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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-15b-5p AATK 0.25 0.79071 0 0.99243 MirTarget -0.22 0.04433 NA
2 hsa-miR-107 ABCA6 -0.29 0.76966 -0.01 0.98022 miRanda -0.39 0.00471 NA
3 hsa-miR-15b-5p ABCB5 0.25 0.79071 1.03 0.08206 MirTarget -0.37 0.02462 NA
4 hsa-miR-107 ABHD12B -0.29 0.76966 0.09 0.83255 miRanda -0.37 0.00148 NA
5 hsa-miR-107 ABHD13 -0.29 0.76966 0.09 0.82184 MirTarget; miRanda -0.11 0.00368 NA
6 hsa-miR-107 ABR -0.29 0.76966 -0.46 0.36774 miRanda -0.13 0.04074 NA
7 hsa-miR-222-3p ACACA -0.23 0.72665 -0.23 0.66735 miRNAWalker2 validate -0.1 0.00386 NA
8 hsa-miR-107 ACO1 -0.29 0.76966 0.01 0.982 miRanda -0.15 0.00127 NA
9 hsa-miR-107 ACTG2 -0.29 0.76966 0.62 0.28177 miRanda -0.33 0.02553 NA
10 hsa-miR-140-3p ACVR2B -0.11 0.90778 -0.14 0.74032 miRNAWalker2 validate; PITA; miRNATAP -0.12 0.02438 NA
11 hsa-miR-15b-5p ACVR2B 0.25 0.79071 -0.14 0.74032 miRNATAP -0.28 0 NA
12 hsa-miR-221-3p ADAM11 -0.26 0.74402 -0.51 0.14444 miRNATAP -0.3 0.00022 NA
13 hsa-miR-222-3p ADAM11 -0.23 0.72665 -0.51 0.14444 miRNATAP -0.26 0.00147 NA
14 hsa-miR-221-3p ADAM22 -0.26 0.74402 0.36 0.38733 MirTarget; miRNATAP -0.36 0.00015 NA
15 hsa-miR-222-3p ADAM22 -0.23 0.72665 0.36 0.38733 MirTarget; miRNATAP -0.34 0.00039 NA
16 hsa-miR-197-3p ADAMTS1 0.02 0.98197 -0.26 0.69609 miRNATAP -0.2 0.04534 NA
17 hsa-miR-27a-3p ADAMTS10 0.31 0.70372 -0.01 0.96987 MirTarget; miRNATAP -0.21 0.01318 NA
18 hsa-miR-15b-5p ADAMTS18 0.25 0.79071 -0.28 0.54902 miRNATAP -0.5 0.0005 NA
19 hsa-miR-107 ADAMTS19 -0.29 0.76966 -0.27 0.71187 miRanda -0.43 0.01932 NA
20 hsa-miR-148a-3p ADAMTS19 -0.32 0.74626 -0.27 0.71187 MirTarget -0.3 0.04059 NA
21 hsa-miR-15b-5p ADAMTS5 0.25 0.79071 -0 0.99654 miRNATAP -0.32 0.00415 NA
22 hsa-miR-221-3p ADAMTS6 -0.26 0.74402 0.13 0.72485 MirTarget -0.18 0.02985 NA
23 hsa-miR-222-3p ADAMTS6 -0.23 0.72665 0.13 0.72485 MirTarget -0.2 0.01296 NA
24 hsa-miR-107 ADAMTSL3 -0.29 0.76966 -0.04 0.93342 MirTarget; PITA; miRanda; miRNATAP -0.29 0.03386 NA
25 hsa-miR-150-5p ADCY1 -0.01 0.99407 -0.14 0.72935 mirMAP -0.2 0.00017 NA
26 hsa-miR-128-3p ADCY2 -0.04 0.95842 -0.16 0.81937 MirTarget -0.77 0.00034 NA
27 hsa-miR-148a-3p ADCY2 -0.32 0.74626 -0.16 0.81937 MirTarget; miRNATAP -0.47 0.00442 NA
28 hsa-miR-107 ADCYAP1 -0.29 0.76966 0.67 0.31207 MirTarget; PITA; miRanda; miRNATAP -0.63 0.00048 NA
29 hsa-miR-150-5p ADCYAP1R1 -0.01 0.99407 0.79 0.27302 mirMAP -0.5 0 NA
30 hsa-miR-150-5p ADRA2B -0.01 0.99407 -0.51 0.21804 mirMAP -0.2 0.00073 NA
31 hsa-miR-22-3p AGBL5 0.05 0.96778 0.09 0.87437 MirTarget; miRNATAP -0.16 1.0E-5 NA
32 hsa-miR-15b-5p AGPAT4 0.25 0.79071 -0.1 0.78351 mirMAP -0.31 2.0E-5 NA
33 hsa-miR-15b-5p AHCYL2 0.25 0.79071 -0 0.99112 miRNATAP -0.11 0.0129 NA
34 hsa-miR-15b-5p AHRR 0.25 0.79071 -0.45 0.15751 mirMAP -0.23 0.01086 NA
35 hsa-miR-128-3p AKR7A2 -0.04 0.95842 0.39 0.44612 MirTarget -0.12 0.00475 NA
36 hsa-miR-107 AKT3 -0.29 0.76966 0.09 0.82989 PITA; miRanda -0.29 0.00414 NA
37 hsa-miR-107 ALDH1A2 -0.29 0.76966 1.22 0.06977 miRanda -0.4 0.03794 NA
38 hsa-miR-27a-3p ALDH9A1 0.31 0.70372 0.05 0.93051 miRNAWalker2 validate -0.14 1.0E-5 NA
39 hsa-miR-150-5p ALS2CR12 -0.01 0.99407 -0.56 0.29016 MirTarget -0.24 0.00019 NA
40 hsa-miR-107 AMFR -0.29 0.76966 0.03 0.95365 miRanda -0.18 1.0E-5 NA
41 hsa-miR-150-5p AMIGO1 -0.01 0.99407 -0.26 0.36185 mirMAP -0.1 0.00023 NA
42 hsa-miR-222-3p AMMECR1 -0.23 0.72665 -0.14 0.77428 miRNATAP -0.11 0.01021 NA
43 hsa-miR-381-3p AMN1 0.27 0.56263 0.13 0.7629 MirTarget -0.15 0.00072 NA
44 hsa-miR-27a-3p AMOTL1 0.31 0.70372 0.66 0.21471 mirMAP -0.15 0.022 NA
45 hsa-miR-27a-3p ANK1 0.31 0.70372 -0.6 0.21009 miRNATAP -0.37 0.00265 NA
46 hsa-miR-15b-5p ANK2 0.25 0.79071 0.08 0.8625 MirTarget; miRNATAP -0.35 0.00362 NA
47 hsa-miR-107 ANKMY2 -0.29 0.76966 0.07 0.8533 miRanda -0.11 0.02675 NA
48 hsa-miR-15b-5p ANKRD13B 0.25 0.79071 0.02 0.94885 miRNATAP -0.25 0.00119 NA
49 hsa-miR-15b-5p ANKRD29 0.25 0.79071 0.38 0.25673 MirTarget -0.26 0.00947 NA
50 hsa-miR-15b-5p ANKRD46 0.25 0.79071 0.12 0.7754 MirTarget -0.17 0.00043 NA
51 hsa-miR-221-3p ANKRD52 -0.26 0.74402 -0.19 0.7473 miRNATAP -0.12 0.00053 NA
52 hsa-miR-222-3p ANKRD52 -0.23 0.72665 -0.19 0.7473 miRNATAP -0.15 2.0E-5 NA
53 hsa-miR-15b-5p ANKS1A 0.25 0.79071 -0.29 0.61184 MirTarget -0.16 0.00069 NA
54 hsa-miR-214-3p ANKS1B 0.03 0.95264 0.31 0.39938 miRNATAP -0.19 0.00081 NA
