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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-17-5p ABCA1 3.27 0 -0.71 0.00276 MirTarget; TargetScan; miRNATAP -0.18 0 NA
2 hsa-miR-17-5p ABCD2 3.27 0 -3.08 0 MirTarget -0.6 0 NA
3 hsa-miR-17-5p ABHD2 3.27 0 -0.37 0.12248 TargetScan; miRNATAP -0.11 0.00236 NA
4 hsa-miR-17-5p ACOT2 3.27 0 -0.56 0.00263 miRNAWalker2 validate -0.13 0 NA
5 hsa-miR-17-5p ACVRL1 3.27 0 -1.25 0 TargetScan -0.26 0 NA
6 hsa-miR-17-5p ADAM19 3.27 0 -1.06 0.01895 mirMAP -0.35 0 NA
7 hsa-miR-17-5p ADAM9 3.27 0 -0.2 0.40665 TargetScan; miRNATAP -0.16 1.0E-5 NA
8 hsa-miR-17-5p ADAMTS5 3.27 0 -2.16 0 TargetScan -0.37 0 NA
9 hsa-miR-17-5p ADAMTSL2 3.27 0 -0.34 0.24934 TargetScan -0.11 0.01243 NA
10 hsa-miR-17-5p ADARB1 3.27 0 -1.93 0 miRNAWalker2 validate; MirTarget -0.35 0 NA
11 hsa-miR-17-5p ADCY9 3.27 0 -1.5 0 mirMAP -0.31 0 NA
12 hsa-miR-17-5p ADRA1B 3.27 0 -0.45 0.38166 TargetScan -0.22 0.0039 NA
13 hsa-miR-17-5p AFF4 3.27 0 -0.82 0 TargetScan; miRNATAP -0.12 0 NA
14 hsa-miR-17-5p AGFG2 3.27 0 -0.51 0.00539 TargetScan; miRNATAP -0.14 0 NA
15 hsa-miR-17-5p AHNAK 3.27 0 -1.66 0 TargetScan; miRNATAP -0.33 0 NA
16 hsa-miR-17-5p AJAP1 3.27 0 -1.65 0.0004 TargetScan -0.18 0.01052 NA
17 hsa-miR-17-5p AKAP11 3.27 0 -0.8 0 MirTarget; TargetScan -0.15 0 NA
18 hsa-miR-17-5p AKAP13 3.27 0 -1.15 0 MirTarget; TargetScan; mirMAP; miRNATAP -0.26 0 NA
19 hsa-miR-17-5p AKT3 3.27 0 -1.94 0 TargetScan; miRNATAP -0.39 0 NA
20 hsa-miR-17-5p AKTIP 3.27 0 -0.35 0.01135 MirTarget; TargetScan; miRNATAP -0.13 0 NA
21 hsa-miR-17-5p ALPK3 3.27 0 -1.02 0.00049 mirMAP -0.3 0 NA
22 hsa-miR-17-5p ANK2 3.27 0 -4.32 0 MirTarget; miRNATAP -0.75 0 NA
23 hsa-miR-17-5p ANKH 3.27 0 -0.38 0.21654 MirTarget; TargetScan -0.22 0 NA
24 hsa-miR-17-5p ANKRD13A 3.27 0 -0.29 0.0581 mirMAP -0.11 0 NA
25 hsa-miR-17-5p ANKRD29 3.27 0 -3.47 0 MirTarget; TargetScan -0.71 0 NA
26 hsa-miR-17-5p ANKRD50 3.27 0 -0.88 0.00174 MirTarget; TargetScan; miRNATAP -0.18 2.0E-5 NA
27 hsa-miR-17-5p ANO6 3.27 0 -0.74 3.0E-5 MirTarget; TargetScan; miRNATAP -0.14 0 NA
28 hsa-miR-17-5p ANXA11 3.27 0 -0.43 0.01849 mirMAP -0.11 2.0E-5 NA
29 hsa-miR-17-5p APBB2 3.27 0 -0.59 0.0014 MirTarget; TargetScan; miRNATAP -0.19 0 NA
30 hsa-miR-17-5p APCDD1 3.27 0 -1.6 0 MirTarget; TargetScan -0.2 0.00015 NA
31 hsa-miR-17-5p APP 3.27 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.16 0 NA
32 hsa-miR-17-5p AR 3.27 0 -3.3 0 mirMAP -0.52 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
33 hsa-miR-17-5p ARHGAP1 3.27 0 -0.88 0 MirTarget; TargetScan; miRNATAP -0.23 0 NA
34 hsa-miR-17-5p ARHGAP10 3.27 0 -1.37 0 miRNAWalker2 validate -0.19 0 NA
35 hsa-miR-17-5p ARHGAP24 3.27 0 -2.02 0 MirTarget -0.46 0 NA
36 hsa-miR-17-5p ARHGAP26 3.27 0 -0.72 0.00357 MirTarget; TargetScan; mirMAP; miRNATAP -0.11 0.00432 NA
37 hsa-miR-17-5p ARHGAP31 3.27 0 -1.16 2.0E-5 TargetScan -0.32 0 NA
38 hsa-miR-17-5p ARHGAP5 3.27 0 -0.63 0.00047 miRNAWalker2 validate -0.13 0 NA
39 hsa-miR-17-5p ARHGEF10 3.27 0 -1.15 1.0E-5 TargetScan -0.23 0 NA
40 hsa-miR-17-5p ARHGEF3 3.27 0 -0.76 0 MirTarget; TargetScan; miRNATAP -0.17 0 NA
41 hsa-miR-17-5p ARL10 3.27 0 -1.12 0.00198 mirMAP -0.19 0.00033 NA
42 hsa-miR-17-5p ARL4C 3.27 0 -0.28 0.33535 MirTarget; TargetScan; miRNATAP -0.19 1.0E-5 NA
43 hsa-miR-17-5p ARSJ 3.27 0 -1.58 0.00066 TargetScan -0.42 0 NA
44 hsa-miR-17-5p ASH1L 3.27 0 -0.67 0.00016 miRNAWalker2 validate; miRNATAP -0.12 1.0E-5 NA
45 hsa-miR-17-5p ASPA 3.27 0 -4.76 0 mirMAP -0.71 0 NA
46 hsa-miR-17-5p ASXL2 3.27 0 -0.51 0.09339 TargetScan -0.11 0.01176 NA
47 hsa-miR-17-5p ASXL3 3.27 0 -3.34 0 TargetScan -0.48 0 NA
48 hsa-miR-17-5p ATE1 3.27 0 -1.09 3.0E-5 MirTarget; TargetScan -0.18 0 NA
49 hsa-miR-17-5p ATF3 3.27 0 -3.23 0 miRNAWalker2 validate -0.36 0 NA
50 hsa-miR-17-5p ATOH8 3.27 0 -2.58 1.0E-5 TargetScan -0.28 0.00101 NA
51 hsa-miR-17-5p ATP1A2 3.27 0 -6.96 0 MirTarget; TargetScan -1.3 0 NA
52 hsa-miR-17-5p ATRX 3.27 0 -0.65 1.0E-5 miRNAWalker2 validate; mirMAP -0.11 0 NA
53 hsa-miR-17-5p ATXN1 3.27 0 -1.51 0 TargetScan; miRNATAP -0.37 0 NA
54 hsa-miR-17-5p ATXN7L1 3.27 0 -0.62 4.0E-5 TargetScan -0.11 0 NA
55 hsa-miR-17-5p B3GALT2 3.27 0 -3.85 0 MirTarget; TargetScan -0.51 0 NA
56 hsa-miR-17-5p BACE1 3.27 0 -0.72 0.00096 miRNAWalker2 validate -0.19 0 NA
57 hsa-miR-17-5p BAG2 3.27 0 -2.37 0 TargetScan -0.4 0 NA
58 hsa-miR-17-5p BBX 3.27 0 -0.51 0.00131 MirTarget; TargetScan; miRNATAP -0.11 0 NA
