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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7b-5p CCND3 0.14 0.15257 -1.83 0.02652 miRNAWalker2 validate -1.84 0.00329
2 hsa-miR-10a-5p DVL1 0.05 0.70373 0 0 miRNAWalker2 validate -0.1 0.02959
3 hsa-miR-155-5p PSEN1 0.44 0.06086 -2.36 0.01393 miRNAWalker2 validate -0.59 0.03354
4 hsa-miR-155-5p SMAD3 0.44 0.06086 -1.06 0.0964 miRNAWalker2 validate -0.52 0.04683
5 hsa-miR-16-5p CAMK2G 0.11 0.25452 -1.61 0.13617 miRNAWalker2 validate -1.12 0.04008
6 hsa-miR-16-5p CCND3 0.11 0.25452 -1.83 0.02652 miRNAWalker2 validate; miRTarBase; miRNATAP -1.81 0.00263
7 hsa-miR-17-5p SMAD3 0.44 0.00967 -1.06 0.0964 miRNAWalker2 validate -0.71 0.04882
8 hsa-miR-186-5p CAMK2B 1.11 0.19322 -0.91 0.14436 miRNAWalker2 validate; miRNATAP -0.2 0.04684
9 hsa-miR-194-5p EP300 -0.25 0.16359 0.67 0.2429 miRNAWalker2 validate -0.77 0.04574
10 hsa-miR-21-5p DAAM1 0.23 0.00828 -0.87 0.14392 miRNAWalker2 validate -1.6 0.04408
11 hsa-miR-27b-3p CCND3 0.19 0.12698 -1.83 0.02652 miRNAWalker2 validate -1.26 0.00118
12 hsa-miR-324-5p CCND3 0.58 0.02606 -1.83 0.02652 miRNAWalker2 validate -0.52 0.00177
13 hsa-miR-324-5p VANGL1 0.58 0.02606 -0.33 0.82527 miRNAWalker2 validate -0.18 0.01236
14 hsa-miR-34a-5p CCND3 0.19 0.17145 -1.83 0.02652 miRNAWalker2 validate -0.95 0.00801
15 hsa-miR-34a-5p CTNNB1 0.19 0.17145 0 0 miRNAWalker2 validate -0.16 0.04451
16 hsa-miR-361-3p NFATC3 0.44 0.31285 -0.06 0.94841 miRNAWalker2 validate -0.07 0.04129
17 hsa-miR-424-5p CCND3 0.62 0.00401 -1.83 0.02652 miRNAWalker2 validate; miRTarBase -0.61 0.00184
18 hsa-miR-98-5p VANGL1 0.53 0.01502 -0.33 0.82527 miRNAWalker2 validate -0.18 0.03777
19 hsa-miR-98-5p WNT10B 0.53 0.01502 -1.49 0.00278 miRNAWalker2 validate -0.77 0.03993
20 hsa-let-7b-3p DAAM1 0.68 0.01987 -0.87 0.14392 MirTarget -0.37 0.03873
21 hsa-let-7f-1-3p DAAM1 0.66 0.00733 -0.87 0.14392 MirTarget -0.42 0.04933
22 hsa-miR-1224-5p PSEN1 0.33 0.07543 -2.36 0.01393 MirTarget -0.79 0.02807
23 hsa-miR-1225-3p CCND3 0.19 0.05199 -1.83 0.02652 MirTarget -1.46 0.01737
24 hsa-miR-130b-3p DAAM1 0.73 0.00544 -0.87 0.14392 MirTarget; miRNATAP -0.42 0.03451
25 hsa-miR-140-5p PSEN1 0.33 0.06517 -2.36 0.01393 MirTarget; miRanda -0.97 0.00604
26 hsa-miR-145-5p SMAD3 0.59 0.13573 -1.06 0.0964 MirTarget; miRNATAP -0.35 0.01824
27 hsa-miR-145-5p PPP3R2 0.59 0.13573 -0.49 0.53667 MirTarget -0.28 0.03715
28 hsa-miR-195-5p NFATC3 -0.07 0.70188 -0.06 0.94841 MirTarget; miRNATAP -0.25 0.00847
29 hsa-miR-197-3p PPP2R5A 0.32 0.06134 -0.42 0.68036 MirTarget -0.44 0.00884
30 hsa-miR-21-3p PSEN1 0.68 0.00116 -2.36 0.01393 MirTarget -0.68 0.01616
31 hsa-miR-214-3p PSEN1 0.81 0.00444 -2.36 0.01393 MirTarget -0.54 0.00847
32 hsa-miR-214-3p PPP2CB 0.81 0.00444 -0.96 0.13485 MirTarget -0.51 0.00868
