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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7g-5p ABL2 -0.01 0.9936 0.09 0.91468 miRNATAP -0.18 0.00066 NA
2 hsa-let-7g-5p ACER2 -0.01 0.9936 0.2 0.60066 MirTarget -0.23 0.03891 NA
3 hsa-let-7g-5p ADAMTS15 -0.01 0.9936 -0.91 0.09979 MirTarget; miRNATAP -0.59 0.02862 NA
4 hsa-let-7g-5p ADAMTS5 -0.01 0.9936 0.08 0.85753 miRNATAP -0.54 0 NA
5 hsa-let-7g-5p ADAMTS8 -0.01 0.9936 -0.23 0.60879 MirTarget; miRNATAP -1.08 0 NA
6 hsa-let-7g-5p ADRB2 -0.01 0.9936 0.17 0.67129 MirTarget -0.84 0 NA
7 hsa-let-7g-5p AFF2 -0.01 0.9936 0.23 0.71237 MirTarget -0.81 4.0E-5 NA
8 hsa-let-7g-5p AKAP6 -0.01 0.9936 -0.03 0.93563 MirTarget -0.75 0 NA
9 hsa-let-7g-5p ANGPTL2 -0.01 0.9936 0.07 0.94543 miRNATAP -1.12 0 NA
10 hsa-let-7g-5p APPBP2 -0.01 0.9936 0.11 0.89785 miRNATAP -0.15 0.00011 NA
11 hsa-let-7g-5p ARHGAP20 -0.01 0.9936 0.26 0.51813 miRNATAP -1.11 0 NA
12 hsa-let-7g-5p ARHGAP28 -0.01 0.9936 0.06 0.84302 MirTarget; miRNATAP -0.56 0.00019 NA
13 hsa-let-7g-5p ARHGEF15 -0.01 0.9936 0.02 0.96438 MirTarget; miRNATAP -0.61 0 NA
14 hsa-let-7g-5p ARNT2 -0.01 0.9936 -0.28 0.615 mirMAP -0.95 0 NA
15 hsa-let-7g-5p ARRDC4 -0.01 0.9936 -0.31 0.72139 MirTarget; miRNATAP -0.3 0.0007 NA
16 hsa-let-7g-5p ASAP1 -0.01 0.9936 0.29 0.75318 miRNATAP -0.24 0.00231 NA
17 hsa-let-7g-5p ATP2B4 -0.01 0.9936 -0.01 0.98886 miRNATAP -0.81 0 NA
18 hsa-let-7g-5p ATP8B4 -0.01 0.9936 -0.24 0.34452 MirTarget -0.47 0 NA
19 hsa-let-7g-5p ATXN1 -0.01 0.9936 0.04 0.96341 miRNATAP -0.28 1.0E-5 NA
20 hsa-let-7g-5p BACH1 -0.01 0.9936 0 0.99909 MirTarget; miRNATAP -0.11 0.04668 NA
21 hsa-let-7g-5p BBX -0.01 0.9936 0.02 0.9851 miRNATAP -0.14 0.00591 NA
22 hsa-let-7g-5p BCAP29 -0.01 0.9936 0.13 0.89592 mirMAP; miRNATAP -0.13 0.00286 NA
23 hsa-let-7g-5p BEND4 -0.01 0.9936 -0.11 0.88946 miRNATAP -0.67 0.00123 NA
24 hsa-let-7g-5p BNC2 -0.01 0.9936 0.15 0.76233 miRNATAP -1.44 0 NA
25 hsa-let-7g-5p C20orf194 -0.01 0.9936 0.18 0.69037 miRNATAP -1.12 0 NA
26 hsa-let-7g-5p CACNA1E -0.01 0.9936 -0.51 0.36647 miRNATAP -1.04 0 NA
27 hsa-let-7g-5p CACNA1I -0.01 0.9936 0.28 0.67009 miRNATAP -0.61 0.00325 NA
28 hsa-let-7g-5p CACNB4 -0.01 0.9936 0.22 0.59018 miRNATAP -0.37 0.03187 NA
29 hsa-let-7g-5p CADM2 -0.01 0.9936 0.76 0.4386 MirTarget; miRNATAP -1.25 0 NA
30 hsa-let-7g-5p CALD1 -0.01 0.9936 0.13 0.92312 miRNATAP -1.2 0 NA
31 hsa-let-7g-5p CCL7 -0.01 0.9936 -0.04 0.95882 MirTarget -1.44 0 NA
32 hsa-let-7g-5p CCR7 -0.01 0.9936 -0.35 0.41294 miRNATAP -0.66 0.0006 NA
33 hsa-let-7g-5p CD200R1 -0.01 0.9936 -0.17 0.69916 miRNATAP -0.4 0.02154 NA
34 hsa-let-7g-5p CD59 -0.01 0.9936 0.05 0.96935 MirTarget -0.21 0.00036 NA
35 hsa-let-7g-5p CD86 -0.01 0.9936 -0.1 0.85291 MirTarget -0.79 0 NA