59 hsa-miR-17-5p BCAS1 3.27 0 -0.72 0.38851 mirMAP -0.32 0.00931 NA
60 hsa-miR-17-5p BCL2 3.27 0 -2.02 0 miRNAWalker2 validate; miRTarBase -0.29 0 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
61 hsa-miR-17-5p BCL2L2 3.27 0 -1.27 0 TargetScan; miRNATAP -0.14 0 NA
62 hsa-miR-17-5p BCL6 3.27 0 -0.56 0.00743 TargetScan -0.15 0 NA
63 hsa-miR-17-5p BEND4 3.27 0 -1.97 7.0E-5 mirMAP -0.25 0.00095 NA
64 hsa-miR-17-5p BICC1 3.27 0 -1.47 0.01393 TargetScan -0.49 0 NA
65 hsa-miR-17-5p BLVRA 3.27 0 -0.51 0.04098 miRNAWalker2 validate -0.13 0.00045 NA
66 hsa-miR-17-5p BMP2 3.27 0 -1.46 0.00276 TargetScan -0.18 0.01393 NA
67 hsa-miR-17-5p BMP7 3.27 0 -1.78 0.02876 mirMAP -0.3 0.01237 NA
68 hsa-miR-17-5p BMPR2 3.27 0 -0.59 4.0E-5 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.21 0 NA
69 hsa-miR-17-5p BNC2 3.27 0 -2.95 0 TargetScan; miRNATAP -0.79 0 NA
70 hsa-miR-17-5p BTG1 3.27 0 -0.8 2.0E-5 TargetScan -0.11 0.00011 NA
71 hsa-miR-17-5p BTG2 3.27 0 -2.39 0 TargetScan -0.29 0 NA
72 hsa-miR-17-5p BVES 3.27 0 -2.76 0 TargetScan -0.45 0 NA
73 hsa-miR-17-5p C14orf28 3.27 0 -0.89 0 TargetScan; miRNATAP -0.16 0 NA
74 hsa-miR-17-5p C3orf70 3.27 0 -2.6 0 TargetScan -0.38 0 NA
75 hsa-miR-17-5p CA5B 3.27 0 -1.09 0 mirMAP -0.17 0 NA
76 hsa-miR-17-5p CADM2 3.27 0 -3.84 0 MirTarget; TargetScan; miRNATAP -0.28 0.00121 NA
77 hsa-miR-17-5p CALD1 3.27 0 -2.47 0 TargetScan; miRNATAP -0.65 0 NA
78 hsa-miR-17-5p CASC4 3.27 0 -0.27 0.06567 MirTarget -0.13 0 NA
79 hsa-miR-17-5p CBX7 3.27 0 -2.55 0 mirMAP -0.4 0 NA
80 hsa-miR-17-5p CCBE1 3.27 0 -1.07 0.09592 mirMAP -0.19 0.0451 NA
81 hsa-miR-17-5p CCDC50 3.27 0 -0.78 0 TargetScan -0.1 0 NA
82 hsa-miR-17-5p CCND2 3.27 0 -2.43 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.58 0 NA
83 hsa-miR-17-5p CD226 3.27 0 -1.61 0.00025 TargetScan -0.36 0 NA
84 hsa-miR-17-5p CD69 3.27 0 -2.49 0 TargetScan; miRNATAP -0.48 0 NA
85 hsa-miR-17-5p CDC37L1 3.27 0 -1.08 0 MirTarget; TargetScan; miRNATAP -0.13 0 NA
86 hsa-miR-17-5p CDH19 3.27 0 -5.09 0 TargetScan -0.81 0 NA
87 hsa-miR-17-5p CDK6 3.27 0 -0.77 0.06479 TargetScan; mirMAP -0.17 0.00702 NA
88 hsa-miR-17-5p CDKN1A 3.27 0 -1.29 0 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan; miRNATAP -0.17 3.0E-5 26482648; 24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA
89 hsa-miR-17-5p CELF2 3.27 0 -3.05 0 TargetScan -0.65 0 NA
90 hsa-miR-17-5p CERCAM 3.27 0 0.21 0.50968 MirTarget; TargetScan -0.13 0.00693 NA
91 hsa-miR-17-5p CERK 3.27 0 -1.14 9.0E-5 mirMAP -0.17 8.0E-5 NA
92 hsa-miR-17-5p CFL2 3.27 0 -2.62 0 MirTarget; TargetScan; miRNATAP -0.43 0 NA
93 hsa-miR-17-5p CHD5 3.27 0 -3.46 0 MirTarget; TargetScan; miRNATAP -0.29 2.0E-5 NA
94 hsa-miR-17-5p CHD9 3.27 0 -0.8 1.0E-5 MirTarget; TargetScan; miRNATAP -0.17 0 NA
95 hsa-miR-17-5p CHIC1 3.27 0 -1.03 0 TargetScan -0.19 0 NA
96 hsa-miR-17-5p CHRM2 3.27 0 -5.86 0 TargetScan -1.19 0 NA
97 hsa-miR-17-5p CHST7 3.27 0 -0.45 0.07221 TargetScan -0.12 0.00097 NA
98 hsa-miR-17-5p CIITA 3.27 0 -0.02 0.95968 mirMAP -0.19 0.00581 NA
99 hsa-miR-17-5p CLDN16 3.27 0 0.26 0.60929 mirMAP -0.18 0.01736 NA
100 hsa-miR-17-5p CLIC6 3.27 0 -1.31 0.0574 mirMAP -0.23 0.02792 NA
101 hsa-miR-17-5p CLIP4 3.27 0 -1.61 0 MirTarget; TargetScan -0.36 0 NA
102 hsa-miR-17-5p CLOCK 3.27 0 -0.51 0.03689 MirTarget; TargetScan -0.11 0.00143 NA
103 hsa-miR-17-5p CLUAP1 3.27 0 -0.82 3.0E-5 mirMAP -0.12 6.0E-5 NA
104 hsa-miR-17-5p CMKLR1 3.27 0 -0.94 0.03112 TargetScan -0.36 0 NA
105 hsa-miR-17-5p CNN1 3.27 0 -5.79 0 TargetScan -1.33 0 NA
106 hsa-miR-17-5p CNR2 3.27 0 -2.05 6.0E-5 mirMAP -0.48 0 NA
107 hsa-miR-17-5p COL19A1 3.27 0 -5.13 0 TargetScan -0.87 0 NA
108 hsa-miR-17-5p COL1A1 3.27 0 -0.11 0.82007 mirMAP -0.48 0 NA
109 hsa-miR-17-5p COL4A1 3.27 0 0.15 0.58169 TargetScan -0.19 0 NA
110 hsa-miR-17-5p COL4A3 3.27 0 -3.14 0 MirTarget; TargetScan; miRNATAP -0.3 0.00178 NA
111 hsa-miR-17-5p COL8A2 3.27 0 -1.27 0.00295 mirMAP -0.58 0 NA
112 hsa-miR-17-5p CORO2B 3.27 0 -2.03 0 MirTarget; TargetScan; miRNATAP -0.36 0 NA
113 hsa-miR-17-5p CPE 3.27 0 -1.66 0 miRNAWalker2 validate -0.31 0 NA
114 hsa-miR-17-5p CPEB3 3.27 0 -1.3 0 TargetScan; miRNATAP -0.24 0 NA
115 hsa-miR-17-5p CPEB4 3.27 0 -1.56 0 mirMAP -0.3 0 NA
116 hsa-miR-17-5p CPS1 3.27 0 -1.12 0.04051 miRNAWalker2 validate -0.17 0.03344 NA
117 hsa-miR-17-5p CPT1A 3.27 0 -0.83 0.00093 mirMAP -0.2 0 NA
118 hsa-miR-17-5p CREB3L2 3.27 0 -0.29 0.1662 mirMAP -0.19 0 NA
