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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-19a-3p ABCA1 2.12 0 -0.92 1.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 0 27445062 The target genes of miR-19a such as ABCA1 and PTEN that had been suppressed by miR recovered their expression through CAP treatment
2 hsa-miR-19a-3p ABCD3 2.12 0 -0.14 0.33401 MirTarget -0.11 0 NA
3 hsa-miR-19a-3p ABHD2 2.12 0 -0.74 0.00059 mirMAP -0.13 8.0E-5 NA
4 hsa-miR-19a-3p ACSL4 2.12 0 -1.28 0 MirTarget; miRNATAP -0.23 0 NA
5 hsa-miR-19a-3p ADAMTSL3 2.12 0 -3.15 0 miRNATAP -0.29 0 NA
6 hsa-miR-19a-3p ADARB1 2.12 0 -1.88 0 mirMAP -0.11 0.00084 NA
7 hsa-miR-19a-3p ADCY9 2.12 0 -1.41 0 miRNATAP -0.19 0 NA
8 hsa-miR-19a-3p AFF2 2.12 0 -2.23 0 mirMAP -0.17 0.02002 NA
9 hsa-miR-19a-3p AKAP2 2.12 0 -2.97 0 mirMAP -0.25 0 NA
10 hsa-miR-19a-3p ANO1 2.12 0 -0.71 0.02851 MirTarget; miRNATAP -0.2 8.0E-5 NA
11 hsa-miR-19a-3p ANTXR1 2.12 0 -0.82 0.00129 MirTarget; mirMAP -0.27 0 NA
12 hsa-miR-19a-3p AR 2.12 0 -1.82 6.0E-5 mirMAP -0.33 0 NA
13 hsa-miR-19a-3p ARAP2 2.12 0 -1.25 0 MirTarget -0.17 0 NA
14 hsa-miR-19a-3p ARC 2.12 0 -3.69 0 miRNATAP -0.17 0.0115 NA
15 hsa-miR-19a-3p ARHGEF12 2.12 0 -0.37 0.00513 MirTarget; mirMAP; miRNATAP -0.1 0 NA
16 hsa-miR-19a-3p ARID5B 2.12 0 -0.45 0.00256 miRNATAP -0.15 0 NA
17 hsa-miR-19a-3p ARL10 2.12 0 -0.26 0.31668 mirMAP -0.12 0.0037 NA
18 hsa-miR-19a-3p ARRDC3 2.12 0 -0.37 0.08066 MirTarget; miRNATAP -0.19 0 NA
19 hsa-miR-19a-3p ARRDC4 2.12 0 -1.29 0 MirTarget; miRNATAP -0.23 0 NA
20 hsa-miR-19a-3p ASXL2 2.12 0 -0.3 0.12837 MirTarget; miRNATAP -0.14 1.0E-5 NA
21 hsa-miR-19a-3p ATL3 2.12 0 0.11 0.46975 mirMAP -0.15 0 NA
22 hsa-miR-19a-3p ATP10A 2.12 0 -1.58 0 MirTarget -0.33 0 NA
23 hsa-miR-19a-3p ATP1A2 2.12 0 -3.15 0 MirTarget -0.37 0 NA
24 hsa-miR-19a-3p ATP6V0E1 2.12 0 -0.18 0.15468 MirTarget -0.11 0 NA
25 hsa-miR-19a-3p ATP6V1B2 2.12 0 -0.66 0 MirTarget; miRNATAP -0.13 0 NA
26 hsa-miR-19a-3p ATP8A2 2.12 0 -2 0 mirMAP -0.28 4.0E-5 NA
27 hsa-miR-19a-3p ATRX 2.12 0 -0.09 0.47606 MirTarget; miRNATAP -0.11 0 NA
28 hsa-miR-19a-3p ATXN1 2.12 0 -0.47 0.0003 miRNAWalker2 validate; miRTarBase; miRNATAP -0.13 0 NA
29 hsa-miR-19a-3p ATXN1L 2.12 0 -0.66 0 miRNATAP -0.11 0 NA
30 hsa-miR-19a-3p BBX 2.12 0 -0.3 0.02503 MirTarget; miRNATAP -0.11 0 NA
31 hsa-miR-19a-3p BCAT1 2.12 0 -0.21 0.54581 MirTarget; mirMAP -0.19 0.00078 NA
32 hsa-miR-19a-3p BMP3 2.12 0 -1.37 0.01092 MirTarget -0.38 1.0E-5 NA
33 hsa-miR-19a-3p BMPER 2.12 0 -3.66 0 miRNATAP -0.27 0.00037 NA
34 hsa-miR-19a-3p BMPR2 2.12 0 -1.25 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
