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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p ABAT 1.05 0 -0.36 2.0E-5 MirTarget -0.26 0 NA
2 hsa-miR-21-3p ABI2 1.35 0 -0.18 0.00158 MirTarget -0.1 0 NA
3 hsa-miR-21-5p ACBD5 1.05 0 -0.31 0 miRNAWalker2 validate; miRNATAP -0.12 0 NA
4 hsa-miR-21-5p ACVR2A 1.05 0 -0.12 0.00732 miRNATAP -0.11 0 NA
5 hsa-miR-21-5p ADCY2 1.05 0 -0.55 0 MirTarget -0.18 0 NA
6 hsa-miR-21-3p AFF2 1.35 0 -0.95 0 mirMAP -0.44 0 NA
7 hsa-miR-21-3p AKAP11 1.35 0 -0.32 0 MirTarget -0.12 0 NA
8 hsa-miR-21-5p AKAP6 1.05 0 -0.54 0 MirTarget -0.18 0 NA
9 hsa-miR-21-3p ALCAM 1.35 0 -0.28 0.0005 MirTarget -0.12 0 27153478 Enhanced expression of CD44 CD166 and miR-21 with miR-215 was found in the specimens obtained at follow-up despite alleviation of mucosal lesions
10 hsa-miR-21-3p AMOT 1.35 0 -0.5 0 mirMAP -0.14 0 NA
11 hsa-miR-21-5p ANKRD46 1.05 0 -0.33 0 miRNAWalker2 validate; miRTarBase -0.21 0 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC
12 hsa-miR-21-5p ANKS1B 1.05 0 -0.43 0.0001 MirTarget -0.26 0 NA
13 hsa-miR-21-5p ANO3 1.05 0 -0.68 6.0E-5 mirMAP -0.4 0 NA
14 hsa-miR-21-5p ARHGAP32 1.05 0 -0.39 0 MirTarget -0.18 0 NA
15 hsa-miR-21-3p ARHGAP36 1.35 0 -0.92 0 MirTarget -0.28 0 NA
16 hsa-miR-21-3p ARMC5 1.35 0 -0.09 0.0844 mirMAP -0.11 0 NA
17 hsa-miR-21-3p ASB1 1.35 0 -0.22 0.00013 MirTarget -0.12 0 NA
18 hsa-miR-21-5p ASF1A 1.05 0 -0.17 0.00103 miRNATAP -0.12 0 NA
19 hsa-miR-21-5p ASRGL1 1.05 0 -0.32 0 miRNAWalker2 validate -0.2 0 NA
20 hsa-miR-21-5p ATP2B2 1.05 0 -0.46 1.0E-5 mirMAP -0.32 0 NA
21 hsa-miR-21-3p ATRNL1 1.35 0 -0.54 0 MirTarget -0.22 0 NA
22 hsa-miR-21-5p ATRNL1 1.05 0 -0.54 0 MirTarget -0.26 0 NA
23 hsa-miR-21-5p ATRX 1.05 0 0 0.99249 miRNAWalker2 validate -0.11 5.0E-5 NA
24 hsa-miR-21-5p AUTS2 1.05 0 -0.06 0.29094 miRNAWalker2 validate -0.12 0 NA
25 hsa-miR-21-5p B3GAT2 1.05 0 -0.63 0 MirTarget -0.4 0 NA
26 hsa-miR-21-3p B4GALT6 1.35 0 -0.32 0.0003 MirTarget -0.11 0 NA
27 hsa-miR-21-5p BASP1 1.05 0 -0.49 0 miRNAWalker2 validate; miRTarBase -0.28 0 NA
28 hsa-miR-21-5p BEST3 1.05 0 -0.16 0.28659 MirTarget -0.2 2.0E-5 NA
29 hsa-miR-21-5p BTBD9 1.05 0 -0.2 0.0002 mirMAP -0.1 0 NA
30 hsa-miR-21-5p C11orf87 1.05 0 -0.5 0.02872 mirMAP; miRNATAP -0.41 0 NA
31 hsa-miR-21-5p C16orf52 1.05 0 -0.2 1.0E-5 miRNATAP -0.11 0 NA
32 hsa-miR-21-5p C8orf44 1.05 0 -0.2 0 mirMAP -0.11 0 NA
33 hsa-miR-21-5p CACNA1E 1.05 0 -0.57 0.0001 mirMAP -0.45 0 NA