55 hsa-miR-148a-3p ANKS6 -0.32 0.74626 -0.03 0.94466 mirMAP -0.1 0.00503 NA
56 hsa-miR-107 ANTXR1 -0.29 0.76966 0.54 0.42797 miRanda -0.2 0.0116 NA
57 hsa-miR-660-5p ANTXR1 -0.56 0.13827 0.54 0.42797 mirMAP -0.13 0.00946 NA
58 hsa-miR-107 AP1S2 -0.29 0.76966 0.11 0.78352 PITA; miRanda -0.11 0.03941 NA
59 hsa-miR-107 AP2A1 -0.29 0.76966 -0.05 0.94157 miRanda -0.15 2.0E-5 NA
60 hsa-miR-15b-5p AP2A1 0.25 0.79071 -0.05 0.94157 miRNATAP -0.1 0.00481 NA
61 hsa-miR-107 APBA1 -0.29 0.76966 -0.01 0.97558 miRNATAP -0.22 0.00205 NA
62 hsa-miR-15b-5p APRT 0.25 0.79071 0.41 0.47976 miRNAWalker2 validate -0.12 0.0233 NA
63 hsa-miR-15b-5p AQP11 0.25 0.79071 -0.82 0.00192 MirTarget -0.41 0 NA
64 hsa-miR-27a-3p AQP11 0.31 0.70372 -0.82 0.00192 MirTarget; miRNATAP -0.23 0.00014 NA
65 hsa-miR-22-3p ARC 0.05 0.96778 -0.25 0.59666 mirMAP -0.31 0.00365 NA
66 hsa-miR-128-3p ARHGAP23 -0.04 0.95842 -0.19 0.77018 MirTarget -0.21 0.00446 NA
67 hsa-miR-107 ARHGAP24 -0.29 0.76966 0.11 0.72834 miRanda -0.18 0.01587 NA
68 hsa-miR-98-5p ARHGAP28 -0.05 0.91078 0.32 0.37736 miRNAWalker2 validate; MirTarget -0.22 0.00026 NA
69 hsa-miR-148a-3p ARHGEF17 -0.32 0.74626 -0.3 0.63774 miRNATAP -0.11 0.00677 NA
70 hsa-miR-15b-5p ARL2 0.25 0.79071 0.08 0.89102 MirTarget; miRNATAP -0.16 0.00137 NA
71 hsa-miR-140-3p ARL6IP1 -0.11 0.90778 -0.02 0.9733 miRNATAP -0.18 1.0E-5 NA
72 hsa-miR-139-5p ARMC2 -0.06 0.91481 -0.03 0.89811 MirTarget -0.11 0.03573 NA
73 hsa-miR-15b-5p ARMC5 0.25 0.79071 -0.11 0.76726 mirMAP; miRNATAP -0.16 4.0E-5 NA
74 hsa-miR-15b-5p ARVCF 0.25 0.79071 -0.63 0.1294 mirMAP -0.17 0.00576 NA
75 hsa-miR-27a-3p ARX 0.31 0.70372 -1.63 0.07012 miRNATAP -0.55 0.0191 NA
76 hsa-miR-214-3p ASF1B 0.03 0.95264 0.09 0.86181 miRNAWalker2 validate -0.11 0.00627 NA
77 hsa-miR-15b-5p ASTN1 0.25 0.79071 0.61 0.3113 MirTarget -0.36 0.04881 NA
78 hsa-miR-221-3p ASXL3 -0.26 0.74402 0.05 0.92639 miRNAWalker2 validate -0.29 0.02377 NA
79 hsa-miR-15b-5p ATF7IP2 0.25 0.79071 -0.19 0.5893 miRNATAP -0.16 0.01442 NA
80 hsa-miR-27a-3p ATOH7 0.31 0.70372 -0.44 0.3265 miRNATAP -0.39 9.0E-5 NA
81 hsa-miR-107 ATP11B -0.29 0.76966 0.04 0.93345 miRanda -0.18 8.0E-5 NA
82 hsa-miR-150-5p ATP1A2 -0.01 0.99407 0.82 0.16452 mirMAP -0.17 0.04551 NA
83 hsa-miR-222-3p ATP7B -0.23 0.72665 -0.1 0.82198 miRNAWalker2 validate -0.23 0.00012 NA
84 hsa-miR-27a-3p ATP7B 0.31 0.70372 -0.1 0.82198 miRNAWalker2 validate -0.17 0.00947 NA
85 hsa-miR-15b-5p ATXN7L1 0.25 0.79071 -0.07 0.85984 miRNATAP -0.14 0.00188 NA
86 hsa-miR-15b-5p ATXN7L2 0.25 0.79071 -0.31 0.35989 MirTarget; miRNATAP -0.14 0.00644 NA
87 hsa-miR-15b-5p ATXN7L3 0.25 0.79071 -0.17 0.74796 MirTarget; miRNATAP -0.12 0.00084 NA
88 hsa-miR-15b-5p ATXN7L3B 0.25 0.79071 0.07 0.91876 MirTarget -0.12 0.00587 NA
89 hsa-miR-363-3p B3GALT2 -0.19 0.72862 0.01 0.97201 MirTarget -0.13 0.00447 NA
90 hsa-miR-150-5p B4GALNT3 -0.01 0.99407 -0.48 0.31202 mirMAP -0.24 1.0E-5 NA
91 hsa-miR-27a-3p B4GALT3 0.31 0.70372 0.01 0.97921 MirTarget; miRNATAP -0.16 0 26987623 B4GALT3 up regulation by miR 27a contributes to the oncogenic activity in human cervical cancer cells; To explore the mechanism of dysregulation B4GALT3 was predicted to be a target of miR-27a; EGFP and pGL3-promoter reporter assay showed miR-27a binds to B4GALT3 3'UTR region but enhanced its expression; Furthermore shR-B4GALT3 counteracted the promotion of malignancies induced by miR-27a suggesting miR-27a upregulates B4GALT3 to enhance tumorigenic activities; Altogether our findings evidenced that B4GALT3 upregulated by miR-27a contributes to the tumorigenic activities by β1-integrin pathway and might provide potential biomarkers for cervical cancer
92 hsa-miR-148a-3p B4GALT5 -0.32 0.74626 0.15 0.83414 MirTarget; miRNATAP -0.13 9.0E-5 NA
93 hsa-miR-148a-3p BACH2 -0.32 0.74626 0 0.99992 MirTarget; miRNATAP -0.24 0.00258 NA
94 hsa-miR-15b-5p BACH2 0.25 0.79071 0 0.99992 MirTarget; miRNATAP -0.21 0.04831 NA
95 hsa-miR-15b-5p BAMBI 0.25 0.79071 0.04 0.93137 miRNAWalker2 validate -0.29 0.02082 NA
96 hsa-miR-107 BASP1 -0.29 0.76966 0.17 0.73896 miRanda -0.25 0.00948 NA
97 hsa-miR-15b-5p BCL2 0.25 0.79071 0 0.99871 miRNAWalker2 validate; miRTarBase -0.22 0.00768 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
98 hsa-miR-22-3p BCL9 0.05 0.96778 -0.05 0.93891 MirTarget; miRNATAP -0.13 0.00053 NA
99 hsa-miR-98-5p BEGAIN -0.05 0.91078 -0.06 0.86168 MirTarget -0.15 0.02941 NA
