This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-28-5p | AAAS | -0.14 | 0.04976 | 0.33 | 0 | miRNAWalker2 validate | -0.19 | 0 | NA | |
2 | hsa-miR-28-5p | AAGAB | -0.14 | 0.04976 | 0.81 | 0 | miRanda | -0.26 | 0 | NA | |
3 | hsa-miR-28-5p | AATK | -0.14 | 0.04976 | 0.45 | 0.00408 | miRanda | -0.27 | 0.00027 | NA | |
4 | hsa-miR-28-5p | ABCB9 | -0.14 | 0.04976 | 0.95 | 0 | miRanda | -0.26 | 0 | NA | |
5 | hsa-miR-28-5p | ABCC5 | -0.14 | 0.04976 | 0.8 | 0 | miRanda | -0.16 | 0.00553 | NA | |
6 | hsa-miR-28-5p | ABHD1 | -0.14 | 0.04976 | -0.98 | 0 | miRanda | -0.3 | 7.0E-5 | NA | |
7 | hsa-miR-28-5p | ABLIM3 | -0.14 | 0.04976 | -1.88 | 0 | miRanda | -0.64 | 0 | NA | |
8 | hsa-miR-28-5p | ACACA | -0.14 | 0.04976 | -0.22 | 0.02162 | miRanda | -0.16 | 0.00043 | NA | |
9 | hsa-miR-28-5p | ACAD8 | -0.14 | 0.04976 | -0.36 | 0 | miRanda | -0.12 | 0.00017 | NA | |
10 | hsa-miR-28-5p | ACAT1 | -0.14 | 0.04976 | -0.75 | 0 | miRanda | -0.16 | 0.00027 | NA | |
11 | hsa-miR-28-5p | ACOX3 | -0.14 | 0.04976 | 0.2 | 0.02327 | miRanda | -0.18 | 1.0E-5 | NA | |
12 | hsa-miR-28-5p | ACSF2 | -0.14 | 0.04976 | -0.26 | 0.05489 | miRanda | -0.31 | 0 | NA | |
13 | hsa-miR-28-5p | ADAMTS13 | -0.14 | 0.04976 | 0.49 | 0.00058 | miRanda | -0.25 | 0.0002 | NA | |
14 | hsa-miR-28-5p | ADCK1 | -0.14 | 0.04976 | 0.19 | 0.00451 | miRanda | -0.12 | 0.00012 | NA | |
15 | hsa-miR-28-5p | ADCY1 | -0.14 | 0.04976 | -0.05 | 0.84149 | miRanda | -0.59 | 0 | NA | |
16 | hsa-miR-28-5p | ADCY6 | -0.14 | 0.04976 | -0.63 | 0 | miRanda | -0.32 | 0 | NA | |
17 | hsa-miR-28-5p | AFF1 | -0.14 | 0.04976 | -0.82 | 0 | miRanda | -0.18 | 2.0E-5 | NA | |
18 | hsa-miR-28-5p | AFF4 | -0.14 | 0.04976 | -0.28 | 0.00153 | miRanda | -0.2 | 0 | NA | |
19 | hsa-miR-28-5p | AFTPH | -0.14 | 0.04976 | 0.31 | 0 | miRanda | -0.1 | 0.00074 | NA | |
20 | hsa-miR-28-5p | AGAP11 | -0.14 | 0.04976 | -2.72 | 0 | miRanda | -0.31 | 0.00022 | NA | |
21 | hsa-miR-28-5p | AGBL4 | -0.14 | 0.04976 | -0.14 | 0.45129 | miRanda | -0.24 | 0.00912 | NA | |
22 | hsa-let-7e-5p | AGMAT | 0.26 | 0.00191 | 1.49 | 0 | miRNAWalker2 validate | -0.11 | 0.04492 | NA | |
23 | hsa-miR-28-5p | AHNAK | -0.14 | 0.04976 | -1.77 | 0 | miRanda | -0.27 | 0 | NA | |
24 | hsa-miR-28-5p | AKR7A2 | -0.14 | 0.04976 | 0.34 | 1.0E-5 | miRanda | -0.24 | 0 | NA | |
25 | hsa-miR-143-3p | AKT1 | -1.23 | 0 | 0.68 | 0 | miRNAWalker2 validate | -0.11 | 0 | NA | |
26 | hsa-miR-28-5p | ALDH3A2 | -0.14 | 0.04976 | -0.86 | 0 | miRanda | -0.29 | 0 | NA | |