35 hsa-miR-19a-3p BNC2 2.12 0 -1.12 1.0E-5 MirTarget; miRNATAP -0.22 0 NA
36 hsa-miR-19a-3p C10orf105 2.12 0 -2.08 0 mirMAP -0.13 0.00728 NA
37 hsa-miR-19a-3p C3orf70 2.12 0 -1.59 0 miRNATAP -0.13 0.00293 NA
38 hsa-miR-19a-3p C5orf24 2.12 0 -0.34 0.00325 mirMAP -0.11 0 NA
39 hsa-miR-19a-3p CAB39 2.12 0 -0.11 0.30508 MirTarget; miRNATAP -0.12 0 NA
40 hsa-miR-19a-3p CACNA1C 2.12 0 -1.13 2.0E-5 MirTarget -0.17 3.0E-5 NA
41 hsa-miR-19a-3p CASP10 2.12 0 -0.27 0.09806 MirTarget; mirMAP -0.1 6.0E-5 NA
42 hsa-miR-19a-3p CAST 2.12 0 -0.37 0.00369 miRNATAP -0.17 0 NA
43 hsa-miR-19a-3p CBX7 2.12 0 -1.83 0 mirMAP; miRNATAP -0.15 1.0E-5 NA
44 hsa-miR-19a-3p CCDC126 2.12 0 -0.19 0.16106 MirTarget; miRNATAP -0.11 0 NA
45 hsa-miR-19a-3p CCDC8 2.12 0 -1.16 3.0E-5 MirTarget -0.11 0.00892 NA
46 hsa-miR-19a-3p CCND1 2.12 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; miRNATAP -0.22 0 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression
47 hsa-miR-19a-3p CCND2 2.12 0 -1.64 0 MirTarget; miRNATAP -0.17 1.0E-5 NA
48 hsa-miR-19a-3p CCNT1 2.12 0 -0.35 0.14552 mirMAP -0.16 2.0E-5 NA
49 hsa-miR-19a-3p CCPG1 2.12 0 -0.26 0.07928 MirTarget -0.19 0 NA
50 hsa-miR-19a-3p CD164 2.12 0 -0.08 0.50906 miRNATAP -0.14 0 NA
51 hsa-miR-19a-3p CD47 2.12 0 -0.76 2.0E-5 MirTarget -0.16 0 NA
52 hsa-miR-19a-3p CD69 2.12 0 -1.61 0 miRNATAP -0.25 0 NA
53 hsa-miR-19a-3p CD84 2.12 0 -0.48 0.13309 MirTarget -0.28 0 NA
54 hsa-miR-19a-3p CDC42BPA 2.12 0 0.13 0.56325 MirTarget; miRNATAP -0.11 0.00215 NA
55 hsa-miR-19a-3p CDH13 2.12 0 -2.32 0 MirTarget -0.24 0 NA
56 hsa-miR-19a-3p CDHR1 2.12 0 -1.19 0.00175 MirTarget -0.14 0.02015 NA
57 hsa-miR-19a-3p CDKN2B 2.12 0 -1.65 0 mirMAP -0.11 0.02151 NA
58 hsa-miR-19a-3p CDS1 2.12 0 -0.26 0.14104 miRNATAP -0.12 3.0E-5 NA
59 hsa-miR-19a-3p CLIP4 2.12 0 -0.78 3.0E-5 MirTarget; miRNATAP -0.11 0.00032 NA
60 hsa-miR-19a-3p CLOCK 2.12 0 0.04 0.82828 MirTarget -0.13 0 NA
61 hsa-miR-19a-3p CNKSR2 2.12 0 -3.17 0 MirTarget; miRNATAP -0.27 0.00014 NA
62 hsa-miR-19a-3p CNOT6L 2.12 0 -0.36 0.00099 mirMAP -0.12 0 NA
63 hsa-miR-19a-3p CNTFR 2.12 0 -4.21 0 miRNATAP -0.17 0.03904 NA
64 hsa-miR-19a-3p CPEB4 2.12 0 -0.54 0.00017 mirMAP; miRNATAP -0.15 0 NA
65 hsa-miR-19a-3p CREBL2 2.12 0 -0.66 0 miRNATAP -0.18 0 NA
66 hsa-miR-19a-3p CSF2RB 2.12 0 -1.28 0 MirTarget -0.17 4.0E-5 NA
67 hsa-miR-19a-3p CTGF 2.12 0 -1.94 0 MirTarget; miRNATAP -0.25 0 NA
68 hsa-miR-19a-3p CYLD 2.12 0 -0.44 0.00061 miRNATAP -0.14 0 NA
69 hsa-miR-19a-3p CYP2U1 2.12 0 -1.2 0 MirTarget -0.25 0 NA
70 hsa-miR-19a-3p DAAM1 2.12 0 -0.44 0.00894 miRNATAP -0.14 0 NA
71 hsa-miR-19a-3p DCBLD2 2.12 0 0.33 0.24787 MirTarget; mirMAP; miRNATAP -0.11 0.01064 NA
