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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-338-5p CD9 -0.58 0.04722 -0.05 0.81687 PITA; miRNATAP -0.12 0.00157 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 BIOLOGICAL ADHESION 42 1032 2.174e-32 1.012e-28
2 IMMUNE SYSTEM PROCESS 46 1984 2.742e-25 6.379e-22
3 LOCOMOTION 36 1114 8.014e-24 1.243e-20
4 CELL ACTIVATION 27 568 7.56e-22 8.794e-19
5 REGULATION OF CELL PROLIFERATION 37 1496 1.486e-20 1.383e-17
6 REGULATION OF IMMUNE SYSTEM PROCESS 36 1403 1.831e-20 1.42e-17
7 SINGLE ORGANISM CELL ADHESION 24 459 2.398e-20 1.594e-17
8 CELL MOTILITY 29 835 9.502e-20 4.512e-17
9 LOCALIZATION OF CELL 29 835 9.502e-20 4.512e-17
10 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 34 1275 9.696e-20 4.512e-17
11 LEUKOCYTE MIGRATION 19 259 6.661e-19 2.818e-16
12 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 28 867 3.245e-18 1.258e-15
13 LYMPHOCYTE ACTIVATION 20 342 6.229e-18 2.23e-15
14 CELL CELL ADHESION 24 608 1.554e-17 5.163e-15
15 POSITIVE REGULATION OF CELL ACTIVATION 19 311 2.065e-17 6.406e-15
16 REGULATION OF CELL ACTIVATION 22 484 2.3e-17 6.688e-15
17 POSITIVE REGULATION OF RESPONSE TO STIMULUS 37 1929 7.116e-17 1.948e-14
18 LEUKOCYTE ACTIVATION 20 414 2.532e-16 6.545e-14
19 LEUKOCYTE CELL CELL ADHESION 17 255 2.819e-16 6.902e-14
20 REGULATION OF IMMUNE RESPONSE 26 858 3.229e-16 7.512e-14
21 REGULATION OF CELL ADHESION 23 629 4.372e-16 9.687e-14
22 POSITIVE REGULATION OF CELL ADHESION 19 376 6.889e-16 1.457e-13
23 REGULATION OF CELL CELL ADHESION 19 380 8.362e-16 1.692e-13
24 BLOOD VESSEL MORPHOGENESIS 18 364 6.406e-15 1.242e-12
25 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 30 1395 9.591e-15 1.785e-12
26 POSITIVE REGULATION OF CELL PROLIFERATION 24 814 1.062e-14 1.901e-12
27 POSITIVE REGULATION OF CELL CELL ADHESION 15 243 5.822e-14 1.003e-11
28 REGULATION OF HOMOTYPIC CELL CELL ADHESION 16 307 1.078e-13 1.792e-11
29 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 31 1672 1.633e-13 2.62e-11
30 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 26 1142 2.697e-13 4.184e-11
31 REGULATION OF CELL DEATH 29 1472 2.901e-13 4.355e-11
32 REGULATION OF CELLULAR COMPONENT MOVEMENT 22 771 3.322e-13 4.831e-11
33 VASCULATURE DEVELOPMENT 18 469 4.889e-13 6.894e-11
34 ANGIOGENESIS 15 293 8.877e-13 1.215e-10
35 INTEGRIN MEDIATED SIGNALING PATHWAY 10 82 1.283e-12 1.706e-10
36 DEFENSE RESPONSE 26 1231 1.504e-12 1.899e-10
37 EXTRACELLULAR STRUCTURE ORGANIZATION 15 304 1.51e-12 1.899e-10
38 IMMUNE RESPONSE 24 1100 6.958e-12 8.52e-10
39 RESPONSE TO WOUNDING 18 563 1.035e-11 1.235e-09
40 POSITIVE REGULATION OF LOCOMOTION 16 420 1.267e-11 1.474e-09
41 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 22 957 2.351e-11 2.668e-09
42 LYMPHOCYTE COSTIMULATION 9 78 3.023e-11 3.349e-09
43 WOUND HEALING 16 470 6.749e-11 7.303e-09
44 POSITIVE REGULATION OF IMMUNE RESPONSE 17 563 1.025e-10 1.084e-08
45 ACTIVATION OF IMMUNE RESPONSE 15 427 1.847e-10 1.91e-08
46 CELL DEVELOPMENT 25 1426 2.487e-10 2.515e-08
47 PEPTIDYL TYROSINE MODIFICATION 11 186 2.639e-10 2.613e-08
48 CARDIOVASCULAR SYSTEM DEVELOPMENT 19 788 3.166e-10 3.006e-08
49 CIRCULATORY SYSTEM DEVELOPMENT 19 788 3.166e-10 3.006e-08
50 TAXIS 15 464 5.825e-10 5.421e-08
51 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 21 1036 7.343e-10 6.571e-08