119 hsa-miR-17-5p CREB5 3.27 0 -2.28 0 MirTarget; TargetScan; miRNATAP -0.34 0 NA
120 hsa-miR-17-5p CRIM1 3.27 0 -0.45 0.0534 MirTarget; TargetScan; miRNATAP -0.18 0 NA
121 hsa-miR-17-5p CROT 3.27 0 -0.3 0.34241 MirTarget -0.13 0.00792 NA
122 hsa-miR-17-5p CRTC3 3.27 0 -0.76 0 TargetScan -0.16 0 NA
123 hsa-miR-17-5p CRY2 3.27 0 -1.68 0 MirTarget; TargetScan; miRNATAP -0.23 0 NA
124 hsa-miR-17-5p CRYBG3 3.27 0 -1.11 5.0E-5 MirTarget; TargetScan; miRNATAP -0.29 0 NA
125 hsa-miR-17-5p CSF1 3.27 0 -1.3 0.00033 TargetScan; miRNATAP -0.39 0 NA
126 hsa-miR-17-5p CSGALNACT1 3.27 0 -2.42 0 MirTarget; TargetScan -0.38 0 NA
127 hsa-miR-17-5p CTSK 3.27 0 -1.41 0.00081 MirTarget -0.55 0 NA
128 hsa-miR-17-5p CXCL14 3.27 0 -1.98 0.0026 TargetScan -0.52 0 NA
129 hsa-miR-17-5p CXorf36 3.27 0 -1.52 0 mirMAP -0.3 0 NA
130 hsa-miR-17-5p CYBRD1 3.27 0 -2.55 0 MirTarget; TargetScan -0.54 0 NA
131 hsa-miR-17-5p CYP2U1 3.27 0 -1.21 0 MirTarget; TargetScan -0.25 0 NA
132 hsa-miR-17-5p DAB2 3.27 0 -0.69 0.03265 MirTarget; TargetScan; miRNATAP -0.32 0 NA
133 hsa-miR-17-5p DCUN1D3 3.27 0 -1.23 0 MirTarget; TargetScan -0.13 0 NA
134 hsa-miR-17-5p DENND5B 3.27 0 -1.35 0.0001 MirTarget; TargetScan; miRNATAP -0.21 4.0E-5 NA
135 hsa-miR-17-5p DIP2C 3.27 0 -1.11 0 TargetScan -0.16 0 NA
136 hsa-miR-17-5p DIXDC1 3.27 0 -3.01 0 mirMAP -0.57 0 NA
137 hsa-miR-17-5p DLG2 3.27 0 -3.8 0 mirMAP -0.69 0 NA
138 hsa-miR-17-5p DNAJB9 3.27 0 -0.44 0.00239 TargetScan; miRNATAP -0.16 0 NA
139 hsa-miR-17-5p DNAJC15 3.27 0 -0.47 0.23598 TargetScan -0.18 0.00284 NA
140 hsa-miR-17-5p DNAJC27 3.27 0 -0.9 0 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan; miRNATAP -0.13 0 NA
141 hsa-miR-17-5p DNMBP 3.27 0 -0.9 0.00012 miRNAWalker2 validate -0.13 0.00018 NA
142 hsa-miR-17-5p DOK6 3.27 0 -3.8 0 TargetScan -0.73 0 NA
143 hsa-miR-17-5p DPF3 3.27 0 -1.67 1.0E-5 TargetScan -0.25 1.0E-5 NA
144 hsa-miR-17-5p DPP8 3.27 0 -0.52 0.02104 mirMAP -0.14 3.0E-5 NA
145 hsa-miR-17-5p DPYD 3.27 0 -1.71 0.00028 MirTarget -0.46 0 NA
146 hsa-miR-17-5p DPYSL2 3.27 0 -1.76 0 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.35 0 NA
147 hsa-miR-17-5p DRD1 3.27 0 -1.6 0.0138 TargetScan -0.3 0.00225 NA
148 hsa-miR-17-5p DST 3.27 0 -1.12 9.0E-5 mirMAP -0.24 0 NA
149 hsa-miR-17-5p DUSP8 3.27 0 -2.17 0 MirTarget; TargetScan; miRNATAP -0.27 0 NA
150 hsa-miR-17-5p EDA2R 3.27 0 -1.5 0.00021 MirTarget; TargetScan -0.35 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 115 1518 4.454e-18 2.072e-14
2 POSITIVE REGULATION OF GENE EXPRESSION 122 1733 1.087e-16 2.529e-13
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 123 1848 5.466e-15 8.478e-12
4 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 120 1805 1.383e-14 1.319e-11
5 CARDIOVASCULAR SYSTEM DEVELOPMENT 70 788 1.7e-14 1.319e-11
6 CIRCULATORY SYSTEM DEVELOPMENT 70 788 1.7e-14 1.319e-11
7 RESPONSE TO ENDOGENOUS STIMULUS 103 1450 2.366e-14 1.573e-11
8 REGULATION OF PHOSPHORUS METABOLIC PROCESS 110 1618 5.075e-14 2.952e-11
9 REGULATION OF CELL DIFFERENTIATION 104 1492 5.843e-14 3.021e-11
10 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 117 1784 8.238e-14 3.833e-11
11 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 80 1008 9.326e-14 3.945e-11
12 SKELETAL SYSTEM DEVELOPMENT 48 455 6.421e-13 2.49e-10
13 INTRACELLULAR SIGNAL TRANSDUCTION 103 1572 3.614e-12 1.294e-09
14 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 76 1004 4.376e-12 1.454e-09
15 MUSCLE STRUCTURE DEVELOPMENT 45 432 5.368e-12 1.665e-09
16 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 106 1656 6.892e-12 2.004e-09
17 REGULATION OF PROTEIN MODIFICATION PROCESS 108 1710 9.551e-12 2.614e-09
18 CELL DEVELOPMENT 95 1426 1.145e-11 2.959e-09
19 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 61 740 2.204e-11 5.398e-09
20 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 64 799 2.346e-11 5.458e-09
21 REGULATION OF CELLULAR COMPONENT MOVEMENT 62 771 4.19e-11 9.284e-09
22 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 75 1036 5.123e-11 1.036e-08
23 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 75 1036 5.123e-11 1.036e-08
24 HEART DEVELOPMENT 45 466 6.914e-11 1.34e-08
25 ORGAN MORPHOGENESIS 65 841 7.454e-11 1.387e-08
26 EPITHELIUM DEVELOPMENT 70 945 8.772e-11 1.57e-08
27 MUSCLE TISSUE DEVELOPMENT 33 275 9.849e-11 1.697e-08
28 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 103 1672 1.331e-10 2.212e-08
29 POSITIVE REGULATION OF LOCOMOTION 41 420 3.581e-10 5.555e-08
