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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-326 ABCC6P1 -1 0 2.57 0 miRanda -0.16 0.0077 NA
2 hsa-miR-326 ADAMTS10 -1 0 0.87 0 mirMAP -0.12 0.00014 NA
3 hsa-miR-326 ADAMTS13 -1 0 -0.52 0 mirMAP -0.12 0 NA
4 hsa-miR-326 ADAMTS18 -1 0 2.15 0 miRanda -0.17 0.01252 NA
5 hsa-miR-326 ADRA2C -1 0 1.34 0 miRanda -0.13 0.01139 NA
6 hsa-miR-326 AGTRAP -1 0 0.69 0 miRanda -0.13 0 NA
7 hsa-miR-326 ALOX12P2 -1 0 0.18 0.46479 miRanda -0.15 0.01217 NA
8 hsa-miR-326 ALS2CL -1 0 0.53 0 MirTarget; miRanda; mirMAP -0.15 0 NA
9 hsa-miR-326 AMIGO2 -1 0 2.15 0 miRanda -0.16 0.00114 NA
10 hsa-miR-326 ANKS3 -1 0 -0.17 0.03751 miRNATAP -0.13 0 NA
11 hsa-miR-326 ANKS6 -1 0 0.59 0 MirTarget; miRNATAP -0.1 0 NA
12 hsa-miR-326 AP1M2 -1 0 0.6 0 miRNATAP -0.14 0 NA
13 hsa-miR-326 ARHGEF16 -1 0 0.44 0 miRanda -0.12 0 NA
14 hsa-miR-326 ARMCX3 -1 0 1.37 0 miRanda -0.11 0.00874 NA
15 hsa-miR-326 ARRDC1 -1 0 0.63 0 miRNAWalker2 validate -0.11 0 NA
16 hsa-miR-326 ARVCF -1 0 -0.17 0.02818 MirTarget -0.12 0 NA
17 hsa-miR-326 B3GAT1 -1 0 1.9 0 mirMAP -0.23 0 NA
18 hsa-miR-326 BAD -1 0 0 0.95538 miRanda -0.11 0 NA
19 hsa-miR-326 BMF -1 0 0.53 1.0E-5 mirMAP -0.12 7.0E-5 NA
20 hsa-miR-326 BSG -1 0 0.44 0 miRanda -0.12 0 NA
21 hsa-miR-326 C11orf49 -1 0 0.81 0 miRNATAP -0.15 0 NA
22 hsa-miR-326 C16orf45 -1 0 1.68 0 PITA; miRNATAP -0.18 0 NA
23 hsa-miR-326 C19orf25 -1 0 -0.02 0.79771 mirMAP -0.11 0 NA
24 hsa-miR-326 C1orf159 -1 0 0.15 0.05632 mirMAP -0.14 0 NA
25 hsa-miR-326 C2CD4C -1 0 1.25 0 miRanda; mirMAP -0.24 7.0E-5 NA
26 hsa-miR-326 CACNA1I -1 0 -1.11 0 mirMAP -0.2 0.0012 NA
27 hsa-miR-326 CAPN10 -1 0 0.24 0.00016 miRanda -0.12 0 NA
28 hsa-miR-326 CAPN12 -1 0 1.01 0 PITA; miRanda; miRNATAP -0.19 0 NA
29 hsa-miR-326 CAPN3 -1 0 1.19 0 miRanda -0.19 5.0E-5 NA
30 hsa-miR-326 CASKIN1 -1 0 0.48 0.00354 MirTarget; PITA; miRanda -0.16 6.0E-5 NA
31 hsa-miR-326 CBX2 -1 0 1.51 0 miRanda -0.11 4.0E-5 NA
32 hsa-miR-326 CC2D1A -1 0 0.48 0 mirMAP -0.11 0 NA
33 hsa-miR-326 CCDC120 -1 0 0.54 0 miRanda -0.1 0 NA
34 hsa-miR-326 CCDC130 -1 0 0.01 0.84425 miRanda -0.11 0 NA
35 hsa-miR-326 CCDC74B -1 0 -0.55 1.0E-5 miRanda -0.17 0 NA
36 hsa-miR-326 CCDC84 -1 0 0.31 0.00035 miRanda -0.14 0 NA
37 hsa-miR-326 CDC42EP1 -1 0 1.34 0 MirTarget -0.14 1.0E-5 NA
38 hsa-miR-326 CDH22 -1 0 2.21 0 miRanda; miRNATAP -0.24 0.00886 NA
39 hsa-miR-326 CDH3 -1 0 3.87 0 MirTarget; miRanda; miRNATAP -0.25 0.00073 NA
40 hsa-miR-326 CDK18 -1 0 0.4 0 mirMAP -0.1 0 NA
41 hsa-miR-326 CDK9 -1 0 0.54 0 miRanda -0.11 0 NA