34 hsa-miR-21-3p CACNA2D1 1.35 0 -0.73 0.00011 mirMAP -0.26 0 NA
35 hsa-miR-10b-5p CACNA2D2 1.55 0 -0.74 0 mirMAP -0.12 0 NA
36 hsa-miR-21-5p CADM2 1.05 0 -0.51 0 mirMAP; miRNATAP -0.24 0 NA
37 hsa-miR-10b-5p CALN1 1.55 0 -1.22 0 mirMAP -0.22 0 NA
38 hsa-miR-21-5p CALN1 1.05 0 -1.22 0 mirMAP -0.66 0 NA
39 hsa-miR-10b-5p CAMK2A 1.55 0 -1.05 2.0E-5 mirMAP -0.18 0 NA
40 hsa-miR-21-3p CAMK2A 1.35 0 -1.05 2.0E-5 MirTarget -0.52 0 NA
41 hsa-miR-10b-5p CAMK2B 1.55 0 -0.33 0.02297 miRNATAP -0.1 1.0E-5 NA
42 hsa-miR-21-5p CAMK4 1.05 0 -0.57 0.00246 mirMAP -0.57 0 NA
43 hsa-miR-21-3p CAMLG 1.35 0 -0.19 0.00063 MirTarget -0.13 0 NA
44 hsa-miR-21-5p CASK 1.05 0 -0.16 0.01486 mirMAP -0.11 0 NA
45 hsa-miR-21-5p CASKIN1 1.05 0 -0.74 0 MirTarget -0.5 0 NA
46 hsa-miR-21-5p CCNG2 1.05 0 -0.12 0.03505 mirMAP -0.13 0 NA
47 hsa-miR-21-5p CEP68 1.05 0 -0.14 0.00545 miRNATAP -0.12 0 NA
48 hsa-miR-10b-5p CHD5 1.55 0 -0.9 0 mirMAP -0.11 0.00021 NA
49 hsa-miR-21-3p CHD5 1.35 0 -0.9 0 mirMAP -0.33 0 NA
50 hsa-miR-21-3p CHRNA7 1.35 0 -0.98 0 mirMAP -0.35 0 NA
51 hsa-miR-21-5p CLIP4 1.05 0 -0.3 0 miRNAWalker2 validate -0.12 0 NA
52 hsa-miR-21-3p CNRIP1 1.35 0 -0.45 0 MirTarget -0.24 0 NA
53 hsa-miR-21-5p CNTFR 1.05 0 -0.3 0.00501 miRNATAP -0.42 0 NA
54 hsa-miR-10b-5p CNTN2 1.55 0 -0.5 0.00779 mirMAP -0.14 0 NA
55 hsa-miR-21-3p CNTNAP4 1.35 0 -0.92 0 MirTarget -0.28 0 NA
56 hsa-miR-21-5p CPEB3 1.05 0 -0.56 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.27 0 NA
57 hsa-miR-21-3p CPLX2 1.35 0 -0.92 2.0E-5 mirMAP -0.67 0 NA
58 hsa-miR-21-5p CRB1 1.05 0 -0.11 0.25834 mirMAP -0.18 0 NA
59 hsa-miR-10b-5p CSMD1 1.55 0 -0.81 0 MirTarget; miRNATAP -0.13 0 27756250 miR 10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 CSMD1; Forty-five paired human HCC and adjacent non-tumor tissues were collected for qRT-PCR and immunohistochemistry analysis of miR-10b and CUB and Sushi multiple domains 1 CSMD1 respectively; We analyzed the clinicopathological data from these patients to further determine if there was an association between miR-10b and CSMD1; Luciferase assay was used to assess miR-10b binding to the 3'-untranslated region 3'-UTR of CSMD1 miR-10b was highly expressed in HCC tissues compared to normal tissues; Bioinformatics and luciferase reporter assay demonstrated that CSMD1 was the target gene of miR-10b; Immunocytochemical immunohistochemical and qRT-PCR data indicated that miR-10b decreased CSMD1 expression in HCC cells; We showed that miR-10b is overexpressed in HCC tissues and miR-10b mimics promoted HCC cell viability and invasion via targeting CSMD1 expression; Our findings suggest that miR-10b acts as an oncogene by targeting the tumor suppressor gene CSMD1 in HCC