100 hsa-miR-15b-5p BEX1 0.25 0.79071 0.21 0.77313 miRNAWalker2 validate -0.58 0.01192 NA
101 hsa-miR-139-5p BICD1 -0.06 0.91481 -0.05 0.91735 miRanda -0.12 0.03466 NA
102 hsa-miR-221-3p BMF -0.26 0.74402 -0.04 0.93505 miRNAWalker2 validate; miRTarBase; miRNATAP -0.33 0 19671867 MicroRNA 221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality; This study aims to investigate the role of miR-221 in the modulation of Bmf a proapoptotic BH3-only protein and to characterize miR-221 contribution to hepatocarcinogenesis through modulation of apoptosis; Transfection of miR-221 and anti-miR-221 in HCC-derived cell lines and luciferase reporter assay were used to assess Bmf as a target of miR-221; Modulation of miR-221 and Bmf expression contributed to characterize their role in anoikis; Enforced miR-221 expression caused Bmf down-regulation whereas anti-miR-221 induced its up-regulation; A luciferase reporter assay confirmed Bmf as a target of miR-221; Our results indicate that miR-221 by targeting Bmf inhibits apoptosis
103 hsa-miR-222-3p BMF -0.23 0.72665 -0.04 0.93505 miRNATAP -0.32 0 NA
104 hsa-miR-148a-3p BMP3 -0.32 0.74626 -0.07 0.91081 MirTarget -0.34 0.02164 NA
105 hsa-miR-22-3p BMP7 0.05 0.96778 0.87 0.27108 miRNAWalker2 validate; miRTarBase -0.31 0.02757 NA
106 hsa-miR-150-5p BMPR1B -0.01 0.99407 -0.17 0.73205 MirTarget -0.14 0.0018 NA
107 hsa-miR-221-3p BNIP3 -0.26 0.74402 0.18 0.74746 miRNAWalker2 validate -0.16 0.00384 NA
108 hsa-miR-127-3p BOLA1 0.23 0.82211 0.09 0.81569 miRanda -0.12 0.00035 NA
109 hsa-miR-15b-5p BRSK2 0.25 0.79071 -0.33 0.54503 mirMAP -0.58 0.00054 NA
110 hsa-miR-22-3p BRSK2 0.05 0.96778 -0.33 0.54503 MirTarget; miRNATAP -0.3 0.01536 NA
111 hsa-miR-27a-3p BRSK2 0.31 0.70372 -0.33 0.54503 MirTarget; miRNATAP -0.45 0.00152 NA
112 hsa-miR-222-3p BRWD3 -0.23 0.72665 -0.32 0.3362 MirTarget; miRNATAP -0.13 0.00276 NA
113 hsa-miR-15b-5p BTBD19 0.25 0.79071 -0.16 0.65017 mirMAP -0.47 1.0E-5 NA
114 hsa-miR-221-3p BTBD3 -0.26 0.74402 -0.1 0.84572 miRNATAP -0.16 4.0E-5 NA
115 hsa-miR-222-3p BTBD3 -0.23 0.72665 -0.1 0.84572 miRNATAP -0.18 0 NA
116 hsa-miR-22-3p BTF3 0.05 0.96778 0.26 0.72879 miRNAWalker2 validate -0.22 0 NA
117 hsa-miR-15b-5p BTG2 0.25 0.79071 0.12 0.85326 MirTarget; miRNATAP -0.15 0.02555 NA
118 hsa-miR-139-5p BTN3A1 -0.06 0.91481 -0.2 0.68933 miRanda -0.13 0.00553 NA
119 hsa-miR-15b-5p BTRC 0.25 0.79071 0.11 0.79104 MirTarget; miRNATAP -0.13 0.00038 NA
120 hsa-miR-660-5p BVES -0.56 0.13827 -0.21 0.59977 miRNATAP -0.2 0.00606 NA
121 hsa-miR-98-5p C10orf105 -0.05 0.91078 -0.14 0.67815 mirMAP -0.17 0.01213 NA
122 hsa-miR-197-3p C11orf45 0.02 0.98197 0.15 0.61304 mirMAP -0.13 0.04078 NA
123 hsa-miR-27a-3p C1orf21 0.31 0.70372 0.37 0.41244 mirMAP; miRNATAP -0.18 0.00754 NA
124 hsa-miR-150-5p C3orf18 -0.01 0.99407 -0.03 0.93313 miRNATAP -0.1 6.0E-5 NA
125 hsa-miR-107 C5 -0.29 0.76966 -0.01 0.97777 miRanda -0.21 0.02673 NA
126 hsa-miR-107 C9orf69 -0.29 0.76966 -0.03 0.95695 PITA; miRNATAP -0.12 0.00139 NA
127 hsa-miR-140-3p CABLES1 -0.11 0.90778 0.18 0.73371 MirTarget -0.12 0.04466 NA
128 hsa-miR-140-3p CABLES2 -0.11 0.90778 -0.07 0.89154 miRNATAP -0.1 0.02075 NA
129 hsa-miR-27a-3p CABP1 0.31 0.70372 0.03 0.93615 miRNATAP -0.24 0.00482 NA
130 hsa-miR-221-3p CABYR -0.26 0.74402 -0.16 0.63234 miRNAWalker2 validate; miRNATAP -0.23 0.00033 NA
131 hsa-miR-222-3p CABYR -0.23 0.72665 -0.16 0.63234 miRNAWalker2 validate; miRNATAP -0.24 0.00012 NA
132 hsa-miR-107 CACNA1C -0.29 0.76966 0.32 0.38287 miRNATAP -0.22 0.02785 NA
133 hsa-miR-150-5p CACNA1D -0.01 0.99407 0.35 0.34276 MirTarget -0.17 0.00062 NA
134 hsa-miR-363-3p CACNA1I -0.19 0.72862 -0.25 0.61966 MirTarget -0.22 0.00148 NA
135 hsa-miR-27a-3p CACNB2 0.31 0.70372 -0.31 0.17331 MirTarget; miRNATAP -0.16 0.00525 NA
136 hsa-miR-221-3p CACNB4 -0.26 0.74402 0.1 0.73607 miRNATAP -0.22 0.00156 NA
137 hsa-miR-222-3p CACNB4 -0.23 0.72665 0.1 0.73607 miRNATAP -0.25 0.00018 NA
138 hsa-miR-148a-3p CADM1 -0.32 0.74626 0.62 0.29136 MirTarget -0.13 0.02073 NA
139 hsa-miR-363-3p CADM2 -0.19 0.72862 0.04 0.96269 MirTarget; mirMAP -0.32 0.00125 NA
140 hsa-miR-98-5p CADM2 -0.05 0.91078 0.04 0.96269 MirTarget -0.46 0.00085 NA
141 hsa-miR-107 CALD1 -0.29 0.76966 0.41 0.56714 miRanda -0.17 0.00864 NA
142 hsa-miR-27a-3p CALM3 0.31 0.70372 -0 0.9978 miRNATAP -0.13 0.00023 NA
143 hsa-miR-140-3p CAMK2B -0.11 0.90778 -0.11 0.81595 mirMAP -0.37 0.00393 NA
