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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200c-3p ABAT 6.47 0 0.06 0.94069 MirTarget -0.18 0.00957 NA
2 hsa-miR-200c-3p ACTC1 6.47 0 -6.26 0 MirTarget -0.55 0 NA
3 hsa-miR-200c-3p ADAMTS3 6.47 0 -3.48 0.00158 miRNATAP -0.38 6.0E-5 NA
4 hsa-miR-200c-3p ADCY2 6.47 0 -5.74 0.00019 MirTarget; miRNATAP -0.37 0.00506 NA
5 hsa-miR-200c-3p AFF3 6.47 0 -4.69 0 MirTarget; miRNATAP -0.55 0 NA
6 hsa-miR-200c-3p AMOTL2 6.47 0 -0.94 0.10811 MirTarget; miRNATAP -0.13 0.00723 NA
7 hsa-miR-200c-3p AP1S2 6.47 0 -2.97 0 MirTarget; miRNATAP -0.33 0 NA
8 hsa-miR-200c-3p ARHGAP20 6.47 0 -3.56 0.00051 MirTarget; miRNATAP -0.52 0 NA
9 hsa-miR-200c-3p ARHGAP28 6.47 0 -2.52 0.04263 MirTarget -0.36 0.0008 NA
10 hsa-miR-200c-3p ARHGAP6 6.47 0 -5.45 0 MirTarget -0.51 0 NA
11 hsa-miR-200c-3p ARHGEF17 6.47 0 -2.19 1.0E-5 miRNATAP -0.18 2.0E-5 NA
12 hsa-miR-200c-3p ARL10 6.47 0 -0.75 0.35282 mirMAP -0.23 0.00086 NA
13 hsa-miR-200c-3p ARL15 6.47 0 -0.85 0.14947 MirTarget -0.15 0.00286 NA
14 hsa-miR-200c-3p ARL2BP 6.47 0 -0.97 0.00154 miRNATAP -0.12 0 NA
15 hsa-miR-200c-3p ASAP1 6.47 0 -0.15 0.71428 MirTarget; miRNATAP -0.11 0.00254 NA
16 hsa-miR-200c-3p ATP11C 6.47 0 -0.87 0.09047 MirTarget -0.11 0.01482 NA
17 hsa-miR-200c-3p ATXN1 6.47 0 -1.43 0.00387 MirTarget; miRNATAP -0.18 2.0E-5 NA
18 hsa-miR-200c-3p BACH2 6.47 0 -2.73 0.00174 mirMAP -0.28 0.00014 NA
19 hsa-miR-200c-3p BASP1 6.47 0 -1.12 0.32909 miRNATAP -0.29 0.00304 NA
20 hsa-miR-200c-3p BCL2 6.47 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase; mirMAP -0.2 0.00073 NA
21 hsa-miR-200c-3p BNC2 6.47 0 -6.04 0 MirTarget -0.65 0 NA
22 hsa-miR-200c-3p C11orf87 6.47 0 -3.96 0.00131 miRNATAP -0.41 0.00012 NA
23 hsa-miR-200c-3p C17orf51 6.47 0 -1.61 0.06048 mirMAP -0.25 0.00075 NA
24 hsa-miR-200c-3p CACNA1C 6.47 0 -5.48 0 MirTarget -0.48 0 NA
25 hsa-miR-200c-3p CALU 6.47 0 -0.85 0.0346 MirTarget -0.11 0.00144 NA
26 hsa-miR-200c-3p CBL 6.47 0 -0.22 0.60145 MirTarget; mirMAP -0.1 0.00481 NA
27 hsa-miR-200c-3p CDK17 6.47 0 -1.12 0.0009 MirTarget; miRNATAP -0.11 0.00023 NA
28 hsa-miR-200c-3p CDK6 6.47 0 0.5 0.55124 mirMAP -0.18 0.01104 NA
29 hsa-miR-200c-3p CELF2 6.47 0 -2.48 0.00126 mirMAP; miRNATAP -0.27 4.0E-5 NA
30 hsa-miR-200c-3p CEP68 6.47 0 -1.77 1.0E-5 MirTarget -0.13 0.00021 NA
31 hsa-miR-200c-3p CFL2 6.47 0 -3.33 0 MirTarget; miRNATAP -0.21 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
32 hsa-miR-200c-3p CHD9 6.47 0 -0.3 0.4758 mirMAP; miRNATAP -0.11 0.00301 NA
33 hsa-miR-200c-3p CHN2 6.47 0 -2.38 0.00853 MirTarget -0.18 0.01746 NA
34 hsa-miR-200c-3p CHRDL1 6.47 0 -10 0 MirTarget -0.93 0 NA
35 hsa-miR-200c-3p CHST11 6.47 0 0.01 0.99092 mirMAP -0.2 0.00421 NA
36 hsa-miR-200c-3p CHST2 6.47 0 -0.56 0.58452 miRNATAP -0.2 0.02082 NA
37 hsa-miR-200c-3p CITED2 6.47 0 -2.82 0 miRNATAP -0.15 0.00238 NA
38 hsa-miR-200c-3p CLIC4 6.47 0 -2.07 1.0E-5 MirTarget; miRNATAP -0.2 0 NA
39 hsa-miR-200c-3p CLIP2 6.47 0 -1.79 0.00423 MirTarget; miRNATAP -0.18 0.00063 NA
40 hsa-miR-200c-3p CNN3 6.47 0 -1.93 6.0E-5 MirTarget; miRNATAP -0.16 6.0E-5 NA
41 hsa-miR-200c-3p CNTFR 6.47 0 -4.16 0.0243 miRNATAP -0.62 9.0E-5 NA
