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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p AADAC 0.65 0 -1.53 0 MirTarget -0.77 0 NA
2 hsa-miR-17-5p AADAC 0.7 2.0E-5 -1.53 0 MirTarget -0.19 0.04679 NA
3 hsa-miR-93-5p AADAC 1.4 0 -1.53 0 MirTarget -0.44 6.0E-5 NA
4 hsa-miR-107 AADAT 0.24 0.01708 -3.7 0 miRanda -0.32 0.03948 NA
5 hsa-miR-17-5p AAK1 0.7 2.0E-5 0.62 0 TargetScan -0.11 0.0001 NA
6 hsa-miR-106b-5p ABCA1 0.65 0 -1.1 0 MirTarget; miRNATAP -0.19 0.00194 NA
7 hsa-miR-362-3p ABCA1 0.81 0 -1.1 0 miRanda -0.15 0.0028 NA
8 hsa-miR-93-5p ABCA1 1.4 0 -1.1 0 MirTarget; miRNATAP -0.2 5.0E-5 NA
9 hsa-miR-107 ABCC3 0.24 0.01708 -0.3 0.09738 miRanda; miRNATAP -0.27 0.00186 NA
10 hsa-miR-106b-5p ABHD2 0.65 0 -1.2 0 miRNATAP -0.46 0 NA
11 hsa-miR-107 ABHD2 0.24 0.01708 -1.2 0 PITA; miRanda; miRNATAP -0.15 0.04468 NA
12 hsa-miR-17-5p ABHD2 0.7 2.0E-5 -1.2 0 TargetScan; miRNATAP -0.33 0 NA
13 hsa-miR-20a-5p ABHD2 0.85 0 -1.2 0 miRNATAP -0.28 0 NA
14 hsa-miR-93-5p ABHD2 1.4 0 -1.2 0 miRNATAP -0.47 0 NA
15 hsa-miR-106b-5p ABHD5 0.65 0 -0.6 0 MirTarget -0.19 1.0E-5 NA
16 hsa-miR-17-5p ABHD5 0.7 2.0E-5 -0.6 0 MirTarget; TargetScan -0.15 0 NA
17 hsa-miR-20a-5p ABHD5 0.85 0 -0.6 0 MirTarget -0.12 1.0E-5 NA
18 hsa-miR-93-5p ABHD5 1.4 0 -0.6 0 MirTarget -0.21 0 NA
19 hsa-miR-107 ABI2 0.24 0.01708 0.14 0.17339 miRanda -0.26 0 NA
20 hsa-miR-107 ABI3BP 0.24 0.01708 -1.96 0 miRanda -0.49 0.00087 NA
21 hsa-miR-107 ABR 0.24 0.01708 -0.28 0.11187 miRanda -0.59 0 NA
22 hsa-miR-106b-5p ABTB2 0.65 0 -0.43 0.0031 miRNAWalker2 validate -0.25 5.0E-5 NA
23 hsa-miR-362-3p ACAD11 0.81 0 -1.86 0 miRanda -0.19 0.00359 NA
24 hsa-miR-17-5p ACBD5 0.7 2.0E-5 -0.75 0 TargetScan -0.23 0 NA
25 hsa-miR-107 ACE 0.24 0.01708 0.8 1.0E-5 mirMAP -0.29 0.00112 NA
26 hsa-miR-362-3p ACE2 0.81 0 -2.26 0 miRanda -0.37 0.03184 NA
27 hsa-miR-107 ACER2 0.24 0.01708 -1.22 0 miRanda -0.39 0.0004 NA
28 hsa-miR-17-5p ACER2 0.7 2.0E-5 -1.22 0 TargetScan -0.41 0 NA
29 hsa-miR-362-3p ACER2 0.81 0 -1.22 0 miRanda -0.32 8.0E-5 NA
30 hsa-miR-17-5p ACER3 0.7 2.0E-5 0.02 0.84604 mirMAP -0.1 0.00064 NA
31 hsa-miR-20a-5p ACER3 0.85 0 0.02 0.84604 mirMAP -0.12 2.0E-5 NA
32 hsa-miR-17-5p ACOT2 0.7 2.0E-5 -1.29 0 miRNAWalker2 validate -0.19 0.00011 NA
33 hsa-miR-106b-5p ACOX1 0.65 0 -1.16 0 mirMAP -0.51 0 NA
34 hsa-miR-15a-5p ACOX1 0.35 0.00077 -1.16 0 miRNATAP -0.3 2.0E-5 NA
35 hsa-miR-17-5p ACOX1 0.7 2.0E-5 -1.16 0 mirMAP -0.22 0 NA
36 hsa-miR-20a-5p ACOX1 0.85 0 -1.16 0 mirMAP -0.15 0.00046 NA
37 hsa-miR-93-5p ACOX1 1.4 0 -1.16 0 mirMAP -0.41 0 NA
38 hsa-miR-362-3p ACSF3 0.81 0 -0.71 0 miRanda -0.15 0.00333 NA
39 hsa-miR-106b-5p ACSL6 0.65 0 0.39 0.26458 mirMAP -0.64 2.0E-5 NA
40 hsa-miR-17-5p ACSL6 0.7 2.0E-5 0.39 0.26458 mirMAP -0.37 0.00035 NA
41 hsa-miR-20a-5p ACSL6 0.85 0 0.39 0.26458 mirMAP -0.21 0.03388 NA
42 hsa-miR-93-5p ACSL6 1.4 0 0.39 0.26458 mirMAP -0.25 0.04057 NA
43 hsa-miR-107 ACTG1 0.24 0.01708 -0.12 0.20938 miRanda; miRNATAP -0.12 0.01365 NA
44 hsa-miR-107 ACTG2 0.24 0.01708 2.03 0 miRanda -0.31 0.01939 NA
45 hsa-miR-502-3p ACTN1 0.66 0 -0.08 0.45151 PITA; miRNATAP -0.12 0.00611 NA
46 hsa-miR-107 ACTR2 0.24 0.01708 -0.11 0.12815 MirTarget; PITA; miRanda; miRNATAP -0.11 0.0018 NA
47 hsa-miR-106b-5p ACTR3C 0.65 0 -0.99 0 mirMAP -0.5 0 NA
48 hsa-miR-17-5p ACTR3C 0.7 2.0E-5 -0.99 0 mirMAP -0.25 0 NA
49 hsa-miR-20a-5p ACTR3C 0.85 0 -0.99 0 mirMAP -0.21 1.0E-5 NA
50 hsa-miR-93-5p ACTR3C 1.4 0 -0.99 0 mirMAP -0.34 0 NA
51 hsa-miR-107 ACVR1 0.24 0.01708 -0.44 1.0E-5 miRanda -0.2 5.0E-5 NA
52 hsa-miR-362-3p ACVR1 0.81 0 -0.44 1.0E-5 miRanda -0.16 1.0E-5 NA
53 hsa-miR-362-3p ACY1 0.81 0 -1.04 0 miRanda -0.16 0.00797 NA
54 hsa-miR-33a-3p ADAM12 -0.68 1.0E-5 0.93 0.0022 mirMAP -0.4 3.0E-5 NA
55 hsa-miR-33a-3p ADAM22 -0.68 1.0E-5 1.17 0.00038 MirTarget -0.4 0.00011 NA
56 hsa-miR-33a-3p ADAM28 -0.68 1.0E-5 -0.45 0.16409 mirMAP -0.35 0.00038 NA
57 hsa-miR-362-3p ADAM28 0.81 0 -0.45 0.16409 PITA -0.22 0.04793 NA
58 hsa-miR-17-5p ADAM9 0.7 2.0E-5 0.47 0.00581 TargetScan; miRNATAP -0.2 8.0E-5 NA
59 hsa-miR-20a-5p ADAM9 0.85 0 0.47 0.00581 miRNATAP -0.24 0 NA
60 hsa-miR-362-3p ADAM9 0.81 0 0.47 0.00581 miRanda -0.17 0.00612 NA
61 hsa-miR-107 ADAMTS1 0.24 0.01708 -1.85 0 miRanda -0.58 0 NA
62 hsa-miR-362-3p ADAMTS1 0.81 0 -1.85 0 miRanda -0.3 5.0E-5 NA
63 hsa-miR-362-3p ADAMTS13 0.81 0 -3.25 0 miRanda -0.26 0.00142 NA
64 hsa-miR-107 ADAMTS14 0.24 0.01708 1.08 2.0E-5 miRanda -0.31 0.01029 NA
65 hsa-miR-17-3p ADAMTS15 0.41 0.00422 -0.88 0.00206 MirTarget; miRNATAP -0.42 2.0E-5 NA
66 hsa-miR-107 ADAMTS3 0.24 0.01708 -0.43 0.16392 miRanda -0.85 0 NA
67 hsa-miR-15a-5p ADAMTS5 0.35 0.00077 -0.16 0.36499 miRNATAP -0.2 0.0134 NA
68 hsa-miR-17-5p ADAMTS5 0.7 2.0E-5 -0.16 0.36499 TargetScan -0.11 0.03358 NA
69 hsa-miR-20a-5p ADAMTS5 0.85 0 -0.16 0.36499 miRNATAP -0.16 0.00122 NA
70 hsa-miR-33a-3p ADAMTS5 -0.68 1.0E-5 -0.16 0.36499 mirMAP -0.18 0.00129 NA
71 hsa-miR-107 ADAMTS6 0.24 0.01708 0.7 0.00475 miRanda -0.52 1.0E-5 NA
72 hsa-miR-107 ADAMTS9 0.24 0.01708 0.8 0 miRanda -0.43 0 NA
73 hsa-miR-502-3p ADAMTS9 0.66 0 0.8 0 PITA -0.16 0.02653 NA
74 hsa-miR-107 ADAMTSL1 0.24 0.01708 -0.65 0.00587 miRanda -0.34 0.00255 NA
75 hsa-miR-17-3p ADAMTSL1 0.41 0.00422 -0.65 0.00587 mirMAP -0.33 3.0E-5 NA
76 hsa-miR-33a-3p ADAMTSL1 -0.68 1.0E-5 -0.65 0.00587 mirMAP -0.24 0.00119 NA
77 hsa-miR-362-3p ADAMTSL1 0.81 0 -0.65 0.00587 miRanda -0.21 0.00993 NA
78 hsa-miR-17-5p ADAMTSL2 0.7 2.0E-5 -2.68 0 TargetScan -0.28 0.00562 NA
79 hsa-miR-107 ADAMTSL3 0.24 0.01708 -1.86 0 MirTarget; PITA; miRanda; miRNATAP -0.48 0.00097 NA
80 hsa-miR-15a-5p ADAMTSL3 0.35 0.00077 -1.86 0 MirTarget -0.47 0.00098 NA
81 hsa-miR-107 ADAP2 0.24 0.01708 -0.82 0 miRanda -0.43 0 NA
82 hsa-miR-106b-5p ADARB1 0.65 0 -0.13 0.22208 MirTarget -0.22 0 NA
83 hsa-miR-17-5p ADARB1 0.7 2.0E-5 -0.13 0.22208 miRNAWalker2 validate; MirTarget -0.13 7.0E-5 NA
84 hsa-miR-20a-5p ADARB1 0.85 0 -0.13 0.22208 MirTarget -0.11 0.00024 NA
85 hsa-miR-93-5p ADARB1 1.4 0 -0.13 0.22208 miRNAWalker2 validate; MirTarget -0.21 0 NA
86 hsa-miR-106b-5p ADCY1 0.65 0 -2.7 0 mirMAP -0.54 0.00112 NA
87 hsa-miR-17-5p ADCY1 0.7 2.0E-5 -2.7 0 mirMAP -0.24 0.03129 NA
88 hsa-miR-362-3p ADCY1 0.81 0 -2.7 0 miRanda -0.27 0.04736 NA
89 hsa-miR-93-5p ADCY1 1.4 0 -2.7 0 mirMAP -0.65 0 NA
90 hsa-miR-107 ADCY4 0.24 0.01708 0.69 3.0E-5 miRanda -0.18 0.02297 NA
91 hsa-miR-15a-5p ADCY5 0.35 0.00077 -1.75 0 MirTarget; miRNATAP -0.63 5.0E-5 NA
92 hsa-miR-106b-5p ADCY9 0.65 0 -0.11 0.30518 mirMAP -0.23 0 NA
93 hsa-miR-17-5p ADCY9 0.7 2.0E-5 -0.11 0.30518 mirMAP -0.12 0.00011 NA
94 hsa-miR-93-5p ADCY9 1.4 0 -0.11 0.30518 mirMAP -0.14 0.0003 NA
95 hsa-miR-106b-5p ADH5 0.65 0 -0.53 0 miRNAWalker2 validate -0.27 0 NA
96 hsa-miR-17-5p ADIPOR2 0.7 2.0E-5 -0.68 0 TargetScan -0.13 8.0E-5 NA
97 hsa-miR-17-5p ADRA1B 0.7 2.0E-5 -2.34 0 TargetScan -0.56 0 NA
98 hsa-miR-106b-5p ADRA2A 0.65 0 -0.76 0.02558 miRNATAP -0.6 3.0E-5 NA
99 hsa-miR-20a-5p ADRA2A 0.85 0 -0.76 0.02558 miRNATAP -0.4 2.0E-5 NA
100 hsa-miR-362-3p ADRA2B 0.81 0 -2.44 0 PITA; miRanda -0.32 4.0E-5 NA
101 hsa-miR-362-3p ADRB1 0.81 0 -2.23 0 miRanda -0.26 0.02312 NA
102 hsa-miR-106b-5p AEN 0.65 0 0.28 0.01239 MirTarget -0.11 0.02721 NA
103 hsa-miR-17-5p AEN 0.7 2.0E-5 0.28 0.01239 MirTarget; TargetScan -0.11 0.00144 NA
104 hsa-miR-107 AFAP1L2 0.24 0.01708 -0.55 0.00077 miRanda -0.57 0 NA
105 hsa-miR-33a-3p AFAP1L2 -0.68 1.0E-5 -0.55 0.00077 MirTarget -0.23 1.0E-5 NA
106 hsa-miR-17-5p AFF1 0.7 2.0E-5 -0.71 0 TargetScan -0.14 3.0E-5 NA
107 hsa-miR-33a-3p AFF2 -0.68 1.0E-5 1.4 0.00046 mirMAP -0.26 0.03692 NA
108 hsa-miR-106b-5p AFF4 0.65 0 -0.64 0 miRNATAP -0.27 0 NA
109 hsa-miR-15a-5p AFF4 0.35 0.00077 -0.64 0 MirTarget; miRNATAP -0.18 5.0E-5 NA
110 hsa-miR-17-5p AFF4 0.7 2.0E-5 -0.64 0 TargetScan; miRNATAP -0.14 0 NA
111 hsa-miR-20a-5p AFF4 0.85 0 -0.64 0 miRNATAP -0.13 0 NA
112 hsa-miR-362-3p AFF4 0.81 0 -0.64 0 PITA -0.13 0.00017 NA
113 hsa-miR-502-3p AFF4 0.66 0 -0.64 0 MirTarget; miRNATAP -0.19 0 NA
114 hsa-miR-93-5p AFF4 1.4 0 -0.64 0 miRNATAP -0.27 0 NA
115 hsa-miR-106b-5p AGA 0.65 0 0.02 0.86356 MirTarget -0.17 0.00102 NA
116 hsa-miR-17-5p AGFG2 0.7 2.0E-5 -0.02 0.87061 TargetScan; miRNATAP -0.11 0.00181 NA
117 hsa-miR-107 AGTPBP1 0.24 0.01708 0.03 0.74364 miRanda -0.19 9.0E-5 NA
118 hsa-miR-502-3p AHCYL1 0.66 0 -0.28 0.00031 miRNATAP -0.12 0.00021 NA
119 hsa-miR-15a-5p AHCYL2 0.35 0.00077 -0.16 0.11457 miRNATAP -0.11 0.02413 NA
120 hsa-miR-502-3p AHR 0.66 0 -0.97 0 MirTarget; PITA; miRNATAP -0.34 0 NA
121 hsa-miR-17-5p AHRR 0.7 2.0E-5 0.37 0.09373 MirTarget; TargetScan -0.14 0.03047 NA
122 hsa-miR-20a-5p AHRR 0.85 0 0.37 0.09373 MirTarget -0.13 0.04288 NA
123 hsa-miR-106b-5p AKAP11 0.65 0 -0.7 0 miRNAWalker2 validate -0.25 0 NA
124 hsa-miR-17-5p AKAP11 0.7 2.0E-5 -0.7 0 MirTarget; TargetScan -0.19 0 NA
125 hsa-miR-362-3p AKAP11 0.81 0 -0.7 0 miRanda -0.22 0 NA