33 hsa-miR-24-3p CAMK2B 0.28 0.01927 -0.91 0.14436 MirTarget -2.01 0.00784
34 hsa-miR-32-3p PPP2CB 0.5 0.02563 -0.96 0.13485 MirTarget -0.64 0.01606
35 hsa-miR-324-5p PRKCG 0.58 0.02606 -1.63 0.17124 MirTarget; PITA; miRanda; miRNATAP -1.02 0.04462
36 hsa-miR-335-3p PSEN1 0.85 0.00062 -2.36 0.01393 MirTarget -0.58 0.012
37 hsa-miR-361-3p CAMK2B 0.44 0.31285 -0.91 0.14436 MirTarget; miRNATAP -0.47 0.01257
38 hsa-miR-497-5p NFATC3 -0.03 0.91972 -0.06 0.94841 MirTarget; miRNATAP -0.14 0.0127
39 hsa-miR-634 DAAM1 0.59 0.05166 -0.87 0.14392 MirTarget -0.43 0.01174
40 hsa-miR-634 CAMK2G 0.59 0.05166 -1.61 0.13617 MirTarget; PITA; miRNATAP -0.32 0.01115
41 hsa-miR-7-5p PRKCB 0.82 0.00417 -0.48 0.14744 MirTarget; miRNATAP -0.29 0.04774
42 hsa-miR-940 CCND3 0.17 0.08339 -1.83 0.02652 MirTarget; miRNATAP -1.72 0.00443
43 hsa-miR-940 CAMK2B 0.17 0.08339 -0.91 0.14436 PITA; miRNATAP -2.49 0.02741
44 hsa-miR-188-5p WNT10B 0.44 0.01154 -1.49 0.00278 PITA -1.21 0.00985
45 hsa-miR-940 TBL1Y 0.17 0.08339 -1.26 0.04879 PITA -1.52 0.0302
46 hsa-miR-17-5p PSEN1 0.44 0.00967 -2.36 0.01393 TargetScan -0.88 0.02046
47 hsa-miR-17-5p VANGL1 0.44 0.00967 -0.33 0.82527 TargetScan; miRNATAP -0.26 0.02092
48 hsa-miR-107 PSEN1 0.21 0.08342 -2.36 0.01393 miRanda -1.67 0.00394
49 hsa-miR-199b-5p CAMK2B 0.61 0.02975 -0.91 0.14436 miRanda -0.73 0.0112
50 hsa-miR-320a CCND3 0.13 0.34701 -1.83 0.02652 miRanda -1.1 0.00267
51 hsa-miR-320a PSEN1 0.13 0.34701 -2.36 0.01393 miRanda; mirMAP -1.06 0.04426
52 hsa-miR-361-5p PPP2CB 0.45 0.0617 -0.96 0.13485 miRanda -0.5 0.04519
53 hsa-miR-361-5p PSEN1 0.45 0.0617 -2.36 0.01393 miRanda -0.66 0.01085
54 hsa-miR-429 PLCB4 -0.09 0.68169 1.59 0.12874 miRanda -0.74 0.03555
55 hsa-miR-590-5p SOX17 0.14 0.54667 0.7 0.51439 miRanda -0.14 0.03712
56 hsa-miR-1237-3p CAMK2B 0.52 0.00934 -0.91 0.14436 mirMAP -1.2 0.00226
57 hsa-miR-150-5p CAMK2B 0.26 0.33481 -0.91 0.14436 mirMAP -0.75 0.01815
58 hsa-miR-34a-5p CAMK2B 0.19 0.17145 -0.91 0.14436 mirMAP -1.62 0.01313
59 hsa-let-7b-3p PSEN1 0.68 0.01987 -2.36 0.01393 mirMAP -0.48 0.02272
60 hsa-let-7f-1-3p PSEN1 0.66 0.00733 -2.36 0.01393 mirMAP -0.63 0.00902
61 hsa-miR-1237-3p PSEN1 0.52 0.00934 -2.36 0.01393 mirMAP -0.68 0.03
62 hsa-miR-136-5p PSEN1 0.45 0.08353 -2.36 0.01393 mirMAP -0.62 0.01014
63 hsa-miR-197-3p PSEN1 0.32 0.06134 -2.36 0.01393 mirMAP -0.85 0.0322
64 hsa-miR-29b-1-5p PSEN1 0.79 0.00532 -2.36 0.01393 mirMAP -0.52 0.01303
65 hsa-miR-32-3p PSEN1 0.5 0.02563 -2.36 0.01393 mirMAP -0.64 0.02304
66 hsa-miR-548c-5p PSEN1 0.37 0.09194 -2.36 0.01393 mirMAP -0.67 0.02249
67 hsa-miR-548d-5p PSEN1 0.23 0.18403 -2.36 0.01393 mirMAP -0.92 0.01975
68 hsa-miR-32-3p DAAM1 0.5 0.02563 -0.87 0.14392 mirMAP -0.52 0.03036
69 hsa-miR-324-3p PPARD 0.45 0.05568 -0.74 0.27453 mirMAP -0.68 0.0405
