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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-182-5p AASS 3.54 0 -1.35 5.0E-5 MirTarget -0.12 0.00483 NA
2 hsa-miR-182-5p AATK 3.54 0 -0.62 0.02571 MirTarget -0.11 0.00069 NA
3 hsa-miR-182-5p ABL2 3.54 0 -0.32 0.04554 mirMAP -0.14 0 NA
4 hsa-miR-182-5p ACVR1 3.54 0 -0.44 0.01143 MirTarget; miRNATAP -0.15 0 NA
5 hsa-miR-182-5p ACVRL1 3.54 0 -1.25 0 mirMAP -0.25 0 NA
6 hsa-miR-182-5p ADAM19 3.54 0 -1.06 0.01895 miRNATAP -0.53 0 NA
7 hsa-miR-182-5p ADAMTS18 3.54 0 -0.74 0.14599 miRNATAP -0.22 0.00048 NA
8 hsa-miR-182-5p ADAMTS4 3.54 0 -2.17 0 MirTarget -0.42 0 NA
9 hsa-miR-182-5p ADCY2 3.54 0 -3.87 0 miRNATAP -0.4 0 NA
10 hsa-miR-182-5p AFAP1 3.54 0 -0.98 0.00012 mirMAP -0.26 0 NA
11 hsa-miR-182-5p AFF2 3.54 0 -1.73 0.00201 mirMAP -0.22 0.00162 NA
12 hsa-miR-182-5p AK5 3.54 0 -1.18 0.03248 MirTarget -0.16 0.02037 NA
13 hsa-miR-182-5p AKAP7 3.54 0 -1.26 1.0E-5 miRNATAP -0.14 6.0E-5 NA
14 hsa-miR-182-5p AMOTL2 3.54 0 -1.01 0.00015 miRNATAP -0.24 0 NA
15 hsa-miR-182-5p ANK2 3.54 0 -4.32 0 miRNATAP -0.75 0 NA
16 hsa-miR-182-5p ANTXR2 3.54 0 -2.31 0 miRNATAP -0.45 0 NA
17 hsa-miR-182-5p ARHGAP6 3.54 0 -3.25 0 MirTarget -0.21 0.00033 NA
18 hsa-miR-182-5p ARHGEF3 3.54 0 -0.76 0 MirTarget -0.11 0 NA
19 hsa-miR-182-5p ARHGEF4 3.54 0 -1.44 0.0131 mirMAP -0.35 0 NA
20 hsa-miR-182-5p ARL4C 3.54 0 -0.28 0.33535 miRNATAP -0.19 0 NA
21 hsa-miR-182-5p ASAP1 3.54 0 0.06 0.77944 mirMAP -0.11 2.0E-5 NA
22 hsa-miR-182-5p ASB1 3.54 0 -0.87 0 mirMAP -0.16 0 NA
23 hsa-miR-182-5p ASXL3 3.54 0 -3.34 0 mirMAP -0.37 0 NA
24 hsa-miR-182-5p ATP10A 3.54 0 -0.81 0.03741 mirMAP -0.4 0 NA
25 hsa-miR-182-5p ATP10D 3.54 0 -0.69 0.01004 MirTarget -0.22 0 NA
26 hsa-miR-182-5p ATP2B4 3.54 0 -1.72 0 mirMAP -0.29 0 NA
27 hsa-miR-182-5p ATP8A1 3.54 0 -1.48 8.0E-5 MirTarget; miRNATAP -0.16 0.00055 NA
28 hsa-miR-182-5p ATXN1 3.54 0 -1.51 0 mirMAP; miRNATAP -0.31 0 NA
29 hsa-miR-182-5p B3GNT7 3.54 0 -0.34 0.37613 mirMAP -0.13 0.00434 NA
30 hsa-miR-182-5p BACE1 3.54 0 -0.72 0.00096 mirMAP -0.23 0 NA
31 hsa-miR-182-5p BACH2 3.54 0 -1.52 0.00134 MirTarget; mirMAP; miRNATAP -0.44 0 NA
32 hsa-miR-182-5p BCL2 3.54 0 -2.02 0 miRNAWalker2 validate; miRTarBase; mirMAP -0.18 0 23936432; 26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182
33 hsa-miR-182-5p BDNF 3.54 0 -2.91 0 MirTarget; miRNATAP -0.3 0 NA
34 hsa-miR-182-5p BHLHE22 3.54 0 -1.78 1.0E-5 MirTarget; miRNATAP -0.13 0.01116 NA
35 hsa-miR-182-5p BMPER 3.54 0 -2.38 0 MirTarget -0.31 0 NA
36 hsa-miR-182-5p BMPR1B 3.54 0 0.07 0.91404 MirTarget -0.35 1.0E-5 NA
37 hsa-miR-182-5p BNC2 3.54 0 -2.95 0 MirTarget; miRNATAP -0.72 0 NA
38 hsa-miR-182-5p BRMS1L 3.54 0 -0.51 0.00391 MirTarget -0.12 0 NA
39 hsa-miR-182-5p BTLA 3.54 0 -1.31 0.00559 MirTarget -0.38 0 NA
40 hsa-miR-182-5p C15orf52 3.54 0 -1.18 0.0026 mirMAP -0.16 0.00121 NA
41 hsa-miR-182-5p C17orf51 3.54 0 -0.68 0.02254 mirMAP -0.23 0 NA
42 hsa-miR-182-5p C1orf21 3.54 0 -1.51 0 mirMAP -0.14 0 NA
43 hsa-miR-182-5p CACNA2D1 3.54 0 -3.32 0 miRNATAP -0.8 0 NA
44 hsa-miR-182-5p CACNB2 3.54 0 -2.97 0 miRNATAP -0.37 0 NA
45 hsa-miR-182-5p CACNB4 3.54 0 -2.87 0 miRNATAP -0.32 0 NA
46 hsa-miR-182-5p CADM1 3.54 0 -1.19 0.01251 miRNATAP -0.14 0.01801 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo
47 hsa-miR-182-5p CADM2 3.54 0 -3.84 0 MirTarget; mirMAP; miRNATAP -0.26 0.00033 NA
48 hsa-miR-182-5p CALD1 3.54 0 -2.47 0 MirTarget -0.57 0 NA
49 hsa-miR-182-5p CBFA2T3 3.54 0 -1.56 2.0E-5 MirTarget; miRNATAP -0.1 0.02527 NA
50 hsa-miR-182-5p CBX6 3.54 0 -1.54 0 miRNAWalker2 validate -0.19 0 NA
51 hsa-miR-182-5p CCDC88A 3.54 0 -0.76 0.01199 miRNATAP -0.27 0 NA
52 hsa-miR-182-5p CCND2 3.54 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 0 NA
53 hsa-miR-182-5p CD209 3.54 0 -1.78 0.00035 mirMAP -0.64 0 NA
54 hsa-miR-182-5p CD226 3.54 0 -1.61 0.00025 MirTarget -0.43 0 NA
55 hsa-miR-182-5p CD274 3.54 0 0.06 0.90454 mirMAP -0.32 0 NA
56 hsa-miR-182-5p CD47 3.54 0 -0.16 0.4808 MirTarget; miRNATAP -0.13 0 NA
57 hsa-miR-182-5p CD59 3.54 0 -0.7 0.0013 MirTarget -0.14 0 NA
58 hsa-miR-182-5p CDC42BPA 3.54 0 -1.41 0 MirTarget; miRNATAP -0.19 0 NA
59 hsa-miR-182-5p CDC42EP3 3.54 0 -1.35 0 mirMAP -0.25 0 NA
60 hsa-miR-182-5p CDK6 3.54 0 -0.77 0.06479 mirMAP -0.34 0 NA
61 hsa-miR-182-5p CDKN1A 3.54 0 -1.29 0 miRNAWalker2 validate -0.11 0.00142 NA
62 hsa-miR-182-5p CDKN2C 3.54 0 0.23 0.43313 MirTarget -0.13 0.00017 NA
63 hsa-miR-182-5p CDV3 3.54 0 -0.42 0.0021 MirTarget; miRNATAP -0.13 0 NA
64 hsa-miR-182-5p CECR1 3.54 0 -0.68 0.05777 mirMAP -0.15 0.0004 NA
65 hsa-miR-182-5p CELF2 3.54 0 -3.05 0 mirMAP; miRNATAP -0.54 0 NA
66 hsa-miR-182-5p CHL1 3.54 0 -2.42 0.00043 MirTarget; miRNATAP -0.31 0.0003 24971532 miR 182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma; Bioinformatics analysis revealed close homolog of LI CHL1 as a potential target of miR-182; Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines; miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3'-untranslated region 3'-UTR; Silencing of CHL1 counteracted the effects of miR-182 suppression while its overexpression mimicked these effects; Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1 supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC
67 hsa-miR-182-5p CHST10 3.54 0 -0.67 0.06109 miRNATAP -0.16 0.00034 NA
68 hsa-miR-182-5p CHST11 3.54 0 0.54 0.2311 miRNATAP -0.37 0 NA
69 hsa-miR-182-5p CLIC5 3.54 0 -1.44 0.00056 miRNATAP -0.31 0 NA
70 hsa-miR-182-5p CLUAP1 3.54 0 -0.82 3.0E-5 miRNATAP -0.12 0 NA
71 hsa-miR-182-5p CNN3 3.54 0 -0.66 0.00535 MirTarget -0.16 0 NA
72 hsa-miR-182-5p CNTN1 3.54 0 -4.98 0 MirTarget; miRNATAP -0.87 0 NA
73 hsa-miR-182-5p COL4A4 3.54 0 -2.67 0 MirTarget -0.36 0 NA
74 hsa-miR-182-5p CORO1C 3.54 0 -1.12 0 MirTarget; miRNATAP -0.3 0 NA
75 hsa-miR-182-5p CPEB1 3.54 0 -4.68 0 miRNATAP -0.75 0 NA
76 hsa-miR-182-5p CREB3L1 3.54 0 -1.81 3.0E-5 MirTarget -0.39 0 NA
77 hsa-miR-182-5p CREB5 3.54 0 -2.28 0 mirMAP -0.46 0 NA
78 hsa-miR-182-5p CRISPLD2 3.54 0 -2.53 0 mirMAP -0.42 0 NA
79 hsa-miR-182-5p CSMD2 3.54 0 0.91 0.0162 mirMAP -0.22 0 NA
80 hsa-miR-182-5p CYLD 3.54 0 -0.89 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.17 0 27476169 We then demonstrated that knockdown of miR-182 up-regulated the expression of cylindromatosis CYLD deubiquitinase which promoted the formation of death-inducing signaling complex DISC and subsequent caspase-8 activation in TNF-α-treated BT-549 cells
81 hsa-miR-182-5p DAAM2 3.54 0 -2.23 0 mirMAP -0.38 0 NA