42 hsa-miR-200c-3p CNTN1 6.47 0 -2.85 0.12833 MirTarget; miRNATAP -0.32 0.04972 NA
43 hsa-miR-200c-3p CNTN4 6.47 0 -4.52 0.00012 miRNATAP -0.47 0 NA
44 hsa-miR-200c-3p CREB5 6.47 0 -1.55 0.13969 miRNATAP -0.23 0.01024 NA
45 hsa-miR-200c-3p CTNND2 6.47 0 -1.3 0.30842 MirTarget; miRNATAP -0.25 0.02473 NA
46 hsa-miR-200c-3p CYP1B1 6.47 0 -3.73 0.00104 miRNATAP -0.5 0 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response
47 hsa-miR-200c-3p CYTH3 6.47 0 -1.45 0.00123 MirTarget -0.14 0.00023 NA
48 hsa-miR-200c-3p DACT1 6.47 0 -3.37 0.00113 miRNATAP -0.47 0 NA
49 hsa-miR-200c-3p DDIT4L 6.47 0 -4.36 0.00321 MirTarget -0.29 0.02198 NA
50 hsa-miR-200c-3p DIXDC1 6.47 0 -4.24 0 MirTarget -0.35 0 NA
51 hsa-miR-200c-3p DLC1 6.47 0 -3.66 0 miRNATAP -0.39 0 NA
52 hsa-miR-200c-3p DMD 6.47 0 -4.18 0.00037 miRNATAP -0.28 0.0054 NA
53 hsa-miR-200c-3p DNAJB5 6.47 0 -2.37 0.00017 miRNATAP -0.26 0 NA
54 hsa-miR-200c-3p DOCK4 6.47 0 -2.11 0.00043 MirTarget -0.33 0 NA
55 hsa-miR-200c-3p DRP2 6.47 0 -1.91 0.00658 mirMAP -0.26 1.0E-5 NA
56 hsa-miR-200c-3p DTNA 6.47 0 -4.44 4.0E-5 MirTarget -0.38 5.0E-5 NA
57 hsa-miR-200c-3p DUSP1 6.47 0 -2.32 0.01163 MirTarget; miRNATAP -0.19 0.0147 NA
58 hsa-miR-200c-3p DZIP1 6.47 0 -2.74 0.00323 MirTarget -0.31 9.0E-5 NA
59 hsa-miR-200c-3p EDNRA 6.47 0 -3.86 1.0E-5 miRNAWalker2 validate; miRNATAP -0.48 0 NA
60 hsa-miR-200c-3p ENTPD1 6.47 0 -1.65 0 MirTarget; mirMAP -0.17 0 NA
61 hsa-miR-200c-3p ETS1 6.47 0 -1.33 0.02728 MirTarget; miRNATAP -0.21 4.0E-5 NA
62 hsa-miR-200c-3p ETV5 6.47 0 -1.13 0.19728 MirTarget; miRNATAP -0.15 0.03993 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration
63 hsa-miR-200c-3p F2RL2 6.47 0 -2.19 0.0286 MirTarget -0.34 6.0E-5 NA
64 hsa-miR-200c-3p FAM19A2 6.47 0 -1.96 0.02444 MirTarget -0.19 0.01302 NA
65 hsa-miR-200c-3p FAT3 6.47 0 -3.48 0.01525 MirTarget; miRNATAP -0.49 6.0E-5 NA
66 hsa-miR-200c-3p FBLN5 6.47 0 -4.86 0 miRNAWalker2 validate; miRTarBase -0.42 0 NA
67 hsa-miR-200c-3p FGF18 6.47 0 -3.02 0.02212 miRNATAP -0.26 0.02167 NA
68 hsa-miR-200c-3p FGF2 6.47 0 -4.74 0 mirMAP -0.51 0 NA
69 hsa-miR-200c-3p FHL1 6.47 0 -6.47 0 MirTarget -0.7 0 NA
70 hsa-miR-200c-3p FKBP14 6.47 0 -0.6 0.25887 mirMAP -0.16 0.00058 NA
71 hsa-miR-200c-3p FLI1 6.47 0 -2.51 0.00017 MirTarget; miRNATAP -0.29 0 NA
72 hsa-miR-200c-3p FLNA 6.47 0 -2.75 2.0E-5 miRNAWalker2 validate -0.29 0 NA
73 hsa-miR-200c-3p FLT1 6.47 0 -2.51 2.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget -0.22 1.0E-5 NA
74 hsa-miR-200c-3p FN1 6.47 0 -1.36 0.25051 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.53 0 NA
75 hsa-miR-200c-3p FOXF1 6.47 0 -3.07 9.0E-5 MirTarget -0.21 0.00153 NA
76 hsa-miR-200c-3p FOXK1 6.47 0 -0.47 0.32974 miRNATAP -0.11 0.00931 NA
77 hsa-miR-200c-3p FOXP1 6.47 0 -1.09 0.01887 mirMAP -0.11 0.00439 NA
78 hsa-miR-200c-3p FRMD6 6.47 0 -1.61 0.08207 miRNATAP -0.32 5.0E-5 NA
79 hsa-miR-200c-3p FSTL1 6.47 0 -2.21 0.00396 MirTarget -0.24 0.00032 NA
80 hsa-miR-200c-3p FYN 6.47 0 -2.7 5.0E-5 miRNATAP -0.26 0 NA
81 hsa-miR-200c-3p FZD4 6.47 0 -2.84 4.0E-5 mirMAP -0.23 8.0E-5 NA
82 hsa-miR-200c-3p GABRB3 6.47 0 -3.82 0.02528 mirMAP -0.64 1.0E-5 NA
83 hsa-miR-200c-3p GEM 6.47 0 -3.68 0 MirTarget; miRNATAP -0.33 0 NA
