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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7b-5p AIFM1 0.06 0.7814 -0.33 0.06746 miRNATAP -0.19 0.00202 NA
2 hsa-let-7i-5p AIFM1 0.8 3.0E-5 -0.33 0.06746 miRNATAP -0.23 0.00049 NA
3 hsa-miR-125b-5p AIFM1 -0.51 0.13327 -0.33 0.06746 miRNATAP -0.22 0 NA
4 hsa-miR-199a-5p AIFM1 0.37 0.23266 -0.33 0.06746 miRanda -0.21 0 NA
5 hsa-miR-21-5p AKT2 1.75 0 -0.01 0.9227 miRNAWalker2 validate -0.15 0.00352 NA
6 hsa-miR-29b-3p AKT2 -0.23 0.36746 -0.01 0.9227 MirTarget -0.14 0.00022 26512921; 26564501; 24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
7 hsa-miR-106b-5p AKT3 1.71 0 -0.75 0.06936 miRNATAP -0.37 7.0E-5 NA
8 hsa-miR-107 AKT3 0.9 5.0E-5 -0.75 0.06936 PITA; miRanda -0.6 0 NA
9 hsa-miR-15b-5p AKT3 1.62 0 -0.75 0.06936 miRNATAP -0.36 0.00041 NA
10 hsa-miR-16-5p AKT3 1.01 1.0E-5 -0.75 0.06936 miRNAWalker2 validate; miRTarBase; miRNATAP -0.47 0.00031 NA
11 hsa-miR-17-3p AKT3 1.31 0 -0.75 0.06936 miRNATAP -0.52 0 NA
12 hsa-miR-17-5p AKT3 1.66 0 -0.75 0.06936 TargetScan; miRNATAP -0.28 0.0027 NA
13 hsa-miR-29a-3p AKT3 -0.11 0.61501 -0.75 0.06936 miRNATAP -0.41 0.00212 NA
14 hsa-miR-29b-3p AKT3 -0.23 0.36746 -0.75 0.06936 miRNATAP -0.34 0.00361 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
15 hsa-miR-32-3p AKT3 0.58 0.11837 -0.75 0.06936 mirMAP -0.32 0.00023 NA
16 hsa-miR-320b AKT3 1.11 0.0005 -0.75 0.06936 PITA; miRanda; miRNATAP -0.26 0.0039 NA
17 hsa-miR-335-3p AKT3 2.52 0 -0.75 0.06936 mirMAP -0.22 0.00074 NA
18 hsa-miR-33a-3p AKT3 0.35 0.32171 -0.75 0.06936 mirMAP -0.38 2.0E-5 NA
19 hsa-miR-362-3p AKT3 -0.03 0.91378 -0.75 0.06936 miRanda -0.38 4.0E-5 NA
20 hsa-miR-362-5p AKT3 -0.35 0.35491 -0.75 0.06936 PITA; TargetScan; miRNATAP -0.23 0.00253 NA
21 hsa-miR-501-3p AKT3 0.73 0.02704 -0.75 0.06936 miRNATAP -0.39 1.0E-5 NA
22 hsa-miR-502-3p AKT3 -0.16 0.55747 -0.75 0.06936 miRNATAP -0.5 0 NA
23 hsa-miR-505-3p AKT3 0.83 0.00112 -0.75 0.06936 mirMAP -0.35 0.00235 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
24 hsa-miR-548v AKT3 -0.16 0.70867 -0.75 0.06936 miRNATAP -0.27 0.00031 NA
25 hsa-miR-577 AKT3 0.91 0.22561 -0.75 0.06936 mirMAP -0.23 0 NA
26 hsa-miR-616-5p AKT3 0.83 0.03478 -0.75 0.06936 mirMAP -0.27 0.00041 NA
27 hsa-miR-23a-3p APAF1 1.11 0 0.3 0.22769 miRNATAP -0.49 0 24992592; 24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed
28 hsa-miR-23b-3p APAF1 -0.29 0.18665 0.3 0.22769 miRNATAP -0.54 0 NA
29 hsa-miR-27a-3p APAF1 1.3 0 0.3 0.22769 miRNATAP -0.39 0 NA
30 hsa-miR-27b-3p APAF1 0.08 0.72527 0.3 0.22769 miRNATAP -0.48 0 NA
31 hsa-miR-708-3p APAF1 0.62 0.27536 0.3 0.22769 mirMAP -0.24 0 NA
32 hsa-miR-944 APAF1 3.33 0.01778 0.3 0.22769 miRNATAP -0.13 0 NA
33 hsa-miR-125a-3p ATM 1.2 0.00164 -0.39 0.08341 miRanda -0.13 0.00188 NA
34 hsa-miR-203a-3p ATM 1.45 0.03941 -0.39 0.08341 MirTarget -0.14 0 24145123; 27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression
35 hsa-miR-590-5p ATM 1.04 0.00027 -0.39 0.08341 mirMAP -0.17 0.00247 NA
36 hsa-miR-30a-5p BAX -1.72 0 1.23 0 miRNAWalker2 validate -0.15 0.00018 NA
37 hsa-miR-365a-3p BAX -0.89 0.00255 1.23 0 miRNAWalker2 validate -0.19 6.0E-5 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX
38 hsa-miR-15b-3p BCL2 1.76 0 -1.09 0.00317 mirMAP -0.24 0.00334 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
39 hsa-miR-16-2-3p BCL2 1.8 0 -1.09 0.00317 mirMAP -0.26 0.0023 NA
40 hsa-miR-200a-5p BCL2 1.5 0.00264 -1.09 0.00317 mirMAP -0.21 5.0E-5 NA
41 hsa-miR-200b-3p BCL2 0.97 0.0595 -1.09 0.00317 miRNAWalker2 validate; miRTarBase; TargetScan; mirMAP -0.18 0.00034 NA