82 hsa-miR-182-5p DACT1 3.54 0 -1.78 2.0E-5 MirTarget -0.43 0 NA
83 hsa-miR-182-5p DENND5B 3.54 0 -1.35 0.0001 MirTarget; miRNATAP -0.33 0 NA
84 hsa-miR-182-5p DLG2 3.54 0 -3.8 0 miRNATAP -0.2 0.00137 NA
85 hsa-miR-182-5p DPF3 3.54 0 -1.67 1.0E-5 mirMAP -0.43 0 NA
86 hsa-miR-182-5p DTNA 3.54 0 -4.06 0 mirMAP -0.71 0 NA
87 hsa-miR-182-5p DUSP3 3.54 0 -1.04 0 mirMAP -0.22 0 NA
88 hsa-miR-182-5p DYNC1I1 3.54 0 -2.05 0.0001 MirTarget -0.23 0.00047 NA
89 hsa-miR-182-5p EBF1 3.54 0 -2.89 0 miRNATAP -0.42 0 NA
90 hsa-miR-182-5p EBF3 3.54 0 -2.22 0 MirTarget; miRNATAP -0.27 0 NA
91 hsa-miR-182-5p EDIL3 3.54 0 -1.4 0.00541 MirTarget -0.29 0 NA
92 hsa-miR-182-5p EDNRB 3.54 0 -2.52 0 miRNATAP -0.22 0 NA
93 hsa-miR-182-5p EGR3 3.54 0 -4.25 0 MirTarget -0.52 0 NA
94 hsa-miR-182-5p EIF4E3 3.54 0 -1.31 0 mirMAP -0.11 7.0E-5 NA
95 hsa-miR-182-5p EIF5A2 3.54 0 -1.12 0.00497 mirMAP -0.35 0 NA
96 hsa-miR-182-5p ELL2 3.54 0 -1.08 1.0E-5 MirTarget; miRNATAP -0.2 0 NA
97 hsa-miR-182-5p ELMO1 3.54 0 -1.21 6.0E-5 MirTarget -0.3 0 NA
98 hsa-miR-182-5p ENTPD1 3.54 0 -1.12 0 mirMAP -0.26 0 NA
99 hsa-miR-182-5p EOMES 3.54 0 -0.65 0.19494 MirTarget -0.34 0 NA
100 hsa-miR-182-5p EPDR1 3.54 0 -1.64 0.00035 MirTarget -0.47 0 NA
101 hsa-miR-182-5p EPHA3 3.54 0 -3.18 0 miRNATAP -0.43 0 NA
102 hsa-miR-182-5p EPHA7 3.54 0 -4.2 0 miRNATAP -0.29 0.00012 NA
103 hsa-miR-182-5p EPHB1 3.54 0 -2.07 0 MirTarget; miRNATAP -0.41 0 NA
104 hsa-miR-182-5p EPM2A 3.54 0 -1.9 0 miRNATAP -0.25 0 NA
105 hsa-miR-182-5p EPYC 3.54 0 2.07 0.00523 MirTarget -0.36 7.0E-5 NA
106 hsa-miR-182-5p ERG 3.54 0 -1.35 0 mirMAP -0.27 0 NA
107 hsa-miR-182-5p F13A1 3.54 0 -2.67 0 miRNATAP -0.6 0 NA
108 hsa-miR-182-5p FAM107A 3.54 0 -5.01 0 MirTarget -0.48 0 NA
109 hsa-miR-182-5p FAM124A 3.54 0 -2.09 0 mirMAP -0.47 0 NA
110 hsa-miR-182-5p FAM134B 3.54 0 -1.39 0.00067 MirTarget; miRNATAP -0.19 0.00013 NA
111 hsa-miR-182-5p FAM167A 3.54 0 0.27 0.48779 miRNATAP -0.17 0.00044 NA
112 hsa-miR-182-5p FAM168A 3.54 0 -0.72 0.00481 MirTarget -0.16 0 NA
113 hsa-miR-182-5p FAM171A1 3.54 0 -1.6 4.0E-5 miRNATAP -0.2 2.0E-5 NA
114 hsa-miR-182-5p FAM26E 3.54 0 -1.51 4.0E-5 mirMAP -0.43 0 NA
115 hsa-miR-182-5p FAM78A 3.54 0 -0.18 0.57167 MirTarget; miRNATAP -0.27 0 NA
116 hsa-miR-182-5p FAT3 3.54 0 -2.79 0 mirMAP -0.31 3.0E-5 NA
117 hsa-miR-182-5p FBN1 3.54 0 -1.82 5.0E-5 miRNATAP -0.55 0 NA
118 hsa-miR-182-5p FBXO32 3.54 0 -0.93 0.00122 mirMAP -0.37 0 NA
119 hsa-miR-182-5p FER 3.54 0 -0.96 0.00017 mirMAP -0.21 0 NA
120 hsa-miR-182-5p FGF9 3.54 0 -4.26 0 miRTarBase; miRNATAP -0.2 0.00291 NA
121 hsa-miR-182-5p FMNL3 3.54 0 0.14 0.461 miRNAWalker2 validate -0.15 0 NA
122 hsa-miR-182-5p FMO2 3.54 0 -2.41 0.00014 MirTarget -0.65 0 NA
123 hsa-miR-182-5p FOXN3 3.54 0 -1.44 0 MirTarget; miRNATAP -0.15 0 NA
124 hsa-miR-182-5p FOXO1 3.54 0 -1.06 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.13 0 24865442; 26640590; 23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1
125 hsa-miR-182-5p FOXP2 3.54 0 -3.99 0 miRNATAP -0.53 0 NA
126 hsa-miR-182-5p FYCO1 3.54 0 -1.62 0 miRNATAP -0.18 0 NA
127 hsa-miR-182-5p GAS7 3.54 0 -2.67 0 mirMAP -0.56 0 NA
128 hsa-miR-182-5p GCNT1 3.54 0 0.04 0.92747 miRNATAP -0.27 0 NA
129 hsa-miR-182-5p GFOD1 3.54 0 -0.94 0.00661 mirMAP -0.33 0 NA
130 hsa-miR-182-5p GIMAP1 3.54 0 -1.24 6.0E-5 MirTarget -0.37 0 NA