70 hsa-miR-625-3p PPARD 0.71 0.00052 -0.74 0.27453 mirMAP -0.75 0.03708
71 hsa-miR-1228-3p WNT9A 0.12 0.13978 -1.66 0.03538 mirMAP -5.09 0.04774
72 hsa-miR-186-5p TCF7L2 1.11 0.19322 -1.35 0.12977 mirMAP -0.13 0.03029
73 hsa-miR-590-5p DVL3 0.14 0.54667 0 0 mirMAP -0.31 0.00237
74 hsa-miR-1237-3p PRKCB 0.52 0.00934 -0.48 0.14744 mirMAP -0.53 0.01103
75 hsa-miR-29b-1-5p PRKCB 0.79 0.00532 -0.48 0.14744 mirMAP -0.3 0.03959
76 hsa-miR-1237-3p SMAD3 0.52 0.00934 -1.06 0.0964 mirMAP -0.78 0.00621
77 hsa-miR-186-5p SMAD3 1.11 0.19322 -1.06 0.0964 mirMAP -0.16 0.01706
78 hsa-miR-32-3p SMAD3 0.5 0.02563 -1.06 0.0964 mirMAP -0.7 0.00676
79 hsa-miR-141-3p VANGL1 -0.11 0.50173 -0.33 0.82527 mirMAP -0.28 0.03523
80 hsa-miR-148a-3p VANGL1 0.11 0.41246 -0.33 0.82527 mirMAP -0.46 0.00323
81 hsa-miR-16-5p VANGL1 0.11 0.25452 -0.33 0.82527 mirMAP -0.63 0.01485
82 hsa-miR-19a-3p VANGL1 0.29 0.05074 -0.33 0.82527 mirMAP -0.33 0.01523
83 hsa-miR-19b-3p VANGL1 0.22 0.07368 -0.33 0.82527 mirMAP -0.45 0.00947
84 hsa-miR-200a-3p VANGL1 -0.03 0.87657 -0.33 0.82527 mirMAP -0.29 0.02171
85 hsa-miR-590-5p VANGL1 0.14 0.54667 -0.33 0.82527 mirMAP -0.19 0.03273
86 hsa-miR-30b-5p PPP3R2 0.14 0.41338 -0.49 0.53667 mirMAP -0.67 0.04039
87 hsa-miR-20b-5p VANGL1 0.44 0.01538 -0.33 0.82527 miRNATAP -0.26 0.01136
88 hsa-miR-106b-5p VANGL1 0.29 0.0333 -0.33 0.82527 miRNATAP -0.39 0.0097
89 hsa-miR-93-5p VANGL1 0.52 0.00425 -0.33 0.82527 miRNATAP -0.24 0.02304
90 hsa-miR-29b-3p CAMK2G 0.2 0.12015 -1.61 0.13617 miRNATAP -0.78 0.03009
91 hsa-miR-324-3p FZD9 0.45 0.05568 -1.47 0.00832 miRNATAP -0.76 0.03309
92 hsa-miR-150-5p PPP2CB 0.26 0.33481 -0.96 0.13485 miRNATAP -0.63 0.00458
93 hsa-miR-20a-5p VANGL1 0.29 0.03283 -0.33 0.82527 miRNATAP -0.39 0.00993
94 hsa-miR-429 VANGL1 -0.09 0.68169 -0.33 0.82527 miRNATAP -0.2 0.02998
95 hsa-miR-10b-5p CAMK2B -0.1 0.56684 -0.91 0.14436 miRNATAP -1.23 0.01915
96 hsa-miR-15b-5p CCND3 0.16 0.15019 -1.83 0.02652 miRNATAP -1.42 0.00467
97 hsa-miR-27a-3p PSEN1 0.25 0.02787 -2.36 0.01393 miRNATAP -1.87 0.00173
98 hsa-miR-28-5p CCND3 0.14 0.34859 -1.83 0.02652 miRNATAP -0.99 0.00342
99 hsa-miR-92a-3p DAAM1 0.45 0.00539 -0.87 0.14392 miRNATAP -0.79 0.01613
100 hsa-miR-29a-3p CAMK2G 0.18 0.10677 -1.61 0.13617 miRNATAP -0.95 0.02221
101 hsa-miR-15a-5p CCND3 0.14 0.21128 -1.83 0.02652 miRNATAP -1.55 0.00152
102 hsa-miR-107 CAMK2G 0.21 0.08342 -1.61 0.13617 miRNATAP -0.76 0.04418
103 hsa-miR-574-5p CAMK2B 0.31 0.04403 -0.91 0.14436 miRNATAP -1.29 0.02435
104 hsa-miR-27b-3p PSEN1 0.19 0.12698 -2.36 0.01393 miRNATAP -1.43 0.00951
NumGOOverlapSizeP ValueAdj. P Value
1 CANONICAL WNT SIGNALING PATHWAY 9 95 1.602e-15 7.453e-12
2 WNT SIGNALING PATHWAY 11 351 1.49e-13 3.466e-10
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 15 1672 9.364e-11 1.452e-07
