This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-let-7b-5p | CCND3 | 0.14 | 0.15257 | -1.83 | 0.02652 | miRNAWalker2 validate | -1.84 | 0.00329 | ||
2 | hsa-miR-10a-5p | DVL1 | 0.05 | 0.70373 | 0 | 0 | miRNAWalker2 validate | -0.1 | 0.02959 | ||
3 | hsa-miR-155-5p | PSEN1 | 0.44 | 0.06086 | -2.36 | 0.01393 | miRNAWalker2 validate | -0.59 | 0.03354 | ||
4 | hsa-miR-155-5p | SMAD3 | 0.44 | 0.06086 | -1.06 | 0.0964 | miRNAWalker2 validate | -0.52 | 0.04683 | ||
5 | hsa-miR-16-5p | CAMK2G | 0.11 | 0.25452 | -1.61 | 0.13617 | miRNAWalker2 validate | -1.12 | 0.04008 | ||
6 | hsa-miR-16-5p | CCND3 | 0.11 | 0.25452 | -1.83 | 0.02652 | miRNAWalker2 validate; miRTarBase; miRNATAP | -1.81 | 0.00263 | ||
7 | hsa-miR-17-5p | SMAD3 | 0.44 | 0.00967 | -1.06 | 0.0964 | miRNAWalker2 validate | -0.71 | 0.04882 | ||
8 | hsa-miR-186-5p | CAMK2B | 1.11 | 0.19322 | -0.91 | 0.14436 | miRNAWalker2 validate; miRNATAP | -0.2 | 0.04684 | ||
9 | hsa-miR-194-5p | EP300 | -0.25 | 0.16359 | 0.67 | 0.2429 | miRNAWalker2 validate | -0.77 | 0.04574 | ||
10 | hsa-miR-21-5p | DAAM1 | 0.23 | 0.00828 | -0.87 | 0.14392 | miRNAWalker2 validate | -1.6 | 0.04408 | ||
11 | hsa-miR-27b-3p | CCND3 | 0.19 | 0.12698 | -1.83 | 0.02652 | miRNAWalker2 validate | -1.26 | 0.00118 | ||
12 | hsa-miR-324-5p | CCND3 | 0.58 | 0.02606 | -1.83 | 0.02652 | miRNAWalker2 validate | -0.52 | 0.00177 | ||
13 | hsa-miR-324-5p | VANGL1 | 0.58 | 0.02606 | -0.33 | 0.82527 | miRNAWalker2 validate | -0.18 | 0.01236 | ||
14 | hsa-miR-34a-5p | CCND3 | 0.19 | 0.17145 | -1.83 | 0.02652 | miRNAWalker2 validate | -0.95 | 0.00801 | ||
15 | hsa-miR-34a-5p | CTNNB1 | 0.19 | 0.17145 | 0 | 0 | miRNAWalker2 validate | -0.16 | 0.04451 | ||
16 | hsa-miR-361-3p | NFATC3 | 0.44 | 0.31285 | -0.06 | 0.94841 | miRNAWalker2 validate | -0.07 | 0.04129 | ||
17 | hsa-miR-424-5p | CCND3 | 0.62 | 0.00401 | -1.83 | 0.02652 | miRNAWalker2 validate; miRTarBase | -0.61 | 0.00184 | ||
18 | hsa-miR-98-5p | VANGL1 | 0.53 | 0.01502 | -0.33 | 0.82527 | miRNAWalker2 validate | -0.18 | 0.03777 | ||
19 | hsa-miR-98-5p | WNT10B | 0.53 | 0.01502 | -1.49 | 0.00278 | miRNAWalker2 validate | -0.77 | 0.03993 | ||
20 | hsa-let-7b-3p | DAAM1 | 0.68 | 0.01987 | -0.87 | 0.14392 | MirTarget | -0.37 | 0.03873 | ||
21 | hsa-let-7f-1-3p | DAAM1 | 0.66 | 0.00733 | -0.87 | 0.14392 | MirTarget | -0.42 | 0.04933 | ||
22 | hsa-miR-1224-5p | PSEN1 | 0.33 | 0.07543 | -2.36 | 0.01393 | MirTarget | -0.79 | 0.02807 | ||
23 | hsa-miR-1225-3p | CCND3 | 0.19 | 0.05199 | -1.83 | 0.02652 | MirTarget | -1.46 | 0.01737 | ||
24 | hsa-miR-130b-3p | DAAM1 | 0.73 | 0.00544 | -0.87 | 0.14392 | MirTarget; miRNATAP | -0.42 | 0.03451 | ||
25 | hsa-miR-140-5p | PSEN1 | 0.33 | 0.06517 | -2.36 | 0.01393 | MirTarget; miRanda | -0.97 | 0.00604 | ||
26 | hsa-miR-145-5p | SMAD3 | 0.59 | 0.13573 | -1.06 | 0.0964 | MirTarget; miRNATAP | -0.35 | 0.01824 | ||
27 | hsa-miR-145-5p | PPP3R2 | 0.59 | 0.13573 | -0.49 | 0.53667 | MirTarget | -0.28 | 0.03715 | ||
28 | hsa-miR-195-5p | NFATC3 | -0.07 | 0.70188 | -0.06 | 0.94841 | MirTarget; miRNATAP | -0.25 | 0.00847 | ||
29 | hsa-miR-197-3p | PPP2R5A | 0.32 | 0.06134 | -0.42 | 0.68036 | MirTarget | -0.44 | 0.00884 | ||
30 | hsa-miR-21-3p | PSEN1 | 0.68 | 0.00116 | -2.36 | 0.01393 | MirTarget | -0.68 | 0.01616 | ||
31 | hsa-miR-214-3p | PSEN1 | 0.81 | 0.00444 | -2.36 | 0.01393 | MirTarget | -0.54 | 0.00847 | ||