131 hsa-miR-182-5p GJC1 3.54 0 -0.97 0.00222 mirMAP -0.24 0 NA
132 hsa-miR-182-5p GLB1L 3.54 0 -0.51 0.00565 MirTarget -0.14 0 NA
133 hsa-miR-182-5p GLI2 3.54 0 -2.29 0 MirTarget -0.51 0 NA
134 hsa-miR-182-5p GNG7 3.54 0 -3.48 0 mirMAP -0.33 0 NA
135 hsa-miR-182-5p GPR132 3.54 0 -0.61 0.10569 mirMAP -0.34 0 NA
136 hsa-miR-182-5p GPR183 3.54 0 -2.34 0 MirTarget -0.51 0 NA
137 hsa-miR-182-5p GPR3 3.54 0 -0.96 0.00053 mirMAP -0.13 0.00022 NA
138 hsa-miR-182-5p GPRASP2 3.54 0 -1.46 0 miRNATAP -0.2 0 NA
139 hsa-miR-182-5p GRIA3 3.54 0 -2.07 7.0E-5 miRNATAP -0.45 0 NA
140 hsa-miR-182-5p GRID1 3.54 0 -0.62 0.16867 miRNATAP -0.19 0.00039 NA
141 hsa-miR-182-5p GRIN2A 3.54 0 -3.32 0 mirMAP -0.43 0 NA
142 hsa-miR-182-5p GRIN3A 3.54 0 -0.24 0.40319 mirMAP -0.2 0 NA
143 hsa-miR-182-5p GXYLT2 3.54 0 -1.72 0.00323 MirTarget -0.68 0 NA
144 hsa-miR-182-5p HBEGF 3.54 0 -2.26 0 MirTarget; miRNATAP -0.25 0 NA
145 hsa-miR-182-5p HDAC9 3.54 0 -1.52 0.00072 miRNATAP -0.39 0 26858310 HDAC Inhibition Induces MicroRNA 182 which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia; HR reporter assays apoptotic assays and colony-forming assays established that the miR-182 as well as the HDAC inhibition-mediated decreases in RAD51 inhibited HR repair and sensitized cells to sapacitabine; HDAC inhibition induced miR-182 in AML cell lines and primary AML blasts; Overexpression of miR-182 as well as HDAC inhibition-mediated induction of miR-182 were linked to time- and dose-dependent decreases in the levels of RAD51 an inhibition of HR increased levels of residual damage and decreased survival after exposure to double-strand damage-inducing agents; Our findings define the mechanism by which HDAC inhibition induces miR-182 to target RAD51 and highlights a novel pharmacologic strategy that compromises the ability of AML cells to conduct HR thereby sensitizing AML cells to DNA-damaging agents that activate HR as a repair and potential resistance mechanism
146 hsa-miR-182-5p HIF3A 3.54 0 -4.98 0 mirMAP -0.6 0 NA
147 hsa-miR-182-5p HLA-DOA 3.54 0 -0.79 0.07866 mirMAP -0.36 0 NA
148 hsa-miR-182-5p HMCN1 3.54 0 -0.31 0.47227 MirTarget -0.33 0 NA
149 hsa-miR-182-5p HOXA9 3.54 0 -1 0.05496 miRNATAP -0.15 0.02061 NA
150 hsa-miR-182-5p HSPA13 3.54 0 -0.29 0.10635 miRNATAP -0.1 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 70 1275 6.771e-16 3.151e-12
2 CELL DEVELOPMENT 70 1426 1.755e-13 4.084e-10
3 LOCOMOTION 57 1114 8.73e-12 1.354e-08
4 REGULATION OF CELL DIFFERENTIATION 68 1492 1.245e-11 1.448e-08
5 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 36 513 1.796e-11 1.671e-08
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 71 1672 1.014e-10 7.717e-08
7 CELLULAR COMPONENT MORPHOGENESIS 48 900 1.161e-10 7.717e-08
8 REGULATION OF CELLULAR COMPONENT MOVEMENT 43 771 3.002e-10 1.746e-07
9 CARDIOVASCULAR SYSTEM DEVELOPMENT 43 788 5.88e-10 2.736e-07
10 CIRCULATORY SYSTEM DEVELOPMENT 43 788 5.88e-10 2.736e-07
11 REGULATION OF ACTIN FILAMENT BASED PROCESS 25 312 1.692e-09 7.156e-07
12 CELL MOTILITY 43 835 3.387e-09 1.145e-06
13 LOCALIZATION OF CELL 43 835 3.387e-09 1.145e-06
14 TISSUE DEVELOPMENT 63 1518 3.444e-09 1.145e-06
15 REGULATION OF CELL ADHESION 36 629 4.73e-09 1.467e-06
