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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-142-3p BUB1B -1.42 0 3.86 0 miRanda -0.2 0.01193 NA
2 hsa-miR-192-5p BUB1B -0.5 0.00345 3.86 0 miRNAWalker2 validate -0.22 0.01192 NA
3 hsa-miR-193b-3p BUB1B -0.17 0.27202 3.86 0 miRNAWalker2 validate -0.2 0.04744 NA
4 hsa-miR-215-5p BUB1B -0.98 3.0E-5 3.86 0 miRNAWalker2 validate -0.16 0.00993 NA
5 hsa-miR-22-3p BUB1B -0.63 0 3.86 0 miRNAWalker2 validate -1.6 0 NA
6 hsa-miR-486-5p BUB1B -1.78 0 3.86 0 miRanda -0.42 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF LIGASE ACTIVITY 13 110 1.331e-16 6.193e-13
2 REGULATION OF LIGASE ACTIVITY 13 130 1.242e-15 2.889e-12
3 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 103 2.551e-15 3.956e-12
4 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 14 192 7.886e-15 9.174e-12
5 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 196 1.052e-14 9.786e-12
6 CELL CYCLE PROCESS 25 1081 3.049e-14 2.364e-11
7 CELL CYCLE 27 1316 3.746e-14 2.49e-11
8 POSITIVE REGULATION OF CATABOLIC PROCESS 17 395 4.842e-14 2.816e-11
9 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 15 274 5.475e-14 2.831e-11
10 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 10 77 1.997e-13 8.7e-11
11 POSITIVE REGULATION OF PROTEOLYSIS 16 363 2.057e-13 8.7e-11
12 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 14 263 6.057e-13 2.168e-10
13 REGULATION OF PROTEOLYSIS 20 711 5.846e-13 2.168e-10
14 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 24 1135 7.981e-13 2.653e-10
15 POSITIVE REGULATION OF CATALYTIC ACTIVITY 27 1518 1.136e-12 3.525e-10
16 POSITIVE REGULATION OF MOLECULAR FUNCTION 29 1791 1.253e-12 3.644e-10
17 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 280 1.419e-12 3.884e-10
18 MITOTIC CELL CYCLE 20 766 2.292e-12 5.925e-10
19 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 18 616 5.525e-12 1.285e-09
20 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 26 1492 5.512e-12 1.285e-09
21 REGULATION OF CELL CYCLE PHASE TRANSITION 14 321 8.95e-12 1.983e-09
22 REGULATION OF PROTEIN CATABOLIC PROCESS 15 393 9.944e-12 2.103e-09
23 NIK NF KAPPAB SIGNALING 9 83 1.83e-11 3.702e-09
24 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 14 351 2.948e-11 5.716e-09
25 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 616 5.773e-11 1.075e-08
26 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 10 139 8.115e-11 1.452e-08
27 REGULATION OF TRANSFERASE ACTIVITY 20 946 1.022e-10 1.761e-08
28 REGULATION OF PROTEIN MODIFICATION PROCESS 26 1710 1.155e-10 1.861e-08
29 REGULATION OF MITOTIC CELL CYCLE 15 468 1.16e-10 1.861e-08
30 T CELL RECEPTOR SIGNALING PATHWAY 10 146 1.321e-10 2.007e-08
31 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 11 197 1.337e-10 2.007e-08
32 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 21 1087 1.646e-10 2.393e-08
33 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 9 106 1.711e-10 2.412e-08
34 PROTEASOMAL PROTEIN CATABOLIC PROCESS 12 271 2.651e-10 3.628e-08
35 REGULATION OF CATABOLIC PROCESS 17 731 8.03e-10 1.068e-07
36 REGULATION OF RESPONSE TO STRESS 23 1468 1.096e-09 1.417e-07
37 PROTEIN POLYUBIQUITINATION 11 243 1.245e-09 1.566e-07
38 REGULATION OF RNA STABILITY 9 139 1.94e-09 2.376e-07
39 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 10 195 2.246e-09 2.68e-07