52 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1036 7.343e-10 6.571e-08
53 POSITIVE REGULATION OF CELL COMMUNICATION 25 1532 1.111e-09 9.569e-08
54 IMMUNE EFFECTOR PROCESS 15 486 1.099e-09 9.569e-08
55 CELL CHEMOTAXIS 10 162 1.192e-09 9.982e-08
56 INTERSPECIES INTERACTION BETWEEN ORGANISMS 17 662 1.223e-09 9.982e-08
57 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 17 662 1.223e-09 9.982e-08
58 CELL SUBSTRATE ADHESION 10 164 1.343e-09 1.078e-07
59 NEGATIVE REGULATION OF CELL DEATH 19 872 1.708e-09 1.347e-07
60 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 2.532e-09 1.785e-07
61 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 2.532e-09 1.785e-07
62 VIRAL ENTRY INTO HOST CELL 8 87 2.532e-09 1.785e-07
63 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 2.532e-09 1.785e-07
64 MOVEMENT IN HOST ENVIRONMENT 8 87 2.532e-09 1.785e-07
65 ENTRY INTO HOST 8 87 2.532e-09 1.785e-07
66 ENTRY INTO HOST CELL 8 87 2.532e-09 1.785e-07
67 REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1618 3.413e-09 2.37e-07
68 REGULATION OF CELL DIFFERENTIATION 24 1492 3.516e-09 2.371e-07
69 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 24 1492 3.516e-09 2.371e-07
70 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 20 1021 3.651e-09 2.427e-07
71 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 19 926 4.576e-09 2.999e-07
72 POSITIVE REGULATION OF CELL DIFFERENTIATION 18 823 4.665e-09 3.015e-07
73 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 1656 5.474e-09 3.489e-07
74 PROTEIN AUTOPHOSPHORYLATION 10 192 6.177e-09 3.884e-07
75 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 12 323 7.742e-09 4.803e-07
76 REGULATION OF PROTEIN MODIFICATION PROCESS 25 1710 1.047e-08 6.409e-07
77 REGULATION OF NEURON PROJECTION DEVELOPMENT 13 408 1.093e-08 6.602e-07
78 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 876 1.229e-08 7.33e-07
79 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 14 498 1.371e-08 8.077e-07
80 LYMPHOCYTE DIFFERENTIATION 10 209 1.392e-08 8.094e-07
81 RECEPTOR CLUSTERING 6 41 1.581e-08 9.084e-07
82 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 16 689 1.664e-08 9.44e-07
83 ADAPTIVE IMMUNE RESPONSE 11 288 2.582e-08 1.447e-06
84 INNATE IMMUNE RESPONSE 15 619 2.833e-08 1.551e-06
85 HETEROPHILIC CELL CELL ADHESION VIA PLASMA MEMBRANE CELL ADHESION MOLECULES 6 45 2.827e-08 1.551e-06
86 REGULATION OF AXONOGENESIS 9 168 2.911e-08 1.575e-06
87 LEUKOCYTE DIFFERENTIATION 11 292 2.973e-08 1.59e-06
88 CELL MATRIX ADHESION 8 119 3.058e-08 1.617e-06
89 INOSITOL LIPID MEDIATED SIGNALING 8 124 4.222e-08 2.207e-06
90 REGULATION OF CELL PROJECTION ORGANIZATION 14 558 5.666e-08 2.929e-06
91 REGULATION OF ANATOMICAL STRUCTURE SIZE 13 472 6.057e-08 3.097e-06
92 INTERACTION WITH HOST 8 134 7.732e-08 3.869e-06
93 HETEROTYPIC CELL CELL ADHESION 5 27 7.7e-08 3.869e-06
94 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 8 135 8.192e-08 4.012e-06
95 REGULATION OF NEURON DEATH 10 252 8.147e-08 4.012e-06
96 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 8 136 8.676e-08 4.205e-06
97 REGULATION OF NEURON APOPTOTIC PROCESS 9 192 9.197e-08 4.411e-06
98 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 9 193 9.615e-08 4.565e-06
99 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 138 9.716e-08 4.567e-06