60 hsa-miR-21-5p CSRNP3 1.05 0 -0.29 0.02242 miRNATAP -0.26 0 NA
61 hsa-miR-21-3p CTNNA3 1.35 0 -0.59 2.0E-5 MirTarget -0.3 0 NA
62 hsa-miR-21-5p CXXC4 1.05 0 -0.28 0.01503 mirMAP -0.31 0 NA
63 hsa-miR-21-3p DGKE 1.35 0 -0.45 4.0E-5 mirMAP -0.13 2.0E-5 NA
64 hsa-miR-21-5p DLGAP1 1.05 0 -0.62 0 miRNATAP -0.38 0 NA
65 hsa-miR-10b-5p DLGAP2 1.55 0 -1.13 0 miRNATAP -0.19 0 NA
66 hsa-miR-21-5p DLGAP2 1.05 0 -1.13 0 mirMAP -0.62 0 NA
67 hsa-miR-21-5p DOK6 1.05 0 -0.64 0 mirMAP -0.45 0 NA
68 hsa-miR-21-5p DUSP8 1.05 0 -0.18 0.03829 miRNAWalker2 validate; MirTarget -0.22 0 NA
69 hsa-miR-21-3p DYNC1I1 1.35 0 -0.58 0 MirTarget -0.27 0 NA
70 hsa-miR-21-5p EDIL3 1.05 0 -0.62 7.0E-5 miRNAWalker2 validate; MirTarget -0.12 0.01175 NA
71 hsa-miR-21-3p EFNA5 1.35 0 -0.48 0.00105 mirMAP -0.18 1.0E-5 NA
72 hsa-miR-21-5p EGFR 1.05 0 0.38 0.01555 miRNAWalker2 validate; miRTarBase -0.12 0.01176 20113523; 24012640; 20048743; 24198203; 24331411; 26563758; 19597153; 26026961 Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status;In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression
73 hsa-miR-21-5p EIF4A2 1.05 0 -0.23 0.00025 miRNAWalker2 validate; miRTarBase -0.11 0 NA
74 hsa-miR-10b-5p ELAVL2 1.55 0 -0.63 2.0E-5 MirTarget; miRNATAP -0.1 1.0E-5 NA
75 hsa-miR-21-5p ELAVL4 1.05 0 -0.64 4.0E-5 miRNAWalker2 validate -0.42 0 NA
76 hsa-miR-21-3p ELMO1 1.35 0 -0.21 0.00946 MirTarget -0.14 0 NA
77 hsa-miR-21-5p ELOVL4 1.05 0 -0.17 0.03111 miRNAWalker2 validate -0.18 0 NA
78 hsa-miR-21-3p ETV1 1.35 0 -0.13 0.31231 MirTarget -0.19 0 NA
79 hsa-miR-21-5p FAM126B 1.05 0 -0.2 0.0006 miRNAWalker2 validate -0.14 0 NA
80 hsa-miR-21-3p FAT3 1.35 0 -0.36 0.0001 MirTarget -0.15 0 NA
81 hsa-miR-21-5p FBXL17 1.05 0 -0.23 1.0E-5 miRNAWalker2 validate; miRNATAP -0.11 0 NA
82 hsa-miR-21-5p FMR1 1.05 0 -0.17 0.00018 miRNAWalker2 validate -0.11 0 NA
83 hsa-miR-21-5p FOXP2 1.05 0 -0.58 0.00247 mirMAP -0.16 0.00954 NA
84 hsa-miR-10b-5p GABRG1 1.55 0 -1.55 0 MirTarget -0.26 0 NA
85 hsa-miR-21-3p GAD2 1.35 0 -0.39 0.1058 MirTarget -0.43 0 NA
86 hsa-miR-21-5p GAD2 1.05 0 -0.39 0.1058 mirMAP -0.55 0 NA
87 hsa-miR-21-5p GFOD1 1.05 0 -0.1 0.29503 mirMAP -0.17 0 NA
