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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-361-5p ABCA1 0.97 0 -0.71 0.00276 miRanda; mirMAP -0.32 0 NA
2 hsa-miR-361-5p ABCA8 0.97 0 -5.33 0 miRanda -0.7 0.00034 NA
3 hsa-miR-361-5p ABCD2 0.97 0 -3.08 0 miRanda -1.28 0 NA
4 hsa-miR-361-5p ABL1 0.97 0 -1.32 0 miRanda -0.32 0 NA
5 hsa-miR-361-5p ABL2 0.97 0 -0.32 0.04554 mirMAP -0.15 0.00146 NA
6 hsa-miR-361-5p ACACB 0.97 0 -2.93 0 miRanda -0.48 0 NA
7 hsa-miR-361-5p ACTC1 0.97 0 -7.19 0 miRanda; miRNATAP -3.21 0 NA
8 hsa-miR-361-5p ACTN4 0.97 0 -0.06 0.65476 miRanda -0.18 1.0E-5 NA
9 hsa-miR-361-5p ADAM12 0.97 0 0.88 0.05623 miRanda -0.82 0 NA
10 hsa-miR-361-5p ADAM19 0.97 0 -1.06 0.01895 miRanda -1.17 0 NA
11 hsa-miR-361-5p ADAM28 0.97 0 -0.73 0.15943 mirMAP -0.49 0.00113 NA
12 hsa-miR-361-5p ADAMTS5 0.97 0 -2.16 0 PITA; miRanda -0.64 0 NA
13 hsa-miR-361-5p ADCY2 0.97 0 -3.87 0 MirTarget; PITA; miRanda; miRNATAP -1.04 0 NA
14 hsa-miR-361-5p ADCY9 0.97 0 -1.5 0 miRanda -0.65 0 NA
15 hsa-miR-361-5p ADCYAP1 0.97 0 -3.51 0 miRanda -0.98 0 NA
16 hsa-miR-361-5p ADORA1 0.97 0 0.39 0.31104 miRanda -0.57 0 NA
17 hsa-miR-361-5p ADRA2A 0.97 0 -2.58 0 miRanda -0.88 0 NA
18 hsa-miR-361-5p AFF4 0.97 0 -0.82 0 miRanda -0.1 0.02408 NA
19 hsa-miR-361-5p AGPS 0.97 0 -0.1 0.48101 miRanda; miRNATAP -0.13 0.00105 NA
20 hsa-miR-361-5p AHNAK 0.97 0 -1.66 0 miRanda -0.55 0 NA
21 hsa-miR-361-5p AIDA 0.97 0 -0.31 0.01307 miRanda -0.22 0 NA
22 hsa-miR-361-5p AJAP1 0.97 0 -1.65 0.0004 miRanda -0.38 0.0057 NA
23 hsa-miR-361-5p AKAP11 0.97 0 -0.8 0 mirMAP -0.16 0.00083 NA
24 hsa-miR-361-5p AKAP12 0.97 0 -2.95 0 miRanda -0.63 0 NA
25 hsa-miR-361-5p AKAP5 0.97 0 0.05 0.84509 miRanda -0.19 0.02017 NA
26 hsa-miR-361-5p AKAP6 0.97 0 -3.34 0 miRanda -1.09 0 NA
27 hsa-miR-361-5p AKR1B10 0.97 0 -3.05 0.00095 miRanda -0.69 0.01017 NA
28 hsa-miR-361-5p ALDH1L2 0.97 0 -1.12 0.02448 miRanda; mirMAP; miRNATAP -1.11 0 NA
29 hsa-miR-361-5p ANGPT1 0.97 0 -2 1.0E-5 miRanda -0.48 0.00023 NA
30 hsa-miR-361-5p ANGPTL2 0.97 0 -1.73 0 miRanda -1.12 0 NA
31 hsa-miR-361-5p ANKRD44 0.97 0 -1.93 0 miRanda -0.64 0 NA
32 hsa-miR-361-5p ANO1 0.97 0 1.02 0.02235 miRanda; miRNATAP -0.27 0.0388 NA
33 hsa-miR-361-5p ANO6 0.97 0 -0.74 3.0E-5 MirTarget; miRanda -0.15 0.00429 NA
34 hsa-miR-361-5p AOC3 0.97 0 -3.69 0 MirTarget; miRanda -1.22 0 NA
35 hsa-miR-361-5p AP1S2 0.97 0 -1.31 0 miRanda -0.54 0 NA
36 hsa-miR-361-5p AP3S1 0.97 0 -0.06 0.68914 miRanda -0.15 0.0004 NA
37 hsa-miR-361-5p AP4S1 0.97 0 -0.6 0.00055 miRanda -0.21 3.0E-5 NA
38 hsa-miR-361-5p APBB2 0.97 0 -0.59 0.0014 miRanda -0.34 0 NA
39 hsa-miR-361-5p APOLD1 0.97 0 -2.62 0 miRanda -0.47 0 NA
40 hsa-miR-361-5p AQP9 0.97 0 0.86 0.13122 miRanda -1.04 0 NA
41 hsa-miR-361-5p ARF4 0.97 0 0.06 0.68077 miRNAWalker2 validate; miRanda -0.12 0.00153 NA
42 hsa-miR-361-5p ARFGAP3 0.97 0 -0.25 0.10361 miRanda -0.22 0 NA
43 hsa-miR-361-5p ARHGAP15 0.97 0 -1.33 0.00101 miRanda -0.79 0 NA
44 hsa-miR-361-5p ARHGAP20 0.97 0 -3.52 0 miRanda -1.28 0 NA
45 hsa-miR-361-5p ARHGAP21 0.97 0 -0.23 0.20424 miRanda -0.12 0.0273 NA
46 hsa-miR-361-5p ARHGAP31 0.97 0 -1.16 2.0E-5 mirMAP -0.6 0 NA
47 hsa-miR-361-5p ARHGAP6 0.97 0 -3.25 0 PITA; miRanda -0.36 0.0112 NA
48 hsa-miR-361-5p ARHGAP9 0.97 0 -0.84 0.05605 miRanda -0.92 0 NA
49 hsa-miR-361-5p ARHGEF37 0.97 0 -1.85 0 miRanda; miRNATAP -0.68 0 NA
50 hsa-miR-361-5p ARHGEF6 0.97 0 -1.32 0 miRanda -0.26 0.0017 NA
51 hsa-miR-361-5p ARL10 0.97 0 -1.12 0.00198 mirMAP -0.31 0.00375 NA
52 hsa-miR-361-5p ARL4C 0.97 0 -0.28 0.33535 miRanda -0.52 0 NA
53 hsa-miR-361-5p ARMC4 0.97 0 -3.15 0 miRNATAP -0.92 0 NA
54 hsa-miR-361-5p ARNTL 0.97 0 -0.36 0.08956 miRanda -0.27 1.0E-5 NA
55 hsa-miR-361-5p ARRB1 0.97 0 -1.05 0.00043 MirTarget; miRanda -0.2 0.02241 NA
56 hsa-miR-361-5p ARRDC3 0.97 0 -0.71 0.00062 MirTarget; PITA; miRanda; miRNATAP -0.23 9.0E-5 NA
57 hsa-miR-361-5p ARSB 0.97 0 -0.58 0.00052 miRanda -0.37 0 NA
58 hsa-miR-361-5p ART3 0.97 0 -1.79 0.00034 miRanda -0.72 0 NA
59 hsa-miR-361-5p ASXL3 0.97 0 -3.34 0 mirMAP -0.51 0.00129 NA
60 hsa-miR-361-5p ATAD1 0.97 0 -0.13 0.38155 miRanda -0.12 0.00433 NA
61 hsa-miR-361-5p ATF3 0.97 0 -3.23 0 miRanda -0.69 0 NA
62 hsa-miR-361-5p ATF7 0.97 0 -0.44 0.0002 mirMAP -0.13 0.00017 NA
63 hsa-miR-361-5p ATL3 0.97 0 -0.19 0.4343 mirMAP -0.25 0.0003 NA
64 hsa-miR-361-5p ATP8B4 0.97 0 -1.9 0 miRanda -0.93 0 NA
65 hsa-miR-361-5p AXL 0.97 0 -1.77 0 miRanda -1.02 0 NA
66 hsa-miR-361-5p B2M 0.97 0 -0 0.98848 miRanda -0.42 0 NA
67 hsa-miR-361-5p BACH1 0.97 0 -0.27 0.16316 miRanda; mirMAP -0.2 0.00029 NA
68 hsa-miR-361-5p BASP1 0.97 0 -0.12 0.79725 miRanda -0.26 0.04722 NA
69 hsa-miR-361-5p BBX 0.97 0 -0.51 0.00131 PITA; miRanda; mirMAP -0.12 0.00704 NA
70 hsa-miR-361-5p BCO2 0.97 0 -2.28 0 miRanda -0.31 0.00644 NA
71 hsa-miR-361-5p BDNF 0.97 0 -2.91 0 PITA; miRanda; miRNATAP -0.55 2.0E-5 NA
72 hsa-miR-361-5p BEND4 0.97 0 -1.97 7.0E-5 mirMAP -0.37 0.01166 NA
73 hsa-miR-361-5p BEND6 0.97 0 -0.8 0.03128 miRanda -0.46 2.0E-5 NA
74 hsa-miR-361-5p BIRC7 0.97 0 0.81 0.12357 miRanda -0.76 0 NA
75 hsa-miR-361-5p BMP2K 0.97 0 -0.34 0.13703 miRanda -0.18 0.00655 NA
76 hsa-miR-361-5p BMPR2 0.97 0 -0.59 4.0E-5 MirTarget; miRanda; mirMAP; miRNATAP -0.24 0 NA
77 hsa-miR-361-5p BRMS1L 0.97 0 -0.51 0.00391 miRanda -0.14 0.00562 NA
78 hsa-miR-361-5p BTG1 0.97 0 -0.8 2.0E-5 miRanda -0.23 2.0E-5 NA
79 hsa-miR-361-5p BTLA 0.97 0 -1.31 0.00559 miRanda -0.91 0 NA
80 hsa-miR-361-5p C1orf21 0.97 0 -1.51 0 mirMAP -0.16 0.02113 NA
81 hsa-miR-361-5p C2CD4A 0.97 0 0.55 0.29831 miRanda -0.37 0.01668 NA
82 hsa-miR-361-5p C4BPB 0.97 0 -0.9 0.15563 miRanda -0.38 0.03846 NA
83 hsa-miR-361-5p CACNB2 0.97 0 -2.97 0 miRanda -0.74 0 NA
84 hsa-miR-361-5p CACNB4 0.97 0 -2.87 0 miRanda; mirMAP -0.67 0 NA
85 hsa-miR-361-5p CALCOCO1 0.97 0 -1.07 0 miRanda -0.14 0.00122 NA
86 hsa-miR-361-5p CALCOCO2 0.97 0 -0.5 1.0E-5 miRNAWalker2 validate; miRanda -0.17 0 NA
87 hsa-miR-361-5p CALCRL 0.97 0 -0.67 0.01537 MirTarget; PITA; miRanda; miRNATAP -0.44 0 NA
88 hsa-miR-361-5p CALD1 0.97 0 -2.47 0 miRanda; miRNATAP -1.21 0 NA
89 hsa-miR-361-5p CALHM2 0.97 0 -0.53 0.01372 miRanda -0.24 0.0001 NA
90 hsa-miR-361-5p CAPN6 0.97 0 -3.48 0 PITA; miRanda; miRNATAP -0.55 0.00774 NA
91 hsa-miR-361-5p CASP1 0.97 0 -0.39 0.33513 miRanda -0.55 0 NA
92 hsa-miR-361-5p CASP4 0.97 0 0.1 0.69047 miRanda -0.25 0.00033 NA
93 hsa-miR-361-5p CAV1 0.97 0 -2.02 0 miRanda -1 0 NA
94 hsa-miR-361-5p CAV2 0.97 0 -0.86 0.01061 miRanda -0.63 0 NA
95 hsa-miR-361-5p CBLN1 0.97 0 -3.04 0 miRanda -0.69 2.0E-5 NA
96 hsa-miR-361-5p CBX6 0.97 0 -1.54 0 mirMAP -0.19 0.03211 NA
97 hsa-miR-361-5p CCDC152 0.97 0 -1.86 0 miRanda -0.44 0.00014 NA
98 hsa-miR-361-5p CCDC6 0.97 0 -0.27 0.05122 miRanda -0.24 0 NA
99 hsa-miR-361-5p CCDC88A 0.97 0 -0.76 0.01199 miRanda -0.35 6.0E-5 NA