100 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 9 195 1.05e-07 4.886e-06
101 REGULATION OF DEFENSE RESPONSE TO VIRUS BY VIRUS 5 29 1.126e-07 5.185e-06
102 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 19 1135 1.179e-07 5.378e-06
103 PLATELET ACTIVATION 8 142 1.212e-07 5.424e-06
104 TISSUE DEVELOPMENT 22 1518 1.203e-07 5.424e-06
105 REGULATION OF IMMUNE EFFECTOR PROCESS 12 424 1.531e-07 6.786e-06
106 LIPID PHOSPHORYLATION 7 99 1.649e-07 7.237e-06
107 REGULATION OF LEUKOCYTE PROLIFERATION 9 206 1.676e-07 7.29e-06
108 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 8 156 2.502e-07 1.078e-05
109 INFLAMMATORY RESPONSE 12 454 3.186e-07 1.36e-05
110 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 15 750 3.41e-07 1.443e-05
111 REGULATION OF CELL MORPHOGENESIS 13 552 3.661e-07 1.535e-05
112 REGULATION OF NEURON DIFFERENTIATION 13 554 3.815e-07 1.585e-05
113 REGULATION OF MAPK CASCADE 14 660 4.381e-07 1.804e-05
114 NEGATIVE REGULATION OF NEURON DEATH 8 171 5.044e-07 2.059e-05
115 REGULATION OF CELL SIZE 8 172 5.273e-07 2.102e-05
116 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 5 39 5.284e-07 2.102e-05
117 CELLULAR CHEMICAL HOMEOSTASIS 13 570 5.264e-07 2.102e-05
118 POSITIVE REGULATION OF GROWTH 9 238 5.667e-07 2.235e-05
119 POSITIVE REGULATION OF CHEMOTAXIS 7 120 6.149e-07 2.404e-05
120 CELLULAR COMPONENT MORPHOGENESIS 16 900 6.342e-07 2.459e-05
121 IMMUNE SYSTEM DEVELOPMENT 13 582 6.655e-07 2.559e-05
122 RESPONSE TO EXTERNAL STIMULUS 23 1821 6.754e-07 2.576e-05
123 LOCALIZATION WITHIN MEMBRANE 7 122 6.879e-07 2.602e-05
124 REGULATION OF ADAPTIVE IMMUNE RESPONSE 7 123 7.27e-07 2.728e-05
125 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 18 1152 7.424e-07 2.749e-05
126 REGULATION OF CHEMOTAXIS 8 180 7.443e-07 2.749e-05
127 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 23 1848 8.74e-07 3.202e-05
128 CELL JUNCTION ORGANIZATION 8 185 9.155e-07 3.328e-05
129 LEUKOCYTE MEDIATED IMMUNITY 8 189 1.076e-06 3.88e-05
130 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 513 1.157e-06 4.142e-05
131 NEGATIVE REGULATION OF LOCOMOTION 9 263 1.301e-06 4.622e-05
132 DIVALENT INORGANIC CATION HOMEOSTASIS 10 343 1.383e-06 4.874e-05
133 GLYCEROLIPID METABOLIC PROCESS 10 356 1.931e-06 6.756e-05
134 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 983 2.015e-06 6.957e-05
135 NEGATIVE REGULATION OF CELL PROLIFERATION 13 643 2.018e-06 6.957e-05
136 VESICLE MEDIATED TRANSPORT 18 1239 2.108e-06 7.212e-05
137 REGULATION OF TRANSPORT 22 1804 2.277e-06 7.732e-05
138 T CELL RECEPTOR SIGNALING PATHWAY 7 146 2.301e-06 7.759e-05
139 REGULATION OF T CELL PROLIFERATION 7 147 2.408e-06 8.062e-05
140 CELL RECOGNITION 7 148 2.52e-06 8.374e-05
141 POSITIVE REGULATION OF T CELL PROLIFERATION 6 95 2.563e-06 8.459e-05
142 POSITIVE REGULATION OF CALCIUM ION IMPORT 5 54 2.766e-06 9.064e-05
143 REGULATION OF DEVELOPMENTAL GROWTH 9 289 2.825e-06 9.192e-05
144 VIRAL LIFE CYCLE 9 290 2.906e-06 9.325e-05
145 NEUROGENESIS 19 1402 2.898e-06 9.325e-05
146 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 6 98 3.075e-06 9.799e-05
147 CELLULAR EXTRAVASATION 4 25 3.109e-06 9.841e-05
148 POSITIVE REGULATION OF MAPK CASCADE 11 470 3.347e-06 0.0001052
149 CELLULAR HOMEOSTASIS 13 676 3.494e-06 0.0001091