126 hsa-miR-93-5p AKAP11 1.4 0 -0.7 0 miRNAWalker2 validate -0.25 0 NA
127 hsa-miR-107 AKAP12 0.24 0.01708 -1.36 0 miRanda; miRNATAP -0.52 0.0001 NA
128 hsa-miR-106b-5p AKAP13 0.65 0 -0.32 0.00142 MirTarget; mirMAP; miRNATAP -0.23 0 NA
129 hsa-miR-17-5p AKAP13 0.7 2.0E-5 -0.32 0.00142 MirTarget; TargetScan; mirMAP; miRNATAP -0.16 0 NA
130 hsa-miR-20a-5p AKAP13 0.85 0 -0.32 0.00142 MirTarget; mirMAP; miRNATAP -0.12 1.0E-5 NA
131 hsa-miR-93-5p AKAP13 1.4 0 -0.32 0.00142 MirTarget; miRNATAP -0.26 0 NA
132 hsa-miR-362-3p AKAP7 0.81 0 -0.93 0 miRanda -0.25 1.0E-5 NA
133 hsa-miR-17-5p AKAP9 0.7 2.0E-5 -0.79 0 TargetScan -0.18 2.0E-5 NA
134 hsa-miR-15a-5p AKIRIN1 0.35 0.00077 -0.73 0 miRNATAP -0.14 0.0021 NA
135 hsa-miR-93-5p AKIRIN1 1.4 0 -0.73 0 mirMAP -0.14 2.0E-5 NA
136 hsa-miR-106b-5p AKT3 0.65 0 -0.66 0.00047 miRNATAP -0.26 0.00148 NA
137 hsa-miR-107 AKT3 0.24 0.01708 -0.66 0.00047 PITA; miRanda -0.6 0 NA
138 hsa-miR-15a-5p AKT3 0.35 0.00077 -0.66 0.00047 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.00291 NA
139 hsa-miR-17-3p AKT3 0.41 0.00422 -0.66 0.00047 miRNATAP -0.35 0 NA
140 hsa-miR-17-5p AKT3 0.7 2.0E-5 -0.66 0.00047 TargetScan; miRNATAP -0.29 0 NA
141 hsa-miR-20a-5p AKT3 0.85 0 -0.66 0.00047 miRNATAP -0.29 0 NA
142 hsa-miR-33a-3p AKT3 -0.68 1.0E-5 -0.66 0.00047 mirMAP -0.23 0.0001 NA
143 hsa-miR-362-3p AKT3 0.81 0 -0.66 0.00047 miRanda -0.22 0.00083 NA
144 hsa-miR-502-3p AKT3 0.66 0 -0.66 0.00047 miRNATAP -0.26 0.0008 NA
145 hsa-miR-93-5p AKT3 1.4 0 -0.66 0.00047 miRNATAP -0.28 1.0E-5 NA
146 hsa-miR-106b-5p AKTIP 0.65 0 -0.37 0.00054 MirTarget; miRNATAP -0.36 0 NA
147 hsa-miR-17-5p AKTIP 0.7 2.0E-5 -0.37 0.00054 MirTarget; TargetScan; miRNATAP -0.28 0 NA
148 hsa-miR-20a-5p AKTIP 0.85 0 -0.37 0.00054 MirTarget; miRNATAP -0.25 0 NA
149 hsa-miR-93-5p AKTIP 1.4 0 -0.37 0.00054 MirTarget; miRNATAP -0.29 0 NA
150 hsa-miR-362-3p ALCAM 0.81 0 0.24 0.05364 miRanda -0.21 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CARDIOVASCULAR SYSTEM DEVELOPMENT 215 788 5.155e-37 1.199e-33
2 CIRCULATORY SYSTEM DEVELOPMENT 215 788 5.155e-37 1.199e-33
3 TISSUE DEVELOPMENT 324 1518 2.205e-32 3.419e-29
4 REGULATION OF CELLULAR COMPONENT MOVEMENT 195 771 7.205e-29 8.381e-26
5 BIOLOGICAL ADHESION 236 1032 6.831e-28 6.357e-25
6 CELL DEVELOPMENT 296 1426 2.351e-27 1.823e-24
7 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 331 1672 9.016e-27 5.993e-24
8 LOCOMOTION 245 1114 2.56e-26 1.489e-23
9 VASCULATURE DEVELOPMENT 135 469 7.254e-26 3.75e-23
10 REGULATION OF CELL DIFFERENTIATION 299 1492 5.237e-25 2.437e-22
11 HEART DEVELOPMENT 132 466 1.351e-24 5.715e-22
12 NEUROGENESIS 283 1402 3.757e-24 1.457e-21
13 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 263 1275 7.478e-24 2.676e-21
14 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 222 1021 3.475e-23 1.155e-20
15 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 211 957 7.671e-23 2.38e-20
16 ORGAN MORPHOGENESIS 189 841 1.689e-21 4.913e-19
17 EPITHELIUM DEVELOPMENT 205 945 2.555e-21 6.993e-19
18 INTRACELLULAR SIGNAL TRANSDUCTION 297 1572 1.016e-20 2.627e-18
19 TISSUE MORPHOGENESIS 135 533 2.753e-20 6.742e-18
20 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 264 1360 4.667e-20 1.086e-17
21 CELL MOTILITY 184 835 5.711e-20 1.208e-17
22 LOCALIZATION OF CELL 184 835 5.711e-20 1.208e-17
23 BLOOD VESSEL MORPHOGENESIS 104 364 6.408e-20 1.265e-17
24 NEURON DIFFERENTIATION 190 874 6.522e-20 1.265e-17
25 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 129 513 3.773e-19 7.022e-17
26 NEGATIVE REGULATION OF CELL COMMUNICATION 236 1192 4.669e-19 8.355e-17
27 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 303 1656 5.342e-19 9.206e-17
28 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 227 1142 1.457e-18 2.421e-16
29 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 263 1395 3.125e-18 5.013e-16
30 CELLULAR COMPONENT MORPHOGENESIS 189 900 4.046e-18 6.275e-16
31 POSITIVE REGULATION OF RESPONSE TO STIMULUS 337 1929 6.668e-18 1.001e-15
32 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 322 1848 6.265e-17 9.109e-15
33 MORPHOGENESIS OF AN EPITHELIUM 104 400 9.744e-17 1.374e-14
34 REGULATION OF CELL PROLIFERATION 272 1496 1.057e-16 1.447e-14
35 REGULATION OF PHOSPHORUS METABOLIC PROCESS 289 1618 1.174e-16 1.561e-14
36 RESPONSE TO ENDOGENOUS STIMULUS 265 1450 1.429e-16 1.847e-14
37 POSITIVE REGULATION OF LOCOMOTION 107 420 1.639e-16 2.062e-14
38 REGULATION OF CELL DEVELOPMENT 174 836 2.333e-16 2.857e-14
39 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 200 1008 2.395e-16 2.858e-14
40 NEURON DEVELOPMENT 150 687 4.39e-16 5.106e-14
41 CELL CELL ADHESION 137 608 6.099e-16 6.922e-14
42 POSITIVE REGULATION OF CELL COMMUNICATION 274 1532 6.997e-16 7.752e-14
43 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 167 801 8.247e-16 8.924e-14
44 TUBE DEVELOPMENT 127 552 1.37e-15 1.417e-13
45 REGULATION OF CELL MORPHOGENESIS 127 552 1.37e-15 1.417e-13
46 POSITIVE REGULATION OF GENE EXPRESSION 300 1733 2.155e-15 2.18e-13
47 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 193 983 2.505e-15 2.48e-13
48 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 148 689 2.974e-15 2.883e-13
49 MUSCLE STRUCTURE DEVELOPMENT 106 432 3.585e-15 3.405e-13
50 POSITIVE REGULATION OF MOLECULAR FUNCTION 307 1791 3.694e-15 3.437e-13
51 CELL PROJECTION ORGANIZATION 180 902 4.813e-15 4.391e-13
52 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 308 1805 6.124e-15 5.479e-13
53 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 94 368 9.724e-15 8.537e-13
54 POSITIVE REGULATION OF CELL DIFFERENTIATION 167 823 1.072e-14 9.236e-13
55 NEURON PROJECTION DEVELOPMENT 123 545 1.742e-14 1.473e-12
56 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 193 1004 2.161e-14 1.796e-12
57 UROGENITAL SYSTEM DEVELOPMENT 81 299 2.205e-14 1.8e-12
58 NEURON PROJECTION MORPHOGENESIS 99 402 2.312e-14 1.855e-12
59 REGULATION OF CELL ADHESION 136 629 2.441e-14 1.925e-12
60 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 302 1784 3.384e-14 2.624e-12
61 REGULATION OF CELL DEATH 259 1472 3.529e-14 2.692e-12
62 EMBRYO DEVELOPMENT 176 894 3.603e-14 2.704e-12
63 REGULATION OF TRANSPORT 304 1804 4.972e-14 3.672e-12
64 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 196 1036 6.665e-14 4.771e-12
65 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 196 1036 6.665e-14 4.771e-12
66 REGULATION OF OSSIFICATION 57 178 8.064e-14 5.685e-12
67 TAXIS 108 464 8.59e-14 5.966e-12
68 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 325 1977 1.647e-13 1.115e-11
69 HEAD DEVELOPMENT 146 709 1.654e-13 1.115e-11
70 ANGIOGENESIS 78 293 1.823e-13 1.212e-11
71 POSITIVE REGULATION OF CATALYTIC ACTIVITY 262 1518 2.403e-13 1.559e-11
72 RESPONSE TO OXYGEN CONTAINING COMPOUND 243 1381 2.412e-13 1.559e-11
73 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 159 799 2.654e-13 1.691e-11
74 REGULATION OF NEURON DIFFERENTIATION 121 554 3.286e-13 2.066e-11
75 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 151 750 4.164e-13 2.584e-11
76 MUSCLE TISSUE DEVELOPMENT 74 275 4.231e-13 2.591e-11
77 IMMUNE SYSTEM PROCESS 324 1984 4.34e-13 2.623e-11
78 RESPONSE TO EXTERNAL STIMULUS 302 1821 4.706e-13 2.807e-11
79 CENTRAL NERVOUS SYSTEM DEVELOPMENT 169 872 4.89e-13 2.88e-11
80 REGULATION OF PROTEIN MODIFICATION PROCESS 286 1710 7.947e-13 4.622e-11
81 EXTRACELLULAR STRUCTURE ORGANIZATION 78 304 1.44e-12 8.272e-11
82 NEGATIVE REGULATION OF CELL PROLIFERATION 133 643 1.482e-12 8.408e-11
83 REGULATION OF KINASE ACTIVITY 153 776 1.642e-12 9.205e-11
84 CELL PART MORPHOGENESIS 131 633 2.111e-12 1.169e-10
85 HOMEOSTATIC PROCESS 233 1337 2.205e-12 1.207e-10
86 NEGATIVE REGULATION OF CELL DIFFERENTIATION 127 609 2.662e-12 1.44e-10
87 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 253 1492 4.624e-12 2.473e-10
88 NEURON PROJECTION GUIDANCE 59 205 4.902e-12 2.592e-10
89 RESPONSE TO GROWTH FACTOR 105 475 5.764e-12 3.014e-10
90 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 63 229 8.212e-12 4.246e-10
91 ACTIN FILAMENT BASED PROCESS 100 450 1.34e-11 6.85e-10
92 EMBRYONIC MORPHOGENESIS 114 539 1.417e-11 7.168e-10
93 GLAND DEVELOPMENT 91 395 1.436e-11 7.186e-10
94 CHEMICAL HOMEOSTASIS 164 874 1.666e-11 8.246e-10
95 REGULATION OF CELLULAR LOCALIZATION 221 1277 1.72e-11 8.425e-10
96 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 201 1135 1.928e-11 9.344e-10
97 REGULATION OF ANATOMICAL STRUCTURE SIZE 103 472 2.059e-11 9.777e-10
98 TELENCEPHALON DEVELOPMENT 62 228 2.057e-11 9.777e-10
99 HEART MORPHOGENESIS 59 212 2.245e-11 1.055e-09
100 RESPONSE TO WOUNDING 117 563 2.485e-11 1.156e-09
101 GLAND MORPHOGENESIS 36 97 2.632e-11 1.212e-09
102 TUBE MORPHOGENESIS 78 323 3.727e-11 1.7e-09
103 REGULATION OF CELL PROJECTION ORGANIZATION 115 558 6.348e-11 2.868e-09
104 STEM CELL DIFFERENTIATION 54 190 6.574e-11 2.941e-09