36 hsa-let-7g-5p CDKN2A -0.01 0.9936 0.37 0.40432 miRNAWalker2 validate; miRTarBase -0.54 0.00297 NA
37 hsa-let-7g-5p CERCAM -0.01 0.9936 -0.1 0.9115 MirTarget; miRNATAP -1 0 NA
38 hsa-let-7g-5p CGNL1 -0.01 0.9936 -0.08 0.89228 MirTarget; miRNATAP -0.48 0.00139 NA
39 hsa-let-7g-5p CHD3 -0.01 0.9936 -0.05 0.96644 mirMAP -0.26 0.00045 NA
40 hsa-let-7g-5p CHD9 -0.01 0.9936 -0.03 0.975 miRNATAP -0.17 0.00337 NA
41 hsa-let-7g-5p CHRD -0.01 0.9936 0.21 0.58908 MirTarget; miRNATAP -0.95 0 NA
42 hsa-let-7g-5p CHSY3 -0.01 0.9936 0.33 0.2719 miRNATAP -0.71 0 NA
43 hsa-let-7g-5p COL15A1 -0.01 0.9936 0.11 0.92071 miRNATAP -0.82 0 NA
44 hsa-let-7g-5p COL1A1 -0.01 0.9936 -0.12 0.95162 miRNATAP -1.09 0 NA
45 hsa-let-7g-5p COL1A2 -0.01 0.9936 -0.04 0.98407 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -1.16 0 NA
46 hsa-let-7g-5p COL24A1 -0.01 0.9936 0.15 0.73022 MirTarget -1.32 0 NA
47 hsa-let-7g-5p COL3A1 -0.01 0.9936 -0 0.99847 MirTarget; miRNATAP -1.24 0 NA
48 hsa-let-7g-5p COL4A1 -0.01 0.9936 0.17 0.90987 miRNATAP -0.48 0 NA
49 hsa-let-7g-5p COL4A2 -0.01 0.9936 0.08 0.95821 miRNATAP -0.58 0 NA
50 hsa-let-7g-5p COL5A2 -0.01 0.9936 0.1 0.94138 MirTarget; miRNATAP -1.02 0 NA
51 hsa-let-7g-5p CPEB1 -0.01 0.9936 0.01 0.98918 MirTarget; miRNATAP -1.77 0 NA
52 hsa-let-7g-5p CPEB4 -0.01 0.9936 0.23 0.77798 miRNATAP -0.23 0.00113 NA
53 hsa-let-7g-5p CPM -0.01 0.9936 0 0.99729 MirTarget; miRNATAP -0.38 0.00873 NA
54 hsa-let-7g-5p CREB3L2 -0.01 0.9936 -0.11 0.92546 mirMAP -0.21 0.00145 NA
55 hsa-let-7g-5p CRK -0.01 0.9936 0.02 0.97974 miRNATAP -0.15 0.01284 NA
56 hsa-let-7g-5p CRTAM -0.01 0.9936 -0.14 0.79703 MirTarget -0.61 0.00567 NA
57 hsa-let-7g-5p CYTH3 -0.01 0.9936 0.04 0.96043 miRNATAP -0.31 0 NA
58 hsa-let-7g-5p DAPK1 -0.01 0.9936 -0.26 0.74513 MirTarget -0.4 0.0273 NA
59 hsa-let-7g-5p DCN -0.01 0.9936 -0.02 0.98481 MirTarget -1.29 0 NA
60 hsa-let-7g-5p DDI2 -0.01 0.9936 -0.16 0.7107 MirTarget -0.2 0.04327 NA
61 hsa-let-7g-5p DKK3 -0.01 0.9936 0.07 0.94291 miRNATAP -0.85 0 NA
62 hsa-let-7g-5p DLC1 -0.01 0.9936 0.05 0.94293 miRNATAP -0.65 0 NA
63 hsa-let-7g-5p DMD -0.01 0.9936 0.06 0.92185 MirTarget; miRNATAP -0.66 0.00019 NA
64 hsa-let-7g-5p DST -0.01 0.9936 0.06 0.96207 miRNATAP -0.48 0 NA
65 hsa-let-7g-5p DUSP1 -0.01 0.9936 0.19 0.87119 miRNATAP -0.43 0.00122 NA
66 hsa-let-7g-5p DZIP1 -0.01 0.9936 0.2 0.6264 miRNATAP -1.07 0 NA
67 hsa-let-7g-5p DZIP1L -0.01 0.9936 -0.09 0.75447 MirTarget -0.87 0 NA
68 hsa-let-7g-5p EDN1 -0.01 0.9936 -0.48 0.53583 MirTarget; miRNATAP -0.43 0.0034 NA
69 hsa-let-7g-5p ELOVL4 -0.01 0.9936 0.22 0.53129 miRNATAP -1.02 0 NA
70 hsa-let-7g-5p ENTPD7 -0.01 0.9936 -0.19 0.80262 MirTarget -0.16 0.01205 NA
71 hsa-let-7g-5p EPHA3 -0.01 0.9936 0.22 0.58055 miRNATAP -0.9 0 NA
72 hsa-let-7g-5p EPHA4 -0.01 0.9936 -0.07 0.90219 miRNATAP -0.55 0.01056 NA