27 | hsa-miR-28-5p | AMIGO2 | -0.14 | 0.04976 | -1.58 | 0 | miRanda | -0.24 | 0.00784 | NA | |
28 | hsa-miR-28-5p | AMPH | -0.14 | 0.04976 | -0.23 | 0.25767 | miRanda | -0.38 | 8.0E-5 | NA | |
29 | hsa-miR-28-5p | AMZ1 | -0.14 | 0.04976 | 2.49 | 0 | miRanda | -0.45 | 0.00014 | NA | |
30 | hsa-miR-28-5p | ANGEL1 | -0.14 | 0.04976 | -0.24 | 5.0E-5 | miRanda | -0.14 | 0 | NA | |
31 | hsa-miR-28-5p | ANKS1B | -0.14 | 0.04976 | 0.2 | 0.2194 | miRanda | -0.42 | 0 | NA | |
32 | hsa-miR-28-5p | ANKS3 | -0.14 | 0.04976 | 0.72 | 0 | miRanda | -0.16 | 0.0011 | NA | |
33 | hsa-miR-28-5p | ANXA9 | -0.14 | 0.04976 | 1.78 | 0 | miRanda | -1.05 | 0 | NA | |
34 | hsa-miR-28-5p | AP2A2 | -0.14 | 0.04976 | 0.03 | 0.55943 | miRanda | -0.12 | 0 | NA | |
35 | hsa-miR-28-5p | AP2B1 | -0.14 | 0.04976 | 0.26 | 0.00183 | miRanda | -0.22 | 0 | NA | |
36 | hsa-miR-145-5p | APH1A | -2.63 | 0 | 0.88 | 0 | miRNAWalker2 validate | -0.18 | 0 | NA | |
37 | hsa-miR-28-5p | ARAF | -0.14 | 0.04976 | 0.24 | 1.0E-5 | miRanda | -0.11 | 4.0E-5 | NA | |
38 | hsa-miR-132-3p | ARHGAP32 | -0.04 | 0.6686 | 0.43 | 9.0E-5 | miRNAWalker2 validate; miRTarBase | -0.22 | 0 | NA | |
39 | hsa-miR-28-5p | ARHGAP32 | -0.14 | 0.04976 | 0.43 | 9.0E-5 | miRanda | -0.36 | 0 | NA | |
40 | hsa-miR-28-5p | ARHGAP8 | -0.14 | 0.04976 | 1.29 | 0 | miRanda | -0.12 | 0.04559 | NA | |
41 | hsa-miR-28-5p | ARHGEF16 | -0.14 | 0.04976 | 1.35 | 0 | miRanda | -0.31 | 0 | NA | |
42 | hsa-miR-28-5p | ARL17A | -0.14 | 0.04976 | -0.08 | 0.37677 | miRanda | -0.12 | 0.00459 | NA | |
43 | hsa-miR-28-5p | ARL6IP4 | -0.14 | 0.04976 | 0.5 | 0 | miRanda | -0.19 | 0.00019 | NA | |
44 | hsa-miR-28-5p | ARMC5 | -0.14 | 0.04976 | 0.67 | 0 | miRanda | -0.28 | 0 | NA | |
45 | hsa-miR-28-5p | ARMC7 | -0.14 | 0.04976 | 0.79 | 0 | miRanda | -0.13 | 0.00026 | NA | |
46 | hsa-miR-28-5p | ARMC9 | -0.14 | 0.04976 | 1.05 | 0 | miRanda | -0.18 | 0 | NA | |
47 | hsa-miR-28-5p | ASB8 | -0.14 | 0.04976 | -0.21 | 0.00012 | miRanda | -0.19 | 0 | NA | |
48 | hsa-miR-132-3p | ATP6V0E1 | -0.04 | 0.6686 | 0.38 | 0 | miRNAWalker2 validate | -0.1 | 6.0E-5 | NA | |
49 | hsa-miR-28-5p | ATPAF1 | -0.14 | 0.04976 | -0.16 | 0.00532 | miRanda | -0.12 | 1.0E-5 | NA | |
50 | hsa-miR-28-5p | ATRNL1 | -0.14 | 0.04976 | -0.74 | 0.02081 | miRanda | -0.53 | 0.00049 | NA | |
51 | hsa-miR-28-5p | B3GALT4 | -0.14 | 0.04976 | 0.46 | 1.0E-5 | miRanda | -0.14 | 0.00301 | NA | |
52 | hsa-miR-28-5p | BAG1 | -0.14 | 0.04976 | 0.42 | 2.0E-5 | miRanda | -0.31 | 0 | NA | |