16 NEUROGENESIS 59 1402 7.123e-09 2.071e-06
17 BIOLOGICAL ADHESION 48 1032 1.023e-08 2.799e-06
18 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 26 368 1.112e-08 2.874e-06
19 REGULATION OF ADHERENS JUNCTION ORGANIZATION 10 50 2.917e-08 7.142e-06
20 REGULATION OF CELL DEVELOPMENT 41 836 3.169e-08 7.373e-06
21 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 49 1142 8.812e-08 1.952e-05
22 REGULATION OF NEURON DIFFERENTIATION 31 554 9.687e-08 2.049e-05
23 VASCULATURE DEVELOPMENT 28 469 1.1e-07 2.226e-05
24 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 37 750 1.346e-07 2.609e-05
25 INTRACELLULAR SIGNAL TRANSDUCTION 60 1572 1.708e-07 3.179e-05
26 REGULATION OF CELLULAR COMPONENT BIOGENESIS 37 767 2.345e-07 4.196e-05
27 NEURON PROJECTION MORPHOGENESIS 25 402 2.507e-07 4.32e-05
28 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 43 983 3.491e-07 5.801e-05
29 POSITIVE REGULATION OF CELL DIFFERENTIATION 38 823 4.759e-07 7.636e-05
30 CELL JUNCTION ORGANIZATION 16 185 5.445e-07 8.446e-05
31 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 5.917e-07 8.851e-05
32 REGULATION OF CELL JUNCTION ASSEMBLY 10 68 6.087e-07 8.851e-05
33 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 43 1021 9.583e-07 0.0001351
34 REGULATION OF CELL MATRIX ADHESION 11 90 1.124e-06 0.0001538
35 NEURON DEVELOPMENT 33 687 1.194e-06 0.0001587
36 ACTION POTENTIAL 11 94 1.742e-06 0.0002191
37 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 42 1008 1.703e-06 0.0002191
38 MEMBRANE DEPOLARIZATION 9 61 2.175e-06 0.000231
39 ACTIN FILAMENT BASED PROCESS 25 450 1.984e-06 0.000231
40 NEURON PROJECTION DEVELOPMENT 28 545 2.213e-06 0.000231
41 REGULATION OF CHONDROCYTE DIFFERENTIATION 8 46 2.234e-06 0.000231
42 PROTEIN PHOSPHORYLATION 40 944 2.033e-06 0.000231
43 MUSCLE SYSTEM PROCESS 19 282 2.197e-06 0.000231
44 NEURON DIFFERENTIATION 38 874 2.034e-06 0.000231
45 NEURON PROJECTION GUIDANCE 16 205 2.13e-06 0.000231
46 REGULATION OF CELL ACTIVATION 26 484 2.293e-06 0.0002319
47 POSITIVE REGULATION OF CELL PROLIFERATION 36 814 2.611e-06 0.0002531
48 MUSCLE CONTRACTION 17 233 2.588e-06 0.0002531
49 EPITHELIAL CELL DEVELOPMENT 15 186 2.958e-06 0.0002809
50 EPITHELIAL CELL DIFFERENTIATION 26 495 3.45e-06 0.0003211
51 RESPONSE TO ENDOGENOUS STIMULUS 53 1450 3.576e-06 0.0003263
52 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 24 437 3.881e-06 0.0003284
53 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 63 1848 3.854e-06 0.0003284
54 MESENCHYME DEVELOPMENT 15 190 3.848e-06 0.0003284
55 STEM CELL DIFFERENTIATION 15 190 3.848e-06 0.0003284
56 POSITIVE REGULATION OF GENE EXPRESSION 60 1733 4.217e-06 0.0003407
57 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 4.247e-06 0.0003407
58 MULTICELLULAR ORGANISMAL SIGNALING 12 123 4.135e-06 0.0003407
59 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 35 799 4.468e-06 0.0003507
60 REGULATION OF PHOSPHORUS METABOLIC PROCESS 57 1618 4.522e-06 0.0003507
61 REGULATION OF CELL SUBSTRATE ADHESION 14 173 6.071e-06 0.0004631
62 REGULATION OF CELL MORPHOGENESIS 27 552 8.29e-06 0.0006221
63 REGULATION OF CELL PROLIFERATION 53 1496 8.736e-06 0.0006452
64 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 16 8.979e-06 0.0006528
65 MESENCHYMAL CELL DIFFERENTIATION 12 134 1.004e-05 0.0007189