72 hsa-miR-19a-3p DKK3 2.12 0 -1.58 0 miRNATAP -0.3 0 NA
73 hsa-miR-19a-3p DLC1 2.12 0 -2.53 0 mirMAP; miRNATAP -0.29 0 NA
74 hsa-miR-19a-3p DLG2 2.12 0 -0.4 0.15229 mirMAP -0.17 0.00016 NA
75 hsa-miR-19a-3p DNAJB14 2.12 0 -0.4 0.00192 mirMAP -0.15 0 NA
76 hsa-miR-19a-3p DOCK10 2.12 0 -0.36 0.1383 miRNATAP -0.18 0 NA
77 hsa-miR-19a-3p DOK6 2.12 0 -1.82 0 mirMAP -0.19 0.00027 NA
78 hsa-miR-19a-3p DPYSL2 2.12 0 -1.8 0 miRNAWalker2 validate -0.26 0 NA
79 hsa-miR-19a-3p DSEL 2.12 0 -0.89 0.00132 MirTarget; miRNATAP -0.15 0.00061 NA
80 hsa-miR-19a-3p EBF1 2.12 0 -1.4 0 miRNATAP -0.15 1.0E-5 NA
81 hsa-miR-19a-3p EEA1 2.12 0 -0.47 0.00057 mirMAP; miRNATAP -0.15 0 NA
82 hsa-miR-19a-3p EFNB2 2.12 0 -1.34 0 miRNATAP -0.25 0 NA
83 hsa-miR-19a-3p EFR3A 2.12 0 0.12 0.37998 MirTarget -0.11 0 NA
84 hsa-miR-19a-3p ELK3 2.12 0 -0.48 0.01994 MirTarget; miRNATAP -0.25 0 NA
85 hsa-miR-19a-3p ENC1 2.12 0 1 0 MirTarget -0.14 5.0E-5 NA
86 hsa-miR-19a-3p ENDOD1 2.12 0 0.06 0.80229 mirMAP -0.24 0 NA
87 hsa-miR-19a-3p ERBB4 2.12 0 -3.26 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.28 0.00034 NA
88 hsa-miR-19a-3p ESR1 2.12 0 -0.26 0.51027 miRNAWalker2 validate; miRTarBase; miRNATAP -0.21 0.00065 26416600 We speculate that miR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1 which influences the occurrence and development of breast cancer cells with different levels of ER expression
89 hsa-miR-19a-3p ETV1 2.12 0 -1.79 0 MirTarget; miRNATAP -0.43 0 NA
90 hsa-miR-19a-3p ETV5 2.12 0 -1.43 0 MirTarget; miRNATAP -0.25 0 NA
91 hsa-miR-19a-3p EVI5 2.12 0 -0.65 0 mirMAP -0.11 0 NA
92 hsa-miR-19a-3p F3 2.12 0 -0.75 0.02302 MirTarget; miRNATAP -0.15 0.00496 NA
93 hsa-miR-19a-3p FAM114A1 2.12 0 0.58 0.00084 MirTarget; miRNATAP -0.13 0 NA
94 hsa-miR-19a-3p FAM155A 2.12 0 -1.07 0.00464 MirTarget -0.22 0.0002 NA
95 hsa-miR-19a-3p FAM168A 2.12 0 -0.32 0.09708 MirTarget; mirMAP -0.12 0.00011 NA
96 hsa-miR-19a-3p FAM46B 2.12 0 -3.17 0 MirTarget; miRNATAP -0.12 0.01911 NA
97 hsa-miR-19a-3p FAM46C 2.12 0 -0.22 0.37961 mirMAP; miRNATAP -0.18 0 NA
98 hsa-miR-19a-3p FAT3 2.12 0 -3.31 0 mirMAP; miRNATAP -0.17 0.01455 NA
99 hsa-miR-19a-3p FBXL7 2.12 0 -1.42 0 mirMAP -0.16 0 NA
100 hsa-miR-19a-3p FBXO8 2.12 0 -0.44 2.0E-5 MirTarget; miRNATAP -0.13 0 NA
101 hsa-miR-19a-3p FBXW11 2.12 0 -0.3 0.01022 MirTarget -0.14 0 NA
102 hsa-miR-19a-3p FEM1C 2.12 0 -0.53 6.0E-5 miRNATAP -0.15 0 NA
103 hsa-miR-19a-3p FIBIN 2.12 0 -2.56 0 MirTarget -0.31 0 NA
104 hsa-miR-19a-3p FOXF2 2.12 0 -1.7 0 miRNATAP -0.35 0 NA