105 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 96 437 6.768e-11 2.999e-09
106 FOREBRAIN DEVELOPMENT 83 357 6.965e-11 3.057e-09
107 CARDIAC CHAMBER DEVELOPMENT 45 144 8.205e-11 3.568e-09
108 SINGLE ORGANISM CELL ADHESION 99 459 1.013e-10 4.366e-09
109 NEGATIVE REGULATION OF PHOSPHORYLATION 93 422 1.124e-10 4.797e-09
110 REGULATION OF DEVELOPMENTAL GROWTH 71 289 1.229e-10 5.198e-09
111 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 69 278 1.381e-10 5.789e-09
112 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 141 740 1.575e-10 6.541e-09
113 NEGATIVE REGULATION OF CELL DEATH 160 872 1.734e-10 7.141e-09
114 REGULATION OF MAPK CASCADE 129 660 1.772e-10 7.232e-09
115 PROTEIN PHOSPHORYLATION 170 944 2.054e-10 8.309e-09
116 MESENCHYME DEVELOPMENT 53 190 2.101e-10 8.429e-09
117 IMMUNE SYSTEM DEVELOPMENT 117 582 2.172e-10 8.639e-09
118 EPITHELIAL CELL DEVELOPMENT 52 186 2.842e-10 1.121e-08
119 MESENCHYMAL CELL DIFFERENTIATION 42 134 3.122e-10 1.221e-08
120 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 78 337 3.255e-10 1.262e-08
121 REGULATION OF EPITHELIAL CELL PROLIFERATION 69 285 4.421e-10 1.7e-08
122 POSITIVE REGULATION OF CELL DEVELOPMENT 99 472 5.108e-10 1.948e-08
123 SENSORY ORGAN DEVELOPMENT 102 493 6.182e-10 2.338e-08
124 REGULATION OF GTPASE ACTIVITY 129 673 6.557e-10 2.461e-08
125 REGULATION OF ACTIN FILAMENT BASED PROCESS 73 312 7.184e-10 2.674e-08
126 POSITIVE REGULATION OF KINASE ACTIVITY 100 482 7.791e-10 2.837e-08
127 SALIVARY GLAND DEVELOPMENT 18 32 7.748e-10 2.837e-08
128 EPITHELIAL CELL DIFFERENTIATION 102 495 7.805e-10 2.837e-08
129 EMBRYONIC ORGAN DEVELOPMENT 88 406 8.592e-10 3.099e-08
130 REGULATION OF HYDROLASE ACTIVITY 220 1327 1.065e-09 3.812e-08
131 REGULATION OF NEURON PROJECTION DEVELOPMENT 88 408 1.112e-09 3.949e-08
132 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 47 166 1.277e-09 4.502e-08
133 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 157 876 1.488e-09 5.206e-08
134 KIDNEY EPITHELIUM DEVELOPMENT 39 125 1.54e-09 5.349e-08
135 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 108 541 1.635e-09 5.594e-08
136 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 108 541 1.635e-09 5.594e-08
137 REGULATION OF CELLULAR COMPONENT BIOGENESIS 141 767 1.931e-09 6.558e-08
138 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 54 207 2.059e-09 6.941e-08
139 DEVELOPMENTAL GROWTH 75 333 2.59e-09 8.669e-08
140 REGULATION OF OSTEOBLAST DIFFERENTIATION 36 112 2.643e-09 8.785e-08
141 EXOCRINE SYSTEM DEVELOPMENT 21 45 2.782e-09 9.179e-08
142 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 27 70 2.929e-09 9.596e-08
143 SKELETAL SYSTEM DEVELOPMENT 94 455 3.149e-09 1.025e-07
144 REGULATION OF PROTEIN LOCALIZATION 166 950 3.344e-09 1.081e-07
145 ION HOMEOSTASIS 112 576 3.9e-09 1.252e-07
146 RESPONSE TO LIPID 157 888 3.968e-09 1.265e-07
147 CARDIAC MUSCLE TISSUE DEVELOPMENT 41 140 4.826e-09 1.517e-07
148 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 100 498 4.795e-09 1.517e-07
149 PHOSPHORYLATION 203 1228 6.318e-09 1.973e-07
150 RESPONSE TO ABIOTIC STIMULUS 175 1024 6.702e-09 2.079e-07
151 GROWTH 86 410 6.975e-09 2.149e-07
152 WOUND HEALING 95 470 8.258e-09 2.511e-07
153 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 95 470 8.258e-09 2.511e-07
154 POSITIVE REGULATION OF HYDROLASE ACTIVITY 158 905 8.646e-09 2.612e-07
155 REGULATION OF JNK CASCADE 44 159 9.165e-09 2.751e-07
156 NEGATIVE REGULATION OF LOCOMOTION 62 263 9.985e-09 2.978e-07
157 RESPONSE TO HORMONE 156 893 1.034e-08 3.064e-07
158 POSITIVE REGULATION OF NEURON DIFFERENTIATION 69 306 1.057e-08 3.113e-07
159 NEGATIVE REGULATION OF GENE EXPRESSION 237 1493 1.251e-08 3.66e-07
160 REGULATION OF SYSTEM PROCESS 100 507 1.258e-08 3.66e-07
161 REGULATION OF TRANSFERASE ACTIVITY 163 946 1.275e-08 3.686e-07
162 MUSCLE ORGAN DEVELOPMENT 64 277 1.333e-08 3.817e-07
163 REGULATION OF CYTOPLASMIC TRANSPORT 96 481 1.337e-08 3.817e-07
164 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 76 352 1.435e-08 4.071e-07
165 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 191 1152 1.46e-08 4.116e-07
166 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 89 437 1.681e-08 4.712e-07
167 MUSCLE CELL DIFFERENTIATION 57 237 1.828e-08 5.094e-07
168 REGULATION OF GROWTH 118 633 1.856e-08 5.142e-07
169 MESONEPHROS DEVELOPMENT 30 90 2.143e-08 5.9e-07
170 RESPONSE TO ORGANIC CYCLIC COMPOUND 158 917 2.156e-08 5.901e-07
171 REGULATION OF BODY FLUID LEVELS 99 506 2.272e-08 6.182e-07
172 REGULATION OF CELLULAR COMPONENT SIZE 73 337 2.388e-08 6.46e-07
173 REGULATION OF VASCULATURE DEVELOPMENT 56 233 2.492e-08 6.703e-07
174 CELL ACTIVATION 108 568 2.569e-08 6.871e-07
175 RESPONSE TO MECHANICAL STIMULUS 52 210 2.724e-08 7.242e-07
176 DIGESTIVE SYSTEM DEVELOPMENT 41 148 2.807e-08 7.42e-07
177 POSITIVE REGULATION OF CELL PROLIFERATION 143 814 3.032e-08 7.97e-07
178 NEGATIVE REGULATION OF CELL ADHESION 54 223 3.356e-08 8.774e-07
179 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 92 465 4.123e-08 1.072e-06
180 RESPONSE TO INORGANIC SUBSTANCE 94 479 4.422e-08 1.143e-06
181 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 32 103 4.945e-08 1.271e-06
182 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 49 197 5.835e-08 1.484e-06
183 RESPIRATORY SYSTEM DEVELOPMENT 49 197 5.835e-08 1.484e-06
184 BEHAVIOR 99 516 6.216e-08 1.572e-06
185 POSITIVE REGULATION OF OSSIFICATION 28 84 6.271e-08 1.577e-06
186 CARDIAC CHAMBER MORPHOGENESIS 32 104 6.378e-08 1.587e-06
187 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 32 104 6.378e-08 1.587e-06
188 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 31 99 6.509e-08 1.602e-06
189 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 31 99 6.509e-08 1.602e-06
190 EYE DEVELOPMENT 70 326 6.638e-08 1.626e-06
191 POSITIVE REGULATION OF MAPK CASCADE 92 470 6.949e-08 1.693e-06
192 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 157 926 7.058e-08 1.71e-06
193 NEURAL CREST CELL DIFFERENTIATION 26 75 7.483e-08 1.804e-06
194 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 236 1517 7.615e-08 1.817e-06
195 REGULATION OF INTRACELLULAR TRANSPORT 114 621 7.586e-08 1.817e-06
196 PALLIUM DEVELOPMENT 41 153 7.75e-08 1.84e-06
197 CELLULAR RESPONSE TO NITROGEN COMPOUND 97 505 7.975e-08 1.874e-06
198 DEVELOPMENTAL MATURATION 48 193 7.963e-08 1.874e-06
199 CARDIAC SEPTUM DEVELOPMENT 28 85 8.355e-08 1.954e-06
200 ENDOTHELIUM DEVELOPMENT 29 90 8.528e-08 1.984e-06
201 RESPONSE TO NITROGEN COMPOUND 147 859 1.046e-07 2.414e-06
202 CARDIAC VENTRICLE DEVELOPMENT 32 106 1.048e-07 2.414e-06
203 REGULATION OF EPITHELIAL CELL MIGRATION 43 166 1.085e-07 2.487e-06
204 CYTOSKELETON ORGANIZATION 144 838 1.097e-07 2.501e-06
205 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 16 33 1.114e-07 2.528e-06
206 REGULATION OF CELL SIZE 44 172 1.147e-07 2.59e-06
207 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 39 144 1.174e-07 2.639e-06
208 REGULATION OF VESICLE MEDIATED TRANSPORT 90 462 1.209e-07 2.692e-06
209 POSITIVE REGULATION OF CELL ADHESION 77 376 1.209e-07 2.692e-06
210 CELLULAR HOMEOSTASIS 121 676 1.273e-07 2.82e-06
211 MORPHOGENESIS OF A BRANCHING STRUCTURE 43 167 1.304e-07 2.876e-06
212 REGULATION OF CELL SUBSTRATE ADHESION 44 173 1.372e-07 3.012e-06
213 REGULATION OF CELLULAR PROTEIN LOCALIZATION 103 552 1.423e-07 3.108e-06
214 RESPONSE TO OXIDATIVE STRESS 73 352 1.52e-07 3.306e-06
215 CELL JUNCTION ASSEMBLY 36 129 1.577e-07 3.413e-06
216 NEGATIVE REGULATION OF CELL DEVELOPMENT 65 303 2.005e-07 4.319e-06
217 VESICLE MEDIATED TRANSPORT 197 1239 2.095e-07 4.493e-06
218 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 14 27 2.411e-07 5.145e-06
219 LEUKOCYTE DIFFERENTIATION 63 292 2.479e-07 5.268e-06
220 NEPHRON DEVELOPMENT 33 115 2.515e-07 5.319e-06
221 CELLULAR RESPONSE TO HORMONE STIMULUS 102 552 2.659e-07 5.597e-06
222 REGULATION OF IMMUNE SYSTEM PROCESS 218 1403 2.752e-07 5.768e-06
223 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 34 121 2.888e-07 6.025e-06
224 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 111 616 2.989e-07 6.209e-06
225 NEGATIVE CHEMOTAXIS 17 39 3.108e-07 6.427e-06
226 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 102 554 3.178e-07 6.543e-06
227 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 45 184 3.355e-07 6.877e-06
228 CELL DEATH 164 1001 3.519e-07 7.181e-06
229 TRANSITION METAL ION HOMEOSTASIS 31 106 3.624e-07 7.363e-06
230 STRIATED MUSCLE CELL DIFFERENTIATION 43 173 3.771e-07 7.628e-06
231 BONE DEVELOPMENT 40 156 3.973e-07 7.969e-06
232 CELL JUNCTION ORGANIZATION 45 185 3.957e-07 7.969e-06
233 REGULATION OF HOMEOSTATIC PROCESS 86 447 4.002e-07 7.993e-06
234 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 162 4.168e-07 8.287e-06
235 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 64 303 4.437e-07 8.785e-06
236 REGULATION OF CHEMOTAXIS 44 180 4.578e-07 9.026e-06