32 | hsa-miR-214-3p | PPP2CB | 0.81 | 0.00444 | -0.96 | 0.13485 | MirTarget | -0.51 | 0.00868 | ||
33 | hsa-miR-24-3p | CAMK2B | 0.28 | 0.01927 | -0.91 | 0.14436 | MirTarget | -2.01 | 0.00784 | ||
34 | hsa-miR-32-3p | PPP2CB | 0.5 | 0.02563 | -0.96 | 0.13485 | MirTarget | -0.64 | 0.01606 | ||
35 | hsa-miR-324-5p | PRKCG | 0.58 | 0.02606 | -1.63 | 0.17124 | MirTarget; PITA; miRanda; miRNATAP | -1.02 | 0.04462 | ||
36 | hsa-miR-335-3p | PSEN1 | 0.85 | 0.00062 | -2.36 | 0.01393 | MirTarget | -0.58 | 0.012 | ||
37 | hsa-miR-361-3p | CAMK2B | 0.44 | 0.31285 | -0.91 | 0.14436 | MirTarget; miRNATAP | -0.47 | 0.01257 | ||
38 | hsa-miR-497-5p | NFATC3 | -0.03 | 0.91972 | -0.06 | 0.94841 | MirTarget; miRNATAP | -0.14 | 0.0127 | ||
39 | hsa-miR-634 | DAAM1 | 0.59 | 0.05166 | -0.87 | 0.14392 | MirTarget | -0.43 | 0.01174 | ||
40 | hsa-miR-634 | CAMK2G | 0.59 | 0.05166 | -1.61 | 0.13617 | MirTarget; PITA; miRNATAP | -0.32 | 0.01115 | ||
41 | hsa-miR-7-5p | PRKCB | 0.82 | 0.00417 | -0.48 | 0.14744 | MirTarget; miRNATAP | -0.29 | 0.04774 | ||
42 | hsa-miR-940 | CCND3 | 0.17 | 0.08339 | -1.83 | 0.02652 | MirTarget; miRNATAP | -1.72 | 0.00443 | ||
43 | hsa-miR-940 | CAMK2B | 0.17 | 0.08339 | -0.91 | 0.14436 | PITA; miRNATAP | -2.49 | 0.02741 | ||
44 | hsa-miR-188-5p | WNT10B | 0.44 | 0.01154 | -1.49 | 0.00278 | PITA | -1.21 | 0.00985 | ||
45 | hsa-miR-940 | TBL1Y | 0.17 | 0.08339 | -1.26 | 0.04879 | PITA | -1.52 | 0.0302 | ||
46 | hsa-miR-17-5p | PSEN1 | 0.44 | 0.00967 | -2.36 | 0.01393 | TargetScan | -0.88 | 0.02046 | ||
47 | hsa-miR-17-5p | VANGL1 | 0.44 | 0.00967 | -0.33 | 0.82527 | TargetScan; miRNATAP | -0.26 | 0.02092 | ||
48 | hsa-miR-107 | PSEN1 | 0.21 | 0.08342 | -2.36 | 0.01393 | miRanda | -1.67 | 0.00394 | ||
49 | hsa-miR-199b-5p | CAMK2B | 0.61 | 0.02975 | -0.91 | 0.14436 | miRanda | -0.73 | 0.0112 | ||
50 | hsa-miR-320a | CCND3 | 0.13 | 0.34701 | -1.83 | 0.02652 | miRanda | -1.1 | 0.00267 | ||
51 | hsa-miR-320a | PSEN1 | 0.13 | 0.34701 | -2.36 | 0.01393 | miRanda; mirMAP | -1.06 | 0.04426 | ||
52 | hsa-miR-361-5p | PPP2CB | 0.45 | 0.0617 | -0.96 | 0.13485 | miRanda | -0.5 | 0.04519 | ||
53 | hsa-miR-361-5p | PSEN1 | 0.45 | 0.0617 | -2.36 | 0.01393 | miRanda | -0.66 | 0.01085 | ||
54 | hsa-miR-429 | PLCB4 | -0.09 | 0.68169 | 1.59 | 0.12874 | miRanda | -0.74 | 0.03555 | ||
55 | hsa-miR-590-5p | SOX17 | 0.14 | 0.54667 | 0.7 | 0.51439 | miRanda | -0.14 | 0.03712 | ||
56 | hsa-miR-1237-3p | CAMK2B | 0.52 | 0.00934 | -0.91 | 0.14436 | mirMAP | -1.2 | 0.00226 | ||
57 | hsa-miR-150-5p | CAMK2B | 0.26 | 0.33481 | -0.91 | 0.14436 | mirMAP | -0.75 | 0.01815 | ||
58 | hsa-miR-34a-5p | CAMK2B | 0.19 | 0.17145 | -0.91 | 0.14436 | mirMAP | -1.62 | 0.01313 | ||
59 | hsa-let-7b-3p | PSEN1 | 0.68 | 0.01987 | -2.36 | 0.01393 | mirMAP | -0.48 | 0.02272 | ||
60 | hsa-let-7f-1-3p | PSEN1 | 0.66 | 0.00733 | -2.36 | 0.01393 | mirMAP | -0.63 | 0.00902 | ||
61 | hsa-miR-1237-3p | PSEN1 | 0.52 | 0.00934 | -2.36 | 0.01393 | mirMAP | -0.68 | 0.03 | ||
62 | hsa-miR-136-5p | PSEN1 | 0.45 | 0.08353 | -2.36 | 0.01393 | mirMAP | -0.62 | 0.01014 | ||
63 | hsa-miR-197-3p | PSEN1 | 0.32 | 0.06134 | -2.36 | 0.01393 | mirMAP | -0.85 | 0.0322 | ||
64 | hsa-miR-29b-1-5p | PSEN1 | 0.79 | 0.00532 | -2.36 | 0.01393 | mirMAP | -0.52 | 0.01303 | ||
65 | hsa-miR-32-3p | PSEN1 | 0.5 | 0.02563 | -2.36 | 0.01393 | mirMAP | -0.64 | 0.02304 | ||
66 | hsa-miR-548c-5p | PSEN1 | 0.37 | 0.09194 | -2.36 | 0.01393 | mirMAP | -0.67 | 0.02249 | ||