42 hsa-miR-200b-5p BCL2 0.97 0.05305 -1.09 0.00317 mirMAP -0.21 0.00019 NA
43 hsa-miR-200c-3p BCL2 1.28 0.0037 -1.09 0.00317 miRNAWalker2 validate; miRTarBase; mirMAP -0.23 0.00013 NA
44 hsa-miR-20a-3p BCL2 1.14 0.00045 -1.09 0.00317 mirMAP -0.22 0.00669 NA
45 hsa-miR-21-5p BCL2 1.75 0 -1.09 0.00317 miRNAWalker2 validate; miRTarBase -0.57 2.0E-5 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
46 hsa-miR-29a-5p BCL2 0.59 0.02301 -1.09 0.00317 mirMAP -0.28 0.00622 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
47 hsa-miR-335-3p BCL2 2.52 0 -1.09 0.00317 mirMAP -0.17 0.00598 NA
48 hsa-miR-429 BCL2 1.4 0.009 -1.09 0.00317 miRNAWalker2 validate; miRTarBase; PITA; mirMAP -0.2 3.0E-5 23999873; 26513239; 26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation
49 hsa-miR-455-5p BCL2 1.2 7.0E-5 -1.09 0.00317 mirMAP -0.35 4.0E-5 NA
50 hsa-miR-577 BCL2 0.91 0.22561 -1.09 0.00317 PITA -0.1 0.00537 NA
51 hsa-miR-7-5p BCL2 1.64 0.01244 -1.09 0.00317 miRNAWalker2 validate; miRTarBase; mirMAP -0.14 0.00068 26464649; 25862909; 21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions
52 hsa-let-7b-5p BCL2L1 0.06 0.7814 0.21 0.39578 miRNATAP -0.31 0.00027 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
53 hsa-let-7c-5p BCL2L1 -0.5 0.20685 0.21 0.39578 miRNAWalker2 validate; miRTarBase -0.2 1.0E-5 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA
54 hsa-miR-149-5p BCL2L1 0.71 0.29685 0.21 0.39578 mirMAP -0.17 0 NA
55 hsa-miR-214-3p BCL2L1 1.01 0.00625 0.21 0.39578 mirMAP -0.13 0.00824 NA
56 hsa-miR-23b-3p BCL2L1 -0.29 0.18665 0.21 0.39578 miRNAWalker2 validate -0.39 0 NA
57 hsa-miR-491-5p CAPN1 -0.69 0.03136 0.47 0.04786 miRanda -0.18 0.0005 NA
58 hsa-miR-107 CAPN2 0.9 5.0E-5 -0.59 0.00617 miRanda -0.2 0.00395 NA
59 hsa-miR-320a CAPN2 0.59 0.0119 -0.59 0.00617 miRanda -0.26 6.0E-5 NA
60 hsa-miR-320b CAPN2 1.11 0.0005 -0.59 0.00617 miRanda -0.16 0.00048 NA
61 hsa-miR-421 CAPN2 1.81 0 -0.59 0.00617 miRanda -0.18 2.0E-5 NA
62 hsa-miR-125b-5p CASP10 -0.51 0.13327 0.32 0.44988 mirMAP -0.45 0 NA
63 hsa-miR-129-5p CASP10 -2.57 0 0.32 0.44988 mirMAP -0.15 0.0057 NA
64 hsa-miR-145-3p CASP10 -1.65 2.0E-5 0.32 0.44988 mirMAP -0.22 0.00525 NA
65 hsa-miR-145-5p CASP10 -1.75 2.0E-5 0.32 0.44988 mirMAP -0.21 0.00404 NA
66 hsa-miR-34c-3p CASP10 2.25 9.0E-5 0.32 0.44988 mirMAP -0.32 0 NA
67 hsa-miR-452-5p CASP10 2.09 0.00026 0.32 0.44988 mirMAP -0.28 0 NA
68 hsa-miR-744-3p CASP10 1.4 0.00097 0.32 0.44988 mirMAP -0.35 0 NA
69 hsa-miR-23b-3p CASP7 -0.29 0.18665 0.22 0.30127 MirTarget -0.19 0.00671 NA
70 hsa-miR-9-3p CASP7 0.33 0.54111 0.22 0.30127 MirTarget -0.1 0.00051 NA
71 hsa-miR-129-5p CASP8 -2.57 0 1.08 0 miRanda -0.14 0 NA
72 hsa-miR-143-3p CASP8 -0.66 0.04832 1.08 0 MirTarget -0.19 3.0E-5 NA
73 hsa-miR-193b-3p CASP9 0.28 0.45126 -0.31 0.11004 miRNAWalker2 validate -0.17 0 NA
74 hsa-miR-130a-3p CFLAR 0.15 0.63374 0.07 0.73819 mirMAP -0.14 0.00421 NA
75 hsa-miR-130b-3p CFLAR 1.33 5.0E-5 0.07 0.73819 mirMAP -0.21 0 NA
76 hsa-miR-15b-5p CFLAR 1.62 0 0.07 0.73819 mirMAP -0.22 4.0E-5 NA
77 hsa-miR-301a-3p CFLAR 1.45 1.0E-5 0.07 0.73819 mirMAP -0.2 1.0E-5 NA
78 hsa-miR-9-5p CFLAR -0.2 0.76147 0.07 0.73819 mirMAP -0.13 0 NA
79 hsa-miR-152-3p CHUK 0.44 0.1617 -0.11 0.43611 MirTarget -0.17 0 NA
80 hsa-miR-195-5p CHUK -0.91 0.00151 -0.11 0.43611 miRNAWalker2 validate; MirTarget -0.13 0.00012 NA
81 hsa-miR-23a-3p CHUK 1.11 0 -0.11 0.43611 MirTarget -0.17 0.00056 NA
82 hsa-miR-23b-3p CHUK -0.29 0.18665 -0.11 0.43611 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 6.0E-5 NA
83 hsa-miR-342-3p CHUK 0.32 0.26915 -0.11 0.43611 miRanda -0.19 0 NA