42 hsa-miR-326 CEACAM19 -1 0 -0.27 0.04852 miRanda -0.13 0.00015 NA
43 hsa-miR-326 CHD5 -1 0 1.07 0 mirMAP -0.16 0.00252 NA
44 hsa-miR-326 CHTF18 -1 0 0.4 3.0E-5 miRanda -0.15 0 NA
45 hsa-miR-326 CILP2 -1 0 0.56 0.00025 miRanda -0.13 0.00049 NA
46 hsa-miR-326 CLDN16 -1 0 4.67 0 MirTarget -0.24 0.0288 NA
47 hsa-miR-326 CLU -1 0 0.99 0 miRanda; miRNATAP -0.15 0.00723 NA
48 hsa-miR-326 CNTD2 -1 0 1.39 0 miRanda -0.12 0.01378 NA
49 hsa-miR-326 CPNE1 -1 0 0.32 0 miRanda -0.1 0 NA
50 hsa-miR-326 CRHR1 -1 0 0.67 0.00455 miRanda; miRNATAP -0.18 0.00274 NA
51 hsa-miR-326 CROCC -1 0 0.33 2.0E-5 MirTarget; miRanda -0.1 0 NA
52 hsa-miR-326 CRTC1 -1 0 0.39 0 mirMAP -0.15 0 NA
53 hsa-miR-326 CSPG4 -1 0 1.45 0 miRanda -0.11 0.00515 NA
54 hsa-miR-326 CYP2E1 -1 0 0.23 0.17881 miRanda -0.18 1.0E-5 NA
55 hsa-miR-326 CYP4F11 -1 0 0.37 0.42096 miRanda -0.28 0.01396 NA
56 hsa-miR-326 DAB2IP -1 0 0.92 0 MirTarget -0.13 0 NA
57 hsa-miR-326 DAPK2 -1 0 1.36 0 miRanda -0.2 1.0E-5 NA
58 hsa-miR-326 DGCR6 -1 0 0.68 0.00018 miRanda; miRNATAP -0.13 0.00389 NA
59 hsa-miR-326 DGCR6L -1 0 0.19 0.01328 miRanda -0.13 0 NA
60 hsa-miR-326 DLEC1 -1 0 0.54 0.01398 miRanda -0.15 0.00572 NA
61 hsa-miR-326 DLGAP4 -1 0 0.82 0 miRNATAP -0.1 0 NA
62 hsa-miR-326 DLX4 -1 0 0.72 0.00014 miRanda -0.13 0.00539 NA
63 hsa-miR-326 DMBX1 -1 0 5.08 0 miRanda -0.27 0.03403 NA
64 hsa-miR-326 DNLZ -1 0 0.44 0.0001 mirMAP -0.13 0 NA
65 hsa-miR-326 DTX4 -1 0 2.68 0 miRNATAP -0.18 0.00456 NA
66 hsa-miR-326 ECM1 -1 0 2.79 0 miRanda -0.27 0.00096 NA
67 hsa-miR-326 EFNA3 -1 0 1.06 0 MirTarget; miRanda; miRNATAP -0.13 0 NA
68 hsa-miR-326 ELFN1 -1 0 2.07 0 MirTarget; miRanda; miRNATAP -0.17 1.0E-5 NA
69 hsa-miR-326 EMILIN3 -1 0 1.78 0 miRanda; miRNATAP -0.3 1.0E-5 NA
70 hsa-miR-326 ENTPD1 -1 0 2.24 0 mirMAP -0.19 0 NA
71 hsa-miR-326 EPHB3 -1 0 3.24 0 MirTarget; PITA; miRanda; miRNATAP -0.19 0.00365 NA
72 hsa-miR-326 EPS8L1 -1 0 0.61 0 miRanda -0.18 0 NA
73 hsa-miR-326 ERBB2 -1 0 0.64 0 miRNAWalker2 validate; miRanda -0.1 0 NA
74 hsa-miR-326 ETV4 -1 0 3.76 0 miRanda -0.41 0 NA
75 hsa-miR-326 FAM109A -1 0 0.89 0 mirMAP -0.12 0 NA
76 hsa-miR-326 FAM160B2 -1 0 0.3 0 miRanda; mirMAP -0.11 0 NA
77 hsa-miR-326 FAM167B -1 0 1.09 0 miRNATAP -0.11 0.00059 NA
78 hsa-miR-326 FAM71D -1 0 0.25 0.0011 miRanda -0.12 0 NA
79 hsa-miR-326 FBXO41 -1 0 1.29 0 miRNATAP -0.11 0.00746 NA
80 hsa-miR-326 FBXO44 -1 0 0.06 0.33903 miRanda -0.11 0 NA
81 hsa-miR-326 FER1L4 -1 0 1.8 0 miRanda -0.2 0.00791 NA
82 hsa-miR-326 FHOD1 -1 0 1.38 0 miRanda; miRNATAP -0.15 0 NA
83 hsa-miR-326 FKBP8 -1 0 0.39 0 miRNATAP -0.12 0 NA