150 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 9 297 3.53e-06 0.0001095
151 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 7 156 3.574e-06 0.0001101
152 REGULATION OF EXTENT OF CELL GROWTH 6 101 3.666e-06 0.0001122
153 ION HOMEOSTASIS 12 576 3.833e-06 0.0001158
154 REGULATED EXOCYTOSIS 8 224 3.821e-06 0.0001158
155 INTRACELLULAR SIGNAL TRANSDUCTION 20 1572 3.927e-06 0.0001179
156 NEURON DEVELOPMENT 13 687 4.166e-06 0.0001242
157 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 8 232 4.95e-06 0.0001467
158 HEMOSTASIS 9 311 5.131e-06 0.0001511
159 MORPHOGENESIS OF AN EPITHELIUM 10 400 5.433e-06 0.000159
160 REGULATION OF HEMOPOIESIS 9 314 5.545e-06 0.0001602
161 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 62 5.517e-06 0.0001602
162 MORPHOGENESIS OF A BRANCHING STRUCTURE 7 167 5.606e-06 0.000161
163 REGULATION OF RESPONSE TO STRESS 19 1468 5.666e-06 0.0001617
164 REGULATION OF ERK1 AND ERK2 CASCADE 8 238 5.971e-06 0.0001694
165 HOMEOSTATIC PROCESS 18 1337 6.127e-06 0.0001728
166 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 4 30 6.631e-06 0.0001859
167 REGULATION OF BODY FLUID LEVELS 11 506 6.752e-06 0.0001881
168 REGULATION OF CELL DEVELOPMENT 14 836 6.967e-06 0.000193
169 ENDOCYTOSIS 11 509 7.139e-06 0.0001966
170 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 6 114 7.394e-06 0.0002024
171 POSITIVE REGULATION OF MOLECULAR FUNCTION 21 1791 7.625e-06 0.0002075
172 POSITIVE REGULATION OF AXONOGENESIS 5 69 9.369e-06 0.0002535
173 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 337 9.787e-06 0.0002617
174 REGULATION OF CELLULAR COMPONENT SIZE 9 337 9.787e-06 0.0002617
175 TISSUE MORPHOGENESIS 11 533 1.1e-05 0.0002926
176 CENTRAL NERVOUS SYSTEM DEVELOPMENT 14 872 1.123e-05 0.0002969
177 EPITHELIAL CELL DEVELOPMENT 7 186 1.135e-05 0.0002983
178 CHEMICAL HOMEOSTASIS 14 874 1.152e-05 0.0003012
179 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 437 1.176e-05 0.0003057
180 CELL DEATH 15 1001 1.191e-05 0.0003079
181 NEURON PROJECTION DEVELOPMENT 11 545 1.354e-05 0.0003482
182 POSITIVE REGULATION OF AXON EXTENSION 4 36 1.399e-05 0.0003577
183 CELL JUNCTION ASSEMBLY 6 129 1.502e-05 0.0003819
184 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 6 131 1.64e-05 0.0004146
185 PHOSPHOLIPID METABOLIC PROCESS 9 364 1.806e-05 0.0004542
186 NEGATIVE T CELL SELECTION 3 13 1.844e-05 0.0004614
187 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 7 203 1.999e-05 0.0004973
188 ENDODERMAL CELL DIFFERENTIATION 4 40 2.144e-05 0.0005305
189 REGULATION OF MULTI ORGANISM PROCESS 10 470 2.2e-05 0.0005417
190 REGULATION OF B CELL MEDIATED IMMUNITY 4 41 2.368e-05 0.0005769
191 CELL SUBSTRATE JUNCTION ASSEMBLY 4 41 2.368e-05 0.0005769
192 LIPID MODIFICATION 7 210 2.485e-05 0.0005991
193 POSITIVE REGULATION OF TRANSPORT 14 936 2.474e-05 0.0005991
194 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 2.728e-05 0.0006461
195 EPITHELIUM DEVELOPMENT 14 945 2.749e-05 0.0006461
196 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 7 213 2.721e-05 0.0006461
197 PROTEIN PHOSPHORYLATION 14 944 2.717e-05 0.0006461
198 POSITIVE REGULATION OF B CELL ACTIVATION 5 86 2.749e-05 0.0006461
199 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 2.89e-05 0.0006758
200 SYNAPSE ORGANIZATION 6 145 2.914e-05 0.0006779
