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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p SLC26A6 -0.94 0.0005 2.67 0 MirTarget; PITA; miRanda; miRNATAP -0.42 0 NA
2 hsa-miR-125b-5p SLC26A6 -1.35 0 2.67 0 MirTarget -0.64 0 NA
3 hsa-miR-429 SLC26A6 -1.46 7.0E-5 2.67 0 miRNATAP -0.12 1.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 ION TRANSPORT 22 1262 2.236e-18 1.04e-14
2 ION TRANSMEMBRANE TRANSPORT 19 822 8.2e-18 1.447e-14
3 CHLORIDE TRANSPORT 11 99 9.328e-18 1.447e-14
4 TRANSMEMBRANE TRANSPORT 20 1098 7.729e-17 8.991e-14
5 INORGANIC ANION TRANSPORT 11 128 1.744e-16 1.623e-13
6 INORGANIC ION TRANSMEMBRANE TRANSPORT 16 583 5.394e-16 4.183e-13
7 ANION TRANSPORT 15 507 1.906e-15 1.267e-12
8 ANION TRANSMEMBRANE TRANSPORT 12 251 7.581e-15 4.409e-12
9 CELLULAR HOMEOSTASIS 13 676 4.987e-11 2.578e-08
10 CELLULAR MONOVALENT INORGANIC CATION HOMEOSTASIS 7 96 2.832e-10 1.318e-07
11 MONOVALENT INORGANIC CATION HOMEOSTASIS 7 123 1.633e-09 6.906e-07
12 REGULATION OF TRANSMEMBRANE TRANSPORT 10 426 1.974e-09 7.653e-07
13 MONOVALENT INORGANIC CATION TRANSPORT 10 435 2.413e-09 8.636e-07
14 REGULATION OF ION TRANSPORT 11 592 3.049e-09 1.013e-06
15 CATION TRANSPORT 12 796 5.22e-09 1.518e-06
16 SODIUM ION TRANSPORT 7 144 4.921e-09 1.518e-06
17 REGULATION OF TRANSPORT 16 1804 1.385e-08 3.792e-06
18 HOMEOSTATIC PROCESS 14 1337 2.038e-08 5.268e-06
19 CELLULAR RESPONSE TO CAMP 5 50 2.439e-08 5.974e-06
20 CELLULAR CHEMICAL HOMEOSTASIS 10 570 3.157e-08 7.345e-06
21 METAL ION TRANSPORT 10 582 3.841e-08 8.51e-06
22 SYSTEM PROCESS 15 1785 9.93e-08 2.1e-05
23 CELL VOLUME HOMEOSTASIS 4 28 1.561e-07 3.159e-05
24 CHEMICAL HOMEOSTASIS 11 874 1.659e-07 3.216e-05
25 REGULATION OF CELLULAR PH 5 75 1.926e-07 3.584e-05
26 REGULATION OF ANION TRANSMEMBRANE TRANSPORT 4 30 2.085e-07 3.731e-05
27 REGULATION OF PH 5 89 4.551e-07 7.843e-05
28 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 10 799 7.245e-07 0.0001204
29 RESPONSE TO CAMP 5 104 9.896e-07 0.0001574
30 BICARBONATE TRANSPORT 4 44 1.015e-06 0.0001574
31 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 8 465 1.09e-06 0.0001636
32 TRANSEPITHELIAL TRANSPORT 3 13 1.387e-06 0.0002017
33 REGULATION OF MEMBRANE POTENTIAL 7 343 1.826e-06 0.0002575
34 CELLULAR RESPONSE TO NITROGEN COMPOUND 8 505 2.019e-06 0.0002763
35 REGULATION OF SYSTEM PROCESS 8 507 2.079e-06 0.0002764
36 CIRCULATORY SYSTEM PROCESS 7 366 2.807e-06 0.0003628
37 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 5 131 3.096e-06 0.0003791
38 POSITIVE REGULATION OF TRANSPORT 10 936 3.028e-06 0.0003791
39 DIGESTIVE SYSTEM PROCESS 4 61 3.82e-06 0.0004558
40 POLYOL TRANSPORT 3 18 3.935e-06 0.0004577
41 RESPONSE TO ORGANOPHOSPHORUS 5 139 4.141e-06 0.0004588
42 ORGANIC ANION TRANSPORT 7 387 4.054e-06 0.0004588
43 CELLULAR SODIUM ION HOMEOSTASIS 3 19 4.667e-06 0.000505
44 ION HOMEOSTASIS 8 576 5.339e-06 0.0005646
45 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 10 1008 5.857e-06 0.0006056