73 hsa-let-7g-5p EPHA7 -0.01 0.9936 0.16 0.77187 miRNATAP -1.63 0 NA
74 hsa-let-7g-5p ERCC4 -0.01 0.9936 -0.09 0.8756 MirTarget; miRNATAP -0.1 0.03161 NA
75 hsa-let-7g-5p ETNK2 -0.01 0.9936 0.17 0.67035 miRNATAP -0.6 0.00034 NA
76 hsa-let-7g-5p EXOC6B -0.01 0.9936 0.09 0.82349 mirMAP -0.28 0.0001 NA
77 hsa-let-7g-5p FBXO32 -0.01 0.9936 -0.15 0.82782 miRNATAP -0.69 0 NA
78 hsa-let-7g-5p FGD6 -0.01 0.9936 -0.17 0.8353 MirTarget; miRNATAP -0.27 4.0E-5 NA
79 hsa-let-7g-5p FGF11 -0.01 0.9936 -0.37 0.18829 mirMAP; miRNATAP -0.26 0.02367 NA
80 hsa-let-7g-5p FIGN -0.01 0.9936 0.07 0.90169 MirTarget -1.27 0 NA
81 hsa-let-7g-5p FIGNL2 -0.01 0.9936 0.01 0.97169 MirTarget -0.35 0.005 NA
82 hsa-let-7g-5p FMNL3 -0.01 0.9936 -0.19 0.82434 mirMAP -0.37 3.0E-5 NA
83 hsa-let-7g-5p FN1 -0.01 0.9936 0.13 0.94049 miRTarBase -1.35 0 NA
84 hsa-let-7g-5p FNDC3B -0.01 0.9936 0.11 0.92577 miRNATAP -0.16 0.01168 NA
85 hsa-let-7g-5p FOXN3 -0.01 0.9936 0.06 0.95503 miRNATAP -0.23 0.00151 NA
86 hsa-let-7g-5p FOXP2 -0.01 0.9936 0.34 0.57564 MirTarget; miRNATAP -1.59 0 NA
87 hsa-let-7g-5p FRAS1 -0.01 0.9936 0.39 0.51896 miRNATAP -0.86 0.00029 NA
88 hsa-let-7g-5p FRMD5 -0.01 0.9936 0.11 0.8114 MirTarget -0.44 0.01578 NA
89 hsa-let-7g-5p FTO -0.01 0.9936 -0 0.9974 mirMAP -0.16 0.00016 NA
90 hsa-let-7g-5p FZD4 -0.01 0.9936 0.12 0.86655 MirTarget; miRNATAP -0.45 0 NA
91 hsa-let-7g-5p GAS7 -0.01 0.9936 -0.03 0.97128 miRNATAP -1.07 0 NA
92 hsa-let-7g-5p GATM -0.01 0.9936 0.45 0.52899 MirTarget; miRNATAP -0.41 0.01544 NA
93 hsa-let-7g-5p GCNT4 -0.01 0.9936 -0.15 0.72779 MirTarget -0.82 1.0E-5 NA
94 hsa-let-7g-5p GDF6 -0.01 0.9936 0.37 0.5855 MirTarget; miRNATAP -1.51 0 NA
95 hsa-let-7g-5p GHR -0.01 0.9936 0.12 0.7645 miRNATAP -0.55 0.00375 NA
96 hsa-let-7g-5p GNAL -0.01 0.9936 0.31 0.33141 miRNATAP -0.98 0 NA
97 hsa-let-7g-5p GNS -0.01 0.9936 -0.02 0.9851 miRNATAP -0.2 0.00014 NA
98 hsa-let-7g-5p GPX7 -0.01 0.9936 0.23 0.61953 miRNATAP -0.61 0 NA
99 hsa-let-7g-5p GREB1 -0.01 0.9936 -0.03 0.91553 MirTarget; miRNATAP -0.85 0 NA
100 hsa-let-7g-5p GRIK2 -0.01 0.9936 -0.09 0.8866 miRNATAP -0.64 0.00144 NA
101 hsa-let-7g-5p HAND1 -0.01 0.9936 0.97 0.30079 MirTarget; miRNATAP -3.28 0 NA
102 hsa-let-7g-5p HAND2 -0.01 0.9936 0.4 0.48232 miRNATAP -2.38 0 NA
103 hsa-let-7g-5p HDX -0.01 0.9936 0.31 0.41591 miRNATAP -0.56 0.00138 NA
104 hsa-let-7g-5p HECTD2 -0.01 0.9936 0.14 0.67053 miRNATAP -0.52 0 NA
105 hsa-let-7g-5p HIF3A -0.01 0.9936 -0.38 0.31793 mirMAP -0.49 0.00657 NA
106 hsa-let-7g-5p HIP1 -0.01 0.9936 0.1 0.9006 MirTarget; miRNATAP -0.32 0.00023 NA
107 hsa-let-7g-5p HLF -0.01 0.9936 -0.18 0.59317 miRNATAP -0.6 3.0E-5 NA
108 hsa-let-7g-5p HOXA1 -0.01 0.9936 0.69 0.02149 miRNATAP -0.27 0.0385 NA
109 hsa-let-7g-5p IDS -0.01 0.9936 0.23 0.8424 mirMAP -0.33 0 NA