201 UROGENITAL SYSTEM DEVELOPMENT 8 299 3.105e-05 0.0007189
202 LYMPHOCYTE MEDIATED IMMUNITY 6 147 3.148e-05 0.000725
203 POSITIVE REGULATION OF CELL GROWTH 6 148 3.27e-05 0.0007473
204 RESPONSE TO CYTOKINE 12 714 3.278e-05 0.0007473
205 PHOSPHORYLATION 16 1228 3.292e-05 0.0007473
206 CALCIUM MEDIATED SIGNALING 5 90 3.426e-05 0.0007663
207 POSITIVE REGULATION OF CATALYTIC ACTIVITY 18 1518 3.42e-05 0.0007663
208 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 8 303 3.413e-05 0.0007663
209 PEPTIDYL AMINO ACID MODIFICATION 13 841 3.561e-05 0.000789
210 ORGAN MORPHOGENESIS 13 841 3.561e-05 0.000789
211 POSITIVE REGULATION OF NEURON DIFFERENTIATION 8 306 3.66e-05 0.0008071
212 RESPONSE TO OXYGEN CONTAINING COMPOUND 17 1381 3.688e-05 0.0008095
213 NEURON PROJECTION MORPHOGENESIS 9 402 3.931e-05 0.0008586
214 EXOCYTOSIS 8 310 4.012e-05 0.0008724
215 AMEBOIDAL TYPE CELL MIGRATION 6 154 4.087e-05 0.0008842
216 RESPONSE TO OXYGEN LEVELS 8 311 4.105e-05 0.0008842
217 REGULATION OF LEUKOCYTE DIFFERENTIATION 7 232 4.689e-05 0.001005
218 REGULATION OF RESPONSE TO WOUNDING 9 413 4.844e-05 0.001029
219 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 4 49 4.832e-05 0.001029
220 REGULATION OF MAP KINASE ACTIVITY 8 319 4.91e-05 0.001038
221 SECOND MESSENGER MEDIATED SIGNALING 6 160 5.06e-05 0.001065
222 RESPONSE TO PLATELET DERIVED GROWTH FACTOR 3 18 5.185e-05 0.001087
223 ENDODERM FORMATION 4 50 5.236e-05 0.001093
224 NEURON DIFFERENTIATION 13 874 5.289e-05 0.001099
225 REGULATION OF RESPONSE TO BIOTIC STIMULUS 7 237 5.366e-05 0.001105
226 TUBE MORPHOGENESIS 8 323 5.359e-05 0.001105
227 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 6 162 5.422e-05 0.001111
228 ARTERY MORPHOGENESIS 4 51 5.664e-05 0.001156
229 REGULATION OF DEFENSE RESPONSE 12 759 5.918e-05 0.001202
230 THYMIC T CELL SELECTION 3 19 6.139e-05 0.001237
231 POSITIVE REGULATION OF ALPHA BETA T CELL PROLIFERATION 3 19 6.139e-05 0.001237
232 REGULATION OF CALCIUM ION IMPORT 5 103 6.545e-05 0.001313
233 B CELL RECEPTOR SIGNALING PATHWAY 4 54 7.101e-05 0.001418
234 REGULATION OF KINASE ACTIVITY 12 776 7.314e-05 0.001448
235 CELL PROJECTION ORGANIZATION 13 902 7.289e-05 0.001448
236 POSITIVE REGULATION OF CALCIUM ION TRANSPORT 5 106 7.505e-05 0.001478
237 POSITIVE REGULATION OF HYDROLASE ACTIVITY 13 905 7.538e-05 0.001478
238 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 6 172 7.561e-05 0.001478
239 REGULATION OF SEQUESTERING OF CALCIUM ION 5 107 7.848e-05 0.001521
240 PLATELET DEGRANULATION 5 107 7.848e-05 0.001521
241 GLIOGENESIS 6 175 8.319e-05 0.001606
242 TUBE DEVELOPMENT 10 552 8.502e-05 0.001635
243 SYSTEM PROCESS 19 1785 8.637e-05 0.001654
244 ENDOTHELIAL CELL MIGRATION 4 57 8.787e-05 0.001676
245 REGULATION OF HOMEOSTATIC PROCESS 9 447 8.884e-05 0.001687
246 NEURON MIGRATION 5 110 8.948e-05 0.001693
247 CELL PROLIFERATION 11 672 9.097e-05 0.001714
248 NEPHRON DEVELOPMENT 5 115 0.0001104 0.002072
249 REGULATION OF ALPHA BETA T CELL PROLIFERATION 3 23 0.0001109 0.002072
250 FOREBRAIN CELL MIGRATION 4 62 0.0001222 0.002274
251 CIRCULATORY SYSTEM PROCESS 8 366 0.0001277 0.002368
252 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 470 0.0001299 0.002398
253 REGULATION OF DEFENSE RESPONSE TO VIRUS 6 190 0.0001307 0.002403
254 POSITIVE REGULATION OF CELL DEVELOPMENT 9 472 0.0001341 0.002456