105 hsa-miR-19a-3p FOXP1 2.12 0 -0.66 1.0E-5 MirTarget; mirMAP; miRNATAP -0.14 0 26367773 The four miR-19a target cDNA expression vectors suppressed cell viability colony formation migration and invasion of A549 and LK79 cells but LK79 cells transfected with FOXP1 and TP53INP1 cDNAs showed no difference compared to the control cells in the invasion assay
106 hsa-miR-19a-3p G3BP2 2.12 0 -0.04 0.75462 MirTarget; miRNATAP -0.1 0 NA
107 hsa-miR-19a-3p GAS7 2.12 0 -1.49 0 mirMAP -0.27 0 NA
108 hsa-miR-19a-3p GIMAP6 2.12 0 -2.32 0 mirMAP -0.26 0 NA
109 hsa-miR-19a-3p GJA1 2.12 0 -1.74 0 MirTarget; miRNATAP -0.22 1.0E-5 NA
110 hsa-miR-19a-3p GLIPR1 2.12 0 -0.68 0.00145 mirMAP -0.22 0 NA
111 hsa-miR-19a-3p GLIS3 2.12 0 -0.08 0.7529 mirMAP -0.19 0 NA
112 hsa-miR-19a-3p GNAQ 2.12 0 -1.17 0 MirTarget; mirMAP -0.18 0 NA
113 hsa-miR-19a-3p GPM6B 2.12 0 -2.41 0 mirMAP -0.1 0.03166 NA
114 hsa-miR-19a-3p GTF2A1 2.12 0 -0.14 0.4882 MirTarget; miRNATAP -0.2 0 NA
115 hsa-miR-19a-3p GZMK 2.12 0 -0.03 0.92425 MirTarget -0.14 0.01715 NA
116 hsa-miR-19a-3p HBP1 2.12 0 -0.42 0.00016 MirTarget; miRNATAP -0.13 0 NA
117 hsa-miR-19a-3p HCFC2 2.12 0 -0.62 0 MirTarget -0.14 0 NA
118 hsa-miR-19a-3p HEG1 2.12 0 -2.36 0 mirMAP; miRNATAP -0.23 0 NA
119 hsa-miR-19a-3p HIP1 2.12 0 -0.83 0.00018 MirTarget -0.22 0 NA
120 hsa-miR-19a-3p HIPK1 2.12 0 -0.53 2.0E-5 MirTarget; mirMAP; miRNATAP -0.12 0 NA
121 hsa-miR-19a-3p HIPK3 2.12 0 -1.01 0 MirTarget; miRNATAP -0.26 0 NA
122 hsa-miR-19a-3p HLF 2.12 0 -2.49 0 miRNATAP -0.39 0 NA
123 hsa-miR-19a-3p HOXA5 2.12 0 -1.79 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.14 0.00058 NA
124 hsa-miR-19a-3p ICOS 2.12 0 -1.03 0.001 mirMAP -0.12 0.01471 NA
125 hsa-miR-19a-3p IGF1 2.12 0 -0.88 0.00545 MirTarget -0.3 0 NA
126 hsa-miR-19a-3p IGF2 2.12 0 -1.09 0.0418 mirMAP -0.17 0.04576 NA
127 hsa-miR-19a-3p IKZF1 2.12 0 -0.95 0.00018 mirMAP -0.22 0 NA
128 hsa-miR-19a-3p IL1RAP 2.12 0 0 0.99919 MirTarget -0.2 0 NA
129 hsa-miR-19a-3p IL6ST 2.12 0 -1.4 0 mirMAP; miRNATAP -0.38 0 NA
130 hsa-miR-19a-3p IPCEF1 2.12 0 0.31 0.35323 mirMAP -0.22 3.0E-5 NA
131 hsa-miR-19a-3p ITGA2 2.12 0 0.82 0.02366 MirTarget -0.25 1.0E-5 NA
132 hsa-miR-19a-3p ITGB8 2.12 0 0.34 0.46013 MirTarget -0.29 6.0E-5 NA
133 hsa-miR-19a-3p ITPR1 2.12 0 -1.22 0 MirTarget; miRNATAP -0.16 1.0E-5 NA
134 hsa-miR-19a-3p JAM2 2.12 0 -2.67 0 miRNATAP -0.25 0 NA
135 hsa-miR-19a-3p JAZF1 2.12 0 -0.97 0 MirTarget -0.19 0 NA
136 hsa-miR-19a-3p KAT2B 2.12 0 -1.27 0 miRNAWalker2 validate -0.23 0 NA
137 hsa-miR-19a-3p KBTBD11 2.12 0 -0.82 0.00476 mirMAP -0.16 0.00059 NA
138 hsa-miR-19a-3p KBTBD8 2.12 0 -0.82 0.00029 MirTarget -0.18 0 NA
139 hsa-miR-19a-3p KCNA1 2.12 0 -0.61 0.22469 mirMAP -0.23 0.0037 NA
140 hsa-miR-19a-3p KCNA4 2.12 0 -5.11 0 MirTarget; miRNATAP -0.41 0 NA