84 hsa-miR-326 FNDC4 -1 0 2.18 0 miRanda -0.12 0.0324 NA
85 hsa-miR-326 FOXI2 -1 0 2.62 0 miRNATAP -0.2 0.00742 NA
86 hsa-miR-326 FUZ -1 0 0.17 0.00708 miRNATAP -0.12 0 NA
87 hsa-miR-326 GFAP -1 0 0.63 0.00133 mirMAP -0.13 0.00825 NA
88 hsa-miR-326 GGT8P -1 0 1.43 0 miRanda -0.13 0.02193 NA
89 hsa-miR-326 GHDC -1 0 0.08 0.45184 mirMAP -0.1 6.0E-5 NA
90 hsa-miR-326 GIPC3 -1 0 1.06 0 mirMAP -0.12 0.00043 NA
91 hsa-miR-326 GJA4 -1 0 1.67 0 miRanda -0.15 7.0E-5 NA
92 hsa-miR-326 GJB3 -1 0 4.38 0 miRanda -0.31 0.00061 NA
93 hsa-miR-326 GLOD5 -1 0 0.63 6.0E-5 MirTarget; miRanda -0.11 0.00537 NA
94 hsa-miR-326 GLT1D1 -1 0 2.84 0 MirTarget -0.29 0 NA
95 hsa-miR-326 GNAS -1 0 0.15 0.18482 miRanda -0.12 2.0E-5 NA
96 hsa-miR-326 GNB3 -1 0 0.2 0.25028 miRanda -0.18 8.0E-5 NA
97 hsa-miR-326 GOLT1A -1 0 3.89 0 miRanda -0.38 0 NA
98 hsa-miR-326 GPSM1 -1 0 0.79 0 mirMAP -0.11 0 NA
99 hsa-miR-326 HMGA2 -1 0 5.95 0 miRNATAP -0.37 0.00063 NA
100 hsa-miR-326 HPCA -1 0 0.42 0.0102 miRanda -0.11 0.00743 NA
101 hsa-miR-326 HRK -1 0 2.17 0 PITA; miRanda -0.26 0.00012 NA
102 hsa-miR-326 HSD17B1 -1 0 0.31 0.00073 miRanda -0.15 0 NA
103 hsa-miR-326 HSF4 -1 0 -0.34 0.04803 miRanda -0.2 0 NA
104 hsa-miR-326 IGFBP2 -1 0 1.3 0 miRanda -0.18 0 NA
105 hsa-miR-326 IGSF1 -1 0 3.56 0 miRanda -0.36 0.00026 NA
106 hsa-miR-326 ITGA3 -1 0 1.48 0 miRanda -0.11 0.00203 NA
107 hsa-miR-326 ITGA7 -1 0 0.88 0 miRanda -0.13 0 NA
108 hsa-miR-326 ITPKA -1 0 1.67 0 MirTarget; miRanda -0.19 0.00017 NA
109 hsa-miR-326 KCNC3 -1 0 0.11 0.37068 miRanda -0.12 3.0E-5 NA
110 hsa-miR-326 KCNJ11 -1 0 0.56 6.0E-5 mirMAP -0.17 0 NA
111 hsa-miR-326 KIF22 -1 0 0.38 0 miRanda -0.13 0 NA
112 hsa-miR-326 KLHDC8A -1 0 5.36 0 miRanda -0.42 0 NA
113 hsa-miR-326 KLK5 -1 0 1.54 0.00035 MirTarget; miRanda -0.39 0.0003 NA
114 hsa-miR-326 KRBA1 -1 0 0.26 0 miRanda -0.11 0 NA
115 hsa-miR-326 KRTCAP2 -1 0 0.47 0 miRanda -0.1 0 NA
116 hsa-miR-326 LAD1 -1 0 2.31 0 miRanda -0.16 0.00058 NA
117 hsa-miR-326 LCN10 -1 0 0.36 0.12416 miRanda -0.29 0 NA
118 hsa-miR-326 LDOC1 -1 0 0.62 0 MirTarget; miRanda; miRNATAP -0.15 0 NA
119 hsa-miR-326 LRP4 -1 0 4.16 0 miRanda -0.3 1.0E-5 NA
120 hsa-miR-326 LZTS2 -1 0 0.86 0 miRanda; miRNATAP -0.15 0 NA
121 hsa-miR-326 MAPK8IP3 -1 0 0.23 0.01198 mirMAP -0.14 0 NA
122 hsa-miR-326 MDK -1 0 2.28 0 miRanda -0.13 0.01891 NA
123 hsa-miR-326 ME3 -1 0 1.14 0 miRanda -0.14 0 NA
124 hsa-miR-326 METRN -1 0 -0.14 0.3621 miRanda -0.18 0 NA
125 hsa-miR-326 MFGE8 -1 0 2 0 MirTarget; miRanda -0.15 0.00055 NA
126 hsa-miR-326 MLXIPL -1 0 1.55 0 miRanda -0.27 4.0E-5 NA