255 REGULATION OF B CELL ACTIVATION 5 121 0.0001403 0.002561
256 REGULATION OF ION TRANSPORT 10 592 0.0001508 0.002741
257 T CELL DIFFERENTIATION 5 123 0.0001516 0.002744
258 NEGATIVE REGULATION OF HOMEOSTATIC PROCESS 5 124 0.0001574 0.002839
259 KIDNEY EPITHELIUM DEVELOPMENT 5 125 0.0001635 0.002936
260 REGULATION OF WOUND HEALING 5 126 0.0001697 0.003036
261 REGULATION OF ION HOMEOSTASIS 6 201 0.0001775 0.003165
262 POSITIVE REGULATION OF HEART GROWTH 3 27 0.000181 0.003214
263 CELLULAR RESPONSE TO CYTOKINE STIMULUS 10 606 0.0001822 0.003223
264 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 0.0001844 0.00325
265 SENSORY ORGAN DEVELOPMENT 9 493 0.0001857 0.003261
266 EPITHELIAL CELL DIFFERENTIATION 9 495 0.0001914 0.003348
267 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 6 204 0.0001924 0.003352
268 NEURON PROJECTION GUIDANCE 6 205 0.0001975 0.003429
269 REGULATION OF CELL GROWTH 8 391 0.0002006 0.003469
270 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 5 131 0.0002035 0.003481
271 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 131 0.0002035 0.003481
272 POSITIVE REGULATION OF PHOSPHATASE ACTIVITY 3 28 0.0002021 0.003481
273 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 0.0002079 0.003522
274 ENDODERM DEVELOPMENT 4 71 0.0002069 0.003522
275 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 0.0002082 0.003522
276 B CELL ACTIVATION 5 132 0.0002108 0.003541
277 REGULATION OF LYMPHOCYTE DIFFERENTIATION 5 132 0.0002108 0.003541
278 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 5 133 0.0002183 0.003655
279 REGULATION OF CALCIUM ION TRANSPORT 6 209 0.0002193 0.003657
280 GLIAL CELL DIFFERENTIATION 5 136 0.0002422 0.004025
281 ARTERY DEVELOPMENT 4 75 0.0002557 0.004234
282 CELL PART MORPHOGENESIS 10 633 0.0002585 0.00425
283 REGULATION OF GROWTH 10 633 0.0002585 0.00425
284 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 139 0.000268 0.004375
285 REGULATION OF CELL SHAPE 5 139 0.000268 0.004375
286 GLIAL CELL DEVELOPMENT 4 76 0.000269 0.004377
287 REGULATION OF PLATELET ACTIVATION 3 31 0.0002748 0.004456
288 PATTERNING OF BLOOD VESSELS 3 32 0.0003024 0.004868
289 NEGATIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 32 0.0003024 0.004868
290 CALCIUM ION TRANSPORT 6 223 0.0003106 0.004983
291 DENDRITE DEVELOPMENT 4 79 0.0003122 0.004991
292 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 144 0.0003155 0.005027
293 TELENCEPHALON DEVELOPMENT 6 228 0.0003496 0.005552
294 REGULATION OF TRANSMEMBRANE TRANSPORT 8 426 0.000357 0.00565
295 KIDNEY MORPHOGENESIS 4 82 0.00036 0.005679
296 REGULATION OF CYTOKINE SECRETION 5 149 0.0003692 0.005803
297 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 6 232 0.0003835 0.005988
298 EYE DEVELOPMENT 7 326 0.0003828 0.005988
299 REGULATION OF VASCULATURE DEVELOPMENT 6 233 0.0003924 0.006106
300 TISSUE MIGRATION 4 84 0.0003947 0.006122
301 POSITIVE REGULATION OF ION TRANSPORT 6 236 0.0004199 0.006491
302 ADAPTIVE IMMUNE RESPONSE BASED ON SOMATIC RECOMBINATION OF IMMUNE RECEPTORS BUILT FROM IMMUNOGLOBULIN SUPERFAMILY DOMAINS 5 154 0.0004295 0.006563
303 NEGATIVE REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 3 36 0.0004302 0.006563
304 T CELL SELECTION 3 36 0.0004302 0.006563
305 POSITIVE CHEMOTAXIS 3 36 0.0004302 0.006563
