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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-20a-5p ABHD2 0.85 0 -1.2 0 miRNATAP -0.28 0 NA
2 hsa-miR-20a-5p ABHD5 0.85 0 -0.6 0 MirTarget -0.12 1.0E-5 NA
3 hsa-miR-20a-5p ACER3 0.85 0 0.02 0.84604 mirMAP -0.12 2.0E-5 NA
4 hsa-miR-20a-5p ACOX1 0.85 0 -1.16 0 mirMAP -0.15 0.00046 NA
5 hsa-miR-20a-5p ACSL6 0.85 0 0.39 0.26458 mirMAP -0.21 0.03388 NA
6 hsa-miR-20a-5p ACTR3C 0.85 0 -0.99 0 mirMAP -0.21 1.0E-5 NA
7 hsa-miR-20a-5p ADAM9 0.85 0 0.47 0.00581 miRNATAP -0.24 0 NA
8 hsa-miR-20a-5p ADAMTS5 0.85 0 -0.16 0.36499 miRNATAP -0.16 0.00122 NA
9 hsa-miR-20a-5p ADARB1 0.85 0 -0.13 0.22208 MirTarget -0.11 0.00024 NA
10 hsa-miR-20a-5p ADRA2A 0.85 0 -0.76 0.02558 miRNATAP -0.4 2.0E-5 NA
11 hsa-miR-20a-5p AFF4 0.85 0 -0.64 0 miRNATAP -0.13 0 NA
12 hsa-miR-20a-5p AHRR 0.85 0 0.37 0.09373 MirTarget -0.13 0.04288 NA
13 hsa-miR-20a-5p AKAP13 0.85 0 -0.32 0.00142 MirTarget; mirMAP; miRNATAP -0.12 1.0E-5 NA
14 hsa-miR-20a-5p AKT3 0.85 0 -0.66 0.00047 miRNATAP -0.29 0 NA
15 hsa-miR-20a-5p AKTIP 0.85 0 -0.37 0.00054 MirTarget; miRNATAP -0.25 0 NA
16 hsa-miR-20a-5p ALDH1A3 0.85 0 -2.13 0 mirMAP -0.58 0 NA
17 hsa-miR-20a-5p ALDH3A2 0.85 0 -0.55 0.00022 mirMAP -0.1 0.01404 NA
18 hsa-miR-20a-5p ANKIB1 0.85 0 0.07 0.50551 miRNATAP -0.11 6.0E-5 NA
19 hsa-miR-20a-5p ANKRD29 0.85 0 1.13 4.0E-5 MirTarget -0.34 1.0E-5 NA
20 hsa-miR-20a-5p ANKRD50 0.85 0 -0.25 0.04433 MirTarget; miRNATAP -0.2 0 NA
21 hsa-miR-20a-5p ANO6 0.85 0 -0.29 0.00464 MirTarget -0.11 0.00024 NA
22 hsa-miR-20a-5p APBB2 0.85 0 -0.24 0.03085 MirTarget; miRNATAP -0.19 0 NA
23 hsa-miR-20a-5p APCDD1 0.85 0 -1.3 0.00043 MirTarget -0.34 0.00121 NA
24 hsa-miR-20a-5p AR 0.85 0 -2.66 0 mirMAP -0.73 0 NA
25 hsa-miR-20a-5p ARAP2 0.85 0 -1.13 0 MirTarget -0.21 1.0E-5 NA
26 hsa-miR-20a-5p ARHGAP23 0.85 0 -0.14 0.32985 mirMAP -0.18 2.0E-5 NA
27 hsa-miR-20a-5p ARHGAP24 0.85 0 -0.99 0 MirTarget -0.24 0 NA
28 hsa-miR-20a-5p ARL10 0.85 0 -0.42 0.01556 mirMAP -0.1 0.03875 NA
29 hsa-miR-20a-5p ARL13B 0.85 0 -0.32 0.01196 MirTarget -0.11 0.00134 NA
30 hsa-miR-20a-5p ARL4C 0.85 0 -0.83 1.0E-5 MirTarget; miRNATAP -0.11 0.04188 NA
31 hsa-miR-20a-5p ARSD 0.85 0 -1.16 0 mirMAP -0.33 0 NA
32 hsa-miR-20a-5p ASPA 0.85 0 -2.88 0 mirMAP -0.23 0.00712 NA
33 hsa-miR-20a-5p ATE1 0.85 0 -0.6 0.0009 MirTarget -0.11 0.02845 NA
34 hsa-miR-20a-5p ATL3 0.85 0 0.13 0.25255 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0 NA
35 hsa-miR-20a-5p ATP1A2 0.85 0 0.51 0.11121 MirTarget; miRNATAP -0.32 0.00041 NA
36 hsa-miR-20a-5p ATRX 0.85 0 -0.07 0.48759 mirMAP -0.13 0 NA
37 hsa-miR-20a-5p ATXN1L 0.85 0 0.09 0.38956 miRNATAP -0.13 0 NA
38 hsa-miR-20a-5p BBX 0.85 0 -0.07 0.54321 MirTarget; miRNATAP -0.18 0 NA
39 hsa-miR-20a-5p BCL2 0.85 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 NA
40 hsa-miR-20a-5p BHLHE41 0.85 0 -0.4 0.15906 miRNATAP -0.43 0 NA
41 hsa-miR-20a-5p BMPR2 0.85 0 -0.74 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.24 0 NA
42 hsa-miR-20a-5p BNC2 0.85 0 -0.39 0.08973 miRNATAP -0.36 0 NA
43 hsa-miR-20a-5p BNIP3L 0.85 0 -0.67 0 MirTarget -0.2 0 NA
44 hsa-miR-20a-5p BTN3A1 0.85 0 0.33 0.01478 miRNAWalker2 validate -0.21 0 NA
45 hsa-miR-20a-5p C16orf52 0.85 0 -0.5 0 miRNATAP -0.18 0 NA
46 hsa-miR-20a-5p C16orf70 0.85 0 -0.77 0 miRNATAP -0.11 0.00075 NA
47 hsa-miR-20a-5p C2CD2 0.85 0 0.04 0.76174 MirTarget; miRNATAP -0.19 0 NA
48 hsa-miR-20a-5p CA5B 0.85 0 0.77 1.0E-5 mirMAP -0.16 0.00143 NA
49 hsa-miR-20a-5p CALD1 0.85 0 -0.53 0 miRNATAP -0.2 0 NA
50 hsa-miR-20a-5p CAMTA2 0.85 0 -0.35 8.0E-5 MirTarget -0.11 1.0E-5 NA
51 hsa-miR-20a-5p CASC4 0.85 0 -0.46 0 MirTarget -0.19 0 NA
52 hsa-miR-20a-5p CASK 0.85 0 0.43 0.00011 mirMAP -0.2 0 NA
53 hsa-miR-20a-5p CAV1 0.85 0 0.18 0.17977 miRNATAP -0.17 0 NA
54 hsa-miR-20a-5p CAV2 0.85 0 -0.67 0.00155 mirMAP -0.33 0 NA
55 hsa-miR-20a-5p CBLN4 0.85 0 -1.67 0.00015 miRNATAP -0.55 1.0E-5 NA
