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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-484 ACTA2 -0.97 0 1.38 0 miRNAWalker2 validate -0.49 0 NA
2 hsa-miR-484 ADAM10 -0.97 0 0.28 0.07197 miRNAWalker2 validate -0.38 0 NA
3 hsa-miR-484 ADAM33 -0.97 0 0.92 0 MirTarget -0.28 6.0E-5 NA
4 hsa-miR-484 ADAMTS15 -0.97 0 1.31 0 mirMAP -0.55 0 NA
5 hsa-miR-484 ADD2 -0.97 0 -0.23 0.38613 miRNATAP -0.37 0.00011 NA
6 hsa-miR-484 ADRA1A -0.97 0 2.36 0 miRNAWalker2 validate -0.98 0 NA
7 hsa-miR-484 AEBP2 -0.97 0 0.32 0 miRNAWalker2 validate -0.13 0 NA
8 hsa-miR-484 AGL -0.97 0 0.51 0 miRNAWalker2 validate -0.27 0 NA
9 hsa-miR-484 AHDC1 -0.97 0 0.63 0 miRNAWalker2 validate -0.12 7.0E-5 NA
10 hsa-miR-484 AKAP13 -0.97 0 0.24 0.00396 miRNAWalker2 validate -0.11 0.00011 NA
11 hsa-miR-484 AKAP7 -0.97 0 0.66 1.0E-5 miRNAWalker2 validate -0.38 0 NA
12 hsa-miR-484 ALDH1L1 -0.97 0 0.7 0.00416 miRNATAP -0.48 0 NA
13 hsa-miR-484 AMOTL1 -0.97 0 0.38 0.00203 miRNAWalker2 validate; MirTarget -0.21 0 NA
14 hsa-miR-484 ANAPC1 -0.97 0 0.1 0.28593 miRNAWalker2 validate -0.17 0 NA
15 hsa-miR-484 ANKFY1 -0.97 0 0.17 0.00776 mirMAP -0.15 0 NA
16 hsa-miR-484 AP1G1 -0.97 0 0.1 0.21459 miRNAWalker2 validate; PITA; miRNATAP -0.13 0 NA
17 hsa-miR-484 APOOL -0.97 0 0.43 0.01073 MirTarget -0.32 0 NA
18 hsa-miR-484 APP -0.97 0 0.48 2.0E-5 miRNAWalker2 validate -0.18 2.0E-5 NA
19 hsa-miR-484 ARFGEF2 -0.97 0 0.32 0.00076 miRNAWalker2 validate -0.21 0 NA
20 hsa-miR-484 ARHGAP5 -0.97 0 0.4 0 miRNATAP -0.18 0 NA
21 hsa-miR-484 ARNT2 -0.97 0 -0.12 0.24902 mirMAP -0.17 1.0E-5 NA
22 hsa-miR-484 ATL2 -0.97 0 0.4 0 miRNAWalker2 validate -0.15 0 NA
23 hsa-miR-484 ATP1A1 -0.97 0 0.26 0.00124 miRNAWalker2 validate -0.11 0.00033 NA
24 hsa-miR-484 ATP1B2 -0.97 0 0.99 0 miRNATAP -0.31 0 NA
25 hsa-miR-484 ATP2A2 -0.97 0 0.33 5.0E-5 miRNAWalker2 validate; mirMAP -0.17 0 NA
26 hsa-miR-484 ATRN -0.97 0 0.01 0.84372 MirTarget; miRNATAP -0.1 1.0E-5 NA
27 hsa-miR-484 ATXN1L -0.97 0 0.43 0 mirMAP -0.21 0 NA
28 hsa-miR-484 AVL9 -0.97 0 -0.23 0.04984 MirTarget; miRNATAP -0.13 0.002 NA
29 hsa-miR-484 B3GALT5 -0.97 0 1.04 0.00017 miRNATAP -0.69 0 NA
30 hsa-miR-484 B3GNT9 -0.97 0 1.28 0 MirTarget -0.34 0 NA
31 hsa-miR-484 B4GALT1 -0.97 0 0.33 3.0E-5 miRNAWalker2 validate -0.2 0 NA
32 hsa-miR-484 BACE2 -0.97 0 -0.38 0.00565 miRNAWalker2 validate -0.17 0.00087 NA
33 hsa-miR-484 BBX -0.97 0 0.86 0 miRNAWalker2 validate -0.26 0 NA
34 hsa-miR-484 BCL11A -0.97 0 1.44 0 PITA -0.63 0 NA
