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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7c-5p ABCB9 -1.71 0 1.01 0 MirTarget -0.27 0 NA
2 hsa-let-7c-5p ABCC10 -1.71 0 1.42 0 MirTarget -0.3 0 NA
3 hsa-let-7c-5p ANKRD49 -1.71 0 0.4 0 MirTarget -0.1 0 NA
4 hsa-let-7c-5p BZW2 -1.71 0 0.58 0 MirTarget -0.2 0 NA
5 hsa-let-7c-5p CBX5 -1.71 0 0.35 0.00158 MirTarget -0.12 3.0E-5 NA
6 hsa-let-7c-5p CBX6 -1.71 0 -0.14 0.56236 miRNAWalker2 validate -0.15 0.01207 NA
7 hsa-let-7c-5p CCNB2 -1.71 0 4.24 0 miRNAWalker2 validate -0.85 0 NA
8 hsa-let-7c-5p CCNF -1.71 0 2.17 0 miRNAWalker2 validate; MirTarget -0.5 0 NA
9 hsa-let-7c-5p CDC25A -1.71 0 1.92 0 MirTarget -0.52 0 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules
10 hsa-let-7c-5p CECR6 -1.71 0 0.39 0.03999 MirTarget -0.15 0.0024 NA
11 hsa-let-7c-5p CEP135 -1.71 0 0.28 0.03781 MirTarget -0.13 0.00011 NA
12 hsa-let-7c-5p CERCAM -1.71 0 -0.12 0.64816 MirTarget -0.14 0.03365 NA
13 hsa-let-7c-5p CNOT3 -1.71 0 0.58 0 miRNAWalker2 validate -0.14 0 NA
14 hsa-let-7c-5p COL24A1 -1.71 0 2.07 0 MirTarget -0.32 0.00072 NA
15 hsa-let-7c-5p CSNK2A1 -1.71 0 0.31 6.0E-5 miRNAWalker2 validate -0.12 0 NA
16 hsa-let-7c-5p CYB561D1 -1.71 0 1.36 0 MirTarget -0.3 0 NA
17 hsa-let-7c-5p DAGLA -1.71 0 1.16 1.0E-5 MirTarget -0.45 0 NA
18 hsa-let-7c-5p DCAF15 -1.71 0 0.44 0 MirTarget -0.1 0 NA
19 hsa-let-7c-5p DCLRE1B -1.71 0 0.72 0 MirTarget -0.11 0 NA
20 hsa-let-7c-5p DCTN5 -1.71 0 0.11 0.14575 miRNAWalker2 validate -0.14 0 NA
21 hsa-let-7c-5p DLGAP4 -1.71 0 0.62 0 MirTarget -0.18 0 NA
22 hsa-let-7c-5p DNAJC6 -1.71 0 2.32 0 miRNAWalker2 validate -0.38 0 NA
23 hsa-let-7c-5p DOT1L -1.71 0 0.59 0 miRNAWalker2 validate -0.15 0 NA
24 hsa-let-7c-5p DZIP1L -1.71 0 -0.08 0.7286 MirTarget -0.15 0.00941 NA
25 hsa-let-7c-5p E2F2 -1.71 0 2.82 0 MirTarget -0.61 0 NA
26 hsa-let-7c-5p E2F5 -1.71 0 0.73 0.0004 MirTarget -0.23 1.0E-5 NA
27 hsa-let-7c-5p ELF4 -1.71 0 -0.13 0.48973 MirTarget -0.14 0.00382 NA
28 hsa-let-7c-5p ESPL1 -1.71 0 1.88 0 MirTarget -0.45 0 NA
29 hsa-let-7c-5p FAM103A1 -1.71 0 0.49 0 miRNAWalker2 validate -0.15 0 NA
30 hsa-let-7c-5p FAM104A -1.71 0 0.38 0 MirTarget -0.1 0 NA
31 hsa-let-7c-5p FANCI -1.71 0 2.59 0 miRNAWalker2 validate -0.55 0 NA
32 hsa-let-7c-5p FIGNL2 -1.71 0 1.39 0 MirTarget -0.44 0 NA
33 hsa-let-7c-5p FKBP10 -1.71 0 0.16 0.4872 miRNAWalker2 validate -0.2 0.00073 NA
34 hsa-let-7c-5p GARS -1.71 0 0.54 0 miRNAWalker2 validate -0.16 0 NA
35 hsa-let-7c-5p GGA3 -1.71 0 0.71 0 MirTarget -0.17 0 NA
36 hsa-let-7c-5p GRPEL2 -1.71 0 0.66 0 MirTarget -0.17 0 NA
37 hsa-let-7c-5p GSK3A -1.71 0 0.35 0 miRNAWalker2 validate -0.1 0 NA
38 hsa-let-7c-5p HIF1AN -1.71 0 0.59 0 MirTarget -0.15 0 NA
39 hsa-let-7c-5p HMGA1 -1.71 0 1.53 0 MirTarget -0.52 0 NA
40 hsa-let-7c-5p HMGA2 -1.71 0 1.12 0.01594 miRNAWalker2 validate; miRTarBase; MirTarget -0.68 0 NA