67 | hsa-miR-548d-5p | PSEN1 | 0.23 | 0.18403 | -2.36 | 0.01393 | mirMAP | -0.92 | 0.01975 | ||
68 | hsa-miR-32-3p | DAAM1 | 0.5 | 0.02563 | -0.87 | 0.14392 | mirMAP | -0.52 | 0.03036 | ||
69 | hsa-miR-324-3p | PPARD | 0.45 | 0.05568 | -0.74 | 0.27453 | mirMAP | -0.68 | 0.0405 | ||
70 | hsa-miR-625-3p | PPARD | 0.71 | 0.00052 | -0.74 | 0.27453 | mirMAP | -0.75 | 0.03708 | ||
71 | hsa-miR-1228-3p | WNT9A | 0.12 | 0.13978 | -1.66 | 0.03538 | mirMAP | -5.09 | 0.04774 | ||
72 | hsa-miR-186-5p | TCF7L2 | 1.11 | 0.19322 | -1.35 | 0.12977 | mirMAP | -0.13 | 0.03029 | ||
73 | hsa-miR-590-5p | DVL3 | 0.14 | 0.54667 | 0 | 0 | mirMAP | -0.31 | 0.00237 | ||
74 | hsa-miR-1237-3p | PRKCB | 0.52 | 0.00934 | -0.48 | 0.14744 | mirMAP | -0.53 | 0.01103 | ||
75 | hsa-miR-29b-1-5p | PRKCB | 0.79 | 0.00532 | -0.48 | 0.14744 | mirMAP | -0.3 | 0.03959 | ||
76 | hsa-miR-1237-3p | SMAD3 | 0.52 | 0.00934 | -1.06 | 0.0964 | mirMAP | -0.78 | 0.00621 | ||
77 | hsa-miR-186-5p | SMAD3 | 1.11 | 0.19322 | -1.06 | 0.0964 | mirMAP | -0.16 | 0.01706 | ||
78 | hsa-miR-32-3p | SMAD3 | 0.5 | 0.02563 | -1.06 | 0.0964 | mirMAP | -0.7 | 0.00676 | ||
79 | hsa-miR-141-3p | VANGL1 | -0.11 | 0.50173 | -0.33 | 0.82527 | mirMAP | -0.28 | 0.03523 | ||
80 | hsa-miR-148a-3p | VANGL1 | 0.11 | 0.41246 | -0.33 | 0.82527 | mirMAP | -0.46 | 0.00323 | ||
81 | hsa-miR-16-5p | VANGL1 | 0.11 | 0.25452 | -0.33 | 0.82527 | mirMAP | -0.63 | 0.01485 | ||
82 | hsa-miR-19a-3p | VANGL1 | 0.29 | 0.05074 | -0.33 | 0.82527 | mirMAP | -0.33 | 0.01523 | ||
83 | hsa-miR-19b-3p | VANGL1 | 0.22 | 0.07368 | -0.33 | 0.82527 | mirMAP | -0.45 | 0.00947 | ||
84 | hsa-miR-200a-3p | VANGL1 | -0.03 | 0.87657 | -0.33 | 0.82527 | mirMAP | -0.29 | 0.02171 | ||
85 | hsa-miR-590-5p | VANGL1 | 0.14 | 0.54667 | -0.33 | 0.82527 | mirMAP | -0.19 | 0.03273 | ||
86 | hsa-miR-30b-5p | PPP3R2 | 0.14 | 0.41338 | -0.49 | 0.53667 | mirMAP | -0.67 | 0.04039 | ||
87 | hsa-miR-20b-5p | VANGL1 | 0.44 | 0.01538 | -0.33 | 0.82527 | miRNATAP | -0.26 | 0.01136 | ||
88 | hsa-miR-106b-5p | VANGL1 | 0.29 | 0.0333 | -0.33 | 0.82527 | miRNATAP | -0.39 | 0.0097 | ||
89 | hsa-miR-93-5p | VANGL1 | 0.52 | 0.00425 | -0.33 | 0.82527 | miRNATAP | -0.24 | 0.02304 | ||
90 | hsa-miR-29b-3p | CAMK2G | 0.2 | 0.12015 | -1.61 | 0.13617 | miRNATAP | -0.78 | 0.03009 | ||
91 | hsa-miR-324-3p | FZD9 | 0.45 | 0.05568 | -1.47 | 0.00832 | miRNATAP | -0.76 | 0.03309 | ||
92 | hsa-miR-150-5p | PPP2CB | 0.26 | 0.33481 | -0.96 | 0.13485 | miRNATAP | -0.63 | 0.00458 | ||
93 | hsa-miR-20a-5p | VANGL1 | 0.29 | 0.03283 | -0.33 | 0.82527 | miRNATAP | -0.39 | 0.00993 | ||
94 | hsa-miR-429 | VANGL1 | -0.09 | 0.68169 | -0.33 | 0.82527 | miRNATAP | -0.2 | 0.02998 | ||
95 | hsa-miR-10b-5p | CAMK2B | -0.1 | 0.56684 | -0.91 | 0.14436 | miRNATAP | -1.23 | 0.01915 | ||
96 | hsa-miR-15b-5p | CCND3 | 0.16 | 0.15019 | -1.83 | 0.02652 | miRNATAP | -1.42 | 0.00467 | ||
97 | hsa-miR-27a-3p | PSEN1 | 0.25 | 0.02787 | -2.36 | 0.01393 | miRNATAP | -1.87 | 0.00173 | ||
98 | hsa-miR-28-5p | CCND3 | 0.14 | 0.34859 | -1.83 | 0.02652 | miRNATAP | -0.99 | 0.00342 | ||
99 | hsa-miR-92a-3p | DAAM1 | 0.45 | 0.00539 | -0.87 | 0.14392 | miRNATAP | -0.79 | 0.01613 | ||
100 | hsa-miR-29a-3p | CAMK2G | 0.18 | 0.10677 | -1.61 | 0.13617 | miRNATAP | -0.95 | 0.02221 | ||
101 | hsa-miR-15a-5p | CCND3 | 0.14 | 0.21128 | -1.83 | 0.02652 | miRNATAP | -1.55 | 0.00152 | ||
102 | hsa-miR-107 | CAMK2G | 0.21 | 0.08342 | -1.61 | 0.13617 | miRNATAP | -0.76 | 0.04418 | ||