35 hsa-miR-484 BDKRB2 -0.97 0 1.01 0 mirMAP -0.23 0.00036 NA
36 hsa-miR-484 BRWD3 -0.97 0 0.14 0.34526 MirTarget -0.13 0.00994 NA
37 hsa-miR-484 C1orf106 -0.97 0 1.86 0 mirMAP -0.62 0 NA
38 hsa-miR-484 C9orf24 -0.97 0 1.39 0 miRNATAP -0.32 0.00017 NA
39 hsa-miR-484 CACHD1 -0.97 0 1.51 0 miRNATAP -0.6 0 NA
40 hsa-miR-484 CACNA1C -0.97 0 0.77 0 PITA; miRNATAP -0.41 0 NA
41 hsa-miR-484 CALD1 -0.97 0 1.23 0 PITA -0.44 0 NA
42 hsa-miR-484 CALM1 -0.97 0 0.78 0 miRNATAP -0.12 1.0E-5 NA
43 hsa-miR-484 CALN1 -0.97 0 1.52 0 mirMAP -0.56 0 NA
44 hsa-miR-484 CAMK2D -0.97 0 0.51 0 miRNAWalker2 validate -0.1 0.00133 NA
45 hsa-miR-484 CAMK2G -0.97 0 0.89 0 mirMAP -0.26 0 NA
46 hsa-miR-484 CAND1 -0.97 0 0.05 0.46005 mirMAP -0.1 2.0E-5 NA
47 hsa-miR-484 CAPN6 -0.97 0 2.48 0 miRNATAP -0.95 0 NA
48 hsa-miR-484 CBL -0.97 0 0.31 0.00068 miRNATAP -0.11 0.00065 NA
49 hsa-miR-484 CBX6 -0.97 0 0.85 0 miRNAWalker2 validate; mirMAP -0.4 0 NA
50 hsa-miR-484 CCDC136 -0.97 0 0.86 0 miRNAWalker2 validate -0.29 0 NA
51 hsa-miR-484 CCDC60 -0.97 0 1.59 0 miRNATAP -0.85 0 NA
52 hsa-miR-484 CCDC69 -0.97 0 1.37 0 mirMAP -0.48 0 NA
53 hsa-miR-484 CCKBR -0.97 0 1.44 0 miRNATAP -0.55 0 NA
54 hsa-miR-484 CCNT2 -0.97 0 0.22 0.01103 miRNAWalker2 validate -0.1 0.00104 NA
55 hsa-miR-484 CD40 -0.97 0 1.29 0 miRNATAP -0.39 0 NA
56 hsa-miR-484 CD40LG -0.97 0 -0.09 0.7069 miRNATAP -0.28 0.00065 NA
57 hsa-miR-484 CDCA7L -0.97 0 0.54 0.0004 miRNAWalker2 validate -0.21 0.00011 NA
58 hsa-miR-484 CDH23 -0.97 0 1.61 0 mirMAP -0.51 0 NA
59 hsa-miR-484 CDX2 -0.97 0 -0.26 0.4968 miRNAWalker2 validate; PITA -0.37 0.00726 NA
60 hsa-miR-484 CECR2 -0.97 0 -1.22 0 miRNAWalker2 validate -0.24 0.00172 NA
61 hsa-miR-484 CECR6 -0.97 0 -0.45 0.01705 miRNATAP -0.32 0 NA
62 hsa-miR-484 CELF2 -0.97 0 1.12 0 mirMAP -0.45 0 NA
63 hsa-miR-484 CELSR2 -0.97 0 0.97 0 PITA; miRNATAP -0.25 0 NA
64 hsa-miR-484 CHD5 -0.97 0 1.51 0 mirMAP -0.36 0 NA
65 hsa-miR-484 CHST11 -0.97 0 1.23 0 miRNATAP -0.25 0 NA
66 hsa-miR-484 CHST3 -0.97 0 1.2 0 mirMAP -0.41 0 NA
67 hsa-miR-484 CLOCK -0.97 0 0.61 0.00038 MirTarget -0.36 0 NA
68 hsa-miR-484 CNNM1 -0.97 0 -0.37 0.0135 miRNATAP -0.19 0.00047 NA
69 hsa-miR-484 CNTFR -0.97 0 2.23 0 PITA; miRNATAP -0.53 0 NA
70 hsa-miR-484 CNTN2 -0.97 0 1.16 0 miRNATAP -0.33 4.0E-5 NA
71 hsa-miR-484 CRTAP -0.97 0 0.51 0 miRNAWalker2 validate; miRNATAP -0.15 0 NA
72 hsa-miR-484 CSDC2 -0.97 0 0.79 2.0E-5 mirMAP -0.16 0.01752 NA
73 hsa-miR-484 CTDSP2 -0.97 0 0.24 0.00016 miRNATAP -0.12 0 NA
