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show label of nodes with degree >=

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-744-3p ABCC4 2.75 0 -1.54 1.0E-5 MirTarget -0.14 0.00108 NA
2 hsa-miR-744-3p ADAMTSL3 2.75 0 -5.11 0 MirTarget -0.72 0 NA
3 hsa-miR-744-3p APBB2 2.75 0 -0.59 0.0014 MirTarget -0.14 0 NA
4 hsa-miR-744-3p ARNTL 2.75 0 -0.36 0.08956 miRNATAP -0.13 0 NA
5 hsa-miR-744-3p BEND4 2.75 0 -1.97 7.0E-5 MirTarget -0.3 0 NA
6 hsa-miR-744-3p BOC 2.75 0 -2.87 0 MirTarget -0.59 0 NA
7 hsa-miR-744-3p C5AR1 2.75 0 -1.17 0.00377 MirTarget -0.4 0 NA
8 hsa-miR-744-3p CASP10 2.75 0 0.09 0.71758 mirMAP -0.14 1.0E-5 NA
9 hsa-miR-744-3p CAV2 2.75 0 -0.86 0.01061 MirTarget -0.21 0 NA
10 hsa-miR-744-3p CCDC69 2.75 0 -2.71 0 MirTarget -0.43 0 NA
11 hsa-miR-744-3p CCR2 2.75 0 -0.81 0.0912 miRNAWalker2 validate -0.55 0 NA
12 hsa-miR-744-3p CD1D 2.75 0 -0.65 0.04266 MirTarget -0.31 0 NA
13 hsa-miR-744-3p CD302 2.75 0 -1.68 0 MirTarget -0.2 0 NA
14 hsa-miR-744-3p CHST15 2.75 0 -0.54 0.20793 miRNATAP -0.28 0 NA
15 hsa-miR-744-3p CHST3 2.75 0 -0.88 0.0075 mirMAP -0.17 8.0E-5 NA
16 hsa-miR-744-3p CHURC1 2.75 0 -0.79 0 mirMAP -0.1 0 NA
17 hsa-miR-744-3p CIITA 2.75 0 -0.02 0.95968 mirMAP -0.36 0 NA
18 hsa-miR-744-3p CLEC5A 2.75 0 2.07 1.0E-5 MirTarget -0.19 0.0011 NA
19 hsa-miR-744-3p CNTN4 2.75 0 -3.06 0 miRNATAP -0.42 0 NA
20 hsa-miR-744-3p CYP27C1 2.75 0 -0.53 0.39796 MirTarget -0.28 0.00053 NA
21 hsa-miR-744-3p DIP2C 2.75 0 -1.11 0 MirTarget -0.11 0.00023 NA
22 hsa-miR-744-3p DST 2.75 0 -1.12 9.0E-5 mirMAP -0.15 7.0E-5 NA
23 hsa-miR-744-3p DUSP22 2.75 0 -0.79 0 mirMAP -0.14 0 NA
24 hsa-miR-744-3p FAT3 2.75 0 -2.79 0 MirTarget -0.44 0 NA
25 hsa-miR-744-3p FGF9 2.75 0 -4.26 0 miRNATAP -0.48 0 NA
26 hsa-miR-744-3p GFOD1 2.75 0 -0.94 0.00661 mirMAP -0.23 0 NA
27 hsa-miR-744-3p GPM6B 2.75 0 -2.39 0 MirTarget; miRNATAP -0.26 0 NA
28 hsa-miR-744-3p HLF 2.75 0 -5.48 0 MirTarget -0.78 0 NA
29 hsa-miR-744-3p HUNK 2.75 0 -2.27 1.0E-5 mirMAP -0.21 0.00192 NA
30 hsa-miR-744-3p IGFBP5 2.75 0 -2.81 0 MirTarget -0.54 0 NA
31 hsa-miR-744-3p IL16 2.75 0 -1.47 0 mirMAP -0.43 0 NA
32 hsa-miR-744-3p ITGBL1 2.75 0 -1.2 0.03208 MirTarget -0.53 0 NA
33 hsa-miR-744-3p KCNMA1 2.75 0 -3.78 0 miRNATAP -0.67 0 NA
34 hsa-miR-744-3p KIAA1614 2.75 0 -2.01 0 mirMAP -0.29 0 NA
35 hsa-miR-744-3p KIAA1644 2.75 0 -4.4 0 mirMAP -0.79 0 NA