30 RESPONSE TO HORMONE 66 893 3.485e-10 5.555e-08
31 NEGATIVE REGULATION OF CELL PROLIFERATION 53 643 4.903e-10 7.359e-08
32 TUBE DEVELOPMENT 48 552 5.757e-10 8.37e-08
33 OSSIFICATION 30 251 7.77e-10 1.096e-07
34 NEGATIVE REGULATION OF CELL COMMUNICATION 79 1192 9.915e-10 1.357e-07
35 CELLULAR RESPONSE TO LIPID 42 457 1.374e-09 1.826e-07
36 NEGATIVE REGULATION OF GENE EXPRESSION 92 1493 1.504e-09 1.944e-07
37 CELLULAR RESPONSE TO HORMONE STIMULUS 47 552 1.736e-09 2.183e-07
38 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 54 689 2.034e-09 2.491e-07
39 POSITIVE REGULATION OF MOLECULAR FUNCTION 104 1791 2.848e-09 3.398e-07
40 NEUROGENESIS 87 1402 3.212e-09 3.534e-07
41 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 91 1492 3.113e-09 3.534e-07
42 REGULATION OF SYSTEM PROCESS 44 507 3.266e-09 3.534e-07
43 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 75 1135 3.139e-09 3.534e-07
44 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 91 1517 7.008e-09 7.411e-07
45 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 41 465 7.227e-09 7.473e-07
46 VASCULATURE DEVELOPMENT 41 469 9.236e-09 9.343e-07
47 CARTILAGE DEVELOPMENT 21 147 1.191e-08 1.179e-06
48 RESPONSE TO OXYGEN CONTAINING COMPOUND 84 1381 1.551e-08 1.503e-06
49 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 83 1360 1.645e-08 1.562e-06
50 REGULATION OF OSSIFICATION 23 178 1.704e-08 1.586e-06
51 POSITIVE REGULATION OF CELL COMMUNICATION 90 1532 2.308e-08 2.066e-06
52 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 57 801 2.297e-08 2.066e-06
53 BONE DEVELOPMENT 21 156 3.458e-08 3.035e-06
54 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 42 513 3.988e-08 3.436e-06
55 EPITHELIAL CELL DIFFERENTIATION 41 495 4.213e-08 3.564e-06
56 UROGENITAL SYSTEM DEVELOPMENT 30 299 4.632e-08 3.781e-06
57 NEGATIVE REGULATION OF PHOSPHORYLATION 37 422 4.584e-08 3.781e-06
58 POSITIVE REGULATION OF CATALYTIC ACTIVITY 88 1518 6.185e-08 4.962e-06
59 POSITIVE REGULATION OF RESPONSE TO STIMULUS 105 1929 6.975e-08 5.501e-06
60 CONNECTIVE TISSUE DEVELOPMENT 23 194 8.628e-08 6.581e-06
61 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 64 983 8.537e-08 6.581e-06
62 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 59 876 8.923e-08 6.697e-06
63 REGULATION OF CELL DEVELOPMENT 57 836 9.918e-08 7.325e-06
64 RESPONSE TO NITROGEN COMPOUND 58 859 1.061e-07 7.713e-06
65 BLOOD VESSEL MORPHOGENESIS 33 364 1.131e-07 8.096e-06
66 TISSUE MORPHOGENESIS 42 533 1.155e-07 8.145e-06
67 BEHAVIOR 41 516 1.311e-07 9.103e-06
68 RESPONSE TO STEROID HORMONE 40 497 1.332e-07 9.117e-06
69 SKELETAL SYSTEM MORPHOGENESIS 23 201 1.656e-07 1.117e-05
70 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 24 218 1.857e-07 1.234e-05
71 CELLULAR RESPONSE TO NITROGEN COMPOUND 40 505 2.03e-07 1.331e-05
72 NEGATIVE REGULATION OF CELL DIFFERENTIATION 45 609 2.572e-07 1.662e-05
73 SENSORY ORGAN DEVELOPMENT 39 493 2.984e-07 1.902e-05
74 DEVELOPMENTAL MATURATION 22 193 3.279e-07 2.062e-05
75 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 27 278 4.18e-07 2.561e-05
76 RESPONSE TO ORGANIC CYCLIC COMPOUND 59 917 4.183e-07 2.561e-05
77 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 541 4.6e-07 2.744e-05
78 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 41 541 4.6e-07 2.744e-05
79 REGULATION OF CELL PROLIFERATION 84 1496 4.929e-07 2.903e-05
80 PROTEIN PHOSPHORYLATION 60 944 4.994e-07 2.905e-05
81 POSITIVE REGULATION OF CELL DEATH 44 605 5.415e-07 3.11e-05
82 STEROID HORMONE MEDIATED SIGNALING PATHWAY 17 125 5.976e-07 3.391e-05
83 POSITIVE REGULATION OF CELL DIFFERENTIATION 54 823 7.283e-07 4.083e-05
84 RESPONSE TO ABIOTIC STIMULUS 63 1024 7.799e-07 4.32e-05
85 TUBE MORPHOGENESIS 29 323 8.106e-07 4.437e-05
86 MUSCLE CELL DIFFERENTIATION 24 237 8.644e-07 4.677e-05
87 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 68 1142 8.944e-07 4.729e-05
88 CENTRAL NERVOUS SYSTEM DEVELOPMENT 56 872 8.864e-07 4.729e-05
89 NEURON DIFFERENTIATION 56 874 9.523e-07 4.979e-05
90 REGULATION OF MAPK CASCADE 46 660 9.788e-07 5.06e-05
91 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 21 190 1.009e-06 5.159e-05
92 MUSCLE ORGAN DEVELOPMENT 26 277 1.307e-06 6.609e-05
93 REGULATION OF KINASE ACTIVITY 51 776 1.428e-06 7.146e-05
94 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 62 1021 1.479e-06 7.322e-05
95 RESPONSE TO LIPID 56 888 1.559e-06 7.636e-05