141 hsa-miR-19a-3p KCNJ2 2.12 0 -1.33 0 MirTarget; miRNATAP -0.16 0.00026 NA
142 hsa-miR-19a-3p KCNJ5 2.12 0 -2.49 0 mirMAP -0.33 0 NA
143 hsa-miR-19a-3p KCNQ5 2.12 0 1.52 0.0012 MirTarget -0.19 0.00934 NA
144 hsa-miR-19a-3p KCTD12 2.12 0 -1.56 0 mirMAP -0.3 0 NA
145 hsa-miR-19a-3p KIAA0513 2.12 0 -0.71 0.00012 mirMAP -0.1 0.00034 NA
146 hsa-miR-19a-3p KIAA2022 2.12 0 -0.86 0.09254 mirMAP -0.3 0.00018 NA
147 hsa-miR-19a-3p KIF6 2.12 0 -1.88 2.0E-5 mirMAP -0.18 0.00794 NA
148 hsa-miR-19a-3p KITLG 2.12 0 -0.41 0.09469 mirMAP -0.18 0 NA
149 hsa-miR-19a-3p KLF10 2.12 0 -1 0 miRNATAP -0.13 0 NA
150 hsa-miR-19a-3p KLF13 2.12 0 -1.61 0 miRNATAP -0.13 1.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 66 1426 5.657e-13 2.632e-09
2 POSITIVE REGULATION OF GENE EXPRESSION 68 1733 3.853e-10 8.965e-07
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 65 1672 1.49e-09 2.31e-06
4 TISSUE DEVELOPMENT 60 1518 3.889e-09 4.523e-06
5 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 66 1805 1.253e-08 1.043e-05
6 REGULATION OF CELL DIFFERENTIATION 58 1492 1.344e-08 1.043e-05
7 NEUROGENESIS 55 1402 2.496e-08 1.588e-05
8 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 48 1142 2.73e-08 1.588e-05
9 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 44 1004 3.35e-08 1.732e-05
10 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 6 14 8.12e-08 3.778e-05
11 REGULATION OF CELL PROLIFERATION 56 1496 8.965e-08 3.792e-05
12 NEURON DIFFERENTIATION 39 874 1.36e-07 5.273e-05
13 NEGATIVE REGULATION OF CELL PROLIFERATION 32 643 1.798e-07 6.434e-05
14 SKELETAL SYSTEM DEVELOPMENT 26 455 1.978e-07 6.576e-05
15 EPITHELIAL CELL DEVELOPMENT 16 186 2.365e-07 6.878e-05
16 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 62 1784 2.332e-07 6.878e-05
17 POSITIVE REGULATION OF MOLECULAR FUNCTION 62 1791 2.674e-07 7.318e-05
18 EPITHELIAL CELL DIFFERENTIATION 27 495 2.893e-07 7.479e-05
19 CARDIOVASCULAR SYSTEM DEVELOPMENT 35 788 6.941e-07 0.0001615
20 CIRCULATORY SYSTEM DEVELOPMENT 35 788 6.941e-07 0.0001615
21 REGULATION OF TRANSPORT 61 1804 7.537e-07 0.000167
22 REGULATION OF EPITHELIAL CELL PROLIFERATION 19 285 9.417e-07 0.0001969
23 MUSCLE STRUCTURE DEVELOPMENT 24 432 9.735e-07 0.0001969
24 POSITIVE REGULATION OF CATALYTIC ACTIVITY 53 1518 1.766e-06 0.0003285
25 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 50 1395 1.718e-06 0.0003285
26 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 26 513 1.906e-06 0.0003285
27 POSITIVE REGULATION OF CELL DIFFERENTIATION 35 823 1.867e-06 0.0003285
28 NEGATIVE REGULATION OF GENE EXPRESSION 52 1493 2.408e-06 0.0003863