53 | hsa-miR-28-5p | BBS1 | -0.14 | 0.04976 | -0.09 | 0.27359 | miRanda | -0.29 | 0 | NA | |
54 | hsa-miR-28-5p | BCAM | -0.14 | 0.04976 | 0.51 | 0.00081 | miRanda | -0.64 | 0 | NA | |
55 | hsa-miR-28-5p | BHLHE40 | -0.14 | 0.04976 | 0.41 | 0.00047 | miRanda | -0.47 | 0 | NA | |
56 | hsa-let-7e-5p | BMP2K | 0.26 | 0.00191 | -0.61 | 0 | miRNAWalker2 validate | -0.11 | 0.01434 | NA | |
57 | hsa-miR-28-5p | BTRC | -0.14 | 0.04976 | 0.12 | 0.15929 | miRanda | -0.25 | 0 | NA | |
58 | hsa-miR-28-5p | CACNG4 | -0.14 | 0.04976 | 2.21 | 0 | miRanda | -0.63 | 2.0E-5 | NA | |
59 | hsa-miR-28-5p | CALCOCO1 | -0.14 | 0.04976 | -1.08 | 0 | miRanda | -0.14 | 8.0E-5 | NA | |
60 | hsa-miR-28-5p | CALCOCO2 | -0.14 | 0.04976 | -0.44 | 0 | miRanda | -0.2 | 0 | NA | |
61 | hsa-miR-28-5p | CANT1 | -0.14 | 0.04976 | 1.19 | 0 | miRanda | -0.31 | 0 | NA | |
62 | hsa-miR-28-5p | CASC2 | -0.14 | 0.04976 | -0.06 | 0.56145 | miRanda | -0.21 | 1.0E-5 | NA | |
63 | hsa-miR-132-3p | CASP7 | -0.04 | 0.6686 | 0.1 | 0.18258 | miRNAWalker2 validate | -0.11 | 0.00022 | NA | |
64 | hsa-miR-28-5p | CCDC113 | -0.14 | 0.04976 | 0.15 | 0.13693 | miRanda | -0.15 | 0.0019 | NA | |
65 | hsa-miR-28-5p | CCDC114 | -0.14 | 0.04976 | 1.17 | 0 | miRanda | -0.3 | 0.00046 | NA | |
66 | hsa-miR-28-5p | CCDC85A | -0.14 | 0.04976 | -2.64 | 0 | miRanda | -0.2 | 0.02171 | NA | |
67 | hsa-miR-28-5p | CCDC87 | -0.14 | 0.04976 | 1.38 | 0 | miRanda | -0.5 | 0 | NA | |
68 | hsa-miR-28-5p | CCNDBP1 | -0.14 | 0.04976 | -0.73 | 0 | miRanda | -0.17 | 0 | NA | |
69 | hsa-miR-28-5p | CCNG2 | -0.14 | 0.04976 | -0.15 | 0.14084 | miRanda | -0.2 | 3.0E-5 | NA | |
70 | hsa-miR-132-3p | CD164 | -0.04 | 0.6686 | -0.29 | 0.00028 | miRNAWalker2 validate | -0.19 | 0 | NA | |
71 | hsa-miR-28-5p | CD2BP2 | -0.14 | 0.04976 | 0.73 | 0 | miRanda | -0.24 | 0 | NA | |
72 | hsa-miR-132-3p | CD55 | -0.04 | 0.6686 | -0.36 | 0.00102 | miRNAWalker2 validate | -0.12 | 0.00697 | NA | |
73 | hsa-miR-28-5p | CDH18 | -0.14 | 0.04976 | -0.05 | 0.84157 | miRanda | -0.34 | 0.00651 | NA | |
74 | hsa-miR-28-5p | CDH7 | -0.14 | 0.04976 | 1.31 | 2.0E-5 | miRanda | -0.56 | 0.00015 | NA | |
75 | hsa-miR-28-5p | CDK17 | -0.14 | 0.04976 | -0.12 | 0.11999 | miRanda | -0.27 | 0 | NA | |
76 | hsa-miR-145-5p | CDK4 | -2.63 | 0 | 0.6 | 0 | miRNAWalker2 validate; miRTarBase | -0.13 | 0 | 21092188 | Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control |
77 | hsa-miR-28-5p | CDK5 | -0.14 | 0.04976 | 1.49 | 0 | miRanda | -0.23 | 0 | NA | |