66 CELL PROJECTION ORGANIZATION 37 902 1.04e-05 0.0007329
67 TAXIS 24 464 1.063e-05 0.0007385
68 ACTIN FILAMENT BASED MOVEMENT 10 93 1.109e-05 0.0007589
69 HEART DEVELOPMENT 24 466 1.142e-05 0.0007699
70 EPITHELIUM DEVELOPMENT 38 945 1.229e-05 0.0008166
71 CARDIAC MUSCLE CELL CONTRACTION 6 29 1.506e-05 0.0009871
72 REGULATION OF SYNAPSE ASSEMBLY 9 79 1.91e-05 0.001234
73 REGULATION OF PROTEIN MODIFICATION PROCESS 57 1710 2.295e-05 0.001463
74 REGULATION OF HEART CONTRACTION 15 221 2.364e-05 0.001467
75 TUBE DEVELOPMENT 26 552 2.337e-05 0.001467
76 REGULATION OF CARTILAGE DEVELOPMENT 8 63 2.501e-05 0.001511
77 BLOOD VESSEL MORPHOGENESIS 20 364 2.478e-05 0.001511
78 REGULATION OF TRANSMEMBRANE TRANSPORT 22 426 2.541e-05 0.001516
79 POSITIVE REGULATION OF NEURON DIFFERENTIATION 18 306 2.58e-05 0.00152
80 REGULATION OF CELL PROJECTION ORGANIZATION 26 558 2.808e-05 0.001633
81 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 33 801 2.924e-05 0.00168
82 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 5 20 2.993e-05 0.001698
83 MUSCLE STRUCTURE DEVELOPMENT 22 432 3.139e-05 0.00176
84 CELL PART MORPHOGENESIS 28 633 3.499e-05 0.001938
85 CELL JUNCTION ASSEMBLY 11 129 3.709e-05 0.00203
86 REGULATION OF CYTOSKELETON ORGANIZATION 24 502 3.808e-05 0.00206
87 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 58 1784 3.933e-05 0.002103
88 REGULATION OF NEURON PROJECTION DEVELOPMENT 21 408 4.067e-05 0.00215
89 REGULATION OF SYSTEM PROCESS 24 507 4.454e-05 0.002329
90 REGULATION OF CELL DEATH 50 1472 4.818e-05 0.002491
91 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 48 1395 5.045e-05 0.002551
92 POST EMBRYONIC DEVELOPMENT 9 89 4.991e-05 0.002551
93 MUSCLE CELL DIFFERENTIATION 15 237 5.299e-05 0.002651
94 ENDOTHELIUM DEVELOPMENT 9 90 5.453e-05 0.002671
95 ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 9 90 5.453e-05 0.002671
96 REGULATION OF SYNAPSE ORGANIZATION 10 113 6.087e-05 0.00295
97 POSITIVE REGULATION OF LOCOMOTION 21 420 6.166e-05 0.002958
98 CELLULAR RESPONSE TO HORMONE STIMULUS 25 552 6.328e-05 0.003005
99 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 6.482e-05 0.003047
100 ENDOTHELIAL CELL DIFFERENTIATION 8 72 6.661e-05 0.003099
101 NEGATIVE REGULATION OF GENE EXPRESSION 50 1493 6.883e-05 0.003171
102 CELLULAR RESPONSE TO LIPID 22 457 7.23e-05 0.003298
103 SENSORY ORGAN DEVELOPMENT 23 493 7.983e-05 0.003606
104 ACTIN MEDIATED CELL CONTRACTION 8 74 8.115e-05 0.00363
105 PHOSPHORYLATION 43 1228 8.669e-05 0.003842
106 SENSORY PERCEPTION OF PAIN 8 75 8.935e-05 0.003903
107 CARDIOCYTE DIFFERENTIATION 9 96 9.058e-05 0.003903
108 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 30 740 9.046e-05 0.003903
109 REGULATION OF MEMBRANE POTENTIAL 18 343 0.0001124 0.004799
110 REGULATION OF IMMUNE SYSTEM PROCESS 47 1403 0.000115 0.004835
111 POSITIVE REGULATION OF CELL DEVELOPMENT 22 472 0.0001153 0.004835
112 NEGATIVE REGULATION OF CELL DIFFERENTIATION 26 609 0.0001183 0.004913
113 REGULATION OF CELL CELL ADHESION 19 380 0.0001372 0.00565
114 POSITIVE REGULATION OF SYNAPSE ASSEMBLY 7 61 0.0001552 0.006333
115 CARDIAC CONDUCTION 8 82 0.0001682 0.006804
116 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 207 0.0001786 0.007164
