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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p IGF2BP3 -0.21 0.00725 0.68 0.00052 MirTarget; TargetScan -0.46 0 NA
2 hsa-let-7b-5p IGF2BP3 -0.54 0 0.68 0.00052 miRNAWalker2 validate; MirTarget -0.41 0 NA
3 hsa-let-7c-5p IGF2BP3 -1.94 0 0.68 0.00052 MirTarget -0.19 7.0E-5 NA
4 hsa-miR-125a-5p IGF2BP3 -0.64 0 0.68 0.00052 miRanda -0.27 8.0E-5 NA
5 hsa-miR-34c-5p IGF2BP3 -0.09 0.55702 0.68 0.00052 miRanda -0.22 0 NA
6 hsa-miR-542-3p IGF2BP3 0.57 0 0.68 0.00052 miRanda -0.12 0.04618 NA
7 hsa-miR-664a-3p IGF2BP3 -0.24 0.01971 0.68 0.00052 MirTarget -0.25 0.00012 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 26 1518 8.14e-12 3.787e-08
2 RESPONSE TO ESTRADIOL 10 146 1.321e-10 2.049e-07
3 REGULATION OF PROTEIN MODIFICATION PROCESS 26 1710 1.155e-10 2.049e-07
4 EPITHELIUM DEVELOPMENT 19 945 7.699e-10 7.408e-07
5 REGULATION OF MAPK CASCADE 16 660 1.514e-09 7.408e-07
6 NEGATIVE REGULATION OF KINASE ACTIVITY 11 250 1.679e-09 7.408e-07
7 OSSIFICATION 11 251 1.751e-09 7.408e-07
8 UROGENITAL SYSTEM DEVELOPMENT 12 299 8.155e-10 7.408e-07
9 GLAND DEVELOPMENT 13 395 1.688e-09 7.408e-07
10 REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 1618 1.271e-09 7.408e-07
11 REGULATION OF CELL PROLIFERATION 23 1496 1.581e-09 7.408e-07
12 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 20 1135 2.452e-09 9.509e-07
13 NEGATIVE REGULATION OF MAPK CASCADE 9 145 2.821e-09 1.01e-06
14 TISSUE MORPHOGENESIS 14 533 6.721e-09 1.646e-06
15 REGULATION OF TRANSFERASE ACTIVITY 18 946 5.603e-09 1.646e-06
16 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 13 437 5.685e-09 1.646e-06
17 ORGAN MORPHOGENESIS 17 841 6.606e-09 1.646e-06
18 RESPONSE TO ESTROGEN 10 218 6.574e-09 1.646e-06
19 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 5.663e-09 1.646e-06
20 POSITIVE REGULATION OF RESPONSE TO STIMULUS 25 1929 8.204e-09 1.907e-06
21 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1492 8.606e-09 1.907e-06
22 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 21 1360 9.256e-09 1.958e-06
23 TUBE DEVELOPMENT 14 552 1.047e-08 2.118e-06
24 HEART DEVELOPMENT 13 466 1.221e-08 2.367e-06
25 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 23 1672 1.321e-08 2.418e-06
26 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 470 1.351e-08 2.418e-06
27 CELLULAR GLUCURONIDATION 5 22 1.414e-08 2.437e-06
28 REGULATION OF KINASE ACTIVITY 16 776 1.508e-08 2.505e-06
29 INOSITOL LIPID MEDIATED SIGNALING 8 124 1.668e-08 2.676e-06
30 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 18 1036 2.285e-08 3.43e-06
31 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 18 1036 2.285e-08 3.43e-06
32 TUBE MORPHOGENESIS 11 323 2.4e-08 3.49e-06
33 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 8 131 2.568e-08 3.622e-06
34 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 2.829e-08 3.872e-06
35 POSITIVE REGULATION OF CELL PROLIFERATION 16 814 2.938e-08 3.906e-06
36 NEGATIVE REGULATION OF PHOSPHORYLATION 12 422 3.832e-08 4.953e-06
37 GLUCURONATE METABOLIC PROCESS 5 27 4.274e-08 5.234e-06
38 URONIC ACID METABOLIC PROCESS 5 27 4.274e-08 5.234e-06
39 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 18 1087 4.757e-08 5.676e-06
40 FLAVONOID METABOLIC PROCESS 5 28 5.189e-08 6.036e-06