78 | hsa-miR-28-5p | CDKN1A | -0.14 | 0.04976 | -0.25 | 0.02507 | miRNAWalker2 validate; miRTarBase; miRanda | -0.29 | 0 | NA | |
79 | hsa-miR-28-5p | CDON | -0.14 | 0.04976 | -0.99 | 0 | miRanda | -0.22 | 0.00112 | NA | |
80 | hsa-miR-28-5p | CEACAM6 | -0.14 | 0.04976 | 3.15 | 0 | miRanda | -1.28 | 0 | NA | |
81 | hsa-miR-28-5p | CEACAM7 | -0.14 | 0.04976 | 1.14 | 7.0E-5 | miRanda | -1.1 | 0 | NA | |
82 | hsa-let-7e-5p | CELF2 | 0.26 | 0.00191 | -2.12 | 0 | miRNAWalker2 validate | -0.21 | 0.00025 | NA | |
83 | hsa-miR-28-5p | CHAD | -0.14 | 0.04976 | -0 | 0.99305 | miRanda | -0.9 | 0 | NA | |
84 | hsa-miR-28-5p | CHD3 | -0.14 | 0.04976 | 0.23 | 0.00044 | miRanda | -0.15 | 0 | NA | |
85 | hsa-miR-28-5p | CHDH | -0.14 | 0.04976 | 0.09 | 0.50882 | miRanda | -0.3 | 1.0E-5 | NA | |
86 | hsa-miR-28-5p | CLASP2 | -0.14 | 0.04976 | -0.48 | 0 | miRanda | -0.16 | 0 | NA | |
87 | hsa-miR-28-5p | CNKSR1 | -0.14 | 0.04976 | 1.45 | 0 | miRanda | -0.14 | 0.03787 | NA | |
88 | hsa-miR-28-5p | COL3A1 | -0.14 | 0.04976 | 1.5 | 0 | miRanda | -0.22 | 0.00939 | NA | |
89 | hsa-miR-28-5p | COL6A3 | -0.14 | 0.04976 | 0.63 | 2.0E-5 | miRanda | -0.14 | 0.04652 | NA | |
90 | hsa-miR-28-5p | COMMD3 | -0.14 | 0.04976 | 0.68 | 0 | miRanda | -0.13 | 0.00027 | NA | |
91 | hsa-miR-28-5p | COPG2 | -0.14 | 0.04976 | 0.25 | 0.00034 | miRanda | -0.18 | 0 | NA | |
92 | hsa-miR-28-5p | CPD | -0.14 | 0.04976 | -0.24 | 0.02078 | miRanda | -0.26 | 0 | NA | |
93 | hsa-miR-28-5p | CRADD | -0.14 | 0.04976 | -0.25 | 0.00023 | miRanda | -0.24 | 0 | NA | |
94 | hsa-miR-28-5p | CREBL2 | -0.14 | 0.04976 | -0.83 | 0 | miRanda | -0.12 | 0.00037 | NA | |
95 | hsa-miR-28-5p | CROT | -0.14 | 0.04976 | 0.04 | 0.77707 | miRanda | -0.44 | 0 | NA | |
96 | hsa-miR-28-5p | CRY2 | -0.14 | 0.04976 | -1.2 | 0 | miRanda | -0.22 | 0 | NA | |
97 | hsa-miR-132-3p | CST9L | -0.04 | 0.6686 | 0.9 | 0.00141 | miRNAWalker2 validate | -0.26 | 0.0255 | NA | |
98 | hsa-miR-28-5p | CYTH2 | -0.14 | 0.04976 | 0.7 | 0 | miRanda | -0.2 | 0 | NA | |
99 | hsa-miR-28-5p | DALRD3 | -0.14 | 0.04976 | 0.59 | 0 | miRanda | -0.45 | 0 | NA | |
100 | hsa-miR-28-5p | DAZAP2 | -0.14 | 0.04976 | 0.05 | 0.32954 | miRanda | -0.17 | 0 | NA | |
101 | hsa-miR-28-5p | DDX60 | -0.14 | 0.04976 | 0.26 | 0.04951 | miRanda | -0.12 | 0.04794 | NA | |
102 | hsa-miR-28-5p | DHRS2 | -0.14 | 0.04976 | 1.08 | 0.01801 | miRanda | -1.42 | 0 | NA | |
103 | hsa-miR-28-5p | DHRS4 | -0.14 | 0.04976 | 0.08 | 0.36032 | miRanda | -0.25 | 0 | NA | |