100 hsa-miR-361-5p CCDC88B 0.97 0 0.26 0.37339 miRanda -0.19 0.0307 NA
101 hsa-miR-361-5p CCDC91 0.97 0 -0.41 0.01203 miRanda -0.16 0.00078 NA
102 hsa-miR-361-5p CCNYL1 0.97 0 -0.16 0.40711 MirTarget; miRanda; miRNATAP -0.16 0.00312 NA
103 hsa-miR-361-5p CCR6 0.97 0 -1.12 0.00057 miRanda -0.48 0 NA
104 hsa-miR-361-5p CD109 0.97 0 -0.51 0.31559 miRanda -0.95 0 NA
105 hsa-miR-361-5p CD177 0.97 0 -0.07 0.91649 miRanda; miRNATAP -0.73 6.0E-5 NA
106 hsa-miR-361-5p CD36 0.97 0 -1.94 0.00141 miRanda -0.56 0.00146 NA
107 hsa-miR-361-5p CD40 0.97 0 -0.38 0.28617 miRanda -0.33 0.00151 NA
108 hsa-miR-361-5p CD48 0.97 0 -1.58 0.00055 miRanda -0.98 0 NA
109 hsa-miR-361-5p CD84 0.97 0 -0.53 0.27947 mirMAP -1.08 0 NA
110 hsa-miR-361-5p CDADC1 0.97 0 -0.5 0.00184 miRanda -0.15 0.00124 NA
111 hsa-miR-361-5p CDC42BPA 0.97 0 -1.41 0 miRanda -0.36 0 NA
112 hsa-miR-361-5p CDH2 0.97 0 -0.37 0.51007 miRanda -0.9 0 NA
113 hsa-miR-361-5p CDK17 0.97 0 -0.52 0.00027 miRanda -0.15 0.00039 NA
114 hsa-miR-361-5p CEACAM21 0.97 0 -0.15 0.72613 miRanda -0.84 0 NA
115 hsa-miR-361-5p CELF2 0.97 0 -3.05 0 miRNATAP -1.27 0 NA
116 hsa-miR-361-5p CFL2 0.97 0 -2.62 0 miRanda -0.81 0 NA
117 hsa-miR-361-5p CGRRF1 0.97 0 -0.82 0 miRanda -0.1 0.005 NA
118 hsa-miR-361-5p CH25H 0.97 0 -3 0 miRanda -1.01 0 NA
119 hsa-miR-361-5p CHD9 0.97 0 -0.8 1.0E-5 PITA; miRanda -0.13 0.01508 NA
120 hsa-miR-361-5p CHST11 0.97 0 0.54 0.2311 miRanda -0.85 0 NA
121 hsa-miR-361-5p CISD1 0.97 0 -0.39 0.01804 miRNATAP -0.36 0 NA
122 hsa-miR-361-5p CISH 0.97 0 0.07 0.77166 miRanda -0.19 0.00414 NA
123 hsa-miR-361-5p CLDN11 0.97 0 -2.16 0 miRanda -0.33 0.01695 NA
124 hsa-miR-361-5p CLEC1A 0.97 0 -1.37 0 miRanda -0.53 0 NA
125 hsa-miR-361-5p CLEC3A 0.97 0 -5.97 0 miRanda -1.71 0 NA
126 hsa-miR-361-5p CLEC4E 0.97 0 -1.11 0.05437 miRanda -1.33 0 NA
127 hsa-miR-361-5p CLEC4GP1 0.97 0 -1.23 0.02196 miRanda -0.64 4.0E-5 NA
128 hsa-miR-361-5p CLEC7A 0.97 0 0.76 0.08786 miRanda -0.62 0 NA
129 hsa-miR-361-5p CLIC2 0.97 0 -1.44 0 PITA; miRanda; miRNATAP -0.53 0 NA
130 hsa-miR-361-5p CLIC4 0.97 0 -1.72 0 miRanda -0.82 0 NA
131 hsa-miR-361-5p CLIP4 0.97 0 -1.61 0 miRanda -0.63 0 NA
132 hsa-miR-361-5p CLN5 0.97 0 -0.32 0.02528 miRanda -0.15 0.00042 NA
133 hsa-miR-361-5p CLU 0.97 0 -2.85 0 miRanda -0.95 0 NA
134 hsa-miR-361-5p CMPK2 0.97 0 1.23 0.00022 miRanda -0.19 0.04534 NA
135 hsa-miR-361-5p CNRIP1 0.97 0 -2.41 0 miRanda -0.83 0 NA
136 hsa-miR-361-5p CNTLN 0.97 0 -1.17 0.00322 miRanda -0.42 0.00031 NA
137 hsa-miR-361-5p COBL 0.97 0 -2.83 2.0E-5 miRanda -0.44 0.02337 NA
138 hsa-miR-361-5p COL11A1 0.97 0 4.69 0 miRanda; miRNATAP -0.97 7.0E-5 NA
139 hsa-miR-361-5p COL14A1 0.97 0 -3.66 0 miRanda -1.07 0 NA
140 hsa-miR-361-5p COL15A1 0.97 0 -0.94 0.00988 miRanda -0.9 0 NA
141 hsa-miR-361-5p COL4A4 0.97 0 -2.67 0 MirTarget; miRanda -0.6 1.0E-5 NA
142 hsa-miR-361-5p CORIN 0.97 0 -0.97 0.01159 miRanda -0.41 0.00027 NA
143 hsa-miR-361-5p CORO1C 0.97 0 -1.12 0 miRanda -0.49 0 NA
144 hsa-miR-361-5p CPT1A 0.97 0 -0.83 0.00093 miRanda -0.25 0.00051 NA
145 hsa-miR-361-5p CR1 0.97 0 -1.99 0.00029 MirTarget; miRanda -1.22 0 NA
146 hsa-miR-361-5p CREB3L2 0.97 0 -0.29 0.1662 miRanda -0.16 0.01127 NA
147 hsa-miR-361-5p CREB5 0.97 0 -2.28 0 PITA; miRNATAP -0.75 0 NA
148 hsa-miR-361-5p CREG1 0.97 0 -0.22 0.23382 MirTarget; miRanda -0.15 0.00691 NA
149 hsa-miR-361-5p CSF2RA 0.97 0 -0.46 0.33646 miRanda -0.99 0 NA
150 hsa-miR-361-5p CSF3R 0.97 0 -0.24 0.56343 miRanda -0.59 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 154 1848 4.102e-21 1.909e-17
2 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 125 1395 1.333e-19 3.101e-16
3 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 137 1656 1.936e-18 2.777e-15
4 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 86 799 2.387e-18 2.777e-15
5 RESPONSE TO OXYGEN CONTAINING COMPOUND 121 1381 3.376e-18 3.141e-15
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 137 1672 4.416e-18 3.425e-15
7 REGULATION OF CELL DIFFERENTIATION 125 1492 3.052e-17 2.029e-14
8 POSITIVE REGULATION OF CELL COMMUNICATION 124 1532 5.983e-16 3.48e-13
9 RESPONSE TO ENDOGENOUS STIMULUS 119 1450 9.394e-16 4.857e-13
10 POSITIVE REGULATION OF RESPONSE TO STIMULUS 143 1929 3.689e-15 1.716e-12
11 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 92 1008 5.323e-15 2.251e-12
12 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 112 1360 6.003e-15 2.328e-12
13 REGULATION OF CELLULAR COMPONENT MOVEMENT 77 771 1.001e-14 3.581e-12
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 99 1142 1.177e-14 3.911e-12
15 NEUROGENESIS 112 1402 4.795e-14 1.488e-11
16 CELL MOTILITY 79 835 8.152e-14 2.231e-11
17 LOCALIZATION OF CELL 79 835 8.152e-14 2.231e-11
18 REGULATION OF CELL DEVELOPMENT 79 836 8.688e-14 2.246e-11
19 LOCOMOTION 95 1114 1.165e-13 2.853e-11
20 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 87 983 1.817e-13 4.228e-11
21 RESPONSE TO WOUNDING 61 563 2.068e-13 4.582e-11
22 BLOOD VESSEL MORPHOGENESIS 47 364 2.561e-13 5.416e-11
23 VASCULATURE DEVELOPMENT 54 469 4.702e-13 9.513e-11
24 INTRACELLULAR SIGNAL TRANSDUCTION 118 1572 6.669e-13 1.266e-10
25 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 68 689 7.074e-13 1.266e-10
26 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 102 1275 7.059e-13 1.266e-10
27 CARDIOVASCULAR SYSTEM DEVELOPMENT 74 788 7.703e-13 1.28e-10
28 CIRCULATORY SYSTEM DEVELOPMENT 74 788 7.703e-13 1.28e-10
29 POSITIVE REGULATION OF MOLECULAR FUNCTION 129 1791 8.984e-13 1.441e-10
30 REGULATION OF PHOSPHORUS METABOLIC PROCESS 120 1618 9.309e-13 1.444e-10
31 NEGATIVE REGULATION OF CELL COMMUNICATION 97 1192 1.031e-12 1.548e-10
32 REGULATION OF CELL PROLIFERATION 113 1496 1.498e-12 2.178e-10
33 WOUND HEALING 53 470 1.772e-12 2.498e-10
34 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 78 876 2.686e-12 3.675e-10
35 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 87 1036 3.265e-12 4.22e-10
36 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 87 1036 3.265e-12 4.22e-10
37 REGULATION OF MAPK CASCADE 64 660 7.564e-12 9.512e-10
38 REGULATION OF PROTEIN MODIFICATION PROCESS 122 1710 8.011e-12 9.81e-10
39 CELL DEVELOPMENT 107 1426 9.711e-12 1.159e-09
40 ANGIOGENESIS 39 293 1.117e-11 1.299e-09
41 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 41 321 1.253e-11 1.422e-09
42 RESPONSE TO LIPID 77 888 1.382e-11 1.531e-09
43 TISSUE DEVELOPMENT 111 1518 1.863e-11 2.016e-09
44 POSITIVE REGULATION OF MAPK CASCADE 51 470 1.982e-11 2.096e-09
45 CELLULAR RESPONSE TO LIPID 50 457 2.328e-11 2.407e-09
46 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 90 1135 3.025e-11 3.06e-09
47 RESPONSE TO NITROGEN COMPOUND 74 859 4.842e-11 4.793e-09
48 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 52 498 5.239e-11 5.079e-09