41 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 11 351 5.605e-08 6.36e-06
42 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 24 1977 6.429e-08 7.122e-06
43 CELL PROLIFERATION 14 672 1.208e-07 1.278e-05
44 REGULATION OF MITOTIC CELL CYCLE 12 468 1.181e-07 1.278e-05
45 CARDIOVASCULAR SYSTEM DEVELOPMENT 15 788 1.294e-07 1.309e-05
46 CIRCULATORY SYSTEM DEVELOPMENT 15 788 1.294e-07 1.309e-05
47 MESODERM MORPHOGENESIS 6 66 1.465e-07 1.451e-05
48 FORMATION OF PRIMARY GERM LAYER 7 110 1.517e-07 1.471e-05
49 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 14 1.59e-07 1.51e-05
50 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 14 689 1.64e-07 1.526e-05
51 MORPHOGENESIS OF A BRANCHING STRUCTURE 8 167 1.693e-07 1.545e-05
52 MORPHOGENESIS OF AN EPITHELIUM 11 400 2.09e-07 1.87e-05
53 RESPONSE TO STEROID HORMONE 12 497 2.256e-07 1.944e-05
54 PROTEIN PHOSPHORYLATION 16 944 2.238e-07 1.944e-05
55 MAMMARY GLAND DEVELOPMENT 7 117 2.317e-07 1.96e-05
56 REGULATION OF CELL CYCLE 16 949 2.403e-07 1.965e-05
57 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 13 602 2.408e-07 1.965e-05
58 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 21 1656 2.715e-07 2.178e-05
59 KIDNEY EPITHELIUM DEVELOPMENT 7 125 3.64e-07 2.871e-05
60 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 4 17 3.75e-07 2.884e-05
61 PROSTATE GLAND DEVELOPMENT 5 41 3.813e-07 2.884e-05
62 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 126 3.843e-07 2.884e-05
63 RENAL TUBULE DEVELOPMENT 6 78 4.002e-07 2.956e-05
64 REGULATION OF GROWTH 13 633 4.262e-07 3.099e-05
65 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 5 44 5.479e-07 3.7e-05
66 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 541 5.566e-07 3.7e-05
67 EMBRYONIC MORPHOGENESIS 12 539 5.352e-07 3.7e-05
68 KIDNEY MORPHOGENESIS 6 82 5.394e-07 3.7e-05
69 CELL DEVELOPMENT 19 1426 5.561e-07 3.7e-05
70 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 12 541 5.566e-07 3.7e-05
71 EMBRYO DEVELOPMENT 15 894 6.484e-07 4.133e-05
72 GLIAL CELL DIFFERENTIATION 7 136 6.454e-07 4.133e-05
73 REGULATION OF CELLULAR COMPONENT MOVEMENT 14 771 6.368e-07 4.133e-05
74 SKELETAL SYSTEM DEVELOPMENT 11 455 7.487e-07 4.668e-05
75 RESPONSE TO ALCOHOL 10 362 7.524e-07 4.668e-05
76 ANTERIOR POSTERIOR AXIS SPECIFICATION 5 48 8.542e-07 5.23e-05
77 RESPONSE TO ORGANIC CYCLIC COMPOUND 15 917 8.924e-07 5.392e-05
78 REGULATION OF EPITHELIAL CELL PROLIFERATION 9 285 9.338e-07 5.521e-05
79 MESONEPHROS DEVELOPMENT 6 90 9.373e-07 5.521e-05
80 REGULATION OF CELL DIFFERENTIATION 19 1492 1.103e-06 6.417e-05
81 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 21 1805 1.124e-06 6.455e-05
82 NEPHRON EPITHELIUM DEVELOPMENT 6 93 1.138e-06 6.455e-05
83 NEGATIVE REGULATION OF MOLECULAR FUNCTION 16 1079 1.325e-06 7.427e-05
84 MAMMARY GLAND EPITHELIUM DEVELOPMENT 5 53 1.411e-06 7.726e-05
85 MESONEPHRIC TUBULE MORPHOGENESIS 5 53 1.411e-06 7.726e-05
86 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 1.49e-06 7.986e-05
87 PHOSPHORYLATION 17 1228 1.493e-06 7.986e-05
88 GASTRULATION 7 155 1.556e-06 8.227e-05
89 POSITIVE REGULATION OF CELL COMMUNICATION 19 1532 1.64e-06 8.479e-05
90 BONE DEVELOPMENT 7 156 1.624e-06 8.479e-05
91 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 11 498 1.805e-06 9.23e-05
92 NEGATIVE REGULATION OF CELL DIFFERENTIATION 12 609 1.923e-06 9.726e-05