104 | hsa-miR-28-5p | DHRS4L1 | -0.14 | 0.04976 | -0.1 | 0.44303 | miRanda | -0.35 | 0 | NA | |
105 | hsa-miR-28-5p | DHRS4L2 | -0.14 | 0.04976 | -0.01 | 0.88566 | miRanda | -0.24 | 0 | NA | |
106 | hsa-miR-28-5p | DHRS7B | -0.14 | 0.04976 | -0.23 | 0.00249 | miRanda | -0.2 | 0 | NA | |
107 | hsa-miR-28-5p | DHX29 | -0.14 | 0.04976 | 0.07 | 0.25412 | miRanda | -0.23 | 0 | NA | |
108 | hsa-miR-28-5p | DHX58 | -0.14 | 0.04976 | 0.57 | 0 | miRanda | -0.2 | 3.0E-5 | NA | |
109 | hsa-miR-28-5p | DNAJA4 | -0.14 | 0.04976 | 0.78 | 0 | miRanda | -0.37 | 0 | NA | |
110 | hsa-miR-28-5p | DNAJB14 | -0.14 | 0.04976 | -0.39 | 1.0E-5 | miRanda | -0.13 | 0.00215 | NA | |
111 | hsa-miR-28-5p | DNAJC12 | -0.14 | 0.04976 | 1.44 | 0 | miRanda | -1.08 | 0 | NA | |
112 | hsa-miR-28-5p | DNMBP | -0.14 | 0.04976 | -0.67 | 0 | miRanda | -0.28 | 0 | NA | |
113 | hsa-miR-143-3p | DNMT3A | -1.23 | 0 | 0.95 | 0 | miRNAWalker2 validate; miRTarBase | -0.13 | 0 | 24218337; 19638978 | Ectopic expression of miR-143 inhibited proliferation and soft agar colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A DNMT3A expression on both mRNA and protein levels; DNMT3A was demonstrated to be a direct target of miR-143 by luciferase reporter assay; Furthermore miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in breast cancer tissues; Our findings suggest that miR-143 regulates DNMT3A in breast cancer cells;Using in silico predictions DNA methyltranferase 3A DNMT3A was defined as a potential target of miR-143; Restoration of the miR-143 expression in colon cell lines decreased tumour cell growth and soft-agar colony formation and downregulated the DNMT3A expression in both mRNA and protein levels; DNMT3A was shown to be a direct target of miR-143 by luciferase reporter assay; Furthermore the miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in CRC tissues; Our findings suggest that miR-143 regulates DNMT3A in CRC |
114 | hsa-miR-28-5p | DPH1 | -0.14 | 0.04976 | -0.03 | 0.66337 | miRanda | -0.14 | 1.0E-5 | NA | |
115 | hsa-miR-28-5p | DPP3 | -0.14 | 0.04976 | 1.58 | 0 | miRanda | -0.19 | 3.0E-5 | NA | |
116 | hsa-miR-28-5p | DQX1 | -0.14 | 0.04976 | 3.64 | 0 | miRanda | -0.79 | 0 | NA | |
117 | hsa-miR-28-5p | DTWD2 | -0.14 | 0.04976 | -0.26 | 0.00652 | miRanda | -0.32 | 0 | NA | |
118 | hsa-miR-28-5p | DYNC2LI1 | -0.14 | 0.04976 | -0 | 0.96365 | miRanda | -0.13 | 0 | NA | |
119 | hsa-miR-28-5p | DYNLL2 | -0.14 | 0.04976 | 0.06 | 0.38599 | miRanda | -0.14 | 8.0E-5 | NA | |