4 NON CANONICAL WNT SIGNALING PATHWAY 7 140 3.064e-10 3.564e-07
5 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 8.246e-10 7.674e-07
6 POSITIVE REGULATION OF CELL DIFFERENTIATION 11 823 1.409e-09 1.092e-06
7 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 12 1142 2.95e-09 1.961e-06
8 PROTEIN STABILIZATION 6 131 1.125e-08 6.545e-06
9 EMBRYONIC ORGAN MORPHOGENESIS 7 279 3.697e-08 1.912e-05
10 HEART DEVELOPMENT 8 466 6.247e-08 2.907e-05
11 LYMPHOCYTE ACTIVATION 7 342 1.483e-07 5.757e-05
12 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 9 740 1.485e-07 5.757e-05
13 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 8 554 2.352e-07 7.358e-05
14 REGULATION OF PROTEIN STABILITY 6 221 2.527e-07 7.358e-05
15 CARDIOVASCULAR SYSTEM DEVELOPMENT 9 788 2.53e-07 7.358e-05
16 CIRCULATORY SYSTEM DEVELOPMENT 9 788 2.53e-07 7.358e-05
17 CELL ACTIVATION 8 568 2.844e-07 7.533e-05
18 POSITIVE REGULATION OF GENE EXPRESSION 12 1733 3.076e-07 7.533e-05
19 CELL FATE COMMITMENT 6 227 2.959e-07 7.533e-05
20 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 1395 3.27e-07 7.609e-05
21 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 6 236 3.719e-07 8.239e-05
22 ORGAN MORPHOGENESIS 9 841 4.383e-07 8.866e-05
23 REGULATION OF ORGAN MORPHOGENESIS 6 242 4.309e-07 8.866e-05
24 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 12 1805 4.792e-07 8.918e-05
25 EMBRYONIC ORGAN DEVELOPMENT 7 406 4.729e-07 8.918e-05
26 LEUKOCYTE ACTIVATION 7 414 5.392e-07 9.65e-05
27 REGULATION OF CELL DIFFERENTIATION 11 1492 6.429e-07 0.0001108
28 POSITIVE REGULATION OF RESPONSE TO STIMULUS 12 1929 9.833e-07 0.0001634
29 REGULATION OF BINDING 6 283 1.075e-06 0.0001725
30 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 1.297e-06 0.0002012
31 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 1.527e-06 0.0002293
32 SENSORY ORGAN DEVELOPMENT 7 493 1.733e-06 0.000252
33 REGULATION OF WNT SIGNALING PATHWAY 6 310 1.825e-06 0.0002574
34 EMBRYONIC HEART TUBE DEVELOPMENT 4 73 1.949e-06 0.0002592
35 POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 20 1.939e-06 0.0002592
36 TUBE MORPHOGENESIS 6 323 2.315e-06 0.0002993
37 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 3 22 2.616e-06 0.0003289
38 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 2.958e-06 0.0003622
39 EMBRYONIC MORPHOGENESIS 7 539 3.131e-06 0.0003735
40 ANTERIOR POSTERIOR PATTERN SPECIFICATION 5 194 3.701e-06 0.0004089
41 TUBE DEVELOPMENT 7 552 3.664e-06 0.0004089
42 REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 552 3.664e-06 0.0004089
43 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 1784 3.779e-06 0.0004089
44 POSITIVE REGULATION OF MOLECULAR FUNCTION 11 1791 3.927e-06 0.0004152
45 SKELETAL SYSTEM MORPHOGENESIS 5 201 4.401e-06 0.000455