103 | hsa-miR-574-5p | CAMK2B | 0.31 | 0.04403 | -0.91 | 0.14436 | miRNATAP | -1.29 | 0.02435 | ||
104 | hsa-miR-27b-3p | PSEN1 | 0.19 | 0.12698 | -2.36 | 0.01393 | miRNATAP | -1.43 | 0.00951 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | CANONICAL WNT SIGNALING PATHWAY | 9 | 95 | 1.602e-15 | 7.453e-12 |
2 | WNT SIGNALING PATHWAY | 11 | 351 | 1.49e-13 | 3.466e-10 |
3 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 15 | 1672 | 9.364e-11 | 1.452e-07 |
4 | NON CANONICAL WNT SIGNALING PATHWAY | 7 | 140 | 3.064e-10 | 3.564e-07 |
5 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 12 | 1021 | 8.246e-10 | 7.674e-07 |
6 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 11 | 823 | 1.409e-09 | 1.092e-06 |
7 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 12 | 1142 | 2.95e-09 | 1.961e-06 |
8 | PROTEIN STABILIZATION | 6 | 131 | 1.125e-08 | 6.545e-06 |
9 | EMBRYONIC ORGAN MORPHOGENESIS | 7 | 279 | 3.697e-08 | 1.912e-05 |
10 | HEART DEVELOPMENT | 8 | 466 | 6.247e-08 | 2.907e-05 |
11 | LYMPHOCYTE ACTIVATION | 7 | 342 | 1.483e-07 | 5.757e-05 |
12 | NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 9 | 740 | 1.485e-07 | 5.757e-05 |
13 | EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING | 8 | 554 | 2.352e-07 | 7.358e-05 |
14 | REGULATION OF PROTEIN STABILITY | 6 | 221 | 2.527e-07 | 7.358e-05 |
15 | CARDIOVASCULAR SYSTEM DEVELOPMENT | 9 | 788 | 2.53e-07 | 7.358e-05 |
16 | CIRCULATORY SYSTEM DEVELOPMENT | 9 | 788 | 2.53e-07 | 7.358e-05 |
17 | CELL ACTIVATION | 8 | 568 | 2.844e-07 | 7.533e-05 |
18 | POSITIVE REGULATION OF GENE EXPRESSION | 12 | 1733 | 3.076e-07 | 7.533e-05 |
19 | CELL FATE COMMITMENT | 6 | 227 | 2.959e-07 | 7.533e-05 |
20 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 11 | 1395 | 3.27e-07 | 7.609e-05 |
21 | REGULATION OF CANONICAL WNT SIGNALING PATHWAY | 6 | 236 | 3.719e-07 | 8.239e-05 |
22 | ORGAN MORPHOGENESIS | 9 | 841 | 4.383e-07 | 8.866e-05 |
23 | REGULATION OF ORGAN MORPHOGENESIS | 6 | 242 | 4.309e-07 | 8.866e-05 |
24 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 12 | 1805 | 4.792e-07 | 8.918e-05 |
25 | EMBRYONIC ORGAN DEVELOPMENT | 7 | 406 | 4.729e-07 | 8.918e-05 |
26 | LEUKOCYTE ACTIVATION | 7 | 414 | 5.392e-07 | 9.65e-05 |
27 | REGULATION OF CELL DIFFERENTIATION | 11 | 1492 | 6.429e-07 | 0.0001108 |
28 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 12 | 1929 | 9.833e-07 | 0.0001634 |
29 | REGULATION OF BINDING | 6 | 283 | 1.075e-06 | 0.0001725 |
30 | POSITIVE REGULATION OF CELL DEVELOPMENT | 7 | 472 | 1.297e-06 | 0.0002012 |
31 | POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 5 | 162 | 1.527e-06 | 0.0002293 |
32 | SENSORY ORGAN DEVELOPMENT | 7 | 493 | 1.733e-06 | 0.000252 |
33 | REGULATION OF WNT SIGNALING PATHWAY | 6 | 310 | 1.825e-06 | 0.0002574 |
34 | EMBRYONIC HEART TUBE DEVELOPMENT | 4 | 73 | 1.949e-06 | 0.0002592 |
35 | POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS | 3 | 20 | 1.939e-06 | 0.0002592 |
36 | TUBE MORPHOGENESIS | 6 | 323 | 2.315e-06 | 0.0002993 |
37 | BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY | 3 | 22 | 2.616e-06 | 0.0003289 |
38 | REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 6 | 337 | 2.958e-06 | 0.0003622 |
39 | EMBRYONIC MORPHOGENESIS | 7 | 539 | 3.131e-06 | 0.0003735 |
40 | ANTERIOR POSTERIOR PATTERN SPECIFICATION | 5 | 194 | 3.701e-06 | 0.0004089 |