56 hsa-miR-20a-5p CBX7 0.85 0 -0.08 0.52937 mirMAP -0.17 0 NA
57 hsa-miR-20a-5p CC2D1A 0.85 0 0.26 0.00869 MirTarget; miRNATAP -0.12 2.0E-5 NA
58 hsa-miR-20a-5p CCBE1 0.85 0 -5.46 0 mirMAP -0.64 0 NA
59 hsa-miR-20a-5p CCDC103 0.85 0 -0.03 0.84263 mirMAP -0.14 0.0048 NA
60 hsa-miR-20a-5p CCND1 0.85 0 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.33 0 NA
61 hsa-miR-20a-5p CCND2 0.85 0 0.36 0.03656 miRNAWalker2 validate; miRTarBase; miRNATAP -0.16 0.00121 NA
62 hsa-miR-20a-5p CD274 0.85 0 -1.27 0 MirTarget; miRNATAP -0.42 0 NA
63 hsa-miR-20a-5p CD69 0.85 0 -1.75 0 miRNATAP -0.22 0.00265 NA
64 hsa-miR-20a-5p CDC37L1 0.85 0 -1.68 0 MirTarget; miRNATAP -0.32 0 NA
65 hsa-miR-20a-5p CDK6 0.85 0 -0.31 0.22057 mirMAP -0.34 0 NA
66 hsa-miR-20a-5p CDKN1A 0.85 0 -0.77 6.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.28 0 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex
67 hsa-miR-20a-5p CELF2 0.85 0 -0.74 8.0E-5 miRNATAP -0.22 2.0E-5 NA
68 hsa-miR-20a-5p CEP97 0.85 0 0.29 0.07184 MirTarget; miRNATAP -0.12 0.00766 NA
69 hsa-miR-20a-5p CERCAM 0.85 0 -0.12 0.64816 MirTarget -0.19 0.00968 NA
70 hsa-miR-20a-5p CFL2 0.85 0 -1.18 0 MirTarget; miRNATAP -0.16 3.0E-5 NA
71 hsa-miR-20a-5p CHD9 0.85 0 -0.51 3.0E-5 MirTarget; miRNATAP -0.24 0 NA
72 hsa-miR-20a-5p CIITA 0.85 0 0.27 0.18011 mirMAP -0.19 0.00094 NA
73 hsa-miR-20a-5p CLIC6 0.85 0 -3.64 0 mirMAP -0.73 0 NA
74 hsa-miR-20a-5p CLIP4 0.85 0 -0.22 0.43954 MirTarget -0.3 0.00021 NA
75 hsa-miR-20a-5p CLOCK 0.85 0 -0.53 0.00745 MirTarget -0.28 0 NA
76 hsa-miR-20a-5p CMPK1 0.85 0 -0.68 0 MirTarget; miRNATAP -0.15 0 NA
77 hsa-miR-20a-5p CNDP1 0.85 0 -6.39 0 mirMAP -0.71 7.0E-5 NA
78 hsa-miR-20a-5p CNTNAP3 0.85 0 0.11 0.74285 MirTarget -0.36 7.0E-5 NA
79 hsa-miR-20a-5p COL1A1 0.85 0 0.83 0.00649 mirMAP -0.23 0.0068 NA
80 hsa-miR-20a-5p COL4A3 0.85 0 -0.93 0.00622 MirTarget; miRNATAP -0.28 0.00414 NA
81 hsa-miR-20a-5p COL8A2 0.85 0 -0.97 0.0009 mirMAP -0.23 0.00524 NA
82 hsa-miR-20a-5p CORO2B 0.85 0 -0.78 0.00171 MirTarget; miRNATAP -0.17 0.01392 NA
83 hsa-miR-20a-5p CPEB3 0.85 0 -2.74 0 miRNATAP -0.45 0 NA
84 hsa-miR-20a-5p CPEB4 0.85 0 -1.06 0 mirMAP -0.22 0 NA
85 hsa-miR-20a-5p CREB5 0.85 0 0 0.99313 MirTarget; miRNATAP -0.15 0.01025 NA
86 hsa-miR-20a-5p CRIM1 0.85 0 -0.43 0.03963 miRTarBase; MirTarget; miRNATAP -0.44 0 NA
87 hsa-miR-20a-5p CRK 0.85 0 -0.66 0 MirTarget; miRNATAP -0.12 5.0E-5 NA
88 hsa-miR-20a-5p CRYBG3 0.85 0 -0.7 0.01151 MirTarget; miRNATAP -0.48 0 NA
89 hsa-miR-20a-5p CSF1 0.85 0 -0.59 0.00153 miRNATAP -0.28 0 NA
90 hsa-miR-20a-5p CSGALNACT1 0.85 0 0.19 0.22912 MirTarget -0.21 0 NA
91 hsa-miR-20a-5p CXCL6 0.85 0 -3.43 0 MirTarget -0.84 0 NA
92 hsa-miR-20a-5p CXorf23 0.85 0 0.43 1.0E-5 mirMAP -0.1 0.00027 NA
93 hsa-miR-20a-5p CXorf38 0.85 0 -0.21 0.02517 mirMAP -0.13 0 NA
94 hsa-miR-20a-5p CYBRD1 0.85 0 -1.29 0 MirTarget -0.37 0 NA
95 hsa-miR-20a-5p CYP2U1 0.85 0 -1.02 0 MirTarget -0.33 0 NA
96 hsa-miR-20a-5p DAB2 0.85 0 -0.08 0.65939 MirTarget; miRNATAP -0.15 0.00404 NA
97 hsa-miR-20a-5p DAZAP2 0.85 0 -0.39 0 MirTarget; miRNATAP -0.11 0 NA
98 hsa-miR-20a-5p DCUN1D3 0.85 0 -1.25 0 MirTarget -0.16 0 NA
99 hsa-miR-20a-5p DGKE 0.85 0 -0.86 0 MirTarget -0.23 1.0E-5 NA
100 hsa-miR-20a-5p DIP2C 0.85 0 -0.78 5.0E-5 miRNATAP -0.25 0 NA
101 hsa-miR-20a-5p DIRC2 0.85 0 -0.06 0.49043 MirTarget; miRNATAP -0.22 0 NA
102 hsa-miR-20a-5p DIXDC1 0.85 0 -1.03 0 mirMAP -0.28 0 NA
103 hsa-miR-20a-5p DLC1 0.85 0 -1.42 0 miRNAWalker2 validate; miRNATAP -0.18 4.0E-5 NA
104 hsa-miR-20a-5p DLG2 0.85 0 -1.95 0 mirMAP -0.37 0 NA
105 hsa-miR-20a-5p DMD 0.85 0 -1.66 0 mirMAP -0.28 0 NA
106 hsa-miR-20a-5p DNAJB9 0.85 0 -0.63 0 miRNATAP -0.2 0 NA
107 hsa-miR-20a-5p DNAJC27 0.85 0 -0.35 0.00026 MirTarget; miRNATAP -0.14 0 NA
108 hsa-miR-20a-5p DOCK4 0.85 0 -0.2 0.07305 MirTarget -0.14 1.0E-5 NA
109 hsa-miR-20a-5p DPYSL2 0.85 0 -0.46 0.00089 MirTarget; miRNATAP -0.33 0 NA