144 hsa-miR-150-5p CAMK2B -0.01 0.99407 -0.11 0.81595 mirMAP -0.26 5.0E-5 NA
145 hsa-miR-107 CAMKK1 -0.29 0.76966 -0.61 0.05939 miRNATAP -0.16 0.02491 NA
146 hsa-miR-15b-5p CAMKV 0.25 0.79071 -0.04 0.95823 miRNATAP -0.5 0.00564 NA
147 hsa-miR-127-3p CAMTA1 0.23 0.82211 0.04 0.93207 miRanda -0.12 2.0E-5 NA
148 hsa-miR-221-3p CAMTA1 -0.26 0.74402 0.04 0.93207 MirTarget -0.11 0.00197 NA
149 hsa-miR-107 CAPN2 -0.29 0.76966 -0.22 0.75885 miRanda -0.16 0.00224 NA
150 hsa-miR-150-5p CAPN6 -0.01 0.99407 0.27 0.68775 miRNATAP -0.19 0.04415 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF GENE EXPRESSION 171 1733 2.358e-13 4.516e-10
2 NEUROGENESIS 146 1402 2.912e-13 4.516e-10
3 CENTRAL NERVOUS SYSTEM DEVELOPMENT 105 872 1.413e-13 4.516e-10
4 REGULATION OF NEURON DIFFERENTIATION 76 554 6.714e-13 7.81e-10
5 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 170 1805 1.418e-11 1.32e-08
6 HEAD DEVELOPMENT 85 709 4.285e-11 3.323e-08
7 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 88 750 5.975e-11 3.479e-08
8 RESPONSE TO ENDOGENOUS STIMULUS 142 1450 5.981e-11 3.479e-08
9 REGULATION OF CELL DIFFERENTIATION 143 1492 2.312e-10 9.78e-08
10 UROGENITAL SYSTEM DEVELOPMENT 47 299 1.966e-10 9.78e-08
11 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 164 1784 2.259e-10 9.78e-08
12 FOREBRAIN DEVELOPMENT 52 357 3.668e-10 1.422e-07
13 NEGATIVE REGULATION OF CELL DIFFERENTIATION 74 609 4.449e-10 1.592e-07
14 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 105 1004 6.923e-10 2.301e-07
15 REGULATION OF CELL DEVELOPMENT 91 836 1.411e-09 4.378e-07
16 CELL DEVELOPMENT 135 1426 1.756e-09 5.106e-07
17 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 30 153 2.041e-09 5.585e-07
18 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 152 1672 2.499e-09 6.46e-07
19 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 103 1008 3.583e-09 8.775e-07
20 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 35 204 3.987e-09 9.275e-07
21 PROTEIN LOCALIZATION TO MEMBRANE 51 376 6.523e-09 1.445e-06
22 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 25 118 8.635e-09 1.747e-06
23 TISSUE DEVELOPMENT 139 1518 8.433e-09 1.747e-06
24 NEURON DIFFERENTIATION 91 874 1.263e-08 2.448e-06
25 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 85 801 1.647e-08 2.838e-06
26 CARDIOVASCULAR SYSTEM DEVELOPMENT 84 788 1.634e-08 2.838e-06
27 CIRCULATORY SYSTEM DEVELOPMENT 84 788 1.634e-08 2.838e-06
28 MULTICELLULAR ORGANISMAL SIGNALING 25 123 2.091e-08 3.475e-06
29 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 61 513 3.479e-08 5.581e-06
30 EMBRYO DEVELOPMENT 91 894 3.698e-08 5.735e-06
31 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 39 264 3.935e-08 5.906e-06
32 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 63 541 4.53e-08 6.358e-06
33 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 63 541 4.53e-08 6.358e-06
34 BIOLOGICAL ADHESION 101 1032 4.646e-08 6.358e-06
35 CELLULAR COMPONENT MORPHOGENESIS 91 900 5.053e-08 6.717e-06
36 PROTEIN TARGETING TO MEMBRANE 28 157 6.009e-08 7.767e-06
37 CELL CELL ADHESION 68 608 6.441e-08 8.1e-06
38 ORGAN MORPHOGENESIS 86 841 7.268e-08 8.899e-06
39 APPENDAGE DEVELOPMENT 29 169 8.411e-08 9.785e-06
40 LIMB DEVELOPMENT 29 169 8.411e-08 9.785e-06
41 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 108 1142 9.134e-08 1.037e-05
42 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 38 262 9.58e-08 1.061e-05
43 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 99 1021 9.977e-08 1.08e-05
44 NEGATIVE REGULATION OF PHOSPHORYLATION 52 422 1.152e-07 1.218e-05
45 KIDNEY EPITHELIUM DEVELOPMENT 24 125 1.247e-07 1.289e-05
46 REGULATION OF PHOSPHORUS METABOLIC PROCESS 141 1618 1.378e-07 1.394e-05
47 REGULATION OF PROTEIN MODIFICATION PROCESS 147 1710 1.654e-07 1.638e-05
48 RESPONSE TO GROWTH FACTOR 56 475 1.691e-07 1.639e-05
49 REGULATION OF SYSTEM PROCESS 58 507 2.843e-07 2.646e-05
50 REGULATION OF BLOOD CIRCULATION 40 295 2.792e-07 2.646e-05
51 NEURON PROJECTION DEVELOPMENT 61 545 3.007e-07 2.743e-05
52 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 21 104 3.124e-07 2.795e-05
53 REGULATION OF TRANSPORT 152 1804 3.395e-07 2.98e-05
54 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 72 689 3.832e-07 3.302e-05
55 EPITHELIUM DEVELOPMENT 91 945 4.563e-07 3.725e-05
56 EMBRYONIC MORPHOGENESIS 60 539 4.527e-07 3.725e-05
57 TUBE MORPHOGENESIS 42 323 4.495e-07 3.725e-05