120 | hsa-miR-28-5p | DYNLRB2 | -0.14 | 0.04976 | 0.03 | 0.90674 | miRanda | -0.96 | 0 | NA | |
121 | hsa-miR-205-5p | E2F1 | -1.7 | 0 | 2.6 | 0 | miRNAWalker2 validate; miRTarBase | -0.15 | 0 | 22578566; 21454583 | Re-expression of miR-205 where absent strongly reduces cell proliferation cell cycle progression and clonogenic potential in vitro and inhibits tumor growth in vivo and this tumor suppressor activity is at least partially exerted through targeting of E2F1 master regulator of cell cycle progression and LAMC1 component of extracellular matrix involved in cell adhesion proliferation and migration;The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels |
122 | hsa-miR-28-5p | EDA2R | -0.14 | 0.04976 | -1.34 | 0 | miRanda | -0.23 | 0.00086 | NA | |
123 | hsa-miR-200c-3p | EDNRA | 2.07 | 0 | -0.14 | 0.24185 | miRNAWalker2 validate | -0.24 | 0 | NA | |
124 | hsa-miR-28-5p | EGLN3 | -0.14 | 0.04976 | 1.25 | 0 | miRanda | -0.21 | 0.00907 | NA | |
125 | hsa-miR-28-5p | EIF2AK1 | -0.14 | 0.04976 | 0.86 | 0 | miRanda | -0.14 | 0 | NA | |
126 | hsa-miR-28-5p | EIF4E3 | -0.14 | 0.04976 | -1.14 | 0 | miRanda | -0.2 | 1.0E-5 | NA | |
127 | hsa-miR-28-5p | ELMOD3 | -0.14 | 0.04976 | -1.18 | 0 | miRanda | -0.13 | 0.00085 | NA | |
128 | hsa-miR-28-5p | ENOSF1 | -0.14 | 0.04976 | -0.05 | 0.53098 | miRanda | -0.12 | 0.00186 | NA | |
129 | hsa-miR-28-5p | ENPP5 | -0.14 | 0.04976 | 0.73 | 0.00025 | miRanda | -0.43 | 1.0E-5 | NA | |
130 | hsa-miR-28-5p | EPB41L4A | -0.14 | 0.04976 | -0.67 | 0 | miRanda | -0.39 | 0 | NA | |
131 | hsa-miR-28-5p | EPM2AIP1 | -0.14 | 0.04976 | -0.44 | 0 | miRanda | -0.14 | 0.00015 | NA | |
132 | hsa-miR-28-5p | EPN1 | -0.14 | 0.04976 | 0.76 | 0 | miRanda | -0.12 | 0.0021 | NA | |
133 | hsa-miR-28-5p | EPN2 | -0.14 | 0.04976 | -0.03 | 0.69538 | miRanda | -0.16 | 0 | NA | |
134 | hsa-miR-28-5p | ERAL1 | -0.14 | 0.04976 | 0.6 | 0 | miRanda | -0.13 | 0.00024 | NA | |
135 | hsa-miR-28-5p | ERGIC1 | -0.14 | 0.04976 | 0.65 | 0 | miRanda | -0.42 | 0 | NA | |
136 | hsa-miR-28-5p | ERI2 | -0.14 | 0.04976 | 0.37 | 1.0E-5 | miRanda | -0.27 | 0 | NA | |
137 | hsa-miR-28-5p | ERLIN2 | -0.14 | 0.04976 | 0 | 0.96954 | miRanda | -0.25 | 0 | NA | |
138 | hsa-miR-200c-3p | ERRFI1 | 2.07 | 0 | -1.06 | 0 | miRNAWalker2 validate; miRTarBase | -0.14 | 0 | NA | |
139 | hsa-miR-200b-3p | ETS1 | 2.12 | 0 | -0.98 | 0 | miRNAWalker2 validate; miRTarBase | -0.25 | 0 | NA | |
