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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-148a-3p ABCA1 1.27 0 -0.71 0.00276 MirTarget; miRNATAP -0.13 0.00141 NA
2 hsa-miR-148a-3p ABLIM3 1.27 0 -1.3 0.00063 miRNATAP -0.27 8.0E-5 NA
3 hsa-miR-148a-3p ACVR1 1.27 0 -0.44 0.01143 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.11 0.00035 NA
4 hsa-miR-148a-3p ADAM19 1.27 0 -1.06 0.01895 mirMAP -0.19 0.01729 NA
5 hsa-miR-148a-3p ADAMTS15 1.27 0 -2.81 0 MirTarget; miRNATAP -0.43 5.0E-5 NA
6 hsa-miR-148a-5p ADAMTS15 1.16 0.00015 -2.81 0 mirMAP -0.33 0.0006 NA
7 hsa-miR-148a-3p ADAMTS5 1.27 0 -2.16 0 miRNATAP -0.22 0.00014 NA
8 hsa-miR-148a-5p ADAMTS5 1.16 0.00015 -2.16 0 mirMAP; miRNATAP -0.2 0.00011 NA
9 hsa-miR-148a-3p ADARB1 1.27 0 -1.93 0 miRNAWalker2 validate; mirMAP -0.31 0 NA
10 hsa-miR-148a-3p ADCY9 1.27 0 -1.5 0 mirMAP -0.2 2.0E-5 NA
11 hsa-miR-148a-3p AHDC1 1.27 0 -0.69 6.0E-5 miRNATAP -0.16 0 NA
12 hsa-miR-148a-5p ALPK3 1.16 0.00015 -1.02 0.00049 mirMAP -0.23 0 NA
13 hsa-miR-148a-3p APC 1.27 0 -0.6 0.00012 miRNAWalker2 validate -0.12 2.0E-5 NA
14 hsa-miR-148a-3p ARHGAP20 1.27 0 -3.52 0 miRNATAP -0.38 0 NA
15 hsa-miR-148a-5p ARHGAP29 1.16 0.00015 -0.34 0.31665 MirTarget -0.11 0.04655 NA
16 hsa-miR-148a-3p ARHGEF17 1.27 0 -1.19 0 miRNATAP -0.24 0 NA
17 hsa-miR-148a-5p ARID5B 1.16 0.00015 -1.57 0 mirMAP -0.13 0.00016 NA
18 hsa-miR-148a-3p ARL10 1.27 0 -1.12 0.00198 mirMAP -0.15 0.02153 NA
19 hsa-miR-148a-5p ART4 1.16 0.00015 -1.65 0.00419 mirMAP -0.27 0.00332 NA
20 hsa-miR-148a-3p ATP11A 1.27 0 0.53 0.06467 MirTarget -0.15 0.00339 NA
21 hsa-miR-148a-3p ATP1A2 1.27 0 -6.96 0 MirTarget -0.55 2.0E-5 NA
22 hsa-miR-148a-3p ATP2B4 1.27 0 -1.72 0 MirTarget; miRNATAP -0.34 0 NA
23 hsa-miR-148a-3p B4GALT5 1.27 0 -0.51 0.00437 MirTarget; miRNATAP -0.1 0.00109 NA
24 hsa-miR-148a-3p BCL2L2 1.27 0 -1.27 0 miRNATAP -0.18 0 NA
25 hsa-miR-148a-5p BCL2L2 1.16 0.00015 -1.27 0 mirMAP -0.14 0 NA
26 hsa-miR-148a-5p BDNF 1.16 0.00015 -2.91 0 mirMAP -0.14 0.04454 NA
27 hsa-miR-148a-3p BMPR2 1.27 0 -0.59 4.0E-5 mirMAP -0.12 0 NA
28 hsa-miR-148a-3p BTBD3 1.27 0 -0.6 0.00457 miRNAWalker2 validate; miRNATAP -0.12 0.00126 NA
29 hsa-miR-148a-5p C1orf21 1.16 0.00015 -1.51 0 mirMAP -0.12 0.00081 NA
30 hsa-miR-148a-5p CA12 1.16 0.00015 -0.95 0.06698 MirTarget -0.18 0.02837 NA
31 hsa-miR-148a-3p CAMK2A 1.27 0 -4.14 0 miRNATAP -0.45 1.0E-5 NA
32 hsa-miR-148a-3p CCDC85C 1.27 0 -0.47 0.02313 mirMAP -0.14 0.00024 NA
33 hsa-miR-148a-5p CD109 1.16 0.00015 -0.51 0.31559 mirMAP -0.25 0.00143 NA
34 hsa-miR-148a-5p CD44 1.16 0.00015 -0.8 0.04276 mirMAP -0.18 0.00281 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity
35 hsa-miR-148a-5p CD93 1.16 0.00015 -1.4 0 mirMAP -0.14 0.00109 NA
36 hsa-miR-148a-3p CDC42BPB 1.27 0 -0.4 0.0008 miRNATAP -0.12 0 NA
37 hsa-miR-148a-3p CFL2 1.27 0 -2.62 0 MirTarget; miRNATAP -0.31 0 NA
38 hsa-miR-148a-3p CHD5 1.27 0 -3.46 0 mirMAP -0.25 0.00227 NA
39 hsa-miR-148a-3p CHST3 1.27 0 -0.88 0.0075 mirMAP -0.24 3.0E-5 NA