46 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 13 1848 7.232e-06 0.0007315
47 RESPONSE TO PURINE CONTAINING COMPOUND 5 158 7.741e-06 0.0007664
48 REGULATION OF SODIUM ION TRANSPORT 4 77 9.711e-06 0.0009414
49 REGULATION OF BLOOD CIRCULATION 6 295 1.108e-05 0.001053
50 RESPONSE TO NITROGEN COMPOUND 9 859 1.229e-05 0.001133
51 INTESTINAL ABSORPTION 3 26 1.242e-05 0.001133
52 FLUID TRANSPORT 3 27 1.395e-05 0.001248
53 REGULATION OF ANATOMICAL STRUCTURE SIZE 7 472 1.479e-05 0.001299
54 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 1395 1.598e-05 0.001377
55 REGULATION OF THE FORCE OF HEART CONTRACTION 3 29 1.739e-05 0.001471
56 SODIUM ION TRANSMEMBRANE TRANSPORT 4 90 1.804e-05 0.001499
57 REGULATION OF METAL ION TRANSPORT 6 325 1.918e-05 0.001548
58 SODIUM ION HOMEOSTASIS 3 30 1.93e-05 0.001548
59 POSITIVE REGULATION OF BLOOD CIRCULATION 4 93 2.054e-05 0.00162
60 CARBOHYDRATE TRANSPORT 4 95 2.234e-05 0.001733
61 RENAL SYSTEM PROCESS 4 102 2.956e-05 0.002255
62 REGULATION OF DIGESTIVE SYSTEM PROCESS 3 35 3.092e-05 0.002321
63 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 4 104 3.191e-05 0.002357
64 REGULATION OF HEART CONTRACTION 5 221 3.901e-05 0.002836
65 RESPONSE TO ABIOTIC STIMULUS 9 1024 4.929e-05 0.003529
66 POSITIVE REGULATION OF ION TRANSPORT 5 236 5.332e-05 0.003759
67 RESPONSE TO OXYGEN CONTAINING COMPOUND 10 1381 8.873e-05 0.006162
68 LIPID LOCALIZATION 5 264 9.059e-05 0.006199
69 DIGESTION 4 137 9.356e-05 0.006309
70 REGULATION OF ANION TRANSPORT 4 138 9.623e-05 0.006397
71 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 0.0001104 0.007238
72 RESPONSE TO ENDOGENOUS STIMULUS 10 1450 0.0001332 0.008611
73 POTASSIUM ION TRANSPORT 4 154 0.000147 0.009226
74 SENSORY PERCEPTION OF MECHANICAL STIMULUS 4 155 0.0001507 0.009226
75 ORGANIC HYDROXY COMPOUND TRANSPORT 4 155 0.0001507 0.009226
76 RESPONSE TO ORGANIC CYCLIC COMPOUND 8 917 0.0001477 0.009226
77 POSITIVE REGULATION OF GUANYLATE CYCLASE ACTIVITY 2 11 0.000162 0.009791
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSMEMBRANE TRANSPORTER ACTIVITY 20 997 1.189e-17 1.105e-14
2 TRANSPORTER ACTIVITY 21 1276 6.663e-17 3.095e-14
3 INORGANIC ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 11 130 2.078e-16 6.435e-14
4 ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 13 293 1.215e-15 2.821e-13
5 ANION CHANNEL ACTIVITY 8 91 2.855e-12 5.305e-10
6 SECONDARY ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 10 233 5.4e-12 8.361e-10
7 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 12 464 1.086e-11 1.441e-09
8 ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 11 356 1.388e-11 1.612e-09
9 GATED CHANNEL ACTIVITY 10 325 1.432e-10 1.479e-08
10 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 11 622 5.101e-09 4.739e-07
11 MONOVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 9 366 9.682e-09 8.177e-07