74 hsa-miR-484 DAB2IP -0.97 0 0.86 0 mirMAP -0.16 0 NA
75 hsa-miR-484 DACH1 -0.97 0 0.21 0.10357 MirTarget; PITA; miRNATAP -0.29 0 NA
76 hsa-miR-484 DAGLA -0.97 0 0.38 0.00035 mirMAP -0.15 0.00011 NA
77 hsa-miR-484 DBNDD2 -0.97 0 1.29 0 PITA; miRNATAP -0.34 0 NA
78 hsa-miR-484 DCBLD2 -0.97 0 0.76 0 PITA; miRNATAP -0.34 0 NA
79 hsa-miR-484 DCHS1 -0.97 0 0.71 0 PITA; miRNATAP -0.33 0 NA
80 hsa-miR-484 DDI2 -0.97 0 0.4 0.09923 miRNAWalker2 validate -0.43 0 NA
81 hsa-miR-484 DENND1B -0.97 0 0.51 0.00058 miRNATAP -0.25 0 NA
82 hsa-miR-484 DENND5A -0.97 0 0.51 0 MirTarget; miRNATAP -0.13 0 NA
83 hsa-miR-484 DES -0.97 0 1.74 0 miRNATAP -0.68 0 NA
84 hsa-miR-484 DGKA -0.97 0 0.34 0.00372 miRNAWalker2 validate -0.11 0.00995 NA
85 hsa-miR-484 DHCR24 -0.97 0 -0.72 0 miRNAWalker2 validate -0.14 0.00692 NA
86 hsa-miR-484 DOK7 -0.97 0 0.99 0 mirMAP -0.2 0.00404 NA
87 hsa-miR-484 DPYSL2 -0.97 0 0.7 0 MirTarget; PITA; miRNATAP -0.2 0 NA
88 hsa-miR-484 DST -0.97 0 1.08 0 miRNAWalker2 validate -0.46 0 NA
89 hsa-miR-484 DSTN -0.97 0 0.63 0 miRNAWalker2 validate -0.2 0 NA
90 hsa-miR-484 DTX4 -0.97 0 0.48 1.0E-5 miRNATAP -0.28 0 NA
91 hsa-miR-484 DUSP3 -0.97 0 0.71 0 mirMAP -0.19 0 NA
92 hsa-miR-484 EDA2R -0.97 0 1.15 0 miRNAWalker2 validate -0.54 0 NA
93 hsa-miR-484 EFNB1 -0.97 0 1.33 0 PITA -0.26 0 NA
94 hsa-miR-484 EFNB3 -0.97 0 0.96 0 miRNAWalker2 validate -0.42 0 NA
95 hsa-miR-484 EGR3 -0.97 0 0.38 0.14781 PITA -0.3 0.00175 NA
96 hsa-miR-484 EIF4EBP2 -0.97 0 0.6 0 mirMAP -0.13 0 NA
97 hsa-miR-484 EIF4G2 -0.97 0 0.28 0 miRNAWalker2 validate; MirTarget; PITA; miRNATAP -0.11 0 NA
98 hsa-miR-484 EIF5B -0.97 0 0.25 0.00143 miRNAWalker2 validate -0.11 0.00011 NA
99 hsa-miR-484 EPB41L2 -0.97 0 0.89 0 miRNATAP -0.36 0 NA
100 hsa-miR-484 ERN2 -0.97 0 2.32 0 miRNATAP -1.22 0 NA
101 hsa-miR-484 EXOC5 -0.97 0 0.13 0.04464 miRNAWalker2 validate -0.11 1.0E-5 NA
102 hsa-miR-484 EXOC6B -0.97 0 0.82 1.0E-5 miRNAWalker2 validate -0.39 0 NA
103 hsa-miR-484 FAM129A -0.97 0 0.42 0.00201 miRNAWalker2 validate -0.27 0 NA
104 hsa-miR-484 FAM13A -0.97 0 0.15 0.0601 miRNATAP -0.13 0 NA
105 hsa-miR-484 FAM46A -0.97 0 1.02 0 miRNAWalker2 validate -0.15 0.00671 NA
106 hsa-miR-484 FAT2 -0.97 0 2.38 0 miRNATAP -0.92 0 NA
107 hsa-miR-484 FGF1 -0.97 0 0.64 0.00026 MirTarget; PITA; miRNATAP -0.37 0 NA
108 hsa-miR-484 FGF7 -0.97 0 1.48 0 PITA -0.53 0 NA
109 hsa-miR-484 FHL1 -0.97 0 1.71 0 PITA; miRNATAP -0.61 0 NA
110 hsa-miR-484 FLNA -0.97 0 1.5 0 miRNAWalker2 validate -0.6 0 NA