40 hsa-miR-148a-5p CLIC4 1.16 0.00015 -1.72 0 mirMAP -0.19 0.00016 NA
41 hsa-miR-148a-3p CNN1 1.27 0 -5.79 0 miRNATAP -0.6 0 NA
42 hsa-miR-148a-3p COL4A1 1.27 0 0.15 0.58169 miRNATAP -0.23 0 NA
43 hsa-miR-148a-5p COL5A2 1.16 0.00015 0.19 0.64093 MirTarget -0.2 0.00173 NA
44 hsa-miR-148a-3p CPEB4 1.27 0 -1.56 0 miRNATAP -0.23 0 NA
45 hsa-miR-148a-3p CSF1 1.27 0 -1.3 0.00033 miRNATAP -0.13 0.03825 NA
46 hsa-miR-148a-3p CSPG4 1.27 0 -1.78 0 miRNATAP -0.45 0 NA
47 hsa-miR-148a-3p CYTH3 1.27 0 -0.27 0.19343 MirTarget; miRNATAP -0.15 4.0E-5 NA
48 hsa-miR-148a-3p DMPK 1.27 0 -1.53 0 MirTarget -0.23 0 NA
49 hsa-miR-148a-3p DMXL1 1.27 0 -0.95 0 MirTarget; miRNATAP -0.1 0.0003 NA
50 hsa-miR-148a-3p DNAJB4 1.27 0 -1.87 0 miRNAWalker2 validate -0.18 3.0E-5 NA
51 hsa-miR-148a-3p DNAJC18 1.27 0 -1.28 0 MirTarget -0.13 0.00025 NA
52 hsa-miR-148a-3p DTNA 1.27 0 -4.06 0 miRNATAP -0.3 0.0042 NA
53 hsa-miR-148a-5p EBF3 1.16 0.00015 -2.22 0 mirMAP -0.12 0.02809 NA
54 hsa-miR-148a-5p EDNRA 1.16 0.00015 -2.19 0 mirMAP -0.31 0 NA
55 hsa-miR-148a-3p EGR3 1.27 0 -4.25 0 MirTarget -0.22 0.00806 NA
56 hsa-miR-148a-3p ELFN2 1.27 0 -0.56 0.36612 mirMAP -0.31 0.00418 NA
57 hsa-miR-148a-3p ENTPD1 1.27 0 -1.12 0 mirMAP -0.13 7.0E-5 NA
58 hsa-miR-148a-5p ENTPD1 1.16 0.00015 -1.12 0 mirMAP -0.12 3.0E-5 NA
59 hsa-miR-148a-3p EPAS1 1.27 0 -0.53 0.02805 miRNATAP -0.16 0.00021 NA
60 hsa-miR-148a-5p EPHA3 1.16 0.00015 -3.18 0 mirMAP -0.23 0.00064 NA
61 hsa-miR-148a-3p ERRFI1 1.27 0 -1.11 0.00014 MirTarget -0.25 0 NA
62 hsa-miR-148a-3p ESYT2 1.27 0 -0.75 0 mirMAP -0.14 0 NA
63 hsa-miR-148a-3p EXOC6B 1.27 0 -0.48 0.11834 mirMAP -0.16 0.00271 NA
64 hsa-miR-148a-3p F3 1.27 0 -1.93 0.00015 MirTarget -0.28 0.00187 NA
65 hsa-miR-148a-3p FAM168B 1.27 0 -0.95 0 MirTarget -0.14 0 NA
66 hsa-miR-148a-5p FGF2 1.16 0.00015 -3.46 0 mirMAP -0.18 0.00879 NA
67 hsa-miR-148a-5p FLRT2 1.16 0.00015 -2.62 0 mirMAP -0.22 0.01293 NA
68 hsa-miR-148a-3p FOXF1 1.27 0 -3.6 0 MirTarget -0.28 6.0E-5 NA
69 hsa-miR-148a-3p FOXK1 1.27 0 -0.29 0.13213 mirMAP -0.11 0.00132 NA
70 hsa-miR-148a-5p FRMD6 1.16 0.00015 -0.93 0.00183 miRNATAP -0.12 0.01015 NA
71 hsa-miR-148a-5p FSTL1 1.16 0.00015 -1.2 3.0E-5 mirMAP -0.15 0.00126 NA
72 hsa-miR-148a-3p FYCO1 1.27 0 -1.62 0 mirMAP -0.26 0 NA
73 hsa-miR-148a-5p GALNT10 1.16 0.00015 -0.21 0.41329 mirMAP -0.14 0.00044 NA
74 hsa-miR-148a-3p GFOD1 1.27 0 -0.94 0.00661 mirMAP -0.17 0.00663 NA
75 hsa-miR-148a-5p GNAL 1.16 0.00015 -3.91 0 mirMAP -0.2 0.00873 NA
76 hsa-miR-148a-5p GNAO1 1.16 0.00015 -3.6 0 mirMAP -0.26 0.00069 NA
77 hsa-miR-148a-5p GNAQ 1.16 0.00015 -0.92 0 mirMAP -0.1 0.0002 NA
78 hsa-miR-148a-3p GOLIM4 1.27 0 -0.33 0.26739 miRNAWalker2 validate -0.14 0.01071 NA
79 hsa-miR-148a-5p GPC4 1.16 0.00015 -0.86 0.01858 mirMAP -0.14 0.013 NA
80 hsa-miR-148a-3p GPRC5A 1.27 0 -1.04 0.01909 MirTarget -0.27 0.00059 NA
81 hsa-miR-148a-3p GRIK3 1.27 0 -4.42 0 mirMAP -0.28 0.00526 NA
82 hsa-miR-148a-3p HIPK3 1.27 0 -1.75 0 MirTarget -0.22 0.00095 NA