84 hsa-miR-200c-3p GFRA1 6.47 0 -6.72 0 mirMAP -0.92 0 NA
85 hsa-miR-200c-3p GJC1 6.47 0 -2.92 0.00079 MirTarget; miRNATAP -0.17 0.01977 NA
86 hsa-miR-200c-3p GLI3 6.47 0 -1.93 0.0645 miRNATAP -0.44 0 NA
87 hsa-miR-200c-3p GLIS2 6.47 0 -1.46 0.04526 miRNATAP -0.16 0.01016 NA
88 hsa-miR-200c-3p GPM6A 6.47 0 -8.84 0 miRNATAP -0.68 0 NA
89 hsa-miR-200c-3p GPR146 6.47 0 -3.24 0 miRNATAP -0.11 0.01728 NA
90 hsa-miR-200c-3p GPRASP2 6.47 0 -3.07 0 MirTarget -0.21 2.0E-5 NA
91 hsa-miR-200c-3p GREM1 6.47 0 -1.9 0.09368 MirTarget -0.41 2.0E-5 NA
92 hsa-miR-200c-3p HCFC2 6.47 0 -0.95 0.00435 miRNATAP -0.12 2.0E-5 NA
93 hsa-miR-200c-3p HHIP 6.47 0 -3.26 0.02749 mirMAP -0.27 0.03043 NA
94 hsa-miR-200c-3p HIVEP3 6.47 0 1.08 0.18783 miRNATAP -0.24 0.00047 NA
95 hsa-miR-200c-3p HLF 6.47 0 -4.18 0.00043 MirTarget; miRNATAP -0.34 0.00085 NA
96 hsa-miR-200c-3p IL6ST 6.47 0 -0.27 0.81784 mirMAP -0.22 0.02973 NA
97 hsa-miR-200c-3p IRS1 6.47 0 -2.43 0.00336 miRNATAP -0.33 0 NA
98 hsa-miR-200c-3p ITGA1 6.47 0 -1.26 0.08839 MirTarget -0.2 0.00124 NA
99 hsa-miR-200c-3p ITPR1 6.47 0 -3.7 0 miRNATAP -0.36 0 NA
100 hsa-miR-200c-3p ITPR2 6.47 0 -0.34 0.55073 MirTarget -0.13 0.00652 NA
101 hsa-miR-200c-3p JAG1 6.47 0 0.3 0.66716 miRNAWalker2 validate -0.23 0.00015 NA
102 hsa-miR-200c-3p JAZF1 6.47 0 -3.33 0 MirTarget; miRNATAP -0.29 0 NA
103 hsa-miR-200c-3p JUN 6.47 0 -1.4 0.02101 MirTarget -0.12 0.02177 NA
104 hsa-miR-200c-3p KANK1 6.47 0 -1.88 0.00218 MirTarget -0.21 6.0E-5 NA
105 hsa-miR-200c-3p KCND2 6.47 0 -2.76 0.00595 MirTarget; miRNATAP -0.37 1.0E-5 NA
106 hsa-miR-200c-3p KCTD15 6.47 0 -0.19 0.80405 MirTarget; miRNATAP -0.17 0.00988 NA
107 hsa-miR-200c-3p KDR 6.47 0 -3.79 0 miRNATAP -0.38 0 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
108 hsa-miR-200c-3p KIAA0040 6.47 0 -0.68 0.2064 MirTarget -0.11 0.01255 NA
109 hsa-miR-200c-3p KIAA1462 6.47 0 -4.22 0 MirTarget -0.36 0 NA
110 hsa-miR-200c-3p KIF13A 6.47 0 -0.77 0.21453 miRNATAP -0.1 0.04987 NA
111 hsa-miR-200c-3p KLF9 6.47 0 -3.7 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 2.0E-5 NA
112 hsa-miR-200c-3p KLHDC1 6.47 0 -2.41 0.00025 MirTarget -0.18 0.00125 NA
113 hsa-miR-200c-3p KLHL3 6.47 0 -2.04 0.00444 miRNATAP -0.18 0.00349 NA
114 hsa-miR-200c-3p LAMC1 6.47 0 -1.13 0.04875 MirTarget; miRNATAP -0.11 0.03256 NA
115 hsa-miR-200c-3p LATS2 6.47 0 -1.64 0.00068 miRNATAP -0.14 0.00059 NA
116 hsa-miR-200c-3p LCA5 6.47 0 -1.85 0.0069 MirTarget -0.12 0.03516 NA
117 hsa-miR-200c-3p LHFP 6.47 0 -3.72 0 MirTarget; miRNATAP -0.36 0 NA
118 hsa-miR-200c-3p LIX1L 6.47 0 -2.88 0 MirTarget -0.25 0 NA
119 hsa-miR-200c-3p MAF 6.47 0 -1.68 0.06488 miRNATAP -0.28 0.00032 NA
120 hsa-miR-200c-3p MARCH1 6.47 0 1.32 0.04357 MirTarget -0.15 0.0083 NA
121 hsa-miR-200c-3p MARCH8 6.47 0 -0.9 0.18552 MirTarget -0.16 0.00606 NA
122 hsa-miR-200c-3p MBNL2 6.47 0 -1.12 0.04591 miRNATAP -0.12 0.01377 NA
123 hsa-miR-200c-3p MEF2D 6.47 0 -1.6 0 mirMAP -0.12 1.0E-5 NA
124 hsa-miR-200c-3p MEGF10 6.47 0 -3.63 0.00058 MirTarget -0.37 4.0E-5 NA
125 hsa-miR-200c-3p MEX3B 6.47 0 -1.91 0.02006 miRNATAP -0.23 0.00103 NA
126 hsa-miR-200c-3p MFAP5 6.47 0 -6.02 0.00032 miRNATAP -0.54 0.00015 NA