110 hsa-let-7g-5p IFI44L -0.01 0.9936 0.05 0.938 MirTarget -0.79 0.00027 NA
111 hsa-let-7g-5p IGDCC4 -0.01 0.9936 -0.14 0.72951 MirTarget; miRNATAP -0.61 0 NA
112 hsa-let-7g-5p IGF1R -0.01 0.9936 -0.02 0.98494 MirTarget; miRNATAP -0.15 0.04253 NA
113 hsa-let-7g-5p IGLON5 -0.01 0.9936 0.58 0.26908 miRNATAP -0.85 0 NA
114 hsa-let-7g-5p IKZF2 -0.01 0.9936 -0.11 0.77904 miRNATAP -0.27 0.02133 NA
115 hsa-let-7g-5p IL10 -0.01 0.9936 0.23 0.66433 miRNATAP -0.84 0 NA
116 hsa-let-7g-5p IL6R -0.01 0.9936 0.09 0.86409 miRNATAP -0.5 0.00014 NA
117 hsa-let-7g-5p ITGB3 -0.01 0.9936 0.1 0.83284 MirTarget; miRNATAP -1.07 0 NA
118 hsa-let-7g-5p KCNC3 -0.01 0.9936 0.02 0.95382 mirMAP -0.25 0.03051 NA
119 hsa-let-7g-5p KLF8 -0.01 0.9936 0.24 0.42409 miRNATAP -0.62 0 NA
120 hsa-let-7g-5p KLF9 -0.01 0.9936 0.14 0.87142 MirTarget; miRNATAP -0.49 0 NA
121 hsa-let-7g-5p KLHDC8B -0.01 0.9936 -0 0.99715 MirTarget; miRNATAP -0.46 0 NA
122 hsa-let-7g-5p KLHL6 -0.01 0.9936 -0.16 0.75546 miRNATAP -0.7 4.0E-5 NA
123 hsa-let-7g-5p KLK10 -0.01 0.9936 0.47 0.62142 MirTarget -1.04 0.00054 NA
124 hsa-let-7g-5p LBH -0.01 0.9936 0.02 0.98126 miRNATAP -0.62 0 NA
125 hsa-let-7g-5p LIMD2 -0.01 0.9936 -0.21 0.74638 MirTarget; miRNATAP -0.31 0.00264 NA
126 hsa-let-7g-5p LOXL3 -0.01 0.9936 -0.03 0.94768 miRNATAP -0.51 0 NA
127 hsa-let-7g-5p LOXL4 -0.01 0.9936 -0.04 0.9152 miRNATAP -1.16 0 NA
128 hsa-let-7g-5p LRRC17 -0.01 0.9936 0.35 0.23419 miRNATAP -0.83 0 NA
129 hsa-let-7g-5p MAP3K2 -0.01 0.9936 0 0.99741 miRNATAP -0.13 0.0132 NA
130 hsa-let-7g-5p MAP3K3 -0.01 0.9936 -0.03 0.96984 miRNATAP -0.37 0 NA
131 hsa-let-7g-5p MAP4K4 -0.01 0.9936 -0.02 0.98751 MirTarget -0.23 6.0E-5 NA
132 hsa-let-7g-5p MASP1 -0.01 0.9936 -0.18 0.76796 MirTarget; miRNATAP -2.62 0 NA
133 hsa-let-7g-5p MDFI -0.01 0.9936 0.05 0.9337 MirTarget; miRNATAP -0.38 0.00144 NA
134 hsa-let-7g-5p MDGA1 -0.01 0.9936 -0.1 0.7902 mirMAP -0.65 2.0E-5 NA
135 hsa-let-7g-5p MEF2C -0.01 0.9936 0.09 0.88777 miRNATAP -0.74 0 NA
136 hsa-let-7g-5p MEF2D -0.01 0.9936 -0.01 0.99479 miRNATAP -0.18 0.00146 NA
137 hsa-let-7g-5p MEIS2 -0.01 0.9936 -0.37 0.43604 miRNATAP -1.27 0 NA
138 hsa-let-7g-5p MIB1 -0.01 0.9936 -0.04 0.96482 MirTarget; miRNATAP -0.13 0.01927 NA
139 hsa-let-7g-5p MMP11 -0.01 0.9936 0.18 0.88245 miRNATAP -0.88 0 NA
140 hsa-let-7g-5p MRAS -0.01 0.9936 -0.02 0.96628 mirMAP -1.01 0 NA
141 hsa-let-7g-5p MYO1F -0.01 0.9936 -0.31 0.65225 miRNATAP -0.49 4.0E-5 NA
142 hsa-let-7g-5p NCOA1 -0.01 0.9936 0.02 0.98117 miRNATAP -0.11 0.02631 NA
143 hsa-let-7g-5p NEFM -0.01 0.9936 0.39 0.58952 miRNATAP -1.79 0 NA
144 hsa-let-7g-5p NOVA1 -0.01 0.9936 0.17 0.7775 miRNATAP -1.41 0 NA
145 hsa-let-7g-5p NRK -0.01 0.9936 0.29 0.61745 miRNATAP -1.63 0 NA
146 hsa-let-7g-5p NTRK3 -0.01 0.9936 0.06 0.93454 mirMAP -1.35 0 NA