83 hsa-miR-148a-5p IFFO2 1.16 0.00015 -0.91 0.00201 mirMAP -0.11 0.01677 NA
84 hsa-miR-148a-5p IGF1 1.16 0.00015 -3.76 0 mirMAP -0.21 0.0237 NA
85 hsa-miR-148a-5p IGF1R 1.16 0.00015 -0.49 0.0461 mirMAP -0.15 6.0E-5 NA
86 hsa-miR-148a-3p IGF2 1.27 0 0.1 0.91238 mirMAP -0.41 0.00835 NA
87 hsa-miR-148a-3p IL6ST 1.27 0 -2.1 2.0E-5 MirTarget; miRNATAP -0.3 0.00066 NA
88 hsa-miR-148a-3p IRS1 1.27 0 -0.85 0.00822 miRNAWalker2 validate; miRTarBase -0.13 0.01963 NA
89 hsa-miR-148a-3p ITGA5 1.27 0 -2.13 0 miRNATAP -0.34 0 NA
90 hsa-miR-148a-3p ITGB8 1.27 0 -0.77 0.0782 miRNATAP -0.17 0.03204 NA
91 hsa-miR-148a-3p ITPK1 1.27 0 -0.61 0.00024 MirTarget; miRNATAP -0.16 0 NA
92 hsa-miR-148a-5p JAM2 1.16 0.00015 -3.24 0 miRNATAP -0.13 0.04182 NA
93 hsa-miR-148a-5p KATNAL1 1.16 0.00015 -1.58 1.0E-5 mirMAP -0.14 0.01206 NA
94 hsa-miR-148a-3p KCND3 1.27 0 -4.09 0 miRNATAP -0.36 0.0007 NA
95 hsa-miR-148a-5p KCND3 1.16 0.00015 -4.09 0 mirMAP -0.24 0.01003 NA
96 hsa-miR-148a-3p KCNQ5 1.27 0 -3.67 0 miRNATAP -0.26 0.0268 NA
97 hsa-miR-148a-3p KIAA0232 1.27 0 -1.01 0 MirTarget; miRNATAP -0.14 0 NA
98 hsa-miR-148a-3p KIAA0513 1.27 0 -1.87 0 mirMAP -0.19 0.00013 NA
99 hsa-miR-148a-5p KIAA1462 1.16 0.00015 -1.72 0 mirMAP -0.26 0 NA
100 hsa-miR-148a-5p KIAA1614 1.16 0.00015 -2.01 0 mirMAP -0.12 0.00652 NA
101 hsa-miR-148a-3p KIAA1644 1.27 0 -4.4 0 mirMAP -0.47 0 NA
102 hsa-miR-148a-3p KIF1B 1.27 0 -0.68 2.0E-5 mirMAP -0.15 0 NA
103 hsa-miR-148a-5p KIFC3 1.16 0.00015 0.28 0.29292 MirTarget -0.23 0 NA
104 hsa-miR-148a-5p KIRREL 1.16 0.00015 -1.37 0.00482 mirMAP -0.22 0.00367 NA
105 hsa-miR-148a-3p KLF4 1.27 0 -2.67 0 MirTarget; miRNATAP -0.15 0.01423 NA
106 hsa-miR-148a-5p KLF9 1.16 0.00015 -2.79 0 mirMAP -0.14 0.00558 NA
107 hsa-miR-148a-5p KLHL4 1.16 0.00015 -2.04 0.0002 mirMAP -0.36 3.0E-5 NA
108 hsa-miR-148a-3p LCOR 1.27 0 -0.36 0.27591 miRNATAP -0.12 0.03394 NA
109 hsa-miR-148a-3p LDLR 1.27 0 -1.42 7.0E-5 miRNATAP -0.17 0.00709 NA
110 hsa-miR-148a-5p LEFTY2 1.16 0.00015 -2.33 0.00054 MirTarget -0.32 0.00295 NA
111 hsa-miR-148a-5p LMO1 1.16 0.00015 -2.22 2.0E-5 MirTarget -0.23 0.00536 NA
112 hsa-miR-148a-3p LONRF2 1.27 0 -3.86 0 mirMAP -0.3 0.02183 NA
113 hsa-miR-148a-5p LPCAT2 1.16 0.00015 -0.31 0.31845 MirTarget -0.13 0.00542 NA
114 hsa-miR-148a-5p LPL 1.16 0.00015 -0.98 0.02055 mirMAP -0.14 0.03533 NA
115 hsa-miR-148a-5p LSM11 1.16 0.00015 -0.97 0 mirMAP -0.17 0 NA
116 hsa-miR-148a-3p LTBP1 1.27 0 -1.1 0.00013 MirTarget; miRNATAP -0.12 0.01743 NA
117 hsa-miR-148a-5p LTBP2 1.16 0.00015 -0.17 0.61169 mirMAP -0.22 5.0E-5 NA
118 hsa-miR-148a-3p LYNX1 1.27 0 -2.28 0 mirMAP -0.4 0 NA
119 hsa-miR-148a-5p MAP1B 1.16 0.00015 -3.18 0 mirMAP; miRNATAP -0.3 0 NA
120 hsa-miR-148a-5p MAPRE2 1.16 0.00015 -1.49 0 mirMAP -0.12 0.00325 NA
121 hsa-miR-148a-3p MARCH3 1.27 0 -0.64 0.02308 MirTarget; miRNATAP -0.16 0.00191 NA
122 hsa-miR-148a-3p MITF 1.27 0 -2.11 0 miRNATAP -0.2 0.00143 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells
123 hsa-miR-148a-5p MRC1 1.16 0.00015 -1.55 0.0017 MirTarget -0.16 0.03794 NA
124 hsa-miR-148a-5p MSRB3 1.16 0.00015 -3.32 0 mirMAP -0.37 0 NA
125 hsa-miR-148a-3p MTMR9 1.27 0 -0.84 0 miRNAWalker2 validate; MirTarget -0.14 0 NA
126 hsa-miR-148a-3p MTSS1L 1.27 0 -0.35 0.10973 MirTarget; miRNATAP -0.2 0 NA
127 hsa-miR-148a-3p MXRA7 1.27 0 -1.86 0 mirMAP -0.29 0 NA
128 hsa-miR-148a-3p MYO5A 1.27 0 -0.27 0.31162 mirMAP -0.11 0.02373 NA
129 hsa-miR-148a-3p NCAM1 1.27 0 -5.47 0 miRNATAP -0.51 1.0E-5 NA
130 hsa-miR-148a-3p NDST1 1.27 0 -0.25 0.17674 mirMAP; miRNATAP -0.1 0.0017 NA
131 hsa-miR-148a-5p NEURL1B 1.16 0.00015 -1.41 0 mirMAP -0.11 0.01473 NA
132 hsa-miR-148a-3p NFAT5 1.27 0 -0.39 0.03775 miRNATAP -0.1 0.00224 NA
133 hsa-miR-148a-3p NOL4 1.27 0 -3.94 0 miRNATAP -0.36 0.00063 NA
134 hsa-miR-148a-3p NOVA1 1.27 0 -4.22 0 miRNATAP -0.37 0.0001 NA
135 hsa-miR-148a-5p NOVA1 1.16 0.00015 -4.22 0 miRNATAP -0.26 0.00272 NA
136 hsa-miR-148a-3p NPTN 1.27 0 -0.74 0 MirTarget; miRNATAP -0.13 0 NA
137 hsa-miR-148a-3p NPTX1 1.27 0 -3.05 0 miRNATAP -0.34 0.00028 NA
138 hsa-miR-148a-3p NRP1 1.27 0 -0.61 0.02915 miRNATAP -0.15 0.00242 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner
139 hsa-miR-148a-5p NT5E 1.16 0.00015 -1.32 0.00558 miRNATAP -0.41 0 NA
140 hsa-miR-148a-3p PCDH10 1.27 0 -3.24 0 miRNATAP -0.35 0.0026 NA
141 hsa-miR-148a-5p PDE4D 1.16 0.00015 -2.17 0 mirMAP -0.14 0.00077 NA
142 hsa-miR-148a-3p PDE5A 1.27 0 -2.72 0 MirTarget -0.24 2.0E-5 NA
143 hsa-miR-148a-5p PDE5A 1.16 0.00015 -2.72 0 mirMAP -0.14 0.00598 NA
144 hsa-miR-148a-5p PDLIM5 1.16 0.00015 -0.94 0 mirMAP; miRNATAP -0.19 0 NA
145 hsa-miR-148a-3p PITPNM2 1.27 0 -1.17 0 MirTarget -0.25 0 NA
146 hsa-miR-148a-3p PITPNM3 1.27 0 -1.79 3.0E-5 mirMAP -0.22 0.00363 NA
147 hsa-miR-148a-3p PLXDC1 1.27 0 0 0.99489 mirMAP -0.12 0.01104 NA
148 hsa-miR-148a-5p PLXNA2 1.16 0.00015 -0.88 0.00059 MirTarget; miRNATAP -0.18 1.0E-5 NA
149 hsa-miR-148a-3p PPARGC1B 1.27 0 -1.48 0 miRNATAP -0.15 0.00394 NA
150 hsa-miR-148a-3p PPFIA2 1.27 0 -2.56 0 miRNATAP -0.2 0.02504 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CARDIOVASCULAR SYSTEM DEVELOPMENT 33 788 8.136e-11 1.893e-07
2 CIRCULATORY SYSTEM DEVELOPMENT 33 788 8.136e-11 1.893e-07
3 VASCULATURE DEVELOPMENT 25 469 1.421e-10 2.204e-07
4 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 37 1008 2.172e-10 2.527e-07
5 RESPONSE TO ENDOGENOUS STIMULUS 45 1450 4.367e-10 4.064e-07
6 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 51 1848 1.43e-09 9.59e-07
7 REGULATION OF PHOSPHORUS METABOLIC PROCESS 47 1618 1.443e-09 9.59e-07
8 REGULATION OF CELLULAR COMPONENT MOVEMENT 30 771 3.573e-09 2.078e-06
9 REGULATION OF MUSCLE SYSTEM PROCESS 15 195 6.433e-09 3.326e-06
10 REGULATION OF CELL DIFFERENTIATION 43 1492 1.055e-08 4.908e-06
11 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 27 689 2.005e-08 8.481e-06
12 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 29 799 3.077e-08 1.142e-05