93 REGULATION OF CATABOLIC PROCESS 13 731 2.13e-06 0.0001066
94 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 616 2.165e-06 0.0001071
95 REPRODUCTIVE SYSTEM DEVELOPMENT 10 408 2.21e-06 0.0001082
96 MESODERMAL CELL DIFFERENTIATION 4 26 2.298e-06 0.0001114
97 INTRACELLULAR SIGNAL TRANSDUCTION 19 1572 2.406e-06 0.0001154
98 REGULATION OF GLUCOSE IMPORT 5 60 2.633e-06 0.000125
99 REGULATION OF CELL ADHESION 12 629 2.685e-06 0.0001262
100 NEGATIVE REGULATION OF CELL DEATH 14 872 2.718e-06 0.0001265
101 REPRODUCTION 17 1297 3.141e-06 0.0001447
102 POSITIVE REGULATION OF CELL CYCLE 9 332 3.279e-06 0.0001496
103 RESPONSE TO LIPID 14 888 3.356e-06 0.0001507
104 NEGATIVE REGULATION OF CELL PROLIFERATION 12 643 3.367e-06 0.0001507
105 GLIOGENESIS 7 175 3.489e-06 0.0001546
106 RESPONSE TO HORMONE 14 893 3.582e-06 0.0001572
107 NEPHRON DEVELOPMENT 6 115 3.942e-06 0.0001714
108 POSITIVE REGULATION OF MOLECULAR FUNCTION 20 1791 4.103e-06 0.0001768
109 RESPONSE TO EXTRACELLULAR STIMULUS 10 441 4.409e-06 0.0001882
110 MESODERM DEVELOPMENT 6 118 4.577e-06 0.0001936
111 CELLULAR RESPONSE TO HORMONE STIMULUS 11 552 4.847e-06 0.0002032
112 PERIPHERAL NERVOUS SYSTEM DEVELOPMENT 5 69 5.283e-06 0.0002195
113 REGULATION OF CELL CYCLE PROCESS 11 558 5.372e-06 0.0002212
114 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 5.551e-06 0.0002246
115 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 9 354 5.518e-06 0.0002246
116 POSITIVE REGULATION OF MITOTIC CELL CYCLE 6 123 5.819e-06 0.0002314
117 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 13 801 5.78e-06 0.0002314
118 PROTEIN DEPHOSPHORYLATION 7 190 6e-06 0.0002366
119 RESPONSE TO NUTRIENT 7 191 6.21e-06 0.0002428
120 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 20 1848 6.595e-06 0.0002557
121 NEGATIVE REGULATION OF MAP KINASE ACTIVITY 5 73 6.981e-06 0.0002662
122 PROTEIN KINASE B SIGNALING 4 34 6.972e-06 0.0002662
123 REGULATION OF REPRODUCTIVE PROCESS 6 129 7.656e-06 0.0002896
124 REGULATION OF GLYCOGEN METABOLIC PROCESS 4 35 7.85e-06 0.0002945
125 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 7.924e-06 0.000295
126 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 13 829 8.367e-06 0.000309
127 NEUROGENESIS 17 1402 8.874e-06 0.0003226
128 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 4 36 8.806e-06 0.0003226
129 MONOSACCHARIDE METABOLIC PROCESS 7 202 8.958e-06 0.0003231
130 POSITIVE REGULATION OF GENE EXPRESSION 19 1733 9.96e-06 0.000356
131 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 3 12 1.002e-05 0.000356
132 GERM CELL DEVELOPMENT 7 209 1.118e-05 0.0003942
133 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 138 1.127e-05 0.0003943
134 METANEPHROS DEVELOPMENT 5 81 1.164e-05 0.0004042
135 HEART MORPHOGENESIS 7 212 1.227e-05 0.0004228
136 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 82 1.236e-05 0.0004229
137 MULTI MULTICELLULAR ORGANISM PROCESS 7 213 1.265e-05 0.0004295
138 POSITIVE REGULATION OF CATABOLIC PROCESS 9 395 1.328e-05 0.0004477
139 MAMMARY GLAND MORPHOGENESIS 4 40 1.351e-05 0.0004524
140 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 11 616 1.361e-05 0.0004524
141 RESPONSE TO ENDOGENOUS STIMULUS 17 1450 1.38e-05 0.0004553
142 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 14 1008 1.425e-05 0.0004667