111 hsa-miR-484 FLVCR2 -0.97 0 0.21 0.05131 MirTarget -0.18 0 NA
112 hsa-miR-484 FMN1 -0.97 0 0.49 0.05658 mirMAP -0.66 0 NA
113 hsa-miR-484 FOSL2 -0.97 0 0.66 0 miRNATAP -0.3 0 NA
114 hsa-miR-484 FOXN3 -0.97 0 0.53 0 miRNATAP -0.21 0 NA
115 hsa-miR-484 FOXO4 -0.97 0 0.47 0 miRNATAP -0.13 0 NA
116 hsa-miR-484 FUT11 -0.97 0 0.18 0.07723 miRNAWalker2 validate -0.21 0 NA
117 hsa-miR-484 FYCO1 -0.97 0 0.54 0 miRNAWalker2 validate -0.26 0 NA
118 hsa-miR-484 G3BP2 -0.97 0 -0.14 0.06557 miRNAWalker2 validate -0.15 0 NA
119 hsa-miR-484 GAP43 -0.97 0 -0.18 0.4862 MirTarget; PITA; miRNATAP -0.2 0.03399 NA
120 hsa-miR-484 GFOD1 -0.97 0 0.69 0 miRNAWalker2 validate -0.28 0 NA
121 hsa-miR-484 GIPC3 -0.97 0 0.61 1.0E-5 mirMAP -0.12 0.01983 NA
122 hsa-miR-484 GJC1 -0.97 0 1.17 0 miRNATAP -0.35 0 NA
123 hsa-miR-484 GLCE -0.97 0 0.69 0 miRNAWalker2 validate -0.24 0 NA
124 hsa-miR-484 GLDN -0.97 0 2.04 0 MirTarget; miRNATAP -0.57 0 NA
125 hsa-miR-484 GLUL -0.97 0 0.58 0 miRNAWalker2 validate -0.17 0 NA
126 hsa-miR-484 GNA11 -0.97 0 0.57 0 mirMAP -0.26 0 NA
127 hsa-miR-484 GNAO1 -0.97 0 2.19 0 mirMAP -0.52 0 NA
128 hsa-miR-484 GPM6A -0.97 0 2.01 0 miRNATAP -0.75 0 NA
129 hsa-miR-484 GPR132 -0.97 0 -0.06 0.71545 mirMAP -0.13 0.01586 NA
130 hsa-miR-484 GPR173 -0.97 0 1.4 0 miRNATAP -0.5 0 NA
131 hsa-miR-484 GPR55 -0.97 0 0.5 0.00788 mirMAP -0.3 1.0E-5 NA
132 hsa-miR-484 GPR63 -0.97 0 -0.04 0.82215 PITA -0.33 0 NA
133 hsa-miR-484 GPX3 -0.97 0 1.46 0 miRNATAP -0.5 0 NA
134 hsa-miR-484 GRAMD1B -0.97 0 1.28 0 mirMAP -0.26 0.00045 NA
135 hsa-miR-484 GRAMD1C -0.97 0 0.07 0.59828 MirTarget -0.2 2.0E-5 NA
136 hsa-miR-484 GREM1 -0.97 0 0.02 0.95259 PITA -0.34 0.00054 NA
137 hsa-miR-484 GRIA3 -0.97 0 1.6 0 PITA -0.56 0 NA
138 hsa-miR-484 GRIK3 -0.97 0 0.63 0.00211 mirMAP -0.28 0.00018 NA
139 hsa-miR-484 GTF2H3 -0.97 0 0.32 0.00435 miRNAWalker2 validate -0.24 0 NA
140 hsa-miR-484 GTF2I -0.97 0 0.3 0.03125 miRNAWalker2 validate -0.26 0 NA
141 hsa-miR-484 GTF3C3 -0.97 0 0.17 0.03159 miRNAWalker2 validate -0.14 0 NA
142 hsa-miR-484 H6PD -0.97 0 0.26 0.00011 mirMAP -0.15 0 NA
143 hsa-miR-484 HAS3 -0.97 0 1 0 miRNATAP -0.33 0 NA
144 hsa-miR-484 HES2 -0.97 0 -0.22 0.24177 mirMAP -0.31 0 NA
145 hsa-miR-484 HHIPL1 -0.97 0 0.57 5.0E-5 mirMAP -0.17 0.00093 NA
146 hsa-miR-484 HHIPL2 -0.97 0 1.38 0 MirTarget -0.6 0 NA
147 hsa-miR-484 HIPK1 -0.97 0 0.28 0.00021 miRNAWalker2 validate; MirTarget; PITA; miRNATAP -0.14 0 NA
148 hsa-miR-484 HIVEP2 -0.97 0 0.33 0.00366 miRNAWalker2 validate; PITA; miRNATAP -0.14 0.00069 NA