46 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 10 1492 5.984e-06 0.0006053
47 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 10 1517 6.942e-06 0.0006655
48 REGULATION OF PROTEIN CATABOLIC PROCESS 6 393 7.152e-06 0.0006655
49 NEGATIVE REGULATION OF CELL DEATH 8 872 7.055e-06 0.0006655
50 NEGATIVE REGULATION OF CELL DIFFERENTIATION 7 609 6.989e-06 0.0006655
51 POSITIVE REGULATION OF CELL COMMUNICATION 10 1532 7.58e-06 0.0006779
52 REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 103 7.722e-06 0.0006779
53 REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 103 7.722e-06 0.0006779
54 MORPHOGENESIS OF AN EPITHELIUM 6 400 7.911e-06 0.0006816
55 EMBRYO DEVELOPMENT 8 894 8.471e-06 0.0007166
56 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 4 110 1.002e-05 0.0008215
57 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 3 34 1.006e-05 0.0008215
58 REGULATION OF EMBRYONIC DEVELOPMENT 4 114 1.155e-05 0.0009263
59 NEGATIVE REGULATION OF CELL CYCLE 6 433 1.242e-05 0.0009797
60 MYOBLAST DIFFERENTIATION 3 37 1.303e-05 0.0009964
61 CELL PROLIFERATION 7 672 1.328e-05 0.0009964
62 REGULATION OF PROTEIN LOCALIZATION 8 950 1.321e-05 0.0009964
63 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 8 957 1.393e-05 0.001029
64 SKELETAL SYSTEM DEVELOPMENT 6 455 1.645e-05 0.001196
65 CELL CYCLE 9 1316 1.753e-05 0.001255
66 HEPATICOBILIARY SYSTEM DEVELOPMENT 4 128 1.824e-05 0.001286
67 REGULATION OF PROTEOLYSIS 7 711 1.913e-05 0.001328
68 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 43 2.06e-05 0.001389
69 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 2.06e-05 0.001389
70 REGULATION OF CATABOLIC PROCESS 7 731 2.288e-05 0.001499
71 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 9 1360 2.282e-05 0.001499
72 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 8 1036 2.476e-05 0.001578
73 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 8 1036 2.476e-05 0.001578
74 REGULATION OF CHONDROCYTE DIFFERENTIATION 3 46 2.528e-05 0.001589
75 DIGESTIVE TRACT MORPHOGENESIS 3 48 2.875e-05 0.001784
76 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 3 50 3.253e-05 0.001916
77 DIGESTIVE SYSTEM DEVELOPMENT 4 148 3.227e-05 0.001916
78 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 3 50 3.253e-05 0.001916
79 REGULATION OF TRANSPORT 10 1804 3.2e-05 0.001916
80 NEURAL TUBE DEVELOPMENT 4 149 3.313e-05 0.001927
81 CELL CYCLE PROCESS 8 1081 3.362e-05 0.001931
82 REGIONALIZATION 5 311 3.623e-05 0.002056
83 GASTRULATION 4 155 3.867e-05 0.002168
84 TISSUE MORPHOGENESIS 6 533 4.006e-05 0.002219
85 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 7 801 4.111e-05 0.00225
86 REGULATION OF CELL DEATH 9 1472 4.28e-05 0.002316
87 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 4 162 4.595e-05 0.002457
