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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200b-3p ABAT -1.29 0.00027 -2.16 0 MirTarget; TargetScan -0.2 0 NA
2 hsa-miR-200c-3p ABAT -0.1 0.71696 -2.16 0 MirTarget -0.29 0 NA
3 hsa-miR-200c-3p ACADSB -0.1 0.71696 -2.11 0 mirMAP -0.14 0.00013 NA
4 hsa-miR-200c-3p ACE2 -0.1 0.71696 -2.26 0 miRNATAP -0.23 0.00499 NA
5 hsa-miR-200b-3p ACVR1C -1.29 0.00027 -2.2 0 TargetScan -0.18 0 NA
6 hsa-miR-200a-5p ADI1 -1.17 0.00105 -1.25 0 MirTarget -0.17 0 NA
7 hsa-miR-200c-3p AMFR -0.1 0.71696 -0.44 3.0E-5 miRNATAP -0.13 0 NA
8 hsa-miR-200b-3p ANGPTL3 -1.29 0.00027 -1.81 0 TargetScan -0.13 0.00277 NA
9 hsa-miR-200a-3p ANO5 -1.5 3.0E-5 -1.28 0.00055 mirMAP -0.12 0.01856 NA
10 hsa-miR-200b-3p ANO5 -1.29 0.00027 -1.28 0.00055 TargetScan -0.13 0.00908 NA
11 hsa-miR-200a-3p AR -1.5 3.0E-5 -2.66 0 mirMAP -0.32 0 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells
12 hsa-miR-200a-5p AR -1.17 0.00105 -2.66 0 miRNATAP -0.33 0 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells
13 hsa-miR-200b-3p ARPP21 -1.29 0.00027 -2.21 0 MirTarget -0.14 0.01222 NA
14 hsa-miR-200c-3p ARPP21 -0.1 0.71696 -2.21 0 MirTarget; miRNATAP -0.18 0.00835 NA
15 hsa-miR-200b-3p ASXL3 -1.29 0.00027 -2.69 0 TargetScan -0.17 0.00117 NA
16 hsa-miR-200b-3p ATP11C -1.29 0.00027 -1.6 0 MirTarget; TargetScan -0.15 0 NA
17 hsa-miR-200c-3p ATP11C -0.1 0.71696 -1.6 0 MirTarget -0.16 0 NA
18 hsa-miR-200b-3p BAGE -1.29 0.00027 1.25 0.00088 MirTarget -0.23 1.0E-5 NA
19 hsa-miR-200c-3p BLCAP -0.1 0.71696 -0.41 0.00021 MirTarget -0.13 0 NA
20 hsa-miR-200a-3p C1orf21 -1.5 3.0E-5 -0.75 0.00045 miRNATAP -0.12 4.0E-5 NA
21 hsa-miR-200a-3p CADM1 -1.5 3.0E-5 -0.03 0.88629 MirTarget -0.12 0 NA
22 hsa-miR-200b-3p CADM1 -1.29 0.00027 -0.03 0.88629 TargetScan -0.13 0 NA
23 hsa-miR-200c-3p CAMK1D -0.1 0.71696 -0.4 0.12354 mirMAP -0.11 0.01155 NA
24 hsa-miR-200a-3p CDC14B -1.5 3.0E-5 -1.19 0 mirMAP -0.15 0 NA
25 hsa-miR-200c-3p CDK6 -0.1 0.71696 -0.31 0.22057 mirMAP -0.12 0.00446 NA
26 hsa-miR-200b-3p CECR2 -1.29 0.00027 -0.78 0.01282 TargetScan -0.3 0 NA
27 hsa-miR-200b-3p CFL2 -1.29 0.00027 -1.18 0 MirTarget; TargetScan -0.15 0 NA
28 hsa-miR-200c-3p CFL2 -0.1 0.71696 -1.18 0 MirTarget; miRNATAP -0.17 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
29 hsa-miR-200b-3p CHN2 -1.29 0.00027 -0.87 0 MirTarget; TargetScan -0.15 0 NA