88 hsa-miR-21-5p GLCCI1 1.05 0 -0.08 0.35291 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0 NA
89 hsa-miR-21-5p GLIS2 1.05 0 -0.02 0.73656 miRNATAP -0.13 0 NA
90 hsa-miR-21-3p GNAZ 1.35 0 -0.26 5.0E-5 MirTarget -0.13 0 NA
91 hsa-miR-21-5p GPAM 1.05 0 -0.34 0 miRNAWalker2 validate; mirMAP -0.14 0 NA
92 hsa-miR-21-5p GPD1L 1.05 0 -0.28 5.0E-5 miRNAWalker2 validate -0.13 0 NA
93 hsa-miR-10b-5p GRIN1 1.55 0 -1.21 0 mirMAP -0.22 0 NA
94 hsa-miR-10b-5p GRIN3A 1.55 0 -1.17 0 miRNATAP -0.22 0 NA
95 hsa-miR-21-3p GRM5 1.35 0 -0.56 0.00146 MirTarget -0.41 0 NA
96 hsa-miR-21-5p HAPLN1 1.05 0 -0.79 1.0E-5 miRNAWalker2 validate -0.58 0 NA
97 hsa-miR-21-3p HIPK2 1.35 0 -0.36 1.0E-5 mirMAP -0.14 0 NA
98 hsa-miR-21-5p HMGB3 1.05 0 0.11 0.09319 miRNAWalker2 validate -0.12 0 NA
99 hsa-miR-21-3p HOOK1 1.35 0 -0.64 0.00034 MirTarget -0.25 0 NA
100 hsa-miR-21-5p IDS 1.05 0 -0.45 3.0E-5 mirMAP -0.18 0 NA
101 hsa-miR-10b-5p IGSF1 1.55 0 -0.94 0 miRNAWalker2 validate -0.12 0 NA
102 hsa-miR-21-5p IL12A 1.05 0 -0.21 0.03398 MirTarget -0.15 0 NA
103 hsa-miR-21-5p INPP4B 1.05 0 -0.23 0.02693 mirMAP -0.12 0.00023 NA
104 hsa-miR-21-3p INSIG1 1.35 0 -0.28 0.00041 MirTarget -0.15 0 NA
105 hsa-miR-10b-5p IPCEF1 1.55 0 -0.64 0 miRNAWalker2 validate -0.11 0 NA
106 hsa-miR-21-3p IPCEF1 1.35 0 -0.64 0 MirTarget -0.16 3.0E-5 NA
107 hsa-miR-21-5p JMY 1.05 0 -0.19 0.00012 miRNAWalker2 validate; mirMAP -0.11 0 NA
108 hsa-miR-21-5p JPH1 1.05 0 -0.32 0.03054 miRNAWalker2 validate; miRNATAP -0.11 0.01494 NA
109 hsa-miR-21-3p KBTBD11 1.35 0 -0.65 0 mirMAP -0.25 0 NA
110 hsa-miR-21-5p KBTBD6 1.05 0 -0.24 4.0E-5 miRNAWalker2 validate; MirTarget -0.18 0 NA
111 hsa-miR-21-5p KBTBD7 1.05 0 -0.29 0.00056 miRNAWalker2 validate -0.2 0 NA
112 hsa-miR-21-5p KCNA1 1.05 0 -0.43 0.02455 miRNATAP -0.22 0.00019 NA
113 hsa-miR-21-5p KCNA3 1.05 0 0.02 0.90081 miRNATAP -0.15 0.00183 NA
114 hsa-miR-21-3p KCNC1 1.35 0 -0.33 0.00459 mirMAP -0.26 0 NA
115 hsa-miR-21-5p KCNK3 1.05 0 -0.75 1.0E-5 mirMAP -0.62 0 NA
116 hsa-miR-21-3p KIAA1211 1.35 0 -0.19 0.01054 MirTarget -0.13 0 NA
117 hsa-miR-21-3p KIAA1462 1.35 0 -0.08 0.28914 MirTarget -0.11 0 NA
118 hsa-miR-21-5p KIAA1671 1.05 0 -0.51 0 mirMAP -0.11 0 NA
119 hsa-miR-21-3p KIF5C 1.35 0 -0.22 0.01806 mirMAP -0.15 0 NA
120 hsa-miR-21-3p KIRREL3 1.35 0 -0.37 0.01968 MirTarget -0.17 9.0E-5 NA
121 hsa-miR-21-5p KLF12 1.05 0 -0.16 0.01906 mirMAP -0.17 0 NA