117 REGULATION OF BLOOD CIRCULATION 16 295 0.0001844 0.007333
118 RESPONSE TO HORMONE 33 893 0.0002288 0.009023
119 SMOOTH MUSCLE CELL DIFFERENTIATION 5 30 0.0002352 0.009045
120 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 5 30 0.0002352 0.009045
121 REGULATION OF MEMBRANE REPOLARIZATION 5 30 0.0002352 0.009045
122 CELL ACTIVATION 24 568 0.0002508 0.009411
123 ION TRANSMEMBRANE TRANSPORT 31 822 0.0002501 0.009411
124 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 48 1492 0.0002495 0.009411
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 64 1737 2.204e-07 0.0002047
2 ACTIN BINDING 24 393 6.066e-07 0.0002818
3 PROTEIN KINASE ACTIVITY 30 640 6.012e-06 0.001117
4 KINASE ACTIVITY 36 842 5.573e-06 0.001117
5 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 20 328 5.426e-06 0.001117
6 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 24 464 1.063e-05 0.001368
7 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 29 629 1.178e-05 0.001368
8 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 45 1199 1.088e-05 0.001368
9 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 9 81 2.341e-05 0.002417
10 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 15 226 3.068e-05 0.00285
11 CYTOSKELETAL PROTEIN BINDING 33 819 4.519e-05 0.003498
12 KINASE BINDING 27 606 4.272e-05 0.003498
13 GATED CHANNEL ACTIVITY 18 325 5.665e-05 0.004049
14 CATION CHANNEL ACTIVITY 17 298 6.312e-05 0.004188
15 MACROMOLECULAR COMPLEX BINDING 47 1399 0.0001076 0.006661
16 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 17 315 0.0001241 0.006794
17 GROWTH FACTOR BINDING 10 123 0.0001243 0.006794
18 CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 10 128 0.0001729 0.008453
19 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 36 992 0.0001689 0.008453
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 61 1151 3.178e-13 1.856e-10
2 INTRINSIC COMPONENT OF PLASMA MEMBRANE 65 1649 1.396e-08 4.077e-06
3 CELL PROJECTION 68 1786 2.396e-08 4.664e-06
4 ACTIN CYTOSKELETON 27 444 1.291e-07 1.885e-05
5 NEURON PART 49 1265 1.769e-06 0.0001872
6 PLASMA MEMBRANE PROTEIN COMPLEX 27 510 1.924e-06 0.0001872
7 NEURON PROJECTION 39 942 4.766e-06 0.0003534
8 CELL CELL JUNCTION 22 383 4.841e-06 0.0003534
9 SYNAPSE 33 754 8.626e-06 0.0005037
10 ANCHORING JUNCTION 25 489 8.501e-06 0.0005037
11 CELL CORTEX 16 238 1.431e-05 0.0006963
12 MEMBRANE REGION 43 1134 1.355e-05 0.0006963
13 T TUBULE 7 45 2.096e-05 0.0009414
14 CELL CORTEX PART 10 119 9.43e-05 0.003671
15 CYTOSKELETON 61 1967 9.416e-05 0.003671
16 VOLTAGE GATED SODIUM CHANNEL COMPLEX 4 14 0.0001115 0.004071
17 CYTOPLASMIC REGION 16 287 0.0001347 0.004369
18 POSTSYNAPSE 19 378 0.0001282 0.004369
19 SARCOLEMMA 10 125 0.0001421 0.004369
20 CORTICAL CYTOSKELETON 8 81 0.0001543 0.004505
21 POSTSYNAPTIC MEMBRANE 13 205 0.0001623 0.004512
22 RUFFLE 11 156 0.0002055 0.005454
23 SODIUM CHANNEL COMPLEX 4 17 0.0002535 0.006168
24 CELL SUBSTRATE JUNCTION 19 398 0.0002474 0.006168
25 CATION CHANNEL COMPLEX 11 167 0.00037 0.008644
26 INTERCALATED DISC 6 51 0.0004013 0.009014
27 CELL LEADING EDGE 17 350 0.0004261 0.009215
28 DENDRITE 20 451 0.0004439 0.009258
29 PLASMA MEMBRANE REGION 33 929 0.0004614 0.009292

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 15 200 7.199e-06 0.001296
