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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200a-3p ABCA1 4.59 0 -0.71 0.00276 mirMAP -0.1 0 NA
2 hsa-miR-200b-3p ABCA1 3.78 0 -0.71 0.00276 TargetScan -0.12 0 NA
3 hsa-miR-200a-3p ABL1 4.59 0 -1.32 0 MirTarget -0.15 0 NA
4 hsa-miR-200a-3p ABL2 4.59 0 -0.32 0.04554 MirTarget; miRNATAP -0.14 0 NA
5 hsa-miR-200a-5p ABL2 3.86 0 -0.32 0.04554 mirMAP -0.15 0 NA
6 hsa-miR-200b-3p ABL2 3.78 0 -0.32 0.04554 MirTarget -0.15 0 NA
7 hsa-miR-200c-3p ABL2 3.5 0 -0.32 0.04554 MirTarget -0.15 0 NA
8 hsa-miR-200a-3p ACO1 4.59 0 -0.65 0.00055 MirTarget -0.12 0 NA
9 hsa-miR-200b-3p ACTC1 3.78 0 -7.19 0 MirTarget -1.07 0 NA
10 hsa-miR-200c-3p ACTC1 3.5 0 -7.19 0 MirTarget -1.34 0 NA
11 hsa-miR-200b-3p ADAMTS12 3.78 0 0.14 0.80728 mirMAP -0.47 0 NA
12 hsa-miR-200b-3p ADAMTS3 3.78 0 -1.18 0.00448 TargetScan -0.38 0 NA
13 hsa-miR-200c-3p ADAMTS3 3.5 0 -1.18 0.00448 miRNATAP -0.41 0 NA
14 hsa-miR-200b-3p ADAMTS5 3.78 0 -2.16 0 mirMAP -0.23 0 NA
15 hsa-miR-200a-3p ADARB1 4.59 0 -1.93 0 MirTarget -0.29 0 NA
16 hsa-miR-200b-3p ADCY2 3.78 0 -3.87 0 MirTarget; TargetScan -0.26 0 NA
17 hsa-miR-200c-3p ADCY2 3.5 0 -3.87 0 MirTarget; miRNATAP -0.44 0 NA
18 hsa-miR-200b-3p ADCY9 3.78 0 -1.5 0 TargetScan -0.26 0 NA
19 hsa-miR-200a-5p ADD2 3.86 0 -0.72 0.25015 mirMAP -0.3 0 NA
20 hsa-miR-200a-3p AFAP1 4.59 0 -0.98 0.00012 mirMAP -0.23 0 NA
21 hsa-miR-200c-5p AFF2 2.96 0 -1.73 0.00201 mirMAP -0.3 0 NA
22 hsa-miR-200a-5p AFF3 3.86 0 -5 0 MirTarget -0.49 0 NA
23 hsa-miR-200b-3p AFF3 3.78 0 -5 0 MirTarget; TargetScan -0.44 0 NA
24 hsa-miR-200c-3p AFF3 3.5 0 -5 0 MirTarget; miRNATAP -0.59 0 NA
25 hsa-miR-200b-3p AGFG1 3.78 0 -0.17 0.30925 MirTarget; TargetScan -0.11 0 NA
26 hsa-miR-200a-3p AGPAT4 4.59 0 -0.79 0.01174 mirMAP -0.2 0 NA
27 hsa-miR-200b-3p AHNAK 3.78 0 -1.66 0 TargetScan -0.2 0 NA
28 hsa-miR-200b-3p AKAP13 3.78 0 -1.15 0 mirMAP -0.12 0 NA
29 hsa-miR-200a-5p AKAP2 3.86 0 -2.51 8.0E-5 mirMAP -0.55 0 NA
30 hsa-miR-200b-3p AKAP2 3.78 0 -2.51 8.0E-5 TargetScan -0.54 0 NA
31 hsa-miR-200b-3p AMOTL2 3.78 0 -1.01 0.00015 MirTarget; TargetScan -0.23 0 NA
32 hsa-miR-200c-3p AMOTL2 3.5 0 -1.01 0.00015 MirTarget; miRNATAP -0.22 0 NA
33 hsa-miR-200a-3p AMZ1 4.59 0 0.48 0.33638 mirMAP -0.21 0 NA
34 hsa-miR-200a-3p ANGPTL1 4.59 0 -4.51 0 MirTarget -0.64 0 NA
35 hsa-miR-200a-3p ANK2 4.59 0 -4.32 0 miRNATAP -0.58 0 NA
36 hsa-miR-200b-3p ANKH 3.78 0 -0.38 0.21654 TargetScan -0.28 0 NA
37 hsa-miR-200c-3p ANKH 3.5 0 -0.38 0.21654 miRNATAP -0.29 0 NA
38 hsa-miR-200a-3p ANO5 4.59 0 -3.19 0 mirMAP -0.19 0.00012 NA
39 hsa-miR-200b-3p ANO5 3.78 0 -3.19 0 TargetScan -0.16 0.0024 NA
40 hsa-miR-200b-3p AP1S2 3.78 0 -1.31 0 MirTarget; TargetScan -0.32 0 NA
41 hsa-miR-200c-3p AP1S2 3.5 0 -1.31 0 MirTarget; miRNATAP -0.38 0 NA
42 hsa-miR-200a-3p APBB2 4.59 0 -0.59 0.0014 MirTarget; miRNATAP -0.16 0 NA
43 hsa-miR-200b-3p ARHGAP20 3.78 0 -3.52 0 MirTarget; TargetScan -0.42 0 NA
44 hsa-miR-200c-3p ARHGAP20 3.5 0 -3.52 0 MirTarget; miRNATAP -0.51 0 NA
45 hsa-miR-200a-3p ARHGAP24 4.59 0 -2.02 0 miRNATAP -0.34 0 NA
46 hsa-miR-200b-3p ARHGAP28 3.78 0 -1.54 0.00053 MirTarget -0.1 0.01457 NA
47 hsa-miR-200c-3p ARHGAP28 3.5 0 -1.54 0.00053 MirTarget -0.2 1.0E-5 NA
48 hsa-miR-200c-3p ARHGAP6 3.5 0 -3.25 0 MirTarget -0.12 0.0192 NA
49 hsa-miR-200b-3p ARHGEF17 3.78 0 -1.19 0 TargetScan -0.19 0 NA
50 hsa-miR-200c-3p ARHGEF17 3.5 0 -1.19 0 miRNATAP -0.24 0 NA
51 hsa-miR-200a-3p ARHGEF3 4.59 0 -0.76 0 mirMAP -0.1 0 NA
52 hsa-miR-200b-3p ARHGEF3 3.78 0 -0.76 0 MirTarget; TargetScan -0.1 0 NA
53 hsa-miR-200b-3p ARHGEF6 3.78 0 -1.32 0 mirMAP -0.13 0 NA
54 hsa-miR-200a-3p ARID5B 4.59 0 -1.57 0 miRNATAP -0.14 0 NA
55 hsa-miR-200b-3p ARID5B 3.78 0 -1.57 0 TargetScan -0.12 0 NA
56 hsa-miR-200a-3p ARL10 4.59 0 -1.12 0.00198 mirMAP -0.21 0 NA
57 hsa-miR-200b-3p ARL10 3.78 0 -1.12 0.00198 mirMAP -0.2 0 NA
58 hsa-miR-200c-3p ARL10 3.5 0 -1.12 0.00198 mirMAP -0.29 0 NA
59 hsa-miR-200a-3p ARNTL 4.59 0 -0.36 0.08956 MirTarget; miRNATAP -0.14 0 NA
60 hsa-miR-200a-5p ARNTL2 3.86 0 1.04 0.00449 MirTarget -0.16 1.0E-5 NA
61 hsa-miR-200b-3p ASAP1 3.78 0 0.06 0.77944 MirTarget; TargetScan -0.15 0 NA
62 hsa-miR-200c-3p ASAP1 3.5 0 0.06 0.77944 MirTarget; miRNATAP -0.16 0 NA
63 hsa-miR-200a-3p ASB1 4.59 0 -0.87 0 mirMAP -0.12 0 NA
64 hsa-miR-200b-3p ASXL3 3.78 0 -3.34 0 TargetScan -0.18 0.00036 NA
65 hsa-miR-200a-5p ATL3 3.86 0 -0.19 0.4343 MirTarget -0.16 0 NA
66 hsa-miR-200c-5p ATP1A2 2.96 0 -6.96 0 MirTarget -0.88 0 NA
67 hsa-miR-200a-3p ATP6V1B2 4.59 0 -0.17 0.24474 MirTarget; miRNATAP -0.11 0 NA
68 hsa-miR-200a-3p ATP8A1 4.59 0 -1.48 8.0E-5 MirTarget -0.12 0.00016 NA
69 hsa-miR-200a-5p ATP8B4 3.86 0 -1.9 0 MirTarget -0.39 0 NA
70 hsa-miR-200a-3p ATXN1 4.59 0 -1.51 0 MirTarget; miRNATAP -0.23 0 NA
71 hsa-miR-200b-3p ATXN1 3.78 0 -1.51 0 MirTarget; TargetScan -0.24 0 NA
72 hsa-miR-200c-3p ATXN1 3.5 0 -1.51 0 MirTarget; miRNATAP -0.24 0 NA
73 hsa-miR-200a-3p BACE1 4.59 0 -0.72 0.00096 mirMAP; miRNATAP -0.19 0 NA
74 hsa-miR-200a-3p BACH2 4.59 0 -1.52 0.00134 mirMAP -0.46 0 NA
75 hsa-miR-200b-3p BACH2 3.78 0 -1.52 0.00134 TargetScan; mirMAP -0.47 0 NA
76 hsa-miR-200c-3p BACH2 3.5 0 -1.52 0.00134 mirMAP -0.54 0 NA
77 hsa-miR-200b-3p BASP1 3.78 0 -0.12 0.79725 TargetScan -0.18 1.0E-5 NA
78 hsa-miR-200c-3p BASP1 3.5 0 -0.12 0.79725 miRNATAP -0.19 6.0E-5 NA
79 hsa-miR-200a-5p BCL2 3.86 0 -2.02 0 mirMAP -0.16 0 NA
80 hsa-miR-200b-3p BCL2 3.78 0 -2.02 0 miRNAWalker2 validate; miRTarBase; TargetScan; mirMAP -0.15 0 NA
81 hsa-miR-200c-3p BCL2 3.5 0 -2.02 0 miRNAWalker2 validate; miRTarBase; mirMAP -0.19 0 NA
82 hsa-miR-200a-3p BEND4 4.59 0 -1.97 7.0E-5 miRNATAP -0.25 0 NA
83 hsa-miR-200a-5p BEND4 3.86 0 -1.97 7.0E-5 mirMAP -0.25 0 NA
84 hsa-miR-200b-3p BEND4 3.78 0 -1.97 7.0E-5 mirMAP -0.25 0 NA
85 hsa-miR-200c-3p BEND4 3.5 0 -1.97 7.0E-5 mirMAP -0.32 0 NA
86 hsa-miR-200a-3p BHLHE40 4.59 0 -0.75 0.00869 miRNATAP -0.12 0 NA
87 hsa-miR-200b-3p BICC1 3.78 0 -1.47 0.01393 TargetScan -0.45 0 NA
88 hsa-miR-200b-3p BNC2 3.78 0 -2.95 0 MirTarget; TargetScan -0.58 0 NA
89 hsa-miR-200c-3p BNC2 3.5 0 -2.95 0 MirTarget -0.7 0 NA
90 hsa-miR-200a-3p BRMS1L 4.59 0 -0.51 0.00391 miRNATAP -0.11 0 NA
91 hsa-miR-200b-3p BRMS1L 3.78 0 -0.51 0.00391 TargetScan -0.11 0 NA
92 hsa-miR-200a-3p BVES 4.59 0 -2.76 0 mirMAP -0.42 0 NA
93 hsa-miR-200a-3p C11orf21 4.59 0 -1.31 0.00227 mirMAP -0.24 0 NA
94 hsa-miR-200b-3p C11orf87 3.78 0 -1.55 0.01186 TargetScan -0.26 1.0E-5 NA
95 hsa-miR-200c-3p C11orf87 3.5 0 -1.55 0.01186 miRNATAP -0.34 0 NA
96 hsa-miR-200b-3p C17orf51 3.78 0 -0.68 0.02254 mirMAP -0.22 0 NA
97 hsa-miR-200c-3p C17orf51 3.5 0 -0.68 0.02254 mirMAP -0.28 0 NA
98 hsa-miR-200b-3p CACHD1 3.78 0 -1.73 0 TargetScan -0.18 0 NA
99 hsa-miR-200b-3p CACNA1C 3.78 0 -2.53 0 MirTarget; TargetScan -0.3 0 NA
100 hsa-miR-200c-3p CACNA1C 3.5 0 -2.53 0 MirTarget -0.44 0 NA
101 hsa-miR-200b-3p CACNA2D1 3.78 0 -3.32 0 TargetScan -0.56 0 NA
102 hsa-miR-200c-5p CACNB2 2.96 0 -2.97 0 MirTarget; miRNATAP -0.35 0 NA
103 hsa-miR-200a-3p CADM2 4.59 0 -3.84 0 miRNATAP -0.2 9.0E-5 NA
104 hsa-miR-200b-3p CALU 3.78 0 -0.15 0.46318 MirTarget; TargetScan -0.21 0 NA
105 hsa-miR-200c-3p CALU 3.5 0 -0.15 0.46318 MirTarget -0.23 0 NA
106 hsa-miR-200a-3p CAMK4 4.59 0 -1.28 0.0022 mirMAP -0.29 0 NA