84 hsa-miR-497-5p CHUK -0.8 0.0036 -0.11 0.43611 MirTarget -0.11 0.00273 NA
85 hsa-miR-15b-3p CSF2RB 1.76 0 -0.2 0.59657 mirMAP -0.31 0.00012 NA
86 hsa-miR-30b-3p CSF2RB -0.27 0.40085 -0.2 0.59657 MirTarget -0.25 0.00393 NA
87 hsa-miR-452-3p CSF2RB 2.2 0.00185 -0.2 0.59657 mirMAP -0.13 0.00156 NA
88 hsa-miR-342-3p CYCS 0.32 0.26915 0.2 0.35913 mirMAP -0.21 8.0E-5 NA
89 hsa-miR-342-3p DFFA 0.32 0.26915 0.01 0.93424 mirMAP -0.1 0.0044 NA
90 hsa-miR-199a-5p DFFB 0.37 0.23266 0.21 0.40784 miRanda -0.2 0.00056 NA
91 hsa-miR-199b-5p DFFB 0.12 0.67816 0.21 0.40784 miRanda -0.16 0.0085 NA
92 hsa-miR-365a-3p DFFB -0.89 0.00255 0.21 0.40784 MirTarget -0.41 0 NA
93 hsa-miR-130b-3p ENDOD1 1.33 5.0E-5 0.17 0.52052 MirTarget -0.22 0.00011 NA
94 hsa-miR-16-1-3p ENDOD1 1.43 0 0.17 0.52052 mirMAP -0.21 0.0029 NA
95 hsa-miR-181b-5p ENDOD1 1.64 0 0.17 0.52052 MirTarget -0.17 0.00661 NA
96 hsa-miR-181c-5p ENDOD1 0.34 0.11293 0.17 0.52052 MirTarget -0.27 0.00393 NA
97 hsa-miR-181d-5p ENDOD1 0.65 0.01434 0.17 0.52052 MirTarget -0.21 0.00307 NA
98 hsa-miR-19a-3p ENDOD1 1.27 0.00011 0.17 0.52052 mirMAP -0.27 0 NA
99 hsa-miR-19b-3p ENDOD1 0.76 0.00653 0.17 0.52052 mirMAP -0.33 0 NA
100 hsa-miR-20a-3p ENDOD1 1.14 0.00045 0.17 0.52052 MirTarget -0.24 4.0E-5 NA
101 hsa-miR-26b-3p ENDOD1 -0.01 0.96577 0.17 0.52052 mirMAP -0.39 0 NA
102 hsa-miR-301a-3p ENDOD1 1.45 1.0E-5 0.17 0.52052 MirTarget -0.17 0.00291 NA
103 hsa-miR-326 ENDOD1 -0.43 0.26299 0.17 0.52052 miRanda -0.18 0.00037 NA
104 hsa-miR-335-3p ENDOD1 2.52 0 0.17 0.52052 MirTarget -0.18 4.0E-5 NA
105 hsa-miR-3607-3p ENDOD1 0.52 0.08425 0.17 0.52052 MirTarget; miRNATAP -0.25 7.0E-5 NA
106 hsa-miR-361-5p ENDOD1 0.41 0.01813 0.17 0.52052 MirTarget; miRanda -0.42 0.00025 NA
107 hsa-miR-3613-5p ENDOD1 1.12 0.00025 0.17 0.52052 MirTarget -0.25 4.0E-5 NA
108 hsa-miR-450b-5p ENDOD1 0.46 0.13274 0.17 0.52052 MirTarget; mirMAP -0.17 0.00608 NA
109 hsa-miR-454-3p ENDOD1 0.63 0.01349 0.17 0.52052 MirTarget -0.41 0 NA
110 hsa-miR-589-3p ENDOD1 1.02 0.00578 0.17 0.52052 mirMAP -0.23 1.0E-5 NA
111 hsa-miR-589-5p ENDOD1 0.7 0.00396 0.17 0.52052 MirTarget -0.32 5.0E-5 NA
112 hsa-miR-590-3p ENDOD1 1.12 0.00016 0.17 0.52052 miRanda -0.27 2.0E-5 NA
113 hsa-miR-149-5p EXOG 0.71 0.29685 -0.16 0.33475 MirTarget -0.1 0 NA
114 hsa-miR-24-3p EXOG 1.09 0 -0.16 0.33475 MirTarget -0.21 0.00012 NA
115 hsa-miR-129-5p FADD -2.57 0 1.34 0.00032 miRanda -0.17 0.00032 NA
116 hsa-miR-7-5p FADD 1.64 0.01244 1.34 0.00032 miRNAWalker2 validate -0.12 0.00377 NA
117 hsa-miR-106a-5p FAS -0.17 0.64287 0.66 0.0207 miRNAWalker2 validate; miRTarBase -0.16 0.00429 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
118 hsa-miR-129-5p FAS -2.57 0 0.66 0.0207 miRanda -0.12 0.0007 NA
119 hsa-miR-92b-3p FASLG 1.34 0 0.49 0.39 miRNATAP -0.54 0.00016 NA
120 hsa-miR-125a-3p IKBKB 1.2 0.00164 0.13 0.50747 miRanda -0.13 0.00065 NA
121 hsa-miR-543 IKBKB 0.03 0.92946 0.13 0.50747 miRanda -0.13 0.00308 NA
122 hsa-miR-125a-5p IKBKG -0.88 0.00021 0.48 0.00797 miRanda -0.24 1.0E-5 NA
123 hsa-miR-148a-3p IKBKG -1.54 4.0E-5 0.48 0.00797 mirMAP -0.12 0.00063 NA
124 hsa-miR-191-5p IL1A 0.96 0.00071 3.99 1.0E-5 miRNAWalker2 validate -0.7 0.00262 NA
125 hsa-miR-200a-3p IL1A 0.72 0.19391 3.99 1.0E-5 MirTarget -0.34 0.00439 NA
126 hsa-miR-30a-5p IL1A -1.72 0 3.99 1.0E-5 MirTarget -0.81 2.0E-5 NA
127 hsa-miR-30b-5p IL1A -0.43 0.05936 3.99 1.0E-5 MirTarget -0.95 0.00124 NA
128 hsa-miR-30c-5p IL1A -0.98 5.0E-5 3.99 1.0E-5 MirTarget -1.12 3.0E-5 NA
129 hsa-miR-30d-5p IL1A -0.55 0.01401 3.99 1.0E-5 MirTarget -1.7 0 NA
130 hsa-miR-30e-5p IL1A -0.57 0.01125 3.99 1.0E-5 MirTarget -0.83 0.00482 NA