2 hsa04151_PI3K_AKT_signaling_pathway 20 351 1.47e-05 0.001323
3 hsa04514_Cell_adhesion_molecules_.CAMs. 11 136 6.03e-05 0.003618
4 hsa04010_MAPK_signaling_pathway 15 268 0.0002076 0.00778
5 hsa04512_ECM.receptor_interaction 8 85 0.0002161 0.00778
6 hsa04020_Calcium_signaling_pathway 11 177 0.0006045 0.01618
7 hsa04014_Ras_signaling_pathway 13 236 0.0006294 0.01618
8 hsa04810_Regulation_of_actin_cytoskeleton 11 214 0.002773 0.06239
9 hsa04360_Axon_guidance 8 130 0.003488 0.06977
10 hsa04350_TGF.beta_signaling_pathway 6 85 0.005681 0.1023
11 hsa04270_Vascular_smooth_muscle_contraction 7 116 0.006819 0.1116
12 hsa04962_Vasopressin.regulated_water_reabsorption 4 44 0.009657 0.1404
13 hsa04115_p53_signaling_pathway 5 69 0.01014 0.1404
14 hsa04722_Neurotrophin_signaling_pathway 7 127 0.01096 0.1409
15 hsa04012_ErbB_signaling_pathway 5 87 0.02534 0.2876
16 hsa04310_Wnt_signaling_pathway 7 151 0.02583 0.2876
17 hsa04390_Hippo_signaling_pathway 7 154 0.02835 0.2876
18 hsa04062_Chemokine_signaling_pathway 8 189 0.02876 0.2876
19 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 2 15 0.03227 0.3057
20 hsa04912_GnRH_signaling_pathway 5 101 0.04397 0.3644
21 hsa04916_Melanogenesis 5 101 0.04397 0.3644
22 hsa04720_Long.term_potentiation 4 70 0.04454 0.3644
23 hsa04910_Insulin_signaling_pathway 6 138 0.04886 0.3798
24 hsa00310_Lysine_degradation 3 44 0.05117 0.3798
25 hsa04971_Gastric_acid_secretion 4 74 0.05274 0.3798
26 hsa04630_Jak.STAT_signaling_pathway 6 155 0.07653 0.5102
27 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.08461 0.5403
28 hsa04210_Apoptosis 4 89 0.09019 0.5403
29 hsa04970_Salivary_secretion 4 89 0.09019 0.5403
30 hsa04540_Gap_junction 4 90 0.09305 0.5403
31 hsa04380_Osteoclast_differentiation 5 128 0.09816 0.5521
32 hsa04520_Adherens_junction 3 73 0.1625 0.859
33 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.1719 0.859
34 hsa04114_Oocyte_meiosis 4 114 0.1731 0.859
35 hsa04145_Phagosome 5 156 0.1777 0.859
36 hsa04260_Cardiac_muscle_contraction 3 77 0.1813 0.859
37 hsa04670_Leukocyte_transendothelial_migration 4 117 0.1844 0.859
38 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.1861 0.859
39 hsa00230_Purine_metabolism 5 162 0.1972 0.8875
40 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.2183 0.9484
41 hsa04110_Cell_cycle 4 128 0.2278 0.9535
42 hsa04150_mTOR_signaling_pathway 2 52 0.2607 1
43 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 0.2608 1
44 hsa04340_Hedgehog_signaling_pathway 2 56 0.289 1
45 hsa04972_Pancreatic_secretion 3 101 0.3025 1
46 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.3077 1
47 hsa04144_Endocytosis 5 203 0.3448 1
48 hsa04610_Complement_and_coagulation_cascades 2 69 0.3795 1
49 hsa04730_Long.term_depression 2 70 0.3863 1
50 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.3931 1
51 hsa04976_Bile_secretion 2 71 0.3931 1
52 hsa04370_VEGF_signaling_pathway 2 76 0.4263 1
53 hsa04640_Hematopoietic_cell_lineage 2 88 0.5019 1
54 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.5429 1
55 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.6127 1
56 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.8328 1
57 hsa04740_Olfactory_transduction 2 388 0.9954 1

Quest ID: 82afc468027426d47a17cbeee1d8beab