127 hsa-miR-200c-3p MITF 6.47 0 -4.45 0 miRNATAP -0.3 0 NA
128 hsa-miR-200c-3p MPDZ 6.47 0 -3.48 0.00068 MirTarget -0.23 0.00827 NA
129 hsa-miR-200c-3p MPRIP 6.47 0 -1.56 6.0E-5 MirTarget; miRNATAP -0.11 0.00143 NA
130 hsa-miR-200c-3p MRVI1 6.47 0 -4.88 0 MirTarget -0.52 0 NA
131 hsa-miR-200c-3p MSN 6.47 0 -0.63 0.39017 miRNAWalker2 validate; miRTarBase; MirTarget -0.32 0 NA
132 hsa-miR-200c-3p MSRB3 6.47 0 -5.12 0 mirMAP -0.51 0 NA
133 hsa-miR-200c-3p MTSS1L 6.47 0 -0.88 0.10869 miRNATAP -0.1 0.03058 NA
134 hsa-miR-200c-3p MYO5A 6.47 0 -0.13 0.84407 mirMAP -0.21 0.00021 NA
135 hsa-miR-200c-3p NALCN 6.47 0 -2.97 0.0246 MirTarget -0.4 0.00038 NA
136 hsa-miR-200c-3p NAP1L5 6.47 0 -2.41 0.00107 MirTarget; miRNATAP -0.14 0.02804 NA
137 hsa-miR-200c-3p NCAM1 6.47 0 -7.27 0 miRTarBase -0.54 0 NA
138 hsa-miR-200c-3p NCS1 6.47 0 -1.45 0.01609 miRNATAP -0.25 0 NA
139 hsa-miR-200c-3p NDN 6.47 0 -5.07 0 MirTarget; miRNATAP -0.46 0 NA
140 hsa-miR-200c-3p NDST1 6.47 0 -0.18 0.708 miRNATAP -0.13 0.00125 NA
141 hsa-miR-200c-3p NEGR1 6.47 0 -5.45 0 miRNATAP -0.51 0 NA
142 hsa-miR-200c-3p NEK9 6.47 0 -1.02 0.00036 MirTarget -0.11 1.0E-5 NA
143 hsa-miR-200c-3p NFASC 6.47 0 -2.43 0.02593 miRNATAP -0.46 0 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer
144 hsa-miR-200c-3p NFIA 6.47 0 -0.82 0.18121 MirTarget; miRNATAP -0.12 0.01827 NA
145 hsa-miR-200c-3p NLGN4X 6.47 0 -3.16 0.05081 miRNATAP -0.48 0.00053 NA
146 hsa-miR-200c-3p NOVA1 6.47 0 -6.3 0 MirTarget; miRNATAP -0.69 0 NA
147 hsa-miR-200c-3p NR2F2 6.47 0 -3.23 2.0E-5 miRNATAP -0.18 0.00551 NA
148 hsa-miR-200c-3p NR5A2 6.47 0 -3.5 0 miRNATAP -0.29 1.0E-5 NA
149 hsa-miR-200c-3p NRIP1 6.47 0 0.2 0.71343 MirTarget; miRNATAP -0.11 0.01997 NA
150 hsa-miR-200c-3p NRIP3 6.47 0 0.14 0.8767 mirMAP -0.17 0.01974 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 66 1672 1.127e-15 5.242e-12
2 CELL DEVELOPMENT 57 1426 9.444e-14 2.197e-10
3 REGULATION OF CELLULAR COMPONENT MOVEMENT 39 771 1.25e-12 1.938e-09
4 TISSUE DEVELOPMENT 56 1518 4.217e-12 4.905e-09
5 REGULATION OF CELL DIFFERENTIATION 55 1492 7.051e-12 6.561e-09
6 CARDIOVASCULAR SYSTEM DEVELOPMENT 38 788 1.046e-11 6.955e-09
7 CIRCULATORY SYSTEM DEVELOPMENT 38 788 1.046e-11 6.955e-09
8 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 45 1142 9.495e-11 5.523e-08
9 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 42 1021 1.181e-10 6.104e-08
10 VASCULATURE DEVELOPMENT 27 469 2.826e-10 1.315e-07
11 REGULATION OF NEURON DIFFERENTIATION 29 554 5.515e-10 2.333e-07
12 NEUROGENESIS 49 1402 7.585e-10 2.941e-07
13 BLOOD VESSEL MORPHOGENESIS 23 364 1.066e-09 3.814e-07
14 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 48 1395 1.946e-09 6.467e-07
15 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 33 750 2.752e-09 8.538e-07
16 REGULATION OF CELL DEVELOPMENT 35 836 3.166e-09 9.206e-07
17 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 44 1275 9.426e-09 2.58e-06
18 EPITHELIUM DEVELOPMENT 36 945 2.139e-08 4.976e-06
19 CELLULAR COMPONENT MORPHOGENESIS 35 900 2.056e-08 4.976e-06
20 BIOLOGICAL ADHESION 38 1032 2.049e-08 4.976e-06
21 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 51 1656 2.274e-08 5.039e-06