30 hsa-miR-200c-3p CHN2 -0.1 0.71696 -0.87 0 MirTarget -0.17 0 NA
31 hsa-miR-200c-3p CNN3 -0.1 0.71696 0 0.99816 MirTarget; miRNATAP -0.11 0 NA
32 hsa-miR-200a-3p CPLX2 -1.5 3.0E-5 5.16 0 mirMAP -0.38 0.00019 NA
33 hsa-miR-200a-5p CPLX2 -1.17 0.00105 5.16 0 mirMAP -0.36 0.00043 NA
34 hsa-miR-200a-5p CYP4F3 -1.17 0.00105 -1.55 0 MirTarget -0.17 2.0E-5 NA
35 hsa-miR-200a-5p DAB1 -1.17 0.00105 -2.13 0 mirMAP -0.18 0.00027 NA
36 hsa-miR-200a-3p DDI2 -1.5 3.0E-5 -1.53 0 mirMAP -0.16 0.00038 NA
37 hsa-miR-200a-3p DIO2 -1.5 3.0E-5 1.75 4.0E-5 miRNATAP -0.16 0.00503 NA
38 hsa-miR-200b-3p DMD -1.29 0.00027 -1.66 0 TargetScan -0.11 0.00013 NA
39 hsa-miR-200c-3p DMD -0.1 0.71696 -1.66 0 miRNATAP -0.13 0.00016 NA
40 hsa-miR-200c-3p DNAJB9 -0.1 0.71696 -0.63 0 miRNATAP -0.12 0 NA
41 hsa-miR-200c-3p DUSP1 -0.1 0.71696 -2.02 0 MirTarget; miRNATAP -0.1 0.00452 NA
42 hsa-miR-200a-3p DYNC1I1 -1.5 3.0E-5 1.67 1.0E-5 MirTarget -0.27 0 NA
43 hsa-miR-200b-3p DYNC1I1 -1.29 0.00027 1.67 1.0E-5 MirTarget -0.24 1.0E-5 NA
44 hsa-miR-200c-3p DYNC1I1 -0.1 0.71696 1.67 1.0E-5 MirTarget -0.16 0.01449 NA
45 hsa-miR-200b-3p ELL2 -1.29 0.00027 -0.77 0 MirTarget; TargetScan -0.11 0 NA
46 hsa-miR-200c-3p ELL2 -0.1 0.71696 -0.77 0 MirTarget -0.16 0 NA
47 hsa-miR-200b-3p ENPEP -1.29 0.00027 -1.55 0 mirMAP -0.18 0 NA
48 hsa-miR-200c-3p ENTPD5 -0.1 0.71696 -1.12 0 MirTarget -0.11 0.00089 NA
49 hsa-miR-200b-3p ESM1 -1.29 0.00027 4.21 0 MirTarget -0.26 0 NA
50 hsa-miR-200a-3p FAM133A -1.5 3.0E-5 1.84 0.00087 mirMAP -0.44 0 NA
51 hsa-miR-200a-3p FAM169A -1.5 3.0E-5 0.37 0.13291 mirMAP -0.19 0 NA
52 hsa-miR-200b-3p FGF12 -1.29 0.00027 1.13 0.00013 TargetScan -0.17 3.0E-5 NA
53 hsa-miR-200b-3p FGF2 -1.29 0.00027 -1.09 0.00032 mirMAP -0.17 4.0E-5 NA
54 hsa-miR-200c-3p FGF2 -0.1 0.71696 -1.09 0.00032 mirMAP -0.16 0.00234 NA
55 hsa-miR-200a-5p FITM2 -1.17 0.00105 0.37 0.00294 mirMAP -0.14 0 NA
56 hsa-miR-200b-3p FSTL4 -1.29 0.00027 3.14 0 TargetScan -0.12 0.03642 NA
57 hsa-miR-200b-3p G6PC -1.29 0.00027 -1.88 0 MirTarget; TargetScan -0.13 0.00805 NA
58 hsa-miR-200c-3p G6PC -0.1 0.71696 -1.88 0 MirTarget -0.24 9.0E-5 NA
59 hsa-miR-200a-3p GFRA1 -1.5 3.0E-5 -2.55 0 mirMAP -0.24 0.0001 NA
60 hsa-miR-200a-5p GFRA1 -1.17 0.00105 -2.55 0 mirMAP -0.27 2.0E-5 NA
61 hsa-miR-200b-3p GFRA1 -1.29 0.00027 -2.55 0 mirMAP -0.24 0.00014 NA
62 hsa-miR-200c-3p GFRA1 -0.1 0.71696 -2.55 0 mirMAP -0.32 5.0E-5 NA