40 FC EPSILON RECEPTOR SIGNALING PATHWAY 9 142 2.344e-09 2.727e-07
41 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 19 1021 2.769e-09 3.143e-07
42 WNT SIGNALING PATHWAY 12 351 4.981e-09 5.518e-07
43 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 8 110 6.465e-09 6.996e-07
44 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 162 7.483e-09 7.913e-07
45 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 8 118 1.128e-08 1.166e-06
46 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 8 119 1.206e-08 1.194e-06
47 REGULATION OF CELL CYCLE PROCESS 14 558 1.2e-08 1.194e-06
48 REGULATION OF WNT SIGNALING PATHWAY 11 310 1.574e-08 1.526e-06
49 REGULATION OF CELLULAR AMINE METABOLIC PROCESS 7 88 3.226e-08 3.063e-06
50 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 16 829 3.785e-08 3.522e-06
51 REGULATION OF CELL CYCLE 17 949 3.904e-08 3.562e-06
52 NON CANONICAL WNT SIGNALING PATHWAY 8 140 4.319e-08 3.722e-06
53 NEGATIVE REGULATION OF MOLECULAR FUNCTION 18 1079 4.252e-08 3.722e-06
54 PROTEOLYSIS 19 1208 4.2e-08 3.722e-06
55 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 20 1360 5.157e-08 4.363e-06
56 PROTEIN UBIQUITINATION 14 629 5.354e-08 4.448e-06
57 ACTIVATION OF INNATE IMMUNE RESPONSE 9 204 5.532e-08 4.516e-06
58 FC RECEPTOR SIGNALING PATHWAY 9 206 6.015e-08 4.826e-06
59 REGULATION OF INNATE IMMUNE RESPONSE 11 357 6.656e-08 5.249e-06
60 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 16 873 7.72e-08 5.987e-06
61 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 8 152 8.187e-08 6.245e-06
62 ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I 6 66 1.465e-07 1.082e-05
63 REGULATION OF CELLULAR AMINO ACID METABOLIC PROCESS 6 66 1.465e-07 1.082e-05
64 PROTEIN CATABOLIC PROCESS 13 579 1.541e-07 1.12e-05
65 POSITIVE REGULATION OF RESPONSE TO STIMULUS 23 1929 1.853e-07 1.327e-05
66 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 236 1.918e-07 1.332e-05
67 NEGATIVE REGULATION OF CELL COMMUNICATION 18 1192 1.902e-07 1.332e-05
68 ORGANELLE FISSION 12 496 2.208e-07 1.511e-05
69 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 11 404 2.308e-07 1.557e-05
70 REGULATION OF ORGAN MORPHOGENESIS 9 242 2.372e-07 1.577e-05
71 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 10 323 2.652e-07 1.738e-05
72 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 9 246 2.724e-07 1.761e-05
73 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 8 181 3.137e-07 2e-05
74 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 11 448 6.429e-07 4.042e-05
75 CYTOKINE MEDIATED SIGNALING PATHWAY 11 452 7.016e-07 4.353e-05
76 POSITIVE REGULATION OF DEFENSE RESPONSE 10 364 7.909e-07 4.842e-05
77 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I 6 91 1.001e-06 6.046e-05
78 PROTEIN PHOSPHORYLATION 15 944 1.282e-06 7.65e-05
79 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 20 1672 1.422e-06 8.377e-05
80 POSITIVE REGULATION OF CELL COMMUNICATION 19 1532 1.64e-06 9.539e-05
81 RESPONSE TO TUMOR NECROSIS FACTOR 8 233 2.108e-06 0.0001211
82 REGULATION OF IMMUNE RESPONSE 14 858 2.251e-06 0.0001277
83 REGULATION OF DEFENSE RESPONSE 13 759 3.218e-06 0.0001791
84 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 7 173 3.234e-06 0.0001791
85 ACTIVATION OF IMMUNE RESPONSE 10 427 3.314e-06 0.0001814