49 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 83 1021 5.617e-11 5.333e-09
50 POSITIVE REGULATION OF CELL DIFFERENTIATION 71 823 1.154e-10 1.074e-08
51 REGULATION OF TRANSPORT 123 1804 1.255e-10 1.145e-08
52 REGULATION OF ION TRANSPORT 57 592 1.47e-10 1.315e-08
53 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 69 801 2.29e-10 2.011e-08
54 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 66 750 2.376e-10 2.047e-08
55 REGULATION OF METAL ION TRANSPORT 39 325 2.619e-10 2.216e-08
56 CELLULAR RESPONSE TO NITROGEN COMPOUND 51 505 2.667e-10 2.216e-08
57 HOMEOSTATIC PROCESS 98 1337 2.957e-10 2.373e-08
58 RESPONSE TO GROWTH FACTOR 49 475 2.917e-10 2.373e-08
59 CELLULAR RESPONSE TO BIOTIC STIMULUS 26 163 6.252e-10 4.931e-08
60 CIRCULATORY SYSTEM PROCESS 41 366 7.483e-10 5.803e-08
61 REGULATION OF NEURON DIFFERENTIATION 53 554 8.367e-10 6.382e-08
62 REGULATION OF EPITHELIAL CELL PROLIFERATION 35 285 1.174e-09 8.813e-08
63 BIOLOGICAL ADHESION 80 1032 1.216e-09 8.981e-08
64 POSITIVE REGULATION OF CATALYTIC ACTIVITY 105 1518 1.642e-09 1.194e-07
65 REGULATION OF NEURON PROJECTION DEVELOPMENT 43 408 1.912e-09 1.369e-07
66 POSITIVE REGULATION OF TRANSPORT 74 936 2.297e-09 1.62e-07
67 REGULATION OF KINASE ACTIVITY 65 776 2.432e-09 1.689e-07
68 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 103 1492 2.671e-09 1.827e-07
69 POSITIVE REGULATION OF CELL PROLIFERATION 67 814 2.779e-09 1.874e-07
70 REGULATION OF CELL PROJECTION ORGANIZATION 52 558 3.013e-09 2.002e-07
71 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 85 1152 3.759e-09 2.433e-07
72 NEURON DIFFERENTIATION 70 874 3.765e-09 2.433e-07
73 POSITIVE REGULATION OF CELL DEVELOPMENT 46 472 6.315e-09 4.025e-07
74 PROTEIN PHOSPHORYLATION 73 944 7.584e-09 4.769e-07
75 NEGATIVE REGULATION OF CELL DIFFERENTIATION 54 609 8.476e-09 5.258e-07
76 CHEMICAL HOMEOSTASIS 69 874 8.79e-09 5.312e-07
77 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 37 337 8.759e-09 5.312e-07
78 REGULATION OF RESPONSE TO STRESS 100 1468 9.358e-09 5.582e-07
79 RESPONSE TO BACTERIUM 49 528 9.957e-09 5.864e-07
80 REGULATION OF CELL DEATH 100 1472 1.075e-08 6.253e-07
81 POSITIVE REGULATION OF KINASE ACTIVITY 46 482 1.21e-08 6.953e-07
82 POSITIVE REGULATION OF LOCOMOTION 42 420 1.387e-08 7.869e-07
83 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 43 437 1.499e-08 8.403e-07
84 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 124 1977 1.712e-08 9.486e-07
85 RESPONSE TO EXTERNAL STIMULUS 116 1821 2.33e-08 1.276e-06
86 REGULATION OF IMMUNE SYSTEM PROCESS 95 1403 3.083e-08 1.668e-06
87 IMMUNE SYSTEM PROCESS 123 1984 3.839e-08 2.053e-06
88 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 42 437 4.317e-08 2.283e-06
89 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 113 1784 4.951e-08 2.588e-06
90 REGULATION OF TRANSMEMBRANE TRANSPORT 41 426 6.023e-08 3.114e-06
91 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 71 957 6.48e-08 3.277e-06
92 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 21 138 6.426e-08 3.277e-06
93 REGULATION OF RESPONSE TO WOUNDING 40 413 7.372e-08 3.688e-06
94 POSITIVE REGULATION OF NEURON DIFFERENTIATION 33 306 8.567e-08 4.241e-06
95 CONNECTIVE TISSUE DEVELOPMENT 25 194 1.08e-07 5.291e-06
96 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 26 208 1.12e-07 5.431e-06
97 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 43 470 1.21e-07 5.807e-06
98 SKELETAL SYSTEM DEVELOPMENT 42 455 1.331e-07 6.319e-06
99 POSITIVE REGULATION OF HYDROLASE ACTIVITY 67 905 1.683e-07 7.908e-06
100 CYCLIC NUCLEOTIDE METABOLIC PROCESS 13 57 1.723e-07 8.019e-06
101 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 68 926 1.833e-07 8.442e-06
102 NEURON DEVELOPMENT 55 687 1.934e-07 8.693e-06
103 CARTILAGE DEVELOPMENT 21 147 1.943e-07 8.693e-06
104 REGULATION OF ORGAN MORPHOGENESIS 28 242 1.907e-07 8.693e-06
105 CELL PROLIFERATION 54 672 2.225e-07 9.861e-06
106 REGULATION OF MAP KINASE ACTIVITY 33 319 2.278e-07 9.998e-06
107 POSITIVE REGULATION OF GENE EXPRESSION 108 1733 2.322e-07 1.01e-05
108 TUBE DEVELOPMENT 47 552 2.657e-07 1.134e-05
109 REGULATION OF CELL MORPHOGENESIS 47 552 2.657e-07 1.134e-05
110 CELL CELL SIGNALING 59 767 2.682e-07 1.134e-05
111 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 27 232 2.795e-07 1.172e-05
112 RESPONSE TO CYTOKINE 56 714 2.92e-07 1.213e-05
113 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 17 102 3.019e-07 1.243e-05
114 RESPONSE TO PEPTIDE 38 404 3.294e-07 1.333e-05
115 CHONDROCYTE DIFFERENTIATION 13 60 3.272e-07 1.333e-05
116 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 36 372 3.38e-07 1.356e-05
117 ACTIVATION OF PROTEIN KINASE ACTIVITY 30 279 3.516e-07 1.398e-05
118 RESPONSE TO BIOTIC STIMULUS 65 886 3.588e-07 1.415e-05
119 REGULATION OF SYSTEM PROCESS 44 507 3.806e-07 1.488e-05
120 HEMOSTASIS 32 311 3.912e-07 1.517e-05
121 POSITIVE REGULATION OF ION TRANSPORT 27 236 3.946e-07 1.517e-05
122 NEGATIVE REGULATION OF CELL DEATH 64 872 4.368e-07 1.666e-05
123 REGULATION OF CYTOKINE PRODUCTION 47 563 4.694e-07 1.776e-05
124 RESPONSE TO ORGANIC CYCLIC COMPOUND 66 917 5.738e-07 2.153e-05
125 REGULATION OF TRANSPORTER ACTIVITY 24 198 6.06e-07 2.252e-05
126 DEVELOPMENTAL GROWTH 33 333 6.1e-07 2.252e-05
127 MUSCLE STRUCTURE DEVELOPMENT 39 432 6.573e-07 2.408e-05
128 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 31 303 6.712e-07 2.44e-05
129 REGULATION OF PHOSPHOLIPASE ACTIVITY 13 64 7.226e-07 2.583e-05
130 PEPTIDYL TYROSINE MODIFICATION 23 186 7.272e-07 2.583e-05
131 EXTRACELLULAR STRUCTURE ORGANIZATION 31 304 7.208e-07 2.583e-05
132 LEUKOCYTE MIGRATION 28 259 7.711e-07 2.698e-05
133 REGULATION OF SECRETION 54 699 7.656e-07 2.698e-05
134 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 9 29 8.318e-07 2.867e-05
135 REGULATION OF TRANSFERASE ACTIVITY 67 946 8.31e-07 2.867e-05
136 POSITIVE REGULATION OF CYTOKINE PRODUCTION 35 370 8.396e-07 2.873e-05
137 REGULATION OF BODY FLUID LEVELS 43 506 9.065e-07 3.028e-05
138 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 45 541 9.112e-07 3.028e-05
139 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 37 404 8.998e-07 3.028e-05
140 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 45 541 9.112e-07 3.028e-05
141 CENTRAL NERVOUS SYSTEM DEVELOPMENT 63 872 9.226e-07 3.044e-05
142 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 26 232 9.604e-07 3.147e-05
143 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 37 406 1.013e-06 3.282e-05
144 PHOSPHORYLATION 81 1228 1.016e-06 3.282e-05
145 REGULATION OF GROWTH 50 633 1.044e-06 3.349e-05
146 LIPID LOCALIZATION 28 264 1.133e-06 3.61e-05
147 GROWTH 37 410 1.282e-06 4.057e-05
148 POSITIVE REGULATION OF ENDOCYTOSIS 17 114 1.525e-06 4.762e-05
149 BEHAVIOR 43 516 1.518e-06 4.762e-05
150 REGULATION OF ERK1 AND ERK2 CASCADE 26 238 1.561e-06 4.841e-05