58 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 66 616 4.864e-07 3.902e-05
59 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 61 554 5.278e-07 4.162e-05
60 INTRACELLULAR SIGNAL TRANSDUCTION 135 1572 5.97e-07 4.63e-05
61 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 54 470 6.374e-07 4.862e-05
62 TISSUE MORPHOGENESIS 59 533 6.801e-07 4.868e-05
63 TRANSLATIONAL INITIATION 25 146 6.726e-07 4.868e-05
64 REGULATION OF CELL PROJECTION ORGANIZATION 61 558 6.738e-07 4.868e-05
65 NEGATIVE REGULATION OF CELL DEATH 85 872 6.711e-07 4.868e-05
66 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 33 229 7.643e-07 5.333e-05
67 MORPHOGENESIS OF AN EPITHELIUM 48 400 7.679e-07 5.333e-05
68 REGULATION OF HEART CONTRACTION 32 221 1.005e-06 6.88e-05
69 REGULATION OF WNT SIGNALING PATHWAY 40 310 1.025e-06 6.912e-05
70 REGULATION OF CELL DEATH 127 1472 1.049e-06 6.976e-05
71 HEART DEVELOPMENT 53 466 1.104e-06 7.196e-05
72 REGIONALIZATION 40 311 1.113e-06 7.196e-05
73 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 29 191 1.198e-06 7.638e-05
74 NEGATIVE REGULATION OF CELL DEVELOPMENT 39 303 1.484e-06 9.163e-05
75 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 22 123 1.458e-06 9.163e-05
76 PROTEIN PHOSPHORYLATION 89 944 1.497e-06 9.163e-05
77 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 50 437 1.862e-06 0.0001125
78 POSITIVE REGULATION OF NEURON DIFFERENTIATION 39 306 1.897e-06 0.0001132
79 TUBE DEVELOPMENT 59 552 2.126e-06 0.0001252
80 REGULATION OF ORGANELLE ORGANIZATION 105 1178 2.302e-06 0.0001339
81 REGULATION OF CELL PROLIFERATION 127 1496 2.412e-06 0.0001386
82 MESONEPHROS DEVELOPMENT 18 90 2.487e-06 0.0001411
83 MULTI ORGANISM METABOLIC PROCESS 23 138 3.002e-06 0.0001672
84 POSITIVE REGULATION OF CELL DIFFERENTIATION 79 823 3.018e-06 0.0001672
85 REGULATION OF NEURON PROJECTION DEVELOPMENT 47 408 3.13e-06 0.0001714
86 REGULATION OF CELLULAR LOCALIZATION 111 1277 3.774e-06 0.0002023
87 CELLULAR MACROMOLECULE LOCALIZATION 108 1234 3.783e-06 0.0002023
88 NEURON DEVELOPMENT 68 687 5.364e-06 0.0002836
89 SENSORY ORGAN DEVELOPMENT 53 493 5.892e-06 0.000308
90 PATTERN SPECIFICATION PROCESS 47 418 6.038e-06 0.0003122
91 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 29 207 6.187e-06 0.0003164
92 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 59 573 6.845e-06 0.0003462
93 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 101 1152 7.368e-06 0.0003686
94 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 18 97 7.565e-06 0.0003745
95 MORPHOGENESIS OF A BRANCHING STRUCTURE 25 167 8.25e-06 0.0004041
96 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 148 1848 8.499e-06 0.0004119
97 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 135 1656 9.246e-06 0.0004435
98 REGULATION OF CELLULAR COMPONENT BIOGENESIS 73 767 9.664e-06 0.0004561
99 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 109 1275 9.72e-06 0.0004561
100 STEM CELL DIFFERENTIATION 27 190 9.803e-06 0.0004561
101 HEART MORPHOGENESIS 29 212 9.904e-06 0.0004563
102 RESPONSE TO HORMONE 82 893 1.052e-05 0.000475
103 NEURON PROJECTION MORPHOGENESIS 45 402 1.062e-05 0.000475
104 BEHAVIOR 54 516 1.052e-05 0.000475
105 POSITIVE REGULATION OF CELL COMMUNICATION 126 1532 1.247e-05 0.0005452
106 SKELETAL SYSTEM DEVELOPMENT 49 455 1.254e-05 0.0005452
107 CARDIAC CONDUCTION 16 82 1.238e-05 0.0005452
108 RNA CATABOLIC PROCESS 30 227 1.394e-05 0.0006006
109 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 86 957 1.451e-05 0.0006136
110 REGULATION OF KINASE ACTIVITY 73 776 1.439e-05 0.0006136
111 POSITIVE REGULATION OF CELL DEVELOPMENT 50 472 1.602e-05 0.0006715
112 REGULATION OF TRANSFERASE ACTIVITY 85 946 1.636e-05 0.0006797
113 POSITIVE REGULATION OF CELL DEATH 60 605 1.801e-05 0.0007414
114 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 35 289 1.924e-05 0.0007718
115 RESPIRATORY SYSTEM DEVELOPMENT 27 197 1.913e-05 0.0007718
116 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 28 208 1.893e-05 0.0007718
117 REGULATION OF INTRACELLULAR TRANSPORT 61 621 2.049e-05 0.000815
118 MEMBRANE ORGANIZATION 81 899 2.353e-05 0.0009277
119 REGULATION OF CYTOPLASMIC TRANSPORT 50 481 2.646e-05 0.001026
120 CELL PROJECTION ORGANIZATION 81 902 2.646e-05 0.001026
121 SOMITE DEVELOPMENT 15 78 2.754e-05 0.001059
122 HINDBRAIN DEVELOPMENT 21 137 2.968e-05 0.001132
