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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-103a-3p CD274 -0.31 0.76908 0.44 0.09392 miRNAWalker2 validate -0.55 1.0E-5 NA
2 hsa-miR-106b-5p CD274 -0.4 0.51813 0.44 0.09392 MirTarget; miRNATAP -0.33 0.0004 NA
3 hsa-miR-139-5p CD274 0.04 0.92275 0.44 0.09392 miRanda -0.31 0.00052 NA
4 hsa-miR-141-3p CD274 -0.99 0.17779 0.44 0.09392 MirTarget -0.22 0 NA
5 hsa-miR-182-5p CD274 -0.59 0.55947 0.44 0.09392 mirMAP -0.32 0 NA
6 hsa-miR-200a-3p CD274 -1.02 0.11183 0.44 0.09392 MirTarget -0.32 0 NA
7 hsa-miR-20b-5p CD274 -0.45 0.21774 0.44 0.09392 MirTarget; miRNATAP -0.14 0.00613 24468585 These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer
8 hsa-miR-224-3p CD274 -0.41 0.11976 0.44 0.09392 MirTarget -0.14 0.00867 NA
9 hsa-miR-320a CD274 -0.18 0.78959 0.44 0.09392 MirTarget -0.65 0 NA
10 hsa-miR-320b CD274 -0.37 0.06277 0.44 0.09392 MirTarget -0.22 0.01248 NA
11 hsa-miR-324-5p CD274 -0.56 0.12389 0.44 0.09392 miRanda -0.15 0.04356 NA
12 hsa-miR-378a-3p CD274 -0.66 0.32117 0.44 0.09392 MirTarget -0.53 0 NA
13 hsa-miR-378c CD274 -0.48 0.04341 0.44 0.09392 MirTarget -0.2 0.03268 NA
14 hsa-miR-429 CD274 -0.95 0.10836 0.44 0.09392 miRanda -0.34 0 NA
15 hsa-miR-450b-5p CD274 0.09 0.74933 0.44 0.09392 mirMAP -0.19 0.03632 NA
16 hsa-miR-497-5p CD274 0.14 0.61973 0.44 0.09392 MirTarget -0.25 0.01134 NA
17 hsa-miR-664a-3p CD274 -0.53 0.13578 0.44 0.09392 mirMAP -0.73 0 NA
18 hsa-miR-93-5p CD274 -0.53 0.57056 0.44 0.09392 MirTarget; miRNATAP -0.37 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL PROLIFERATION 16 1496 2.368e-11 1.102e-07
2 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 10 689 2.442e-08 2.841e-05
3 REGULATION OF PROTEIN KINASE B SIGNALING 6 121 1.835e-08 2.841e-05
4 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 9 498 2.201e-08 2.841e-05
5 RESPONSE TO ENDOGENOUS STIMULUS 13 1450 3.277e-08 3.049e-05
6 REGULATION OF TRANSFERASE ACTIVITY 11 946 3.95e-08 3.058e-05
7 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 13 1492 4.601e-08 3.058e-05
8 REGULATION OF KINASE ACTIVITY 10 776 7.479e-08 3.196e-05
9 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 14 1848 6.426e-08 3.196e-05
10 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 11 1008 7.556e-08 3.196e-05
11 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 7.039e-08 3.196e-05
12 REGULATION OF GROWTH 9 633 1.71e-07 5.858e-05
13 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 13 1672 1.762e-07 5.858e-05
14 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 12 1360 1.631e-07 5.858e-05
15 NEGATIVE REGULATION OF CELL PROLIFERATION 9 643 1.953e-07 6.059e-05
16 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 2.953e-07 6.245e-05
17 RESPONSE TO HORMONE 10 893 2.765e-07 6.245e-05
18 PEPTIDYL TYROSINE MODIFICATION 6 186 2.373e-07 6.245e-05
19 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 11 1135 2.514e-07 6.245e-05
20 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 11 1142 2.674e-07 6.245e-05
21 REGULATION OF PROTEIN MODIFICATION PROCESS 13 1710 2.292e-07 6.245e-05
22 PROTEIN AUTOPHOSPHORYLATION 6 192 2.861e-07 6.245e-05
23 RESPONSE TO STEROID HORMONE 8 497 3.727e-07 7.539e-05
24 NEGATIVE REGULATION OF CELL COMMUNICATION 11 1192 4.111e-07 7.971e-05
25 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 750 7.128e-07 0.0001276
26 NEGATIVE REGULATION OF CELL ADHESION 6 223 6.887e-07 0.0001276