13 BLOOD VESSEL MORPHOGENESIS 19 364 3.594e-08 1.142e-05
14 RESPONSE TO OXYGEN CONTAINING COMPOUND 40 1381 3.309e-08 1.142e-05
15 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 38 1275 3.681e-08 1.142e-05
16 ANGIOGENESIS 17 293 4.222e-08 1.228e-05
17 REGULATION OF PROTEIN MODIFICATION PROCESS 45 1710 6.799e-08 1.861e-05
18 LOCOMOTION 34 1114 1.221e-07 3.157e-05
19 REGULATION OF CELL ADHESION 24 629 2.118e-07 5.186e-05
20 GROWTH 19 410 2.303e-07 5.358e-05
21 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 43 1672 2.673e-07 5.654e-05
22 DEVELOPMENTAL GROWTH 17 333 2.645e-07 5.654e-05
23 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 2.908e-07 5.883e-05
24 TUBE DEVELOPMENT 22 552 3.364e-07 6.032e-05
25 CELLULAR RESPONSE TO NITROGEN COMPOUND 21 505 3.159e-07 6.032e-05
26 REGULATION OF SYSTEM PROCESS 21 507 3.371e-07 6.032e-05
27 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 42 1656 5.486e-07 9.455e-05
28 CELL DEVELOPMENT 38 1426 6.328e-07 0.0001052
29 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 541 9.647e-07 0.0001496
30 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 21 541 9.647e-07 0.0001496
31 NEURON PROJECTION DEVELOPMENT 21 545 1.085e-06 0.0001591
32 TISSUE DEVELOPMENT 39 1518 1.094e-06 0.0001591
33 RESPONSE TO NITROGEN COMPOUND 27 859 1.595e-06 0.0002121
34 HEART DEVELOPMENT 19 466 1.581e-06 0.0002121
35 NEGATIVE REGULATION OF PHOSPHORYLATION 18 422 1.593e-06 0.0002121
36 HEAD DEVELOPMENT 24 709 1.782e-06 0.0002303
37 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 30 1036 2.156e-06 0.0002447
38 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 30 1036 2.156e-06 0.0002447
39 CENTRAL NERVOUS SYSTEM DEVELOPMENT 27 872 2.117e-06 0.0002447
40 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 22 616 2.079e-06 0.0002447
41 EXTRACELLULAR STRUCTURE ORGANIZATION 15 304 2.077e-06 0.0002447
42 NEURON DIFFERENTIATION 27 874 2.21e-06 0.0002449
43 REGULATION OF KINASE ACTIVITY 25 776 2.591e-06 0.0002804
44 TISSUE MORPHOGENESIS 20 533 2.957e-06 0.0003128
45 NEUROGENESIS 36 1402 3.067e-06 0.0003171
46 MORPHOGENESIS OF AN EPITHELIUM 17 400 3.286e-06 0.0003253
47 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 3.24e-06 0.0003253
48 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 28 957 4.002e-06 0.000388
49 CARDIAC MUSCLE TISSUE DEVELOPMENT 10 140 4.435e-06 0.0004127
50 TUBE MORPHOGENESIS 15 323 4.359e-06 0.0004127
51 NEGATIVE REGULATION OF CELL COMMUNICATION 32 1192 4.705e-06 0.0004293
52 REGULATION OF EPITHELIAL CELL PROLIFERATION 14 285 4.816e-06 0.0004298
53 TISSUE MIGRATION 8 84 4.895e-06 0.0004298
54 REGULATION OF MUSCLE CONTRACTION 10 147 6.854e-06 0.0005906
55 RESPONSE TO GROWTH FACTOR 18 475 8.236e-06 0.0006968
56 EPITHELIUM DEVELOPMENT 27 945 9.285e-06 0.0007449
57 CELL MOTILITY 25 835 9.26e-06 0.0007449
58 LOCALIZATION OF CELL 25 835 9.26e-06 0.0007449
59 POSITIVE REGULATION OF MOLECULAR FUNCTION 41 1791 9.868e-06 0.0007782
60 NEURON DEVELOPMENT 22 687 1.176e-05 0.0009065