36 hsa-miR-744-3p KLF13 2.75 0 -1.16 1.0E-5 mirMAP -0.15 1.0E-5 NA
37 hsa-miR-744-3p LPP 2.75 0 -2.04 0 mirMAP -0.27 0 NA
38 hsa-miR-744-3p MAN1A1 2.75 0 -1.2 0.00088 MirTarget -0.16 0.00053 NA
39 hsa-miR-744-3p MBNL3 2.75 0 -1.4 8.0E-5 miRNATAP -0.1 0.02284 NA
40 hsa-miR-744-3p MEF2C 2.75 0 -2.13 0 MirTarget; miRNATAP -0.37 0 NA
41 hsa-miR-744-3p NFE2 2.75 0 -0.46 0.36909 MirTarget -0.2 0.00232 NA
42 hsa-miR-744-3p NPTN 2.75 0 -0.74 0 MirTarget; miRNATAP -0.13 0 NA
43 hsa-miR-744-3p NPTXR 2.75 0 -1.27 0.01306 mirMAP -0.22 0.00091 NA
44 hsa-miR-744-3p NTRK3 2.75 0 -5.17 0 mirMAP -0.68 0 NA
45 hsa-miR-744-3p OR51E2 2.75 0 -0.76 0.07044 MirTarget -0.27 0 NA
46 hsa-miR-744-3p PDLIM2 2.75 0 -1.12 2.0E-5 mirMAP -0.25 0 NA
47 hsa-miR-744-3p PIP4K2A 2.75 0 -0.91 0 mirMAP -0.19 0 NA
48 hsa-miR-744-3p PLXDC1 2.75 0 0 0.99489 mirMAP -0.16 1.0E-5 NA
49 hsa-miR-744-3p PRELP 2.75 0 -4.33 0 mirMAP -0.85 0 NA
50 hsa-miR-744-3p PTPN5 2.75 0 -1.67 0.00068 MirTarget -0.46 0 NA
51 hsa-miR-744-3p PTPRT 2.75 0 -1.15 0.06031 mirMAP -0.28 0.00031 NA
52 hsa-miR-744-3p RHOB 2.75 0 -2.2 0 MirTarget -0.16 0 NA
53 hsa-miR-744-3p RORA 2.75 0 -1.82 0 miRNATAP -0.21 0 NA
54 hsa-miR-744-3p SCN2B 2.75 0 -4.29 0 MirTarget -0.65 0 NA
55 hsa-miR-744-3p SELE 2.75 0 -3.25 0 MirTarget -0.45 0 NA
56 hsa-miR-744-3p SHROOM4 2.75 0 -0.92 0.0019 MirTarget -0.1 0.00742 NA
57 hsa-miR-744-3p SIGLEC10 2.75 0 0.05 0.91324 MirTarget -0.46 0 NA
58 hsa-miR-744-3p SSPN 2.75 0 -1.94 0 MirTarget -0.34 0 NA
59 hsa-miR-744-3p TIFAB 2.75 0 -0.38 0.46102 mirMAP -0.43 0 NA
60 hsa-miR-744-3p TMEM140 2.75 0 0.02 0.91392 MirTarget -0.17 0 NA
61 hsa-miR-744-3p TMOD1 2.75 0 -2.51 0 MirTarget -0.32 0 NA
62 hsa-miR-744-3p TRAM2 2.75 0 -0.48 0.0152 mirMAP -0.11 1.0E-5 NA
63 hsa-miR-744-3p TXLNB 2.75 0 -2.44 0 MirTarget -0.5 0 NA
64 hsa-miR-744-3p VIPR2 2.75 0 -5.16 0 mirMAP -0.76 0 NA
65 hsa-miR-744-3p WDFY4 2.75 0 -1.53 0.00209 mirMAP -0.6 0 NA
66 hsa-miR-744-3p ZNF676 2.75 0 -2.15 0.00067 MirTarget -0.25 0.00247 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 TNF_signaling_pathway_hsa04668 2 108 0.04956 1
2 MAPK_signaling_pathway_hsa04010 3 295 0.07381 1
3 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.1011 1
4 cAMP_signaling_pathway_hsa04024 2 198 0.139 1
5 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.1503 1
6 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.2336 1

Quest ID: 87e2e5f09e97b87bfe936fadf7676163