27 NEGATIVE REGULATION OF GROWTH 6 236 9.588e-07 0.0001538
28 REGULATION OF CELL CELL ADHESION 7 380 9.206e-07 0.0001538
29 REPRODUCTION 11 1297 9.535e-07 0.0001538
30 REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 1618 1.065e-06 0.0001652
31 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 1656 1.364e-06 0.0002048
32 POSITIVE REGULATION OF CELL PROLIFERATION 9 814 1.409e-06 0.0002049
33 REGULATION OF CELL DEVELOPMENT 9 836 1.757e-06 0.0002478
34 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 8 616 1.874e-06 0.0002491
35 RESPONSE TO MANGANESE ION 3 17 1.839e-06 0.0002491
36 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 1395 1.957e-06 0.0002529
37 NEUROGENESIS 11 1402 2.055e-06 0.0002584
38 REGULATION OF CELL ADHESION 8 629 2.189e-06 0.0002681
39 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 437 2.333e-06 0.0002784
40 RESPONSE TO EXTRACELLULAR STIMULUS 7 441 2.478e-06 0.0002883
41 REGULATION OF LIPID METABOLIC PROCESS 6 282 2.695e-06 0.0003058
42 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 1152 2.828e-06 0.0003134
43 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 3.104e-06 0.0003359
44 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 3.326e-06 0.0003439
45 REGULATION OF CELL DEATH 11 1472 3.31e-06 0.0003439
46 RESPONSE TO EXTERNAL STIMULUS 12 1821 3.723e-06 0.0003584
47 RESPONSE TO ORGANIC CYCLIC COMPOUND 9 917 3.761e-06 0.0003584
48 REGULATION OF CELL DIFFERENTIATION 11 1492 3.775e-06 0.0003584
49 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 470 3.774e-06 0.0003584
50 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 3.881e-06 0.0003612
51 RESPONSE TO GROWTH FACTOR 7 475 4.046e-06 0.0003692
52 REGULATION OF HOMOTYPIC CELL CELL ADHESION 6 307 4.395e-06 0.0003933
53 ERBB SIGNALING PATHWAY 4 79 4.967e-06 0.0004361
54 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 5.489e-06 0.000473
55 CELLULAR RESPONSE TO NITROGEN COMPOUND 7 505 6.049e-06 0.0005117
56 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 6.628e-06 0.0005507
57 RESPONSE TO NUTRIENT 5 191 7.431e-06 0.0006066
58 CELL DEATH 9 1001 7.679e-06 0.000616
59 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 9 1021 9.012e-06 0.0007107
60 REGULATION OF HYDROLASE ACTIVITY 10 1327 9.979e-06 0.0007608
61 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 9 1036 1.014e-05 0.0007608
62 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 9 1036 1.014e-05 0.0007608
63 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 1.072e-05 0.0007738
64 HOMEOSTATIC PROCESS 10 1337 1.066e-05 0.0007738
65 CELLULAR RESPONSE TO HORMONE STIMULUS 7 552 1.081e-05 0.0007738
66 LIPID MODIFICATION 5 210 1.177e-05 0.0008298
67 REGULATION OF CYTOKINE PRODUCTION 7 563 1.229e-05 0.0008533
68 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 3 32 1.322e-05 0.0008541
69 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 8 799 1.274e-05 0.0008541
70 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 1.261e-05 0.0008541
71 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 8 801 1.297e-05 0.0008541
72 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 6 372 1.315e-05 0.0008541
73 RESPONSE TO ESTROGEN 5 218 1.41e-05 0.0008988
74 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1087 1.492e-05 0.0009382
75 REGULATION OF GLUCOSE METABOLIC PROCESS 4 106 1.599e-05 0.0009787
76 POSITIVE REGULATION OF CELL DIFFERENTIATION 8 823 1.579e-05 0.0009787