147 hsa-let-7g-5p NUMBL -0.01 0.9936 -0.08 0.90329 miRNATAP -0.33 1.0E-5 NA
148 hsa-let-7g-5p OSMR -0.01 0.9936 0.05 0.93552 miRNATAP -1.19 0 NA
149 hsa-let-7g-5p PAG1 -0.01 0.9936 -0.09 0.91531 MirTarget -0.22 0.02205 NA
150 hsa-let-7g-5p PAPPA -0.01 0.9936 0.6 0.17093 MirTarget; miRNATAP -1 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 RESPONSE TO ACID CHEMICAL 22 319 1.092e-11 2.863e-08
2 CELLULAR RESPONSE TO ACID CHEMICAL 17 175 1.244e-11 2.863e-08
3 VASCULATURE DEVELOPMENT 26 469 1.846e-11 2.863e-08
4 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 50 1656 5.883e-11 6.843e-08
5 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 48 1672 8.516e-10 6.993e-07
6 CARDIOVASCULAR SYSTEM DEVELOPMENT 31 788 1.052e-09 6.993e-07
7 CIRCULATORY SYSTEM DEVELOPMENT 31 788 1.052e-09 6.993e-07
8 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 33 983 1.474e-08 8.575e-06
9 REGULATION OF MAPK CASCADE 26 660 2.561e-08 1.324e-05
10 BLOOD VESSEL MORPHOGENESIS 19 364 2.898e-08 1.349e-05
11 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 33 1021 3.649e-08 1.415e-05
12 TISSUE DEVELOPMENT 42 1518 3.456e-08 1.415e-05
13 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 14 197 4.789e-08 1.714e-05
14 POSITIVE REGULATION OF MOLECULAR FUNCTION 46 1791 6.353e-08 1.971e-05
15 REGULATION OF CELL DIFFERENTIATION 41 1492 6.265e-08 1.971e-05
16 RESPONSE TO OXYGEN CONTAINING COMPOUND 39 1381 6.827e-08 1.985e-05
17 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 28 799 8.475e-08 2.186e-05
18 MULTICELLULAR ORGANISM METABOLIC PROCESS 10 93 8.748e-08 2.186e-05
19 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 28 801 8.926e-08 2.186e-05
20 POSITIVE REGULATION OF CATALYTIC ACTIVITY 41 1518 1.003e-07 2.333e-05
21 CELLULAR RESPONSE TO AMINO ACID STIMULUS 8 53 1.213e-07 2.688e-05
22 RESPONSE TO LIPID 29 888 2.165e-07 4.579e-05
23 REGULATION OF CELL PROJECTION ORGANIZATION 22 558 3.206e-07 6.486e-05
24 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 11 135 3.451e-07 6.691e-05
25 REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 1618 5.468e-07 0.0001018
26 EMBRYONIC MORPHOGENESIS 21 539 7.302e-07 0.0001258
27 RESPONSE TO ALCOHOL 17 362 7.033e-07 0.0001258
28 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 29 957 1.003e-06 0.0001414
29 REGULATION OF DEVELOPMENTAL GROWTH 15 289 9.363e-07 0.0001414
30 POSITIVE REGULATION OF CELL COMMUNICATION 39 1532 9.713e-07 0.0001414
31 SKELETAL SYSTEM DEVELOPMENT 19 455 9.072e-07 0.0001414
32 RESPONSE TO KETONE 12 182 9.9e-07 0.0001414
33 REGULATION OF RESPONSE TO STRESS 38 1468 9.147e-07 0.0001414
34 REGULATION OF NEURON DIFFERENTIATION 21 554 1.134e-06 0.0001552
35 POSITIVE REGULATION OF RESPONSE TO STIMULUS 45 1929 1.366e-06 0.0001765