127 hsa-miR-326 MMP24 -1 0 0.12 0.16566 MirTarget; miRanda; miRNATAP -0.11 0 NA
128 hsa-miR-326 MPST -1 0 0.34 0.00011 miRanda -0.11 0 NA
129 hsa-miR-326 MRC2 -1 0 2.69 0 miRanda -0.24 0.00012 NA
130 hsa-miR-326 MSH5 -1 0 0.38 0.00037 miRanda; mirMAP -0.1 0.00013 NA
131 hsa-miR-326 MYO15B -1 0 -0.28 0.05311 miRanda -0.13 0.00027 NA
132 hsa-miR-326 NAB2 -1 0 1.79 0 mirMAP -0.18 1.0E-5 NA
133 hsa-miR-326 NARFL -1 0 0.24 5.0E-5 miRanda -0.11 0 NA
134 hsa-miR-326 NAT14 -1 0 0.41 0.00016 miRanda -0.12 2.0E-5 NA
135 hsa-miR-326 NAT8L -1 0 2.67 0 mirMAP -0.25 4.0E-5 NA
136 hsa-miR-326 NFKBIL1 -1 0 0.15 0.01604 miRanda -0.1 0 NA
137 hsa-miR-326 NINJ1 -1 0 0.9 0 MirTarget; miRanda; miRNATAP -0.15 0 NA
138 hsa-miR-326 NKX2-8 -1 0 0.58 9.0E-5 miRanda -0.12 0.00114 NA
139 hsa-miR-326 NOVA2 -1 0 0.95 0 miRNATAP -0.12 0.00026 NA
140 hsa-miR-326 NPTX2 -1 0 2.59 0 miRanda -0.17 0.00731 NA
141 hsa-miR-326 NPTXR -1 0 1.51 0 mirMAP -0.16 0 NA
142 hsa-miR-326 NRGN -1 0 0.88 0 MirTarget; miRanda; miRNATAP -0.17 0 NA
143 hsa-miR-326 P2RY11 -1 0 0.29 0.23241 mirMAP -0.17 0.00581 NA
144 hsa-miR-326 PABPC1L -1 0 0.48 0.00055 miRanda -0.2 0 NA
145 hsa-miR-326 PALM -1 0 1.55 0 MirTarget; PITA; miRanda; miRNATAP -0.21 1.0E-5 NA
146 hsa-miR-326 PAQR4 -1 0 1.63 0 miRanda -0.13 4.0E-5 NA
147 hsa-miR-326 PBX3 -1 0 0.69 3.0E-5 PITA; miRanda -0.11 0.00806 NA
148 hsa-miR-326 PCSK2 -1 0 3.07 0 miRanda -0.4 0.00022 NA
149 hsa-miR-326 PCYT2 -1 0 0.29 9.0E-5 mirMAP -0.12 0 NA
150 hsa-miR-326 PDDC1 -1 0 0.09 0.05212 mirMAP -0.1 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.05139 0.8348
2 Ras_signaling_pathway_hsa04014 6 232 0.05209 0.8348
3 ErbB_signaling_pathway_hsa04012 3 85 0.07475 0.8348
4 Apoptosis_hsa04210 4 138 0.07525 0.8348
5 Focal_adhesion_hsa04510 5 199 0.08027 0.8348
6 MAPK_signaling_pathway_hsa04010 6 295 0.1258 1
7 Calcium_signaling_pathway_hsa04020 4 182 0.1582 1
8 cAMP_signaling_pathway_hsa04024 4 198 0.1944 1
9 Rap1_signaling_pathway_hsa04015 4 206 0.2134 1
10 ECM_receptor_interaction_hsa04512 2 82 0.2431 1
11 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.4293 1
12 Autophagy_animal_hsa04140 2 128 0.4342 1
13 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.4986 1
14 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.5022 1
15 Hippo_signaling_pathway_hsa04390 2 154 0.5307 1
16 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.5614 1
17 Tight_junction_hsa04530 2 170 0.5843 1
18 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.6227 1

Quest ID: 700c4058f2ad6be540575100896c0d4e