110 hsa-miR-20a-5p DYNC1LI2 0.85 0 -0.06 0.41267 MirTarget; miRNATAP -0.12 0 NA
111 hsa-miR-20a-5p EDA2R 0.85 0 0.56 0.06663 MirTarget -0.35 4.0E-5 NA
112 hsa-miR-20a-5p EDEM1 0.85 0 -0.85 0 mirMAP -0.17 0 NA
113 hsa-miR-20a-5p EFNB1 0.85 0 -0.04 0.75638 miRNATAP -0.13 7.0E-5 NA
114 hsa-miR-20a-5p EGR2 0.85 0 -2.93 0 MirTarget; miRNATAP -0.39 0 23924943 Involvement of miR 20a in promoting gastric cancer progression by targeting early growth response 2 EGR2; Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression; Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a miR-20a was involved in the carcinogenesis of GC through modulation of the EGR2 signaling pathway
115 hsa-miR-20a-5p ELK3 0.85 0 -0.37 0.06773 MirTarget; miRNATAP -0.26 1.0E-5 NA
116 hsa-miR-20a-5p ELK4 0.85 0 0.24 0.02672 miRNATAP -0.13 1.0E-5 NA
117 hsa-miR-20a-5p EPAS1 0.85 0 -0.88 0 miRNATAP -0.13 2.0E-5 NA
118 hsa-miR-20a-5p EPHA4 0.85 0 -0.01 0.94622 miRNATAP -0.21 0.00021 NA
119 hsa-miR-20a-5p ERAP1 0.85 0 -0.06 0.66413 MirTarget -0.16 1.0E-5 NA
120 hsa-miR-20a-5p ESYT2 0.85 0 -0.17 0.03903 mirMAP -0.14 0 NA
121 hsa-miR-20a-5p ETV1 0.85 0 -0.47 0.05217 MirTarget; miRNATAP -0.24 0.00042 NA
122 hsa-miR-20a-5p F3 0.85 0 -1.78 0 MirTarget; miRNATAP -0.17 0.02735 NA
123 hsa-miR-20a-5p FAM129B 0.85 0 -0.13 0.41634 miRNATAP -0.15 0.00107 NA
124 hsa-miR-20a-5p FAM46C 0.85 0 -1.66 0 MirTarget; miRNATAP -0.24 0.00024 NA
125 hsa-miR-20a-5p FAT4 0.85 0 -1.89 0 MirTarget; miRNATAP -0.5 0 NA
126 hsa-miR-20a-5p FBXL5 0.85 0 -0.36 0.00059 miRNATAP -0.21 0 NA
127 hsa-miR-20a-5p FBXO28 0.85 0 -0.5 0 MirTarget; miRNATAP -0.13 0 NA
128 hsa-miR-20a-5p FBXO3 0.85 0 -0.54 0 miRNAWalker2 validate; mirMAP -0.13 0 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples
129 hsa-miR-20a-5p FBXO31 0.85 0 -0.1 0.57277 MirTarget -0.17 0.00046 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples
130 hsa-miR-20a-5p FEM1C 0.85 0 -0.5 0 MirTarget; miRNATAP -0.1 0.00025 NA
131 hsa-miR-20a-5p FGD4 0.85 0 -1.16 0 MirTarget -0.34 0 NA
132 hsa-miR-20a-5p FGD5 0.85 0 -0.09 0.58163 MirTarget; miRNATAP -0.12 0.00712 NA
133 hsa-miR-20a-5p FGF7 0.85 0 -0.65 0.00602 miRNAWalker2 validate -0.34 0 NA
134 hsa-miR-20a-5p FGFR1 0.85 0 -1.1 0 mirMAP -0.29 0 NA
135 hsa-miR-20a-5p FGL2 0.85 0 -1.57 0 MirTarget -0.3 0 NA
136 hsa-miR-20a-5p FHL2 0.85 0 -1.49 0 mirMAP -0.57 0 NA
137 hsa-miR-20a-5p FIBIN 0.85 0 -1.09 0.00125 MirTarget -0.38 7.0E-5 NA
138 hsa-miR-20a-5p FJX1 0.85 0 -0.06 0.72199 MirTarget; miRNATAP -0.16 0.00056 NA
139 hsa-miR-20a-5p FKBP5 0.85 0 -0.23 0.1942 mirMAP -0.23 0 NA
140 hsa-miR-20a-5p FLNA 0.85 0 0.23 0.20343 miRNAWalker2 validate -0.24 0 NA
141 hsa-miR-20a-5p FLT1 0.85 0 0.35 0.00776 MirTarget; miRNATAP -0.12 0.00085 NA
142 hsa-miR-20a-5p FMN1 0.85 0 -0.64 0.02771 mirMAP -0.4 0 NA
143 hsa-miR-20a-5p FNDC3A 0.85 0 -1 0 MirTarget; miRNATAP -0.16 3.0E-5 NA
144 hsa-miR-20a-5p FNIP2 0.85 0 -1.97 0 MirTarget -0.23 0.00283 NA
145 hsa-miR-20a-5p FOXJ2 0.85 0 0.02 0.81272 MirTarget; miRNATAP -0.11 3.0E-5 NA
146 hsa-miR-20a-5p FRMD6 0.85 0 -1.21 0 MirTarget; miRNATAP -0.28 0 NA
147 hsa-miR-20a-5p FTO 0.85 0 -0.23 0.00923 mirMAP -0.17 0 NA
148 hsa-miR-20a-5p FYCO1 0.85 0 -0.01 0.88337 MirTarget -0.19 0 NA
149 hsa-miR-20a-5p FYN 0.85 0 -1.06 0 miRNATAP -0.23 0 NA
150 hsa-miR-20a-5p FZD3 0.85 0 -0.43 0.07605 MirTarget; mirMAP; miRNATAP -0.26 0.00012 NA
NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 93 1518 9.586e-16 4.461e-12
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 92 1672 8.245e-13 1.918e-09
3 ORGAN MORPHOGENESIS 59 841 1.41e-12 2.187e-09
4 REGULATION OF CELL DIFFERENTIATION 84 1492 3.003e-12 2.795e-09
5 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 84 1492 3.003e-12 2.795e-09
6 REGULATION OF CELLULAR COMPONENT MOVEMENT 55 771 4.526e-12 3.51e-09
7 EPITHELIUM DEVELOPMENT 61 945 1.9e-11 1.263e-08
8 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 64 1036 3.745e-11 1.584e-08