61 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 41 1805 1.188e-05 0.0009065
62 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 18 498 1.558e-05 0.001169
63 POSITIVE REGULATION OF CATALYTIC ACTIVITY 36 1518 1.776e-05 0.001312
64 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 4 15 1.965e-05 0.001429
65 MUSCLE SYSTEM PROCESS 13 282 2.07e-05 0.001459
66 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 15 368 2.053e-05 0.001459
67 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 513 2.31e-05 0.001597
68 CELL GROWTH 9 135 2.335e-05 0.001597
69 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 8 104 2.384e-05 0.001608
70 POSITIVE REGULATION OF LOCOMOTION 16 420 2.485e-05 0.001652
71 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 4 16 2.597e-05 0.001702
72 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 33 1360 2.645e-05 0.001709
73 PATTERNING OF BLOOD VESSELS 5 32 2.768e-05 0.001764
74 NEGATIVE REGULATION OF KINASE ACTIVITY 12 250 2.909e-05 0.001829
75 ORGAN MORPHOGENESIS 24 841 3.07e-05 0.001905
76 REGULATION OF CALCINEURIN NFAT SIGNALING CASCADE 4 17 3.366e-05 0.002061
77 MUSCLE STRUCTURE DEVELOPMENT 16 432 3.49e-05 0.002109
78 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 29 1142 3.816e-05 0.002276
79 REGULATION OF HYDROLASE ACTIVITY 32 1327 4.005e-05 0.002359
80 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 28 1087 4.091e-05 0.002379
81 ENDOTHELIAL CELL MIGRATION 6 57 4.37e-05 0.00251
82 REGULATION OF HEART CONTRACTION 11 221 4.512e-05 0.00256
83 POSITIVE REGULATION OF OSSIFICATION 7 84 4.642e-05 0.002602
84 REGULATION OF RECEPTOR ACTIVITY 8 117 5.567e-05 0.003084
85 NEURON PROJECTION MORPHOGENESIS 15 402 5.652e-05 0.003094
86 REGULATION OF MUSCLE HYPERTROPHY 5 37 5.721e-05 0.003096
87 FOREBRAIN DEVELOPMENT 14 357 5.897e-05 0.003154
88 SKELETAL SYSTEM DEVELOPMENT 16 455 6.458e-05 0.003412
89 AMEBOIDAL TYPE CELL MIGRATION 9 154 6.569e-05 0.003412
90 RELAXATION OF MUSCLE 4 20 6.673e-05 0.003412
91 POSITIVE REGULATION OF CHEMOTAXIS 8 120 6.664e-05 0.003412
92 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 23 829 6.947e-05 0.003514
93 REGULATION OF TRANSFERASE ACTIVITY 25 946 7.254e-05 0.003584
94 ENDOTHELIUM DEVELOPMENT 7 90 7.231e-05 0.003584
95 REGULATION OF CELL PROLIFERATION 34 1496 7.318e-05 0.003584
96 CONNECTIVE TISSUE DEVELOPMENT 10 194 7.487e-05 0.003629
97 REGULATION OF MUSCLE ADAPTATION 6 63 7.734e-05 0.00371
98 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 28 1135 8.64e-05 0.004102
99 REGULATION OF CARDIAC CONDUCTION 6 66 0.0001005 0.004726
100 SYNAPTIC SIGNALING 15 424 0.0001024 0.004766
101 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 6 68 0.0001189 0.005476
102 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 0.0001241 0.005659
103 REGULATION OF AXONOGENESIS 9 168 0.000128 0.005771
104 POSITIVE REGULATION OF AXONOGENESIS 6 69 0.000129 0.005771
105 SECRETION BY CELL 16 486 0.0001386 0.006141