131 hsa-miR-532-5p IL1A 0.31 0.25225 3.99 1.0E-5 MirTarget -1.08 1.0E-5 NA
132 hsa-miR-664a-3p IL1A -0.83 0.00014 3.99 1.0E-5 MirTarget -0.9 0.00323 NA
133 hsa-miR-30a-3p IL1B -1.73 0 1.27 0.03288 MirTarget -0.44 0.00032 NA
134 hsa-miR-126-5p IL1R1 0.42 0.07532 -0.91 0.00472 mirMAP -0.26 0.0085 NA
135 hsa-miR-130b-5p IL1R1 0.7 0.05101 -0.91 0.00472 mirMAP -0.37 0 NA
136 hsa-miR-17-3p IL1R1 1.31 0 -0.91 0.00472 mirMAP -0.69 0 NA
137 hsa-miR-186-5p IL1R1 0.15 0.43471 -0.91 0.00472 mirMAP -0.44 0.00029 NA
138 hsa-miR-197-3p IL1R1 0.89 0.0002 -0.91 0.00472 miRNAWalker2 validate -0.5 0 NA
139 hsa-miR-24-3p IL1R1 1.09 0 -0.91 0.00472 miRNATAP -0.42 4.0E-5 NA
140 hsa-miR-26b-5p IL1R1 -0.3 0.16008 -0.91 0.00472 mirMAP -0.46 2.0E-5 NA
141 hsa-miR-30d-3p IL1R1 -0.55 0.04337 -0.91 0.00472 mirMAP -0.23 0.0072 NA
142 hsa-miR-335-3p IL1R1 2.52 0 -0.91 0.00472 mirMAP -0.32 0 NA
143 hsa-miR-361-5p IL1R1 0.41 0.01813 -0.91 0.00472 miRanda -0.65 0 NA
144 hsa-miR-3662 IL1R1 1.83 0.0054 -0.91 0.00472 mirMAP -0.14 0.00185 NA
145 hsa-miR-590-3p IL1R1 1.12 0.00016 -0.91 0.00472 miRanda; miRNATAP -0.32 2.0E-5 NA
146 hsa-miR-107 IL1RAP 0.9 5.0E-5 1.2 0.00709 miRanda -0.72 0 NA
147 hsa-miR-139-5p IL1RAP -1.83 0 1.2 0.00709 miRanda -0.27 0.00747 NA
148 hsa-miR-140-5p IL1RAP 0.21 0.303 1.2 0.00709 miRanda -0.51 0.0015 NA
149 hsa-miR-186-5p IL1RAP 0.15 0.43471 1.2 0.00709 mirMAP -0.54 0.00161 NA
150 hsa-miR-190a-5p IL1RAP -0.74 0.06624 1.2 0.00709 MirTarget -0.39 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 41 1929 1.747e-28 8.127e-25
2 INTRACELLULAR SIGNAL TRANSDUCTION 37 1572 1.475e-26 3.431e-23
3 POSITIVE REGULATION OF MOLECULAR FUNCTION 37 1791 1.501e-24 2.329e-21
4 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 36 1848 7.322e-23 8.517e-20
5 APOPTOTIC SIGNALING PATHWAY 20 289 1.371e-22 1.276e-19
6 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 15 99 2.897e-22 1.925e-19
7 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 33 1492 2.657e-22 1.925e-19
8 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 34 1656 4.635e-22 2.696e-19
9 REGULATION OF CELL DEATH 32 1472 2.745e-21 1.419e-18
10 CELL DEATH 28 1001 3.314e-21 1.542e-18
11 POSITIVE REGULATION OF CELL COMMUNICATION 32 1532 9.18e-21 3.883e-18
12 IMMUNE SYSTEM PROCESS 35 1984 1.138e-20 4.385e-18
13 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 14 95 1.225e-20 4.385e-18
14 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 26 876 3.318e-20 1.103e-17
15 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 16 179 6.732e-20 2.088e-17
16 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 11 39 8.619e-20 2.507e-17
17 RESPONSE TO OXYGEN CONTAINING COMPOUND 30 1381 9.246e-20 2.531e-17
18 POSITIVE REGULATION OF CATALYTIC ACTIVITY 31 1518 9.919e-20 2.564e-17
19 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 17 233 1.339e-19 3.232e-17
20 ZYMOGEN ACTIVATION 14 112 1.389e-19 3.232e-17
21 ACTIVATION OF IMMUNE RESPONSE 20 427 3.238e-19 7.175e-17
22 REGULATION OF IMMUNE RESPONSE 25 858 3.481e-19 7.363e-17
23 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 16 213 1.136e-18 2.299e-16
24 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 13 98 1.383e-18 2.682e-16
25 REGULATION OF IMMUNE SYSTEM PROCESS 29 1403 1.962e-18 3.652e-16
26 POSITIVE REGULATION OF IMMUNE RESPONSE 21 563 3.646e-18 6.526e-16
27 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 13 4.45e-18 7.669e-16
28 NEGATIVE REGULATION OF CELL DEATH 24 872 8.277e-18 1.375e-15
29 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 153 1.269e-17 2.036e-15
30 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 14 154 1.393e-17 2.16e-15