151 CELLULAR RESPONSE TO HORMONE STIMULUS 45 552 1.572e-06 4.844e-05
152 REGULATION OF HYDROLASE ACTIVITY 85 1327 1.769e-06 5.416e-05
153 POSITIVE REGULATION OF PROTEIN SECRETION 24 211 1.916e-06 5.827e-05
154 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 17 116 1.952e-06 5.899e-05
155 REGULATION OF CELL ADHESION 49 629 1.985e-06 5.958e-05
156 NEGATIVE REGULATION OF CELL DEVELOPMENT 30 303 2.004e-06 5.977e-05
157 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 20 156 2.163e-06 6.409e-05
158 POSITIVE REGULATION OF SECRETION 34 370 2.305e-06 6.787e-05
159 CELLULAR RESPONSE TO PEPTIDE 28 274 2.365e-06 6.92e-05
160 REGULATION OF LIPID STORAGE 10 41 2.386e-06 6.94e-05
161 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 48 616 2.509e-06 7.25e-05
162 REGULATION OF PROTEIN SECRETION 35 389 2.647e-06 7.602e-05
163 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 21 172 2.691e-06 7.682e-05
164 REGULATION OF CELLULAR COMPONENT BIOGENESIS 56 767 2.76e-06 7.83e-05
165 REGULATION OF ION HOMEOSTASIS 23 201 2.818e-06 7.945e-05
166 REGULATION OF LIPASE ACTIVITY 14 83 2.869e-06 8.042e-05
167 CELLULAR HOMEOSTASIS 51 676 3.09e-06 8.608e-05
168 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 42 513 3.147e-06 8.716e-05
169 SECOND MESSENGER MEDIATED SIGNALING 20 160 3.214e-06 8.85e-05
170 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 68 1004 3.26e-06 8.922e-05
171 REGULATION OF BLOOD CIRCULATION 29 295 3.409e-06 9.276e-05
172 POSITIVE REGULATION OF CYTOKINE SECRETION 15 96 3.446e-06 9.323e-05
173 TISSUE MORPHOGENESIS 43 533 3.504e-06 9.424e-05
174 NEGATIVE REGULATION OF IMMUNE RESPONSE 17 121 3.532e-06 9.445e-05
175 CAMP METABOLIC PROCESS 9 34 3.669e-06 9.756e-05
176 REGULATION OF HOMEOSTATIC PROCESS 38 447 3.867e-06 0.0001022
177 DEFENSE RESPONSE 79 1231 3.938e-06 0.0001035
178 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 39 465 3.992e-06 0.0001044
179 MUSCLE SYSTEM PROCESS 28 282 4.135e-06 0.0001075
180 REGULATION OF IMMUNE RESPONSE 60 858 4.744e-06 0.000122
181 SENSORY PERCEPTION OF PAIN 13 75 4.729e-06 0.000122
182 ION HOMEOSTASIS 45 576 4.837e-06 0.0001237
183 POSITIVE REGULATION OF GROWTH 25 238 4.996e-06 0.000127
184 POSITIVE REGULATION OF HEART GROWTH 8 27 5.087e-06 0.0001286
185 REGULATION OF CALCIUM ION TRANSPORT 23 209 5.463e-06 0.0001374
186 HEAD DEVELOPMENT 52 709 5.546e-06 0.0001387
187 NEURON PROJECTION DEVELOPMENT 43 545 6.144e-06 0.0001521
188 REGULATION OF SYNAPSE ORGANIZATION 16 113 6.139e-06 0.0001521
189 RESPONSE TO ABIOTIC STIMULUS 68 1024 6.328e-06 0.0001558
190 REGULATION OF CARDIAC MUSCLE CONTRACTION 12 66 6.546e-06 0.00016
191 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 15 101 6.567e-06 0.00016
192 REGULATION OF DEVELOPMENTAL GROWTH 28 289 6.608e-06 0.0001601
193 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 19 154 6.827e-06 0.0001638
194 NEGATIVE REGULATION OF TRANSPORT 38 458 6.805e-06 0.0001638
195 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 10 46 7.299e-06 0.0001742
196 POSITIVE REGULATION OF CELL DEATH 46 605 7.723e-06 0.0001833
197 REGULATION OF ENDOCYTOSIS 22 199 8.074e-06 0.0001907
198 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 105 1805 8.128e-06 0.000191
199 BONE DEVELOPMENT 19 156 8.25e-06 0.000191
200 RESPONSE TO HORMONE 61 893 8.195e-06 0.000191
201 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 19 156 8.25e-06 0.000191
202 REGULATION OF CELLULAR LOCALIZATION 80 1277 8.311e-06 0.0001914
203 SYSTEM PROCESS 104 1785 8.441e-06 0.0001935
204 REGULATION OF MEMBRANE POTENTIAL 31 343 8.935e-06 0.0002038
205 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 15 104 9.47e-06 0.0002139
206 REGULATION OF INTERLEUKIN 6 PRODUCTION 15 104 9.47e-06 0.0002139
207 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 14 92 9.95e-06 0.0002226
208 POSITIVE REGULATION OF ORGAN GROWTH 9 38 9.943e-06 0.0002226
209 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 24 233 1.072e-05 0.0002387
210 SYNAPSE ORGANIZATION 18 145 1.087e-05 0.0002401
211 REGULATION OF JNK CASCADE 19 159 1.089e-05 0.0002401
212 CELL DEATH 66 1001 1.095e-05 0.0002403
213 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 7 22 1.191e-05 0.0002603
214 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 12 70 1.23e-05 0.0002674
215 REGULATION OF PHOSPHOLIPASE C ACTIVITY 9 39 1.249e-05 0.0002691
216 MORPHOGENESIS OF AN EPITHELIUM 34 400 1.244e-05 0.0002691
217 REGULATION OF GTPASE ACTIVITY 49 673 1.257e-05 0.0002696
218 REGULATION OF CATABOLIC PROCESS 52 731 1.298e-05 0.0002757
219 MESENCHYME DEVELOPMENT 21 190 1.294e-05 0.0002757
220 SINGLE ORGANISM BEHAVIOR 33 384 1.329e-05 0.0002798
221 GLOMERULUS DEVELOPMENT 10 49 1.327e-05 0.0002798
222 REGULATION OF ANATOMICAL STRUCTURE SIZE 38 472 1.35e-05 0.000283
223 CELL CHEMOTAXIS 19 162 1.425e-05 0.0002961
224 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 162 1.425e-05 0.0002961
225 POSITIVE REGULATION OF MAP KINASE ACTIVITY 22 207 1.514e-05 0.0003131
226 VASCULAR PROCESS IN CIRCULATORY SYSTEM 19 163 1.557e-05 0.0003206
227 REGULATION OF OSSIFICATION 20 178 1.622e-05 0.0003324
228 MEMBRANE DEPOLARIZATION 11 61 1.718e-05 0.0003505
229 CELLULAR RESPONSE TO CYTOKINE STIMULUS 45 606 1.751e-05 0.0003554
230 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 6 16 1.757e-05 0.0003554
231 NEURON MIGRATION 15 110 1.888e-05 0.0003803
232 IMMUNE RESPONSE 70 1100 1.902e-05 0.0003815
233 REGULATION OF EPITHELIAL CELL MIGRATION 19 166 2.019e-05 0.0003998
234 FOREBRAIN CELL MIGRATION 11 62 2.017e-05 0.0003998
235 CELLULAR COMPONENT MORPHOGENESIS 60 900 2.013e-05 0.0003998
236 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 14 98 2.086e-05 0.0004112
237 PROTEIN LOCALIZATION 103 1805 2.234e-05 0.0004386
238 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 21 197 2.246e-05 0.0004391
239 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 22 213 2.368e-05 0.000461
240 AMEBOIDAL TYPE CELL MIGRATION 18 154 2.494e-05 0.0004835
241 REGULATION OF INFLAMMATORY RESPONSE 27 294 2.518e-05 0.0004862
242 CYCLIC NUCLEOTIDE CATABOLIC PROCESS 6 17 2.627e-05 0.000503
243 NEGATIVE REGULATION OF LIPID STORAGE 6 17 2.627e-05 0.000503
244 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 10 53 2.742e-05 0.000523
245 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 15 114 2.906e-05 0.0005496
246 CEREBRAL CORTEX CELL MIGRATION 9 43 2.899e-05 0.0005496
247 MEMBRANE ASSEMBLY 7 25 3.038e-05 0.00057
248 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 7 25 3.038e-05 0.00057
249 RHYTHMIC PROCESS 27 298 3.195e-05 0.000597
250 DEVELOPMENTAL CELL GROWTH 12 77 3.328e-05 0.0006194
251 COGNITION 24 251 3.669e-05 0.0006774
252 CELL ACTIVATION 42 568 3.666e-05 0.0006774