41 | TUBE DEVELOPMENT | 7 | 552 | 3.664e-06 | 0.0004089 |
42 | REGULATION OF CELLULAR PROTEIN LOCALIZATION | 7 | 552 | 3.664e-06 | 0.0004089 |
43 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 11 | 1784 | 3.779e-06 | 0.0004089 |
44 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 11 | 1791 | 3.927e-06 | 0.0004152 |
45 | SKELETAL SYSTEM MORPHOGENESIS | 5 | 201 | 4.401e-06 | 0.000455 |
46 | POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS | 10 | 1492 | 5.984e-06 | 0.0006053 |
47 | NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS | 10 | 1517 | 6.942e-06 | 0.0006655 |
48 | REGULATION OF PROTEIN CATABOLIC PROCESS | 6 | 393 | 7.152e-06 | 0.0006655 |
49 | NEGATIVE REGULATION OF CELL DEATH | 8 | 872 | 7.055e-06 | 0.0006655 |
50 | NEGATIVE REGULATION OF CELL DIFFERENTIATION | 7 | 609 | 6.989e-06 | 0.0006655 |
51 | POSITIVE REGULATION OF CELL COMMUNICATION | 10 | 1532 | 7.58e-06 | 0.0006779 |
52 | REGULATION OF MUSCLE TISSUE DEVELOPMENT | 4 | 103 | 7.722e-06 | 0.0006779 |
53 | REGULATION OF MUSCLE ORGAN DEVELOPMENT | 4 | 103 | 7.722e-06 | 0.0006779 |
54 | MORPHOGENESIS OF AN EPITHELIUM | 6 | 400 | 7.911e-06 | 0.0006816 |
55 | EMBRYO DEVELOPMENT | 8 | 894 | 8.471e-06 | 0.0007166 |
56 | REGULATION OF ESTABLISHMENT OF PLANAR POLARITY | 4 | 110 | 1.002e-05 | 0.0008215 |
57 | POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION | 3 | 34 | 1.006e-05 | 0.0008215 |
58 | REGULATION OF EMBRYONIC DEVELOPMENT | 4 | 114 | 1.155e-05 | 0.0009263 |
59 | NEGATIVE REGULATION OF CELL CYCLE | 6 | 433 | 1.242e-05 | 0.0009797 |
60 | MYOBLAST DIFFERENTIATION | 3 | 37 | 1.303e-05 | 0.0009964 |
61 | CELL PROLIFERATION | 7 | 672 | 1.328e-05 | 0.0009964 |
62 | REGULATION OF PROTEIN LOCALIZATION | 8 | 950 | 1.321e-05 | 0.0009964 |
63 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 8 | 957 | 1.393e-05 | 0.001029 |
64 | SKELETAL SYSTEM DEVELOPMENT | 6 | 455 | 1.645e-05 | 0.001196 |
65 | CELL CYCLE | 9 | 1316 | 1.753e-05 | 0.001255 |
66 | HEPATICOBILIARY SYSTEM DEVELOPMENT | 4 | 128 | 1.824e-05 | 0.001286 |
67 | REGULATION OF PROTEOLYSIS | 7 | 711 | 1.913e-05 | 0.001328 |
68 | REGULATION OF GLYCOPROTEIN METABOLIC PROCESS | 3 | 43 | 2.06e-05 | 0.001389 |
69 | BETA CATENIN TCF COMPLEX ASSEMBLY | 3 | 43 | 2.06e-05 | 0.001389 |
70 | REGULATION OF CATABOLIC PROCESS | 7 | 731 | 2.288e-05 | 0.001499 |
71 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 9 | 1360 | 2.282e-05 | 0.001499 |
72 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 8 | 1036 | 2.476e-05 | 0.001578 |
73 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 8 | 1036 | 2.476e-05 | 0.001578 |
74 | REGULATION OF CHONDROCYTE DIFFERENTIATION | 3 | 46 | 2.528e-05 | 0.001589 |
75 | DIGESTIVE TRACT MORPHOGENESIS | 3 | 48 | 2.875e-05 | 0.001784 |
76 | REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT | 3 | 50 | 3.253e-05 | 0.001916 |
77 | DIGESTIVE SYSTEM DEVELOPMENT | 4 | 148 | 3.227e-05 | 0.001916 |
78 | POSITIVE REGULATION OF STEM CELL DIFFERENTIATION | 3 | 50 | 3.253e-05 | 0.001916 |
79 | REGULATION OF TRANSPORT | 10 | 1804 | 3.2e-05 | 0.001916 |
80 | NEURAL TUBE DEVELOPMENT | 4 | 149 | 3.313e-05 | 0.001927 |
81 | CELL CYCLE PROCESS | 8 | 1081 | 3.362e-05 | 0.001931 |
82 | REGIONALIZATION | 5 | 311 | 3.623e-05 | 0.002056 |
83 | GASTRULATION | 4 | 155 | 3.867e-05 | 0.002168 |
84 | TISSUE MORPHOGENESIS | 6 | 533 | 4.006e-05 | 0.002219 |
85 | NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS | 7 | 801 | 4.111e-05 | 0.00225 |