12 ACTIVE ION TRANSMEMBRANE TRANSPORTER ACTIVITY 7 171 1.623e-08 1.257e-06
13 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 9 527 2.193e-07 1.567e-05
14 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 8 417 4.799e-07 3.185e-05
15 CALMODULIN BINDING 6 179 6.184e-07 3.83e-05
16 VOLTAGE GATED ION CHANNEL ACTIVITY 6 190 8.767e-07 5.09e-05
17 VOLTAGE GATED CHLORIDE CHANNEL ACTIVITY 3 12 1.068e-06 5.839e-05
18 VOLTAGE GATED ANION CHANNEL ACTIVITY 3 17 3.283e-06 0.0001694
19 SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 5 136 3.721e-06 0.0001819
20 ANTIPORTER ACTIVITY 4 74 8.288e-06 0.000385
21 SOLUTE CATION SYMPORTER ACTIVITY 4 99 2.629e-05 0.001163
22 CARBOHYDRATE TRANSPORTER ACTIVITY 3 44 6.19e-05 0.002614
23 SCAFFOLD PROTEIN BINDING 3 45 6.624e-05 0.002676
24 ION ANTIPORTER ACTIVITY 3 47 7.551e-05 0.002923
25 ANION CATION SYMPORTER ACTIVITY 3 53 0.0001083 0.003727
26 LIGAND GATED CHANNEL ACTIVITY 4 142 0.0001075 0.003727
27 SYMPORTER ACTIVITY 4 142 0.0001075 0.003727
28 CATION CHANNEL ACTIVITY 5 298 0.0001598 0.005302
29 ORGANIC ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 4 178 0.000256 0.008201
30 FMN BINDING 2 15 0.000308 0.00894
31 WATER TRANSMEMBRANE TRANSPORTER ACTIVITY 2 15 0.000308 0.00894
32 POLYOL TRANSMEMBRANE TRANSPORTER ACTIVITY 2 15 0.000308 0.00894
33 INTRACELLULAR CALCIUM ACTIVATED CHLORIDE CHANNEL ACTIVITY 2 16 0.0003516 0.009606
34 CHLORIDE CHANNEL REGULATOR ACTIVITY 2 16 0.0003516 0.009606
NumGOOverlapSizeP ValueAdj. P Value
1 PLASMA MEMBRANE REGION 17 929 3.894e-14 2.274e-11
2 MEMBRANE REGION 17 1134 9.882e-13 2.886e-10
3 CHLORIDE CHANNEL COMPLEX 7 50 2.511e-12 4.889e-10
4 APICAL PLASMA MEMBRANE 10 292 5.019e-11 7.328e-09
5 APICAL PART OF CELL 10 361 3.985e-10 4.655e-08
6 BASOLATERAL PLASMA MEMBRANE 8 211 2.476e-09 2.41e-07
7 TRANSPORTER COMPLEX 9 321 3.092e-09 2.58e-07
8 INTRINSIC COMPONENT OF PLASMA MEMBRANE 16 1649 3.799e-09 2.774e-07
9 MEMBRANE PROTEIN COMPLEX 9 1020 4.781e-05 0.003102
10 INTERCALATED DISC 3 51 9.652e-05 0.005254
11 CLUSTER OF ACTIN BASED CELL PROJECTIONS 4 139 9.896e-05 0.005254
12 BRUSH BORDER MEMBRANE 3 55 0.000121 0.005889
13 EARLY ENDOSOME 5 301 0.0001674 0.007521
14 CELL CELL CONTACT ZONE 3 64 0.0001901 0.007931
15 VESICLE MEMBRANE 6 512 0.000236 0.009187

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 4 137 9.356e-05 0.004865
2 Calcium_signaling_pathway_hsa04020 3 182 0.003917 0.1018
3 HIF_1_signaling_pathway_hsa04066 2 100 0.01323 0.2293
4 AMPK_signaling_pathway_hsa04152 2 121 0.01896 0.2321
5 FoxO_signaling_pathway_hsa04068 2 132 0.02231 0.2321
6 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.03295 0.2643
7 Tight_junction_hsa04530 2 170 0.03558 0.2643
8 cAMP_signaling_pathway_hsa04024 2 198 0.04687 0.3046
9 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.08491 0.4415
10 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.1259 0.4962

Quest ID: 83e76664324c9d251b3dbae8d74f7e26