63 hsa-miR-200a-3p GFRA2 -1.5 3.0E-5 -1.04 0 mirMAP -0.11 0.00014 NA
64 hsa-miR-200a-3p GLRX -1.5 3.0E-5 -0.98 0 MirTarget; miRNATAP -0.15 0 NA
65 hsa-miR-200b-3p GLRX -1.29 0.00027 -0.98 0 MirTarget -0.17 0 NA
66 hsa-miR-200c-3p GLRX -0.1 0.71696 -0.98 0 MirTarget -0.16 0 NA
67 hsa-miR-200a-5p GLUL -1.17 0.00105 0.44 0.12619 MirTarget -0.2 0 NA
68 hsa-miR-200a-3p GNE -1.5 3.0E-5 -1.82 0 MirTarget -0.12 0 NA
69 hsa-miR-200c-3p GOT1 -0.1 0.71696 -1.38 0 MirTarget -0.12 0.00026 NA
70 hsa-miR-200a-3p GPAM -1.5 3.0E-5 -0.47 0.0638 MirTarget -0.15 1.0E-5 NA
71 hsa-miR-200b-3p GPR146 -1.29 0.00027 -1.58 0 TargetScan -0.11 0 NA
72 hsa-miR-200c-3p GPR146 -0.1 0.71696 -1.58 0 miRNATAP -0.16 0 NA
73 hsa-miR-200b-3p GPR158 -1.29 0.00027 2.24 0 TargetScan -0.47 0 NA
74 hsa-miR-200c-3p GPR158 -0.1 0.71696 2.24 0 miRNATAP -0.32 2.0E-5 NA
75 hsa-miR-200c-3p GPRASP2 -0.1 0.71696 -0.65 0 MirTarget -0.17 0 NA
76 hsa-miR-200b-3p GREM2 -1.29 0.00027 -3.65 0 TargetScan -0.33 1.0E-5 NA
77 hsa-miR-200b-3p HLF -1.29 0.00027 -1.56 0 MirTarget; TargetScan -0.18 0 NA
78 hsa-miR-200c-3p HLF -0.1 0.71696 -1.56 0 MirTarget; miRNATAP -0.34 0 NA
79 hsa-miR-200c-3p ICK -0.1 0.71696 0.39 0.01043 MirTarget; miRNATAP -0.1 6.0E-5 NA
80 hsa-miR-200a-3p IKBKG -1.5 3.0E-5 0.66 0 mirMAP -0.1 0 NA
81 hsa-miR-200a-3p IL6R -1.5 3.0E-5 -0.2 0.38255 MirTarget -0.16 0 NA
82 hsa-miR-200c-3p IMMP2L -0.1 0.71696 0.09 0.50196 MirTarget -0.19 0 NA
83 hsa-miR-200b-3p IRS1 -1.29 0.00027 -0.22 0.13754 TargetScan -0.14 0 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1
84 hsa-miR-200c-3p IRS1 -0.1 0.71696 -0.22 0.13754 miRNATAP -0.19 0 NA
85 hsa-miR-200b-3p ITPR2 -1.29 0.00027 -0.68 5.0E-5 MirTarget -0.13 0 NA
86 hsa-miR-200c-3p ITPR2 -0.1 0.71696 -0.68 5.0E-5 MirTarget -0.2 0 NA
87 hsa-miR-200b-3p JAKMIP2 -1.29 0.00027 -0.85 0.00348 TargetScan -0.22 0 NA
88 hsa-miR-200b-3p KCNB1 -1.29 0.00027 -1.36 0.00106 TargetScan -0.3 0 NA
89 hsa-miR-200c-3p KDR -0.1 0.71696 -0.81 1.0E-5 miRNATAP -0.12 0.00017 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
90 hsa-miR-200a-5p KLF9 -1.17 0.00105 -1.36 0 MirTarget; miRNATAP -0.17 0 NA
91 hsa-miR-200b-3p KLF9 -1.29 0.00027 -1.36 0 TargetScan -0.16 0 NA
92 hsa-miR-200c-3p KLF9 -0.1 0.71696 -1.36 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 0 NA
93 hsa-miR-200c-3p KLHDC1 -0.1 0.71696 -0.6 0.00069 MirTarget -0.11 0.00033 NA