143 CENTRAL NERVOUS SYSTEM DEVELOPMENT 13 872 1.434e-05 0.0004667
144 CELLULAR RESPONSE TO ESTROGEN STIMULUS 4 41 1.493e-05 0.0004825
145 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 1.646e-05 0.0005243
146 REGULATION OF CELL DEATH 17 1472 1.678e-05 0.0005243
147 RESPONSE TO TRANSITION METAL NANOPARTICLE 6 148 1.679e-05 0.0005243
148 BONE MATURATION 3 14 1.65e-05 0.0005243
149 MALE SEX DIFFERENTIATION 6 148 1.679e-05 0.0005243
150 NEURAL TUBE DEVELOPMENT 6 149 1.744e-05 0.0005411
151 MULTI ORGANISM REPRODUCTIVE PROCESS 13 891 1.801e-05 0.000554
152 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 4 43 1.81e-05 0.000554
153 AXIS SPECIFICATION 5 90 1.947e-05 0.000592
154 REGULATION OF MAP KINASE ACTIVITY 8 319 2.096e-05 0.0006334
155 NEGATIVE REGULATION OF GROWTH 7 236 2.45e-05 0.0007353
156 POSITIVE REGULATION OF CATALYTIC ACTIVITY 17 1518 2.496e-05 0.0007446
157 GLAND MORPHOGENESIS 5 97 2.799e-05 0.0008288
158 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 48 2.814e-05 0.0008288
159 DEVELOPMENTAL GROWTH 8 333 2.849e-05 0.0008337
160 REGULATION OF NUCLEAR DIVISION 6 163 2.898e-05 0.0008427
161 NEGATIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 17 3.058e-05 0.0008838
162 REGULATION OF EPITHELIAL CELL MIGRATION 6 166 3.21e-05 0.0009142
163 REGULATION OF GLUCOSE TRANSPORT 5 100 3.242e-05 0.0009142
164 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 100 3.242e-05 0.0009142
165 PEPTIDYL TYROSINE DEPHOSPHORYLATION 5 100 3.242e-05 0.0009142
166 POSITIVE REGULATION OF MITOTIC NUCLEAR DIVISION 4 51 3.585e-05 0.0009988
167 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 9 448 3.575e-05 0.0009988
168 RESPONSE TO WOUNDING 10 563 3.642e-05 0.001008
169 ORGAN MATURATION 3 18 3.66e-05 0.001008
170 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 3.723e-05 0.001013
171 REGULATION OF NEURON DEATH 7 252 3.723e-05 0.001013
172 NEGATIVE REGULATION OF NEURON DEATH 6 171 3.792e-05 0.001026
173 REGULATION OF GLUCOSE METABOLIC PROCESS 5 106 4.29e-05 0.001154
174 RESPONSE TO CORTICOSTEROID 6 176 4.455e-05 0.001191
175 REGULATION OF CELL DEVELOPMENT 12 836 4.619e-05 0.001228
176 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 9 465 4.772e-05 0.001262
177 BRANCHING INVOLVED IN MAMMARY GLAND DUCT MORPHOGENESIS 3 20 5.086e-05 0.001337
178 WOUND HEALING 9 470 5.183e-05 0.001354
179 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 6 181 5.208e-05 0.001354
180 SEX DIFFERENTIATION 7 266 5.244e-05 0.001356
181 NEGATIVE REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 21 5.919e-05 0.001521
182 RESPONSE TO NITROGEN COMPOUND 12 859 5.999e-05 0.001534
183 REGULATION OF CELL DIVISION 7 272 6.036e-05 0.001535
184 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 1152 6.195e-05 0.001566
185 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 7 274 6.32e-05 0.00159
186 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 6.557e-05 0.00164
187 STEM CELL PROLIFERATION 4 60 6.824e-05 0.001689
188 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 60 6.824e-05 0.001689
189 DEVELOPMENTAL MATURATION 6 193 7.435e-05 0.00183
190 POSITIVE REGULATION OF NUCLEAR DIVISION 4 62 7.763e-05 0.001891
191 REGULATION OF BINDING 7 283 7.74e-05 0.001891
192 DEPHOSPHORYLATION 7 286 8.268e-05 0.002004