88 NEGATIVE REGULATION OF GENE EXPRESSION 9 1493 4.786e-05 0.002502
89 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 4.766e-05 0.002502
90 REGULATION OF CELL MORPHOGENESIS 6 552 4.87e-05 0.002518
91 REGULATION OF PROTEIN BINDING 4 168 5.294e-05 0.002651
92 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 8 1152 5.298e-05 0.002651
93 RESPONSE TO CARBOHYDRATE 4 168 5.294e-05 0.002651
94 REGULATION OF CELL DEVELOPMENT 7 836 5.397e-05 0.002672
95 TISSUE DEVELOPMENT 9 1518 5.455e-05 0.002672
96 STEM CELL PROLIFERATION 3 60 5.633e-05 0.00273
97 SOMITOGENESIS 3 62 6.215e-05 0.002951
98 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 6.215e-05 0.002951
99 REGULATION OF CARTILAGE DEVELOPMENT 3 63 6.52e-05 0.003011
100 IMMUNE SYSTEM DEVELOPMENT 6 582 6.536e-05 0.003011
101 REGULATION OF MUSCLE ADAPTATION 3 63 6.52e-05 0.003011
102 NEGATIVE REGULATION OF CELL COMMUNICATION 8 1192 6.751e-05 0.00308
103 INTRACELLULAR SIGNAL TRANSDUCTION 9 1572 7.176e-05 0.00318
104 CELLULAR RESPONSE TO RETINOIC ACID 3 65 7.16e-05 0.00318
105 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 4 181 7.074e-05 0.00318
106 IMMUNE SYSTEM PROCESS 10 1984 7.271e-05 0.003192
107 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 365 7.747e-05 0.003369
108 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 3 67 7.84e-05 0.003378
109 ENDODERM DEVELOPMENT 3 71 9.323e-05 0.003944
110 CELL FATE SPECIFICATION 3 71 9.323e-05 0.003944
111 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 4 197 9.821e-05 0.004117
112 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 4 199 0.0001021 0.004243
113 REGULATION OF CELLULAR LOCALIZATION 8 1277 0.0001097 0.004517
114 EPITHELIUM DEVELOPMENT 7 945 0.0001169 0.004647
115 REGULATION OF CELLULAR RESPONSE TO HEAT 3 76 0.0001142 0.004647
116 REGULATION OF SKELETAL MUSCLE ADAPTATION 2 13 0.000116 0.004647
117 ENDODERMAL CELL FATE COMMITMENT 2 13 0.000116 0.004647
118 REGULATION OF CELL CYCLE 7 949 0.00012 0.004731
119 SOMITE DEVELOPMENT 3 78 0.0001234 0.004824
120 HEART MORPHOGENESIS 4 212 0.0001304 0.005054
121 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 2 14 0.0001353 0.005159
122 EMBRYONIC SKELETAL JOINT DEVELOPMENT 2 14 0.0001353 0.005159
123 REGULATION OF PROTEIN MODIFICATION PROCESS 9 1710 0.0001379 0.005217
124 PATTERN SPECIFICATION PROCESS 5 418 0.0001465 0.005496
125 POSITIVE REGULATION OF OSSIFICATION 3 84 0.0001538 0.005724
126 CELL DEATH 7 1001 0.0001673 0.006178
127 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 7 1004 0.0001704 0.006244
128 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 4 228 0.0001724 0.006267
129 MORPHOGENESIS OF AN ENDOTHELIUM 2 16 0.0001781 0.006424
130 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 5 437 0.0001802 0.00645