149 hsa-miR-484 HIVEP3 -0.97 0 -0.08 0.46148 MirTarget; miRNATAP -0.17 0 NA
150 hsa-miR-484 HMGCS1 -0.97 0 0.52 0 PITA -0.13 0.00023 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 LOCOMOTION 52 1114 1.055e-09 3.953e-06
2 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 56 1275 2.051e-09 3.953e-06
3 CELL DEVELOPMENT 60 1426 2.549e-09 3.953e-06
4 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 68 1784 1.068e-08 1.242e-05
5 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 36 724 1.045e-07 9.424e-05
6 NEUROGENESIS 55 1402 1.361e-07 9.424e-05
7 MULTI ORGANISM BEHAVIOR 11 75 1.418e-07 9.424e-05
8 POSITIVE REGULATION OF CELL PROLIFERATION 38 814 2.266e-07 0.0001318
9 NEURON PROJECTION DEVELOPMENT 29 545 4.893e-07 0.0001946
10 POSITIVE REGULATION OF GENE EXPRESSION 62 1733 5.018e-07 0.0001946
11 NEURON DIFFERENTIATION 39 874 4.89e-07 0.0001946
12 REGULATION OF CELL PROLIFERATION 56 1496 4.742e-07 0.0001946
13 NEURON DEVELOPMENT 33 687 7.901e-07 0.0002828
14 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 62 1805 1.964e-06 0.0006527
15 CELL JUNCTION ORGANIZATION 15 185 2.205e-06 0.0006704
16 NEURON PROJECTION MORPHOGENESIS 23 402 2.305e-06 0.0006704
17 CELL MOTILITY 36 835 3.034e-06 0.0007844
18 LOCALIZATION OF CELL 36 835 3.034e-06 0.0007844
19 REGULATION OF CELLULAR COMPONENT MOVEMENT 34 771 3.564e-06 0.0008727
20 BLOOD VESSEL MORPHOGENESIS 21 364 5.601e-06 0.001061
21 CELL JUNCTION ASSEMBLY 12 129 5.627e-06 0.001061
22 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 40 1004 5.699e-06 0.001061
23 CARDIOVASCULAR SYSTEM DEVELOPMENT 34 788 5.692e-06 0.001061
24 CIRCULATORY SYSTEM DEVELOPMENT 34 788 5.692e-06 0.001061
25 BEHAVIOR 26 516 5.207e-06 0.001061
26 CELLULAR COMPONENT MORPHOGENESIS 37 900 6.503e-06 0.001149
27 MUSCLE SYSTEM PROCESS 18 282 6.668e-06 0.001149
28 MUSCLE CONTRACTION 16 233 8.715e-06 0.001448
29 VASCULATURE DEVELOPMENT 24 469 9.328e-06 0.001497
30 BIOLOGICAL ADHESION 40 1032 1.087e-05 0.001686
31 SECRETION BY CELL 24 486 1.676e-05 0.002395
32 TUBE DEVELOPMENT 26 552 1.698e-05 0.002395
33 TISSUE DEVELOPMENT 52 1518 1.602e-05 0.002395
34 SYNAPSE ORGANIZATION 12 145 1.86e-05 0.002404
35 SECRETION 27 588 1.833e-05 0.002404
36 DEVELOPMENTAL GROWTH 19 333 1.824e-05 0.002404
37 COGNITION 16 251 2.198e-05 0.002764
38 MUSCLE STRUCTURE DEVELOPMENT 22 432 2.369e-05 0.002901
39 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 37 957 2.501e-05 0.002922
40 REGULATION OF GROWTH 28 633 2.512e-05 0.002922