107 hsa-miR-200a-5p CAMK4 3.86 0 -1.28 0.0022 mirMAP -0.27 0 NA
108 hsa-miR-200c-5p CASQ2 2.96 0 -6.22 0 MirTarget -1.11 0 NA
109 hsa-miR-200c-3p CBL 3.5 0 -0.31 0.06484 MirTarget; mirMAP -0.11 0 NA
110 hsa-miR-200c-5p CCDC141 2.96 0 -2.94 0 MirTarget -0.44 0 NA
111 hsa-miR-200a-3p CCDC80 4.59 0 -3.33 0 MirTarget -0.63 0 NA
112 hsa-miR-200a-5p CCDC88A 3.86 0 -0.76 0.01199 miRNATAP -0.28 0 NA
113 hsa-miR-200a-3p CCND2 4.59 0 -2.43 0 MirTarget -0.32 0 NA
114 hsa-miR-200a-3p CCPG1 4.59 0 -1 0 MirTarget; miRNATAP -0.18 0 NA
115 hsa-miR-200a-3p CD274 4.59 0 0.06 0.90454 MirTarget -0.32 0 NA
116 hsa-miR-200a-3p CD47 4.59 0 -0.16 0.4808 miRNATAP -0.13 0 NA
117 hsa-miR-200a-3p CD59 4.59 0 -0.7 0.0013 mirMAP -0.14 0 NA
118 hsa-miR-200a-3p CDC42BPA 4.59 0 -1.41 0 mirMAP -0.13 0 NA
119 hsa-miR-200a-3p CDC42EP3 4.59 0 -1.35 0 MirTarget -0.21 0 NA
120 hsa-miR-200b-3p CDC42EP3 3.78 0 -1.35 0 TargetScan -0.23 0 NA
121 hsa-miR-200b-3p CDH11 3.78 0 -1.4 0.00163 TargetScan -0.33 0 NA
122 hsa-miR-200a-3p CDK6 4.59 0 -0.77 0.06479 miRNATAP -0.34 0 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6
123 hsa-miR-200b-3p CDK6 3.78 0 -0.77 0.06479 mirMAP -0.36 0 NA
124 hsa-miR-200c-3p CDK6 3.5 0 -0.77 0.06479 mirMAP -0.32 0 NA
125 hsa-miR-200a-3p CDON 4.59 0 -2.61 0 miRNATAP -0.34 0 NA
126 hsa-miR-200b-3p CDON 3.78 0 -2.61 0 mirMAP -0.34 0 NA
127 hsa-miR-200a-3p CDV3 4.59 0 -0.42 0.0021 miRNATAP -0.13 0 NA
128 hsa-miR-200b-3p CDYL2 3.78 0 -0.56 0.10685 TargetScan -0.13 5.0E-5 NA
129 hsa-miR-200a-3p CELF2 4.59 0 -3.05 0 mirMAP -0.42 0 NA
130 hsa-miR-200b-3p CELF2 3.78 0 -3.05 0 TargetScan; mirMAP -0.44 0 NA
131 hsa-miR-200c-3p CELF2 3.5 0 -3.05 0 mirMAP; miRNATAP -0.51 0 NA
132 hsa-miR-200c-5p CELF2 2.96 0 -3.05 0 miRNATAP -0.53 0 NA
133 hsa-miR-200b-3p CFL2 3.78 0 -2.62 0 MirTarget; TargetScan -0.42 0 NA
134 hsa-miR-200c-3p CFL2 3.5 0 -2.62 0 MirTarget; miRNATAP -0.48 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
135 hsa-miR-200a-5p CHL1 3.86 0 -2.42 0.00043 MirTarget; miRNATAP -0.2 0.00239 20957176 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis and highlight novel distinguishing characteristics of individual miR-200 family members
136 hsa-miR-200a-3p CHRDL1 4.59 0 -6.15 0 MirTarget -0.74 0 NA
137 hsa-miR-200b-3p CHRDL1 3.78 0 -6.15 0 MirTarget; TargetScan -0.75 0 NA
138 hsa-miR-200c-3p CHRDL1 3.5 0 -6.15 0 MirTarget -0.99 0 NA
139 hsa-miR-200b-3p CHST11 3.78 0 0.54 0.2311 mirMAP -0.42 0 NA
140 hsa-miR-200c-3p CHST11 3.5 0 0.54 0.2311 mirMAP -0.4 0 NA
141 hsa-miR-200b-3p CHSY1 3.78 0 -0.47 0.00149 TargetScan -0.11 0 NA
142 hsa-miR-200b-3p CHSY3 3.78 0 -0.52 0.14541 TargetScan -0.31 0 NA
143 hsa-miR-200b-3p CIITA 3.78 0 -0.02 0.95968 mirMAP -0.27 0 NA
144 hsa-miR-200c-3p CIITA 3.5 0 -0.02 0.95968 mirMAP -0.2 2.0E-5 NA
145 hsa-miR-200a-3p CLIC4 4.59 0 -1.72 0 MirTarget -0.38 0 NA
146 hsa-miR-200b-3p CLIC4 3.78 0 -1.72 0 MirTarget; TargetScan -0.4 0 NA
147 hsa-miR-200c-3p CLIC4 3.5 0 -1.72 0 MirTarget; miRNATAP -0.46 0 NA
148 hsa-miR-200b-3p CLIP2 3.78 0 -0.8 0.00158 MirTarget; TargetScan -0.1 1.0E-5 NA
149 hsa-miR-200c-3p CLIP2 3.5 0 -0.8 0.00158 MirTarget; miRNATAP -0.18 0 NA
150 hsa-miR-200b-3p CNKSR3 3.78 0 -1.81 0 TargetScan -0.1 0.00037 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 144 1426 2.122e-32 9.872e-29
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 149 1672 1.223e-27 2.845e-24
3 REGULATION OF CELL DIFFERENTIATION 137 1492 1.437e-26 2.229e-23
4 CARDIOVASCULAR SYSTEM DEVELOPMENT 94 788 3.293e-26 3.065e-23
5 CIRCULATORY SYSTEM DEVELOPMENT 94 788 3.293e-26 3.065e-23
6 NEUROGENESIS 131 1402 4.51e-26 3.498e-23
7 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 72 513 2.304e-24 1.532e-21
8 CELLULAR COMPONENT MORPHOGENESIS 96 900 4.074e-23 2.37e-20
9 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 103 1021 6.423e-23 3.321e-20
10 TISSUE DEVELOPMENT 131 1518 7.138e-23 3.321e-20
11 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 117 1275 1.478e-22 6.252e-20
12 REGULATION OF CELLULAR COMPONENT MOVEMENT 86 771 5.064e-22 1.963e-19
13 LOCOMOTION 105 1114 4.242e-21 1.518e-18
14 REGULATION OF CELL DEVELOPMENT 88 836 7.892e-21 2.623e-18
15 REGULATION OF NEURON DIFFERENTIATION 69 554 2.071e-20 6.424e-18
16 VASCULATURE DEVELOPMENT 62 469 9.695e-20 2.819e-17
17 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 103 1142 2.657e-19 7.271e-17
18 POSITIVE REGULATION OF CELL DIFFERENTIATION 84 823 4.621e-19 1.195e-16
19 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 78 750 3.223e-18 7.893e-16
20 HEART DEVELOPMENT 58 466 2.737e-17 6.368e-15
21 CENTRAL NERVOUS SYSTEM DEVELOPMENT 83 872 5.226e-17 1.158e-14
22 NEURON DIFFERENTIATION 83 874 5.986e-17 1.266e-14
23 ORGAN MORPHOGENESIS 81 841 6.524e-17 1.32e-14
24 MUSCLE STRUCTURE DEVELOPMENT 55 432 6.905e-17 1.339e-14
25 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 111 1395 1.01e-16 1.88e-14
26 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 50 368 1.291e-16 2.31e-14
27 SKELETAL SYSTEM DEVELOPMENT 56 455 1.647e-16 2.823e-14
28 NEURON PROJECTION DEVELOPMENT 62 545 1.699e-16 2.823e-14
29 NEURON PROJECTION MORPHOGENESIS 52 402 2.558e-16 4.105e-14
30 REGULATION OF CELL MORPHOGENESIS 62 552 3.134e-16 4.861e-14
31 REGULATION OF NEURON PROJECTION DEVELOPMENT 52 408 4.795e-16 7.197e-14
32 CELL MOTILITY 78 835 1.419e-15 2e-13
33 LOCALIZATION OF CELL 78 835 1.419e-15 2e-13
34 BLOOD VESSEL MORPHOGENESIS 48 364 1.76e-15 2.408e-13
35 REGULATION OF CELL PROJECTION ORGANIZATION 61 558 1.957e-15 2.601e-13
36 CELL PROJECTION ORGANIZATION 81 902 3.55e-15 4.588e-13
37 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 75 801 4.636e-15 5.83e-13
38 POSITIVE REGULATION OF NEURON DIFFERENTIATION 43 306 5.536e-15 6.779e-13
39 NEURON DEVELOPMENT 68 687 6.53e-15 7.791e-13
40 POSITIVE REGULATION OF CELL DEVELOPMENT 54 472 1.317e-14 1.525e-12
41 REGULATION OF CELL PROLIFERATION 111 1496 1.344e-14 1.525e-12
42 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 84 983 1.763e-14 1.953e-12
43 EXTRACELLULAR STRUCTURE ORGANIZATION 42 304 2.104e-14 2.276e-12
44 HEAD DEVELOPMENT 68 709 3.054e-14 3.23e-12
45 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 82 957 3.228e-14 3.337e-12
46 BIOLOGICAL ADHESION 86 1032 3.482e-14 3.522e-12
47 RESPONSE TO ENDOGENOUS STIMULUS 107 1450 6.283e-14 6.22e-12
48 RESPONSE TO WOUNDING 58 563 1.32e-13 1.24e-11
49 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 50 437 1.303e-13 1.24e-11
50 REGULATION OF CELL ADHESION 62 629 1.332e-13 1.24e-11
51 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 35 229 1.588e-13 1.449e-11
52 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 125 1848 1.934e-13 1.731e-11
53 REGULATION OF ACTIN FILAMENT BASED PROCESS 41 312 2.374e-13 2.084e-11
54 POSITIVE REGULATION OF GENE EXPRESSION 119 1733 2.999e-13 2.584e-11
55 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 82 1008 5.336e-13 4.514e-11
56 CELL PART MORPHOGENESIS 61 633 5.713e-13 4.747e-11
57 MESENCHYME DEVELOPMENT 31 190 6.655e-13 5.433e-11
58 NEGATIVE REGULATION OF CELL COMMUNICATION 91 1192 9.418e-13 7.555e-11
59 NEURON PROJECTION GUIDANCE 32 205 9.807e-13 7.734e-11
60 CONNECTIVE TISSUE DEVELOPMENT 31 194 1.178e-12 9.137e-11
61 FOREBRAIN DEVELOPMENT 43 357 1.253e-12 9.559e-11
62 REGULATION OF CHONDROCYTE DIFFERENTIATION 16 46 1.431e-12 1.074e-10