86 | REGULATION OF CELL DEATH | 9 | 1472 | 4.28e-05 | 0.002316 |
87 | NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY | 4 | 162 | 4.595e-05 | 0.002457 |
88 | NEGATIVE REGULATION OF GENE EXPRESSION | 9 | 1493 | 4.786e-05 | 0.002502 |
89 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 8 | 1135 | 4.766e-05 | 0.002502 |
90 | REGULATION OF CELL MORPHOGENESIS | 6 | 552 | 4.87e-05 | 0.002518 |
91 | REGULATION OF PROTEIN BINDING | 4 | 168 | 5.294e-05 | 0.002651 |
92 | POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 8 | 1152 | 5.298e-05 | 0.002651 |
93 | RESPONSE TO CARBOHYDRATE | 4 | 168 | 5.294e-05 | 0.002651 |
94 | REGULATION OF CELL DEVELOPMENT | 7 | 836 | 5.397e-05 | 0.002672 |
95 | TISSUE DEVELOPMENT | 9 | 1518 | 5.455e-05 | 0.002672 |
96 | STEM CELL PROLIFERATION | 3 | 60 | 5.633e-05 | 0.00273 |
97 | SOMITOGENESIS | 3 | 62 | 6.215e-05 | 0.002951 |
98 | EMBRYONIC HEART TUBE MORPHOGENESIS | 3 | 62 | 6.215e-05 | 0.002951 |
99 | REGULATION OF CARTILAGE DEVELOPMENT | 3 | 63 | 6.52e-05 | 0.003011 |
100 | IMMUNE SYSTEM DEVELOPMENT | 6 | 582 | 6.536e-05 | 0.003011 |
101 | REGULATION OF MUSCLE ADAPTATION | 3 | 63 | 6.52e-05 | 0.003011 |
102 | NEGATIVE REGULATION OF CELL COMMUNICATION | 8 | 1192 | 6.751e-05 | 0.00308 |
103 | INTRACELLULAR SIGNAL TRANSDUCTION | 9 | 1572 | 7.176e-05 | 0.00318 |
104 | CELLULAR RESPONSE TO RETINOIC ACID | 3 | 65 | 7.16e-05 | 0.00318 |
105 | REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS | 4 | 181 | 7.074e-05 | 0.00318 |
106 | IMMUNE SYSTEM PROCESS | 10 | 1984 | 7.271e-05 | 0.003192 |
107 | REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 5 | 365 | 7.747e-05 | 0.003369 |
108 | REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION | 3 | 67 | 7.84e-05 | 0.003378 |
109 | ENDODERM DEVELOPMENT | 3 | 71 | 9.323e-05 | 0.003944 |
110 | CELL FATE SPECIFICATION | 3 | 71 | 9.323e-05 | 0.003944 |
111 | NEGATIVE REGULATION OF WNT SIGNALING PATHWAY | 4 | 197 | 9.821e-05 | 0.004117 |
112 | NEGATIVE REGULATION OF MITOTIC CELL CYCLE | 4 | 199 | 0.0001021 | 0.004243 |
113 | REGULATION OF CELLULAR LOCALIZATION | 8 | 1277 | 0.0001097 | 0.004517 |
114 | EPITHELIUM DEVELOPMENT | 7 | 945 | 0.0001169 | 0.004647 |
115 | REGULATION OF CELLULAR RESPONSE TO HEAT | 3 | 76 | 0.0001142 | 0.004647 |
116 | REGULATION OF SKELETAL MUSCLE ADAPTATION | 2 | 13 | 0.000116 | 0.004647 |
117 | ENDODERMAL CELL FATE COMMITMENT | 2 | 13 | 0.000116 | 0.004647 |
118 | REGULATION OF CELL CYCLE | 7 | 949 | 0.00012 | 0.004731 |
119 | SOMITE DEVELOPMENT | 3 | 78 | 0.0001234 | 0.004824 |
120 | HEART MORPHOGENESIS | 4 | 212 | 0.0001304 | 0.005054 |
121 | REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE | 2 | 14 | 0.0001353 | 0.005159 |
122 | EMBRYONIC SKELETAL JOINT DEVELOPMENT | 2 | 14 | 0.0001353 | 0.005159 |
123 | REGULATION OF PROTEIN MODIFICATION PROCESS | 9 | 1710 | 0.0001379 | 0.005217 |
124 | PATTERN SPECIFICATION PROCESS | 5 | 418 | 0.0001465 | 0.005496 |
125 | POSITIVE REGULATION OF OSSIFICATION | 3 | 84 | 0.0001538 | 0.005724 |
126 | CELL DEATH | 7 | 1001 | 0.0001673 | 0.006178 |
127 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 7 | 1004 | 0.0001704 | 0.006244 |
128 | POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 4 | 228 | 0.0001724 | 0.006267 |
129 | MORPHOGENESIS OF AN ENDOTHELIUM | 2 | 16 | 0.0001781 | 0.006424 |
130 | POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 5 | 437 | 0.0001802 | 0.00645 |