77 REGULATION OF IMMUNE SYSTEM PROCESS 10 1403 1.628e-05 0.0009839
78 REGULATION OF CELL GROWTH 6 391 1.744e-05 0.00104
79 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 3 36 1.895e-05 0.001116
80 PROTEIN COMPLEX BIOGENESIS 9 1132 2.063e-05 0.001185
81 PROTEIN COMPLEX ASSEMBLY 9 1132 2.063e-05 0.001185
82 RESPONSE TO NITROGEN COMPOUND 8 859 2.151e-05 0.001205
83 REGULATION OF IMMUNE RESPONSE 8 858 2.133e-05 0.001205
84 POSITIVE REGULATION OF MOLECULAR FUNCTION 11 1791 2.176e-05 0.001205
85 ERBB2 SIGNALING PATHWAY 3 39 2.419e-05 0.001309
86 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 2.419e-05 0.001309
87 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 2.477e-05 0.001325
88 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 2.612e-05 0.001366
89 POSITIVE REGULATION OF LOCOMOTION 6 420 2.61e-05 0.001366
90 NEGATIVE REGULATION OF IMMUNE RESPONSE 4 121 2.693e-05 0.001392
91 RESPONSE TO LIPID 8 888 2.732e-05 0.001397
92 MULTI ORGANISM REPRODUCTIVE PROCESS 8 891 2.798e-05 0.001415
93 POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 42 3.029e-05 0.001499
94 RESPONSE TO DRUG 6 431 3.017e-05 0.001499
95 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 6 437 3.26e-05 0.00158
96 POSITIVE REGULATION OF CATALYTIC ACTIVITY 10 1518 3.23e-05 0.00158
97 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 4 128 3.358e-05 0.001611
98 MYELOID CELL DEVELOPMENT 3 44 3.488e-05 0.001656
99 POSITIVE REGULATION OF TRANSPORT 8 936 3.981e-05 0.001871
100 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 4 136 4.258e-05 0.001942
101 PROTEIN PHOSPHORYLATION 8 944 4.23e-05 0.001942
102 CELLULAR RESPONSE TO PEPTIDE 5 274 4.221e-05 0.001942
103 POSITIVE REGULATION OF RESPONSE TO STIMULUS 11 1929 4.363e-05 0.001953
104 INTRACELLULAR SIGNAL TRANSDUCTION 10 1572 4.365e-05 0.001953
105 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 4.507e-05 0.001973
106 NEGATIVE REGULATION OF CELL CELL ADHESION 4 138 4.507e-05 0.001973
107 REGULATION OF LIPID KINASE ACTIVITY 3 48 4.537e-05 0.001973
108 HEART DEVELOPMENT 6 466 4.667e-05 0.002011
109 REGULATION OF PROTEOLYSIS 7 711 5.487e-05 0.002342
110 REGULATION OF CELL ACTIVATION 6 484 5.761e-05 0.002354
111 RESPONSE TO ESTRADIOL 4 146 5.616e-05 0.002354
112 LEUKOCYTE DIFFERENTIATION 5 292 5.711e-05 0.002354
113 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 5.616e-05 0.002354
114 REGULATION OF T CELL PROLIFERATION 4 147 5.767e-05 0.002354
115 SEXUAL REPRODUCTION 7 730 6.482e-05 0.0026
116 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 6.469e-05 0.0026
117 REGULATION OF CATABOLIC PROCESS 7 731 6.539e-05 0.0026
118 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 6.804e-05 0.002683
119 POSITIVE REGULATION OF CELL ACTIVATION 5 311 7.695e-05 0.003009
120 BEHAVIOR 6 516 8.21e-05 0.003183
121 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 9.322e-05 0.003585
122 RESPONSE TO OXYGEN CONTAINING COMPOUND 9 1381 9.826e-05 0.003717
123 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 62 9.787e-05 0.003717
124 POSITIVE REGULATION OF GENE EXPRESSION 10 1733 0.0001001 0.003754
125 NEGATIVE REGULATION OF CELL GROWTH 4 170 0.0001014 0.003773
126 CARDIOVASCULAR SYSTEM DEVELOPMENT 7 788 0.0001048 0.003839
127 CIRCULATORY SYSTEM DEVELOPMENT 7 788 0.0001048 0.003839
128 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 172 0.0001061 0.003855