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 38 1492 1.355e-06 0.0001765
37 POSITIVE REGULATION OF MAPK CASCADE 19 470 1.468e-06 0.0001846
38 REGULATION OF JNK CASCADE 11 159 1.763e-06 0.0002159
39 REGULATION OF CELLULAR COMPONENT MOVEMENT 25 771 1.81e-06 0.000216
40 TISSUE MORPHOGENESIS 20 533 2.408e-06 0.0002719
41 LOCOMOTION 31 1114 2.454e-06 0.0002719
42 REGULATION OF CELL DEVELOPMENT 26 836 2.387e-06 0.0002719
43 EMBRYO DEVELOPMENT 27 894 2.609e-06 0.0002793
44 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 43 1848 2.641e-06 0.0002793
45 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 8 79 2.785e-06 0.0002879
46 REGULATION OF CELLULAR RESPONSE TO STRESS 23 691 3.123e-06 0.0003148
47 REGULATION OF MAP KINASE ACTIVITY 15 319 3.179e-06 0.0003148
48 COLLAGEN FIBRIL ORGANIZATION 6 38 3.681e-06 0.0003377
49 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 24 750 3.7e-06 0.0003377
50 REGULATION OF NEURON PROJECTION DEVELOPMENT 17 408 3.573e-06 0.0003377
51 TUBE MORPHOGENESIS 15 323 3.701e-06 0.0003377
52 REGULATION OF CELL PROLIFERATION 37 1496 3.779e-06 0.0003381
53 TUBE DEVELOPMENT 20 552 4.077e-06 0.000358
54 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 20 554 4.304e-06 0.0003708
55 RESPONSE TO CORTICOSTEROID 11 176 4.731e-06 0.0003776
56 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 29 1036 4.787e-06 0.0003776
57 RESPONSE TO ENDOGENOUS STIMULUS 36 1450 4.788e-06 0.0003776
58 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 29 1036 4.787e-06 0.0003776
59 RESPONSE TO AMINO ACID 9 112 4.607e-06 0.0003776
60 NEGATIVE REGULATION OF CELL DIFFERENTIATION 21 609 4.996e-06 0.0003875
61 MEMBRANE DEPOLARIZATION 7 61 5.102e-06 0.0003892
62 ANGIOGENESIS 14 293 5.671e-06 0.0004206
63 BEHAVIOR 19 516 5.695e-06 0.0004206
64 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 470 5.923e-06 0.0004306
65 REGULATION OF KINASE ACTIVITY 24 776 6.58e-06 0.000471
66 CARTILAGE MORPHOGENESIS 4 12 6.943e-06 0.0004895
67 CELL MOTILITY 25 835 7.321e-06 0.000501
68 LOCALIZATION OF CELL 25 835 7.321e-06 0.000501
69 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 28 1008 8.175e-06 0.0005513
70 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 8.63e-06 0.0005737
71 POSITIVE REGULATION OF HYDROLASE ACTIVITY 26 905 9.845e-06 0.0006452
72 ACTION POTENTIAL 8 94 1.03e-05 0.0006654
73 MORPHOGENESIS OF AN EPITHELIUM 16 400 1.159e-05 0.0007384
74 CONNECTIVE TISSUE DEVELOPMENT 11 194 1.195e-05 0.0007512
75 REGULATION OF PROTEIN MODIFICATION PROCESS 39 1710 1.339e-05 0.000831
76 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 32 1275 1.395e-05 0.0008539
77 POSITIVE REGULATION OF CELL PROLIFERATION 24 814 1.452e-05 0.0008776
78 REGULATION OF CELL MORPHOGENESIS 19 552 1.472e-05 0.0008782
79 CELLULAR RESPONSE TO LIPID 17 457 1.575e-05 0.0009279