41 hsa-let-7c-5p IGDCC3 -1.71 0 1.93 0 MirTarget -0.63 0 NA
42 hsa-let-7c-5p IGDCC4 -1.71 0 1.73 0 MirTarget -0.67 0 NA
43 hsa-let-7c-5p IGF2BP1 -1.71 0 5 0 MirTarget -1.64 0 NA
44 hsa-let-7c-5p IGF2BP2 -1.71 0 1.14 0.00395 MirTarget -0.67 0 NA
45 hsa-let-7c-5p IGF2BP3 -1.71 0 2.43 0 MirTarget -0.79 0 NA
46 hsa-let-7c-5p IP6K1 -1.71 0 0.89 0 miRNAWalker2 validate -0.14 0 NA
47 hsa-let-7c-5p KCTD17 -1.71 0 0.9 0.00044 MirTarget -0.48 0 NA
48 hsa-let-7c-5p KIAA1429 -1.71 0 0.53 0 MirTarget -0.12 0 NA
49 hsa-let-7c-5p KLHL31 -1.71 0 1.27 0 MirTarget -0.11 0.0191 NA
50 hsa-let-7c-5p LBR -1.71 0 0.39 0.00012 MirTarget -0.18 0 NA
51 hsa-let-7c-5p LIMD2 -1.71 0 -0.21 0.28202 MirTarget -0.22 1.0E-5 NA
52 hsa-let-7c-5p LIMK2 -1.71 0 0.89 0 MirTarget -0.24 0 NA
53 hsa-let-7c-5p LIN28B -1.71 0 2.27 5.0E-5 MirTarget -0.94 0 NA
54 hsa-let-7c-5p MDFI -1.71 0 1.61 0 MirTarget -0.45 0 NA
55 hsa-let-7c-5p MDM4 -1.71 0 0.73 0 MirTarget -0.16 0 NA
56 hsa-let-7c-5p MGAT4A -1.71 0 0.1 0.34719 MirTarget -0.14 0 NA
57 hsa-let-7c-5p NAP1L1 -1.71 0 0.49 0 MirTarget -0.25 0 NA
58 hsa-let-7c-5p NME6 -1.71 0 0.61 0 MirTarget -0.21 0 NA
59 hsa-let-7c-5p NPTX1 -1.71 0 0.93 0.00584 miRNAWalker2 validate -0.35 3.0E-5 NA
60 hsa-let-7c-5p NRARP -1.71 0 0.81 0 MirTarget -0.11 0.00649 NA
61 hsa-let-7c-5p PAG1 -1.71 0 -0.06 0.73713 MirTarget -0.11 0.02128 NA
62 hsa-let-7c-5p PAK4 -1.71 0 0.33 0.00055 miRNAWalker2 validate -0.15 0 NA
63 hsa-let-7c-5p PARD6B -1.71 0 -0.09 0.43033 MirTarget -0.14 0 NA
64 hsa-let-7c-5p PCGF3 -1.71 0 0.17 0.03987 miRNAWalker2 validate; MirTarget -0.11 0 NA
65 hsa-let-7c-5p PLAGL2 -1.71 0 0.34 0.003 MirTarget -0.17 0 NA
66 hsa-let-7c-5p PLEKHG6 -1.71 0 0.03 0.92547 MirTarget -0.2 0.00294 NA
67 hsa-let-7c-5p PLXND1 -1.71 0 0.7 0 MirTarget -0.12 6.0E-5 NA
68 hsa-let-7c-5p PRAF2 -1.71 0 0.47 4.0E-5 miRNAWalker2 validate -0.11 7.0E-5 NA
69 hsa-let-7c-5p PRKAA2 -1.71 0 0.91 0.01333 MirTarget -0.32 0.00046 NA
70 hsa-let-7c-5p PRRX1 -1.71 0 2.14 0 MirTarget -0.35 0 NA
71 hsa-let-7c-5p PTGES2 -1.71 0 0.51 0 miRNAWalker2 validate -0.15 0 NA
72 hsa-let-7c-5p PTK2 -1.71 0 0.59 0 miRNAWalker2 validate -0.11 1.0E-5 NA
73 hsa-let-7c-5p RAB11FIP4 -1.71 0 1.54 0 MirTarget -0.37 0 NA
74 hsa-let-7c-5p RAB34 -1.71 0 0.41 0.1262 miRNAWalker2 validate -0.28 2.0E-5 NA
75 hsa-let-7c-5p RAD18 -1.71 0 0.73 0 MirTarget -0.16 0 NA
76 hsa-let-7c-5p RAPGEFL1 -1.71 0 0.51 0.0061 miRNAWalker2 validate -0.1 0.02638 NA
77 hsa-let-7c-5p RFWD3 -1.71 0 0.44 0 miRNAWalker2 validate -0.13 0 NA
78 hsa-let-7c-5p RFX5 -1.71 0 1.21 0 MirTarget -0.14 0 NA
79 hsa-let-7c-5p RPL18A -1.71 0 0.3 0.01891 miRNAWalker2 validate -0.18 0 NA
80 hsa-let-7c-5p RPS13 -1.71 0 0.04 0.68892 miRNAWalker2 validate -0.1 4.0E-5 NA
81 hsa-let-7c-5p RPS24 -1.71 0 0.27 0.0468 miRNAWalker2 validate -0.2 0 NA
82 hsa-let-7c-5p SEMA3F -1.71 0 1.46 0 MirTarget -0.23 0 NA