9 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 64 1036 3.745e-11 1.584e-08
10 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 68 1135 3.303e-11 1.584e-08
11 REGULATION OF PHOSPHORUS METABOLIC PROCESS 86 1618 3.281e-11 1.584e-08
12 POSITIVE REGULATION OF MOLECULAR FUNCTION 91 1791 8.763e-11 3.137e-08
13 CELL DEVELOPMENT 78 1426 8.267e-11 3.137e-08
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 67 1142 1.158e-10 3.847e-08
15 POSITIVE REGULATION OF CATALYTIC ACTIVITY 80 1518 2.722e-10 8.444e-08
16 POSITIVE REGULATION OF CELL DEVELOPMENT 38 472 3.815e-10 1.044e-07
17 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 89 1784 3.771e-10 1.044e-07
18 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 61 1021 4.267e-10 1.103e-07
19 TUBE DEVELOPMENT 41 552 8.565e-10 1.985e-07
20 CARDIOVASCULAR SYSTEM DEVELOPMENT 51 788 8.958e-10 1.985e-07
21 CIRCULATORY SYSTEM DEVELOPMENT 51 788 8.958e-10 1.985e-07
22 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 39 513 1.163e-09 2.45e-07
23 REGULATION OF PROTEIN MODIFICATION PROCESS 85 1710 1.211e-09 2.45e-07
24 REGULATION OF KINASE ACTIVITY 50 776 1.54e-09 2.937e-07
25 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 54 876 1.578e-09 2.937e-07
26 POSITIVE REGULATION OF RESPONSE TO STIMULUS 92 1929 1.805e-09 3.23e-07
27 POSITIVE REGULATION OF CELL COMMUNICATION 78 1532 2.279e-09 3.928e-07
28 REGULATION OF CELL DEVELOPMENT 52 836 2.389e-09 3.97e-07
29 POSITIVE REGULATION OF LOCOMOTION 34 420 2.869e-09 4.604e-07
30 INTRACELLULAR SIGNAL TRANSDUCTION 79 1572 3.184e-09 4.939e-07
31 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 72 1395 5.903e-09 8.861e-07
32 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 81 1656 6.659e-09 9.683e-07
33 NEUROGENESIS 72 1402 7.271e-09 1.025e-06
34 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 34 437 7.835e-09 1.042e-06
35 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 47 740 7.733e-09 1.042e-06
36 POSITIVE REGULATION OF GENE EXPRESSION 83 1733 1.095e-08 1.415e-06
37 CELL PROJECTION ORGANIZATION 53 902 1.161e-08 1.46e-06
38 VASCULATURE DEVELOPMENT 35 469 1.362e-08 1.668e-06
39 POSITIVE REGULATION OF MAPK CASCADE 35 470 1.438e-08 1.715e-06
40 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 23 229 2.201e-08 2.407e-06
41 POSITIVE REGULATION OF NEURON DIFFERENTIATION 27 306 2.125e-08 2.407e-06
42 REGULATION OF TRANSFERASE ACTIVITY 54 946 2.225e-08 2.407e-06
43 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 30 368 2.133e-08 2.407e-06
44 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 1004 2.649e-08 2.739e-06
45 CENTRAL NERVOUS SYSTEM DEVELOPMENT 51 872 2.601e-08 2.739e-06
46 POSITIVE REGULATION OF KINASE ACTIVITY 35 482 2.709e-08 2.74e-06
47 TISSUE MORPHOGENESIS 37 533 3.472e-08 3.437e-06
48 NEURON PROJECTION MORPHOGENESIS 31 402 4.453e-08 4.317e-06
49 REGULATION OF MAPK CASCADE 42 660 4.784e-08 4.452e-06
50 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 34 470 4.714e-08 4.452e-06
51 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 43 689 5.712e-08 5.212e-06
52 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 83 1805 6.665e-08 5.964e-06
53 MUSCLE STRUCTURE DEVELOPMENT 32 432 6.859e-08 6.022e-06
54 CELLULAR COMPONENT MORPHOGENESIS 51 900 7.103e-08 6.121e-06
55 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 45 750 8.712e-08 7.37e-06
56 REGULATION OF NEURON DIFFERENTIATION 37 554 9.307e-08 7.733e-06
57 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 64 1275 1.272e-07 1.038e-05
58 MUSCLE TISSUE DEVELOPMENT 24 275 1.595e-07 1.258e-05
59 LOCOMOTION 58 1114 1.572e-07 1.258e-05
60 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 39 616 1.678e-07 1.301e-05
61 NEURON PROJECTION DEVELOPMENT 36 545 1.827e-07 1.371e-05
62 NEURON DIFFERENTIATION 49 874 1.799e-07 1.371e-05
63 POSITIVE REGULATION OF CELL DIFFERENTIATION 47 823 1.91e-07 1.389e-05