63 REGULATION OF CARTILAGE DEVELOPMENT 18 63 2.632e-12 1.944e-10
64 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 337 3.055e-12 2.221e-10
65 INTRACELLULAR SIGNAL TRANSDUCTION 108 1572 4.51e-12 3.229e-10
66 TAXIS 49 464 4.586e-12 3.233e-10
67 POSITIVE REGULATION OF CELL PROLIFERATION 69 814 6.862e-12 4.766e-10
68 TUBE DEVELOPMENT 54 552 7.323e-12 5.011e-10
69 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 111 1656 1.013e-11 6.815e-10
70 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 117 1784 1.025e-11 6.815e-10
71 STEM CELL DIFFERENTIATION 29 190 2.023e-11 1.326e-09
72 POSITIVE REGULATION OF LOCOMOTION 45 420 2.16e-11 1.396e-09
73 EMBRYONIC MORPHOGENESIS 52 539 3.056e-11 1.948e-09
74 REGULATION OF SYSTEM PROCESS 50 507 3.384e-11 2.128e-09
75 MUSCLE TISSUE DEVELOPMENT 35 275 3.438e-11 2.133e-09
76 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 95 1360 4.362e-11 2.67e-09
77 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 116 1805 4.616e-11 2.789e-09
78 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 60 689 6.028e-11 3.596e-09
79 REGULATION OF MEMBRANE POTENTIAL 39 343 8.267e-11 4.869e-09
80 TELENCEPHALON DEVELOPMENT 31 228 8.575e-11 4.988e-09
81 NEGATIVE REGULATION OF CELL DIFFERENTIATION 55 609 1.016e-10 5.834e-09
82 RESPONSE TO GROWTH FACTOR 47 475 1.2e-10 6.807e-09
83 EPITHELIUM DEVELOPMENT 73 945 1.241e-10 6.957e-09
84 POSITIVE REGULATION OF MOLECULAR FUNCTION 114 1791 1.263e-10 6.998e-09
85 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 36 303 1.297e-10 7.1e-09
86 REGULATION OF DEVELOPMENTAL GROWTH 35 289 1.385e-10 7.492e-09
87 CARDIAC CHAMBER DEVELOPMENT 24 144 1.712e-10 8.953e-09
88 EMBRYO DEVELOPMENT 70 894 1.71e-10 8.953e-09
89 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 29 207 1.689e-10 8.953e-09
90 MUSCLE ORGAN DEVELOPMENT 34 277 1.771e-10 9.158e-09
91 MUSCLE CELL DIFFERENTIATION 31 237 2.308e-10 1.18e-08
92 CARTILAGE DEVELOPMENT 24 147 2.661e-10 1.346e-08
93 NEGATIVE REGULATION OF CELL PROLIFERATION 56 643 2.704e-10 1.353e-08
94 MUSCLE SYSTEM PROCESS 34 282 2.872e-10 1.422e-08
95 REGULATION OF CELL DEATH 98 1472 2.934e-10 1.437e-08
96 UROGENITAL SYSTEM DEVELOPMENT 35 299 3.535e-10 1.714e-08
97 SENSORY ORGAN DEVELOPMENT 47 493 4.178e-10 2.004e-08
98 REGULATION OF PHOSPHORUS METABOLIC PROCESS 104 1618 5.564e-10 2.642e-08
99 CARDIAC SEPTUM DEVELOPMENT 18 85 5.997e-10 2.791e-08
100 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 30 232 5.972e-10 2.791e-08
101 NEGATIVE REGULATION OF LOCOMOTION 32 263 7.641e-10 3.486e-08
102 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 74 1004 7.61e-10 3.486e-08
103 ANGIOGENESIS 34 293 7.975e-10 3.603e-08
104 NEURON MIGRATION 20 110 1.175e-09 5.256e-08
105 MESENCHYMAL CELL DIFFERENTIATION 22 134 1.325e-09 5.873e-08
106 TISSUE MORPHOGENESIS 48 533 1.81e-09 7.943e-08
107 BEHAVIOR 47 516 1.862e-09 8.095e-08
108 ACTIN FILAMENT BASED PROCESS 43 450 2.203e-09 9.492e-08
109 TUBE MORPHOGENESIS 35 323 2.816e-09 1.202e-07
110 REGULATION OF OSSIFICATION 25 178 2.921e-09 1.236e-07
111 CARDIAC MUSCLE TISSUE DEVELOPMENT 22 140 3.102e-09 1.3e-07
112 REGULATION OF MUSCLE SYSTEM PROCESS 26 195 4.351e-09 1.808e-07
113 EPITHELIAL CELL DIFFERENTIATION 45 495 4.413e-09 1.817e-07
114 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 12 39 4.663e-09 1.903e-07
115 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 8 14 5.099e-09 2.063e-07
116 HEART MORPHOGENESIS 27 212 6.036e-09 2.421e-07
117 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 20 121 6.595e-09 2.623e-07
118 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 73 1036 6.869e-09 2.686e-07
119 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 73 1036 6.869e-09 2.686e-07
120 REGULATION OF CELL SUBSTRATE ADHESION 24 173 7.75e-09 3.005e-07
121 REGULATION OF GROWTH 52 633 8.899e-09 3.422e-07
122 PROTEIN PHOSPHORYLATION 68 944 9.872e-09 3.765e-07
123 POSITIVE REGULATION OF CELL COMMUNICATION 96 1532 1.028e-08 3.887e-07
124 GROWTH 39 410 1.413e-08 5.3e-07
125 REGULATION OF MUSCLE TISSUE DEVELOPMENT 18 103 1.521e-08 5.662e-07
126 COGNITION 29 251 1.555e-08 5.743e-07
127 MEMBRANE DEPOLARIZATION 14 61 1.631e-08 5.977e-07
128 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 57 740 1.68e-08 6.106e-07
129 POSITIVE REGULATION OF RESPONSE TO STIMULUS 113 1929 1.817e-08 6.555e-07
130 FOREBRAIN CELL MIGRATION 14 62 2.04e-08 7.303e-07
131 REGULATION OF EPITHELIAL CELL PROLIFERATION 31 285 2.082e-08 7.396e-07
132 WOUND HEALING 42 470 2.392e-08 8.398e-07
133 BONE DEVELOPMENT 22 156 2.4e-08 8.398e-07
134 CARDIAC MUSCLE CELL DIFFERENTIATION 15 74 3.042e-08 1.056e-06
135 CARDIOCYTE DIFFERENTIATION 17 96 3.109e-08 1.072e-06
136 HEART PROCESS 16 85 3.213e-08 1.099e-06
137 RESPONSE TO HORMONE 64 893 3.345e-08 1.136e-06
138 SKELETAL SYSTEM MORPHOGENESIS 25 201 3.548e-08 1.196e-06
139 RESPONSE TO ORGANIC CYCLIC COMPOUND 65 917 3.927e-08 1.315e-06
140 REGULATION OF PROTEIN MODIFICATION PROCESS 102 1710 4.166e-08 1.385e-06
141 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 59 799 4.203e-08 1.387e-06
142 CELLULAR RESPONSE TO HORMONE STIMULUS 46 552 4.296e-08 1.408e-06
143 RESPONSE TO OXYGEN CONTAINING COMPOUND 87 1381 4.361e-08 1.416e-06
144 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 43 498 4.382e-08 1.416e-06
145 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 55 724 4.829e-08 1.55e-06
146 REGULATION OF HEART CONTRACTION 26 221 5.96e-08 1.9e-06
147 DEVELOPMENTAL GROWTH 33 333 7.042e-08 2.229e-06
148 REGULATION OF EPITHELIAL CELL MIGRATION 22 166 7.496e-08 2.357e-06
149 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 62 876 8.7e-08 2.717e-06
150 REGULATION OF MAPK CASCADE 51 660 8.88e-08 2.736e-06
151 REGULATION OF TRANSPORT 105 1804 8.825e-08 2.736e-06
152 RESPIRATORY SYSTEM DEVELOPMENT 24 197 9.889e-08 3.027e-06
153 SINGLE ORGANISM CELL ADHESION 40 459 1.02e-07 3.101e-06
154 POSITIVE REGULATION OF CATALYTIC ACTIVITY 92 1518 1.033e-07 3.12e-06
155 CARDIAC CHAMBER MORPHOGENESIS 17 104 1.058e-07 3.175e-06
156 CELL JUNCTION ASSEMBLY 19 129 1.067e-07 3.182e-06
157 REGULATION OF TRANSMEMBRANE TRANSPORT 38 426 1.174e-07 3.48e-06
158 CELL JUNCTION ORGANIZATION 23 185 1.255e-07 3.697e-06
159 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 9 26 1.29e-07 3.774e-06
160 EYE DEVELOPMENT 32 326 1.384e-07 4.024e-06
161 REGULATION OF CYTOSKELETON ORGANIZATION 42 502 1.507e-07 4.355e-06
162 STRIATED MUSCLE CELL DIFFERENTIATION 22 173 1.574e-07 4.522e-06
163 REGULATION OF GTPASE ACTIVITY 51 673 1.631e-07 4.656e-06
164 SYSTEM PROCESS 103 1785 1.823e-07 5.172e-06
165 MORPHOGENESIS OF AN EPITHELIUM 36 400 2.035e-07 5.739e-06
166 OSSIFICATION 27 251 2.126e-07 5.959e-06
167 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 74 1152 2.328e-07 6.486e-06
168 RESPONSE TO EXTERNAL STIMULUS 104 1821 2.593e-07 7.183e-06
169 NEGATIVE REGULATION OF CELL DEVELOPMENT 30 303 2.822e-07 7.77e-06
170 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 7 15 2.996e-07 8.199e-06
171 CELL CELL SIGNALING 55 767 3.184e-07 8.592e-06
172 REGULATION OF CELLULAR COMPONENT BIOGENESIS 55 767 3.184e-07 8.592e-06
173 REGULATION OF OSTEOBLAST DIFFERENTIATION 17 112 3.194e-07 8.592e-06
174 NEGATIVE REGULATION OF GENE EXPRESSION 89 1493 3.533e-07 9.409e-06
175 REGULATION OF CELL SHAPE 19 139 3.539e-07 9.409e-06