31 POSITIVE REGULATION OF CELL DEATH 21 605 1.569e-17 2.355e-15
32 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 17 323 3.415e-17 4.965e-15
33 PROTEIN MATURATION 16 265 3.779e-17 5.329e-15
34 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 17 8.33e-17 1.14e-14
35 RESPONSE TO NITROGEN COMPOUND 23 859 8.994e-17 1.196e-14
36 RESPONSE TO CYTOKINE 21 714 4.379e-16 5.66e-14
37 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 14 200 5.663e-16 7.122e-14
38 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 22 1.083e-15 1.327e-13
39 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 22 867 1.554e-15 1.854e-13
40 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 21 799 4.09e-15 4.758e-13
41 REGULATION OF APOPTOTIC SIGNALING PATHWAY 16 363 5.39e-15 6.117e-13
42 REGULATION OF PROTEOLYSIS 20 711 6.07e-15 6.725e-13
43 RESPONSE TO ENDOGENOUS STIMULUS 26 1450 7.2e-15 7.791e-13
44 FC EPSILON RECEPTOR SIGNALING PATHWAY 12 142 8.611e-15 9.107e-13
45 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 11 109 1.691e-14 1.748e-12
46 REGULATION OF PEPTIDASE ACTIVITY 16 392 1.781e-14 1.776e-12
47 PHOSPHORYLATION 24 1228 1.794e-14 1.776e-12
48 ACTIVATION OF INNATE IMMUNE RESPONSE 13 204 2.361e-14 2.288e-12
49 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 8 33 4.588e-14 4.269e-12
50 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 8 33 4.588e-14 4.269e-12
51 TOLL LIKE RECEPTOR SIGNALING PATHWAY 10 85 5.906e-14 5.356e-12
52 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 34 5.986e-14 5.356e-12
53 NEURON APOPTOTIC PROCESS 8 35 7.742e-14 6.797e-12
54 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 12 171 8.168e-14 7.038e-12
55 POSITIVE REGULATION OF PROTEOLYSIS 15 363 1.108e-13 9.376e-12
56 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 13 246 2.631e-13 2.186e-11
57 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 12 195 3.938e-13 3.215e-11
58 REGULATION OF KINASE ACTIVITY 19 776 4.02e-13 3.225e-11
59 RESPONSE TO ABIOTIC STIMULUS 21 1024 5.191e-13 4.094e-11
60 FC RECEPTOR SIGNALING PATHWAY 12 206 7.569e-13 5.87e-11
61 REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1618 8.494e-13 6.479e-11
62 REGULATION OF RESPONSE TO STRESS 24 1468 8.79e-13 6.492e-11
63 CELLULAR RESPONSE TO NITROGEN COMPOUND 16 505 8.71e-13 6.492e-11
64 NEURON DEATH 8 47 1.007e-12 7.318e-11
65 PROTEIN PHOSPHORYLATION 20 944 1.2e-12 8.592e-11
66 REGULATION OF TRANSFERASE ACTIVITY 20 946 1.248e-12 8.797e-11
67 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 27 1977 1.281e-12 8.893e-11
68 ACTIVATION OF PROTEIN KINASE ACTIVITY 13 279 1.308e-12 8.953e-11
69 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 7 28 1.518e-12 1.024e-10
70 REGULATION OF INNATE IMMUNE RESPONSE 14 357 1.664e-12 1.106e-10
71 POSITIVE REGULATION OF DEFENSE RESPONSE 14 364 2.163e-12 1.417e-10
72 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 21 1135 3.723e-12 2.406e-10
73 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 55 3.827e-12 2.439e-10
74 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 10 132 5.302e-12 3.334e-10
75 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 7 33 5.414e-12 3.359e-10
76 POSITIVE REGULATION OF KINASE ACTIVITY 15 482 6.532e-12 3.917e-10
77 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 20 1036 6.566e-12 3.917e-10
78 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1036 6.566e-12 3.917e-10
79 RESPONSE TO PEPTIDE 14 404 8.767e-12 5.164e-10
80 HOMEOSTATIC PROCESS 22 1337 9.797e-12 5.698e-10
81 CELLULAR RESPONSE TO CYTOKINE STIMULUS 16 606 1.36e-11 7.718e-10