237 LEUKOCYTE MIGRATION 57 259 4.602e-07 9.036e-06
238 POSITIVE REGULATION OF CATABOLIC PROCESS 78 395 4.725e-07 9.237e-06
239 APPENDAGE DEVELOPMENT 42 169 5.147e-07 9.979e-06
240 LIMB DEVELOPMENT 42 169 5.147e-07 9.979e-06
241 SMOOTH MUSCLE TISSUE DEVELOPMENT 11 18 5.339e-07 1.03e-05
242 CELL GROWTH 36 135 5.357e-07 1.03e-05
243 LOCOMOTORY BEHAVIOR 44 181 5.399e-07 1.034e-05
244 REGULATION OF ORGAN MORPHOGENESIS 54 242 5.778e-07 1.102e-05
245 SINGLE ORGANISM BEHAVIOR 76 384 6.02e-07 1.143e-05
246 REGULATION OF METAL ION TRANSPORT 67 325 6.098e-07 1.153e-05
247 POSITIVE REGULATION OF TRANSPORT 154 936 6.263e-07 1.18e-05
248 REGULATION OF MAP KINASE ACTIVITY 66 319 6.451e-07 1.21e-05
249 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 39 153 6.497e-07 1.214e-05
250 CELLULAR CHEMICAL HOMEOSTASIS 103 570 6.959e-07 1.295e-05
251 VENTRICULAR SEPTUM DEVELOPMENT 20 54 7.005e-07 1.299e-05
252 REGULATION OF PROTEIN IMPORT 44 183 7.467e-07 1.379e-05
253 MYELOID CELL DIFFERENTIATION 45 189 7.526e-07 1.384e-05
254 AMEBOIDAL TYPE CELL MIGRATION 39 154 7.768e-07 1.423e-05
255 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 52 232 8.037e-07 1.467e-05
256 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 61 289 8.393e-07 1.525e-05
257 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 12 22 8.727e-07 1.58e-05
258 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 45 190 8.801e-07 1.587e-05
259 PLASMA MEMBRANE ORGANIZATION 47 203 1.016e-06 1.826e-05
260 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 35 133 1.074e-06 1.923e-05
261 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 33 122 1.108e-06 1.968e-05
262 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 28 95 1.104e-06 1.968e-05
263 REGULATION OF CELL SHAPE 36 139 1.147e-06 2.029e-05
264 HEMOSTASIS 64 311 1.151e-06 2.029e-05
265 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 47 204 1.179e-06 2.069e-05
266 COLLAGEN FIBRIL ORGANIZATION 16 38 1.223e-06 2.131e-05
267 POSITIVE REGULATION OF CELL DEATH 107 605 1.222e-06 2.131e-05
268 RESPONSE TO FLUID SHEAR STRESS 15 34 1.282e-06 2.217e-05
269 CAMP METABOLIC PROCESS 15 34 1.282e-06 2.217e-05
270 GLIOGENESIS 42 175 1.389e-06 2.394e-05
271 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 49 218 1.514e-06 2.599e-05
272 REGULATION OF LIPID METABOLIC PROCESS 59 282 1.704e-06 2.914e-05
273 REGULATION OF BLOOD CIRCULATION 61 295 1.722e-06 2.935e-05
274 RESPONSE TO STEROID HORMONE 91 497 1.736e-06 2.948e-05
275 PROTEIN LOCALIZATION 265 1805 1.761e-06 2.98e-05
276 REGULATION OF LEUKOCYTE DIFFERENTIATION 51 232 1.878e-06 3.159e-05
277 REGULATION OF MUSCLE SYSTEM PROCESS 45 195 1.88e-06 3.159e-05
278 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 22 67 2.115e-06 3.528e-05
279 REGULATION OF BMP SIGNALING PATHWAY 24 77 2.123e-06 3.528e-05
280 DEVELOPMENTAL CELL GROWTH 24 77 2.123e-06 3.528e-05
281 ENDOTHELIAL CELL DIFFERENTIATION 23 72 2.143e-06 3.548e-05
282 PROTEIN DEPHOSPHORYLATION 44 190 2.205e-06 3.638e-05
283 REGULATION OF RESPONSE TO STRESS 221 1468 2.416e-06 3.973e-05
284 RESPONSE TO REACTIVE OXYGEN SPECIES 44 191 2.557e-06 4.19e-05
285 ACTIVATION OF PROTEIN KINASE ACTIVITY 58 279 2.57e-06 4.196e-05
286 REGULATION OF CELL JUNCTION ASSEMBLY 22 68 2.797e-06 4.551e-05
287 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 122 724 2.848e-06 4.618e-05
288 GLOMERULUS DEVELOPMENT 18 49 2.877e-06 4.649e-05
289 POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 12 24 2.939e-06 4.716e-05
290 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 12 24 2.939e-06 4.716e-05
291 REGULATION OF HEMOPOIESIS 63 314 3.371e-06 5.39e-05
292 VASCULOGENESIS 20 59 3.493e-06 5.566e-05
293 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 34 134 3.693e-06 5.864e-05
294 NEGATIVE REGULATION OF KINASE ACTIVITY 53 250 3.744e-06 5.926e-05
295 POSITIVE REGULATION OF GROWTH 51 238 4.103e-06 6.471e-05
296 POSITIVE REGULATION OF MAP KINASE ACTIVITY 46 207 4.327e-06 6.802e-05
297 CELL PROLIFERATION 114 672 4.367e-06 6.841e-05
298 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 23 75 4.683e-06 7.297e-05
299 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 20 60 4.689e-06 7.297e-05
300 ENDOCYTOSIS 91 509 4.811e-06 7.437e-05
301 INOSITOL LIPID MEDIATED SIGNALING 32 124 4.797e-06 7.437e-05
302 RHYTHMIC PROCESS 60 298 5.087e-06 7.837e-05
303 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 28 102 5.157e-06 7.919e-05
304 REGULATION OF RESPONSE TO WOUNDING 77 413 5.401e-06 8.267e-05
305 NEURAL CREST CELL MIGRATION 18 51 5.57e-06 8.497e-05
306 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 37 154 5.601e-06 8.517e-05
307 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 29 108 5.68e-06 8.608e-05
308 CIRCULATORY SYSTEM PROCESS 70 366 5.789e-06 8.746e-05
309 CELL MATURATION 33 131 6.026e-06 9.074e-05
310 REPRODUCTIVE SYSTEM DEVELOPMENT 76 408 6.41e-06 9.622e-05
311 REGULATION OF PROTEIN TARGETING 61 307 6.604e-06 9.88e-05
312 CELLULAR RESPONSE TO LIPID 83 457 6.736e-06 0.0001005
313 KIDNEY MORPHOGENESIS 24 82 7.227e-06 0.0001074
314 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 54 262 7.304e-06 0.0001082
315 NEGATIVE REGULATION OF TRANSPORT 83 458 7.338e-06 0.0001082
316 ENDOMEMBRANE SYSTEM ORGANIZATION 84 465 7.348e-06 0.0001082
317 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 30 115 7.432e-06 0.0001091
318 CYCLIC NUCLEOTIDE METABOLIC PROCESS 19 57 8.067e-06 0.000118
319 FOREBRAIN CELL MIGRATION 20 62 8.248e-06 0.0001203
320 REGULATION OF STEM CELL PROLIFERATION 25 88 8.414e-06 0.0001223
321 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 139 867 8.925e-06 0.0001294
322 PROTEIN LOCALIZATION TO CELL PERIPHERY 36 151 8.969e-06 0.0001296
323 CELLULAR RESPONSE TO EXTERNAL STIMULUS 54 264 9.202e-06 0.0001322
324 OSSIFICATION 52 251 9.186e-06 0.0001322
325 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 168 1087 9.432e-06 0.000135
326 DIGESTIVE TRACT MORPHOGENESIS 17 48 9.575e-06 0.0001367
327 TRABECULA MORPHOGENESIS 15 39 1.004e-05 0.0001428
328 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 18 53 1.034e-05 0.0001463
329 MESONEPHRIC TUBULE MORPHOGENESIS 18 53 1.034e-05 0.0001463
330 CELL SUBSTRATE ADHESION 38 164 1.041e-05 0.0001468
331 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 47 220 1.046e-05 0.0001471
332 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 27 100 1.055e-05 0.0001479
333 REGULATION OF OSTEOCLAST DIFFERENTIATION 20 63 1.082e-05 0.0001511
334 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 24 84 1.138e-05 0.0001581
335 EMBRYONIC ORGAN MORPHOGENESIS 56 279 1.138e-05 0.0001581
336 REGULATION OF ION TRANSPORT 101 592 1.191e-05 0.000165
337 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 71 381 1.256e-05 0.0001735
338 REGULATION OF EXTENT OF CELL GROWTH 27 101 1.288e-05 0.0001773
339 REGULATION OF CALCIUM ION TRANSPORT 45 209 1.296e-05 0.0001774
340 REGULATION OF CELL MATRIX ADHESION 25 90 1.295e-05 0.0001774
341 CARDIAC MUSCLE CELL DIFFERENTIATION 22 74 1.304e-05 0.000178
342 CELLULAR RESPONSE TO PEPTIDE 55 274 1.355e-05 0.0001843
343 PLATELET ACTIVATION 34 142 1.426e-05 0.0001935
344 MAMMARY GLAND MORPHOGENESIS 15 40 1.44e-05 0.0001942
345 CARDIOCYTE DIFFERENTIATION 26 96 1.439e-05 0.0001942
346 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 74 404 1.544e-05 0.0002077
347 BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS 9 16 1.55e-05 0.0002079
348 APOPTOTIC SIGNALING PATHWAY 57 289 1.638e-05 0.0002183
349 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 32 131 1.634e-05 0.0002183
350 ARTERY DEVELOPMENT 22 75 1.651e-05 0.0002196
351 REGULATION OF MEMBRANE POTENTIAL 65 343 1.666e-05 0.0002208
352 REGULATION OF SECRETION 115 699 1.672e-05 0.000221
353 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 58 296 1.696e-05 0.0002236
354 SEMAPHORIN PLEXIN SIGNALING PATHWAY 14 36 1.707e-05 0.0002244
355 POSITIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 17 50 1.782e-05 0.0002336
356 REGULATION OF DENDRITE DEVELOPMENT 30 120 1.837e-05 0.0002401
357 WNT SIGNALING PATHWAY 66 351 1.864e-05 0.0002426
358 REGULATION OF AXONOGENESIS 38 168 1.866e-05 0.0002426
359 METANEPHROS DEVELOPMENT 23 81 1.923e-05 0.0002492
360 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 36 156 1.931e-05 0.0002496
361 RESPONSE TO HYDROGEN PEROXIDE 28 109 2.014e-05 0.0002596
362 LUNG ALVEOLUS DEVELOPMENT 15 41 2.035e-05 0.0002616
363 RESPONSE TO CALCIUM ION 29 115 2.11e-05 0.0002704
364 REGULATION OF CELL CELL ADHESION 70 380 2.14e-05 0.0002736
365 RIBONUCLEOTIDE CATABOLIC PROCESS 12 28 2.147e-05 0.0002736
366 CONNECTIVE TISSUE DEVELOPMENT 42 194 2.16e-05 0.0002746
367 SENSORY ORGAN MORPHOGENESIS 49 239 2.193e-05 0.000278
368 POSITIVE REGULATION OF HEMOPOIESIS 37 163 2.199e-05 0.000278
369 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 103 616 2.323e-05 0.000293