22 HEART DEVELOPMENT 24 466 2.503e-08 5.293e-06
23 POSITIVE REGULATION OF CELL DIFFERENTIATION 33 823 2.63e-08 5.32e-06
24 RESPONSE TO WOUNDING 25 563 2.201e-07 4.096e-05
25 INTRACELLULAR SIGNAL TRANSDUCTION 47 1572 2.156e-07 4.096e-05
26 CELL JUNCTION ORGANIZATION 14 185 2.432e-07 4.353e-05
27 POSITIVE REGULATION OF CELL COMMUNICATION 46 1532 2.631e-07 4.534e-05
28 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 34 957 2.841e-07 4.722e-05
29 CENTRAL NERVOUS SYSTEM DEVELOPMENT 32 872 3.227e-07 5.178e-05
30 MESENCHYME DEVELOPMENT 14 190 3.372e-07 5.184e-05
31 REGULATION OF CELL PROLIFERATION 45 1496 3.453e-07 5.184e-05
32 LOCOMOTION 37 1114 4.245e-07 6.172e-05
33 ORGAN MORPHOGENESIS 31 841 4.553e-07 6.42e-05
34 REGULATION OF CELL ADHESION 26 629 4.93e-07 6.747e-05
35 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 15 229 5.827e-07 7.746e-05
36 REGULATION OF CELL SUBSTRATE ADHESION 13 173 7.129e-07 9.215e-05
37 EPITHELIAL CELL DIFFERENTIATION 22 495 1.192e-06 0.0001499
38 POSITIVE REGULATION OF LOCOMOTION 20 420 1.296e-06 0.0001587
39 CELL JUNCTION ASSEMBLY 11 129 1.496e-06 0.0001785
40 EMBRYO DEVELOPMENT 31 894 1.655e-06 0.0001925
41 REGULATION OF EPITHELIAL CELL PROLIFERATION 16 285 1.892e-06 0.0002147
42 POSITIVE REGULATION OF CELL DEVELOPMENT 21 472 2.066e-06 0.0002289
43 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 22 513 2.14e-06 0.0002316
44 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 138 2.907e-06 0.0003074
45 REGULATION OF NEURON PROJECTION DEVELOPMENT 19 408 3.324e-06 0.0003437
46 CELL MOTILITY 29 835 3.559e-06 0.0003523
47 LOCALIZATION OF CELL 29 835 3.559e-06 0.0003523
48 ACTIN FILAMENT BASED PROCESS 20 450 3.697e-06 0.0003584
49 HEAD DEVELOPMENT 26 709 4.478e-06 0.0004252
50 SYNAPSE ORGANIZATION 11 145 4.702e-06 0.0004376
51 SINGLE ORGANISM CELL ADHESION 20 459 4.969e-06 0.0004534
52 POSITIVE REGULATION OF RESPONSE TO STIMULUS 50 1929 5.521e-06 0.0004847
53 REGULATION OF GTPASE ACTIVITY 25 673 5.519e-06 0.0004847
54 RESPONSE TO ENDOGENOUS STIMULUS 41 1450 5.767e-06 0.000497
55 TUBE DEVELOPMENT 22 552 6.914e-06 0.000585
56 POSITIVE REGULATION OF CATALYTIC ACTIVITY 42 1518 7.455e-06 0.0006195
57 POSITIVE REGULATION OF GENE EXPRESSION 46 1733 7.629e-06 0.0006228
58 REGULATION OF CELL PROJECTION ORGANIZATION 22 558 8.194e-06 0.0006414
59 POSITIVE REGULATION OF MOLECULAR FUNCTION 47 1791 8.066e-06 0.0006414
60 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 25 689 8.271e-06 0.0006414
61 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 19 437 8.879e-06 0.0006692
62 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 29 876 8.917e-06 0.0006692
63 TUBE MORPHOGENESIS 16 323 9.326e-06 0.0006888
64 MORPHOGENESIS OF AN EPITHELIUM 18 400 9.657e-06 0.0007021
65 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 1.114e-05 0.0007977
66 ANGIOGENESIS 15 293 1.206e-05 0.0008499
67 TISSUE MORPHOGENESIS 21 533 1.336e-05 0.0009278
68 VASCULOGENESIS 7 59 1.451e-05 0.0009927
69 NEGATIVE REGULATION OF LOCOMOTION 14 263 1.526e-05 0.001025
70 CELL PROJECTION ORGANIZATION 29 902 1.542e-05 0.001025
71 EMBRYONIC MORPHOGENESIS 21 539 1.579e-05 0.001035