129 MACROMOLECULAR COMPLEX ASSEMBLY 9 1398 0.000108 0.003886
130 NEGATIVE REGULATION OF MOLECULAR FUNCTION 8 1079 0.0001086 0.003886
131 REGULATION OF NEURON DIFFERENTIATION 6 554 0.0001213 0.004309
132 REGULATION OF NOTCH SIGNALING PATHWAY 3 67 0.0001234 0.004349
133 REGULATION OF CELL PROJECTION ORGANIZATION 6 558 0.0001262 0.004382
134 CELL DEVELOPMENT 9 1426 0.0001258 0.004382
135 RESPONSE TO WOUNDING 6 563 0.0001325 0.00451
136 POSITIVE REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 2 12 0.0001328 0.00451
137 RESPONSE TO KETONE 4 182 0.0001319 0.00451
138 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 10 1805 0.0001408 0.004747
139 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 7 829 0.0001437 0.004811
140 MYELOID CELL DIFFERENTIATION 4 189 0.0001525 0.005068
141 MITOTIC CELL CYCLE ARREST 2 13 0.0001568 0.005077
142 PEPTIDYL AMINO ACID MODIFICATION 7 841 0.0001571 0.005077
143 REGULATION OF RESPONSE TO STRESS 9 1468 0.000157 0.005077
144 RESPONSE TO ALCOHOL 5 362 0.0001569 0.005077
145 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 74 0.0001658 0.00532
146 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 3 75 0.0001725 0.005499
147 POSITIVE REGULATION OF CELL ADHESION 5 376 0.0001873 0.005927
148 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 7 867 0.0001897 0.005958
149 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 6 602 0.0001908 0.005958
150 POSITIVE REGULATION OF CELL DEATH 6 605 0.000196 0.006056
151 NEGATIVE REGULATION OF CELL DEATH 7 872 0.0001965 0.006056
152 REGULATION OF ORGANELLE ORGANIZATION 8 1178 0.0001995 0.006109
153 NEGATIVE REGULATION OF CELL DIFFERENTIATION 6 609 0.0002031 0.006177
154 SINGLE ORGANISM BEHAVIOR 5 384 0.0002065 0.006239
155 NEUROTRANSMITTER UPTAKE 2 15 0.0002107 0.00624
156 NEGATIVE REGULATION OF TELOMERASE ACTIVITY 2 15 0.0002107 0.00624
157 RESPONSE TO INSULIN 4 205 0.0002082 0.00624
158 PROTEIN COMPLEX SUBUNIT ORGANIZATION 9 1527 0.0002119 0.00624
159 POSITIVE REGULATION OF CELL COMMUNICATION 9 1532 0.0002172 0.006317
160 POSITIVE REGULATION OF MAP KINASE ACTIVITY 4 207 0.0002161 0.006317
161 RESPONSE TO MECHANICAL STIMULUS 4 210 0.0002283 0.006599
162 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 4 211 0.0002325 0.006678
163 CELL PROJECTION ORGANIZATION 7 902 0.0002419 0.006907
164 RESPONSE TO PEPTIDE 5 404 0.0002612 0.007366
165 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 5 404 0.0002612 0.007366
166 PHOSPHORYLATION 8 1228 0.0002653 0.007438
167 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 2 17 0.0002724 0.007526
168 REPRODUCTIVE SYSTEM DEVELOPMENT 5 408 0.0002734 0.007526
169 NEGATIVE REGULATION OF ANOIKIS 2 17 0.0002724 0.007526
170 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 926 0.0002841 0.007777
171 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 90 0.0002958 0.008003
172 REGULATION OF CELL MATRIX ADHESION 3 90 0.0002958 0.008003
173 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 10 1977 0.0002988 0.008037
174 REGULATION OF MITOCHONDRIAL DEPOLARIZATION 2 18 0.0003062 0.008187
175 REGULATION OF MAPK CASCADE 6 660 0.0003133 0.008331
176 REGULATION OF CELL CYCLE 7 949 0.00033 0.008724
177 POSITIVE REGULATION OF T CELL PROLIFERATION 3 95 0.0003469 0.009067
178 REGULATION OF LIPID TRANSPORT 3 95 0.0003469 0.009067
179 MYELOID LEUKOCYTE DIFFERENTIATION 3 96 0.0003577 0.009298
180 RESPONSE TO VITAMIN 3 98 0.00038 0.009824