86 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN 7 177 3.762e-06 0.0002035
87 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 21 1977 4.834e-06 0.0002585
88 POSITIVE REGULATION OF IMMUNE RESPONSE 11 563 5.846e-06 0.0003091
89 CELL DIVISION 10 460 6.391e-06 0.0003341
90 MITOTIC NUCLEAR DIVISION 9 361 6.462e-06 0.0003341
91 CELLULAR RESPONSE TO STRESS 18 1565 9.434e-06 0.0004824
92 INTRACELLULAR SIGNAL TRANSDUCTION 18 1572 1.003e-05 0.0005073
93 CELLULAR RESPONSE TO CYTOKINE STIMULUS 11 606 1.168e-05 0.0005846
94 ANTIGEN PROCESSING AND PRESENTATION 7 213 1.265e-05 0.000626
95 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 13 867 1.35e-05 0.000661
96 CHROMOSOME ORGANIZATION 14 1009 1.441e-05 0.0006982
97 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 6 146 1.554e-05 0.0007454
98 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 6 147 1.615e-05 0.000767
99 CELLULAR CATABOLIC PROCESS 16 1322 1.764e-05 0.0008289
100 IMMUNE SYSTEM PROCESS 20 1984 1.895e-05 0.0008815
101 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 7 232 2.195e-05 0.001011
102 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 19 1848 2.473e-05 0.001128
103 INTERSPECIES INTERACTION BETWEEN ORGANISMS 11 662 2.648e-05 0.001185
104 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 11 662 2.648e-05 0.001185
105 MACROMOLECULE CATABOLIC PROCESS 13 926 2.698e-05 0.001195
106 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 97 2.799e-05 0.001228
107 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 98 2.941e-05 0.001279
108 PHOSPHORYLATION 15 1228 3.048e-05 0.001313
109 REGULATION OF CELL PROJECTION ORGANIZATION 10 558 3.378e-05 0.001442
110 REGULATION OF IMMUNE SYSTEM PROCESS 16 1403 3.653e-05 0.001545
111 CELL CYCLE PHASE TRANSITION 7 255 4.014e-05 0.001683
112 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 4 54 4.499e-05 0.001869
113 CATABOLIC PROCESS 18 1773 5.055e-05 0.002081
114 REGULATION OF DENDRITIC SPINE DEVELOPMENT 4 56 5.197e-05 0.002103
115 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 470 5.183e-05 0.002103
116 RESPONSE TO CYTOKINE 11 714 5.267e-05 0.002113
117 CYTOSKELETON DEPENDENT INTRACELLULAR TRANSPORT 5 116 6.601e-05 0.002625
118 REGULATION OF HYDROLASE ACTIVITY 15 1327 7.408e-05 0.002921
119 CELL CYCLE CHECKPOINT 6 194 7.65e-05 0.002991
120 REGULATION OF DENDRITE DEVELOPMENT 5 120 7.755e-05 0.003007
121 CARBOHYDRATE BIOSYNTHETIC PROCESS 5 121 8.067e-05 0.003102
122 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 13 1036 8.54e-05 0.003231
123 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 1036 8.54e-05 0.003231
124 POSITIVE REGULATION OF DENDRITE DEVELOPMENT 4 64 8.794e-05 0.003259
125 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 8.825e-05 0.003259
126 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 6 199 8.802e-05 0.003259
127 GLYCOGEN BIOSYNTHETIC PROCESS 3 25 0.0001013 0.003682
128 GLUCAN BIOSYNTHETIC PROCESS 3 25 0.0001013 0.003682
129 REGULATION OF KINASE ACTIVITY 11 776 0.0001107 0.003993
130 REGULATION OF NEURON PROJECTION DEVELOPMENT 8 408 0.0001182 0.004206
131 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 7 303 0.0001184 0.004206
132 POSITIVE REGULATION OF NEURON DIFFERENTIATION 7 306 0.0001259 0.004437
133 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 3 27 0.0001281 0.004483