306 REGULATION OF TRANSFERASE ACTIVITY 12 946 0.0004566 0.006944
307 NEGATIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 3 37 0.0004668 0.007074
308 REGULATION OF COAGULATION 4 88 0.0004711 0.007118
309 REGULATION OF CYTOKINE PRODUCTION 9 563 0.0004913 0.007398
310 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 38 0.0005053 0.007559
311 POSITIVE REGULATION OF ORGAN GROWTH 3 38 0.0005053 0.007559
312 MESONEPHROS DEVELOPMENT 4 90 0.0005131 0.007652
313 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 6 246 0.0005228 0.007772
314 CYTOKINE MEDIATED SIGNALING PATHWAY 8 452 0.0005284 0.007831
315 ENSHEATHMENT OF NEURONS 4 91 0.000535 0.007878
316 AXON ENSHEATHMENT 4 91 0.000535 0.007878
317 REGULATION OF PHOSPHOLIPASE C ACTIVITY 3 39 0.0005458 0.007911
318 POSITIVE REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 3 39 0.0005458 0.007911
319 REGULATION OF CELL ADHESION MEDIATED BY INTEGRIN 3 39 0.0005458 0.007911
320 PLATELET AGGREGATION 3 39 0.0005458 0.007911
321 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 0.0005411 0.007911
322 POSITIVE REGULATION OF HEMOPOIESIS 5 163 0.0005564 0.008016
323 VASCULAR PROCESS IN CIRCULATORY SYSTEM 5 163 0.0005564 0.008016
324 REGULATION OF SECRETION 10 699 0.0005641 0.008101
325 NEPHRON EPITHELIUM DEVELOPMENT 4 93 0.0005808 0.008316
326 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 5 166 0.0006044 0.008627
327 HEAD DEVELOPMENT 10 709 0.0006297 0.00896
328 MYELOID CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 3 41 0.0006328 0.008977
329 REGULATION OF CELLULAR LOCALIZATION 14 1277 0.0006421 0.009081
330 REGULATION OF INNATE IMMUNE RESPONSE 7 357 0.000657 0.009208
331 FOREBRAIN DEVELOPMENT 7 357 0.000657 0.009208
332 POSITIVE REGULATION OF CYTOKINE SECRETION 4 96 0.0006547 0.009208
333 SECRETION 9 588 0.0006707 0.009372
334 CALCIUM ION TRANSMEMBRANE IMPORT INTO CYTOSOL 3 42 0.0006795 0.009382
335 DENDRITE MORPHOGENESIS 3 42 0.0006795 0.009382
336 REGULATION OF HEART GROWTH 3 42 0.0006795 0.009382
337 CALCIUM ION IMPORT INTO CYTOSOL 3 42 0.0006795 0.009382
338 MYELOID LEUKOCYTE ACTIVATION 4 98 0.0007076 0.00974
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR ACTIVITY 34 1649 2.643e-16 2.455e-13
2 RECEPTOR BINDING 31 1476 5.559e-15 2.582e-12
3 CELL ADHESION MOLECULE BINDING 14 186 2.798e-14 8.664e-12
4 PROTEIN COMPLEX BINDING 22 935 1.496e-11 2.982e-09
5 INTEGRIN BINDING 10 105 1.605e-11 2.982e-09
6 PROTEIN TYROSINE KINASE ACTIVITY 11 176 1.459e-10 2.259e-08
7 VIRUS RECEPTOR ACTIVITY 8 70 4.326e-10 5.741e-08
8 MACROMOLECULAR COMPLEX BINDING 23 1399 5.421e-09 6.295e-07
9 CORECEPTOR ACTIVITY 6 38 9.805e-09 1.012e-06
10 SIGNAL TRANSDUCER ACTIVITY 25 1731 1.337e-08 1.233e-06
11 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 1.46e-08 1.233e-06
12 SIGNALING RECEPTOR ACTIVITY 22 1393 2.626e-08 2.033e-06
13 IDENTICAL PROTEIN BINDING 19 1209 3.132e-07 2.238e-05
14 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 6 81 1.002e-06 6.648e-05
15 NON MEMBRANE SPANNING PROTEIN TYROSINE KINASE ACTIVITY 5 46 1.23e-06 7.619e-05
16 KINASE ACTIVITY 15 842 1.46e-06 8.475e-05
17 PROTEIN KINASE ACTIVITY 13 640 1.917e-06 0.0001048
18 CYTOKINE BINDING 6 92 2.124e-06 0.0001096
19 GLYCOPROTEIN BINDING 6 101 3.666e-06 0.0001792
20 KINASE BINDING 12 606 6.425e-06 0.0002857