82 CELLULAR RESPONSE TO ABIOTIC STIMULUS 12 263 1.346e-11 7.718e-10
83 T CELL RECEPTOR SIGNALING PATHWAY 10 146 1.457e-11 8.169e-10
84 CYTOKINE MEDIATED SIGNALING PATHWAY 14 452 3.904e-11 2.163e-09
85 RESPONSE TO BIOTIC STIMULUS 18 886 4.239e-11 2.321e-09
86 RESPONSE TO HORMONE 18 893 4.822e-11 2.609e-09
87 CELLULAR GLUCOSE HOMEOSTASIS 8 75 5.068e-11 2.71e-09
88 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 228 5.746e-11 3.038e-09
89 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 8.202e-11 4.288e-09
90 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 1.05e-10 5.427e-09
91 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 12 321 1.357e-10 6.94e-09
92 REGULATION OF PROTEIN MODIFICATION PROCESS 23 1710 1.654e-10 8.366e-09
93 REGULATION OF NEURON DEATH 11 252 1.677e-10 8.392e-09
94 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 15 616 2.048e-10 1.014e-08
95 CHEMICAL HOMEOSTASIS 17 874 3.263e-10 1.598e-08
96 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 18 1008 3.449e-10 1.672e-08
97 REGULATION OF DEFENSE RESPONSE 16 759 3.777e-10 1.812e-08
98 CELLULAR RESPONSE TO PEPTIDE 11 274 4.084e-10 1.939e-08
99 CELLULAR RESPONSE TO HORMONE STIMULUS 14 552 5.368e-10 2.523e-08
100 POSITIVE REGULATION OF HYDROLASE ACTIVITY 17 905 5.567e-10 2.59e-08
101 RESPONSE TO EXTERNAL STIMULUS 23 1821 5.76e-10 2.654e-08
102 INTRINSIC APOPTOTIC SIGNALING PATHWAY 9 152 6.057e-10 2.763e-08
103 RESPONSE TO WOUNDING 14 563 6.934e-10 3.132e-08
104 PROTEOLYSIS 19 1208 8.285e-10 3.707e-08
105 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 20 1360 8.401e-10 3.723e-08
106 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 1.131e-09 4.966e-08
107 REGULATION OF CATABOLIC PROCESS 15 731 2.149e-09 9.345e-08
108 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 2.278e-09 9.816e-08
109 RESPONSE TO BACTERIUM 13 528 3.485e-09 1.488e-07
110 CELLULAR RESPONSE TO MECHANICAL STIMULUS 7 80 3.617e-09 1.53e-07
111 REGULATION OF HYDROLASE ACTIVITY 19 1327 3.938e-09 1.651e-07
112 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 6 46 4.338e-09 1.802e-07
113 REGULATION OF NEURON APOPTOTIC PROCESS 9 192 4.767e-09 1.963e-07
114 MULTICELLULAR ORGANISMAL HOMEOSTASIS 10 272 6.414e-09 2.618e-07
115 INFLAMMATORY RESPONSE 12 454 6.901e-09 2.792e-07
116 REGULATION OF EXECUTION PHASE OF APOPTOSIS 5 24 7.649e-09 3.068e-07
117 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 51 8.247e-09 3.252e-07
118 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 365 8.229e-09 3.252e-07
119 CELL ACTIVATION 13 568 8.341e-09 3.261e-07
120 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 9.035e-09 3.503e-07
121 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 11 370 9.472e-09 3.609e-07
122 CELLULAR RESPONSE TO STRESS 20 1565 9.448e-09 3.609e-07
123 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 9.54e-09 3.609e-07
124 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 8 144 9.659e-09 3.625e-07
125 WOUND HEALING 12 470 1.015e-08 3.747e-07
126 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 12 470 1.015e-08 3.747e-07
127 RESPONSE TO MECHANICAL STIMULUS 9 210 1.042e-08 3.819e-07
128 IMMUNE RESPONSE 17 1100 1.054e-08 3.83e-07
129 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 95 1.216e-08 4.386e-07
130 LEUKOCYTE DIFFERENTIATION 10 292 1.261e-08 4.514e-07
131 RENAL SYSTEM PROCESS 7 102 2e-08 7.103e-07
132 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 6 59 2.026e-08 7.142e-07
133 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 30 2.53e-08 8.852e-07
134 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 7 106 2.615e-08 9.081e-07