122 hsa-miR-21-5p KSR2 1.05 0 -1.41 0 mirMAP -0.78 0 NA
123 hsa-miR-21-3p L2HGDH 1.35 0 -0.26 0 MirTarget -0.1 0 NA
124 hsa-miR-21-5p LANCL1 1.05 0 -0.22 0.00051 MirTarget -0.11 0 NA
125 hsa-miR-21-3p LANCL2 1.35 0 -0.05 0.52633 MirTarget -0.1 0 NA
126 hsa-miR-21-5p LIFR 1.05 0 -0.39 3.0E-5 miRNAWalker2 validate -0.13 0 NA
127 hsa-miR-21-3p LONRF2 1.35 0 -0.34 0.00012 mirMAP -0.14 0 NA
128 hsa-miR-21-5p LONRF2 1.05 0 -0.34 0.00012 miRNAWalker2 validate -0.19 0 NA
129 hsa-miR-21-3p LRRC27 1.35 0 -0.19 0.00033 mirMAP -0.1 0 NA
130 hsa-miR-21-3p LYNX1 1.35 0 -0.5 0 mirMAP -0.18 0 NA
131 hsa-miR-21-5p LYRM7 1.05 0 -0.12 0.01808 miRNAWalker2 validate -0.13 0 NA
132 hsa-miR-21-3p MAGEL2 1.35 0 -0.44 1.0E-5 MirTarget -0.27 0 NA
133 hsa-miR-10b-5p MARCH4 1.55 0 -0.74 0.00051 mirMAP -0.14 2.0E-5 NA
134 hsa-miR-21-5p MARCKS 1.05 0 -0.11 0.19006 miRNAWalker2 validate; miRTarBase -0.14 0 19302977 MicroRNA 21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
135 hsa-miR-21-5p MBLAC2 1.05 0 -0.14 0.00894 MirTarget -0.13 0 NA
136 hsa-miR-21-5p MBP 1.05 0 -0.89 4.0E-5 mirMAP -0.17 0.01059 NA
137 hsa-miR-21-5p MDGA2 1.05 0 -0.75 0 miRNATAP -0.35 0 NA
138 hsa-miR-21-5p MEGF11 1.05 0 -0.33 0.01622 mirMAP -0.32 0 NA
139 hsa-miR-21-5p MIB1 1.05 0 -0.2 0.00153 miRNAWalker2 validate; mirMAP -0.12 0 NA
140 hsa-miR-21-3p MLC1 1.35 0 -0.47 3.0E-5 MirTarget -0.17 0 NA
141 hsa-miR-21-5p MOAP1 1.05 0 -0.37 0 miRNAWalker2 validate -0.21 0 NA
142 hsa-miR-21-5p MRAP2 1.05 0 -0.13 0.49478 miRNAWalker2 validate -0.18 0.00191 NA
143 hsa-miR-21-5p MTMR9 1.05 0 -0.21 0.00012 miRNAWalker2 validate -0.13 0 NA
144 hsa-miR-21-3p MUM1L1 1.35 0 -1.07 0 MirTarget -0.35 0 NA
145 hsa-miR-21-5p MYCBP2 1.05 0 -0.35 0 miRNAWalker2 validate -0.16 0 NA
146 hsa-miR-21-5p N4BP2L1 1.05 0 -0.28 0 MirTarget -0.11 0 NA
147 hsa-miR-21-3p N6AMT1 1.35 0 -0.13 0.03213 mirMAP -0.11 0 NA
148 hsa-miR-21-3p NAP1L5 1.35 0 -0.39 0 MirTarget -0.16 0 NA
149 hsa-miR-21-3p NAV3 1.35 0 -0.43 0 MirTarget -0.12 0 25579119 We identify NAV3 as a potential target of miR-21-3p and show that knockdown of NAV3 increases resistance; Finally we use publically available transcriptomic data to demonstrate that miR-21-3p is raised while NAV3 is reduced in ovarian tumours that are resistant to platinum treatment; Our data suggest that miR-21-3p can induce cisplatin resistance in ovarian tumours potentially by targeting the NAV3 gene