123 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 123 1517 3.057e-05 0.001156
124 RHYTHMIC PROCESS 35 298 3.681e-05 0.001381
125 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 112 1360 3.711e-05 0.001381
126 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 86 983 3.87e-05 0.001429
127 TELENCEPHALON DEVELOPMENT 29 228 3.959e-05 0.00145
128 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 93 1087 4.362e-05 0.001586
129 REGULATION OF TRANSMEMBRANE TRANSPORT 45 426 4.487e-05 0.001618
130 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 20 131 4.829e-05 0.001728
131 POSITIVE REGULATION OF MOLECULAR FUNCTION 140 1791 5.004e-05 0.001777
132 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 35 303 5.196e-05 0.001832
133 REGULATION OF PROTEIN LOCALIZATION 83 950 5.538e-05 0.001937
134 NEGATIVE REGULATION OF CELL PROLIFERATION 61 643 5.687e-05 0.001975
135 PHOSPHORYLATION 102 1228 6.013e-05 0.002073
136 NEGATIVE REGULATION OF TRANSPORT 47 458 6.277e-05 0.002148
137 REGULATION OF MUSCLE TISSUE DEVELOPMENT 17 103 6.457e-05 0.002193
138 MESENCHYMAL CELL DIFFERENTIATION 20 134 6.7e-05 0.002238
139 CELLULAR RESPONSE TO HORMONE STIMULUS 54 552 6.734e-05 0.002238
140 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 14 6.638e-05 0.002238
141 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 113 1395 6.817e-05 0.00225
142 SOMATIC STEM CELL POPULATION MAINTENANCE 13 66 7.19e-05 0.002323
143 ACTION POTENTIAL 16 94 7.18e-05 0.002323
144 NEURAL TUBE FORMATION 16 94 7.18e-05 0.002323
145 SINGLE ORGANISM BEHAVIOR 41 384 7.596e-05 0.002437
146 RESPONSE TO ESTRADIOL 21 146 7.72e-05 0.00246
147 NEPHRON DEVELOPMENT 18 115 8.15e-05 0.00258
148 SPINAL CORD DEVELOPMENT 17 106 9.346e-05 0.002938
149 INTRACELLULAR PROTEIN TRANSPORT 70 781 9.855e-05 0.003078
150 GLAND MORPHOGENESIS 16 97 0.0001058 0.003161
151 SECOND MESSENGER MEDIATED SIGNALING 22 160 0.0001043 0.003161
152 ANTERIOR POSTERIOR PATTERN SPECIFICATION 25 194 0.0001065 0.003161
153 REGULATION OF SYNAPTIC VESICLE EXOCYTOSIS 7 21 0.0001064 0.003161
154 EYE DEVELOPMENT 36 326 0.0001037 0.003161
155 CONNECTIVE TISSUE DEVELOPMENT 25 194 0.0001065 0.003161
156 PROTEIN LOCALIZATION 139 1805 0.0001067 0.003161
157 NEURON PROJECTION GUIDANCE 26 205 0.0001021 0.003161
158 REGULATION OF GLYCOGEN METABOLIC PROCESS 9 35 0.0001084 0.003193
159 CELL PROLIFERATION 62 672 0.0001098 0.003213
160 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 10 43 0.0001137 0.003306
161 TUBE FORMATION 19 129 0.0001209 0.003495
162 PROTEIN TARGETING 42 406 0.0001268 0.003597
163 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 49 498 0.0001253 0.003597
164 REGULATION OF CELL MORPHOGENESIS 53 552 0.0001266 0.003597
165 NEGATIVE REGULATION OF GENE EXPRESSION 118 1493 0.0001307 0.003685
166 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 39 368 0.0001317 0.003692
167 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 28 232 0.0001341 0.003737
168 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 9 36 0.0001374 0.003804
169 REGULATION OF HOMEOSTATIC PROCESS 45 447 0.000139 0.003827
170 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 18 121 0.0001589 0.004299
171 GROWTH 42 410 0.0001572 0.004299
172 DEVELOPMENTAL GROWTH 36 333 0.0001589 0.004299
173 CELL CELL SIGNALING 68 767 0.0001698 0.004567
174 CARDIAC MUSCLE CELL ACTION POTENTIAL 9 37 0.0001725 0.004612
175 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 22 166 0.0001797 0.004752
176 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 62 684 0.0001792 0.004752
177 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 57 616 0.0001904 0.005005
178 KIDNEY MORPHOGENESIS 14 82 0.0001931 0.005012
179 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 16 102 0.0001939 0.005012
180 NEGATIVE REGULATION OF CELL COMMUNICATION 97 1192 0.0001923 0.005012
181 MESENCHYME DEVELOPMENT 24 190 0.0001974 0.005048
182 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 24 190 0.0001974 0.005048
183 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 8 30 0.0001989 0.005057
184 NEGATIVE REGULATION OF KINASE ACTIVITY 29 250 0.0002052 0.005095
185 REGULATION OF ACTIN FILAMENT BASED PROCESS 34 312 0.0002054 0.005095
186 REGULATION OF HORMONE SECRETION 30 262 0.0002022 0.005095
187 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 93 1135 0.0002059 0.005095
188 NEUROTROPHIN SIGNALING PATHWAY 7 23 0.0002031 0.005095