29 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 724 2.368e-06 0.0003863
30 EPITHELIUM DEVELOPMENT 38 945 2.515e-06 0.0003901
31 REGULATION OF ION TRANSPORT 28 592 2.909e-06 0.0004366
32 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 21 368 3.086e-06 0.0004487
33 NEURON PROJECTION MORPHOGENESIS 22 402 3.539e-06 0.0004843
34 CARDIAC MUSCLE CELL ACTION POTENTIAL 7 37 3.47e-06 0.0004843
35 CELL COMMUNICATION BY ELECTRICAL COUPLING 5 15 4.505e-06 0.000599
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 51 1492 5.179e-06 0.0006648
37 CELLULAR COMPONENT MORPHOGENESIS 36 900 5.287e-06 0.0006648
38 TUBE DEVELOPMENT 26 552 7.138e-06 0.0008741
39 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 39 1036 8.716e-06 0.001014
40 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 39 1036 8.716e-06 0.001014
41 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 54 1656 1.033e-05 0.001152
42 INTRACELLULAR SIGNAL TRANSDUCTION 52 1572 1.04e-05 0.001152
43 RESPONSE TO ENDOGENOUS STIMULUS 49 1450 1.102e-05 0.001176
44 REGULATION OF PHOSPHORUS METABOLIC PROCESS 53 1618 1.112e-05 0.001176
45 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 41 1135 1.347e-05 0.001392
46 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 38 1021 1.477e-05 0.001494
47 NEURON DEVELOPMENT 29 687 1.697e-05 0.001678
48 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 50 1517 1.731e-05 0.001678
49 HEART PROCESS 9 85 2.031e-05 0.001928
50 REGULATION OF CELLULAR COMPONENT MOVEMENT 31 771 2.223e-05 0.002068
51 MUSCLE CELL DIFFERENTIATION 15 237 2.437e-05 0.002224
52 REGULATION OF PROTEIN MODIFICATION PROCESS 54 1710 2.53e-05 0.002247
53 RESPONSE TO MECHANICAL STIMULUS 14 210 2.559e-05 0.002247
54 VASCULATURE DEVELOPMENT 22 469 3.877e-05 0.00334
55 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 10 115 4.006e-05 0.003389
56 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 43 1275 4.208e-05 0.003496
57 NEURON PROJECTION DEVELOPMENT 24 545 4.744e-05 0.003687
58 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 28 689 4.651e-05 0.003687
59 ORGAN MORPHOGENESIS 32 841 4.754e-05 0.003687
60 ACTION POTENTIAL 9 94 4.56e-05 0.003687
61 GROWTH 20 410 5.079e-05 0.003874
62 REGULATION OF POSITIVE CHEMOTAXIS 5 24 5.589e-05 0.004194
63 REGULATION OF PEPTIDE TRANSPORT 15 256 5.917e-05 0.004302
64 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 36 1008 5.897e-05 0.004302
65 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 6 39 6.058e-05 0.004316
66 RELAXATION OF CARDIAC MUSCLE 4 13 6.215e-05 0.004316
67 POSITIVE REGULATION OF CELL PROLIFERATION 31 814 6.16e-05 0.004316
68 REGULATION OF CELL PROJECTION ORGANIZATION 24 558 6.853e-05 0.004689