21 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 5 64 6.459e-06 0.0002857
22 PROTEIN HOMODIMERIZATION ACTIVITY 13 722 7.127e-06 0.000301
23 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 992 1.07e-05 0.0004322
24 CARBOHYDRATE BINDING 8 277 1.798e-05 0.000696
25 PROTEIN DIMERIZATION ACTIVITY 15 1149 5.901e-05 0.002193
26 ANTIGEN BINDING 5 114 0.000106 0.003786
27 GLYCOSAMINOGLYCAN BINDING 6 205 0.0001975 0.006553
28 ENZYME BINDING 18 1737 0.0001934 0.006553
29 PHOSPHATIDYLINOSITOL 3 KINASE BINDING 3 30 0.000249 0.007976
NumGOOverlapSizeP ValueAdj. P Value
1 CELL SURFACE 37 757 5.97e-31 3.487e-28
2 SIDE OF MEMBRANE 27 428 4.307e-25 1.258e-22
3 EXTERNAL SIDE OF PLASMA MEMBRANE 22 238 4.647e-24 9.047e-22
4 INTRINSIC COMPONENT OF PLASMA MEMBRANE 33 1649 2.091e-15 3.053e-13
5 MEMBRANE MICRODOMAIN 16 288 4.009e-14 4.683e-12
6 CELL SUBSTRATE JUNCTION 17 398 4.264e-13 4.15e-11
7 ANCHORING JUNCTION 18 489 9.88e-13 8.243e-11
8 MEMBRANE REGION 24 1134 1.318e-11 9.62e-10
9 CELL JUNCTION 24 1151 1.798e-11 1.167e-09
10 RECEPTOR COMPLEX 13 327 7.622e-10 4.451e-08
11 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 6 30 2.165e-09 1.149e-07
12 PLASMA MEMBRANE RECEPTOR COMPLEX 10 175 2.525e-09 1.229e-07
13 IMMUNOLOGICAL SYNAPSE 6 33 3.998e-09 1.796e-07
14 PLASMA MEMBRANE PROTEIN COMPLEX 14 510 1.849e-08 7.714e-07
15 CELL CELL JUNCTION 12 383 5.081e-08 1.978e-06
16 EXTRACELLULAR SPACE 20 1376 4.976e-07 1.816e-05
17 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 7 136 1.431e-06 4.917e-05
18 APICAL PART OF CELL 10 361 2.188e-06 7.098e-05
19 APICAL PLASMA MEMBRANE 9 292 3.074e-06 9.448e-05
20 PLASMA MEMBRANE REGION 15 929 4.871e-06 0.0001422
21 INTRACELLULAR VESICLE 17 1259 1.123e-05 0.0003124
22 CELL LEADING EDGE 9 350 1.323e-05 0.0003513
23 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 5 98 5.159e-05 0.00131
24 EXTRACELLULAR MATRIX 9 426 6.15e-05 0.001418
25 T CELL RECEPTOR COMPLEX 3 19 6.139e-05 0.001418
26 MEMBRANE PROTEIN COMPLEX 14 1020 6.311e-05 0.001418
27 CYTOPLASMIC SIDE OF MEMBRANE 6 170 7.087e-05 0.001533
28 EXTRINSIC COMPONENT OF MEMBRANE 7 252 7.892e-05 0.001646
29 CELL PROJECTION 18 1786 0.000273 0.005497
30 VACUOLE 14 1180 0.0002906 0.005658
31 PLASMA MEMBRANE RAFT 4 86 0.0004317 0.008133

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_adhesion_molecules_.CAMs._hsa04514 12 145 7.133e-13 3.709e-11
2 Regulation_of_actin_cytoskeleton_hsa04810 11 208 8.676e-10 2.256e-08
3 NF_kappa_B_signaling_pathway_hsa04064 7 95 1.24e-07 2.149e-06
4 Rap1_signaling_pathway_hsa04015 9 206 1.676e-07 2.179e-06
5 Focal_adhesion_hsa04510 8 199 1.584e-06 1.512e-05
6 PI3K_Akt_signaling_pathway_hsa04151 10 352 1.745e-06 1.512e-05
7 Ras_signaling_pathway_hsa04014 7 232 4.689e-05 0.0003483
8 ECM_receptor_interaction_hsa04512 4 82 0.00036 0.00234
9 Cytokine_cytokine_receptor_interaction_hsa04060 6 270 0.0008503 0.004913
10 MAPK_signaling_pathway_hsa04010 6 295 0.001341 0.006971
11 Calcium_signaling_pathway_hsa04020 4 182 0.006685 0.0316
12 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.02219 0.09616
13 Phagosome_hsa04145 3 152 0.02463 0.09852
14 Adherens_junction_hsa04520 2 72 0.03528 0.131
15 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.1113 0.3859
16 cAMP_signaling_pathway_hsa04024 2 198 0.195 0.6336

Quest ID: 82ad16dbc5cc01961ee9146833543aa2