150 hsa-miR-21-5p NBEA 1.05 0 -0.37 1.0E-5 miRNAWalker2 validate; miRNATAP -0.24 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 MODULATION OF SYNAPTIC TRANSMISSION 22 301 1.205e-10 5.609e-07
2 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 15 153 2.208e-09 5.136e-06
3 BEHAVIOR 26 516 7.299e-09 1.132e-05
4 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 16 204 1.627e-08 1.893e-05
5 SINGLE ORGANISM BEHAVIOR 21 384 5.486e-08 5.105e-05
6 CENTRAL NERVOUS SYSTEM DEVELOPMENT 32 872 2.299e-07 0.0001783
7 REGULATION OF SYNAPTIC PLASTICITY 12 140 4.014e-07 0.000246
8 REGULATION OF ION TRANSPORT 25 592 4.23e-07 0.000246
9 REGULATION OF TRANSPORT 50 1804 5.115e-07 0.0002645
10 HEAD DEVELOPMENT 27 709 1.072e-06 0.0004987
11 SYNAPTIC SIGNALING 20 424 1.19e-06 0.0005036
12 REGULATION OF NEUROTRANSMITTER LEVELS 13 190 1.739e-06 0.0006745
13 CALCIUM ION TRANSPORT 14 223 1.931e-06 0.000691
14 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 14 232 3.07e-06 0.0009608
15 BIOLOGICAL ADHESION 33 1032 3.097e-06 0.0009608
16 DIVALENT INORGANIC CATION TRANSPORT 15 268 3.445e-06 0.001002
17 CELL CELL ADHESION 23 608 7.781e-06 0.00213
18 METAL ION TRANSPORT 22 582 1.248e-05 0.003227
19 ADULT BEHAVIOR 10 135 1.384e-05 0.00339
20 REGULATION OF TRANSMEMBRANE TRANSPORT 18 426 1.84e-05 0.00428
21 NEUROGENESIS 38 1402 2.407e-05 0.005332
22 FOREBRAIN DEVELOPMENT 16 357 2.658e-05 0.005622
23 LONG TERM MEMORY 5 28 3.122e-05 0.006315
24 REGULATION OF NEURONAL SYNAPTIC PLASTICITY 6 49 4.624e-05 0.008965
NumGOOverlapSizeP ValueAdj. P Value
1 CALCIUM ION BINDING 29 697 6.525e-08 6.062e-05
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 51 1265 9.881e-13 5.771e-10
2 SYNAPSE 37 754 7.784e-12 2.273e-09
3 SYNAPSE PART 31 610 1.91e-10 3.718e-08
4 NEURON PROJECTION 38 942 1.135e-09 1.657e-07
5 AXON 22 418 5.153e-08 4.535e-06
6 SOMATODENDRITIC COMPARTMENT 28 650 5.436e-08 4.535e-06
7 DENDRITE 23 451 4.506e-08 4.535e-06
8 CELL PROJECTION 50 1786 3.789e-07 2.766e-05
9 EXCITATORY SYNAPSE 14 197 4.378e-07 2.841e-05
10 POSTSYNAPSE 19 378 8.649e-07 5.051e-05
11 PRESYNAPSE 16 283 1.421e-06 7.545e-05
12 SYNAPTIC MEMBRANE 15 261 2.489e-06 0.0001211
13 MEMBRANE PROTEIN COMPLEX 32 1020 6.551e-06 0.0002943
14 TRANSPORTER COMPLEX 16 321 7.156e-06 0.0002985
15 AXON PART 13 219 8.284e-06 0.0003225
16 PLASMA MEMBRANE PROTEIN COMPLEX 20 510 1.857e-05 0.0006778
17 CELL JUNCTION 33 1151 2.924e-05 0.001004
18 PLASMA MEMBRANE REGION 28 929 5.21e-05 0.00169