72 REGULATION OF EPITHELIAL CELL MIGRATION 11 166 1.705e-05 0.0011
73 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 38 1360 1.726e-05 0.0011
74 CELL SUBSTRATE JUNCTION ASSEMBLY 6 41 1.768e-05 0.001112
75 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 47 1848 1.819e-05 0.001128
76 NEURON PROJECTION DEVELOPMENT 21 545 1.861e-05 0.001139
77 REGULATION OF MEMBRANE POTENTIAL 16 343 1.96e-05 0.001184
78 POSITIVE REGULATION OF NEURON DIFFERENTIATION 15 306 2.008e-05 0.00119
79 REGULATION OF ION HOMEOSTASIS 12 201 2.021e-05 0.00119
80 REGULATION OF BODY FLUID LEVELS 20 506 2.057e-05 0.001197
81 NEGATIVE REGULATION OF CELL DEATH 28 872 2.23e-05 0.001275
82 REGULATION OF CELL MORPHOGENESIS 21 552 2.246e-05 0.001275
83 NEURON DEVELOPMENT 24 687 2.339e-05 0.001296
84 NEURON DIFFERENTIATION 28 874 2.324e-05 0.001296
85 WOUND HEALING 19 470 2.444e-05 0.001322
86 HEMOSTASIS 15 311 2.425e-05 0.001322
87 REGULATION OF ENDOTHELIAL CELL MIGRATION 9 114 2.529e-05 0.001352
88 NEPHRON DEVELOPMENT 9 115 2.712e-05 0.001434
89 REGULATION OF CELL MATRIX ADHESION 8 90 3.043e-05 0.001591
90 NEGATIVE REGULATION OF CELL COMMUNICATION 34 1192 3.314e-05 0.001713
91 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 7 67 3.373e-05 0.001724
92 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 45 1784 3.454e-05 0.001747
93 SYSTEM PROCESS 45 1785 3.501e-05 0.001752
94 REGULATION OF CHEMOTAXIS 11 180 3.613e-05 0.001788
95 ACTIN FILAMENT BASED MOVEMENT 8 93 3.86e-05 0.001871
96 NEPHRON EPITHELIUM DEVELOPMENT 8 93 3.86e-05 0.001871
97 ACTION POTENTIAL 8 94 4.17e-05 0.002
98 POSITIVE REGULATION OF HYDROLASE ACTIVITY 28 905 4.303e-05 0.002031
99 REGULATION OF CELL DEATH 39 1472 4.321e-05 0.002031
100 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 30 1008 4.631e-05 0.002155
101 POSITIVE REGULATION OF CELL PROLIFERATION 26 814 4.844e-05 0.002232
102 REGULATION OF HYDROLASE ACTIVITY 36 1327 5.428e-05 0.002428
103 RESPONSE TO ORGANIC CYCLIC COMPOUND 28 917 5.411e-05 0.002428
104 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 19 498 5.342e-05 0.002428
105 CELL PART MORPHOGENESIS 22 633 5.573e-05 0.00247
106 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 8 98 5.627e-05 0.00247
107 REGULATION OF SYSTEM PROCESS 19 507 6.776e-05 0.002947
108 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 30 1036 7.6e-05 0.003129
109 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 30 1036 7.6e-05 0.003129
110 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 9 131 7.554e-05 0.003129
111 REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 1618 7.321e-05 0.003129
112 RENAL SYSTEM PROCESS 8 102 7.485e-05 0.003129
113 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 7.44e-05 0.003129
114 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 9 133 8.494e-05 0.003426
115 BEHAVIOR 19 516 8.542e-05 0.003426
116 REGULATION OF VASCULATURE DEVELOPMENT 12 233 8.509e-05 0.003426
117 CELL CELL ADHESION 21 608 8.995e-05 0.00356
118 RENAL TUBULE DEVELOPMENT 7 78 9.028e-05 0.00356
119 MUSCLE STRUCTURE DEVELOPMENT 17 432 9.113e-05 0.003563
120 REGULATION OF TRANSPORT 44 1804 9.363e-05 0.00363
121 MORPHOGENESIS OF A BRANCHING STRUCTURE 10 167 9.671e-05 0.003719