64 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 53 983 1.904e-07 1.389e-05
65 SKELETAL SYSTEM DEVELOPMENT 32 455 2.232e-07 1.598e-05
66 CYTOSKELETON ORGANIZATION 47 838 3.218e-07 2.269e-05
67 HEAD DEVELOPMENT 42 709 3.369e-07 2.34e-05
68 MORPHOGENESIS OF AN EPITHELIUM 29 400 4.451e-07 3.045e-05
69 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 21 232 5.209e-07 3.513e-05
70 ACTIN FILAMENT BASED PROCESS 31 450 5.412e-07 3.598e-05
71 RESPONSE TO ENDOGENOUS STIMULUS 68 1450 6.101e-07 3.998e-05
72 MUSCLE CELL DIFFERENTIATION 21 237 7.399e-07 4.782e-05
73 CELL PART MORPHOGENESIS 38 633 9.034e-07 5.72e-05
74 REGULATION OF CELL PROLIFERATION 69 1496 9.097e-07 5.72e-05
75 NEURON DEVELOPMENT 40 687 1.002e-06 6.216e-05
76 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 50 957 1.088e-06 6.663e-05
77 HEART DEVELOPMENT 31 466 1.139e-06 6.882e-05
78 TELENCEPHALON DEVELOPMENT 20 228 1.587e-06 9.465e-05
79 NEGATIVE REGULATION OF GENE EXPRESSION 68 1493 1.714e-06 0.000101
80 HEART MORPHOGENESIS 19 212 2.098e-06 0.000122
81 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 56 1152 2.263e-06 0.00013
82 BONE DEVELOPMENT 16 156 2.334e-06 0.0001325
83 REGULATION OF CELL PROJECTION ORGANIZATION 34 558 2.48e-06 0.000139
84 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 79 1848 2.622e-06 0.0001452
85 CARDIAC MUSCLE TISSUE DEVELOPMENT 15 140 2.792e-06 0.0001528
86 TRANSITION METAL ION HOMEOSTASIS 13 106 2.843e-06 0.0001538
87 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 43 801 3.239e-06 0.0001713
88 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 23 303 3.236e-06 0.0001713
89 NEGATIVE REGULATION OF CELL PROLIFERATION 37 643 3.384e-06 0.0001769
90 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 162 3.829e-06 0.000198
91 REGULATION OF HYDROLASE ACTIVITY 61 1327 4.657e-06 0.0002381
92 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 22 289 5.044e-06 0.0002551
93 FOREBRAIN DEVELOPMENT 25 357 5.128e-06 0.0002566
94 REGULATION OF CELL MORPHOGENESIS 33 552 5.223e-06 0.0002585
95 POSITIVE REGULATION OF CELL DEATH 35 605 5.565e-06 0.0002726
96 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 337 5.95e-06 0.0002884
97 REGULATION OF NEURON PROJECTION DEVELOPMENT 27 408 6.178e-06 0.0002964
98 GLAND MORPHOGENESIS 12 97 6.243e-06 0.0002964
99 BLOOD VESSEL MORPHOGENESIS 25 364 7.191e-06 0.000338
100 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 14 133 7.348e-06 0.0003401
101 PHOSPHORYLATION 57 1228 7.383e-06 0.0003401
102 REGULATION OF MAP KINASE ACTIVITY 23 319 7.59e-06 0.0003462
103 PROTEIN PHOSPHORYLATION 47 944 8.387e-06 0.0003789
104 STRIATED MUSCLE CELL DIFFERENTIATION 16 173 8.924e-06 0.0003955
105 REGULATION OF CELL SUBSTRATE ADHESION 16 173 8.924e-06 0.0003955
106 CELL MOTILITY 43 835 9.126e-06 0.0003969
107 LOCALIZATION OF CELL 43 835 9.126e-06 0.0003969
108 TUBE MORPHOGENESIS 23 323 9.3e-06 0.0004007
109 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 81 1977 9.543e-06 0.0004074
110 EPITHELIAL CELL DIFFERENTIATION 30 495 1.079e-05 0.0004564
111 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 12 103 1.167e-05 0.0004893
112 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 30 498 1.212e-05 0.0005035
113 REGULATION OF CELL ADHESION 35 629 1.284e-05 0.0005241
114 NEGATIVE REGULATION OF CELL COMMUNICATION 55 1192 1.28e-05 0.0005241
115 REGULATION OF CHEMOTAXIS 16 180 1.473e-05 0.0005959
116 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 26 404 1.493e-05 0.000599
117 REGULATION OF CELL DEATH 64 1472 1.574e-05 0.0006259
118 REGULATION OF CELL MATRIX ADHESION 11 90 1.703e-05 0.0006661
119 MESONEPHROS DEVELOPMENT 11 90 1.703e-05 0.0006661
120 KIDNEY EPITHELIUM DEVELOPMENT 13 125 1.767e-05 0.0006853
121 NEURON PROJECTION GUIDANCE 17 205 1.992e-05 0.0007661
122 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 48 1008 2.133e-05 0.0008135