370 RESPONSE TO METAL ION 63 333 2.352e-05 0.0002958
371 NEPHRON EPITHELIUM DEVELOPMENT 25 93 2.399e-05 0.0003008
372 NEURON MIGRATION 28 110 2.416e-05 0.0003021
373 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 32 134 2.663e-05 0.0003321
374 CEREBRAL CORTEX DEVELOPMENT 27 105 2.757e-05 0.000343
375 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 15 42 2.838e-05 0.0003521
376 CYCLIC NUCLEOTIDE CATABOLIC PROCESS 9 17 2.965e-05 0.0003659
377 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 9 17 2.965e-05 0.0003659
378 MAMMARY GLAND DEVELOPMENT 29 117 2.988e-05 0.0003678
379 LEUKOCYTE CELL CELL ADHESION 51 255 3.033e-05 0.0003715
380 CELLULAR RESPONSE TO OXIDATIVE STRESS 40 184 3.034e-05 0.0003715
381 NEGATIVE REGULATION OF MOLECULAR FUNCTION 164 1079 3.048e-05 0.0003722
382 TUBE FORMATION 31 129 3.101e-05 0.0003767
383 CELLULAR MACROMOLECULE LOCALIZATION 184 1234 3.099e-05 0.0003767
384 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 32 135 3.118e-05 0.0003779
385 DIVALENT INORGANIC CATION HOMEOSTASIS 64 343 3.165e-05 0.0003825
386 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 41 191 3.315e-05 0.0003996
387 REGULATION OF PEPTIDE TRANSPORT 51 256 3.381e-05 0.0004065
388 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 52 263 3.519e-05 0.0004209
389 REGULATION OF WNT SIGNALING PATHWAY 59 310 3.517e-05 0.0004209
390 LEUKOCYTE ACTIVATION 74 414 3.619e-05 0.0004318
391 GLIAL CELL DIFFERENTIATION 32 136 3.644e-05 0.0004325
392 EYE MORPHOGENESIS 32 136 3.644e-05 0.0004325
393 ORGAN GROWTH 20 68 3.784e-05 0.0004468
394 NERVE DEVELOPMENT 20 68 3.784e-05 0.0004468
395 RESPONSE TO OXYGEN LEVELS 59 311 3.873e-05 0.0004563
396 RESPONSE TO ESTROGEN 45 218 3.911e-05 0.0004596
397 POSITIVE REGULATION OF JUN KINASE ACTIVITY 19 63 3.999e-05 0.0004687
398 METANEPHRIC MESENCHYME DEVELOPMENT 8 14 4.068e-05 0.0004743
399 CAMP CATABOLIC PROCESS 8 14 4.068e-05 0.0004743
400 MAMMARY GLAND EPITHELIUM DEVELOPMENT 17 53 4.205e-05 0.0004892
401 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 31 131 4.26e-05 0.0004944
402 RESPONSE TO CYTOKINE 115 714 4.304e-05 0.0004982
403 REGULATION OF DENDRITE MORPHOGENESIS 21 74 4.407e-05 0.0005088
404 CELL CHEMOTAXIS 36 162 4.554e-05 0.0005245
405 RESPONSE TO DRUG 76 431 4.575e-05 0.0005257
406 NEGATIVE REGULATION OF OSSIFICATION 20 69 4.77e-05 0.0005467
407 REGULATION OF ENDOTHELIAL CELL MIGRATION 28 114 4.848e-05 0.0005543
408 REGULATION OF AXON GUIDANCE 14 39 4.894e-05 0.0005568
409 REGULATION OF CATABOLIC PROCESS 117 731 4.883e-05 0.0005568
410 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 83 482 4.985e-05 0.0005657
411 RESPONSE TO ALCOHOL 66 362 5.038e-05 0.0005704
412 RESPONSE TO PEPTIDE 72 404 5.054e-05 0.0005708
413 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 15 44 5.316e-05 0.0005989
414 LYMPHOCYTE ACTIVATION 63 342 5.4e-05 0.0006069
415 ALPHA BETA T CELL ACTIVATION 17 54 5.499e-05 0.0006165
416 REGULATION OF HEART CONTRACTION 45 221 5.531e-05 0.0006187
417 REGULATION OF CELL ACTIVATION 83 484 5.781e-05 0.0006451
418 REGULATION OF MYELOID CELL DIFFERENTIATION 39 183 6.022e-05 0.0006703
419 REGULATION OF JUN KINASE ACTIVITY 22 81 6.106e-05 0.0006781
420 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 25 98 6.207e-05 0.000686
421 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 25 98 6.207e-05 0.000686
422 INTRINSIC APOPTOTIC SIGNALING PATHWAY 34 152 6.36e-05 0.0007012
423 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 26 104 6.461e-05 0.0007107
424 SECRETION BY CELL 83 486 6.693e-05 0.0007345
425 REGULATION OF SMOOTH MUSCLE CONTRACTION 18 60 6.844e-05 0.0007493
426 REGULATION OF BINDING 54 283 6.879e-05 0.0007514
427 ALPHA BETA T CELL DIFFERENTIATION 15 45 7.15e-05 0.0007773
428 SPROUTING ANGIOGENESIS 15 45 7.15e-05 0.0007773
429 REGULATION OF ADHERENS JUNCTION ORGANIZATION 16 50 7.254e-05 0.0007868
430 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 34 153 7.306e-05 0.0007906
431 IN UTERO EMBRYONIC DEVELOPMENT 58 311 7.37e-05 0.0007957
432 REGULATION OF CYTOSKELETON ORGANIZATION 85 502 7.486e-05 0.0008064
433 REGULATION OF MUSCLE CONTRACTION 33 147 7.511e-05 0.0008072
434 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 32 141 7.686e-05 0.0008241
435 MESENCHYMAL TO EPITHELIAL TRANSITION 8 15 7.855e-05 0.0008382
436 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 27 111 7.848e-05 0.0008382
437 REGULATION OF RECEPTOR ACTIVITY 28 117 7.938e-05 0.0008452
438 T CELL DIFFERENTIATION 29 123 7.958e-05 0.0008454
439 REGULATION OF MULTICELLULAR ORGANISM GROWTH 19 66 8.105e-05 0.0008591
440 HIPPO SIGNALING 11 27 8.327e-05 0.00088
441 CELLULAR TRANSITION METAL ION HOMEOSTASIS 21 77 8.341e-05 0.00088
442 CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 13 36 8.453e-05 0.0008897
443 ACTION POTENTIAL 24 94 8.509e-05 0.0008897
444 RESPONSE TO BMP 24 94 8.509e-05 0.0008897
445 CELLULAR RESPONSE TO BMP STIMULUS 24 94 8.509e-05 0.0008897
446 REGULATION OF PROTEIN TYROSINE KINASE ACTIVITY 18 61 8.698e-05 0.0009054
447 POSITIVE REGULATION OF STEM CELL PROLIFERATION 18 61 8.698e-05 0.0009054
448 PEPTIDYL TYROSINE MODIFICATION 39 186 8.731e-05 0.0009069
449 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 25 100 8.859e-05 0.000916
450 LIMBIC SYSTEM DEVELOPMENT 25 100 8.859e-05 0.000916
451 ADRENAL GLAND DEVELOPMENT 10 23 9.106e-05 0.0009354
452 PROTEIN TARGETING TO PLASMA MEMBRANE 10 23 9.106e-05 0.0009354
453 TRABECULA FORMATION 10 23 9.106e-05 0.0009354
454 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 14 41 9.202e-05 0.000941
455 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 14 41 9.202e-05 0.000941
456 POST EMBRYONIC DEVELOPMENT 23 89 9.71e-05 0.0009908
457 REGULATION OF CELL GROWTH 69 391 9.785e-05 0.0009963
458 LIPID METABOLIC PROCESS 171 1158 9.925e-05 0.001008
459 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 24 95 0.0001019 0.001033
460 CIRCADIAN RHYTHM 31 137 0.0001046 0.001059
461 SECRETION 96 588 0.0001088 0.001096
462 REGULATION OF STEM CELL DIFFERENTIATION 27 113 0.0001087 0.001096
463 SKELETAL SYSTEM MORPHOGENESIS 41 201 0.0001112 0.001117
464 ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 23 90 0.0001167 0.00117
465 IMPORT INTO CELL 13 37 0.000117 0.00117
466 EAR DEVELOPMENT 40 195 0.000118 0.001178
467 MUSCLE SYSTEM PROCESS 53 282 0.0001201 0.001196
468 MYELOID LEUKOCYTE DIFFERENTIATION 24 96 0.0001215 0.001208
469 EPITHELIAL CELL MORPHOGENESIS 14 42 0.0001238 0.001229
470 REGULATION OF WOUND HEALING 29 126 0.0001256 0.001243
471 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 42 209 0.0001308 0.00129
472 LYMPHOCYTE DIFFERENTIATION 42 209 0.0001308 0.00129
473 NEGATIVE REGULATION OF MAPK CASCADE 32 145 0.0001346 0.001324
474 NEGATIVE REGULATION OF GROWTH 46 236 0.0001372 0.001347
475 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 20 74 0.0001398 0.00137
476 REGULATION OF DEVELOPMENTAL PIGMENTATION 8 16 0.0001416 0.001384
477 REGULATION OF PROTEIN SECRETION 68 389 0.0001463 0.001424
478 NEGATIVE REGULATION OF JNK CASCADE 12 33 0.0001462 0.001424
479 REGULATION OF MUSCLE TISSUE DEVELOPMENT 25 103 0.0001474 0.001429
480 REGULATION OF MUSCLE ORGAN DEVELOPMENT 25 103 0.0001474 0.001429
481 EMBRYONIC HEMOPOIESIS 9 20 0.0001494 0.001445
482 LIPID LOCALIZATION 50 264 0.0001516 0.001463
483 IRON ION HOMEOSTASIS 19 69 0.0001557 0.0015
484 REGULATION OF CELLULAR RESPONSE TO STRESS 109 691 0.0001569 0.001509
485 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 13 38 0.0001596 0.001531
486 COGNITION 48 251 0.0001602 0.001534
487 CELLULAR LIPID METABOLIC PROCESS 138 913 0.0001663 0.001589
488 POSITIVE REGULATION OF PROTEIN IMPORT 25 104 0.0001736 0.001656
489 FORMATION OF PRIMARY GERM LAYER 26 110 0.0001743 0.001659
490 CARTILAGE DEVELOPMENT 32 147 0.000176 0.001672
491 STEM CELL DIVISION 11 29 0.0001785 0.001685
492 REGULATION OF HOMOTYPIC CELL CELL ADHESION 56 307 0.0001779 0.001685
493 MEMBRANE ORGANIZATION 136 899 0.0001782 0.001685
494 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 21 81 0.0001828 0.001722
495 CARBOHYDRATE DERIVATIVE METABOLIC PROCESS 155 1047 0.0001854 0.001743
496 TISSUE REMODELING 22 87 0.0001919 0.001801
497 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 29 129 0.000194 0.001816
498 POSITIVE REGULATION OF CELL GROWTH 32 148 0.0002008 0.001872
499 RESPONSE TO TRANSITION METAL NANOPARTICLE 32 148 0.0002008 0.001872
500 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 51 274 0.0002042 0.0019
501 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 40 200 0.0002074 0.001926
502 CARDIAC SEPTUM MORPHOGENESIS 15 49 0.0002113 0.001959
503 ION TRANSPORT 182 1262 0.0002119 0.00196
504 INTEGRIN MEDIATED SIGNALING PATHWAY 21 82 0.00022 0.002031
505 MYELOID CELL HOMEOSTASIS 22 88 0.0002291 0.002111
506 REGULATION OF ION HOMEOSTASIS 40 201 0.0002313 0.002127
507 CHONDROCYTE DEVELOPMENT 9 21 0.0002355 0.002157