19 RECEPTOR COMPLEX 14 327 0.0001372 0.004217
20 NEURON SPINE 8 121 0.0002227 0.006504
21 MEMBRANE REGION 30 1134 0.000281 0.007815
22 NEURON PROJECTION TERMINUS 8 129 0.0003444 0.009142
23 CELL BODY 17 494 0.0003705 0.009407
24 CATION CHANNEL COMPLEX 9 167 0.0004209 0.009832
25 CELL PROJECTION PART 26 946 0.0004113 0.009832

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Calcium_signaling_pathway_hsa04020 13 182 1.073e-06 5.577e-05
2 cAMP_signaling_pathway_hsa04024 10 198 0.0003422 0.008897
3 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.01376 0.1561
4 Wnt_signaling_pathway_hsa04310 6 146 0.01376 0.1561
5 Hippo_signaling_pathway_hsa04390 6 154 0.01747 0.1561
6 MAPK_signaling_pathway_hsa04010 9 295 0.01801 0.1561
7 Oocyte_meiosis_hsa04114 5 124 0.0255 0.1762
8 ErbB_signaling_pathway_hsa04012 4 85 0.0271 0.1762
9 Ras_signaling_pathway_hsa04014 7 232 0.03665 0.2118
10 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.0437 0.213
11 HIF_1_signaling_pathway_hsa04066 4 100 0.04507 0.213
12 Jak_STAT_signaling_pathway_hsa04630 5 162 0.06645 0.2664
13 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.06784 0.2664
14 Adherens_junction_hsa04520 3 72 0.07173 0.2664
15 Neuroactive_ligand_receptor_interaction_hsa04080 7 278 0.08002 0.2774
16 Apelin_signaling_pathway_hsa04371 4 137 0.1114 0.3347
17 Gap_junction_hsa04540 3 88 0.1135 0.3347
18 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.1159 0.3347
19 Rap1_signaling_pathway_hsa04015 5 206 0.1424 0.3896
20 VEGF_signaling_pathway_hsa04370 2 59 0.1861 0.484
21 AMPK_signaling_pathway_hsa04152 3 121 0.2196 0.5438
22 FoxO_signaling_pathway_hsa04068 3 132 0.2586 0.6113
23 Cytokine_cytokine_receptor_interaction_hsa04060 5 270 0.2934 0.6184
24 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.3023 0.6184
25 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.3057 0.6184
26 TGF_beta_signaling_pathway_hsa04350 2 84 0.3092 0.6184
27 mTOR_signaling_pathway_hsa04150 3 151 0.3276 0.631
28 Cellular_senescence_hsa04218 3 160 0.3605 0.6694
29 Endocytosis_hsa04144 4 244 0.4109 0.7369
30 Sphingolipid_signaling_pathway_hsa04071 2 118 0.4689 0.7865
31 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.5072 0.8062
32 Autophagy_animal_hsa04140 2 128 0.5117 0.8062
33 Necroptosis_hsa04217 2 164 0.646 0.921
34 Tight_junction_hsa04530 2 170 0.6653 0.921
35 Focal_adhesion_hsa04510 2 199 0.747 0.996

Quest ID: 86f6e7692fb65de40cc5cc5d05d8fd29