253 POSITIVE REGULATION OF LIPASE ACTIVITY 11 66 3.71e-05 0.0006823
254 NEGATIVE REGULATION OF PHOSPHORYLATION 34 422 3.744e-05 0.0006859
255 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 16 131 4.05e-05 0.000739
256 REGULATION OF HEART CONTRACTION 22 221 4.173e-05 0.0007579
257 STEM CELL DIFFERENTIATION 20 190 4.188e-05 0.0007579
258 MUSCLE CELL DIFFERENTIATION 23 237 4.202e-05 0.0007579
259 REGULATION OF STRIATED MUSCLE CONTRACTION 12 79 4.325e-05 0.000777
260 RESPONSE TO REACTIVE OXYGEN SPECIES 20 191 4.514e-05 0.0008079
261 REGULATION OF MUSCLE CONTRACTION 17 147 4.765e-05 0.0008494
262 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 57 867 4.787e-05 0.0008501
263 FOREBRAIN DEVELOPMENT 30 357 4.922e-05 0.0008677
264 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 18 162 4.923e-05 0.0008677
265 TUBE MORPHOGENESIS 28 323 5.057e-05 0.0008879
266 REGULATION OF PROTEIN LOCALIZATION 61 950 5.139e-05 0.000899
267 DEVELOPMENTAL MATURATION 20 193 5.234e-05 0.0009122
268 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 10 57 5.292e-05 0.0009188
269 MESENCHYMAL CELL DIFFERENTIATION 16 134 5.35e-05 0.0009254
270 GLOMERULAR EPITHELIUM DEVELOPMENT 6 19 5.394e-05 0.0009295
271 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 25 274 5.528e-05 0.0009492
272 REGULATION OF SEQUESTERING OF CALCIUM ION 14 107 5.665e-05 0.0009656
273 REGULATION OF CYTOKINE SECRETION 17 149 5.66e-05 0.0009656
274 CELL GROWTH 16 135 5.858e-05 0.0009949
275 ACTIN FILAMENT BASED PROCESS 35 450 5.938e-05 0.001005
276 REGULATION OF MUSCLE SYSTEM PROCESS 20 195 6.055e-05 0.001021
277 IMMUNE SYSTEM DEVELOPMENT 42 582 6.377e-05 0.001071
278 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 11 70 6.507e-05 0.001089
279 RESPONSE TO OXYGEN LEVELS 27 311 6.677e-05 0.001114
280 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 7 28 6.771e-05 0.001125
281 REGULATION OF DEFENSE RESPONSE 51 759 6.942e-05 0.00115
282 REGULATION OF ADAPTIVE IMMUNE RESPONSE 15 123 7.116e-05 0.001171
283 MULTI MULTICELLULAR ORGANISM PROCESS 21 213 7.119e-05 0.001171
284 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 24 262 7.269e-05 0.001189
285 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 17 152 7.282e-05 0.001189
286 RELAXATION OF MUSCLE 6 20 7.457e-05 0.001213
287 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 8 38 7.722e-05 0.001252
288 SECRETION 42 588 8.02e-05 0.001282
289 TISSUE MIGRATION 12 84 8.017e-05 0.001282
290 REGULATION OF AXONOGENESIS 18 168 7.938e-05 0.001282
291 POSITIVE REGULATION OF OSSIFICATION 12 84 8.017e-05 0.001282
292 POSITIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 13 97 8.05e-05 0.001283
293 AGING 24 264 8.19e-05 0.001301
294 REGULATION OF BLOOD PRESSURE 18 169 8.574e-05 0.001357
295 POSITIVE REGULATION OF CHEMOKINE PRODUCTION 9 49 8.605e-05 0.001357
296 UROGENITAL SYSTEM DEVELOPMENT 26 299 8.817e-05 0.001386
297 SYNAPTIC SIGNALING 33 424 9.45e-05 0.001476
298 REGULATION OF IMMUNE EFFECTOR PROCESS 33 424 9.45e-05 0.001476
299 REGULATION OF ORGAN GROWTH 11 73 9.645e-05 0.001501
300 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 12 86 0.0001012 0.00157
301 NEGATIVE REGULATION OF ION TRANSPORT 15 127 0.0001028 0.00159
302 REGULATION OF NEURON DEATH 23 252 0.0001078 0.00166
303 MEMBRANE BIOGENESIS 7 30 0.0001089 0.001673
304 RESPONSE TO PURINE CONTAINING COMPOUND 17 158 0.0001179 0.001805
305 HEART DEVELOPMENT 35 466 0.0001186 0.00181
306 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 5 14 0.0001205 0.001827
307 CAMP CATABOLIC PROCESS 5 14 0.0001205 0.001827
308 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 11 75 0.0001239 0.001872
309 REGULATION OF CELL KILLING 10 63 0.0001274 0.001919
310 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 25 289 0.0001299 0.00195
311 POSITIVE REGULATION OF CATABOLIC PROCESS 31 395 0.0001313 0.001965
312 NEGATIVE REGULATION OF MUSCLE CONTRACTION 6 22 0.0001345 0.001993
313 CELLULAR RESPONSE TO ACID CHEMICAL 18 175 0.0001342 0.001993
314 HOMEOSTASIS OF NUMBER OF CELLS 18 175 0.0001342 0.001993
315 RENAL SYSTEM PROCESS 13 102 0.0001356 0.002004
316 RESPONSE TO FIBROBLAST GROWTH FACTOR 14 116 0.0001375 0.002023
317 ORGAN MORPHOGENESIS 54 841 0.0001387 0.002023
318 POSITIVE REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 9 52 0.0001391 0.002023
319 CELL PROJECTION ORGANIZATION 57 902 0.0001382 0.002023
320 REGULATION OF LIPID CATABOLIC PROCESS 9 52 0.0001391 0.002023
321 DIVALENT INORGANIC CATION HOMEOSTASIS 28 343 0.0001423 0.002062
322 EPITHELIUM DEVELOPMENT 59 945 0.0001461 0.002106
323 LEARNING 15 131 0.0001462 0.002106
324 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 13 103 0.0001499 0.002153
325 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 117 0.0001508 0.002159
326 LEUKOCYTE DIFFERENTIATION 25 292 0.0001527 0.00218
327 ION TRANSPORT 74 1262 0.0001542 0.002194
328 REGULATION OF HEART GROWTH 8 42 0.0001629 0.00231
329 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 13 104 0.0001654 0.00234
330 REGULATION OF CHEMOKINE PRODUCTION 10 65 0.0001666 0.00235
331 SALIVARY GLAND DEVELOPMENT 7 32 0.0001685 0.002361
332 RESPONSE TO MECHANICAL STIMULUS 20 210 0.0001682 0.002361
333 POSITIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 5 15 0.0001751 0.00244
334 NEGATIVE REGULATION OF SMOOTH MUSCLE CONTRACTION 5 15 0.0001751 0.00244
335 CEREBRAL CORTEX DEVELOPMENT 13 105 0.0001823 0.002533
336 CELL SUBSTRATE ADHESION 17 164 0.0001859 0.002574
337 REGULATION OF CELLULAR RESPONSE TO STRESS 46 691 0.0001931 0.002667
338 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 21 229 0.0001981 0.002719
339 REGULATION OF DENDRITE DEVELOPMENT 14 120 0.0001976 0.002719
340 REGULATION OF SYNAPSE ASSEMBLY 11 79 0.0001991 0.002724
341 NEGATIVE REGULATION OF LOCOMOTION 23 263 0.0002031 0.002771
342 POSITIVE REGULATION OF RESPONSE TO CYTOKINE STIMULUS 7 33 0.0002069 0.002814
343 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 17 166 0.0002151 0.002918
344 REGULATION OF VESICLE MEDIATED TRANSPORT 34 462 0.0002166 0.002929
345 RESPONSE TO OXIDATIVE STRESS 28 352 0.000219 0.002954
346 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 6 24 0.0002272 0.003056
347 MORPHOGENESIS OF A BRANCHING STRUCTURE 17 167 0.0002312 0.0031
348 TAXIS 34 464 0.0002346 0.003137
349 POSITIVE REGULATION OF INTERLEUKIN 6 PRODUCTION 10 68 0.0002442 0.003256
350 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 20 216 0.0002452 0.003259
351 REGULATION OF FATTY ACID BETA OXIDATION 5 16 0.0002468 0.003271
352 CELLULAR RESPONSE TO OXIDATIVE STRESS 18 184 0.0002518 0.003329
353 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 16 153 0.0002573 0.003382
354 PALLIUM DEVELOPMENT 16 153 0.0002573 0.003382
355 REGULATION OF INTRACELLULAR TRANSPORT 42 621 0.0002609 0.00342