140 | hsa-miR-28-5p | EXOC6 | -0.14 | 0.04976 | 0.31 | 0.00088 | miRanda | -0.33 | 0 | NA | |
141 | hsa-miR-132-3p | EYA4 | -0.04 | 0.6686 | -1.71 | 0 | miRNAWalker2 validate | -0.24 | 0.02768 | NA | |
142 | hsa-miR-145-5p | F11R | -2.63 | 0 | 0.78 | 0 | miRNAWalker2 validate | -0.12 | 0 | 20818426; 26374689 | Our data identify JAM-A and fascin as novel targets of miR-145 firmly establishing a role for miR-145 in modulating breast cancer cell motility;MicroRNA screening predicted that microRNA-145 miR-145 would bind to JAM-A; Using patient-derived glioblastoma CSCs we confirmed that JAM-A is suppressed by miR-145 |
143 | hsa-miR-28-5p | F2RL2 | -0.14 | 0.04976 | 1.83 | 0 | miRanda | -0.46 | 7.0E-5 | NA | |
144 | hsa-miR-28-5p | FAHD1 | -0.14 | 0.04976 | 0.78 | 0 | miRanda | -0.25 | 0 | NA | |
145 | hsa-miR-28-5p | FAM110B | -0.14 | 0.04976 | 0.45 | 0.0022 | miRanda | -0.44 | 0 | NA | |
146 | hsa-miR-28-5p | FAM134C | -0.14 | 0.04976 | 0.22 | 0.00023 | miRanda | -0.18 | 0 | NA | |
147 | hsa-miR-28-5p | FAM135B | -0.14 | 0.04976 | 0.3 | 0.29265 | miRanda | -0.64 | 0 | NA | |
148 | hsa-miR-28-5p | FAM151B | -0.14 | 0.04976 | 0.35 | 0.00022 | miRanda | -0.36 | 0 | NA | |
149 | hsa-miR-28-5p | FAM160A2 | -0.14 | 0.04976 | -0.15 | 0.0058 | miRanda | -0.12 | 0 | NA | |
150 | hsa-miR-28-5p | FAM169A | -0.14 | 0.04976 | 0 | 0.99613 | miRanda | -0.17 | 0.0158 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION | 24 | 278 | 2.687e-07 | 0.00125 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | GOLGI APPARATUS PART | 49 | 893 | 5.735e-07 | 0.0001675 |
2 | GOLGI APPARATUS | 69 | 1445 | 4.976e-07 | 0.0001675 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | FoxO_signaling_pathway_hsa04068 | 15 | 132 | 1.646e-06 | 8.557e-05 | |
2 | Cellular_senescence_hsa04218 | 15 | 160 | 1.769e-05 | 0.0004599 | |
3 | MAPK_signaling_pathway_hsa04010 | 19 | 295 | 0.000256 | 0.004438 | |
4 | Focal_adhesion_hsa04510 | 14 | 199 | 0.000686 | 0.008919 | |
5 | PI3K_Akt_signaling_pathway_hsa04151 | 20 | 352 | 0.0008807 | 0.009159 | |
6 | Ras_signaling_pathway_hsa04014 | 15 | 232 | 0.001067 | 0.009248 | |
7 | Phospholipase_D_signaling_pathway_hsa04072 | 11 | 146 | 0.00145 | 0.00927 | |
8 | ErbB_signaling_pathway_hsa04012 | 8 | 85 | 0.001572 | 0.00927 | |
9 | p53_signaling_pathway_hsa04115 | 7 | 68 | 0.00182 | 0.00927 | |
10 | TNF_signaling_pathway_hsa04668 | 9 | 108 | 0.001929 | 0.00927 | |
11 | cAMP_signaling_pathway_hsa04024 | 13 | 198 | 0.001961 | 0.00927 | |