83 hsa-let-7c-5p SEMA4F -1.71 0 1.01 6.0E-5 MirTarget -0.27 2.0E-5 NA
84 hsa-let-7c-5p SF3B4 -1.71 0 1.02 0 miRNAWalker2 validate -0.22 0 NA
85 hsa-let-7c-5p SLC10A3 -1.71 0 0.35 0.00189 miRNAWalker2 validate -0.18 0 NA
86 hsa-let-7c-5p SLC17A9 -1.71 0 0.51 0.00962 MirTarget -0.2 6.0E-5 NA
87 hsa-let-7c-5p SMARCC1 -1.71 0 0.45 0 miRNAWalker2 validate -0.13 0 NA
88 hsa-let-7c-5p SMARCD1 -1.71 0 0.64 0 miRNAWalker2 validate -0.18 0 NA
89 hsa-let-7c-5p SMCR8 -1.71 0 0.45 0 MirTarget -0.12 0 NA
90 hsa-let-7c-5p SOX13 -1.71 0 0.71 0 MirTarget -0.12 0 NA
91 hsa-let-7c-5p STX3 -1.71 0 0.27 0.06205 MirTarget -0.2 0 NA
92 hsa-let-7c-5p SUB1 -1.71 0 0.58 0 MirTarget -0.15 0 NA
93 hsa-let-7c-5p TAZ -1.71 0 0.96 0 miRNAWalker2 validate -0.16 0 NA
94 hsa-let-7c-5p TBC1D13 -1.71 0 0.86 0 MirTarget -0.17 0 NA
95 hsa-let-7c-5p TBKBP1 -1.71 0 0.92 0 MirTarget -0.26 0 NA
96 hsa-let-7c-5p TMEM165 -1.71 0 0.58 0 miRNAWalker2 validate -0.14 0 NA
97 hsa-let-7c-5p TMEM184B -1.71 0 0.89 0 miRNAWalker2 validate -0.17 0 NA
98 hsa-let-7c-5p TRIM67 -1.71 0 0.53 0.02619 MirTarget -0.22 0.00018 NA
99 hsa-let-7c-5p TRIM71 -1.71 0 1.89 0 miRNAWalker2 validate; MirTarget -0.79 0 NA
100 hsa-let-7c-5p TTLL4 -1.71 0 1.1 0 MirTarget -0.45 0 NA
101 hsa-let-7c-5p UBA52 -1.71 0 0.28 0.01101 miRNAWalker2 validate -0.11 0.00013 NA
102 hsa-let-7c-5p ZC3H3 -1.71 0 1.06 0 MirTarget -0.2 0 NA
103 hsa-let-7c-5p ZNF512B -1.71 0 0.95 0 MirTarget -0.18 0 NA
104 hsa-let-7c-5p ZNF526 -1.71 0 0.69 0 miRNAWalker2 validate -0.15 0 NA
105 hsa-let-7c-5p ZNF581 -1.71 0 1.08 0 miRNAWalker2 validate -0.32 0 NA
106 hsa-let-7c-5p ZNF710 -1.71 0 0.31 0.10337 MirTarget -0.12 0.01259 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NEGATIVE REGULATION OF CELL CYCLE PROCESS 10 214 2.077e-07 0.0009662
2 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 8 199 1.094e-05 0.009888
3 REGULATION OF CELL CYCLE 17 949 9.882e-06 0.009888
4 MITOTIC CELL CYCLE CHECKPOINT 7 139 9.249e-06 0.009888
5 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 7 146 1.275e-05 0.009888
6 CELL CYCLE CHECKPOINT 8 194 9.086e-06 0.009888
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 5 124 0.0005195 0.02701
2 Cellular_senescence_hsa04218 4 160 0.01043 0.2711
3 ABC_transporters_hsa02010 2 45 0.02376 0.4118
4 p53_signaling_pathway_hsa04115 2 68 0.05056 0.6572
5 ErbB_signaling_pathway_hsa04012 2 85 0.07482 0.7781
6 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.09863 0.8062
7 Lysosome_hsa04142 2 123 0.1386 0.8062
8 Endocytosis_hsa04144 3 244 0.1399 0.8062
9 Oocyte_meiosis_hsa04114 2 124 0.1404 0.8062
10 FoxO_signaling_pathway_hsa04068 2 132 0.155 0.8062
11 Tight_junction_hsa04530 2 170 0.2276 1
12 Focal_adhesion_hsa04510 2 199 0.2845 1
13 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.5593 1

Quest ID: 716e85258ad2752ffaa0693f87b9167e