80 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 876 1.652e-05 0.0009488
81 REGULATION OF SYSTEM PROCESS 18 507 1.651e-05 0.0009488
82 ARTERY DEVELOPMENT 7 75 2.034e-05 0.001154
83 ARTERY MORPHOGENESIS 6 51 2.128e-05 0.001193
84 RESPONSE TO RETINOIC ACID 8 107 2.664e-05 0.001476
85 TRANSMISSION OF NERVE IMPULSE 6 54 2.968e-05 0.001609
86 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 29 1142 2.973e-05 0.001609
87 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 33 1395 3.329e-05 0.00178
88 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 9 144 3.505e-05 0.001853
89 RESPONSE TO ESTRADIOL 9 146 3.907e-05 0.002042
90 CARTILAGE DEVELOPMENT 9 147 4.122e-05 0.002111
91 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 25 926 4.129e-05 0.002111
92 CENTRAL NERVOUS SYSTEM DEVELOPMENT 24 872 4.388e-05 0.002219
93 RESPONSE TO STEROID HORMONE 17 497 4.539e-05 0.002271
94 REGULATION OF SENSORY PERCEPTION 5 36 4.687e-05 0.002295
95 REGULATION OF SENSORY PERCEPTION OF PAIN 5 36 4.687e-05 0.002295
96 REGULATION OF ACTIN FILAMENT BASED PROCESS 13 312 5.131e-05 0.002487
97 EMBRYONIC ORGAN DEVELOPMENT 15 406 5.427e-05 0.002603
98 REGULATION OF TRANSFERASE ACTIVITY 25 946 5.829e-05 0.002767
99 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 28 1135 6.827e-05 0.003209
100 ORGAN MORPHOGENESIS 23 841 7.021e-05 0.003235
101 REGULATION OF GTPASE ACTIVITY 20 673 6.968e-05 0.003235
102 REGULATION OF HYDROLASE ACTIVITY 31 1327 7.463e-05 0.003404
103 POSITIVE REGULATION OF LOCOMOTION 15 420 7.938e-05 0.003586
104 REGULATION OF CELL ADHESION 19 629 8.585e-05 0.003841
105 POSITIVE REGULATION OF KINASE ACTIVITY 16 482 0.0001079 0.004761
106 MUSCLE STRUCTURE DEVELOPMENT 15 432 0.0001085 0.004761
107 SINGLE ORGANISM BEHAVIOR 14 384 0.0001108 0.004817
108 RESPONSE TO EXTERNAL STIMULUS 38 1821 0.0001191 0.00513
109 REGULATION OF MEMBRANE POTENTIAL 13 343 0.000133 0.005676
110 REGULATION OF CELL SIZE 9 172 0.0001383 0.005799
111 REGULATION OF EXTENT OF CELL GROWTH 7 101 0.000138 0.005799
112 HEAD DEVELOPMENT 20 709 0.0001407 0.005847
113 PLACENTA DEVELOPMENT 8 138 0.0001615 0.006591
114 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 12 303 0.0001605 0.006591
115 RESPONSE TO HORMONE 23 893 0.0001704 0.006894
116 POSITIVE REGULATION OF NEURON DIFFERENTIATION 12 306 0.0001758 0.006991
117 RESPONSE TO ESTROGEN 10 218 0.0001752 0.006991
118 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 11 262 0.0001817 0.007166
119 REGULATION OF CHEMOTAXIS 9 180 0.0001948 0.007616
120 NEUROGENESIS 31 1402 0.0002007 0.007782
121 IN UTERO EMBRYONIC DEVELOPMENT 12 311 0.0002041 0.00785
122 CARDIAC CHAMBER FORMATION 3 11 0.0002112 0.008057
123 REGULATION OF RESPONSE TO WOUNDING 14 413 0.0002352 0.008897