176 PALLIUM DEVELOPMENT 20 153 3.658e-07 9.455e-06
177 CARDIAC MUSCLE CELL ACTION POTENTIAL 10 37 3.584e-07 9.455e-06
178 MORPHOGENESIS OF A BRANCHING STRUCTURE 21 167 3.633e-07 9.455e-06
179 REGULATION OF BMP SIGNALING PATHWAY 14 77 3.641e-07 9.455e-06
180 REGULATION OF STEM CELL DIFFERENTIATION 17 113 3.64e-07 9.455e-06
181 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 12 56 3.873e-07 9.956e-06
182 REGULATION OF EXTENT OF CELL GROWTH 16 101 3.895e-07 9.959e-06
183 POSITIVE REGULATION OF CELL ADHESION 34 376 3.976e-07 1.011e-05
184 APPENDAGE DEVELOPMENT 21 169 4.443e-07 1.117e-05
185 LIMB DEVELOPMENT 21 169 4.443e-07 1.117e-05
186 NEPHRON DEVELOPMENT 17 115 4.706e-07 1.177e-05
187 REGULATION OF MUSCLE ORGAN DEVELOPMENT 16 103 5.128e-07 1.276e-05
188 DIGESTIVE TRACT MORPHOGENESIS 11 48 5.766e-07 1.427e-05
189 SINGLE ORGANISM BEHAVIOR 34 384 6.467e-07 1.592e-05
190 CEREBRAL CORTEX DEVELOPMENT 16 105 6.703e-07 1.642e-05
191 SYNAPSE ORGANIZATION 19 145 6.875e-07 1.675e-05
192 ACTIN FILAMENT BASED MOVEMENT 15 93 7.066e-07 1.695e-05
193 CELL CELL ADHESION 46 608 6.997e-07 1.695e-05
194 VASCULOGENESIS 12 59 7.058e-07 1.695e-05
195 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 11 49 7.203e-07 1.71e-05
196 CARDIAC SEPTUM MORPHOGENESIS 11 49 7.203e-07 1.71e-05
197 NEGATIVE REGULATION OF PHOSPHORYLATION 36 422 7.415e-07 1.751e-05
198 CARDIAC VENTRICLE DEVELOPMENT 16 106 7.644e-07 1.796e-05
199 ACTION POTENTIAL 15 94 8.142e-07 1.896e-05
200 REGULATION OF ION TRANSPORT 45 592 8.149e-07 1.896e-05
201 REGULATION OF MUSCLE CONTRACTION 19 147 8.506e-07 1.969e-05
202 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 20 162 9.233e-07 2.127e-05
203 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 42 541 1.106e-06 2.511e-05
204 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 71 1135 1.105e-06 2.511e-05
205 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 42 541 1.106e-06 2.511e-05
206 CELL SUBSTRATE ADHESION 20 164 1.123e-06 2.537e-05
207 REGULATION OF ORGAN GROWTH 13 73 1.217e-06 2.736e-05
208 REGULATION OF CHEMOTAXIS 21 180 1.268e-06 2.837e-05
209 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 9 33 1.28e-06 2.849e-05
210 SKELETAL MUSCLE ORGAN DEVELOPMENT 18 137 1.293e-06 2.864e-05
211 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 88 1517 1.302e-06 2.871e-05
212 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 15 98 1.407e-06 3.089e-05
213 RESPONSE TO ALCOHOL 32 362 1.427e-06 3.117e-05
214 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 16 111 1.439e-06 3.129e-05
215 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 27 278 1.604e-06 3.472e-05
216 CEREBRAL CORTEX CELL MIGRATION 10 43 1.634e-06 3.503e-05
217 REGULATION OF BLOOD CIRCULATION 28 295 1.629e-06 3.503e-05
218 REGULATION OF AXONOGENESIS 20 168 1.646e-06 3.513e-05
219 ARTERY DEVELOPMENT 13 75 1.676e-06 3.56e-05
220 HEART VALVE DEVELOPMENT 9 34 1.687e-06 3.568e-05
221 NEGATIVE REGULATION OF CELL DEATH 58 872 1.73e-06 3.643e-05
222 REGULATION OF HYDROLASE ACTIVITY 79 1327 1.816e-06 3.807e-05
223 VENTRICULAR SEPTUM DEVELOPMENT 11 54 2.021e-06 4.216e-05
224 REGULATION OF ENDOTHELIAL CELL MIGRATION 16 114 2.066e-06 4.291e-05
225 POST EMBRYONIC DEVELOPMENT 14 89 2.252e-06 4.658e-05
226 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 102 2.363e-06 4.865e-05
227 REGULATION OF CARDIAC MUSCLE CONTRACTION 12 66 2.485e-06 5.093e-05
228 REGULATION OF CELLULAR COMPONENT SIZE 30 337 2.628e-06 5.364e-05
229 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 15 103 2.678e-06 5.442e-05
230 REGULATION OF CELL GROWTH 33 391 2.703e-06 5.467e-05
231 NEGATIVE REGULATION OF GROWTH 24 236 2.714e-06 5.467e-05
232 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 17 131 3.013e-06 6.043e-05
233 RESPONSE TO LIPID 58 888 3.047e-06 6.085e-05
234 NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 7 20 3.099e-06 6.163e-05
235 GLIOGENESIS 20 175 3.116e-06 6.169e-05
236 REGULATION OF CELL JUNCTION ASSEMBLY 12 68 3.449e-06 6.801e-05
237 POSITIVE REGULATION OF MAPK CASCADE 37 470 3.505e-06 6.882e-05
238 CORONARY VASCULATURE DEVELOPMENT 9 37 3.645e-06 7.126e-05
239 REGULATION OF ANATOMICAL STRUCTURE SIZE 37 472 3.866e-06 7.526e-05
240 DIGESTIVE SYSTEM DEVELOPMENT 18 148 3.98e-06 7.717e-05
241 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 85 1492 4.102e-06 7.92e-05
242 REGULATION OF ORGAN MORPHOGENESIS 24 242 4.206e-06 8.086e-05
243 AMINOGLYCAN BIOSYNTHETIC PROCESS 15 107 4.35e-06 8.33e-05
244 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 8 29 4.586e-06 8.711e-05
245 CARDIAC MUSCLE CELL CONTRACTION 8 29 4.586e-06 8.711e-05
246 CELL FATE COMMITMENT 23 227 4.64e-06 8.776e-05
247 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 12 70 4.73e-06 8.91e-05
248 PHOSPHORYLATION 73 1228 4.87e-06 9.136e-05
249 REGULATION OF KINASE ACTIVITY 52 776 4.898e-06 9.154e-05
250 CIRCULATORY SYSTEM PROCESS 31 366 5.026e-06 9.354e-05
251 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 262 5.309e-06 9.83e-05
252 ACTIVATION OF PROTEIN KINASE ACTIVITY 26 279 5.324e-06 9.83e-05
253 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 19 166 5.348e-06 9.835e-05
254 MULTICELLULAR ORGANISMAL SIGNALING 16 123 5.675e-06 0.000104
255 ION TRANSMEMBRANE TRANSPORT 54 822 5.716e-06 0.0001043
256 GLOMERULUS DEVELOPMENT 10 49 5.801e-06 0.0001054
257 REGULATION OF PHOSPHOLIPASE C ACTIVITY 9 39 5.834e-06 0.0001056
258 CHONDROCYTE DIFFERENTIATION 11 60 5.986e-06 0.000108
259 EMBRYONIC ORGAN DEVELOPMENT 33 406 6.037e-06 0.0001085
260 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 8 30 6.065e-06 0.0001085
261 POSITIVE REGULATION OF KINASE ACTIVITY 37 482 6.238e-06 0.00011
262 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 17 138 6.168e-06 0.00011
263 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 13 84 6.217e-06 0.00011
264 TISSUE MIGRATION 13 84 6.217e-06 0.00011
265 IMMUNE SYSTEM DEVELOPMENT 42 582 6.969e-06 0.000122
266 KIDNEY EPITHELIUM DEVELOPMENT 16 125 7.006e-06 0.000122
267 REGULATION OF ADHERENS JUNCTION ORGANIZATION 10 50 7.027e-06 0.000122
268 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 10 50 7.027e-06 0.000122
269 MUSCLE CONTRACTION 23 233 7.171e-06 0.0001236
270 MODULATION OF SYNAPTIC TRANSMISSION 27 301 7.172e-06 0.0001236
271 CARDIAC VENTRICLE MORPHOGENESIS 11 62 8.335e-06 0.0001426
272 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 62 8.335e-06 0.0001426
273 CELL SUBSTRATE JUNCTION ASSEMBLY 9 41 9.064e-06 0.0001545
274 MUSCLE CELL DEVELOPMENT 16 128 9.529e-06 0.0001618
275 REGULATION OF CELL CELL ADHESION 31 380 1.069e-05 0.0001809
276 POSITIVE REGULATION OF HYDROLASE ACTIVITY 57 905 1.096e-05 0.0001841
277 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 17 144 1.096e-05 0.0001841
278 REGULATION OF HEART GROWTH 9 42 1.118e-05 0.0001872
279 CELLULAR RESPONSE TO LIPID 35 457 1.164e-05 0.0001941
280 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 20 191 1.177e-05 0.0001955
281 SECOND MESSENGER MEDIATED SIGNALING 18 160 1.195e-05 0.0001979
282 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 7 24 1.225e-05 0.0002008
283 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 7 24 1.225e-05 0.0002008
284 NEGATIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 7 24 1.225e-05 0.0002008