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN TYROSINE KINASE ACTIVITY 6 176 1.712e-07 0.0001278
2 ENZYME BINDING 13 1737 2.752e-07 0.0001278
3 PROTEIN KINASE ACTIVITY 8 640 2.491e-06 0.0007713
4 MOLECULAR FUNCTION REGULATOR 10 1353 1.184e-05 0.00275
5 KINASE ACTIVITY 8 842 1.862e-05 0.00346
6 IDENTICAL PROTEIN BINDING 9 1209 3.478e-05 0.005385
7 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 8 992 6.014e-05 0.007981
8 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 3 64 0.0001076 0.008725
9 PHOSPHATASE BINDING 4 162 8.412e-05 0.008725
10 HORMONE BINDING 3 65 0.0001127 0.008725
11 KINASE ACTIVATOR ACTIVITY 3 62 9.787e-05 0.008725
12 MONOCARBOXYLIC ACID BINDING 3 65 0.0001127 0.008725
13 KINASE REGULATOR ACTIVITY 4 186 0.0001434 0.009516
14 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 70 0.0001406 0.009516
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 7 352 5.511e-07 2.866e-05
2 MAPK_signaling_pathway_hsa04010 6 295 3.494e-06 9.085e-05
3 ErbB_signaling_pathway_hsa04012 4 85 6.654e-06 0.0001153
4 VEGF_signaling_pathway_hsa04370 3 59 8.437e-05 0.001097
5 Adherens_junction_hsa04520 3 72 0.0001528 0.001589
6 Rap1_signaling_pathway_hsa04015 4 206 0.0002122 0.001839
7 AMPK_signaling_pathway_hsa04152 3 121 0.0007036 0.005227
8 FoxO_signaling_pathway_hsa04068 3 132 0.0009057 0.005887
9 Tight_junction_hsa04530 3 170 0.001874 0.01083
10 Focal_adhesion_hsa04510 3 199 0.00293 0.01524
11 Ras_signaling_pathway_hsa04014 3 232 0.004507 0.0213
12 HIF_1_signaling_pathway_hsa04066 2 100 0.009203 0.03988
13 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.01889 0.07473
14 mTOR_signaling_pathway_hsa04150 2 151 0.02012 0.07473
15 Calcium_signaling_pathway_hsa04020 2 182 0.02847 0.09868
16 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.03636 0.1182
17 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.06113 0.187

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-253E3.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-378c;hsa-miR-93-5p 11 CD274 Sponge network 0.503 0.11427 0.445 0.09392 0.491
2 VIM-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-450b-5p;hsa-miR-93-5p 11 CD274 Sponge network 0.787 0.04236 0.445 0.09392 0.468
3 AC002480.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-378a-3p;hsa-miR-378c;hsa-miR-664a-3p;hsa-miR-93-5p 14 CD274 Sponge network 1.395 0.02402 0.445 0.09392 0.462
4 RP11-284N8.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-93-5p 10 CD274 Sponge network 0.275 0.55164 0.445 0.09392 0.373
5 APCDD1L-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-378c;hsa-miR-664a-3p;hsa-miR-93-5p 13 CD274 Sponge network 0.754 0.26534 0.445 0.09392 0.312
6 LINC00861 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-224-3p;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-450b-5p 10 CD274 Sponge network 0.483 0.39016 0.445 0.09392 0.303
7 RASSF8-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-378c;hsa-miR-429;hsa-miR-664a-3p;hsa-miR-93-5p 12 CD274 Sponge network 0.517 0.04957 0.445 0.09392 0.279
8 RP11-81H14.2 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-664a-3p 10 CD274 Sponge network 0.199 0.73841 0.445 0.09392 0.267
9 RP11-166D19.1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-378a-3p;hsa-miR-378c;hsa-miR-429;hsa-miR-450b-5p;hsa-miR-664a-3p 14 CD274 Sponge network 0.922 0.00515 0.445 0.09392 0.253

Quest ID: 7e97d287f5b2a3b4f8b36d18dc398213