 10 387 2.557e-06 3.018e-05
16 hsa04062_Chemokine_signaling_pathway 9 387 1.947e-05 0.0001723
17 hsa04350_TGF.beta_signaling_pathway 9 387 1.947e-05 0.0001723
18 hsa04360_Axon_guidance 9 387 1.947e-05 0.0001723
19 hsa04660_T_cell_receptor_signaling_pathway 9 387 1.947e-05 0.0001723
20 hsa04971_Gastric_acid_secretion 9 387 1.947e-05 0.0001723
21 hsa04270_Vascular_smooth_muscle_contraction 8 387 0.0001316 0.001013
22 hsa04380_Osteoclast_differentiation 8 387 0.0001316 0.001013
23 hsa04722_Neurotrophin_signaling_pathway 8 387 0.0001316 0.001013
24 hsa04540_Gap_junction 7 387 0.0007812 0.005531
25 hsa04970_Salivary_secretion 7 387 0.0007812 0.005531
26 hsa04210_Apoptosis 6 387 0.004021 0.02372
27 hsa04530_Tight_junction 6 387 0.004021 0.02372
28 hsa04664_Fc_epsilon_RI_signaling_pathway 6 387 0.004021 0.02372
29 hsa04670_Leukocyte_transendothelial_migration 6 387 0.004021 0.02372
30 hsa04910_Insulin_signaling_pathway 6 387 0.004021 0.02372
31 hsa04330_Notch_signaling_pathway 5 387 0.01764 0.083
32 hsa04620_Toll.like_receptor_signaling_pathway 5 387 0.01764 0.083
33 hsa04666_Fc_gamma_R.mediated_phagocytosis 5 387 0.01764 0.083
34 hsa04730_Long.term_depression 5 387 0.01764 0.083
35 hsa04810_Regulation_of_actin_cytoskeleton 5 387 0.01764 0.083
36 hsa04914_Progesterone.mediated_oocyte_maturation 5 387 0.01764 0.083
37 hsa04972_Pancreatic_secretion 5 387 0.01764 0.083
38 hsa04740_Olfactory_transduction 5 388 0.01782 0.083
39 hsa04070_Phosphatidylinositol_signaling_system 4 387 0.0646 0.2789
40 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 387 0.0646 0.2789
41 hsa04630_Jak.STAT_signaling_pathway 4 387 0.0646 0.2789
42 hsa03015_mRNA_surveillance_pathway 3 387 0.192 0.6797
43 hsa04120_Ubiquitin_mediated_proteolysis 3 387 0.192 0.6797
44 hsa04621_NOD.like_receptor_signaling_pathway 3 387 0.192 0.6797
45 hsa04622_RIG.I.like_receptor_signaling_pathway 3 387 0.192 0.6797
46 hsa04710_Circadian_rhythm_._mammal 3 387 0.192 0.6797
47 hsa04742_Taste_transduction 3 387 0.192 0.6797
48 hsa04960_Aldosterone.regulated_sodium_reabsorption 3 387 0.192 0.6797
49 hsa04962_Vasopressin.regulated_water_reabsorption 3 387 0.192 0.6797
50 hsa04976_Bile_secretion 3 387 0.192 0.6797
51 hsa03008_Ribosome_biogenesis_in_eukaryotes 2 387 0.4473 1
52 hsa04115_p53_signaling_pathway 2 387 0.4473 1
53 hsa04144_Endocytosis 2 387 0.4473 1
54 hsa04920_Adipocytokine_signaling_pathway 2 387 0.4473 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 PTOV1-AS1 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-92a-3p 11 PRKCA Sponge network -0.074 0.84862 -0.093 0.86855 0.499
2 ALDH1L1-AS2 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p 10 PRKCA Sponge network 0.044 0.93158 -0.093 0.86855 0.468
3 LINC00886 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 10 PRKCA Sponge network 0.196 0.7299 -0.093 0.86855 0.401
4 LAMTOR5-AS1 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p 10 PRKCA Sponge network 0.011 0.9823 -0.093 0.86855 0.382
5 ADORA2A-AS1 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-92a-3p 10 PRKCA Sponge network 0.296 0.58272 -0.093 0.86855 0.369
6 RP11-798K3.2 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 10 PRKCA Sponge network 0.217 0.77181 -0.093 0.86855 0.368
7 HOXA-AS2 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 10 PRKCA Sponge network -0.046 0.91915 -0.093 0.86855 0.358
8 LINC00559 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 10 PRKCA Sponge network 0.04 0.91022 -0.093 0.86855 0.32
9 RP11-6N17.4 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p 10 PRKCA Sponge network 0.195 0.73464 -0.093 0.86855 0.313
10 TMEM254-AS1 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 11 PRKCA Sponge network 0.03 0.94824 -0.093 0.86855 0.288
11 RP11-46C24.7 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p;hsa-miR-375 11 PRKCA Sponge network -0.039 0.92939 -0.093 0.86855 0.274
12 PART1 hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-150-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-183-5p;hsa-miR-200c-3p;hsa-miR-214-3p;hsa-miR-218-5p 10 PRKCA Sponge network -0.062 0.88185 -0.093 0.86855 0.256

Quest ID: 6f0009c8d2c7a029847cce20f9816b6a