106 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 4 24 0.0001412 0.006164
107 REGULATION OF BLOOD CIRCULATION 12 295 0.0001417 0.006164
108 CHEMICAL HOMEOSTASIS 23 874 0.000152 0.00655
109 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 33 1492 0.0001575 0.006724
110 ENDOTHELIAL CELL DIFFERENTIATION 6 72 0.0001634 0.006913
111 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 4 25 0.0001667 0.006987
112 RESPONSE TO ALKALOID 8 137 0.0001683 0.006991
113 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 0.0001706 0.007025
114 CELLULAR RESPONSE TO ACID CHEMICAL 9 175 0.0001743 0.007112
115 REGULATION OF MAPK CASCADE 19 660 0.0001902 0.007696
116 NEUROMUSCULAR SYNAPTIC TRANSMISSION 4 26 0.0001952 0.007831
117 REGULATION OF OSSIFICATION 9 178 0.0001979 0.007872
118 ARTERY DEVELOPMENT 6 75 0.0002048 0.008008
119 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 6 75 0.0002048 0.008008
120 REGULATION OF SEQUESTERING OF CALCIUM ION 7 107 0.0002146 0.008074
121 EMBRYO DEVELOPMENT 23 894 0.0002109 0.008074
122 REGULATION OF CHEMOTAXIS 9 180 0.0002152 0.008074
123 PLATELET DEGRANULATION 7 107 0.0002146 0.008074
124 REGULATION OF CELL DEVELOPMENT 22 836 0.0002125 0.008074
125 REGULATION OF CALCIUM MEDIATED SIGNALING 6 76 0.0002203 0.008157
126 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 1784 0.0002209 0.008157
127 NEGATIVE REGULATION OF MOLECULAR FUNCTION 26 1079 0.0002272 0.0082
128 EXOCYTOSIS 12 310 0.0002242 0.0082
129 MUCOPOLYSACCHARIDE METABOLIC PROCESS 7 108 0.0002273 0.0082
130 RESPONSE TO WOUNDING 17 563 0.0002395 0.008322
131 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 31 1395 0.000234 0.008322
132 REGULATION OF NEURON PROJECTION DEVELOPMENT 14 408 0.0002383 0.008322
133 DEVELOPMENTAL CELL GROWTH 6 77 0.0002367 0.008322
134 CELL PROJECTION ORGANIZATION 23 902 0.0002397 0.008322
135 POSITIVE REGULATION OF GENE EXPRESSION 36 1733 0.0002635 0.009014
136 REGULATION OF SPROUTING ANGIOGENESIS 4 28 0.0002627 0.009014
137 CARTILAGE DEVELOPMENT 8 147 0.0002724 0.009055
138 REGULATION OF STRIATED MUSCLE CONTRACTION 6 79 0.0002723 0.009055
139 CELL FATE COMMITMENT 10 227 0.0002702 0.009055
140 REGULATION OF CELL DEATH 32 1472 0.0002724 0.009055
141 CELLULAR RESPONSE TO EPINEPHRINE STIMULUS 3 12 0.0002905 0.009587
142 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 5 52 0.0002973 0.009742
143 REGULATION OF THE FORCE OF HEART CONTRACTION 4 29 0.000302 0.009828
144 MUSCLE TISSUE DEVELOPMENT 11 275 0.0003092 0.009991
NumGOOverlapSizeP ValueAdj. P Value
1 MOLECULAR FUNCTION REGULATOR 35 1353 3.644e-06 0.003385
2 GROWTH FACTOR BINDING 9 123 1.105e-05 0.005132
3 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 7 81 3.667e-05 0.007988
4 PROTEIN COMPLEX BINDING 25 935 6.019e-05 0.007988
5 ENZYME REGULATOR ACTIVITY 26 959 3.368e-05 0.007988
6 ENZYME BINDING 38 1737 5.914e-05 0.007988
7 PHOSPHATASE REGULATOR ACTIVITY 7 87 5.819e-05 0.007988
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 34 942 1.987e-09 1.16e-06