508 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 9 21 0.0002355 0.002157
509 CELLULAR RESPONSE TO OXYGEN LEVELS 31 143 0.0002384 0.002179
510 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 8 17 0.0002411 0.002187
511 MAMMARY GLAND ALVEOLUS DEVELOPMENT 8 17 0.0002411 0.002187
512 MAMMARY GLAND LOBULE DEVELOPMENT 8 17 0.0002411 0.002187
513 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 41 208 0.0002406 0.002187
514 SKELETAL MUSCLE ORGAN DEVELOPMENT 30 137 0.0002478 0.002243
515 CRANIAL SKELETAL SYSTEM DEVELOPMENT 16 55 0.0002539 0.002294
516 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 96 602 0.0002573 0.00232
517 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 18 66 0.0002621 0.00235
518 REGULATION OF VASOCONSTRICTION 18 66 0.0002621 0.00235
519 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 18 66 0.0002621 0.00235
520 POST GOLGI VESICLE MEDIATED TRANSPORT 21 83 0.0002637 0.00236
521 VASCULAR PROCESS IN CIRCULATORY SYSTEM 34 163 0.0002658 0.002374
522 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 45 236 0.00027 0.002405
523 CELL MATRIX ADHESION 27 119 0.0002707 0.002405
524 FACE DEVELOPMENT 15 50 0.0002708 0.002405
525 EPITHELIAL CELL PROLIFERATION 22 89 0.0002724 0.002415
526 CANONICAL WNT SIGNALING PATHWAY 23 95 0.0002775 0.002455
527 MAINTENANCE OF LOCATION 30 138 0.0002831 0.0025
528 RENAL TUBULE DEVELOPMENT 20 78 0.0003024 0.002665
529 ENTRAINMENT OF CIRCADIAN CLOCK 10 26 0.0003078 0.002702
530 HEART GROWTH 10 26 0.0003078 0.002702
531 POSITIVE REGULATION OF CHEMOTAXIS 27 120 0.0003124 0.002738
532 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 18 67 0.0003212 0.002809
533 REGULATION OF MUSCLE CELL DIFFERENTIATION 32 152 0.0003336 0.002907
534 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 32 152 0.0003336 0.002907
535 IMMUNE RESPONSE 160 1100 0.0003417 0.002972
536 REGULATION OF ORGAN GROWTH 19 73 0.0003451 0.002996
537 RESPONSE TO ESTRADIOL 31 146 0.0003506 0.003038
538 NEGATIVE REGULATION OF MUSCLE CONTRACTION 9 22 0.0003588 0.0031
539 CARDIAC VENTRICLE MORPHOGENESIS 17 62 0.0003591 0.0031
540 BONE MORPHOGENESIS 20 79 0.0003627 0.003125
541 CELLULAR RESPONSE TO ALCOHOL 26 115 0.0003693 0.003177
542 OLFACTORY LOBE DEVELOPMENT 12 36 0.000374 0.003204
543 CORTICAL CYTOSKELETON ORGANIZATION 12 36 0.000374 0.003204
544 CELL SUBSTRATE JUNCTION ASSEMBLY 13 41 0.0003759 0.003215
545 SMALL MOLECULE METABOLIC PROCESS 243 1767 0.0003842 0.003281
546 KIDNEY MESENCHYME DEVELOPMENT 8 18 0.0003913 0.003328
547 CENTROSOME LOCALIZATION 8 18 0.0003913 0.003328
548 SECOND MESSENGER MEDIATED SIGNALING 33 160 0.0004022 0.003415
549 DIVALENT INORGANIC CATION TRANSPORT 49 268 0.0004129 0.0035
550 NEGATIVE REGULATION OF SECRETION 39 200 0.0004216 0.003566
551 ADULT LOCOMOTORY BEHAVIOR 20 80 0.0004332 0.003658
552 MOTOR NEURON AXON GUIDANCE 10 27 0.0004398 0.003694
553 NEGATIVE REGULATION OF AXON GUIDANCE 10 27 0.0004398 0.003694
554 SUBSTRATE DEPENDENT CELL MIGRATION 10 27 0.0004398 0.003694
555 REGULATION OF HORMONE SECRETION 48 262 0.0004485 0.00376
556 MULTICELLULAR ORGANISMAL SIGNALING 27 123 0.0004738 0.003965
557 GASTRULATION 32 155 0.0004795 0.004006
558 METANEPHRIC NEPHRON DEVELOPMENT 11 32 0.0004837 0.004019
559 POSITIVE REGULATION OF DENDRITE MORPHOGENESIS 11 32 0.0004837 0.004019
560 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 11 32 0.0004837 0.004019
561 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 37 188 0.0004859 0.004031
562 SPECIFICATION OF SYMMETRY 26 117 0.00049 0.004042
563 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 26 117 0.00049 0.004042
564 AUTONOMIC NERVOUS SYSTEM DEVELOPMENT 13 42 0.0004889 0.004042
565 HOMEOSTASIS OF NUMBER OF CELLS 35 175 0.0004999 0.00411
566 POSITIVE REGULATION OF AUTOPHAGY 19 75 0.0004992 0.00411
567 NEURAL TUBE DEVELOPMENT 31 149 0.0005073 0.004156
568 REGULATION OF LEUKOCYTE MIGRATION 31 149 0.0005073 0.004156
569 ODONTOGENESIS 24 105 0.0005153 0.004214
570 MULTICELLULAR ORGANISM METABOLIC PROCESS 22 93 0.0005261 0.004295
571 CRANIAL NERVE MORPHOGENESIS 9 23 0.000531 0.004327
572 CELL PROJECTION ASSEMBLY 48 264 0.0005348 0.004348
573 RAS PROTEIN SIGNAL TRANSDUCTION 30 143 0.0005355 0.004348
574 NEURON PROJECTION EXTENSION 15 53 0.0005431 0.004402
575 URETER DEVELOPMENT 6 11 0.0005628 0.004531
576 NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 11 0.0005628 0.004531
577 REGULATION OF FEVER GENERATION 6 11 0.0005628 0.004531
578 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 105 684 0.000561 0.004531
579 LYSOSOMAL TRANSPORT 18 70 0.0005728 0.004603
580 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 14 48 0.0005904 0.004729
581 COLUMNAR CUBOIDAL EPITHELIAL CELL DEVELOPMENT 14 48 0.0005904 0.004729
582 REGULATION OF CALCIUM MEDIATED SIGNALING 19 76 0.0005964 0.004765
583 PROTEIN CATABOLIC PROCESS 91 579 0.000597 0.004765
584 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 30 144 0.0006049 0.00482
585 PEPTIDYL TYROSINE DEPHOSPHORYLATION 23 100 0.000608 0.004836
586 CELLULAR RESPONSE TO FLUID SHEAR STRESS 8 19 0.0006094 0.004839
587 VENTRICULAR SEPTUM MORPHOGENESIS 10 28 0.0006157 0.004856
588 REGULATION OF KERATINOCYTE PROLIFERATION 10 28 0.0006157 0.004856
589 RECEPTOR MEDIATED ENDOCYTOSIS 43 231 0.0006158 0.004856
590 MAMMARY GLAND DUCT MORPHOGENESIS 10 28 0.0006157 0.004856
591 CRANIAL NERVE DEVELOPMENT 13 43 0.0006294 0.004947
592 CEREBRAL CORTEX CELL MIGRATION 13 43 0.0006294 0.004947
593 SPHINGOLIPID METABOLIC PROCESS 29 138 0.0006382 0.004982
594 INTERFERON GAMMA PRODUCTION 7 15 0.0006402 0.004982
595 NEGATIVE REGULATION OF SMOOTH MUSCLE CONTRACTION 7 15 0.0006402 0.004982
596 POSITIVE REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 7 15 0.0006402 0.004982
597 VENOUS BLOOD VESSEL DEVELOPMENT 7 15 0.0006402 0.004982
598 AMINO ACID IMPORT 7 15 0.0006402 0.004982
599 ORGANOPHOSPHATE CATABOLIC PROCESS 25 113 0.0006674 0.005184
600 NEGATIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 24 107 0.000688 0.005335
601 CAMERA TYPE EYE MORPHOGENESIS 23 101 0.0007048 0.005448
602 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 27 126 0.0007041 0.005448
603 METAL ION TRANSPORT 91 582 0.0007066 0.005453
604 EMBRYONIC PLACENTA DEVELOPMENT 20 83 0.0007206 0.005542
605 PROTEOGLYCAN METABOLIC PROCESS 20 83 0.0007206 0.005542
606 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 31 152 0.0007229 0.00555
607 GLYCOPROTEIN METABOLIC PROCESS 60 353 0.0007266 0.005569
608 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 37 192 0.0007355 0.005629
609 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 16 60 0.0007408 0.005642
610 CHONDROCYTE DIFFERENTIATION 16 60 0.0007408 0.005642
611 MATERNAL PROCESS INVOLVED IN FEMALE PREGNANCY 16 60 0.0007408 0.005642
612 REGULATION OF HORMONE LEVELS 77 478 0.0007453 0.005667
613 REGULATION OF ENDOCYTOSIS 38 199 0.0007536 0.00572
614 POSITIVE REGULATION OF OSTEOCLAST DIFFERENTIATION 9 24 0.0007653 0.00579
615 REGULATION OF EMBRYONIC DEVELOPMENT 25 114 0.0007651 0.00579
616 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 40 213 0.0007827 0.005912
617 REGULATION OF EXOCYTOSIS 36 186 0.0007923 0.005946
618 NEGATIVE REGULATION OF PROTEIN SECRETION 24 108 0.0007919 0.005946
619 MESODERM MORPHOGENESIS 17 66 0.0007894 0.005946
620 MUCOPOLYSACCHARIDE METABOLIC PROCESS 24 108 0.0007919 0.005946
621 RESPONSE TO TOXIC SUBSTANCE 44 241 0.0008148 0.006086
622 NEGATIVE REGULATION OF HOMOTYPIC CELL CELL ADHESION 23 102 0.0008148 0.006086
623 RENAL SYSTEM PROCESS 23 102 0.0008148 0.006086
624 MAINTENANCE OF LOCATION IN CELL 22 96 0.0008327 0.006209
625 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 26 121 0.0008384 0.006242
626 NEGATIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 12 39 0.0008479 0.006272
627 REGULATION OF PHOSPHOLIPASE C ACTIVITY 12 39 0.0008479 0.006272
628 REGULATION OF VACUOLAR TRANSPORT 10 29 0.0008458 0.006272
629 ANATOMICAL STRUCTURE MATURATION 12 39 0.0008479 0.006272
630 ALCOHOL METABOLIC PROCESS 59 348 0.0008532 0.006301
631 ADHERENS JUNCTION ASSEMBLY 11 34 0.0008674 0.006386
632 RENAL WATER HOMEOSTASIS 11 34 0.0008674 0.006386
633 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 16 61 0.0009009 0.006622
634 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 27 128 0.0009073 0.006659
635 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 24 109 0.000909 0.006661
636 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 8 20 0.0009161 0.006677
637 INTRACELLULAR LIPID TRANSPORT 8 20 0.0009161 0.006677
638 ACTIN FILAMENT ORGANIZATION 34 174 0.000917 0.006677
639 LYMPH VESSEL DEVELOPMENT 8 20 0.0009161 0.006677
640 VISUAL BEHAVIOR 14 50 0.0009253 0.006717
641 PURINE CONTAINING COMPOUND CATABOLIC PROCESS 14 50 0.0009253 0.006717
642 REGULATION OF PROTEIN CATABOLIC PROCESS 65 393 0.0009361 0.006785