193 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 6 197 8.326e-05 0.002007
194 REGULATION OF PROTEIN CATABOLIC PROCESS 8 393 9.128e-05 0.002189
195 POSITIVE REGULATION OF BINDING 5 127 0.0001014 0.00242
196 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 0.0001053 0.002499
197 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 8 404 0.0001105 0.002609
198 ORGAN GROWTH 4 68 0.0001115 0.00262
199 INACTIVATION OF MAPK ACTIVITY 3 26 0.0001142 0.00267
200 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 0.0001159 0.002696
201 NEGATIVE REGULATION OF CELL DEVELOPMENT 7 303 0.0001184 0.002741
202 POSITIVE REGULATION OF CELL DIVISION 5 132 0.0001217 0.002803
203 GROWTH 8 410 0.0001223 0.002803
204 REGULATION OF WNT SIGNALING PATHWAY 7 310 0.0001364 0.003111
205 REGULATION OF IMMUNE SYSTEM PROCESS 15 1403 0.0001381 0.00312
206 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 6 216 0.0001379 0.00312
207 RESPONSE TO ETHANOL 5 136 0.00014 0.003147
208 MAMMARY GLAND DUCT MORPHOGENESIS 3 28 0.0001431 0.003202
209 POSITIVE REGULATION OF LOCOMOTION 8 420 0.0001443 0.003212
210 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 6 218 0.000145 0.003214
211 EMBRYONIC HINDLIMB MORPHOGENESIS 3 29 0.0001592 0.003495
212 REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 29 0.0001592 0.003495
213 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 75 0.0001632 0.003565
214 REGULATION OF CELL CYCLE PHASE TRANSITION 7 321 0.0001691 0.003676
215 GLIAL CELL DEVELOPMENT 4 76 0.0001718 0.003718
216 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 3 30 0.0001765 0.003784
217 CELLULAR RESPONSE TO ESTRADIOL STIMULUS 3 30 0.0001765 0.003784
218 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 9 554 0.0001805 0.003821
219 REGULATION OF NEURON DIFFERENTIATION 9 554 0.0001805 0.003821
220 CELL FATE COMMITMENT 6 227 0.0001807 0.003821
221 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 0.0001951 0.004088
222 SCHWANN CELL DIFFERENTIATION 3 31 0.0001949 0.004088
223 REGULATION OF LEUKOCYTE DIFFERENTIATION 6 232 0.0002033 0.004242
224 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 148 0.0002078 0.004275
225 DIGESTIVE SYSTEM DEVELOPMENT 5 148 0.0002078 0.004275
226 POSITIVE REGULATION OF CELL GROWTH 5 148 0.0002078 0.004275
227 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 0.0002095 0.004275
228 CELLULAR RESPONSE TO MECHANICAL STIMULUS 4 80 0.0002095 0.004275
229 RESPONSE TO METAL ION 7 333 0.0002116 0.0043
230 REGULATION OF TRANSPORT 17 1804 0.0002128 0.004305
231 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0002144 0.00432
232 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 13 1142 0.0002249 0.00451
233 MUSCLE CELL DIFFERENTIATION 6 237 0.0002281 0.004554
234 EMBRYONIC AXIS SPECIFICATION 3 33 0.0002353 0.004619
235 REGULATION OF MYELINATION 3 33 0.0002353 0.004619
236 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 0.0002352 0.004619
237 POSITIVE REGULATION OF GROWTH 6 238 0.0002333 0.004619
238 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 153 0.0002425 0.004741
239 NEGATIVE REGULATION OF TRANSPORT 8 458 0.0002599 0.005059
240 POSITIVE REGULATION OF DNA REPLICATION 4 86 0.0002767 0.005364
241 NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 3 35 0.0002808 0.005398