96 RHYTHMIC PROCESS 27 298 1.626e-06 7.879e-05
97 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 59 957 1.67e-06 8.013e-05
98 CELLULAR RESPONSE TO EXTERNAL STIMULUS 25 264 1.774e-06 8.407e-05
99 ACTIN FILAMENT BASED PROCESS 35 450 1.789e-06 8.407e-05
100 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 48 724 2.311e-06 0.0001075
101 CELLULAR COMPONENT MORPHOGENESIS 56 900 2.351e-06 0.0001083
102 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 77 1395 2.951e-06 0.0001342
103 CARDIAC MUSCLE TISSUE DEVELOPMENT 17 140 2.97e-06 0.0001342
104 CHONDROCYTE DIFFERENTIATION 11 60 3.068e-06 0.0001373
105 REGULATION OF OSTEOBLAST DIFFERENTIATION 15 112 3.318e-06 0.000147
106 REGULATION OF CELL ADHESION 43 629 3.643e-06 0.0001599
107 RESPONSE TO EXTERNAL STIMULUS 94 1821 3.772e-06 0.000164
108 REGULATION OF BLOOD CIRCULATION 26 295 4.196e-06 0.0001808
109 VENOUS BLOOD VESSEL DEVELOPMENT 6 15 4.406e-06 0.0001881
110 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 71 1275 5.499e-06 0.0002305
111 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 162 5.49e-06 0.0002305
112 REGULATION OF CIRCADIAN RHYTHM 14 103 5.883e-06 0.0002444
113 LOCOMOTION 64 1114 6.174e-06 0.000252
114 REGULATION OF CELL DEATH 79 1472 6.16e-06 0.000252
115 MESONEPHROS DEVELOPMENT 13 90 6.388e-06 0.0002585
116 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 33 437 6.589e-06 0.0002641
117 HEAD DEVELOPMENT 46 709 6.64e-06 0.0002641
118 MORPHOGENESIS OF AN EPITHELIUM 31 400 7.46e-06 0.0002941
119 NEURON PROJECTION MORPHOGENESIS 31 402 8.243e-06 0.0003223
120 BIOLOGICAL ADHESION 60 1032 8.534e-06 0.0003309
121 SINGLE ORGANISM BEHAVIOR 30 384 8.931e-06 0.0003406
122 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 19 184 8.896e-06 0.0003406
123 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 18 168 9.148e-06 0.000346
124 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 65 1152 9.293e-06 0.0003487
125 RESPONSE TO FLUID SHEAR STRESS 8 34 1.001e-05 0.0003708
126 EMBRYONIC ORGAN DEVELOPMENT 31 406 1.004e-05 0.0003708
127 RESPONSE TO BMP 13 94 1.04e-05 0.0003781
128 CELLULAR RESPONSE TO BMP STIMULUS 13 94 1.04e-05 0.0003781
129 REGULATION OF ION TRANSPORT 40 592 1.049e-05 0.0003785
130 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 1.067e-05 0.0003788
131 PHOSPHORYLATION 68 1228 1.059e-05 0.0003788
132 ORGAN GROWTH 11 68 1.085e-05 0.0003826
133 POSITIVE REGULATION OF MAPK CASCADE 34 470 1.193e-05 0.0004141
134 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 34 470 1.193e-05 0.0004141
135 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 47 750 1.301e-05 0.0004459
136 POSITIVE REGULATION OF CELL DEVELOPMENT 34 472 1.303e-05 0.0004459
137 REGULATION OF CELL SUBSTRATE ADHESION 18 173 1.373e-05 0.0004663
138 GLAND MORPHOGENESIS 13 97 1.472e-05 0.0004965
139 RESPONSE TO GROWTH FACTOR 34 475 1.487e-05 0.0004978
140 HORMONE MEDIATED SIGNALING PATHWAY 17 158 1.525e-05 0.0005068
141 REGULATION OF LIPID METABOLIC PROCESS 24 282 1.748e-05 0.0005768
142 REGULATION OF GTPASE ACTIVITY 43 673 1.924e-05 0.0006305
143 REGULATION OF EPITHELIAL CELL PROLIFERATION 24 285 2.08e-05 0.0006751
144 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 97 1977 2.102e-05 0.0006751
145 EXTRACELLULAR STRUCTURE ORGANIZATION 25 304 2.104e-05 0.0006751
146 REGULATION OF METAL ION TRANSPORT 26 325 2.333e-05 0.0007437
147 CIRCULATORY SYSTEM PROCESS 28 366 2.585e-05 0.0008181
148 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 40 616 2.612e-05 0.000821
149 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 13 103 2.832e-05 0.0008843
150 REGULATION OF NEURON DIFFERENTIATION 37 554 2.883e-05 0.0008944
151 LYMPH VESSEL DEVELOPMENT 6 20 2.971e-05 0.0009154
152 NEURON DEVELOPMENT 43 687 3.132e-05 0.0009547
153 MORPHOGENESIS OF A BRANCHING STRUCTURE 17 167 3.139e-05 0.0009547
154 ENDOTHELIUM DEVELOPMENT 12 90 3.29e-05 0.0009878
155 REGULATION OF CELL MATRIX ADHESION 12 90 3.29e-05 0.0009878
156 NEGATIVE REGULATION OF CELL CYCLE 31 433 3.504e-05 0.001045
157 LYMPH VESSEL MORPHOGENESIS 5 13 3.645e-05 0.00108
158 REGULATION OF LIPID CATABOLIC PROCESS 9 52 3.938e-05 0.00116
159 REGULATION OF TRANSFERASE ACTIVITY 54 946 4.02e-05 0.001176
160 BONE MORPHOGENESIS 11 79 4.636e-05 0.00134
161 SKELETAL MUSCLE CELL DIFFERENTIATION 9 53 4.609e-05 0.00134
162 POSITIVE REGULATION OF HYDROLASE ACTIVITY 52 905 4.723e-05 0.001357
163 REGULATION OF GROWTH 40 633 4.789e-05 0.001367