122 REGULATION OF MAPK CASCADE 22 660 0.0001023 0.003902
123 MUSCLE ORGAN DEVELOPMENT 13 277 0.0001111 0.004204
124 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 13 278 0.0001152 0.004322
125 NEURON PROJECTION MORPHOGENESIS 16 402 0.0001286 0.004788
126 MELANOCYTE DIFFERENTIATION 4 20 0.0001346 0.004972
127 PLATELET ACTIVATION 9 142 0.0001403 0.005139
128 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 724 0.0001448 0.005224
129 TISSUE MIGRATION 7 84 0.0001445 0.005224
130 CIRCULATORY SYSTEM PROCESS 15 366 0.0001517 0.00543
131 REGULATION OF KINASE ACTIVITY 24 776 0.0001554 0.005486
132 HEART PROCESS 7 85 0.0001556 0.005486
133 PIGMENTATION 7 86 0.0001675 0.00586
134 MEMBRANE DEPOLARIZATION 6 61 0.0001741 0.006002
135 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 5 39 0.0001739 0.006002
136 CARTILAGE DEVELOPMENT 9 147 0.0001823 0.006236
137 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 43 1805 0.0001913 0.00645
138 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 62 0.0001906 0.00645
139 NEGATIVE REGULATION OF CELL PROLIFERATION 21 643 0.0001945 0.006511
140 DEVELOPMENTAL PIGMENTATION 5 40 0.0001965 0.006531
141 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 740 0.0001988 0.00656
142 PROTEIN PHOSPHORYLATION 27 944 0.0002151 0.00705
143 UROGENITAL SYSTEM DEVELOPMENT 13 299 0.0002357 0.007669
144 NEGATIVE REGULATION OF CELL ADHESION 11 223 0.0002433 0.00786
145 POSITIVE REGULATION OF MAPK CASCADE 17 470 0.000248 0.007959
146 MODULATION OF SYNAPTIC TRANSMISSION 13 301 0.0002514 0.008013
147 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 13 303 0.000268 0.008484
148 STEM CELL DIFFERENTIATION 10 190 0.0002772 0.008713
149 KIDNEY EPITHELIUM DEVELOPMENT 8 125 0.0003074 0.009598
150 REGULATION OF CELL JUNCTION ASSEMBLY 6 68 0.0003172 0.009839
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 24 629 5.471e-06 0.001992
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 36 1199 6.238e-06 0.001992
3 MOLECULAR FUNCTION REGULATOR 39 1353 6.431e-06 0.001992
4 SEQUENCE SPECIFIC DNA BINDING 32 1037 1.245e-05 0.002892
5 REGULATORY REGION NUCLEIC ACID BINDING 26 818 5.253e-05 0.008133
6 PROTEIN DOMAIN SPECIFIC BINDING 22 624 4.511e-05 0.008133
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 47 1151 9.949e-12 5.81e-09
2 CELL PROJECTION 57 1786 7.366e-10 2.151e-07
3 MEMBRANE REGION 42 1134 2.799e-09 5.449e-07
4 NEURON PROJECTION 35 942 6.334e-08 9.247e-06
5 NEURON PART 41 1265 1.784e-07 2.084e-05
6 SOMATODENDRITIC COMPARTMENT 27 650 2.665e-07 2.594e-05
7 MEMBRANE MICRODOMAIN 16 288 2.167e-06 0.0001808
8 POSTSYNAPSE 18 378 4.448e-06 0.0002634
9 SYNAPSE 27 754 4.51e-06 0.0002634
10 PLASMA MEMBRANE REGION 31 929 3.643e-06 0.0002634
11 EXCITATORY SYNAPSE 12 197 1.654e-05 0.0006899
12 CELL BODY 20 494 1.458e-05 0.0006899
13 PERIKARYON 9 108 1.638e-05 0.0006899
14 DENDRITE 19 451 1.382e-05 0.0006899
15 SYNAPSE PART 22 610 3.215e-05 0.001252
16 ACTIN FILAMENT 7 70 4.491e-05 0.001639
17 CELL CELL JUNCTION 15 383 0.0002476 0.008034
18 SYNAPTIC MEMBRANE 12 261 0.0002455 0.008034
19 SARCOLEMMA 8 125 0.0003074 0.009447

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 16 200 1.514e-08 2.726e-06