242 NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS 3 35 0.0002808 0.005398
243 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 4 87 0.0002892 0.005538
244 WNT SIGNALING PATHWAY 7 351 0.0002914 0.005557
245 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 0.0003024 0.005743
246 POSITIVE REGULATION OF MAPK CASCADE 8 470 0.0003092 0.005848
247 SEGMENTATION 4 89 0.0003155 0.005895
248 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 4 89 0.0003155 0.005895
249 EPITHELIAL CELL PROLIFERATION 4 89 0.0003155 0.005895
250 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 11 876 0.0003169 0.005898
251 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 4 90 0.0003293 0.006104
252 HINDLIMB MORPHOGENESIS 3 37 0.0003316 0.006122
253 ENSHEATHMENT OF NEURONS 4 91 0.0003434 0.006292
254 AXON ENSHEATHMENT 4 91 0.0003434 0.006292
255 REGULATION OF HORMONE LEVELS 8 478 0.0003461 0.006316
256 RESPONSE TO INORGANIC SUBSTANCE 8 479 0.000351 0.006379
257 REGULATION OF APOPTOTIC SIGNALING PATHWAY 7 363 0.0003569 0.006461
258 RESPONSE TO TESTOSTERONE 3 38 0.0003591 0.006475
259 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 0.0003659 0.006573
260 REGULATION OF DNA BINDING 4 93 0.0003731 0.006678
261 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 750 0.0003802 0.006778
262 ERBB2 SIGNALING PATHWAY 3 39 0.000388 0.006824
263 ANATOMICAL STRUCTURE MATURATION 3 39 0.000388 0.006824
264 NEURAL TUBE FORMATION 4 94 0.0003887 0.006824
265 NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION 3 39 0.000388 0.006824
266 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 6 263 0.0003979 0.00696
267 CELLULAR RESPONSE TO EXTERNAL STIMULUS 6 264 0.000406 0.007075
268 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 0.0004157 0.007218
269 SENSORY ORGAN DEVELOPMENT 8 493 0.0004251 0.007353
270 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 0.0004269 0.007357
271 CELL SUBSTRATE JUNCTION ASSEMBLY 3 41 0.0004502 0.007729
272 RESPONSE TO VITAMIN 4 98 0.0004554 0.00779
273 MULTICELLULAR ORGANISM REPRODUCTION 10 768 0.000458 0.007807
274 POSITIVE REGULATION OF DNA BINDING 3 42 0.0004835 0.008211
275 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 4 100 0.0004916 0.008258
276 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 0.0004916 0.008258
277 LIMBIC SYSTEM DEVELOPMENT 4 100 0.0004916 0.008258
278 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 43 0.0005184 0.008677
279 RESPONSE TO KETONE 5 182 0.0005379 0.00897
280 REGULATION OF CELL GROWTH 7 391 0.0005561 0.009111
281 NEGATIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 3 44 0.0005549 0.009111
282 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 44 0.0005549 0.009111
283 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 4 103 0.0005497 0.009111
284 POSITIVE REGULATION OF TRANSPORT 11 936 0.000554 0.009111
285 BEHAVIOR 8 516 0.0005742 0.009374
286 POSITIVE REGULATION OF DNA METABOLIC PROCESS 5 185 0.0005793 0.009425
287 RESPONSE TO XENOBIOTIC STIMULUS 4 105 0.0005911 0.009515
288 MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY 3 45 0.000593 0.009515
289 SYSTEM PROCESS 16 1785 0.0005922 0.009515
290 HETEROPHILIC CELL CELL ADHESION VIA PLASMA MEMBRANE CELL ADHESION MOLECULES 3 45 0.000593 0.009515
NumGOOverlapSizeP ValueAdj. P Value