124 HEART DEVELOPMENT 15 466 0.0002467 0.009257
125 NEURONAL ACTION POTENTIAL 4 28 0.0002497 0.009293
126 RESPONSE TO NITROGEN COMPOUND 22 859 0.0002563 0.009465
NumGOOverlapSizeP ValueAdj. P Value
1 GROWTH FACTOR BINDING 14 123 1.007e-10 9.357e-08
2 PLATELET DERIVED GROWTH FACTOR BINDING 5 11 7.209e-08 3.348e-05
3 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 9 76 1.69e-07 5.232e-05
NumGOOverlapSizeP ValueAdj. P Value
1 COMPLEX OF COLLAGEN TRIMERS 7 23 4.107e-09 2.399e-06
2 EXTRACELLULAR MATRIX COMPONENT 11 125 1.576e-07 4.602e-05
3 PROTEINACEOUS EXTRACELLULAR MATRIX 17 356 5.578e-07 7.05e-05
4 ENDOPLASMIC RETICULUM LUMEN 13 201 4.332e-07 7.05e-05
5 COLLAGEN TRIMER 9 88 6.036e-07 7.05e-05
6 EXTRACELLULAR MATRIX 17 426 6.329e-06 0.0005792
7 BANDED COLLAGEN FIBRIL 4 12 6.943e-06 0.0005792
8 RECEPTOR COMPLEX 14 327 1.955e-05 0.001427

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 14 295 6.13e-06 0.0003188
2 Focal_adhesion_hsa04510 10 199 8.282e-05 0.002153
3 PI3K_Akt_signaling_pathway_hsa04151 13 352 0.0001716 0.002974
4 ECM_receptor_interaction_hsa04512 6 82 0.0003106 0.004038
5 Autophagy_animal_hsa04140 6 128 0.003153 0.03269
6 Calcium_signaling_pathway_hsa04020 7 182 0.0044 0.03269
7 Apelin_signaling_pathway_hsa04371 6 137 0.0044 0.03269
8 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.008939 0.05215
9 Jak_STAT_signaling_pathway_hsa04630 6 162 0.009748 0.05215
10 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.01003 0.05215
11 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.01108 0.05237
12 TGF_beta_signaling_pathway_hsa04350 4 84 0.0145 0.06284
13 FoxO_signaling_pathway_hsa04068 5 132 0.01628 0.06513
14 mTOR_signaling_pathway_hsa04150 5 151 0.02725 0.1012
15 Rap1_signaling_pathway_hsa04015 5 206 0.08124 0.2816
16 HIF_1_signaling_pathway_hsa04066 3 100 0.1011 0.3287
17 TNF_signaling_pathway_hsa04668 3 108 0.12 0.3543
18 Tight_junction_hsa04530 4 170 0.1227 0.3543
19 Endocytosis_hsa04144 5 244 0.1379 0.3774
20 AMPK_signaling_pathway_hsa04152 3 121 0.153 0.3978
21 Oocyte_meiosis_hsa04114 3 124 0.161 0.3987
22 Adherens_junction_hsa04520 2 72 0.1917 0.453
23 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.2027 0.4583
24 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.223 0.4743
25 ErbB_signaling_pathway_hsa04012 2 85 0.2449 0.4743
26 Hippo_signaling_pathway_hsa04390 3 154 0.2466 0.4743
27 Gap_junction_hsa04540 2 88 0.2573 0.4743
28 Ras_signaling_pathway_hsa04014 4 232 0.2601 0.4743
29 Cellular_senescence_hsa04218 3 160 0.2645 0.4743
30 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.3754 0.6174
31 cAMP_signaling_pathway_hsa04024 3 198 0.3799 0.6174
32 Lysosome_hsa04142 2 123 0.3994 0.6293
33 Necroptosis_hsa04217 2 164 0.548 0.7701

Quest ID: 74ec898f2bf67071260768ea61f00a8a