285 LEARNING 16 131 1.283e-05 0.0002095
286 REGULATION OF CELL MATRIX ADHESION 13 90 1.349e-05 0.0002187
287 MESONEPHROS DEVELOPMENT 13 90 1.349e-05 0.0002187
288 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 15 118 1.467e-05 0.0002369
289 REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 6 17 1.536e-05 0.0002473
290 CELL MATRIX ADHESION 15 119 1.625e-05 0.0002607
291 DENDRITE DEVELOPMENT 12 79 1.712e-05 0.0002718
292 REGULATION OF STRIATED MUSCLE CONTRACTION 12 79 1.712e-05 0.0002718
293 BONE MORPHOGENESIS 12 79 1.712e-05 0.0002718
294 RHYTHMIC PROCESS 26 298 1.719e-05 0.000272
295 POSITIVE REGULATION OF CELL DEATH 42 605 1.77e-05 0.0002792
296 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 11 67 1.8e-05 0.0002805
297 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 103 1977 1.802e-05 0.0002805
298 POSITIVE REGULATION OF CHEMOTAXIS 15 120 1.799e-05 0.0002805
299 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 11 67 1.8e-05 0.0002805
300 LOCOMOTORY BEHAVIOR 19 181 1.867e-05 0.0002896
301 POSITIVE REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 5 11 1.939e-05 0.0002997
302 RESPONSE TO NITROGEN COMPOUND 54 859 1.979e-05 0.0003045
303 AMINOGLYCAN METABOLIC PROCESS 18 166 1.983e-05 0.0003045
304 SPROUTING ANGIOGENESIS 9 45 2.025e-05 0.0003099
305 GLIAL CELL DIFFERENTIATION 16 136 2.064e-05 0.0003148
306 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 11 68 2.081e-05 0.0003164
307 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 22 232 2.119e-05 0.0003211
308 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 15 122 2.196e-05 0.0003317
309 ION TRANSPORT 72 1262 2.268e-05 0.0003404
310 HINDBRAIN DEVELOPMENT 16 137 2.263e-05 0.0003404
311 DIVALENT INORGANIC CATION TRANSPORT 24 268 2.349e-05 0.0003515
312 ENDOTHELIAL CELL MIGRATION 10 57 2.373e-05 0.0003539
313 REGULATION OF ION HOMEOSTASIS 20 201 2.49e-05 0.0003702
314 CARDIAC CONDUCTION 12 82 2.518e-05 0.0003732
315 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 17 154 2.657e-05 0.0003912
316 AMEBOIDAL TYPE CELL MIGRATION 17 154 2.657e-05 0.0003912
317 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 33 437 2.733e-05 0.0004012
318 MUSCLE ORGAN MORPHOGENESIS 11 70 2.758e-05 0.0004036
319 PROTEOGLYCAN METABOLIC PROCESS 12 83 2.852e-05 0.000416
320 POSITIVE REGULATION OF HEART GROWTH 7 27 2.871e-05 0.0004162
321 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 7 27 2.871e-05 0.0004162
322 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 17 156 3.14e-05 0.0004537
323 ENDODERM DEVELOPMENT 11 71 3.163e-05 0.0004543
324 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 6 19 3.173e-05 0.0004543
325 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 6 19 3.173e-05 0.0004543
326 REGULATION OF CELL SIZE 18 172 3.205e-05 0.0004574
327 POSITIVE REGULATION OF OSSIFICATION 12 84 3.224e-05 0.0004587
328 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 9 48 3.492e-05 0.0004953
329 TRANSMEMBRANE TRANSPORT 64 1098 3.512e-05 0.0004967
330 NEGATIVE REGULATION OF CELL ADHESION 21 223 3.593e-05 0.0005066
331 OLIGODENDROCYTE DIFFERENTIATION 10 60 3.772e-05 0.0005302
332 STRIATED MUSCLE CONTRACTION 13 99 3.813e-05 0.0005345
333 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 8 38 3.963e-05 0.0005521
334 POSITIVE REGULATION OF ORGAN GROWTH 8 38 3.963e-05 0.0005521
335 CELLULAR RESPONSE TO NITROGEN COMPOUND 36 505 4.054e-05 0.0005631
336 REGULATION OF BODY FLUID LEVELS 36 506 4.224e-05 0.0005849
337 EMBRYONIC ORGAN MORPHOGENESIS 24 279 4.502e-05 0.0006216
338 ACTIN MEDIATED CELL CONTRACTION 11 74 4.698e-05 0.0006467
339 STEM CELL DIVISION 7 29 4.75e-05 0.00065
340 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 7 29 4.75e-05 0.00065
341 NEGATIVE CHEMOTAXIS 8 39 4.835e-05 0.0006598
342 EYELID DEVELOPMENT IN CAMERA TYPE EYE 5 13 5.096e-05 0.0006933
343 NEURAL CREST CELL DIFFERENTIATION 11 75 5.335e-05 0.0007237
344 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 117 5.548e-05 0.0007504
345 REGULATION OF BINDING 24 283 5.646e-05 0.0007615
346 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 38 554 5.713e-05 0.0007682
347 NEUROEPITHELIAL CELL DIFFERENTIATION 10 63 5.822e-05 0.0007807
348 CHONDROCYTE DEVELOPMENT 6 21 5.98e-05 0.0007968
349 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 7 30 6.011e-05 0.0007968
350 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 7 30 6.011e-05 0.0007968
351 SIALYLATION 6 21 5.98e-05 0.0007968
352 REGULATION OF TRANSPORTER ACTIVITY 19 198 6.472e-05 0.0008556
353 REGULATION OF PHOSPHOLIPASE ACTIVITY 10 64 6.688e-05 0.0008791
354 REGULATION OF NEUROTRANSMITTER TRANSPORT 10 64 6.688e-05 0.0008791
355 AORTA DEVELOPMENT 8 41 7.063e-05 0.0009258
356 REGULATION OF DENDRITE DEVELOPMENT 14 120 7.34e-05 0.0009593
357 METAL ION TRANSPORT 39 582 7.553e-05 0.0009844
358 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 5 14 7.701e-05 0.001001
359 INORGANIC ION TRANSMEMBRANE TRANSPORT 39 583 7.833e-05 0.001015
360 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 9 53 7.903e-05 0.001016
361 NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 53 7.903e-05 0.001016
362 SKELETAL MUSCLE CELL DIFFERENTIATION 9 53 7.903e-05 0.001016
363 CELL CELL SIGNALING INVOLVED IN CARDIAC CONDUCTION 6 22 7.982e-05 0.00102
364 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 6 22 7.982e-05 0.00102
365 CATION TRANSPORT 49 796 8.083e-05 0.00103
366 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 8 42 8.462e-05 0.001076
367 REGULATION OF SEQUESTERING OF CALCIUM ION 13 107 8.662e-05 0.001098
368 REGULATION OF CELL ACTIVATION 34 484 8.782e-05 0.00111
369 PEPTIDYL TYROSINE MODIFICATION 18 186 8.968e-05 0.001131
370 REGULATION OF ERK1 AND ERK2 CASCADE 21 238 9.237e-05 0.001159
371 POSITIVE REGULATION OF GROWTH 21 238 9.237e-05 0.001159
372 ENDOCARDIAL CUSHION DEVELOPMENT 7 32 9.355e-05 0.001164
373 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 7 32 9.355e-05 0.001164
374 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 23 274 9.352e-05 0.001164
375 HEMOSTASIS 25 311 9.47e-05 0.001175
376 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 6 23 0.0001048 0.001297
377 REGULATION OF SYNAPTIC PLASTICITY 15 140 0.0001097 0.001353
378 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 5 15 0.0001122 0.001381
379 ORGAN GROWTH 10 68 0.0001133 0.001388
380 NERVE DEVELOPMENT 10 68 0.0001133 0.001388
381 RESPONSE TO DRUG 31 431 0.0001165 0.001423
382 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 40 616 0.0001203 0.001466
383 EPITHELIAL TO MESENCHYMAL TRANSITION 9 56 0.0001231 0.001488
384 REGULATION OF DENDRITIC SPINE DEVELOPMENT 9 56 0.0001231 0.001488
385 OUTFLOW TRACT MORPHOGENESIS 9 56 0.0001231 0.001488
386 POSITIVE REGULATION OF AXONOGENESIS 10 69 0.0001285 0.001549
387 GLAND MORPHOGENESIS 12 97 0.0001349 0.001614
388 REGULATION OF TRANSFERASE ACTIVITY 55 946 0.0001346 0.001614
389 GLAND DEVELOPMENT 29 395 0.0001349 0.001614
390 LUNG MORPHOGENESIS 8 45 0.000141 0.001682
391 RESPONSE TO MECHANICAL STIMULUS 19 210 0.0001417 0.001686
392 PATTERN SPECIFICATION PROCESS 30 418 0.0001551 0.001841
393 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 16 0.0001586 0.001863
394 EXTRACELLULAR MATRIX ASSEMBLY 5 16 0.0001586 0.001863