356 POSITIVE REGULATION OF AXONOGENESIS 10 69 0.000276 0.003607
357 INOSITOL LIPID MEDIATED SIGNALING 14 124 0.0002791 0.003637
358 NEGATIVE REGULATION OF CELL PROLIFERATION 43 643 0.0002814 0.003657
359 ENDOTHELIAL CELL MIGRATION 9 57 0.000287 0.00372
360 REGULATION OF VOLTAGE GATED CALCIUM CHANNEL ACTIVITY 6 25 0.0002894 0.00374
361 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 19 203 0.0003028 0.003892
362 NEGATIVE REGULATION OF CATABOLIC PROCESS 19 203 0.0003028 0.003892
363 CYTOKINE MEDIATED SIGNALING PATHWAY 33 452 0.0003078 0.003946
364 REGULATION OF POTASSIUM ION TRANSPORT 11 83 0.0003097 0.003959
365 NEURAL PRECURSOR CELL PROLIFERATION 10 70 0.0003111 0.003966
366 REGULATION OF IMMUNOGLOBULIN SECRETION 5 17 0.0003386 0.004282
367 REGULATION OF PROTEIN KINASE A SIGNALING 5 17 0.0003386 0.004282
368 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 0.0003386 0.004282
369 CELLULAR CHEMICAL HOMEOSTASIS 39 570 0.000341 0.0043
370 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 11 84 0.0003443 0.00433
371 RESPONSE TO ALCOHOL 28 362 0.0003456 0.004334
372 POSITIVE REGULATION OF BINDING 14 127 0.0003578 0.004475
373 NEGATIVE REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 8 47 0.0003667 0.00449
374 NEGATIVE REGULATION OF BLOOD CIRCULATION 7 36 0.0003659 0.00449
375 CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 7 36 0.0003659 0.00449
376 VASODILATION 6 26 0.0003641 0.00449
377 REGULATION OF SENSORY PERCEPTION 7 36 0.0003659 0.00449
378 NEGATIVE REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 7 36 0.0003659 0.00449
379 REGULATION OF AMINO ACID TRANSPORT 6 26 0.0003641 0.00449
380 REGULATION OF SENSORY PERCEPTION OF PAIN 7 36 0.0003659 0.00449
381 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 36 514 0.0003693 0.004511
382 NEGATIVE REGULATION OF CELL ADHESION 20 223 0.0003725 0.004537
383 VASCULOGENESIS 9 59 0.0003745 0.00455
384 REGULATION OF STEM CELL DIFFERENTIATION 13 113 0.0003793 0.004596
385 HEART PROCESS 11 85 0.0003821 0.004617
386 LIPID PHOSPHORYLATION 12 99 0.0003895 0.004695
387 NEURON PROJECTION MORPHOGENESIS 30 402 0.0003956 0.004756
388 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 18 191 0.0003976 0.004768
389 RESPONSE TO STEROID HORMONE 35 497 0.0004011 0.004798
390 SINGLE ORGANISM CELL ADHESION 33 459 0.0004046 0.004828
391 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 15 144 0.0004137 0.004897
392 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 15 144 0.0004137 0.004897
393 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 15 144 0.0004137 0.004897
394 REGULATION OF GLUCOSE IMPORT 9 60 0.0004259 0.005017
395 LEUKOCYTE HOMEOSTASIS 9 60 0.0004259 0.005017
396 MUSCLE ORGAN DEVELOPMENT 23 277 0.0004273 0.005021
397 NEGATIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 7 37 0.0004366 0.005104
398 CARDIAC MUSCLE CELL ACTION POTENTIAL 7 37 0.0004366 0.005104
399 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 23 278 0.0004495 0.005237
400 NEPHRON DEVELOPMENT 13 115 0.0004502 0.005237
401 REGULATION OF CYTOPLASMIC TRANSPORT 34 481 0.0004516 0.005241
402 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 5 18 0.0004542 0.005244
403 ORGAN MATURATION 5 18 0.0004542 0.005244
404 TISSUE REMODELING 11 87 0.0004681 0.005391
405 POSITIVE REGULATION OF SYNAPSE ASSEMBLY 9 61 0.000483 0.005549
406 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 8 49 0.0004917 0.005622
407 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 19 211 0.0004916 0.005622
408 COLLAGEN FIBRIL ORGANIZATION 7 38 0.0005177 0.00589
409 REGULATION OF CATION CHANNEL ACTIVITY 11 88 0.0005169 0.00589
410 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 17 179 0.0005218 0.005922
411 REGULATION OF RECEPTOR ACTIVITY 13 117 0.0005321 0.006009
412 LEUKOCYTE CHEMOTAXIS 13 117 0.0005321 0.006009
413 SECRETION BY CELL 34 486 0.0005428 0.006115
414 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 9 62 0.0005462 0.006138
415 RIBONUCLEOTIDE CATABOLIC PROCESS 6 28 0.0005583 0.00623
416 REGULATION OF CYTOKINE SECRETION INVOLVED IN IMMUNE RESPONSE 4 11 0.0005623 0.00623
417 REGULATION OF CHRONIC INFLAMMATORY RESPONSE 4 11 0.0005623 0.00623
418 MUSCLE HYPERTROPHY 6 28 0.0005583 0.00623
419 REGULATION OF FATTY ACID OXIDATION 6 28 0.0005583 0.00623
420 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 11 0.0005623 0.00623
421 REGULATION OF ORGANIC ACID TRANSPORT 8 50 0.0005661 0.006242
422 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 50 0.0005661 0.006242
423 ANION TRANSPORT 35 507 0.0005756 0.006332
424 RESPONSE TO MUSCLE STRETCH 5 19 0.0005972 0.006522
425 REGULATION OF CARDIAC MUSCLE CONTRACTION BY REGULATION OF THE RELEASE OF SEQUESTERED CALCIUM ION 5 19 0.0005972 0.006522
426 MUSCLE CELL CELLULAR HOMEOSTASIS 5 19 0.0005972 0.006522
427 POSITIVE REGULATION OF TRANSPORTER ACTIVITY 10 76 0.0006096 0.006636
428 LONG TERM SYNAPTIC POTENTIATION 7 39 0.0006104 0.006636
429 LEUKOCYTE ACTIVATION 30 414 0.0006416 0.006959
430 NEURAL CREST CELL MIGRATION 8 51 0.0006493 0.007026
431 SINGLE ORGANISM CELLULAR LOCALIZATION 54 898 0.0006775 0.007314
432 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I 11 91 0.0006893 0.00739
433 INFLAMMATORY RESPONSE 32 454 0.000689 0.00739
434 NEGATIVE REGULATION OF SECRETION 18 200 0.0006883 0.00739
435 LYMPHOCYTE ACTIVATION 26 342 0.0007165 0.007647
436 HINDBRAIN MORPHOGENESIS 7 40 0.0007158 0.007647
437 POSITIVE REGULATION OF CALCIUM ION TRANSPORT 12 106 0.0007277 0.00773
438 TRANSITION METAL ION HOMEOSTASIS 12 106 0.0007277 0.00773
439 SKELETAL MUSCLE ORGAN DEVELOPMENT 14 137 0.000771 0.008171
440 CELLULAR RESPONSE TO RETINOIC ACID 9 65 0.0007774 0.008203
441 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 9 65 0.0007774 0.008203
442 CELLULAR RESPONSE TO EPINEPHRINE STIMULUS 4 12 0.0008181 0.008612
443 DENDRITE DEVELOPMENT 10 79 0.0008305 0.008723
444 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 8 53 0.0008451 0.008823
445 RESPONSE TO INORGANIC SUBSTANCE 33 479 0.0008457 0.008823
446 REGULATION OF LEUKOCYTE MEDIATED CYTOTOXICITY 8 53 0.0008451 0.008823
447 RESPONSE TO ORGANOPHOSPHORUS 14 139 0.0008898 0.009262
448 ACTION POTENTIAL 11 94 0.000907 0.00942
449 RESPONSE TO INSULIN 18 205 0.0009176 0.009488
450 INSULIN RECEPTOR SIGNALING PATHWAY 10 80 0.0009173 0.009488
451 MUSCLE TISSUE DEVELOPMENT 22 275 0.0009254 0.009527
452 MONOCARBOXYLIC ACID TRANSPORT 13 124 0.0009245 0.009527
453 RESPONSE TO HYDROGEN PEROXIDE 12 109 0.000934 0.009594
454 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 8 54 0.0009595 0.009777
455 REGULATION OF ACTIN FILAMENT BASED PROCESS 24 312 0.0009602 0.009777
456 REGULATION OF SYNAPTIC PLASTICITY 14 140 0.0009547 0.009777
457 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 15 156 0.0009581 0.009777