135 REGULATION OF CELL PROLIFERATION 19 1496 2.77e-08 9.547e-07
136 RESPONSE TO LIPID 15 888 2.921e-08 9.995e-07
137 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 3.321e-08 1.128e-06
138 RESPONSE TO TOXIC SUBSTANCE 9 241 3.432e-08 1.157e-06
139 GLUCOSE HOMEOSTASIS 8 170 3.542e-08 1.177e-06
140 CARBOHYDRATE HOMEOSTASIS 8 170 3.542e-08 1.177e-06
141 POSITIVE REGULATION OF NEURON DEATH 6 67 4.407e-08 1.454e-06
142 RESPONSE TO ORGANIC CYCLIC COMPOUND 15 917 4.463e-08 1.463e-06
143 RESPONSE TO INTERLEUKIN 1 7 115 4.606e-08 1.499e-06
144 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 4 13 4.787e-08 1.547e-06
145 T CELL HOMEOSTASIS 5 34 4.896e-08 1.56e-06
146 RENAL WATER HOMEOSTASIS 5 34 4.896e-08 1.56e-06
147 LYMPHOCYTE ACTIVATION 10 342 5.602e-08 1.761e-06
148 LEUKOCYTE CELL CELL ADHESION 9 255 5.574e-08 1.761e-06
149 I KAPPAB KINASE NF KAPPAB SIGNALING 6 70 5.75e-08 1.796e-06
150 REGULATION OF CELLULAR PROTEIN LOCALIZATION 12 552 5.956e-08 1.848e-06
151 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 6 71 6.267e-08 1.931e-06
152 CELLULAR HOMEOSTASIS 13 676 6.473e-08 1.982e-06
153 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 6.548e-08 1.991e-06
154 CELLULAR RESPONSE TO EXTERNAL STIMULUS 9 264 7.499e-08 2.266e-06
155 INOSITOL LIPID MEDIATED SIGNALING 7 124 7.753e-08 2.327e-06
156 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 6 74 8.051e-08 2.401e-06
157 CELLULAR CHEMICAL HOMEOSTASIS 12 570 8.444e-08 2.503e-06
158 CELLULAR RESPONSE TO GLUCAGON STIMULUS 5 38 8.753e-08 2.578e-06
159 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 10 360 9.045e-08 2.646e-06
160 T CELL APOPTOTIC PROCESS 4 15 9.098e-08 2.646e-06
161 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 9.466e-08 2.736e-06
162 IMMUNE SYSTEM DEVELOPMENT 12 582 1.058e-07 3.04e-06
163 RESPONSE TO INORGANIC SUBSTANCE 11 479 1.316e-07 3.757e-06
164 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 1.579e-07 4.481e-06
165 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 1.621e-07 4.572e-06
166 LYMPHOCYTE DIFFERENTIATION 8 209 1.746e-07 4.894e-06
167 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 1.878e-07 5.233e-06
168 LYMPHOCYTE APOPTOTIC PROCESS 4 18 2.026e-07 5.612e-06
169 REGULATION OF INTRACELLULAR TRANSPORT 12 621 2.13e-07 5.863e-06
170 CELLULAR RESPONSE TO INTERLEUKIN 1 6 88 2.281e-07 6.244e-06
171 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 220 2.584e-07 7.032e-06
172 PEPTIDYL SERINE MODIFICATION 7 148 2.605e-07 7.048e-06
173 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 47 2.621e-07 7.05e-06
174 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 11 514 2.665e-07 7.125e-06
175 RESPONSE TO GLUCAGON 5 48 2.919e-07 7.762e-06
176 HEMOSTASIS 9 311 3.008e-07 7.952e-06
177 LEUKOCYTE ACTIVATION 10 414 3.294e-07 8.66e-06
178 LYMPHOCYTE HOMEOSTASIS 5 50 3.596e-07 9.296e-06
179 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 5 50 3.596e-07 9.296e-06
180 RESPONSE TO GAMMA RADIATION 5 50 3.596e-07 9.296e-06
181 RESPONSE TO TUMOR NECROSIS FACTOR 8 233 4e-07 1.028e-05
182 POSITIVE REGULATION OF TRANSPORT 14 936 4.073e-07 1.041e-05
183 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 4.268e-07 1.085e-05
184 CELL DEVELOPMENT 17 1426 4.523e-07 1.144e-05
185 LIPID PHOSPHORYLATION 6 99 4.601e-07 1.157e-05
186 RESPONSE TO DRUG 10 431 4.762e-07 1.191e-05
187 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 19 1805 5.325e-07 1.325e-05
188 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 5.799e-07 1.428e-05
189 LEUKOCYTE APOPTOTIC PROCESS 4 23 5.799e-07 1.428e-05
190 EXECUTION PHASE OF APOPTOSIS 5 55 5.838e-07 1.43e-05