131 SEGMENTATION 3 89 0.0001825 0.006483
132 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.0001843 0.006496
133 RESPONSE TO OXYGEN CONTAINING COMPOUND 8 1381 0.0001893 0.006624
134 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 2 17 0.0002017 0.007003
135 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 3 93 0.0002079 0.007112
136 SENSORY ORGAN MORPHOGENESIS 4 239 0.0002065 0.007112
137 NEUROGENESIS 8 1402 0.0002102 0.007138
138 CELLULAR RESPONSE TO LIPID 5 457 0.0002219 0.007481
139 SIGNAL TRANSDUCTION INVOLVED IN REGULATION OF GENE EXPRESSION 2 18 0.0002267 0.007589
140 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 5 465 0.0002404 0.007991
141 COGNITION 4 251 0.000249 0.008126
142 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 9 1848 0.0002497 0.008126
143 REGULATION OF MITOTIC CELL CYCLE 5 468 0.0002477 0.008126
144 WOUND HEALING 5 470 0.0002526 0.008164
145 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 100 0.0002575 0.008264
146 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 750 0.0002619 0.008348
147 LEUKOCYTE CELL CELL ADHESION 4 255 0.0002644 0.00837
148 TONGUE DEVELOPMENT 2 20 0.0002811 0.008662
149 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 7 1087 0.0002782 0.008662
150 REGULATION OF SULFUR METABOLIC PROCESS 2 20 0.0002811 0.008662
151 NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 2 20 0.0002811 0.008662
152 CELL CELL SIGNALING 6 767 0.0002956 0.009048
153 REGULATION OF FAT CELL DIFFERENTIATION 3 106 0.0003057 0.009298
154 MRNA TRANSCRIPTION 2 21 0.0003105 0.00932
155 COCHLEA MORPHOGENESIS 2 21 0.0003105 0.00932
156 RESPONSE TO RETINOIC ACID 3 107 0.0003143 0.009374
157 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 3 109 0.0003319 0.009836
NumGOOverlapSizeP ValueAdj. P Value
1 BETA CATENIN BINDING 7 84 8.076e-12 7.503e-09
2 KINASE BINDING 10 606 1.314e-09 6.104e-07
3 FRIZZLED BINDING 4 36 1.088e-07 3.37e-05
4 ENZYME BINDING 12 1737 3.154e-07 7.326e-05
5 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 7 588 5.553e-06 0.001032
6 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 4 104 8.024e-06 0.001242
7 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 3 36 1.199e-05 0.001591
8 ANDROGEN RECEPTOR BINDING 3 39 1.531e-05 0.001777
9 TRANSCRIPTION COACTIVATOR ACTIVITY 5 296 2.861e-05 0.002953
10 TRANSCRIPTION FACTOR BINDING 6 524 3.642e-05 0.003383
11 RECEPTOR BINDING 9 1476 4.373e-05 0.003693
12 ACTIVATING TRANSCRIPTION FACTOR BINDING 3 57 4.828e-05 0.003738
13 HORMONE RECEPTOR BINDING 4 168 5.294e-05 0.003784
14 SMAD BINDING 3 72 9.72e-05 0.006085
15 CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY 2 12 9.825e-05 0.006085
16 RHO GTPASE BINDING 3 78 0.0001234 0.007164
17 STEROID HORMONE RECEPTOR BINDING 3 81 0.000138 0.007543