94 hsa-miR-200b-3p LGSN -1.29 0.00027 -2.53 0 MirTarget -0.25 1.0E-5 NA
95 hsa-miR-200c-3p LGSN -0.1 0.71696 -2.53 0 MirTarget -0.34 0 NA
96 hsa-miR-200a-3p LIN28B -1.5 3.0E-5 2.27 5.0E-5 miRNATAP -0.26 0.00062 NA
97 hsa-miR-200a-3p LMLN -1.5 3.0E-5 -0.17 0.30156 mirMAP -0.1 0 NA
98 hsa-miR-200b-3p LPIN1 -1.29 0.00027 -0.14 0.37055 MirTarget; TargetScan -0.16 0 NA
99 hsa-miR-200b-3p LRP1B -1.29 0.00027 -1.67 0.0001 MirTarget; TargetScan -0.14 0.01404 NA
100 hsa-miR-200b-3p LRP4 -1.29 0.00027 0.52 0.07145 MirTarget; TargetScan -0.12 0.00239 NA
101 hsa-miR-200b-3p MAGEC2 -1.29 0.00027 3.47 0 MirTarget -0.59 0 NA
102 hsa-miR-200c-3p MAGEC2 -0.1 0.71696 3.47 0 MirTarget -0.28 0.0113 NA
103 hsa-miR-200a-3p MAP2 -1.5 3.0E-5 1.05 6.0E-5 miRNATAP -0.11 0.00265 NA
104 hsa-miR-200b-3p MAP2 -1.29 0.00027 1.05 6.0E-5 MirTarget; TargetScan -0.12 0.00064 NA
105 hsa-miR-200a-3p MFAP3L -1.5 3.0E-5 -3 0 MirTarget -0.26 0 NA
106 hsa-miR-200a-5p MFAP3L -1.17 0.00105 -3 0 MirTarget -0.3 0 NA
107 hsa-miR-200b-3p MOCS1 -1.29 0.00027 -0.56 3.0E-5 TargetScan -0.13 0 NA
108 hsa-miR-200b-3p MPDZ -1.29 0.00027 -1.66 0 MirTarget -0.23 0 NA
109 hsa-miR-200c-3p MPDZ -0.1 0.71696 -1.66 0 MirTarget -0.23 0 NA
110 hsa-miR-200a-3p MYRIP -1.5 3.0E-5 -1.63 2.0E-5 MirTarget -0.36 0 NA
111 hsa-miR-200c-3p NAP1L5 -0.1 0.71696 -1.3 0 MirTarget; miRNATAP -0.13 6.0E-5 NA
112 hsa-miR-200c-3p NDUFA5 -0.1 0.71696 -0.41 3.0E-5 mirMAP -0.11 0 NA
113 hsa-miR-200a-3p NFIA -1.5 3.0E-5 -0.92 0 miRNATAP -0.11 0 NA
114 hsa-miR-200a-5p NFIA -1.17 0.00105 -0.92 0 MirTarget; miRNATAP -0.12 0 NA
115 hsa-miR-200b-3p NFIA -1.29 0.00027 -0.92 0 MirTarget; TargetScan -0.11 0 NA
116 hsa-miR-200c-3p NFIA -0.1 0.71696 -0.92 0 MirTarget; miRNATAP -0.16 0 NA
117 hsa-miR-200b-3p NKD1 -1.29 0.00027 0.62 0.18603 TargetScan -0.18 0.00545 NA
118 hsa-miR-200b-3p NLGN4X -1.29 0.00027 -1.28 0.0004 TargetScan -0.12 0.01292 NA
119 hsa-miR-200c-3p NRG1 -0.1 0.71696 -3.96 0 miRNATAP -0.18 0.042 NA
120 hsa-miR-200a-3p NUDT12 -1.5 3.0E-5 -0.91 2.0E-5 MirTarget -0.14 0 NA
121 hsa-miR-200a-3p NUDT16 -1.5 3.0E-5 -0.31 0.00173 mirMAP -0.11 0 NA
122 hsa-miR-200b-3p ONECUT2 -1.29 0.00027 0.12 0.55138 TargetScan; mirMAP -0.11 8.0E-5 NA
123 hsa-miR-200c-3p ONECUT2 -0.1 0.71696 0.12 0.55138 mirMAP -0.11 0.00202 NA
124 hsa-miR-200b-3p PALM2 -1.29 0.00027 -2.08 0 TargetScan -0.14 1.0E-5 NA
125 hsa-miR-200a-5p PDE4DIP -1.17 0.00105 -0.27 0.06042 mirMAP -0.11 0 NA