458 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 9 67 0.0009718 0.009873
459 REGULATION OF RUFFLE ASSEMBLY 5 21 0.0009808 0.0099
460 CHONDROCYTE DEVELOPMENT 5 21 0.0009808 0.0099
461 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 5 21 0.0009808 0.0099
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 102 1476 3.057e-09 2.84e-06
2 PROTEIN DOMAIN SPECIFIC BINDING 54 624 1.946e-08 9.038e-06
3 KINASE BINDING 48 606 1.592e-06 0.0003697
4 LIPID BINDING 51 657 1.357e-06 0.0003697
5 GROWTH FACTOR RECEPTOR BINDING 18 129 2.032e-06 0.0003775
6 ACTIN BINDING 35 393 3.331e-06 0.0005157
7 ENZYME BINDING 103 1737 4.398e-06 0.0005837
8 CYTOSKELETAL PROTEIN BINDING 57 819 9.489e-06 0.001016
9 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 30 328 9.845e-06 0.001016
10 PROTEIN TYROSINE KINASE ACTIVITY 20 176 1.372e-05 0.001274
11 PROTEIN KINASE ACTIVITY 47 640 1.518e-05 0.001282
12 SIGNAL TRANSDUCER ACTIVITY 100 1731 1.822e-05 0.00141
13 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ACTIVITY 7 25 3.038e-05 0.001982
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 28 315 3.239e-05 0.001982
15 PHOSPHORIC DIESTER HYDROLASE ACTIVITY 13 90 3.627e-05 0.001982
16 PROTEIN COMPLEX BINDING 61 935 3.247e-05 0.001982
17 BINDING BRIDGING 19 173 3.607e-05 0.001982
18 KINASE ACTIVITY 56 842 4.074e-05 0.002102
19 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 12 81 5.571e-05 0.002584
20 ACTIN FILAMENT BINDING 15 121 5.88e-05 0.002584
21 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 22 228 6.675e-05 0.002584
22 MOLECULAR FUNCTION REGULATOR 80 1353 6.26e-05 0.002584
23 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 226 5.85e-05 0.002584
24 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 11 70 6.507e-05 0.002584
25 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 44 629 8.821e-05 0.003195
26 RECEPTOR ACTIVITY 93 1649 8.942e-05 0.003195
27 MACROMOLECULAR COMPLEX BINDING 81 1399 0.0001131 0.00389
28 IDENTICAL PROTEIN BINDING 72 1209 0.0001191 0.003953
29 GATED CHANNEL ACTIVITY 27 325 0.0001395 0.004181
30 SH3 DOMAIN BINDING 14 116 0.0001375 0.004181
31 PHOSPHOLIPID BINDING 29 360 0.0001371 0.004181
32 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 10 64 0.0001459 0.004236
33 PROTEIN KINASE A BINDING 8 42 0.0001629 0.004585
34 X3 5 CYCLIC AMP PHOSPHODIESTERASE ACTIVITY 5 15 0.0001751 0.00461
35 CALMODULIN BINDING 18 179 0.0001786 0.00461
36 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 5 15 0.0001751 0.00461
37 PROTEIN PHOSPHATASE BINDING 14 120 0.0001976 0.004754
38 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 43 0.0001935 0.004754
39 PHOSPHORIC ESTER HYDROLASE ACTIVITY 29 368 0.0001996 0.004754
40 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 34 464 0.0002346 0.00545
41 PROTEIN KINASE A REGULATORY SUBUNIT BINDING 5 16 0.0002468 0.005591
42 GROWTH FACTOR BINDING 14 123 0.0002564 0.005671
43 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 25 303 0.0002699 0.005832
44 HEPARIN BINDING 16 157 0.000345 0.007284
45 CYCLIC NUCLEOTIDE BINDING 7 36 0.0003659 0.007554
46 REGULATORY REGION NUCLEIC ACID BINDING 51 818 0.0004219 0.008521
47 PHOSPHATASE BINDING 16 162 0.00049 0.009685
48 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 59 992 0.0005087 0.009845
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 98 1151 4.992e-14 2.916e-11
2 INTRINSIC COMPONENT OF PLASMA MEMBRANE 123 1649 3.059e-13 8.933e-11
3 SYNAPSE 71 754 2.044e-12 3.361e-10
4 NEURON PROJECTION 82 942 2.302e-12 3.361e-10
5 NEURON PART 97 1265 3.128e-11 3.653e-09
6 POSTSYNAPSE 43 378 1.758e-10 1.711e-08
7 CELL SUBSTRATE JUNCTION 44 398 2.712e-10 2.262e-08
8 CELL SURFACE 66 757 3.506e-10 2.559e-08
9 MEMBRANE REGION 86 1134 8.036e-10 5.215e-08
10 SYNAPSE PART 56 610 1.265e-09 7.387e-08
11 MEMBRANE MICRODOMAIN 35 288 1.556e-09 8.261e-08
12 SOMATODENDRITIC COMPARTMENT 58 650 1.843e-09 8.967e-08
13 PLASMA MEMBRANE PROTEIN COMPLEX 49 510 3.211e-09 1.443e-07
14 CELL PROJECTION 117 1786 4.112e-09 1.715e-07
15 DENDRITE 43 451 3.75e-08 1.46e-06
16 ANCHORING JUNCTION 45 489 5.172e-08 1.888e-06
17 RECEPTOR COMPLEX 34 327 1.325e-07 4.55e-06
18 ACTIN CYTOSKELETON 41 444 1.86e-07 5.881e-06
19 SIDE OF MEMBRANE 40 428 1.913e-07 5.881e-06
20 CELL CORTEX 27 238 4.673e-07 1.365e-05
21 CYTOPLASMIC REGION 30 287 6.442e-07 1.739e-05
22 CELL LEADING EDGE 34 350 6.553e-07 1.739e-05
23 I BAND 18 121 7.831e-07 1.988e-05
24 PLASMA MEMBRANE RECEPTOR COMPLEX 22 175 9.516e-07 2.316e-05
25 PLASMA MEMBRANE REGION 65 929 1.846e-06 4.313e-05
26 PERINUCLEAR REGION OF CYTOPLASM 49 642 3.512e-06 7.64e-05
27 NEURON SPINE 17 121 3.532e-06 7.64e-05
28 POSTSYNAPTIC MEMBRANE 23 205 3.943e-06 8.223e-05
29 MEMBRANE PROTEIN COMPLEX 68 1020 5.555e-06 0.0001119
30 CONTRACTILE FIBER 23 211 6.408e-06 0.0001248
31 EXCITATORY SYNAPSE 22 197 6.859e-06 0.0001281
32 CELL BODY 40 494 7.02e-06 0.0001281
33 EXTRACELLULAR MATRIX 36 426 7.904e-06 0.0001399
34 SYNAPTIC MEMBRANE 26 261 8.532e-06 0.0001466
35 INTRACELLULAR VESICLE 79 1259 8.965e-06 0.0001496
36 GOLGI APPARATUS 87 1445 1.499e-05 0.0002432
37 SITE OF POLARIZED GROWTH 18 149 1.587e-05 0.0002504
38 EXTRACELLULAR SPACE 82 1376 3.847e-05 0.0005913
39 T TUBULE 9 45 4.255e-05 0.0006371
40 PROTEINACEOUS EXTRACELLULAR MATRIX 30 356 4.674e-05 0.0006824
41 FILOPODIUM 13 94 5.778e-05 0.0008231
42 ENDOPLASMIC RETICULUM 93 1631 5.997e-05 0.0008339
43 DENDRITIC SHAFT 8 37 6.306e-05 0.0008564
44 CYTOPLASMIC SIDE OF MEMBRANE 18 170 9.255e-05 0.001228
45 CELL PROJECTION PART 59 946 0.0001503 0.00195
46 AXON 32 418 0.0001624 0.002062
47 VACUOLE 70 1180 0.0001664 0.002068
48 CILIARY BASE 6 23 0.0001761 0.002142
49 TRANSPORTER COMPLEX 26 321 0.0002742 0.003269
50 EXTRACELLULAR MATRIX COMPONENT 14 125 0.0003035 0.003475
51 SARCOLEMMA 14 125 0.0003035 0.003475
52 LAMELLIPODIUM 17 172 0.0003281 0.003685
53 ENDOCYTIC VESICLE 22 256 0.000353 0.00389
54 PLASMA MEMBRANE RAFT 11 86 0.0004232 0.004577
55 PLATELET ALPHA GRANULE 10 75 0.0005478 0.005817
56 CYTOSKELETON 102 1967 0.0008519 0.008728
57 CELL CELL JUNCTION 28 383 0.0008375 0.008728

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04010_MAPK_signaling_pathway 32 268 1.204e-08 2.167e-06
2 hsa04014_Ras_signaling_pathway 29 236 3.072e-08 2.764e-06
3 hsa04151_PI3K_AKT_signaling_pathway 33 351 1.97e-06 0.0001182
4 hsa04270_Vascular_smooth_muscle_contraction 16 116 8.65e-06 0.0003893
5 hsa04730_Long.term_depression 12 70 1.23e-05 0.0004428
6 hsa04210_Apoptosis 13 89 3.213e-05 0.000964
7 hsa04020_Calcium_signaling_pathway 18 177 0.000155 0.003549
8 hsa04540_Gap_junction 12 90 0.0001577 0.003549
9 hsa04810_Regulation_of_actin_cytoskeleton 20 214 0.0002167 0.004333
10 hsa04380_Osteoclast_differentiation 14 128 0.0003879 0.006982