189 POSITIVE REGULATION OF KINASE ACTIVITY 47 482 0.0002104 0.005153
190 REGULATION OF METAL ION TRANSPORT 35 325 0.0002098 0.005153
191 REGULATION OF MUSCLE ORGAN DEVELOPMENT 16 103 0.0002177 0.005303
192 COGNITION 29 251 0.0002198 0.005326
193 NEPHRON EPITHELIUM DEVELOPMENT 15 93 0.0002223 0.005331
194 REGULATION OF ION TRANSPORT 55 592 0.0002216 0.005331
195 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 37 352 0.000228 0.00544
196 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 86 1036 0.0002339 0.005524
197 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 86 1036 0.0002339 0.005524
198 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 6 17 0.0002361 0.005549
199 CARTILAGE DEVELOPMENT 20 147 0.0002439 0.005704
200 POSITIVE REGULATION OF TRANSPORT 79 936 0.0002515 0.005852
201 EMBRYONIC ORGAN DEVELOPMENT 41 406 0.0002532 0.005861
202 EPITHELIAL TO MESENCHYMAL TRANSITION 11 56 0.0002617 0.006
203 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 11 56 0.0002617 0.006
204 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 9 39 0.0002652 0.006049
205 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 126 0.0002666 0.006051
206 REGULATION OF MEMBRANE POTENTIAL 36 343 0.0002834 0.00637
207 GLAND DEVELOPMENT 40 395 0.0002829 0.00637
208 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 17 116 0.0002872 0.006424
209 NEURAL TUBE DEVELOPMENT 20 149 0.0002927 0.006515
210 NEURAL NUCLEUS DEVELOPMENT 12 66 0.0002982 0.006606
211 REGULATION OF GLUCOSE METABOLIC PROCESS 16 106 0.0003049 0.006723
212 ACTIN FILAMENT BASED PROCESS 44 450 0.0003116 0.006839
213 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 27 232 0.0003174 0.006933
214 HEMATOPOIETIC STEM CELL DIFFERENTIATION 5 12 0.0003289 0.007152
215 POSITIVE REGULATION OF CELL PROLIFERATION 70 814 0.0003316 0.007177
216 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 147 1977 0.000334 0.007194
217 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 24 197 0.0003411 0.007314
218 REGULATION OF CALCIUM ION TRANSPORT 25 209 0.0003436 0.007334
219 EMBRYONIC PATTERN SPECIFICATION 11 58 0.0003608 0.007666
220 DIENCEPHALON DEVELOPMENT 13 77 0.0003625 0.007667
221 REGULATION OF EPITHELIAL CELL PROLIFERATION 31 285 0.0003963 0.008343
222 NEURON RECOGNITION 8 33 0.0004054 0.00846
223 VASCULATURE DEVELOPMENT 45 469 0.0004042 0.00846
224 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 27 236 0.0004169 0.008622
225 PALLIUM DEVELOPMENT 20 153 0.0004161 0.008622
226 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 15 99 0.0004462 0.009105
227 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 15 99 0.0004462 0.009105
228 LIPID PHOSPHORYLATION 15 99 0.0004462 0.009105
229 POSITIVE REGULATION OF AXONOGENESIS 12 69 0.0004566 0.009277
230 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 14 89 0.0004637 0.00938
231 NEURON MIGRATION 16 110 0.0004668 0.009403
232 MAINTENANCE OF CELL NUMBER 18 132 0.0004753 0.009532
233 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 9 42 0.0004788 0.009562
234 METENCEPHALON DEVELOPMENT 15 100 0.0004979 0.0099
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 118 1199 2.243e-09 2.083e-06
2 KINASE ACTIVITY 85 842 1.523e-07 6.475e-05
3 SEQUENCE SPECIFIC DNA BINDING 99 1037 2.091e-07 6.475e-05
4 PROTEIN KINASE ACTIVITY 67 640 9.161e-07 0.0002128
5 REGULATORY REGION NUCLEIC ACID BINDING 80 818 1.268e-06 0.0002356
6 RIBONUCLEOTIDE BINDING 152 1860 2.045e-06 0.0003166
7 ADENYL NUCLEOTIDE BINDING 127 1514 4.396e-06 0.0005834
8 INSULIN RECEPTOR BINDING 10 32 6.763e-06 0.0007854
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 89 992 1.092e-05 0.001127
10 ION CHANNEL BINDING 19 111 1.439e-05 0.001337
11 PROTEIN DOMAIN SPECIFIC BINDING 61 624 2.367e-05 0.001999
12 DOUBLE STRANDED DNA BINDING 71 764 2.808e-05 0.002174
13 MACROMOLECULAR COMPLEX BINDING 114 1399 4.933e-05 0.003525
14 KINASE BINDING 58 606 6.751e-05 0.00448
15 ENZYME BINDING 135 1737 8.966e-05 0.005553
16 CALCIUM ION BINDING 64 697 9.806e-05 0.005694
17 RECEPTOR SIGNALING PROTEIN ACTIVITY 23 172 0.0001129 0.006172
18 PROTEIN SERINE THREONINE KINASE ACTIVITY 45 445 0.0001254 0.006473
19 RNA POLYMERASE II TRANSCRIPTION COACTIVATOR ACTIVITY 9 36 0.0001374 0.006716
20 CHANNEL REGULATOR ACTIVITY 19 131 0.0001488 0.006913
21 STRUCTURAL CONSTITUENT OF RIBOSOME 26 212 0.000177 0.007832
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 110 942 2.728e-13 1.593e-10