126 hsa-miR-200b-3p PI4K2B -1.29 0.00027 -0.76 0 MirTarget; TargetScan -0.11 0 NA
127 hsa-miR-200c-3p PI4K2B -0.1 0.71696 -0.76 0 MirTarget -0.14 0 NA
128 hsa-miR-200c-3p PIK3R1 -0.1 0.71696 -0.89 0 mirMAP -0.11 9.0E-5 NA
129 hsa-miR-200b-3p PPARA -1.29 0.00027 -0.61 3.0E-5 MirTarget -0.13 0 NA
130 hsa-miR-200c-3p PPARA -0.1 0.71696 -0.61 3.0E-5 MirTarget -0.13 0 NA
131 hsa-miR-200c-3p PPARGC1A -0.1 0.71696 -1.91 0 mirMAP -0.2 0.0005 NA
132 hsa-miR-200a-3p PPARGC1B -1.5 3.0E-5 -0.17 0.38345 mirMAP -0.15 0 NA
133 hsa-miR-200a-5p PPARGC1B -1.17 0.00105 -0.17 0.38345 mirMAP -0.14 0 NA
134 hsa-miR-200b-3p PPARGC1B -1.29 0.00027 -0.17 0.38345 mirMAP -0.15 0 NA
135 hsa-miR-200c-3p PPARGC1B -0.1 0.71696 -0.17 0.38345 mirMAP -0.11 0.00145 NA
136 hsa-miR-200a-3p PPM1E -1.5 3.0E-5 -0.36 0.29679 MirTarget; miRNATAP -0.14 0.00231 NA
137 hsa-miR-200a-5p PPM1E -1.17 0.00105 -0.36 0.29679 MirTarget -0.16 0.00061 NA
138 hsa-miR-200b-3p PPM1E -1.29 0.00027 -0.36 0.29679 MirTarget -0.17 0.0003 NA
139 hsa-miR-200a-3p PPM1L -1.5 3.0E-5 -0.36 0.07741 MirTarget -0.12 2.0E-5 NA
140 hsa-miR-200b-3p PSD3 -1.29 0.00027 -1.2 0 MirTarget; mirMAP -0.1 0.00025 NA
141 hsa-miR-200c-3p PSD3 -0.1 0.71696 -1.2 0 MirTarget; mirMAP; miRNATAP -0.1 0.00285 NA
142 hsa-miR-200a-3p RAB3C -1.5 3.0E-5 0.18 0.69641 mirMAP -0.16 0.0096 NA
143 hsa-miR-200c-3p RANBP10 -0.1 0.71696 -0.16 0.14265 MirTarget; miRNATAP -0.14 0 NA
144 hsa-miR-200b-3p RBM20 -1.29 0.00027 0.81 0.00223 MirTarget; TargetScan -0.14 6.0E-5 NA
145 hsa-miR-200b-3p RNASEL -1.29 0.00027 -0.3 0.08846 MirTarget -0.13 0 NA
146 hsa-miR-200c-3p RNASEL -0.1 0.71696 -0.3 0.08846 MirTarget -0.12 3.0E-5 NA
147 hsa-miR-200a-3p RNF217 -1.5 3.0E-5 -0.87 3.0E-5 mirMAP -0.16 0 NA
148 hsa-miR-200a-5p RNF217 -1.17 0.00105 -0.87 3.0E-5 mirMAP -0.16 0 NA
149 hsa-miR-200a-5p RORA -1.17 0.00105 -1.19 0 MirTarget; miRNATAP -0.1 3.0E-5 NA
150 hsa-miR-200a-3p RSPO2 -1.5 3.0E-5 -1.48 0.00047 MirTarget -0.14 0.0165 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 ORGANIC ANION TRANSPORT 17 387 1.205e-08 5.606e-05
2 REGULATION OF LIPID METABOLIC PROCESS 14 282 5.559e-08 0.0001293
3 ANION TRANSPORT 18 507 1.125e-07 0.0001745
4 REGULATION OF HORMONE LEVELS 17 478 2.53e-07 0.0002943
5 ORGANIC ACID TRANSPORT 12 261 1.156e-06 0.001076
6 FLAVONOID METABOLIC PROCESS 5 28 2.451e-06 0.0019