134 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 134 0.0001306 0.004486
135 POSITIVE REGULATION OF GENE EXPRESSION 17 1733 0.000131 0.004486
136 NEGATIVE REGULATION OF CELL CYCLE PROCESS 6 214 0.0001311 0.004486
137 REGULATION OF MAPK CASCADE 10 660 0.0001364 0.004632
138 G1 DNA DAMAGE CHECKPOINT 4 73 0.000147 0.004955
139 CELL CYCLE G2 M PHASE TRANSITION 5 138 0.0001499 0.005018
140 REGULATION OF DENDRITE MORPHOGENESIS 4 74 0.0001549 0.005117
141 MITOTIC CELL CYCLE CHECKPOINT 5 139 0.0001551 0.005117
142 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 3 30 0.0001765 0.005742
143 REGULATION OF CELL MORPHOGENESIS 9 552 0.0001757 0.005742
144 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 5 144 0.0001829 0.00591
145 DNA INTEGRITY CHECKPOINT 5 146 0.0001951 0.006259
146 REGULATION OF PHOSPHORUS METABOLIC PROCESS 16 1618 0.0001966 0.006267
147 POSITIVE REGULATION OF CELL CYCLE 7 332 0.0002078 0.006577
148 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 3 32 0.0002144 0.006697
149 POSITIVE REGULATION OF DENDRITE MORPHOGENESIS 3 32 0.0002144 0.006697
150 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 0.0002352 0.00725
151 NEGATIVE REGULATION OF JNK CASCADE 3 33 0.0002353 0.00725
152 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 13 1152 0.0002449 0.007496
153 MICROTUBULE ORGANIZING CENTER ORGANIZATION 4 84 0.0002528 0.007687
154 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 10 720 0.0002751 0.008311
155 POSITIVE REGULATION OF DENDRITIC SPINE DEVELOPMENT 3 35 0.0002808 0.008428
156 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 3 36 0.0003055 0.009112
157 COGNITION 6 251 0.0003103 0.009196
158 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 11 876 0.0003169 0.009332
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEASOME COMPLEX 6 76 3.426e-07 0.000126
2 NUCLEAR UBIQUITIN LIGASE COMPLEX 5 42 4.316e-07 0.000126
3 KINESIN COMPLEX 5 55 1.701e-06 0.0003312
4 UBIQUITIN LIGASE COMPLEX 8 262 5.022e-06 0.0007332
5 CHROMOSOME 13 880 1.58e-05 0.001845
6 CHROMOSOME CENTROMERIC REGION 6 174 4.179e-05 0.004068
7 PROTEASOME CORE COMPLEX 3 20 5.086e-05 0.004243
8 ANAPHASE PROMOTING COMPLEX 3 22 6.835e-05 0.004435
9 MITOCHONDRION 17 1633 6.294e-05 0.004435
10 KINETOCHORE 5 120 7.755e-05 0.004529
11 PROTEASOME ACCESSORY COMPLEX 3 24 8.936e-05 0.004744
12 CHROMOSOMAL REGION 7 330 0.0002003 0.008847
13 TRANSFERASE COMPLEX 10 703 0.0002272 0.008847
14 MICROTUBULE ASSOCIATED COMPLEX 5 145 0.0001889 0.008847
15 CULLIN RING UBIQUITIN LIGASE COMPLEX 5 150 0.0002212 0.008847

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Oocyte_meiosis_hsa04114 6 124 6.097e-06 0.0003171
2 Cell_cycle_hsa04110 5 124 9.059e-05 0.00162
3 Mitophagy_animal_hsa04137 4 65 9.345e-05 0.00162
4 p53_signaling_pathway_hsa04115 3 68 0.001972 0.02564
5 Cellular_senescence_hsa04218 4 160 0.002797 0.02909
6 FoxO_signaling_pathway_hsa04068 3 132 0.01249 0.1083
7 Wnt_signaling_pathway_hsa04310 3 146 0.01634 0.1214
8 Apelin_signaling_pathway_hsa04371 2 137 0.08941 0.5812
9 Focal_adhesion_hsa04510 2 199 0.1643 0.7769
10 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.2697 0.8326
11 MAPK_signaling_pathway_hsa04010 2 295 0.2927 0.8326
12 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.3689 0.8326

Quest ID: 7b02a590453db1836f2d0ceb1db8713f