2 NEURON PART 39 1265 9.416e-09 2.749e-06
3 SOMATODENDRITIC COMPARTMENT 26 650 2.484e-08 4.835e-06
4 DENDRITE 20 451 2.216e-07 3.235e-05
5 EXTRACELLULAR MATRIX 19 426 4.131e-07 4.825e-05
6 CELL JUNCTION 33 1151 7.847e-07 7.638e-05
7 CELL PROJECTION 43 1786 1.566e-06 0.0001307
8 SYNAPSE 24 754 5.108e-06 0.0003544
9 CELL SURFACE 24 757 5.462e-06 0.0003544
10 CELL CELL JUNCTION 15 383 3.258e-05 0.001903
11 PROTEINACEOUS EXTRACELLULAR MATRIX 14 356 5.722e-05 0.003038
12 SARCOLEMMA 8 125 8.889e-05 0.004326
13 PLATELET ALPHA GRANULE 6 75 0.0002048 0.007011
14 INTRINSIC COMPONENT OF PLASMA MEMBRANE 35 1649 0.0002161 0.007011
15 EXTRACELLULAR SPACE 31 1376 0.0001839 0.007011
16 CELL BODY 16 494 0.0001669 0.007011
17 MEMBRANE REGION 27 1134 0.0002073 0.007011
18 SYNAPSE PART 18 610 0.0002083 0.007011

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 11 163 2.56e-06 0.0001081
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 10 139 4.159e-06 0.0001081
3 FoxO_signaling_pathway_hsa04068 9 132 1.951e-05 0.0003382
4 cAMP_signaling_pathway_hsa04024 9 198 0.0004342 0.005645
5 PI3K_Akt_signaling_pathway_hsa04151 12 352 0.0006992 0.007272
6 Apelin_signaling_pathway_hsa04371 7 137 0.0009523 0.008254
7 Calcium_signaling_pathway_hsa04020 8 182 0.001117 0.008295
8 Hippo_signaling_pathway_hsa04390 7 154 0.001871 0.01135
9 Focal_adhesion_hsa04510 8 199 0.001965 0.01135
10 AMPK_signaling_pathway_hsa04152 6 121 0.002546 0.01247
11 TGF_beta_signaling_pathway_hsa04350 5 84 0.002638 0.01247
12 MAPK_signaling_pathway_hsa04010 9 295 0.006558 0.02775
13 p53_signaling_pathway_hsa04115 4 68 0.007353 0.02775
14 mTOR_signaling_pathway_hsa04150 6 151 0.007471 0.02775
15 Rap1_signaling_pathway_hsa04015 7 206 0.009111 0.03113
16 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.009578 0.03113
17 Oocyte_meiosis_hsa04114 5 124 0.01341 0.04039
18 ECM_receptor_interaction_hsa04512 4 82 0.01398 0.04039
19 Autophagy_animal_hsa04140 5 128 0.0152 0.04161
20 Wnt_signaling_pathway_hsa04310 5 146 0.02524 0.06563
21 HIF_1_signaling_pathway_hsa04066 4 100 0.02683 0.06644
22 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.04226 0.09989
23 Sphingolipid_signaling_pathway_hsa04071 4 118 0.045 0.1017
24 Ras_signaling_pathway_hsa04014 6 232 0.0486 0.1053
25 Gap_junction_hsa04540 3 88 0.07782 0.1619
26 Cellular_senescence_hsa04218 4 160 0.1081 0.2162
27 Tight_junction_hsa04530 4 170 0.127 0.2447
28 Cytokine_cytokine_receptor_interaction_hsa04060 5 270 0.1913 0.3553
29 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.2257 0.4048
30 Endocytosis_hsa04144 4 244 0.2979 0.5007
31 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.3082 0.5007
32 TNF_signaling_pathway_hsa04668 2 108 0.3454 0.5442
33 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.4929 0.712
34 Phagosome_hsa04145 2 152 0.5143 0.7154
35 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.6108 0.7865

Quest ID: 756c0c4e5f017665246808f35bcd24a3