11 hsa04912_GnRH_signaling_pathway 12 101 0.0004686 0.007669
12 hsa04510_Focal_adhesion 18 200 0.0006883 0.01032
13 hsa04512_ECM.receptor_interaction 10 85 0.00147 0.01957
14 hsa04710_Circadian_rhythm_._mammal 5 23 0.001522 0.01957
15 hsa04520_Adherens_junction 9 73 0.001802 0.01983
16 hsa04640_Hematopoietic_cell_lineage 10 88 0.001915 0.01983
17 hsa04310_Wnt_signaling_pathway 14 151 0.001974 0.01983
18 hsa04971_Gastric_acid_secretion 9 74 0.001983 0.01983
19 hsa04062_Chemokine_signaling_pathway 16 189 0.002504 0.02372
20 hsa04145_Phagosome 14 156 0.002672 0.02404
21 hsa04722_Neurotrophin_signaling_pathway 12 127 0.003446 0.02954
22 hsa04972_Pancreatic_secretion 10 101 0.005244 0.0429
23 hsa04672_Intestinal_immune_network_for_IgA_production 6 49 0.01053 0.0824
24 hsa00565_Ether_lipid_metabolism 5 36 0.01134 0.08507
25 hsa04920_Adipocytokine_signaling_pathway 7 68 0.01487 0.0982
26 hsa04916_Melanogenesis 9 101 0.01517 0.0982
27 hsa04390_Hippo_signaling_pathway 12 154 0.01523 0.0982
28 hsa04650_Natural_killer_cell_mediated_cytotoxicity 11 136 0.01528 0.0982
29 hsa04630_Jak.STAT_signaling_pathway 12 155 0.01596 0.0984
30 hsa04720_Long.term_potentiation 7 70 0.01724 0.0984
31 hsa04142_Lysosome 10 121 0.01761 0.0984
32 hsa04012_ErbB_signaling_pathway 8 87 0.01804 0.0984
33 hsa04914_Progesterone.mediated_oocyte_maturation 8 87 0.01804 0.0984
34 hsa04970_Salivary_secretion 8 89 0.02042 0.1081
35 hsa00230_Purine_metabolism 12 162 0.0218 0.1121
36 hsa04614_Renin.angiotensin_system 3 17 0.02531 0.1246
37 hsa04370_VEGF_signaling_pathway 7 76 0.0259 0.1246
38 hsa00591_Linoleic_acid_metabolism 4 30 0.02631 0.1246
39 hsa04360_Axon_guidance 10 130 0.02745 0.1267
40 hsa04612_Antigen_processing_and_presentation 7 78 0.02935 0.1305
41 hsa04975_Fat_digestion_and_absorption 5 46 0.03025 0.1305
42 hsa04114_Oocyte_meiosis 9 114 0.03061 0.1305
43 hsa04664_Fc_epsilon_RI_signaling_pathway 7 79 0.03118 0.1305
44 hsa04514_Cell_adhesion_molecules_.CAMs. 10 136 0.03587 0.1467
45 hsa00592_alpha.Linolenic_acid_metabolism 3 20 0.039 0.1527
46 hsa04910_Insulin_signaling_pathway 10 138 0.03903 0.1527
47 hsa04620_Toll.like_receptor_signaling_pathway 8 102 0.04149 0.1589
48 hsa04130_SNARE_interactions_in_vesicular_transport 4 36 0.04733 0.1741
49 hsa04610_Complement_and_coagulation_cascades 6 69 0.04792 0.1741
50 hsa04144_Endocytosis 13 203 0.04835 0.1741
51 hsa04660_T_cell_receptor_signaling_pathway 8 108 0.05484 0.1935
52 hsa00590_Arachidonic_acid_metabolism 5 59 0.07429 0.2514
53 hsa04621_NOD.like_receptor_signaling_pathway 5 59 0.07429 0.2514
54 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 0.07542 0.2514
55 hsa00920_Sulfur_metabolism 2 13 0.08606 0.2725
56 hsa02010_ABC_transporters 4 44 0.08629 0.2725
57 hsa04962_Vasopressin.regulated_water_reabsorption 4 44 0.08629 0.2725
58 hsa04974_Protein_digestion_and_absorption 6 81 0.0893 0.2771
59 hsa04350_TGF.beta_signaling_pathway 6 85 0.1064 0.3245
60 hsa00120_Primary_bile_acid_biosynthesis 2 16 0.1229 0.3688
61 hsa03320_PPAR_signaling_pathway 5 70 0.1291 0.3808
62 hsa04976_Bile_secretion 5 71 0.1348 0.3858
63 hsa00450_Selenocompound_metabolism 2 17 0.136 0.3858
64 hsa04530_Tight_junction 8 133 0.1372 0.3858
65 hsa04670_Leukocyte_transendothelial_migration 7 117 0.1606 0.4374
66 hsa00531_Glycosaminoglycan_degradation 2 19 0.1628 0.4374
67 hsa04623_Cytosolic_DNA.sensing_pathway 4 56 0.1653 0.4376
68 hsa04260_Cardiac_muscle_contraction 5 77 0.1712 0.4466
69 hsa00620_Pyruvate_metabolism 3 40 0.1957 0.5032
70 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 2 22 0.2046 0.5186
71 hsa00760_Nicotinate_and_nicotinamide_metabolism 2 24 0.233 0.5745
72 hsa00510_N.Glycan_biosynthesis 3 49 0.2879 0.7003
73 hsa00512_Mucin_type_O.Glycan_biosynthesis 2 30 0.3188 0.7524
74 hsa04150_mTOR_signaling_pathway 3 52 0.3195 0.7524
75 hsa04662_B_cell_receptor_signaling_pathway 4 75 0.3219 0.7524
76 hsa04070_Phosphatidylinositol_signaling_system 4 78 0.3481 0.8032
77 hsa04340_Hedgehog_signaling_pathway 3 56 0.3617 0.8225
78 hsa00564_Glycerophospholipid_metabolism 4 80 0.3655 0.8225
79 hsa04140_Regulation_of_autophagy 2 34 0.3749 0.8331
80 hsa00600_Sphingolipid_metabolism 2 40 0.4551 0.9752
81 hsa04666_Fc_gamma_R.mediated_phagocytosis 4 95 0.4938 1
82 hsa04115_p53_signaling_pathway 3 69 0.4939 1
83 hsa00310_Lysine_degradation 2 44 0.5051 1
84 hsa04622_RIG.I.like_receptor_signaling_pathway 3 71 0.513 1
85 hsa00561_Glycerolipid_metabolism 2 50 0.5744 1
86 hsa04146_Peroxisome 3 79 0.5856 1
87 hsa00330_Arginine_and_proline_metabolism 2 54 0.6165 1
88 hsa03015_mRNA_surveillance_pathway 3 83 0.6192 1
89 hsa00140_Steroid_hormone_biosynthesis 2 57 0.6459 1
90 hsa04110_Cell_cycle 4 128 0.7254 1
91 hsa03018_RNA_degradation 2 71 0.7601 1
92 hsa04141_Protein_processing_in_endoplasmic_reticulum 5 168 0.7736 1
93 hsa04120_Ubiquitin_mediated_proteolysis 4 139 0.7823 1
94 hsa03013_RNA_transport 4 152 0.837 1
95 hsa00240_Pyrimidine_metabolism 2 99 0.8963 1
96 hsa04740_Olfactory_transduction 3 388 1 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-967K21.1 hsa-miR-140-5p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-29b-2-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-362-5p;hsa-miR-769-5p 10 EGFR Sponge network -1.206 0.01654 -0.229 0.5939 0.378
2 LINC00883 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-3913-5p 10 EGFR Sponge network -0.614 0.0511 -0.229 0.5939 0.376
3 AC002066.1 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-3913-5p;hsa-miR-7-1-3p 10 EGFR Sponge network -1.314 0.04594 -0.229 0.5939 0.355
4 AC005682.5 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-5p;hsa-miR-362-5p;hsa-miR-769-5p 12 EGFR Sponge network -0.787 0.08468 -0.229 0.5939 0.338
5 RP11-356J5.12 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-140-5p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-335-5p;hsa-miR-7-1-3p;hsa-miR-769-5p 15 EGFR Sponge network -2.015 0 -0.229 0.5939 0.286
6 RP11-411K7.1 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-140-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-195-3p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-374a-3p;hsa-miR-3913-5p;hsa-miR-7-1-3p 13 EGFR Sponge network -0.894 0.3797 -0.229 0.5939 0.283
7 RP3-439F8.1 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-374b-3p 11 EGFR Sponge network -0.149 0.78031 -0.229 0.5939 0.27
8 RP11-890B15.2 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-5p;hsa-miR-3913-5p;hsa-miR-769-5p 11 EGFR Sponge network 0.169 0.82185 -0.229 0.5939 0.26
9 RP11-221J22.2 hsa-miR-125a-5p;hsa-miR-128-3p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-29b-2-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-5p;hsa-miR-3913-5p;hsa-miR-769-5p 10 EGFR Sponge network 0.439 0.66705 -0.229 0.5939 0.258

Quest ID: 7eecef1efd270d970b227a77ff1295fe