2 hsa04270_Vascular_smooth_muscle_contraction 10 116 4.083e-06 0.0003675
3 hsa04151_PI3K_AKT_signaling_pathway 17 351 6.587e-06 0.0003952
4 hsa04014_Ras_signaling_pathway 13 236 2.151e-05 0.0009679
5 hsa04720_Long.term_potentiation 7 70 4.491e-05 0.001617
6 hsa04912_GnRH_signaling_pathway 8 101 6.979e-05 0.002094
7 hsa04970_Salivary_secretion 7 89 0.0002075 0.005005
8 hsa04540_Gap_junction 7 90 0.0002225 0.005005
9 hsa04010_MAPK_signaling_pathway 12 268 0.0003124 0.00616
10 hsa04722_Neurotrophin_signaling_pathway 8 127 0.0003422 0.00616
11 hsa04971_Gastric_acid_secretion 6 74 0.0005017 0.00821
12 hsa04512_ECM.receptor_interaction 6 85 0.001047 0.0157
13 hsa04012_ErbB_signaling_pathway 6 87 0.001182 0.01636
14 hsa04666_Fc_gamma_R.mediated_phagocytosis 6 95 0.001859 0.02391
15 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 0.002462 0.02753
16 hsa04916_Melanogenesis 6 101 0.002535 0.02753
17 hsa04730_Long.term_depression 5 70 0.0026 0.02753
18 hsa04020_Calcium_signaling_pathway 8 177 0.002917 0.02917
19 hsa04070_Phosphatidylinositol_signaling_system 5 78 0.004156 0.03937
20 hsa04514_Cell_adhesion_molecules_.CAMs. 6 136 0.01065 0.09584
21 hsa04910_Insulin_signaling_pathway 6 138 0.01139 0.09761
22 hsa04972_Pancreatic_secretion 5 101 0.01215 0.0994
23 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 2 15 0.0171 0.1338
24 hsa04390_Hippo_signaling_pathway 6 154 0.01865 0.1368
25 hsa04114_Oocyte_meiosis 5 114 0.01957 0.1368
26 hsa04370_VEGF_signaling_pathway 4 76 0.01976 0.1368
27 hsa04664_Fc_epsilon_RI_signaling_pathway 4 79 0.02243 0.1496
28 hsa04810_Regulation_of_actin_cytoskeleton 7 214 0.02701 0.1736
29 hsa04380_Osteoclast_differentiation 5 128 0.03035 0.1836
30 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.03059 0.1836
31 hsa04210_Apoptosis 4 89 0.03287 0.1909
32 hsa04650_Natural_killer_cell_mediated_cytotoxicity 5 136 0.03791 0.2133
33 hsa04340_Hedgehog_signaling_pathway 3 56 0.04031 0.2198
34 hsa04310_Wnt_signaling_pathway 5 151 0.05495 0.2909
35 hsa04144_Endocytosis 6 203 0.05865 0.2925
36 hsa04660_T_cell_receptor_signaling_pathway 4 108 0.05936 0.2925
37 hsa04630_Jak.STAT_signaling_pathway 5 155 0.06013 0.2925
38 hsa04115_p53_signaling_pathway 3 69 0.06716 0.3181
39 hsa00230_Purine_metabolism 5 162 0.06985 0.3224
40 hsa04670_Leukocyte_transendothelial_migration 4 117 0.07492 0.3368
41 hsa04520_Adherens_junction 3 73 0.07672 0.3368
42 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.0817 0.3502
43 hsa04360_Axon_guidance 4 130 0.1006 0.4213
44 hsa04530_Tight_junction 4 133 0.1071 0.4381
45 hsa04062_Chemokine_signaling_pathway 5 189 0.1148 0.458
46 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.1196 0.458
47 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.1196 0.458
48 hsa04150_mTOR_signaling_pathway 2 52 0.1566 0.5871
49 hsa04976_Bile_secretion 2 71 0.2501 0.8647
50 hsa04260_Cardiac_muscle_contraction 2 77 0.2803 0.9174
51 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.4032 1
52 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.667 1
53 hsa04740_Olfactory_transduction 2 388 0.9693 1

Quest ID: 744cf4ac5c65c23b5d630d5c4fcce62f