12 | Rap1_signaling_pathway_hsa04015 | 13 | 206 | 0.002772 | 0.01201 | |
13 | VEGF_signaling_pathway_hsa04370 | 6 | 59 | 0.004059 | 0.01624 | |
14 | Mitophagy_animal_hsa04137 | 6 | 65 | 0.00654 | 0.02429 | |
15 | Regulation_of_actin_cytoskeleton_hsa04810 | 12 | 208 | 0.007981 | 0.02767 | |
16 | Endocytosis_hsa04144 | 13 | 244 | 0.01111 | 0.03609 | |
17 | AMPK_signaling_pathway_hsa04152 | 8 | 121 | 0.01322 | 0.04045 | |
18 | Phosphatidylinositol_signaling_system_hsa04070 | 7 | 99 | 0.01419 | 0.04086 | |
19 | HIF_1_signaling_pathway_hsa04066 | 7 | 100 | 0.01493 | 0.04086 | |
20 | Peroxisome_hsa04146 | 6 | 83 | 0.02035 | 0.0529 | |
21 | Jak_STAT_signaling_pathway_hsa04630 | 9 | 162 | 0.02494 | 0.06071 | |
22 | Gap_junction_hsa04540 | 6 | 88 | 0.02628 | 0.06071 | |
23 | Apoptosis_hsa04210 | 8 | 138 | 0.02685 | 0.06071 | |
24 | Sphingolipid_signaling_pathway_hsa04071 | 7 | 118 | 0.03333 | 0.07222 | |
25 | mTOR_signaling_pathway_hsa04150 | 8 | 151 | 0.04232 | 0.08803 | |
26 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 7 | 139 | 0.06887 | 0.1377 | |
27 | Autophagy_animal_hsa04140 | 6 | 128 | 0.1141 | 0.2197 | |
28 | Hedgehog_signaling_pathway_hsa04340 | 3 | 47 | 0.1208 | 0.2243 | |
29 | Notch_signaling_pathway_hsa04330 | 3 | 48 | 0.1265 | 0.2268 | |
30 | Apelin_signaling_pathway_hsa04371 | 6 | 137 | 0.1437 | 0.2491 | |
31 | Hippo_signaling_pathway_multiple_species_hsa04392 | 2 | 29 | 0.1714 | 0.2876 | |
32 | Calcium_signaling_pathway_hsa04020 | 7 | 182 | 0.1916 | 0.3114 | |
33 | Cell_cycle_hsa04110 | 5 | 124 | 0.2169 | 0.3418 | |
34 | Tight_junction_hsa04530 | 6 | 170 | 0.2759 | 0.422 | |
35 | Adherens_junction_hsa04520 | 3 | 72 | 0.2842 | 0.4223 | |
36 | ABC_transporters_hsa02010 | 2 | 45 | 0.324 | 0.4681 | |
37 | ECM_receptor_interaction_hsa04512 | 3 | 82 | 0.355 | 0.499 | |
38 | Hippo_signaling_pathway_hsa04390 | 5 | 154 | 0.3658 | 0.5006 | |
39 | Lysosome_hsa04142 | 4 | 123 | 0.3922 | 0.5229 | |
40 | Cell_adhesion_molecules_.CAMs._hsa04514 | 4 | 145 | 0.5169 | 0.672 | |
41 | Cytokine_cytokine_receptor_interaction_hsa04060 | 7 | 270 | 0.5481 | 0.6951 | |
42 | Neuroactive_ligand_receptor_interaction_hsa04080 | 7 | 278 | 0.5791 | 0.7003 | |
43 | cGMP_PKG_signaling_pathway_hsa04022 | 4 | 163 | 0.6094 | 0.7202 | |
44 | Oocyte_meiosis_hsa04114 | 3 | 124 | 0.624 | 0.721 | |
45 | NF_kappa_B_signaling_pathway_hsa04064 | 2 | 95 | 0.7072 | 0.7995 | |
46 | Wnt_signaling_pathway_hsa04310 | 3 | 146 | 0.7305 | 0.8083 | |
47 | Necroptosis_hsa04217 | 3 | 164 | 0.7988 | 0.8654 |