41 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 55 1672 2.775e-05 0.003149
42 REGULATION OF SYSTEM PROCESS 24 507 3.315e-05 0.00364
43 NEURON PROJECTION GUIDANCE 14 205 3.364e-05 0.00364
44 CELL PROJECTION ORGANIZATION 35 902 3.884e-05 0.004107
45 REGULATION OF CELL DIFFERENTIATION 50 1492 4.189e-05 0.004332
46 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 38 1021 4.408e-05 0.004459
47 CELL PART MORPHOGENESIS 27 633 6.511e-05 0.006446
48 TAXIS 22 464 6.879e-05 0.006669
49 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 19 368 7.079e-05 0.006722
50 EXOCYTOSIS 17 310 8.168e-05 0.007456
51 REGULATION OF MUSCLE SYSTEM PROCESS 13 195 8.172e-05 0.007456
52 ENTRAINMENT OF CIRCADIAN CLOCK 5 26 0.0001059 0.009327
53 CELL SUBSTRATE JUNCTION ASSEMBLY 6 41 0.0001062 0.009327
54 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 23 513 0.0001093 0.009421
NumGOOverlapSizeP ValueAdj. P Value
1 MACROMOLECULAR COMPLEX BINDING 55 1399 1.269e-07 0.0001179
2 ENZYME BINDING 62 1737 5.429e-07 0.0002522
3 TRANSCRIPTION FACTOR BINDING 27 524 2.254e-06 0.0006979
4 KINASE BINDING 29 606 4.056e-06 0.0009197
5 REGULATORY REGION NUCLEIC ACID BINDING 35 818 4.95e-06 0.0009197
6 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 29 629 8.279e-06 0.0009614
7 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 45 1199 6.737e-06 0.0009614
8 RECEPTOR BINDING 52 1476 7.385e-06 0.0009614
9 RAB GTPASE BINDING 11 120 1.587e-05 0.001638
10 CYTOSKELETAL PROTEIN BINDING 33 819 3.129e-05 0.002907
11 DOUBLE STRANDED DNA BINDING 31 764 4.803e-05 0.004057
12 CALCIUM ION BINDING 29 697 5.439e-05 0.004211
13 PROTEIN COMPLEX BINDING 35 935 7.971e-05 0.005696
14 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 17 328 0.0001613 0.009365
15 GROWTH FACTOR RECEPTOR BINDING 10 129 0.0001586 0.009365
16 GTPASE BINDING 16 295 0.0001494 0.009365
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 50 1151 2.386e-08 1.394e-05
2 ANCHORING JUNCTION 26 489 1.967e-06 0.0005745
3 NEURON PART 47 1265 5.391e-06 0.0006823
4 INTRINSIC COMPONENT OF PLASMA MEMBRANE 57 1649 4.505e-06 0.0006823
5 SYNAPSE 33 754 5.842e-06 0.0006823
6 CELL PROJECTION PART 37 946 1.95e-05 0.001898
7 NEURON PROJECTION 36 942 4.113e-05 0.003432
8 CELL SUBSTRATE JUNCTION 20 398 6.667e-05 0.004867
9 CELL PROJECTION 56 1786 8.641e-05 0.005204
10 MEMBRANE REGION 40 1134 8.911e-05 0.005204
11 POSTSYNAPSE 19 378 0.0001007 0.005347
12 CELL CELL JUNCTION 19 383 0.0001195 0.005816