643 RESPONSE TO TEMPERATURE STIMULUS 30 148 0.000968 0.007005
644 POSITIVE REGULATION OF CELL CELL ADHESION 44 243 0.0009706 0.007012
645 HIPPOCAMPUS DEVELOPMENT 18 73 0.0009782 0.007056
646 ENSHEATHMENT OF NEURONS 21 91 0.000983 0.007069
647 AXON ENSHEATHMENT 21 91 0.000983 0.007069
648 VACUOLE ORGANIZATION 33 168 0.0009851 0.007073
649 DENDRITE DEVELOPMENT 19 79 0.0009921 0.007086
650 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 19 79 0.0009921 0.007086
651 PALATE DEVELOPMENT 20 85 0.0009929 0.007086
652 HEART PROCESS 20 85 0.0009929 0.007086
653 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 25 116 0.0009984 0.007114
654 L AMINO ACID IMPORT 6 12 0.001019 0.007194
655 REGULATION OF DENDRITIC SPINE DEVELOPMENT 15 56 0.001021 0.007194
656 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 15 56 0.001021 0.007194
657 OUTFLOW TRACT MORPHOGENESIS 15 56 0.001021 0.007194
658 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 6 12 0.001019 0.007194
659 CATABOLIC PROCESS 240 1773 0.001022 0.007194
660 EMBRYONIC CAMERA TYPE EYE FORMATION 6 12 0.001019 0.007194
661 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 6 12 0.001019 0.007194
662 DEPHOSPHORYLATION 50 286 0.001032 0.007253
663 POSITIVE REGULATION OF RESPONSE TO WOUNDING 32 162 0.001057 0.007418
664 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 9 25 0.001077 0.00755
665 RESPONSE TO CAMP 23 104 0.00108 0.007556
666 DEVELOPMENTAL PIGMENTATION 12 40 0.001089 0.007595
667 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 12 40 0.001089 0.007595
668 AMMONIUM ION METABOLIC PROCESS 33 169 0.001095 0.007613
669 REGULATION OF BLOOD PRESSURE 33 169 0.001095 0.007613
670 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 22 98 0.001114 0.007724
671 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 22 98 0.001114 0.007724
672 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 17 68 0.001134 0.007854
673 NEURON MATURATION 10 30 0.001142 0.00786
674 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 14 51 0.001145 0.00786
675 NEGATIVE REGULATION OF CHEMOTAXIS 14 51 0.001145 0.00786
676 REGULATION OF NEURON MIGRATION 10 30 0.001142 0.00786
677 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 21 92 0.001141 0.00786
678 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 10 30 0.001142 0.00786
679 ORGANOPHOSPHATE METABOLIC PROCESS 129 885 0.001152 0.007894
680 CELL CELL JUNCTION ASSEMBLY 18 74 0.001159 0.00793
681 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 19 80 0.001166 0.007956
682 CELLULAR RESPONSE TO MECHANICAL STIMULUS 19 80 0.001166 0.007956
683 REGULATION OF TRANSMEMBRANE TRANSPORT 69 426 0.001177 0.008019
684 HINDBRAIN DEVELOPMENT 28 137 0.001231 0.008372
685 CIRCADIAN REGULATION OF GENE EXPRESSION 15 57 0.001243 0.008444
686 EPIDERMIS DEVELOPMENT 45 253 0.00125 0.00848
687 CELLULAR COMPONENT ASSEMBLY INVOLVED IN MORPHOGENESIS 44 246 0.001253 0.008489
688 MEMBRANE LIPID METABOLIC PROCESS 35 184 0.001277 0.008634
689 MESODERM DEVELOPMENT 25 118 0.001291 0.008718
690 REGULATION OF CARTILAGE DEVELOPMENT 16 63 0.00131 0.008821
691 RESPONSE TO OSMOTIC STRESS 16 63 0.00131 0.008821
692 NEGATIVE REGULATION OF ORGAN GROWTH 8 21 0.001335 0.008963
693 ZINC ION HOMEOSTASIS 8 21 0.001335 0.008963
694 NUCLEOSIDE PHOSPHATE CATABOLIC PROCESS 17 69 0.00135 0.009025
695 PERIPHERAL NERVOUS SYSTEM DEVELOPMENT 17 69 0.00135 0.009025
696 POSITIVE REGULATION OF AXONOGENESIS 17 69 0.00135 0.009025
697 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 18 75 0.001367 0.009127
698 REGULATION OF LIPID STORAGE 12 41 0.001384 0.009172
699 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 12 41 0.001384 0.009172
700 NEGATIVE REGULATION OF CELL CELL ADHESION 28 138 0.001382 0.009172
701 AORTA DEVELOPMENT 12 41 0.001384 0.009172
702 PLACENTA DEVELOPMENT 28 138 0.001382 0.009172
703 REGULATION OF FAT CELL DIFFERENTIATION 23 106 0.001416 0.009374
704 PROTEIN AUTOPHOSPHORYLATION 36 192 0.001431 0.009461
705 SYNAPSE ORGANIZATION 29 145 0.001449 0.009561
706 POSITIVE REGULATION OF PROTEOLYSIS 60 363 0.001459 0.009618
707 REGULATION OF LEUKOCYTE PROLIFERATION 38 206 0.001465 0.009644
708 POSITIVE REGULATION OF AXON EXTENSION 11 36 0.001474 0.009672
709 HEAD MORPHOGENESIS 11 36 0.001474 0.009672
710 HEART TRABECULA MORPHOGENESIS 9 26 0.001485 0.009703
711 MESODERMAL CELL DIFFERENTIATION 9 26 0.001485 0.009703
712 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 9 26 0.001485 0.009703
713 ADULT WALKING BEHAVIOR 10 31 0.001518 0.009864
714 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 10 31 0.001518 0.009864
715 MATERNAL PLACENTA DEVELOPMENT 10 31 0.001518 0.009864
716 WALKING BEHAVIOR 10 31 0.001518 0.009864
717 NEURAL TUBE FORMATION 21 94 0.001523 0.009872
718 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 34 179 0.001523 0.009872
719 TRANSMEMBRANE TRANSPORT 155 1098 0.001541 0.009975
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 302 1737 9.426e-16 8.756e-13
2 CYTOSKELETAL PROTEIN BINDING 159 819 2.161e-12 1.004e-09
3 RECEPTOR BINDING 246 1476 5.7e-11 1.765e-08
4 CALCIUM ION BINDING 134 697 2.466e-10 4.581e-08
5 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 77 328 2.088e-10 4.581e-08
6 MOLECULAR FUNCTION REGULATOR 225 1353 5.084e-10 7.872e-08
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 73 315 1.127e-09 1.496e-07
8 ACTIN BINDING 83 393 9.179e-09 1.036e-06
9 MACROMOLECULAR COMPLEX BINDING 225 1399 1.004e-08 1.036e-06
10 SMAD BINDING 26 72 2.862e-08 2.078e-06
11 KINASE ACTIVITY 147 842 2.907e-08 2.078e-06
12 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 117 629 2.418e-08 2.078e-06
13 PROTEIN COMPLEX BINDING 160 935 2.807e-08 2.078e-06
14 PROTEIN KINASE ACTIVITY 118 640 3.496e-08 2.32e-06
15 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 54 226 5.429e-08 3.152e-06
16 PROTEIN DOMAIN SPECIFIC BINDING 115 624 5.353e-08 3.152e-06
17 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 27 81 1.073e-07 5.866e-06
18 REGULATORY REGION NUCLEIC ACID BINDING 141 818 1.235e-07 6.375e-06
19 CHEMOREPELLENT ACTIVITY 14 27 2.411e-07 1.179e-05
20 BINDING BRIDGING 43 173 3.771e-07 1.751e-05
21 KINASE BINDING 109 606 4.189e-07 1.769e-05
22 RIBONUCLEOTIDE BINDING 276 1860 4.181e-07 1.769e-05
23 GROWTH FACTOR BINDING 34 123 4.412e-07 1.782e-05
24 CELL ADHESION MOLECULE BINDING 45 186 4.658e-07 1.803e-05
25 TRANSCRIPTION FACTOR BINDING 96 524 8.84e-07 3.159e-05
26 RECEPTOR SIGNALING PROTEIN ACTIVITY 42 172 8.527e-07 3.159e-05
27 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 51 228 1.089e-06 3.747e-05
28 IDENTICAL PROTEIN BINDING 187 1209 2.762e-06 9.163e-05
29 PHOSPHOLIPID BINDING 70 360 3.183e-06 0.000102
30 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 21 64 3.633e-06 0.0001125
31 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 61 303 4.275e-06 0.0001241
32 ENZYME REGULATOR ACTIVITY 153 959 4.163e-06 0.0001241
33 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 157 992 4.946e-06 0.0001392
34 GLYCOSAMINOGLYCAN BINDING 45 205 7.676e-06 0.0002097
35 INTEGRIN BINDING 28 105 9.436e-06 0.0002505
36 RHO GTPASE BINDING 23 78 9.717e-06 0.0002507
37 ADENYL NUCLEOTIDE BINDING 222 1514 1.43e-05 0.0003591
38 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 63 329 1.597e-05 0.0003904
39 SH3 DOMAIN BINDING 29 116 2.514e-05 0.0005989
40 TRANSMEMBRANE RECEPTOR PROTEIN PHOSPHATASE ACTIVITY 9 17 2.965e-05 0.0006886
41 PROTEIN DIMERIZATION ACTIVITY 173 1149 3.14e-05 0.0006946
42 LIPID BINDING 108 657 3.107e-05 0.0006946
43 PHOSPHATIDYLINOSITOL BINDING 42 200 4.597e-05 0.0009932
44 SULFUR COMPOUND BINDING 47 234 5.46e-05 0.001153
45 CYTOKINE BINDING 24 92 5.874e-05 0.001213
46 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 38 178 7.153e-05 0.001445
47 X3 5 CYCLIC AMP PHOSPHODIESTERASE ACTIVITY 8 15 7.855e-05 0.00152
48 PROTEIN SERINE THREONINE KINASE ACTIVITY 77 445 7.805e-05 0.00152
49 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 73 417 8.121e-05 0.00154
50 KINASE REGULATOR ACTIVITY 39 186 8.731e-05 0.001622
51 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 73 420 0.0001024 0.001866
52 GTPASE BINDING 55 295 0.0001125 0.00201
53 PROTEIN COMPLEX SCAFFOLD 19 68 0.0001259 0.002089
54 PROTEIN TYROSINE KINASE ACTIVITY 37 176 0.0001235 0.002089
55 HEPARIN BINDING 34 157 0.000125 0.002089
56 HISTONE ACETYLTRANSFERASE BINDING 11 28 0.0001233 0.002089
57 DOUBLE STRANDED DNA BINDING 119 764 0.0001365 0.002224
58 GUANYL NUCLEOTIDE BINDING 68 390 0.0001581 0.002532
59 PROTEIN HOMODIMERIZATION ACTIVITY 113 722 0.0001646 0.002591
60 CORE PROMOTER PROXIMAL REGION DNA BINDING 65 371 0.0001896 0.002935
61 HISTONE DEACETYLASE BINDING 25 105 0.0002039 0.003105
62 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 174 1199 0.0002129 0.00319
63 SULFURIC ESTER HYDROLASE ACTIVITY 8 17 0.0002411 0.003555
64 PHOSPHORIC ESTER HYDROLASE ACTIVITY 64 368 0.000261 0.003789