1 GLUCURONOSYLTRANSFERASE ACTIVITY 5 34 1.444e-07 0.0001342
2 GROWTH FACTOR BINDING 7 123 3.261e-07 0.0001515
3 IDENTICAL PROTEIN BINDING 17 1209 1.205e-06 0.0003732
4 INSULIN LIKE GROWTH FACTOR BINDING 4 25 1.949e-06 0.0004528
5 MONOCARBOXYLIC ACID BINDING 5 65 3.927e-06 0.0007296
6 PROTEIN TYROSINE SERINE THREONINE PHOSPHATASE ACTIVITY 4 45 2.173e-05 0.002523
7 MAP KINASE PHOSPHATASE ACTIVITY 3 14 1.65e-05 0.002523
8 INSULIN LIKE GROWTH FACTOR RECEPTOR BINDING 3 15 2.057e-05 0.002523
9 LIPID BINDING 11 657 2.47e-05 0.00255
10 PROTEIN TYROSINE PHOSPHATASE ACTIVITY 5 103 3.738e-05 0.003472
11 RETINOIC ACID BINDING 3 23 7.84e-05 0.006621
12 HORMONE BINDING 4 65 9.345e-05 0.007234
13 TRANSCRIPTION FACTOR BINDING 9 524 0.0001189 0.008494
14 ENZYME BINDING 17 1737 0.0001348 0.008943
15 UDP GLYCOSYLTRANSFERASE ACTIVITY 5 139 0.0001551 0.009604
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00983_Drug_metabolism_._other_enzymes 7 52 7.543e-10 1.358e-07
2 hsa00053_Ascorbate_and_aldarate_metabolism 5 26 3.493e-08 3.143e-06
3 hsa00040_Pentose_and_glucuronate_interconversions 5 32 1.051e-07 6.307e-06
4 hsa00860_Porphyrin_and_chlorophyll_metabolism 5 43 4.87e-07 1.768e-05
5 hsa04151_PI3K_AKT_signaling_pathway 10 351 5.682e-07 1.768e-05
6 hsa04510_Focal_adhesion 8 200 6.699e-07 1.768e-05
7 hsa00514_Other_types_of_O.glycan_biosynthesis 5 46 6.877e-07 1.768e-05
8 hsa00500_Starch_and_sucrose_metabolism 5 54 1.551e-06 3.49e-05
9 hsa00140_Steroid_hormone_biosynthesis 5 57 2.036e-06 4.072e-05
10 hsa00830_Retinol_metabolism 5 64 3.635e-06 6.543e-05
11 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 5 71 6.085e-06 9.958e-05
12 hsa00982_Drug_metabolism_._cytochrome_P450 5 73 6.981e-06 0.0001047
13 hsa04115_p53_signaling_pathway 4 69 0.000118 0.001634
14 hsa04014_Ras_signaling_pathway 6 236 0.0002229 0.002866
15 hsa04010_MAPK_signaling_pathway 6 268 0.0004396 0.005275
16 hsa04114_Oocyte_meiosis 4 114 0.0008051 0.009057
17 hsa04150_mTOR_signaling_pathway 3 52 0.0009068 0.009602
18 hsa04520_Adherens_junction 3 73 0.002416 0.02416
19 hsa04710_Circadian_rhythm_._mammal 2 23 0.003164 0.02997
20 hsa04012_ErbB_signaling_pathway 3 87 0.00397 0.03403
21 hsa04914_Progesterone.mediated_oocyte_maturation 3 87 0.00397 0.03403
22 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.0103 0.08424
23 hsa04910_Insulin_signaling_pathway 3 138 0.01407 0.1076
24 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.01434 0.1076
25 hsa04340_Hedgehog_signaling_pathway 2 56 0.01782 0.1236
26 hsa04310_Wnt_signaling_pathway 3 151 0.01786 0.1236
27 hsa04390_Hippo_signaling_pathway 3 154 0.0188 0.1254
28 hsa00230_Purine_metabolism 3 162 0.02146 0.138
29 hsa04141_Protein_processing_in_endoplasmic_reticulum 3 168 0.02359 0.1464
30 hsa04730_Long.term_depression 2 70 0.02705 0.1623
31 hsa04370_VEGF_signaling_pathway 2 76 0.03148 0.1828
32 hsa04350_TGF.beta_signaling_pathway 2 85 0.03862 0.2172
33 hsa04210_Apoptosis 2 89 0.04197 0.2289
34 hsa04722_Neurotrophin_signaling_pathway 2 127 0.07857 0.3982
35 hsa04110_Cell_cycle 2 128 0.07963 0.3982
36 hsa04530_Tight_junction 2 133 0.08502 0.4136
37 hsa04630_Jak.STAT_signaling_pathway 2 155 0.11 0.5208
38 hsa04020_Calcium_signaling_pathway 2 177 0.1365 0.6301
39 hsa04144_Endocytosis 2 203 0.1695 0.7442

Quest ID: 8194a6e488ef98708a86641544abe136