123 EPITHELIAL CELL DEVELOPMENT 16 186 2.216e-05 0.0008382
124 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 17 207 2.258e-05 0.0008475
125 RESPONSE TO MECHANICAL STIMULUS 17 210 2.717e-05 0.001011
126 REGULATION OF VASCULATURE DEVELOPMENT 18 233 2.972e-05 0.001097
127 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 59 1360 3.708e-05 0.001358
128 NEGATIVE REGULATION OF CELL DIFFERENTIATION 33 609 3.841e-05 0.001391
129 BIOLOGICAL ADHESION 48 1032 3.856e-05 0.001391
130 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 64 1517 3.931e-05 0.001396
131 REGULATION OF BINDING 20 283 3.925e-05 0.001396
132 EMBRYONIC ORGAN DEVELOPMENT 25 406 4.501e-05 0.001587
133 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 724 4.577e-05 0.001589
134 ACTIVATION OF MAPKK ACTIVITY 8 52 4.555e-05 0.001589
135 EMBRYO DEVELOPMENT 43 894 4.62e-05 0.001592
136 TRABECULA MORPHOGENESIS 7 39 4.912e-05 0.001681
137 REGULATION OF OSSIFICATION 15 178 5.044e-05 0.001713
138 REGULATION OF DEVELOPMENTAL GROWTH 20 289 5.268e-05 0.001763
139 ORGAN GROWTH 9 68 5.256e-05 0.001763
140 POSITIVE REGULATION OF CELL PROLIFERATION 40 814 5.371e-05 0.001785
141 REGULATION OF JNK CASCADE 14 159 5.539e-05 0.001828
142 SKELETAL SYSTEM MORPHOGENESIS 16 201 5.698e-05 0.001867
143 IRON ION HOMEOSTASIS 9 69 5.911e-05 0.001923
144 TAXIS 27 464 5.958e-05 0.001925
145 POSITIVE REGULATION OF HYDROLASE ACTIVITY 43 905 6.111e-05 0.001961
146 CARDIAC CHAMBER MORPHOGENESIS 11 104 6.644e-05 0.002091
147 SENSORY ORGAN DEVELOPMENT 28 493 6.65e-05 0.002091
148 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 9 70 6.633e-05 0.002091
149 WOUND HEALING 27 470 7.396e-05 0.00231
150 CARDIAC CHAMBER DEVELOPMENT 13 144 7.854e-05 0.002436
151 UROGENITAL SYSTEM DEVELOPMENT 20 299 8.431e-05 0.002598
152 REGULATION OF EPITHELIAL CELL MIGRATION 14 166 8.843e-05 0.002689
153 RESPONSE TO GROWTH FACTOR 27 475 8.824e-05 0.002689
154 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 19 278 9.504e-05 0.002871
155 CARTILAGE DEVELOPMENT 13 147 9.699e-05 0.002912
156 EMBRYONIC ORGAN MORPHOGENESIS 19 279 9.964e-05 0.002972
157 CARDIAC MUSCLE CELL DIFFERENTIATION 9 74 0.0001031 0.003036
158 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 22 352 0.0001028 0.003036
159 EMBRYONIC HEMOPOIESIS 5 20 0.0001161 0.003376
160 RESPONSE TO WOUNDING 30 563 0.0001159 0.003376
161 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 11 111 0.0001203 0.003476
162 EMBRYONIC MORPHOGENESIS 29 539 0.0001273 0.003612
163 RESPONSE TO ABIOTIC STIMULUS 46 1024 0.0001268 0.003612
164 ENDOCHONDRAL BONE MORPHOGENESIS 7 45 0.0001271 0.003612
165 REGULATION OF EPITHELIAL CELL PROLIFERATION 19 285 0.0001316 0.003711
166 CONNECTIVE TISSUE DEVELOPMENT 15 194 0.0001335 0.003743
167 REGULATION OF BMP SIGNALING PATHWAY 9 77 0.0001407 0.00392
168 PALLIUM DEVELOPMENT 13 153 0.0001454 0.004027
169 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 5 21 0.0001492 0.004108
170 HOMEOSTASIS OF NUMBER OF CELLS 14 175 0.0001551 0.004246
171 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 15 197 0.0001582 0.00428
172 RESPIRATORY SYSTEM DEVELOPMENT 15 197 0.0001582 0.00428
173 CARDIOCYTE DIFFERENTIATION 10 96 0.0001609 0.004327
174 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 12 135 0.00017 0.004521
175 RESPONSE TO EXTERNAL STIMULUS 71 1821 0.0001697 0.004521
176 BONE MORPHOGENESIS 9 79 0.0001717 0.004538
177 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 13 156 0.0001765 0.004641
178 RESPONSE TO STEROID HORMONE 27 497 0.000185 0.004837
179 RESPONSE TO HORMONE 41 893 0.0001885 0.004901
180 REGULATION OF PROTEIN CATABOLIC PROCESS 23 393 0.0001905 0.004924
181 REGULATION OF LIPID KINASE ACTIVITY 7 48 0.0001932 0.004966
182 REGULATION OF HOMEOSTATIC PROCESS 25 447 0.0002049 0.005212
183 POSITIVE REGULATION OF CATABOLIC PROCESS 23 395 0.000205 0.005212
184 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 10 99 0.0002077 0.005224