131 | SEGMENTATION | 3 | 89 | 0.0001825 | 0.006483 |
132 | POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT | 4 | 232 | 0.0001843 | 0.006496 |
133 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 8 | 1381 | 0.0001893 | 0.006624 |
134 | REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 2 | 17 | 0.0002017 | 0.007003 |
135 | EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS | 3 | 93 | 0.0002079 | 0.007112 |
136 | SENSORY ORGAN MORPHOGENESIS | 4 | 239 | 0.0002065 | 0.007112 |
137 | NEUROGENESIS | 8 | 1402 | 0.0002102 | 0.007138 |
138 | CELLULAR RESPONSE TO LIPID | 5 | 457 | 0.0002219 | 0.007481 |
139 | SIGNAL TRANSDUCTION INVOLVED IN REGULATION OF GENE EXPRESSION | 2 | 18 | 0.0002267 | 0.007589 |
140 | CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND | 5 | 465 | 0.0002404 | 0.007991 |
141 | COGNITION | 4 | 251 | 0.000249 | 0.008126 |
142 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 9 | 1848 | 0.0002497 | 0.008126 |
143 | REGULATION OF MITOTIC CELL CYCLE | 5 | 468 | 0.0002477 | 0.008126 |
144 | WOUND HEALING | 5 | 470 | 0.0002526 | 0.008164 |
145 | REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION | 3 | 100 | 0.0002575 | 0.008264 |
146 | REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 6 | 750 | 0.0002619 | 0.008348 |
147 | LEUKOCYTE CELL CELL ADHESION | 4 | 255 | 0.0002644 | 0.00837 |
148 | TONGUE DEVELOPMENT | 2 | 20 | 0.0002811 | 0.008662 |
149 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 7 | 1087 | 0.0002782 | 0.008662 |
150 | REGULATION OF SULFUR METABOLIC PROCESS | 2 | 20 | 0.0002811 | 0.008662 |
151 | NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION | 2 | 20 | 0.0002811 | 0.008662 |
152 | CELL CELL SIGNALING | 6 | 767 | 0.0002956 | 0.009048 |
153 | REGULATION OF FAT CELL DIFFERENTIATION | 3 | 106 | 0.0003057 | 0.009298 |
154 | MRNA TRANSCRIPTION | 2 | 21 | 0.0003105 | 0.00932 |
155 | COCHLEA MORPHOGENESIS | 2 | 21 | 0.0003105 | 0.00932 |
156 | RESPONSE TO RETINOIC ACID | 3 | 107 | 0.0003143 | 0.009374 |
157 | NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS | 3 | 109 | 0.0003319 | 0.009836 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | BETA CATENIN BINDING | 7 | 84 | 8.076e-12 | 7.503e-09 |
2 | KINASE BINDING | 10 | 606 | 1.314e-09 | 6.104e-07 |
3 | FRIZZLED BINDING | 4 | 36 | 1.088e-07 | 3.37e-05 |
4 | ENZYME BINDING | 12 | 1737 | 3.154e-07 | 7.326e-05 |
5 | TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING | 7 | 588 | 5.553e-06 | 0.001032 |
6 | RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING | 4 | 104 | 8.024e-06 | 0.001242 |
7 | RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING | 3 | 36 | 1.199e-05 | 0.001591 |
8 | ANDROGEN RECEPTOR BINDING | 3 | 39 | 1.531e-05 | 0.001777 |
9 | TRANSCRIPTION COACTIVATOR ACTIVITY | 5 | 296 | 2.861e-05 | 0.002953 |
10 | TRANSCRIPTION FACTOR BINDING | 6 | 524 | 3.642e-05 | 0.003383 |
11 | RECEPTOR BINDING | 9 | 1476 | 4.373e-05 | 0.003693 |
12 | ACTIVATING TRANSCRIPTION FACTOR BINDING | 3 | 57 | 4.828e-05 | 0.003738 |
13 | HORMONE RECEPTOR BINDING | 4 | 168 | 5.294e-05 | 0.003784 |
14 | SMAD BINDING | 3 | 72 | 9.72e-05 | 0.006085 |
15 | CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY | 2 | 12 | 9.825e-05 | 0.006085 |
16 | RHO GTPASE BINDING | 3 | 78 | 0.0001234 | 0.007164 |
17 | STEROID HORMONE RECEPTOR BINDING | 3 | 81 | 0.000138 | 0.007543 |