164 KIDNEY EPITHELIUM DEVELOPMENT 14 125 5.449e-05 0.001546
165 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 5.519e-05 0.001547
166 POSITIVE REGULATION OF FATTY ACID OXIDATION 5 14 5.519e-05 0.001547
167 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 10 67 5.576e-05 0.001554
168 CELLULAR RESPONSE TO ACID CHEMICAL 17 175 5.697e-05 0.001559
169 TELENCEPHALON DEVELOPMENT 20 228 5.65e-05 0.001559
170 RESPONSE TO MECHANICAL STIMULUS 19 210 5.671e-05 0.001559
171 CARDIOCYTE DIFFERENTIATION 12 96 6.291e-05 0.001712
172 REGULATION OF CATABOLIC PROCESS 44 731 6.356e-05 0.001719
173 POSITIVE REGULATION OF NEURON DIFFERENTIATION 24 306 6.513e-05 0.001752
174 EYE DEVELOPMENT 25 326 6.65e-05 0.001778
175 COGNITION 21 251 7.384e-05 0.001963
176 NEGATIVE REGULATION OF MAPK CASCADE 15 145 7.526e-05 0.001976
177 SYSTEM PROCESS 87 1785 7.483e-05 0.001976
178 REGULATION OF STEM CELL DIFFERENTIATION 13 113 7.559e-05 0.001976
179 REGULATION OF VASCULATURE DEVELOPMENT 20 233 7.645e-05 0.001987
180 DENTATE GYRUS DEVELOPMENT 5 15 8.058e-05 0.002083
181 RESPONSE TO OXYGEN LEVELS 24 311 8.389e-05 0.002157
182 ENDOCHONDRAL BONE MORPHOGENESIS 8 45 8.684e-05 0.00222
183 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 26 352 8.892e-05 0.002261
184 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 34 9.102e-05 0.00228
185 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 9.102e-05 0.00228
186 CELL MATURATION 14 131 9.115e-05 0.00228
187 POSITIVE REGULATION OF CATABOLIC PROCESS 28 395 9.821e-05 0.002444
188 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 30 437 9.971e-05 0.002468
189 REGULATION OF EPITHELIAL CELL MIGRATION 16 166 0.0001025 0.002522
190 ENDOTHELIAL CELL DIFFERENTIATION 10 72 0.0001043 0.002554
191 POSITIVE REGULATION OF KINASE ACTIVITY 32 482 0.0001104 0.002688
192 FOREBRAIN DEVELOPMENT 26 357 0.0001118 0.002709
193 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 5 16 0.0001141 0.002751
194 REGULATION OF HYDROLASE ACTIVITY 68 1327 0.000117 0.002807
195 EPITHELIAL CELL DEVELOPMENT 17 186 0.0001214 0.002897
196 REGULATION OF MUSCLE CELL DIFFERENTIATION 15 152 0.0001285 0.00305
197 CARDIAC MUSCLE CELL DIFFERENTIATION 10 74 0.0001318 0.003114
198 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 7 36 0.0001335 0.003138
199 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 17 188 0.0001383 0.003202
200 PALLIUM DEVELOPMENT 15 153 0.0001383 0.003202
201 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 15 153 0.0001383 0.003202
202 RESPONSE TO ALCOHOL 26 362 0.0001398 0.00322
203 CELLULAR RESPONSE TO ABIOTIC STIMULUS 21 263 0.0001428 0.003274
204 RESPONSE TO PEPTIDE 28 404 0.0001437 0.003277
205 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 10 75 0.0001478 0.003338
206 SKELETAL MUSCLE ORGAN DEVELOPMENT 14 137 0.0001476 0.003338
207 CELL CYCLE ARREST 15 154 0.0001487 0.003343
208 SENSORY PERCEPTION OF MECHANICAL STIMULUS 15 155 0.0001598 0.003565
209 CARDIAC MUSCLE CELL ACTION POTENTIAL 7 37 0.0001601 0.003565
210 REGULATION OF CALCIUM ION TRANSPORT 18 209 0.000165 0.003655
211 STRIATED MUSCLE CELL DIFFERENTIATION 16 173 0.0001662 0.003664
212 CELL PROLIFERATION 40 672 0.0001719 0.003772
213 MULTICELLULAR ORGANISMAL SIGNALING 13 123 0.00018 0.003933
214 RESPONSE TO DRUG 29 431 0.0001825 0.003968
215 REGULATION OF CELLULAR COMPONENT BIOGENESIS 44 767 0.0001873 0.004054
216 CELL CELL ADHESION 37 608 0.0001944 0.004188
217 HEART MORPHOGENESIS 18 212 0.000197 0.004225
218 MULTICELLULAR ORGANISM METABOLIC PROCESS 11 93 0.0002078 0.004435
219 EAR DEVELOPMENT 17 195 0.0002148 0.004542
220 REGULATION OF MUSCLE SYSTEM PROCESS 17 195 0.0002148 0.004542
221 NEGATIVE REGULATION OF CALCIUM ION TRANSPORT 8 51 0.0002163 0.004553
222 NEURON PROJECTION DEVELOPMENT 34 545 0.000222 0.004653
223 NEGATIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 39 0.0002262 0.004677
224 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 0.0002262 0.004677
225 TRABECULA MORPHOGENESIS 7 39 0.0002262 0.004677
226 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 10 79 0.0002287 0.00468
227 REGULATION OF ACTIN FILAMENT BASED PROCESS 23 312 0.0002293 0.00468
228 ACTION POTENTIAL 11 94 0.0002286 0.00468
229 CELLULAR RESPONSE TO OXYGEN LEVELS 14 143 0.0002321 0.004715
230 EMBRYO DEVELOPMENT 49 894 0.0002402 0.004854
231 ANGIOGENESIS 22 293 0.000241 0.004854
232 CELLULAR RESPONSE TO PEPTIDE 21 274 0.0002509 0.005033