18 PROTEIN KINASE C ACTIVITY 2 16 0.0001781 0.009191
19 PROTEIN SERINE THREONINE KINASE ACTIVITY 5 445 0.0001961 0.009587
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALOSOME 3 11 2.828e-07 0.0001652
2 CHROMOSOME 9 880 6.414e-07 0.0001873
3 CHROMATIN 6 441 1.378e-05 0.002285
4 DENDRITE 6 451 1.565e-05 0.002285
5 NUCLEAR CHROMATIN 5 291 2.636e-05 0.002375
6 TRANSCRIPTION FACTOR COMPLEX 5 298 2.954e-05 0.002375
7 LATERAL PLASMA MEMBRANE 3 50 3.253e-05 0.002375
8 SYNAPSE 7 754 2.792e-05 0.002375
9 SYNAPSE PART 6 610 8.476e-05 0.0055
10 EXCITATORY SYNAPSE 4 197 9.821e-05 0.005736
11 SOMATODENDRITIC COMPARTMENT 6 650 0.0001202 0.006383

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 25 387 6.754e-44 1.195e-41
2 hsa04916_Melanogenesis 13 387 1.84e-16 1.628e-14
3 hsa04720_Long.term_potentiation 7 387 3.424e-07 2.02e-05
4 hsa04020_Calcium_signaling_pathway 6 387 6.549e-06 0.0002898
5 hsa04114_Oocyte_meiosis 5 387 0.0001021 0.003011
6 hsa04971_Gastric_acid_secretion 5 387 0.0001021 0.003011
7 hsa04012_ErbB_signaling_pathway 4 387 0.001265 0.01493
8 hsa04330_Notch_signaling_pathway 4 387 0.001265 0.01493
9 hsa04370_VEGF_signaling_pathway 4 387 0.001265 0.01493
10 hsa04510_Focal_adhesion 4 387 0.001265 0.01493
11 hsa04520_Adherens_junction 4 387 0.001265 0.01493
12 hsa04530_Tight_junction 4 387 0.001265 0.01493
13 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 387 0.001265 0.01493
14 hsa04730_Long.term_depression 4 387 0.001265 0.01493
15 hsa04912_GnRH_signaling_pathway 4 387 0.001265 0.01493
16 hsa04010_MAPK_signaling_pathway 3 387 0.01206 0.08208
17 hsa04070_Phosphatidylinositol_signaling_system 3 387 0.01206 0.08208
18 hsa04110_Cell_cycle 3 387 0.01206 0.08208
19 hsa04270_Vascular_smooth_muscle_contraction 3 387 0.01206 0.08208
20 hsa04350_TGF.beta_signaling_pathway 3 387 0.01206 0.08208
21 hsa04540_Gap_junction 3 387 0.01206 0.08208
22 hsa04662_B_cell_receptor_signaling_pathway 3 387 0.01206 0.08208
23 hsa04670_Leukocyte_transendothelial_migration 3 387 0.01206 0.08208
24 hsa04722_Neurotrophin_signaling_pathway 3 387 0.01206 0.08208
25 hsa04970_Salivary_secretion 3 387 0.01206 0.08208
26 hsa04972_Pancreatic_secretion 3 387 0.01206 0.08208
27 hsa03015_mRNA_surveillance_pathway 2 387 0.08369 0.4251
28 hsa04062_Chemokine_signaling_pathway 2 387 0.08369 0.4251
29 hsa04340_Hedgehog_signaling_pathway 2 387 0.08369 0.4251
30 hsa04360_Axon_guidance 2 387 0.08369 0.4251
31 hsa04630_Jak.STAT_signaling_pathway 2 387 0.08369 0.4251
32 hsa04660_T_cell_receptor_signaling_pathway 2 387 0.08369 0.4251
33 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 387 0.08369 0.4251
34 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 387 0.08369 0.4251
35 hsa04740_Olfactory_transduction 2 388 0.08406 0.4251

Quest ID: 83a4fa4ab2ecf1e6d859dfabd2cb0d50