65 ENZYME ACTIVATOR ACTIVITY 78 471 0.0002964 0.004236
66 BETA CATENIN BINDING 21 84 0.0003149 0.004432
67 PDZ DOMAIN BINDING 22 90 0.0003228 0.004476
68 WNT PROTEIN BINDING 11 31 0.000353 0.004823
69 SEMAPHORIN RECEPTOR BINDING 9 22 0.0003588 0.004831
70 CALMODULIN BINDING 36 179 0.0003752 0.004979
71 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 24 105 0.0005153 0.006742
72 CAMP BINDING 9 23 0.000531 0.006851
73 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 14 48 0.0005904 0.007412
74 PHOSPHOLIPID TRANSPORTER ACTIVITY 14 48 0.0005904 0.007412
75 CADHERIN BINDING 10 28 0.0006157 0.007627
76 HORMONE BINDING 17 65 0.0006536 0.007886
77 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 92 588 0.0006481 0.007886
78 RHO GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 19 77 0.0007096 0.008344
79 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 23 101 0.0007048 0.008344
80 KINASE INHIBITOR ACTIVITY 21 89 0.0007225 0.00839
81 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 21 90 0.0008441 0.009681
82 E BOX BINDING 11 34 0.0008674 0.009708
83 UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING 11 34 0.0008674 0.009708
84 DIVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 33 167 0.0008853 0.009791
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE REGION 238 1134 1.219e-22 7.119e-20
2 CELL JUNCTION 219 1151 1.023e-15 1.991e-13
3 CELL LEADING EDGE 93 350 9.699e-16 1.991e-13
4 MEMBRANE MICRODOMAIN 81 288 2.239e-15 3.269e-13
5 ANCHORING JUNCTION 113 489 3.824e-14 4.467e-12
6 PLASMA MEMBRANE REGION 180 929 8.275e-14 8.054e-12
7 GOLGI APPARATUS 253 1445 1.288e-13 1.075e-11
8 INTRINSIC COMPONENT OF PLASMA MEMBRANE 278 1649 6.869e-13 5.015e-11
9 NEURON PROJECTION 178 942 1.147e-12 7.44e-11
10 CELL PROJECTION 293 1786 4.12e-12 2.406e-10
11 NEURON PART 219 1265 2.073e-11 1.101e-09
12 CELL SUBSTRATE JUNCTION 89 398 1.274e-10 6.2e-09
13 AXON 92 418 1.521e-10 6.832e-09
14 CELL CELL JUNCTION 86 383 2.096e-10 8.744e-09
15 LAMELLIPODIUM 49 172 4.536e-10 1.766e-08
16 CELL PROJECTION PART 165 946 4.273e-09 1.56e-07
17 CELL SURFACE 138 757 5.023e-09 1.725e-07
18 INTRACELLULAR VESICLE 207 1259 6.939e-09 2.251e-07
19 PERINUCLEAR REGION OF CYTOPLASM 120 642 1.198e-08 3.682e-07
20 ACTIN CYTOSKELETON 90 444 1.768e-08 5.162e-07
21 APICAL PART OF CELL 77 361 2.008e-08 5.585e-07
22 VACUOLE 192 1180 5.6e-08 1.487e-06
23 SYNAPSE 133 754 7.304e-08 1.855e-06
24 CYTOSKELETON 294 1967 8.34e-08 2.029e-06
25 GOLGI APPARATUS PART 152 893 8.929e-08 2.086e-06
26 SIDE OF MEMBRANE 84 428 2.276e-07 5.112e-06
27 APICAL PLASMA MEMBRANE 63 292 2.479e-07 5.363e-06
28 CYTOPLASMIC REGION 62 287 2.938e-07 5.975e-06
29 AXON PART 51 219 2.967e-07 5.975e-06
30 CELL CORTEX 54 238 3.297e-07 6.417e-06
31 CORTICAL CYTOSKELETON 26 81 4.267e-07 8.038e-06
32 SOMATODENDRITIC COMPARTMENT 115 650 4.816e-07 8.523e-06
33 ENDOSOME 135 793 4.726e-07 8.523e-06
34 PROTEINACEOUS EXTRACELLULAR MATRIX 72 356 5.066e-07 8.702e-06
35 ENDOPLASMIC RETICULUM 245 1631 7.744e-07 1.292e-05
36 BASOLATERAL PLASMA MEMBRANE 48 211 1.342e-06 2.177e-05
37 EXTRACELLULAR MATRIX 81 426 1.405e-06 2.218e-05
38 CELL CORTEX PART 32 119 1.842e-06 2.758e-05
39 EXTERNAL SIDE OF PLASMA MEMBRANE 52 238 1.813e-06 2.758e-05
40 MAIN AXON 20 58 2.58e-06 3.767e-05
41 FILOPODIUM 27 94 2.954e-06 4.208e-05
42 T TUBULE 17 45 3.463e-06 4.816e-05
43 ACTIN FILAMENT 22 70 4.792e-06 6.508e-05
44 BASAL PART OF CELL 18 51 5.57e-06 7.392e-05
45 GOLGI MEMBRANE 116 703 1.342e-05 0.0001742
46 EXTRACELLULAR MATRIX COMPONENT 31 125 1.595e-05 0.0002025
47 ENDOCYTIC VESICLE 52 256 1.635e-05 0.0002032
48 SITE OF POLARIZED GROWTH 35 149 1.672e-05 0.0002035
49 PLASMA MEMBRANE RAFT 24 86 1.76e-05 0.0002098
50 VESICLE MEMBRANE 89 512 1.879e-05 0.0002195
51 CELL PROJECTION MEMBRANE 58 298 2.084e-05 0.0002387
52 RECEPTOR COMPLEX 62 327 2.54e-05 0.0002853
53 LEADING EDGE MEMBRANE 32 134 2.663e-05 0.0002934
54 BASAL PLASMA MEMBRANE 13 33 2.901e-05 0.0003137
55 VACUOLAR PART 113 694 3.126e-05 0.0003319
56 VACUOLAR MEMBRANE 98 587 3.87e-05 0.0004036
57 PROTEIN KINASE COMPLEX 24 90 3.994e-05 0.0004093
58 CORTICAL ACTIN CYTOSKELETON 18 58 4.149e-05 0.0004178
59 SARCOLEMMA 30 125 4.24e-05 0.0004197
60 RUFFLE 35 156 4.681e-05 0.0004557
61 CYTOPLASMIC VESICLE PART 99 601 6.043e-05 0.0005785
62 ENDOCYTIC VESICLE MEMBRANE 34 152 6.36e-05 0.000599
63 APICAL JUNCTION COMPLEX 30 128 6.797e-05 0.0006203
64 SYNAPSE PART 100 610 6.723e-05 0.0006203
65 BASEMENT MEMBRANE 24 93 7.083e-05 0.0006323
66 LATERAL PLASMA MEMBRANE 16 50 7.254e-05 0.0006323
67 DENDRITE 78 451 7.154e-05 0.0006323
68 POSTSYNAPSE 67 378 0.0001072 0.0009204
69 CELL CELL CONTACT ZONE 18 64 0.0001717 0.001453
70 MYELIN SHEATH 35 168 0.0002232 0.001862
71 LYTIC VACUOLE 86 526 0.0002312 0.001902
72 CELL BODY 81 494 0.000316 0.002563
73 PLASMA MEMBRANE PROTEIN COMPLEX 83 510 0.0003422 0.002738
74 ORGANELLE SUBCOMPARTMENT 55 311 0.000449 0.003543
75 EXCITATORY SYNAPSE 38 197 0.0006169 0.004791
76 EXTRINSIC COMPONENT OF MEMBRANE 46 252 0.0006317 0.004791
77 EARLY ENDOSOME 53 301 0.0006266 0.004791
78 LATE ENDOSOME 40 213 0.0007827 0.00586
79 COATED PIT 17 67 0.0009486 0.006762
80 AXONAL GROWTH CONE 8 20 0.0009161 0.006762
81 ENDOSOMAL PART 70 430 0.0009495 0.006762
82 ACTIN BASED CELL PROJECTION 35 181 0.0009451 0.006762
83 PARANODE REGION OF AXON 6 12 0.001019 0.007167
84 INTERCALATED DISC 14 51 0.001145 0.007962
85 CONTRACTILE FIBER 39 211 0.001232 0.008463
86 RECYCLING ENDOSOME 27 131 0.001307 0.008877
87 COATED VESICLE 42 234 0.001488 0.009985

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 68 295 5.243e-09 1.642e-07
2 PI3K_Akt_signaling_pathway_hsa04151 77 352 6.316e-09 1.642e-07
3 Focal_adhesion_hsa04510 51 199 1.09e-08 1.889e-07
4 Hippo_signaling_pathway_hsa04390 38 154 2.121e-06 2.758e-05
5 TNF_signaling_pathway_hsa04668 29 108 5.68e-06 5.907e-05
6 cGMP_PKG_signaling_pathway_hsa04022 38 163 8.954e-06 7.76e-05
7 Tight_junction_hsa04530 38 170 2.474e-05 0.0001838
8 cAMP_signaling_pathway_hsa04024 42 198 3.593e-05 0.0002336
9 Rap1_signaling_pathway_hsa04015 43 206 4.364e-05 0.0002521
10 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 32 139 5.739e-05 0.0002984
11 Ras_signaling_pathway_hsa04014 46 232 9.01e-05 0.0004259
12 TGF_beta_signaling_pathway_hsa04350 22 84 0.0001103 0.0004584
13 Regulation_of_actin_cytoskeleton_hsa04810 42 208 0.0001171 0.0004584
14 FoxO_signaling_pathway_hsa04068 30 132 0.0001234 0.0004584
15 HIF_1_signaling_pathway_hsa04066 24 100 0.0002381 0.0008254
16 Adherens_junction_hsa04520 19 72 0.0002849 0.000926
17 ECM_receptor_interaction_hsa04512 20 82 0.0006105 0.001867
18 AMPK_signaling_pathway_hsa04152 26 121 0.0008384 0.00221
19 Hippo_signaling_pathway_multiple_species_hsa04392 10 29 0.0008458 0.00221
20 Cellular_senescence_hsa04218 32 160 0.0008499 0.00221
21 mTOR_signaling_pathway_hsa04150 30 151 0.001353 0.003351
22 Cytokine_cytokine_receptor_interaction_hsa04060 47 270 0.00157 0.003657
23 Phospholipase_D_signaling_pathway_hsa04072 29 146 0.001617 0.003657
24 Endocytosis_hsa04144 43 244 0.001901 0.004118
25 Calcium_signaling_pathway_hsa04020 34 182 0.002032 0.004228
26 Gap_junction_hsa04540 19 88 0.003743 0.007485
27 ErbB_signaling_pathway_hsa04012 18 85 0.005816 0.01097
28 Sphingolipid_signaling_pathway_hsa04071 23 118 0.005906 0.01097
29 Wnt_signaling_pathway_hsa04310 27 146 0.006366 0.01141
30 p53_signaling_pathway_hsa04115 15 68 0.007658 0.01327
31 Cell_adhesion_molecules_.CAMs._hsa04514 26 145 0.0109 0.01828
32 Hedgehog_signaling_pathway_hsa04340 11 47 0.01346 0.02186
33 Apelin_signaling_pathway_hsa04371 24 137 0.01835 0.02892
34 Apoptosis_hsa04210 24 138 0.01992 0.03047
35 Jak_STAT_signaling_pathway_hsa04630 27 162 0.02378 0.03533
36 Mitophagy_animal_hsa04137 13 65 0.02732 0.03946
37 Ferroptosis_hsa04216 9 40 0.0308 0.04329
38 Oocyte_meiosis_hsa04114 21 124 0.03635 0.04974
39 Autophagy_animal_hsa04140 21 128 0.04887 0.06516
40 Necroptosis_hsa04217 23 164 0.1572 0.2043
41 NF_kappa_B_signaling_pathway_hsa04064 14 95 0.1778 0.2255
42 VEGF_signaling_pathway_hsa04370 9 59 0.2144 0.2654
43 Phosphatidylinositol_signaling_system_hsa04070 14 99 0.2202 0.2663
44 Lysosome_hsa04142 16 123 0.3072 0.363
45 Phagosome_hsa04145 19 152 0.3486 0.4028
46 Notch_signaling_pathway_hsa04330 6 48 0.458 0.5085
47 Peroxisome_hsa04146 10 83 0.4596 0.5085
48 Apoptosis_multiple_species_hsa04215 4 33 0.5174 0.5606
49 Autophagy_other_hsa04136 3 32 0.7143 0.7581
50 Cell_cycle_hsa04110 11 124 0.8375 0.871
51 ABC_transporters_hsa02010 3 45 0.8951 0.9056
52 Neuroactive_ligand_receptor_interaction_hsa04080 25 278 0.9056 0.9056

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 HCG11 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-502-3p;hsa-miR-93-5p 10 AKT3 Sponge network -0.781 0 -0.659 0.00047 0.574

Quest ID: 877de70fd0ea1aed6090169ae3e5513c