18 | PROTEIN KINASE C ACTIVITY | 2 | 16 | 0.0001781 | 0.009191 |
19 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 5 | 445 | 0.0001961 | 0.009587 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | WNT SIGNALOSOME | 3 | 11 | 2.828e-07 | 0.0001652 |
2 | CHROMOSOME | 9 | 880 | 6.414e-07 | 0.0001873 |
3 | CHROMATIN | 6 | 441 | 1.378e-05 | 0.002285 |
4 | DENDRITE | 6 | 451 | 1.565e-05 | 0.002285 |
5 | NUCLEAR CHROMATIN | 5 | 291 | 2.636e-05 | 0.002375 |
6 | TRANSCRIPTION FACTOR COMPLEX | 5 | 298 | 2.954e-05 | 0.002375 |
7 | LATERAL PLASMA MEMBRANE | 3 | 50 | 3.253e-05 | 0.002375 |
8 | SYNAPSE | 7 | 754 | 2.792e-05 | 0.002375 |
9 | SYNAPSE PART | 6 | 610 | 8.476e-05 | 0.0055 |
10 | EXCITATORY SYNAPSE | 4 | 197 | 9.821e-05 | 0.005736 |
11 | SOMATODENDRITIC COMPARTMENT | 6 | 650 | 0.0001202 | 0.006383 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | hsa04310_Wnt_signaling_pathway | 25 | 387 | 6.754e-44 | 1.195e-41 | |
2 | hsa04916_Melanogenesis | 13 | 387 | 1.84e-16 | 1.628e-14 | |
3 | hsa04720_Long.term_potentiation | 7 | 387 | 3.424e-07 | 2.02e-05 | |
4 | hsa04020_Calcium_signaling_pathway | 6 | 387 | 6.549e-06 | 0.0002898 | |
5 | hsa04114_Oocyte_meiosis | 5 | 387 | 0.0001021 | 0.003011 | |
6 | hsa04971_Gastric_acid_secretion | 5 | 387 | 0.0001021 | 0.003011 | |
7 | hsa04012_ErbB_signaling_pathway | 4 | 387 | 0.001265 | 0.01493 | |
8 | hsa04330_Notch_signaling_pathway | 4 | 387 | 0.001265 | 0.01493 | |
9 | hsa04370_VEGF_signaling_pathway | 4 | 387 | 0.001265 | 0.01493 | |
10 | hsa04510_Focal_adhesion | 4 | 387 | 0.001265 | 0.01493 | |
11 | hsa04520_Adherens_junction | 4 | 387 | 0.001265 | 0.01493 | |
12 | hsa04530_Tight_junction | 4 | 387 | 0.001265 | 0.01493 | |
13 | hsa04650_Natural_killer_cell_mediated_cytotoxicity | 4 | 387 | 0.001265 | 0.01493 | |
14 | hsa04730_Long.term_depression | 4 | 387 | 0.001265 | 0.01493 | |
15 | hsa04912_GnRH_signaling_pathway | 4 | 387 | 0.001265 | 0.01493 | |
16 | hsa04010_MAPK_signaling_pathway | 3 | 387 | 0.01206 | 0.08208 | |
17 | hsa04070_Phosphatidylinositol_signaling_system | 3 | 387 | 0.01206 | 0.08208 | |
18 | hsa04110_Cell_cycle | 3 | 387 | 0.01206 | 0.08208 | |
19 | hsa04270_Vascular_smooth_muscle_contraction | 3 | 387 | 0.01206 | 0.08208 | |
20 | hsa04350_TGF.beta_signaling_pathway | 3 | 387 | 0.01206 | 0.08208 | |
21 | hsa04540_Gap_junction | 3 | 387 | 0.01206 | 0.08208 | |
22 | hsa04662_B_cell_receptor_signaling_pathway | 3 | 387 | 0.01206 | 0.08208 | |
23 | hsa04670_Leukocyte_transendothelial_migration | 3 | 387 | 0.01206 | 0.08208 | |
24 | hsa04722_Neurotrophin_signaling_pathway | 3 | 387 | 0.01206 | 0.08208 | |
25 | hsa04970_Salivary_secretion | 3 | 387 | 0.01206 | 0.08208 | |
26 | hsa04972_Pancreatic_secretion | 3 | 387 | 0.01206 | 0.08208 | |
27 | hsa03015_mRNA_surveillance_pathway | 2 | 387 | 0.08369 | 0.4251 | |
28 | hsa04062_Chemokine_signaling_pathway | 2 | 387 | 0.08369 | 0.4251 | |
29 | hsa04340_Hedgehog_signaling_pathway | 2 | 387 | 0.08369 | 0.4251 | |
30 | hsa04360_Axon_guidance | 2 | 387 | 0.08369 | 0.4251 | |
31 | hsa04630_Jak.STAT_signaling_pathway | 2 | 387 | 0.08369 | 0.4251 | |
32 | hsa04660_T_cell_receptor_signaling_pathway | 2 | 387 | 0.08369 | 0.4251 | |
33 | hsa04666_Fc_gamma_R.mediated_phagocytosis | 2 | 387 | 0.08369 | 0.4251 | |
34 | hsa04960_Aldosterone.regulated_sodium_reabsorption | 2 | 387 | 0.08369 | 0.4251 | |
35 | hsa04740_Olfactory_transduction | 2 | 388 | 0.08406 | 0.4251 |