69 MULTICELLULAR ORGANISMAL SIGNALING 10 123 7.112e-05 0.004796
70 NEURON PROJECTION GUIDANCE 13 205 8.27e-05 0.005497
71 REGULATION OF TRANSMEMBRANE TRANSPORT 20 426 8.592e-05 0.005631
72 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 207 9.124e-05 0.005896
73 LOCOMOTION 38 1114 9.574e-05 0.005966
74 REGULATION OF CHEMOTAXIS 12 180 9.617e-05 0.005966
75 GLAND DEVELOPMENT 19 395 9.388e-05 0.005966
76 HEART DEVELOPMENT 21 466 0.0001022 0.006258
77 RESPONSE TO ORGANIC CYCLIC COMPOUND 33 917 0.0001051 0.00635
78 DEVELOPMENTAL GROWTH 17 333 0.0001072 0.006392
79 POSITIVE REGULATION OF MAPK CASCADE 21 470 0.0001151 0.006781
80 POSITIVE REGULATION OF OSSIFICATION 8 84 0.0001252 0.007281
81 REGULATION OF MAPK CASCADE 26 660 0.0001431 0.008137
82 RESPONSE TO HORMONE 32 893 0.0001448 0.008137
83 CARDIAC MUSCLE CELL CONTRACTION 5 29 0.0001451 0.008137
84 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 28 740 0.0001564 0.008665
85 REGULATION OF HOMEOSTATIC PROCESS 20 447 0.0001639 0.008971
86 LENS DEVELOPMENT IN CAMERA TYPE EYE 7 66 0.0001687 0.009128
87 OSSIFICATION 14 251 0.000174 0.009201
88 CELL PROJECTION ORGANIZATION 32 902 0.0001735 0.009201
89 CELL PART MORPHOGENESIS 25 633 0.0001846 0.009575
90 REGULATION OF CELL JUNCTION ASSEMBLY 7 68 0.0002037 0.009575
91 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 750 0.0001951 0.009575
92 CELL PROLIFERATION 26 672 0.00019 0.009575
93 ENDOTHELIUM DEVELOPMENT 8 90 0.000203 0.009575
94 ORGAN GROWTH 7 68 0.0002037 0.009575
95 MAMMARY GLAND ALVEOLUS DEVELOPMENT 4 17 0.0001955 0.009575
96 CONNECTIVE TISSUE DEVELOPMENT 12 194 0.0001946 0.009575
97 MAMMARY GLAND LOBULE DEVELOPMENT 4 17 0.0001955 0.009575
98 POST EMBRYONIC DEVELOPMENT 8 89 0.0001878 0.009575
99 BIOLOGICAL ADHESION 35 1032 0.0002037 0.009575
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATORY REGION NUCLEIC ACID BINDING 35 818 1.628e-06 0.0007562
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 20 315 1.045e-06 0.0007562
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 29 629 3.177e-06 0.0009837
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 19 328 7.376e-06 0.00137
5 LIPID BINDING 29 657 7.347e-06 0.00137
6 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 43 1199 9.732e-06 0.001507
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 15 226 1.393e-05 0.001849
NumGOOverlapSizeP ValueAdj. P Value
1 INTRINSIC COMPONENT OF PLASMA MEMBRANE 58 1649 4.151e-07 0.0002345
2 ENDOSOME 35 793 8.03e-07 0.0002345
3 EARLY ENDOSOME 19 301 2.123e-06 0.0004133
4 NEURON PART 45 1265 7.29e-06 0.001064
5 VACUOLE 41 1180 3.301e-05 0.003298