395 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 5 16 0.0001586 0.001863
396 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 5 16 0.0001586 0.001863
397 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 12 99 0.0001642 0.001915
398 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 12 99 0.0001642 0.001915
399 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 12 99 0.0001642 0.001915
400 GLYCOSPHINGOLIPID BIOSYNTHETIC PROCESS 6 25 0.0001733 0.002011
401 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 6 25 0.0001733 0.002011
402 REGULATION OF CELLULAR LOCALIZATION 69 1277 0.0001751 0.002027
403 METENCEPHALON DEVELOPMENT 12 100 0.0001808 0.002083
404 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 12 100 0.0001808 0.002083
405 CELLULAR RESPONSE TO ALCOHOL 13 115 0.0001813 0.002083
406 REGULATION OF METAL ION TRANSPORT 25 325 0.0001887 0.002157
407 REGULATION OF HEART RATE 11 86 0.0001887 0.002157
408 REGULATION OF VASCULATURE DEVELOPMENT 20 233 0.000195 0.002224
409 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 13 116 0.0001978 0.002251
410 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 32 465 0.0002038 0.002313
411 POSITIVE REGULATION OF AXON EXTENSION 7 36 0.0002056 0.002322
412 SEMAPHORIN PLEXIN SIGNALING PATHWAY 7 36 0.0002056 0.002322
413 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 9 60 0.0002124 0.002393
414 RESPONSE TO KETONE 17 182 0.0002139 0.002404
415 GANGLIOSIDE METABOLIC PROCESS 6 26 0.0002187 0.002441
416 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 5 17 0.0002182 0.002441
417 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 6 26 0.0002187 0.002441
418 REGULATION OF HOMEOSTATIC PROCESS 31 447 0.0002228 0.00248
419 MYOFIBRIL ASSEMBLY 8 48 0.0002252 0.002501
420 REGULATION OF WNT SIGNALING PATHWAY 24 310 0.0002289 0.002535
421 REGULATION OF STEM CELL PROLIFERATION 11 88 0.0002318 0.002562
422 REGULATION OF CALCIUM ION IMPORT 12 103 0.0002395 0.002641
423 REGIONALIZATION 24 311 0.0002401 0.002641
424 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 7 37 0.0002461 0.0027
425 CELLULAR RESPONSE TO PEPTIDE 22 274 0.0002482 0.002717
426 REGULATION OF PROTEIN BINDING 16 168 0.0002606 0.002825
427 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 10 75 0.0002598 0.002825
428 REGULATION OF ORGANELLE ORGANIZATION 64 1178 0.0002608 0.002825
429 CELL GROWTH 14 135 0.0002594 0.002825
430 CARDIAC CELL DEVELOPMENT 8 49 0.000261 0.002825
431 MOTOR NEURON AXON GUIDANCE 6 27 0.000273 0.00292
432 REGULATION OF MUSCLE CELL DIFFERENTIATION 15 152 0.0002736 0.00292
433 REGULATION OF CATENIN IMPORT INTO NUCLEUS 6 27 0.000273 0.00292
434 SENSORY ORGAN MORPHOGENESIS 20 239 0.0002731 0.00292
435 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 42 684 0.0002728 0.00292
436 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 6 27 0.000273 0.00292
437 REGULATION OF INTRACELLULAR TRANSPORT 39 621 0.000287 0.003056
438 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 23 296 0.000291 0.003092
439 COLLAGEN FIBRIL ORGANIZATION 7 38 0.0002927 0.003102
440 GANGLIOSIDE BIOSYNTHETIC PROCESS 5 18 0.0002936 0.003104
441 NEGATIVE REGULATION OF CELL GROWTH 16 170 0.0002981 0.003145
442 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 8 50 0.0003014 0.003159
443 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 50 0.0003014 0.003159
444 ENDODERM FORMATION 8 50 0.0003014 0.003159
445 CALCIUM ION TRANSPORT 19 223 0.0003068 0.003208
446 REGULATION OF MUSCLE ADAPTATION 9 63 0.00031 0.003234
447 ENSHEATHMENT OF NEURONS 11 91 0.0003121 0.003241
448 AXON ENSHEATHMENT 11 91 0.0003121 0.003241
449 ACTOMYOSIN STRUCTURE ORGANIZATION 10 77 0.0003231 0.003341
450 DEVELOPMENTAL CELL GROWTH 10 77 0.0003231 0.003341
451 VENTRICULAR SEPTUM MORPHOGENESIS 6 28 0.0003374 0.003481
452 REGULATION OF AXON GUIDANCE 7 39 0.0003461 0.003531
453 ARTERY MORPHOGENESIS 8 51 0.0003468 0.003531
454 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 11 92 0.0003436 0.003531
455 REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 8 51 0.0003468 0.003531
456 LONG TERM SYNAPTIC POTENTIATION 7 39 0.0003461 0.003531
457 NEGATIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 7 39 0.0003461 0.003531
458 RENAL TUBULE DEVELOPMENT 10 78 0.0003593 0.00365
459 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 18 208 0.0003627 0.003677
460 REGULATION OF CYTOPLASMIC TRANSPORT 32 481 0.0003703 0.003746
461 MUCOPOLYSACCHARIDE METABOLIC PROCESS 12 108 0.0003732 0.003767
462 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 11 93 0.0003776 0.003795
463 NEPHRON EPITHELIUM DEVELOPMENT 11 93 0.0003776 0.003795
464 REGULATION OF CALCIUM ION TRANSPORT 18 209 0.0003844 0.003854
465 VENTRICULAR CARDIAC MUSCLE CELL DIFFERENTIATION 5 19 0.0003871 0.003865
466 REGULATION OF CARDIAC MUSCLE CONTRACTION BY REGULATION OF THE RELEASE OF SEQUESTERED CALCIUM ION 5 19 0.0003871 0.003865
467 CHEMICAL HOMEOSTASIS 50 874 0.0003926 0.003912
468 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 8 52 0.0003975 0.003952
469 REGULATION OF NEURON APOPTOTIC PROCESS 17 192 0.0004016 0.003976
470 PROTEIN AUTOPHOSPHORYLATION 17 192 0.0004016 0.003976
471 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 6 29 0.000413 0.004078
472 RESPONSE TO BMP 11 94 0.0004145 0.004078
473 CELLULAR RESPONSE TO BMP STIMULUS 11 94 0.0004145 0.004078
474 MEMBRANE ORGANIZATION 51 899 0.0004177 0.0041
475 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 8 53 0.0004541 0.004439
476 MESONEPHRIC TUBULE MORPHOGENESIS 8 53 0.0004541 0.004439
477 LUNG ALVEOLUS DEVELOPMENT 7 41 0.0004764 0.004647
478 EAR DEVELOPMENT 17 195 0.0004804 0.004676
479 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 28 406 0.0004819 0.004677
480 MULTI MULTICELLULAR ORGANISM PROCESS 18 213 0.0004825 0.004677
481 REGULATION OF HOMOTYPIC CELL CELL ADHESION 23 307 0.0004872 0.004713
482 SMOOTH MUSCLE CELL DIFFERENTIATION 6 30 0.0005012 0.004791
483 CYTOSKELETON ORGANIZATION 48 838 0.0004975 0.004791
484 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 5 20 0.0005014 0.004791
485 NEGATIVE REGULATION OF CELL MATRIX ADHESION 6 30 0.0005012 0.004791
486 RELAXATION OF MUSCLE 5 20 0.0005014 0.004791
487 MELANOCYTE DIFFERENTIATION 5 20 0.0005014 0.004791
488 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 14 144 0.0005034 0.0048
489 REGULATION OF NEURON DEATH 20 252 0.000541 0.005148
490 DENDRITE MORPHOGENESIS 7 42 0.0005548 0.005268
491 NEGATIVE REGULATION OF DENDRITIC SPINE DEVELOPMENT 4 12 0.0005725 0.005393
492 NEURON PROJECTION EXTENSION INVOLVED IN NEURON PROJECTION GUIDANCE 4 12 0.0005725 0.005393
493 CARTILAGE MORPHOGENESIS 4 12 0.0005725 0.005393
494 AXON EXTENSION INVOLVED IN AXON GUIDANCE 4 12 0.0005725 0.005393
495 RESPONSE TO OXYGEN LEVELS 23 311 0.0005829 0.005479
496 REGULATION OF KIDNEY DEVELOPMENT 8 55 0.000587 0.005495
497 CRANIAL SKELETAL SYSTEM DEVELOPMENT 8 55 0.000587 0.005495
498 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 11 98 0.0005937 0.005546
499 REGULATION OF LIPASE ACTIVITY 10 83 0.0005947 0.005546
500 CARDIAC ATRIUM DEVELOPMENT 6 31 0.0006034 0.005604
501 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 6 31 0.0006034 0.005604
502 NEGATIVE REGULATION OF OSSIFICATION 9 69 0.000617 0.005719