7 ANION TRANSMEMBRANE TRANSPORT 11 251 5.184e-06 0.003329
8 ORGANIC ACID METABOLIC PROCESS 22 953 6.134e-06 0.003329
9 AMINO ACID TRANSPORT 8 124 6.44e-06 0.003329
10 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 9 172 9.35e-06 0.004172
11 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 34 1977 1.026e-05 0.004172
12 CELLULAR LIPID METABOLIC PROCESS 21 913 1.076e-05 0.004172
13 AMINO ACID TRANSMEMBRANE TRANSPORT 6 67 1.482e-05 0.005304
14 ION TRANSPORT 25 1262 1.9e-05 0.005526
15 SMALL MOLECULE METABOLIC PROCESS 31 1767 1.866e-05 0.005526
16 ORGANIC ACID TRANSMEMBRANE TRANSPORT 7 103 1.765e-05 0.005526
17 SINGLE ORGANISM CATABOLIC PROCESS 21 957 2.172e-05 0.005944
18 CELLULAR GLUCURONIDATION 4 22 2.455e-05 0.006346
19 LIPID HOMEOSTASIS 7 110 2.707e-05 0.006371
20 ION TRANSMEMBRANE TRANSPORT 19 822 2.738e-05 0.006371
21 MODIFIED AMINO ACID TRANSPORT 4 26 4.895e-05 0.009903
22 MONOCARBOXYLIC ACID METABOLIC PROCESS 14 503 4.747e-05 0.009903
23 HORMONE METABOLIC PROCESS 8 164 4.893e-05 0.009903
NumGOOverlapSizeP ValueAdj. P Value
1 ORGANIC ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 13 178 1.706e-09 1.585e-06
2 ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 14 293 8.928e-08 4.147e-05
3 ORGANIC ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 10 142 1.934e-07 5.99e-05
4 AMINO ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 7 79 3.025e-06 0.000562
5 SECONDARY ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 11 233 2.537e-06 0.000562
6 PROTEIN TYROSINE KINASE BINDING 6 54 4.173e-06 0.0006462
7 MODIFIED AMINO ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 4 16 6.338e-06 0.0008411
8 SYMPORTER ACTIVITY 8 142 1.741e-05 0.002021
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00514_Other_types_of_O.glycan_biosynthesis 5 46 3.048e-05 0.00401
2 hsa00053_Ascorbate_and_aldarate_metabolism 4 26 4.895e-05 0.00401
3 hsa00500_Starch_and_sucrose_metabolism 5 54 6.683e-05 0.00401
4 hsa00040_Pentose_and_glucuronate_interconversions 4 32 0.0001135 0.005107
5 hsa04920_Adipocytokine_signaling_pathway 5 68 0.0002016 0.007256
6 hsa00860_Porphyrin_and_chlorophyll_metabolism 4 43 0.000364 0.01092
7 hsa00983_Drug_metabolism_._other_enzymes 4 52 0.0007558 0.01943
8 hsa00140_Steroid_hormone_biosynthesis 4 57 0.00107 0.02407
9 hsa00830_Retinol_metabolism 4 64 0.001648 0.03297
10 hsa04151_PI3K_AKT_signaling_pathway 9 351 0.00194 0.03319