233 NEGATIVE REGULATION OF GROWTH 19 236 0.0002627 0.005247
234 REGULATION OF VASOCONSTRICTION 9 66 0.0002649 0.005266
235 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 337 0.0002824 0.005592
236 CARDIAC MUSCLE CELL CONTRACTION 6 29 0.0002839 0.005598
237 LYMPHANGIOGENESIS 4 11 0.0003004 0.005898
238 REGULATION OF CELLULAR RESPONSE TO STRESS 40 691 0.0003038 0.00594
239 REGULATION OF MAP KINASE ACTIVITY 23 319 0.0003152 0.006136
240 EMBRYONIC ORGAN MORPHOGENESIS 21 279 0.0003203 0.006209
241 REGULATION OF HEART CONTRACTION 18 221 0.0003283 0.006312
242 REGULATION OF ENDOTHELIAL CELL MIGRATION 12 114 0.000328 0.006312
243 DIGESTIVE SYSTEM DEVELOPMENT 14 148 0.0003314 0.006346
244 REGULATION OF TRANSMEMBRANE TRANSPORT 28 426 0.0003425 0.006531
245 RESPONSE TO AMPHETAMINE 6 30 0.0003453 0.006558
246 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 12 115 0.0003557 0.006698
247 POSITIVE REGULATION OF CELL PROLIFERATION 45 814 0.000357 0.006698
248 NEPHRON DEVELOPMENT 12 115 0.0003557 0.006698
249 SERTOLI CELL DIFFERENTIATION 5 20 0.0003636 0.006795
250 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 25 365 0.0003825 0.007119
251 REPRODUCTIVE SYSTEM DEVELOPMENT 27 408 0.0003907 0.007243
252 CELLULAR RESPONSE TO STARVATION 12 117 0.000417 0.007652
253 HEART PROCESS 10 85 0.0004177 0.007652
254 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 9 70 0.0004149 0.007652
255 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 31 498 0.0004306 0.007857
256 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 14 152 0.0004352 0.00791
257 L AMINO ACID IMPORT 4 12 0.0004391 0.00795
258 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 13 135 0.0004506 0.008102
259 PROTEIN LOCALIZATION 84 1805 0.000451 0.008102
260 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 10 86 0.0004592 0.008218
261 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 5 21 0.0004646 0.008252
262 NEGATIVE REGULATION OF NEURON DEATH 15 171 0.0004645 0.008252
263 CHEMICAL HOMEOSTASIS 47 874 0.0004872 0.00862
264 METANEPHRIC NEPHRON DEVELOPMENT 6 32 0.0004988 0.008791
265 REGULATION OF DEVELOPMENTAL GROWTH 21 289 0.0005107 0.008967
266 REGULATION OF CELL CYCLE 50 949 0.0005151 0.009011
267 CIRCADIAN RHYTHM 13 137 0.0005191 0.009046
268 REGULATION OF NEURON APOPTOTIC PROCESS 16 192 0.0005382 0.009319
269 GLAND DEVELOPMENT 26 395 0.0005388 0.009319
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 52 629 6.492e-10 6.031e-07
2 REGULATORY REGION NUCLEIC ACID BINDING 59 818 7.872e-09 3.657e-06
3 ENZYME BINDING 99 1737 1.89e-08 5.852e-06
4 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 12 48 2.895e-08 5.947e-06
5 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 75 1199 3.201e-08 5.947e-06
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 31 328 1.085e-07 1.679e-05
7 STEROID HORMONE RECEPTOR ACTIVITY 12 59 3.358e-07 4.456e-05
8 TRANSCRIPTION FACTOR BINDING 40 524 5.289e-07 6.142e-05
9 MACROMOLECULAR COMPLEX BINDING 78 1399 1.732e-06 0.0001788
10 KINASE ACTIVITY 53 842 3.171e-06 0.0002946
11 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 27 315 4.641e-06 0.0003919
12 PROTEIN DOMAIN SPECIFIC BINDING 42 624 6.934e-06 0.0005368
13 PROTEIN KINASE ACTIVITY 42 640 1.278e-05 0.0009136
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 21 226 1.57e-05 0.001042
15 KINASE BINDING 40 606 1.801e-05 0.001115
16 PROTEIN HOMODIMERIZATION ACTIVITY 45 722 2.274e-05 0.001243
17 IDENTICAL PROTEIN BINDING 66 1209 2.25e-05 0.001243
18 CYTOSKELETAL PROTEIN BINDING 49 819 2.85e-05 0.001452
19 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 6 20 2.971e-05 0.001452
20 CYTOKINE BINDING 12 92 4.11e-05 0.001735
21 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 12 92 4.11e-05 0.001735
22 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 56 992 3.918e-05 0.001735
23 GROWTH FACTOR BINDING 14 123 4.555e-05 0.00184
24 MAP KINASE KINASE KINASE ACTIVITY 6 22 5.41e-05 0.002094
25 PROTEIN DIMERIZATION ACTIVITY 62 1149 5.647e-05 0.002098
26 SEQUENCE SPECIFIC DNA BINDING 57 1037 6.933e-05 0.002477
27 DOUBLE STRANDED DNA BINDING 45 764 8.706e-05 0.002996
28 E BOX BINDING 7 34 9.102e-05 0.00302
29 PROTEIN SERINE THREONINE KINASE ACTIVITY 30 445 0.0001373 0.004399
30 RECEPTOR SIGNALING PROTEIN ACTIVITY 16 172 0.0001554 0.004811
31 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 19 228 0.0001688 0.005058