503 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 0.0006198 0.005733
504 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 18 218 0.000635 0.005863
505 NEGATIVE REGULATION OF ORGAN GROWTH 5 21 0.0006394 0.00588
506 POSITIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 5 21 0.0006394 0.00588
507 RESPONSE TO STEROID HORMONE 32 497 0.0006481 0.005948
508 PEPTIDYL SERINE MODIFICATION 14 148 0.0006628 0.006071
509 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 9 70 0.0006866 0.006277
510 LIMBIC SYSTEM DEVELOPMENT 11 100 0.000705 0.006432
511 SALIVARY GLAND DEVELOPMENT 6 32 0.0007211 0.00649
512 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 6 32 0.0007211 0.00649
513 PALATE DEVELOPMENT 10 85 0.0007191 0.00649
514 NEGATIVE REGULATION OF TRANSPORT 30 458 0.0007181 0.00649
515 REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 6 32 0.0007211 0.00649
516 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 16 184 0.0007161 0.00649
517 ADIPOSE TISSUE DEVELOPMENT 6 32 0.0007211 0.00649
518 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 58 1087 0.0007844 0.007046
519 SUBSTRATE INDEPENDENT TELENCEPHALIC TANGENTIAL INTERNEURON MIGRATION 4 13 0.0008043 0.007115
520 NEGATIVE REGULATION OF MUSCLE CONTRACTION 5 22 0.000804 0.007115
521 REGULATION OF RESPIRATORY GASEOUS EXCHANGE BY NEUROLOGICAL SYSTEM PROCESS 4 13 0.0008043 0.007115
522 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 13 0.0008043 0.007115
523 ASYMMETRIC CELL DIVISION 4 13 0.0008043 0.007115
524 SUBSTRATE INDEPENDENT TELENCEPHALIC TANGENTIAL MIGRATION 4 13 0.0008043 0.007115
525 CARDIOBLAST DIFFERENTIATION 4 13 0.0008043 0.007115
526 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 4 13 0.0008043 0.007115
527 CELL ACTIVATION 35 568 0.0008109 0.007159
528 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 51 926 0.0008128 0.007162
529 REGULATION OF MAP KINASE ACTIVITY 23 319 0.0008245 0.007252
530 RENAL SYSTEM PROCESS 11 102 0.0008332 0.007315
531 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 153 0.0009203 0.008065
532 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 37 616 0.0009273 0.00811
533 SYNAPTIC SIGNALING 28 424 0.0009422 0.008225
534 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 27 404 0.000967 0.008426
535 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 46 0.0009762 0.00849
536 ESTABLISHMENT OF EPITHELIAL CELL POLARITY 5 23 0.0009982 0.008634
537 STRIATED MUSCLE ADAPTATION 5 23 0.0009982 0.008634
538 INNERVATION 5 23 0.0009982 0.008634
539 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 34 0.001009 0.008672
540 RESPONSE TO FLUID SHEAR STRESS 6 34 0.001009 0.008672
541 REGULATION OF MESENCHYMAL CELL PROLIFERATION 6 34 0.001009 0.008672
542 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 16 190 0.00101 0.008672
543 CELL CELL JUNCTION ASSEMBLY 9 74 0.001032 0.008843
544 NEUROTRANSMITTER TRANSPORT 14 155 0.001045 0.008919
545 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 25 365 0.001043 0.008919
546 CELL MIGRATION INVOLVED IN HEART DEVELOPMENT 4 14 0.001095 0.009317
547 RESPONSE TO LAMINAR FLUID SHEAR STRESS 4 14 0.001095 0.009317
548 REGULATION OF ACTIN FILAMENT LENGTH 14 156 0.001112 0.009441
549 CALCIUM MEDIATED SIGNALING 10 90 0.001126 0.009527
550 ENDOTHELIUM DEVELOPMENT 10 90 0.001126 0.009527
551 ACTIN FILAMENT ORGANIZATION 15 174 0.001133 0.009566
552 SPINAL CORD DEVELOPMENT 11 106 0.001148 0.009675
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 59 629 4.327e-12 4.02e-09
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 86 1199 1.095e-10 5.087e-08
3 REGULATORY REGION NUCLEIC ACID BINDING 66 818 1.693e-10 5.242e-08
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 37 328 3.184e-10 7.394e-08
5 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 35 315 1.447e-09 2.688e-07
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 20 133 3.464e-08 5.363e-06
7 GROWTH FACTOR BINDING 19 123 4.882e-08 6.479e-06
8 CYTOSKELETAL PROTEIN BINDING 59 819 9.928e-08 9.223e-06
9 PROTEIN KINASE ACTIVITY 50 640 8.496e-08 9.223e-06
10 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 26 226 9.379e-08 9.223e-06
11 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 26 228 1.12e-07 9.458e-06
12 ACTIN BINDING 36 393 1.316e-07 1.019e-05
13 SEQUENCE SPECIFIC DNA BINDING 68 1037 3.548e-07 2.535e-05
14 ACTIVATING TRANSCRIPTION FACTOR BINDING 12 57 4.752e-07 3.153e-05
15 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 36 417 5.581e-07 3.389e-05
16 MACROMOLECULAR COMPLEX BINDING 84 1399 5.837e-07 3.389e-05
17 DOUBLE STRANDED DNA BINDING 54 764 6.412e-07 3.504e-05
18 CATION CHANNEL ACTIVITY 28 298 1.987e-06 0.0001025
19 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 28 303 2.749e-06 0.0001344
20 CYTOKINE BINDING 14 92 3.377e-06 0.0001494
21 ENZYME BINDING 96 1737 3.334e-06 0.0001494
22 RECEPTOR BINDING 84 1476 4.896e-06 0.0002067
23 KINASE ACTIVITY 55 842 5.521e-06 0.000223
24 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 36 464 6.567e-06 0.0002542
25 PROTEIN DOMAIN SPECIFIC BINDING 44 624 7.582e-06 0.0002817
26 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 42 588 8.946e-06 0.0003197
27 VOLTAGE GATED ION CHANNEL ACTIVITY 20 190 1.088e-05 0.0003744
28 CALCIUM ION BINDING 47 697 1.199e-05 0.000384
29 SH3 DOMAIN BINDING 15 116 1.19e-05 0.000384
30 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 13 90 1.349e-05 0.0004176
31 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 38 527 1.937e-05 0.0005805
32 PROTEIN COMPLEX BINDING 57 935 2.787e-05 0.0008091
33 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 42 622 3.38e-05 0.0009515
34 MOLECULAR FUNCTION REGULATOR 75 1353 3.973e-05 0.001086
35 CORE PROMOTER PROXIMAL REGION DNA BINDING 29 371 4.472e-05 0.001187
36 TRANSMEMBRANE TRANSPORTER ACTIVITY 59 997 4.698e-05 0.001212
37 EXTRACELLULAR MATRIX BINDING 9 51 5.772e-05 0.001449
38 SIALYLTRANSFERASE ACTIVITY 6 21 5.98e-05 0.001462
39 DIVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 17 167 7.467e-05 0.001737
40 GATED CHANNEL ACTIVITY 26 325 7.481e-05 0.001737
41 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 17 168 8.045e-05 0.001779
42 ACTIN FILAMENT BINDING 14 121 8.04e-05 0.001779
43 CELL ADHESION MOLECULE BINDING 18 186 8.968e-05 0.001938
44 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 11 81 0.0001094 0.002309
45 PROTEIN TYROSINE KINASE ACTIVITY 17 176 0.0001427 0.002946
46 TRANSFORMING GROWTH FACTOR BETA BINDING 5 16 0.0001586 0.003202
47 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 11 86 0.0001887 0.003729
48 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 56 992 0.0002483 0.004806
49 TRANSPORTER ACTIVITY 68 1276 0.0002887 0.005473
50 KINASE BINDING 38 606 0.0003523 0.006418
51 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 9 64 0.0003497 0.006418
52 HEPARIN BINDING 15 157 0.0003881 0.006752
53 TRANSCRIPTION FACTOR BINDING 34 524 0.0003874 0.006752
54 SEMAPHORIN RECEPTOR ACTIVITY 4 11 0.0003924 0.006752
55 PROTEIN SERINE THREONINE KINASE ACTIVITY 30 445 0.0004492 0.007587
56 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 5 20 0.0005014 0.008318
57 CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 13 128 0.0005209 0.00849
58 TUBULIN BINDING 21 273 0.0005991 0.009596
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 135 1786 1.892e-18 1.105e-15