2 NEURON PART 128 1265 7.115e-11 2.078e-08
3 CELL PROJECTION 160 1786 2.527e-09 4.92e-07
4 CYTOSOLIC RIBOSOME 24 113 1.622e-08 2.368e-06
5 SYNAPSE 81 754 2.117e-08 2.472e-06
6 CELL JUNCTION 105 1151 7.912e-07 6.6e-05
7 SOMATODENDRITIC COMPARTMENT 68 650 7.783e-07 6.6e-05
8 CYTOSOLIC LARGE RIBOSOMAL SUBUNIT 15 61 1.101e-06 8.035e-05
9 CATION CHANNEL COMPLEX 26 167 2.616e-06 0.0001698
10 DENDRITE 50 451 4.584e-06 0.0002677
11 SYNAPSE PART 62 610 6.072e-06 0.0003224
12 CYTOSOLIC PART 30 223 9.795e-06 0.0004767
13 SITE OF POLARIZED GROWTH 23 149 1.123e-05 0.0005043
14 RIBOSOMAL SUBUNIT 24 163 1.65e-05 0.0006884
15 CELL PROJECTION PART 84 946 2.817e-05 0.001097
16 POTASSIUM CHANNEL COMPLEX 16 90 4.156e-05 0.001517
17 EXCITATORY SYNAPSE 26 197 5.215e-05 0.001731
18 POSTSYNAPSE 41 378 5.334e-05 0.001731
19 AXON 44 418 5.899e-05 0.001813
20 PLASMA MEMBRANE REGION 81 929 7.288e-05 0.002128
21 LARGE RIBOSOMAL SUBUNIT 16 95 8.186e-05 0.002173
22 MEMBRANE REGION 95 1134 7.929e-05 0.002173
23 CYTOPLASMIC SIDE OF MEMBRANE 23 170 9.434e-05 0.002395
24 RIBOSOME 27 226 0.0002073 0.005044
25 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 8 31 0.0002549 0.005953
26 CELL BODY 47 494 0.0003669 0.008242
27 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 15 98 0.0003991 0.008632
28 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 27 237 0.0004457 0.009296

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Hippo_signaling_pathway_hsa04390 23 154 1.945e-05 0.001011
2 PI3K_Akt_signaling_pathway_hsa04151 39 352 5.061e-05 0.001316
3 FoxO_signaling_pathway_hsa04068 19 132 0.0001648 0.002358
4 Hedgehog_signaling_pathway_hsa04340 10 47 0.0002498 0.002358
5 TGF_beta_signaling_pathway_hsa04350 14 84 0.0002509 0.002358
6 Rap1_signaling_pathway_hsa04015 25 206 0.0002752 0.002358
7 Ras_signaling_pathway_hsa04014 27 232 0.0003174 0.002358
8 AMPK_signaling_pathway_hsa04152 17 121 0.0004758 0.003093
9 MAPK_signaling_pathway_hsa04010 31 295 0.0007116 0.003873
10 Apelin_signaling_pathway_hsa04371 18 137 0.0007448 0.003873
11 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 18 139 0.0008846 0.004182
12 Wnt_signaling_pathway_hsa04310 18 146 0.001564 0.006317
13 Tight_junction_hsa04530 20 170 0.001579 0.006317
14 Cellular_senescence_hsa04218 18 160 0.004277 0.01497
15 cAMP_signaling_pathway_hsa04024 21 198 0.004317 0.01497
16 p53_signaling_pathway_hsa04115 10 68 0.004784 0.01555
17 Adherens_junction_hsa04520 10 72 0.007201 0.02203
18 cGMP_PKG_signaling_pathway_hsa04022 17 163 0.01124 0.03248
19 Phospholipase_D_signaling_pathway_hsa04072 15 146 0.01876 0.05136
20 ErbB_signaling_pathway_hsa04012 10 85 0.0218 0.05591
21 Cell_cycle_hsa04110 13 124 0.02365 0.05591
22 Oocyte_meiosis_hsa04114 13 124 0.02365 0.05591
23 Cell_adhesion_molecules_.CAMs._hsa04514 14 145 0.03603 0.08146
24 Apoptosis_hsa04210 13 138 0.04982 0.108
25 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.07915 0.1646
26 Regulation_of_actin_cytoskeleton_hsa04810 17 208 0.08319 0.1664
27 mTOR_signaling_pathway_hsa04150 13 151 0.08768 0.1689
28 Focal_adhesion_hsa04510 16 199 0.101 0.1876
29 Autophagy_animal_hsa04140 11 128 0.1108 0.1986
30 Sphingolipid_signaling_pathway_hsa04071 10 118 0.1327 0.2299
31 Calcium_signaling_pathway_hsa04020 14 182 0.1526 0.256
32 Peroxisome_hsa04146 7 83 0.1906 0.3097
33 Gap_junction_hsa04540 7 88 0.2315 0.3649
34 VEGF_signaling_pathway_hsa04370 5 59 0.2419 0.3699
35 Apoptosis_multiple_species_hsa04215 3 33 0.2873 0.4269
36 Neuroactive_ligand_receptor_interaction_hsa04080 17 278 0.4096 0.5916
37 Jak_STAT_signaling_pathway_hsa04630 10 162 0.4378 0.6152
38 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.4937 0.6401
39 ECM_receptor_interaction_hsa04512 5 82 0.4998 0.6401
40 HIF_1_signaling_pathway_hsa04066 6 100 0.5035 0.6401
41 Mitophagy_animal_hsa04137 4 65 0.5072 0.6401
42 Notch_signaling_pathway_hsa04330 3 48 0.517 0.6401
43 Necroptosis_hsa04217 9 164 0.5885 0.7117
44 Ferroptosis_hsa04216 2 40 0.6707 0.7926
45 ABC_transporters_hsa02010 2 45 0.7324 0.8463
46 Endocytosis_hsa04144 11 244 0.8225 0.9297
47 Cytokine_cytokine_receptor_interaction_hsa04060 12 270 0.8443 0.9341
48 TNF_signaling_pathway_hsa04668 4 108 0.8677 0.94
49 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.9113 0.9671
50 Lysosome_hsa04142 3 123 0.9733 1
51 Phagosome_hsa04145 3 152 0.9929 1

Quest ID: 8d7c471eb9711541aee96daf1f261269