32 SIGNAL TRANSDUCER ACTIVITY 83 1731 0.0001905 0.005531
33 PROTEIN COMPLEX BINDING 51 935 0.0002018 0.00568
34 CALMODULIN BINDING 16 179 0.0002458 0.006717
35 TRANSCRIPTION COACTIVATOR BINDING 4 11 0.0003004 0.007973
36 RECEPTOR BINDING 72 1476 0.0003195 0.008244
37 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 15 168 0.0003847 0.009406
38 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 22 303 0.0003835 0.009406
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE MICRODOMAIN 30 288 1.982e-08 1.157e-05
2 CELL JUNCTION 72 1151 6.195e-08 1.262e-05
3 ANCHORING JUNCTION 40 489 8.646e-08 1.262e-05
4 MEMBRANE REGION 71 1134 7.453e-08 1.262e-05
5 CYTOSKELETON 101 1967 1.953e-06 0.0002281
6 CELL SUBSTRATE JUNCTION 32 398 2.467e-06 0.0002401
7 INTRINSIC COMPONENT OF PLASMA MEMBRANE 87 1649 3.898e-06 0.0003252
8 NEURON PART 70 1265 7.961e-06 0.0005811
9 NEURON PROJECTION 55 942 1.826e-05 0.001185
10 CELL PROJECTION 89 1786 2.728e-05 0.001593
11 PLASMA MEMBRANE REGION 53 929 4.813e-05 0.002555
12 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 5.519e-05 0.002686
13 CONTRACTILE FIBER 19 211 6.048e-05 0.002717
14 PLASMA MEMBRANE RAFT 11 86 0.0001023 0.004267
15 PROTEIN KINASE COMPLEX 11 90 0.0001548 0.005104
16 SODIUM CHANNEL COMPLEX 5 17 0.0001573 0.005104
17 MICROTUBULE PLUS END 5 17 0.0001573 0.005104
18 CELL CELL JUNCTION 27 383 0.0001424 0.005104
19 ACTIN CYTOSKELETON 29 444 0.0002998 0.008755
20 COATED PIT 9 67 0.0002973 0.008755
21 EXTRACELLULAR MATRIX 28 426 0.0003425 0.009377
22 SOMATODENDRITIC COMPARTMENT 38 650 0.0003532 0.009377

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 29 352 4.533e-06 0.0002357
2 TNF_signaling_pathway_hsa04668 14 108 1.03e-05 0.0002677
3 Focal_adhesion_hsa04510 17 199 0.0002732 0.004711
4 FoxO_signaling_pathway_hsa04068 13 132 0.0003624 0.004711
5 Adherens_junction_hsa04520 9 72 0.0005128 0.005167
6 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 0.0005961 0.005167
7 Jak_STAT_signaling_pathway_hsa04630 14 162 0.0008225 0.00611
8 Gap_junction_hsa04540 9 88 0.00218 0.01417
9 ECM_receptor_interaction_hsa04512 8 82 0.005046 0.0225
10 HIF_1_signaling_pathway_hsa04066 9 100 0.005163 0.0225
11 cAMP_signaling_pathway_hsa04024 14 198 0.005287 0.0225
12 TGF_beta_signaling_pathway_hsa04350 8 84 0.005836 0.0225
13 AMPK_signaling_pathway_hsa04152 10 121 0.006006 0.0225
14 p53_signaling_pathway_hsa04115 7 68 0.006361 0.0225
15 Calcium_signaling_pathway_hsa04020 13 182 0.006492 0.0225
16 MAPK_signaling_pathway_hsa04010 18 295 0.007905 0.02569
17 Hippo_signaling_pathway_hsa04390 11 154 0.01175 0.03594
18 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.01363 0.03778
19 Apelin_signaling_pathway_hsa04371 10 137 0.01381 0.03778
20 Sphingolipid_signaling_pathway_hsa04071 9 118 0.01461 0.03778
21 Cytokine_cytokine_receptor_interaction_hsa04060 16 270 0.01526 0.03778
22 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.01733 0.04095
23 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.01979 0.04475
24 Ras_signaling_pathway_hsa04014 13 232 0.03965 0.08591
25 Phospholipase_D_signaling_pathway_hsa04072 9 146 0.04833 0.1005
26 Autophagy_animal_hsa04140 8 128 0.05669 0.1107
27 mTOR_signaling_pathway_hsa04150 9 151 0.05747 0.1107
28 Cellular_senescence_hsa04218 9 160 0.07659 0.1374
29 Regulation_of_actin_cytoskeleton_hsa04810 11 208 0.0766 0.1374
30 NF_kappa_B_signaling_pathway_hsa04064 6 95 0.08813 0.1528
31 Tight_junction_hsa04530 9 170 0.1019 0.1615
32 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.1024 0.1615
33 Wnt_signaling_pathway_hsa04310 8 146 0.1025 0.1615
34 Oocyte_meiosis_hsa04114 7 124 0.1084 0.1658
35 Rap1_signaling_pathway_hsa04015 10 206 0.1334 0.1983
36 ErbB_signaling_pathway_hsa04012 5 85 0.1416 0.2046
37 Hedgehog_signaling_pathway_hsa04340 3 47 0.1947 0.2736
38 Endocytosis_hsa04144 10 244 0.2686 0.3676
39 Apoptosis_hsa04210 6 138 0.2903 0.3791
40 Neuroactive_ligand_receptor_interaction_hsa04080 11 278 0.292 0.3791
41 VEGF_signaling_pathway_hsa04370 3 59 0.2989 0.3791
42 ABC_transporters_hsa02010 2 45 0.4307 0.5333
43 Notch_signaling_pathway_hsa04330 2 48 0.4637 0.5607
44 Cell_cycle_hsa04110 4 124 0.5738 0.6782
45 Necroptosis_hsa04217 5 164 0.6171 0.7088
46 Mitophagy_animal_hsa04137 2 65 0.627 0.7088
47 Phagosome_hsa04145 4 152 0.7299 0.7774
48 Peroxisome_hsa04146 2 83 0.7551 0.7853
49 Lysosome_hsa04142 2 123 0.9116 0.9295

Quest ID: 8864178e3ecd0dba2115410376fe8421