6 NEURON PROJECTION 35 942 3.388e-05 0.003298
7 T TUBULE 6 45 0.0001383 0.008971
8 SOMATODENDRITIC COMPARTMENT 26 650 0.0001122 0.008971
9 PLASMA MEMBRANE PROTEIN COMPLEX 22 510 0.0001317 0.008971

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 17 295 2.381e-05 0.001238
2 Cellular_senescence_hsa04218 10 160 0.0006047 0.007621
3 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.0006987 0.007621
4 Apelin_signaling_pathway_hsa04371 9 137 0.0007883 0.007621
5 Focal_adhesion_hsa04510 11 199 0.0009128 0.007621
6 Tight_junction_hsa04530 10 170 0.0009653 0.007621
7 Rap1_signaling_pathway_hsa04015 11 206 0.001208 0.007621
8 Wnt_signaling_pathway_hsa04310 9 146 0.001237 0.007621
9 p53_signaling_pathway_hsa04115 6 68 0.001319 0.007621
10 Oocyte_meiosis_hsa04114 8 124 0.001713 0.008905
11 FoxO_signaling_pathway_hsa04068 8 132 0.002536 0.01199
12 ECM_receptor_interaction_hsa04512 6 82 0.00343 0.01394
13 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 8 139 0.003485 0.01394
14 Gap_junction_hsa04540 6 88 0.00486 0.01805
15 Phagosome_hsa04145 8 152 0.005955 0.02064
16 Hippo_signaling_pathway_hsa04390 8 154 0.00643 0.0209
17 Hedgehog_signaling_pathway_hsa04340 4 47 0.009642 0.02949
18 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.01526 0.04408
19 TGF_beta_signaling_pathway_hsa04350 5 84 0.01707 0.04673
20 mTOR_signaling_pathway_hsa04150 7 151 0.01865 0.04716
21 Sphingolipid_signaling_pathway_hsa04071 6 118 0.01905 0.04716
22 Ras_signaling_pathway_hsa04014 9 232 0.02358 0.05573
23 Autophagy_animal_hsa04140 6 128 0.02711 0.06129
24 Calcium_signaling_pathway_hsa04020 7 182 0.04473 0.09692
25 PI3K_Akt_signaling_pathway_hsa04151 11 352 0.05136 0.1068
26 cAMP_signaling_pathway_hsa04024 7 198 0.06448 0.129
27 Jak_STAT_signaling_pathway_hsa04630 6 162 0.07008 0.135
28 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.1005 0.1866
29 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.1106 0.1983
30 Ferroptosis_hsa04216 2 40 0.159 0.2755
31 ABC_transporters_hsa02010 2 45 0.1908 0.3201
32 Apoptosis_hsa04210 4 138 0.2317 0.3765
33 TNF_signaling_pathway_hsa04668 3 108 0.3021 0.476
34 AMPK_signaling_pathway_hsa04152 3 121 0.3654 0.5487
35 Lysosome_hsa04142 3 123 0.375 0.5487
36 Cell_cycle_hsa04110 3 124 0.3799 0.5487
37 Peroxisome_hsa04146 2 83 0.4364 0.5829
38 ErbB_signaling_pathway_hsa04012 2 85 0.4484 0.5829
39 Endocytosis_hsa04144 4 244 0.6342 0.7852
40 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.7191 0.8146
41 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.7363 0.8146
42 Necroptosis_hsa04217 2 164 0.7924 0.8584

Quest ID: 77e606344fec1324b144377fcbc13c9a