185 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 10 99 0.0002077 0.005224
186 REGULATION OF BODY FLUID LEVELS 27 506 0.0002465 0.006165
187 REGULATION OF GTPASE ACTIVITY 33 673 0.0002513 0.006252
188 REGULATION OF CATABOLIC PROCESS 35 731 0.0002572 0.006365
189 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 11 121 0.0002587 0.006369
190 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 14 184 0.0002616 0.006404
191 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 6 36 0.0002629 0.006404
192 HOMEOSTATIC PROCESS 55 1337 0.0002695 0.006531
193 POSITIVE REGULATION OF MAP KINASE ACTIVITY 15 207 0.0002714 0.006543
194 REGULATION OF CELLULAR LOCALIZATION 53 1277 0.0002827 0.006781
195 RESPONSE TO DRUG 24 431 0.000291 0.006944
196 ACTIVATION OF PROTEIN KINASE ACTIVITY 18 279 0.000293 0.006957
197 CARDIAC SEPTUM DEVELOPMENT 9 85 0.0003004 0.007095
198 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 12 144 0.0003104 0.007279
199 NEGATIVE REGULATION OF CELL CYCLE 24 433 0.0003113 0.007279
200 REGULATION OF LIPID METABOLIC PROCESS 18 282 0.0003334 0.007757
201 CEREBRAL CORTEX DEVELOPMENT 10 105 0.0003361 0.00778
202 MORPHOGENESIS OF A BRANCHING STRUCTURE 13 167 0.0003447 0.007941
203 DEVELOPMENTAL GROWTH 20 333 0.0003524 0.008077
204 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 437 0.0003557 0.008113
205 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 7 53 0.0003627 0.008191
206 MESONEPHRIC TUBULE MORPHOGENESIS 7 53 0.0003627 0.008191
207 REGULATION OF PROTEIN BINDING 13 168 0.0003652 0.008209
208 REGULATION OF GROWTH 31 633 0.0003928 0.008787
209 POSITIVE REGULATION OF GROWTH 16 238 0.000399 0.008841
210 HEMOSTASIS 19 311 0.0003982 0.008841
211 VENTRICULAR SEPTUM DEVELOPMENT 7 54 0.0004077 0.00899
212 REGULATION OF ACTIN FILAMENT BASED PROCESS 19 312 0.0004143 0.009092
213 NEGATIVE REGULATION OF LOCOMOTION 17 263 0.0004187 0.009147
214 MUSCLE CELL DEVELOPMENT 11 128 0.0004209 0.009152
215 DEVELOPMENTAL MATURATION 14 193 0.0004255 0.009208
216 VENOUS BLOOD VESSEL DEVELOPMENT 4 15 0.000446 0.009607
217 REGULATION OF ANATOMICAL STRUCTURE SIZE 25 472 0.0004617 0.009853
218 ENDOTHELIUM DEVELOPMENT 9 90 0.0004609 0.009853
219 ENDOTHELIAL CELL DIFFERENTIATION 8 72 0.0004656 0.009892
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 90 1737 4.065e-11 3.776e-08
2 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 27 328 8.958e-08 4.161e-05
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 37 629 2.034e-06 0.0006298
4 MACROMOLECULAR COMPLEX BINDING 64 1399 3.106e-06 0.0007213
5 PROTEIN DOMAIN SPECIFIC BINDING 36 624 4.341e-06 0.0008066
6 CYTOSKELETAL PROTEIN BINDING 43 819 5.66e-06 0.0008189
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 23 315 6.17e-06 0.0008189
8 RECEPTOR BINDING 65 1476 8.94e-06 0.001038
9 KINASE ACTIVITY 43 842 1.119e-05 0.001152
10 TRANSCRIPTION FACTOR BINDING 31 524 1.24e-05 0.001152
11 KINASE BINDING 34 606 1.441e-05 0.001217
12 PROTEIN DIMERIZATION ACTIVITY 53 1149 1.875e-05 0.001413
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 18 226 1.977e-05 0.001413
14 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 47 992 2.957e-05 0.001962
15 RECEPTOR SIGNALING PROTEIN ACTIVITY 15 172 3.389e-05 0.002099
16 PROTEIN HOMODIMERIZATION ACTIVITY 37 722 4.319e-05 0.002508
17 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 53 1199 5.833e-05 0.003188
18 PROTEIN COMPLEX BINDING 44 935 6.261e-05 0.003231
19 PROTEIN KINASE ACTIVITY 33 640 9.962e-05 0.004871
20 MOLECULAR FUNCTION REGULATOR 57 1353 0.0001117 0.004979
21 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 10 92 0.0001125 0.004979
22 BINDING BRIDGING 14 173 0.0001374 0.005803
23 ACTIN BINDING 23 393 0.0001905 0.007373
24 MAP KINASE KINASE KINASE ACTIVITY 5 22 0.0001891 0.007373
25 CALCIUM ION BINDING 34 697 0.0002235 0.008305
26 GLYCOPROTEIN BINDING 10 101 0.0002449 0.00875