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 13 163 1.251e-05 0.0006294
2 Focal_adhesion_hsa04510 14 199 2.421e-05 0.0006294
3 Calcium_signaling_pathway_hsa04020 12 182 0.0001692 0.002933
4 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.0004088 0.005315
5 cAMP_signaling_pathway_hsa04024 11 198 0.001303 0.01277
6 Ras_signaling_pathway_hsa04014 12 232 0.001474 0.01277
7 ErbB_signaling_pathway_hsa04012 6 85 0.0052 0.03257
8 Rap1_signaling_pathway_hsa04015 10 206 0.005563 0.03257
9 Regulation_of_actin_cytoskeleton_hsa04810 10 208 0.005944 0.03257
10 Wnt_signaling_pathway_hsa04310 8 146 0.006264 0.03257
11 Oocyte_meiosis_hsa04114 7 124 0.008803 0.04161
12 Cellular_senescence_hsa04218 8 160 0.01061 0.04176
13 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.01073 0.04176
14 HIF_1_signaling_pathway_hsa04066 6 100 0.01124 0.04176
15 PI3K_Akt_signaling_pathway_hsa04151 13 352 0.01571 0.05447
16 ECM_receptor_interaction_hsa04512 5 82 0.0188 0.06111
17 MAPK_signaling_pathway_hsa04010 11 295 0.02359 0.07215
18 Jak_STAT_signaling_pathway_hsa04630 7 162 0.03295 0.0952
19 Ferroptosis_hsa04216 3 40 0.03851 0.1054
20 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.06813 0.1771
21 Autophagy_animal_hsa04140 5 128 0.09252 0.2211
22 VEGF_signaling_pathway_hsa04370 3 59 0.09825 0.2211
23 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.1018 0.2211
24 FoxO_signaling_pathway_hsa04068 5 132 0.1021 0.2211
25 p53_signaling_pathway_hsa04115 3 68 0.1345 0.2798
26 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.1516 0.2957
27 mTOR_signaling_pathway_hsa04150 5 151 0.1536 0.2957
28 Sphingolipid_signaling_pathway_hsa04071 4 118 0.18 0.3336
29 AMPK_signaling_pathway_hsa04152 4 121 0.1912 0.3336
30 Necroptosis_hsa04217 5 164 0.1939 0.3336
31 Lysosome_hsa04142 4 123 0.1989 0.3336
32 Gap_junction_hsa04540 3 88 0.2274 0.3695
33 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.2624 0.4134
34 Phagosome_hsa04145 4 152 0.317 0.4848
35 TNF_signaling_pathway_hsa04668 3 108 0.3287 0.4883
36 Tight_junction_hsa04530 4 170 0.3933 0.5681
37 Endocytosis_hsa04144 5 244 0.4814 0.6614
38 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.4833 0.6614
39 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.5161 0.6881
40 Hippo_signaling_pathway_hsa04390 3 154 0.5521 0.7177
41 Cell_cycle_hsa04110 2 124 0.6772 0.8385
42 Apelin_signaling_pathway_hsa04371 2 137 0.7291 0.8408
43 Apoptosis_hsa04210 2 138 0.7328 0.8408

Quest ID: 869b0a5c13730776fe4cc44dfc8a0532