2 CELL JUNCTION 97 1151 3.065e-16 8.951e-14
3 NEURON PROJECTION 82 942 1.348e-14 2.625e-12
4 NEURON PART 98 1265 4.462e-14 6.515e-12
5 SYNAPSE 61 754 7.848e-10 8.265e-08
6 CELL SURFACE 61 757 9.16e-10 8.265e-08
7 SOMATODENDRITIC COMPARTMENT 55 650 1.128e-09 8.265e-08
8 MEMBRANE REGION 80 1134 1.141e-09 8.265e-08
9 PLASMA MEMBRANE PROTEIN COMPLEX 47 510 1.274e-09 8.265e-08
10 SARCOLEMMA 21 125 2.04e-09 1.083e-07
11 CELL LEADING EDGE 37 350 1.961e-09 1.083e-07
12 CELL SUBSTRATE JUNCTION 39 398 6.202e-09 3.018e-07
13 ACTIN CYTOSKELETON 41 444 1.399e-08 6.285e-07
14 ANCHORING JUNCTION 43 489 2.593e-08 1.082e-06
15 PROTEINACEOUS EXTRACELLULAR MATRIX 34 356 1.092e-07 4.253e-06
16 DENDRITE 39 451 1.803e-07 6.582e-06
17 EXTRACELLULAR MATRIX 37 426 3.348e-07 1.15e-05
18 INTRINSIC COMPONENT OF PLASMA MEMBRANE 95 1649 6.321e-07 2.051e-05
19 CELL BODY 40 494 6.944e-07 2.134e-05
20 CYTOSKELETON 108 1967 9.999e-07 2.92e-05
21 CELL PROJECTION PART 62 946 1.223e-06 3.402e-05
22 SYNAPSE PART 45 610 1.83e-06 4.858e-05
23 GOLGI APPARATUS 84 1445 2.146e-06 5.449e-05
24 T TUBULE 10 45 2.553e-06 6.212e-05
25 SITE OF POLARIZED GROWTH 18 149 4.383e-06 0.0001024
26 I BAND 16 121 4.574e-06 0.0001027
27 PLASMA MEMBRANE REGION 59 929 5.94e-06 0.0001285
28 MEMBRANE MICRODOMAIN 26 288 9.419e-06 0.0001964
29 CELL CELL JUNCTION 31 383 1.249e-05 0.0002516
30 POSTSYNAPSE 30 378 2.497e-05 0.000486
31 EXTRACELLULAR MATRIX COMPONENT 15 125 2.937e-05 0.0005533
32 LAMELLIPODIUM 18 172 3.205e-05 0.0005671
33 RECEPTOR COMPLEX 27 327 3.171e-05 0.0005671
34 SIDE OF MEMBRANE 32 428 4.369e-05 0.0007504
35 CONTRACTILE FIBER 20 211 4.991e-05 0.0008328
36 GOLGI APPARATUS PART 54 893 5.633e-05 0.0009138
37 AXON 31 418 6.658e-05 0.001051
38 CATION CHANNEL COMPLEX 17 167 7.467e-05 0.001148
39 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 7.701e-05 0.001153
40 PODOSOME 6 23 0.0001048 0.001531
41 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 12 98 0.000149 0.002122
42 SODIUM CHANNEL COMPLEX 5 17 0.0002182 0.003034
43 MEMBRANE PROTEIN COMPLEX 57 1020 0.0002827 0.003839
44 NEURON SPINE 13 121 0.0003012 0.003998
45 RUFFLE 15 156 0.0003624 0.004703
46 PLATELET DENSE TUBULAR NETWORK 4 11 0.0003924 0.004876
47 SEMAPHORIN RECEPTOR COMPLEX 4 11 0.0003924 0.004876
48 FILOPODIUM 11 94 0.0004145 0.004941
49 PRESYNAPTIC ACTIVE ZONE 6 29 0.000413 0.004941
50 EXTRACELLULAR SPACE 71 1376 0.0005297 0.006187
51 ACTIN BASED CELL PROJECTION 16 181 0.0005988 0.006857
52 ACTIN FILAMENT 9 70 0.0006866 0.007711
53 CYTOPLASMIC SIDE OF MEMBRANE 15 170 0.0008938 0.009525
54 GOLGI MEMBRANE 41 703 0.0008912 0.009525
55 TRANSPORTER COMPLEX 23 321 0.000897 0.009525
56 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 13 136 0.0009249 0.009645

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 25 200 3.21e-08 5.778e-06
2 hsa04540_Gap_junction 15 90 4.562e-07 4.106e-05
3 hsa04151_PI3K_AKT_signaling_pathway 32 351 7.282e-07 4.369e-05
4 hsa04810_Regulation_of_actin_cytoskeleton 23 214 1.697e-06 7.638e-05
5 hsa04010_MAPK_signaling_pathway 26 268 2.546e-06 9.166e-05
6 hsa04514_Cell_adhesion_molecules_.CAMs. 17 136 5.053e-06 0.0001516
7 hsa04270_Vascular_smooth_muscle_contraction 15 116 1.19e-05 0.000306
8 hsa04390_Hippo_signaling_pathway 17 154 2.657e-05 0.0005519
9 hsa04014_Ras_signaling_pathway 22 236 2.759e-05 0.0005519
10 hsa04512_ECM.receptor_interaction 12 85 3.637e-05 0.0006546
11 hsa04971_Gastric_acid_secretion 11 74 4.698e-05 0.0007687
12 hsa04720_Long.term_potentiation 10 70 0.0001453 0.002179
13 hsa04020_Calcium_signaling_pathway 16 177 0.0004683 0.006485
14 hsa04360_Axon_guidance 13 130 0.0006043 0.007769
15 hsa04730_Long.term_depression 9 70 0.0006866 0.008239
16 hsa04912_GnRH_signaling_pathway 11 101 0.0007669 0.008628
17 hsa04012_ErbB_signaling_pathway 10 87 0.0008642 0.00915
18 hsa04970_Salivary_secretion 10 89 0.001032 0.01032
19 hsa04722_Neurotrophin_signaling_pathway 12 127 0.001586 0.01502
20 hsa04916_Melanogenesis 10 101 0.002693 0.02353
21 hsa04350_TGF.beta_signaling_pathway 9 85 0.002745 0.02353
22 hsa04520_Adherens_junction 8 73 0.003756 0.03073
23 hsa04630_Jak.STAT_signaling_pathway 12 155 0.007994 0.06256
24 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 4 26 0.01176 0.08819
25 hsa04380_Osteoclast_differentiation 10 128 0.0139 0.09631
26 hsa00604_Glycosphingolipid_biosynthesis_._ganglio_series 3 15 0.01391 0.09631
27 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 3 22 0.03937 0.2625
28 hsa04710_Circadian_rhythm_._mammal 3 23 0.04414 0.2837
29 hsa04666_Fc_gamma_R.mediated_phagocytosis 7 95 0.04749 0.2948
30 hsa04320_Dorso.ventral_axis_formation 3 25 0.0545 0.327
31 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 0.05717 0.332
32 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 3 26 0.06007 0.3379
33 hsa04972_Pancreatic_secretion 7 101 0.06214 0.339
34 hsa04962_Vasopressin.regulated_water_reabsorption 4 44 0.06574 0.3481
35 hsa04310_Wnt_signaling_pathway 9 151 0.081 0.4166
36 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 2 15 0.09395 0.4698
37 hsa04144_Endocytosis 11 203 0.09753 0.4745
38 hsa04670_Leukocyte_transendothelial_migration 7 117 0.1133 0.5368
39 hsa04614_Renin.angiotensin_system 2 17 0.1164 0.537
40 hsa04260_Cardiac_muscle_contraction 5 77 0.1296 0.5693
41 hsa04340_Hedgehog_signaling_pathway 4 56 0.1297 0.5693
42 hsa04070_Phosphatidylinositol_signaling_system 5 78 0.1348 0.5778
43 hsa00760_Nicotinate_and_nicotinamide_metabolism 2 24 0.2023 0.8186
44 hsa04910_Insulin_signaling_pathway 7 138 0.2049 0.8186
45 hsa04114_Oocyte_meiosis 6 114 0.2055 0.8186
46 hsa04062_Chemokine_signaling_pathway 9 189 0.2126 0.8186
47 hsa00514_Other_types_of_O.glycan_biosynthesis 3 46 0.2142 0.8186
48 hsa04115_p53_signaling_pathway 4 69 0.2183 0.8186
49 hsa04976_Bile_secretion 4 71 0.2332 0.8566
50 hsa04145_Phagosome 7 156 0.2996 1
51 hsa04974_Protein_digestion_and_absorption 4 81 0.3105 1
52 hsa04530_Tight_junction 6 133 0.3166 1
53 hsa04660_T_cell_receptor_signaling_pathway 5 108 0.322 1
54 hsa00230_Purine_metabolism 7 162 0.3331 1
55 hsa04130_SNARE_interactions_in_vesicular_transport 2 36 0.3574 1
56 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.358 1
57 hsa04640_Hematopoietic_cell_lineage 4 88 0.366 1
58 hsa04210_Apoptosis 4 89 0.3739 1
59 hsa00600_Sphingolipid_metabolism 2 40 0.4072 1
60 hsa04920_Adipocytokine_signaling_pathway 3 68 0.4224 1
61 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.4551 1
62 hsa04330_Notch_signaling_pathway 2 47 0.4895 1
63 hsa04370_VEGF_signaling_pathway 3 76 0.4949 1
64 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.5209 1
65 hsa04150_mTOR_signaling_pathway 2 52 0.5438 1
66 hsa04742_Taste_transduction 2 52 0.5438 1
67 hsa04142_Lysosome 4 121 0.6101 1
68 hsa04110_Cell_cycle 4 128 0.654 1
69 hsa04610_Complement_and_coagulation_cascades 2 69 0.697 1
70 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.7398 1
71 hsa04612_Antigen_processing_and_presentation 2 78 0.7593 1
72 hsa04650_Natural_killer_cell_mediated_cytotoxicity 3 136 0.8559 1
73 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.9565 1
74 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.9818 1
75 hsa04740_Olfactory_transduction 3 388 0.9999 1

Quest ID: 81237c95a9bd282c562553e410ccaf04