27 REGULATORY REGION NUCLEIC ACID BINDING 38 818 0.0002571 0.008846
28 EPHRIN RECEPTOR BINDING 5 24 0.0002927 0.009711
29 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 10 104 0.000311 0.009963
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE REGION 59 1134 1.245e-07 7.273e-05
2 MEMBRANE MICRODOMAIN 23 288 1.367e-06 0.000399
3 ACTIN CYTOSKELETON 28 444 1.026e-05 0.00112
4 CYTOSKELETON 81 1967 7.915e-06 0.00112
5 CELL SUBSTRATE JUNCTION 26 398 1.15e-05 0.00112
6 CELL LEADING EDGE 24 350 1.123e-05 0.00112
7 ANCHORING JUNCTION 29 489 2.259e-05 0.001885
8 PLASMA MEMBRANE REGION 44 929 5.395e-05 0.003938
9 PLASMA MEMBRANE RAFT 10 86 6.327e-05 0.004106
10 CELL JUNCTION 51 1151 7.626e-05 0.004454
11 PROTEIN KINASE COMPLEX 10 90 9.341e-05 0.004959
12 BASAL PLASMA MEMBRANE 6 33 0.0001594 0.006371
13 NEURON PROJECTION 43 942 0.0001492 0.006371
14 CELL PROJECTION 70 1786 0.0001625 0.006371
15 CELL PROJECTION PART 43 946 0.0001636 0.006371
16 NEURON PART 53 1265 0.000225 0.008211
17 BASAL PART OF CELL 7 51 0.0002845 0.009774

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 27 352 3.705e-07 1.4e-05
2 MAPK_signaling_pathway_hsa04010 24 295 5.778e-07 1.4e-05
3 Focal_adhesion_hsa04510 19 199 8.075e-07 1.4e-05
4 TNF_signaling_pathway_hsa04668 12 108 1.899e-05 0.0002468
5 Hippo_signaling_pathway_hsa04390 14 154 3.896e-05 0.0004052
6 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 5.449e-05 0.0004305
7 Cellular_senescence_hsa04218 14 160 5.932e-05 0.0004305
8 Jak_STAT_signaling_pathway_hsa04630 14 162 6.792e-05 0.0004305
9 Hippo_signaling_pathway_multiple_species_hsa04392 6 29 7.45e-05 0.0004305
10 FoxO_signaling_pathway_hsa04068 12 132 0.0001374 0.0007144
11 Rap1_signaling_pathway_hsa04015 15 206 0.0002576 0.001218
12 HIF_1_signaling_pathway_hsa04066 9 100 0.000994 0.004308
13 TGF_beta_signaling_pathway_hsa04350 8 84 0.001302 0.00521
14 p53_signaling_pathway_hsa04115 7 68 0.001647 0.006117
15 Endocytosis_hsa04144 14 244 0.003923 0.0136
16 Sphingolipid_signaling_pathway_hsa04071 8 118 0.01041 0.03383
17 AMPK_signaling_pathway_hsa04152 8 121 0.012 0.0367
18 Ras_signaling_pathway_hsa04014 12 232 0.01566 0.04524
19 Ferroptosis_hsa04216 4 40 0.01815 0.04966
20 ErbB_signaling_pathway_hsa04012 6 85 0.02094 0.05444
21 Tight_junction_hsa04530 9 170 0.02961 0.07332
22 Phospholipase_D_signaling_pathway_hsa04072 8 146 0.03279 0.0775
23 Cell_cycle_hsa04110 7 124 0.03866 0.08294
24 Oocyte_meiosis_hsa04114 7 124 0.03866 0.08294
25 Regulation_of_actin_cytoskeleton_hsa04810 10 208 0.03987 0.08294
26 ECM_receptor_interaction_hsa04512 5 82 0.05725 0.1145
27 Apoptosis_hsa04210 7 138 0.06203 0.1195
28 Cytokine_cytokine_receptor_interaction_hsa04060 11 270 0.08375 0.1555
29 mTOR_signaling_pathway_hsa04150 7 151 0.09008 0.1615
30 Autophagy_animal_hsa04140 6 128 0.1073 0.1844
31 Adherens_junction_hsa04520 4 72 0.11 0.1844
32 Hedgehog_signaling_pathway_hsa04340 3 47 0.1162 0.1888
33 cGMP_PKG_signaling_pathway_hsa04022 7 163 0.1213 0.1912
34 Wnt_signaling_pathway_hsa04310 6 146 0.167 0.2554
35 Gap_junction_hsa04540 4 88 0.1844 0.2719
36 VEGF_signaling_pathway_hsa04370 3 59 0.1882 0.2719
37 Apoptosis_multiple_species_hsa04215 2 33 0.2036 0.2861
38 Mitophagy_animal_hsa04137 3 65 0.2277 0.3116
39 cAMP_signaling_pathway_hsa04024 6 198 0.3875 0.5166
40 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.434 0.5643
41 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.4606 0.5842
42 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.5031 0.6229
43 Phagosome_hsa04145 4 152 0.5402 0.6533
44 Necroptosis_hsa04217 4 164 0.6003 0.7095
45 Peroxisome_hsa04146 2 83 0.6256 0.723
46 Calcium_signaling_pathway_hsa04020 4 182 0.6811 0.7699
47 Lysosome_hsa04142 2 123 0.8224 0.891
48 Apelin_signaling_pathway_hsa04371 2 137 0.8655 0.9185
49 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9937 1

Quest ID: 8a3720d72be6db304e19a16d0d7d21dc