11 hsa00250_Alanine._aspartate_and_glutamate_metabolism 3 32 0.002028 0.03319
12 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 4 71 0.002416 0.03623
13 hsa00982_Drug_metabolism_._cytochrome_P450 4 73 0.002673 0.03701
14 hsa04614_Renin.angiotensin_system 2 17 0.007803 0.1003
15 hsa04115_p53_signaling_pathway 3 69 0.01733 0.208
16 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.02391 0.2541
17 hsa04910_Insulin_signaling_pathway 4 138 0.024 0.2541
18 hsa04974_Protein_digestion_and_absorption 3 81 0.02636 0.2636
19 hsa00270_Cysteine_and_methionine_metabolism 2 36 0.03278 0.3106
20 hsa04014_Ras_signaling_pathway 5 236 0.03961 0.3395
21 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.04346 0.3545
22 hsa00280_Valine._leucine_and_isoleucine_degradation 2 44 0.04726 0.3545
23 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.04726 0.3545
24 hsa00330_Arginine_and_proline_metabolism 2 54 0.06797 0.4894
25 hsa04722_Neurotrophin_signaling_pathway 3 127 0.07959 0.521
26 hsa04380_Osteoclast_differentiation 3 128 0.08105 0.521
27 hsa04810_Regulation_of_actin_cytoskeleton 4 214 0.08996 0.5584
28 hsa04514_Cell_adhesion_molecules_.CAMs. 3 136 0.09313 0.5588
29 hsa04610_Complement_and_coagulation_cascades 2 69 0.1033 0.5811
30 hsa03320_PPAR_signaling_pathway 2 70 0.1059 0.5811
31 hsa04976_Bile_secretion 2 71 0.1084 0.5811
32 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.1186 0.5811
33 hsa04370_VEGF_signaling_pathway 2 76 0.1213 0.5811
34 hsa04390_Hippo_signaling_pathway 3 154 0.1228 0.5811
35 hsa04146_Peroxisome 2 79 0.1291 0.5811
36 hsa04141_Protein_processing_in_endoplasmic_reticulum 3 168 0.1479 0.6121
37 hsa04012_ErbB_signaling_pathway 2 87 0.1507 0.6121
38 hsa04210_Apoptosis 2 89 0.1562 0.6121
39 hsa04010_MAPK_signaling_pathway 4 268 0.1628 0.6121
40 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.173 0.6121
41 hsa04972_Pancreatic_secretion 2 101 0.19 0.6313
42 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.1928 0.6313
43 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.2101 0.6691
44 hsa04114_Oocyte_meiosis 2 114 0.2275 0.694
45 hsa04110_Cell_cycle 2 128 0.2684 0.8051
46 hsa04630_Jak.STAT_signaling_pathway 2 155 0.3468 0.9048
47 hsa04062_Chemokine_signaling_pathway 2 189 0.4413 0.9879
48 hsa04510_Focal_adhesion 2 200 0.4703 1
49 hsa04144_Endocytosis 2 203 0.478 1

Quest ID: 798b9adfe8c5a48843ed7eb81fd6cd7f