191 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 7 168 6.151e-07 1.493e-05
192 POSITIVE REGULATION OF PROTEIN IMPORT 6 104 6.16e-07 1.493e-05
193 RESPONSE TO VIRUS 8 247 6.223e-07 1.5e-05
194 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 5 58 7.638e-07 1.832e-05
195 SINGLE ORGANISM CELL ADHESION 10 459 8.443e-07 2.015e-05
196 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 8 258 8.642e-07 2.052e-05
197 LEUKOCYTE HOMEOSTASIS 5 60 9.064e-07 2.141e-05
198 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1004 9.439e-07 2.218e-05
199 RESPONSE TO AMINO ACID 6 112 9.537e-07 2.23e-05
200 DEVELOPMENTAL PROGRAMMED CELL DEATH 4 26 9.727e-07 2.252e-05
201 REGULATION OF NECROTIC CELL DEATH 4 26 9.727e-07 2.252e-05
202 AGING 8 264 1.027e-06 2.366e-05
203 RESPONSE TO KETONE 7 182 1.054e-06 2.415e-05
204 REGULATION OF PROTEIN IMPORT 7 183 1.093e-06 2.493e-05
205 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 1.289e-06 2.926e-05
206 NECROTIC CELL DEATH 4 28 1.326e-06 2.996e-05
207 IMMUNE EFFECTOR PROCESS 10 486 1.415e-06 3.18e-05
208 RESPONSE TO REACTIVE OXYGEN SPECIES 7 191 1.455e-06 3.255e-05
209 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 381 1.63e-06 3.629e-05
210 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 8 282 1.683e-06 3.728e-05
211 DEFENSE RESPONSE 15 1231 1.938e-06 4.274e-05
212 WATER HOMEOSTASIS 5 70 1.964e-06 4.29e-05
213 REGULATION OF MEMBRANE PERMEABILITY 5 70 1.964e-06 4.29e-05
214 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 2.181e-06 4.726e-05
215 NEGATIVE REGULATION OF CATABOLIC PROCESS 7 203 2.184e-06 4.726e-05
216 NEGATIVE REGULATION OF MOLECULAR FUNCTION 14 1079 2.211e-06 4.763e-05
217 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 32 2.309e-06 4.883e-05
218 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 32 2.309e-06 4.883e-05
219 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 2.309e-06 4.883e-05
220 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 4 32 2.309e-06 4.883e-05
221 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 2.474e-06 5.209e-05
222 B CELL ACTIVATION 6 132 2.494e-06 5.227e-05
223 REGULATION OF PROTEIN LOCALIZATION 13 950 3.056e-06 6.376e-05
224 RESPONSE TO RADIATION 9 413 3.155e-06 6.539e-05
225 REGULATION OF PROTEIN TARGETING 8 307 3.162e-06 6.539e-05
226 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 13 957 3.312e-06 6.82e-05
227 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 3.501e-06 7.176e-05
228 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 3.749e-06 7.651e-05
229 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 3.814e-06 7.75e-05
230 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 3.957e-06 8.004e-05
231 RESPONSE TO ACID CHEMICAL 8 319 4.196e-06 8.415e-05
232 REGULATION OF MAP KINASE ACTIVITY 8 319 4.196e-06 8.415e-05
233 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 5.766e-06 0.0001151
234 REGULATION OF ORGANELLE ORGANIZATION 14 1178 6.127e-06 0.0001218
235 RESPONSE TO COBALT ION 3 13 6.829e-06 0.0001352
236 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 7.03e-06 0.0001386
237 MITOCHONDRIAL MEMBRANE ORGANIZATION 5 92 7.594e-06 0.0001491
238 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 43 7.734e-06 0.0001506
239 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 4 43 7.734e-06 0.0001506
240 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 9 465 8.232e-06 0.0001596
241 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 3 14 8.673e-06 0.0001661
242 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 3 14 8.673e-06 0.0001661
243 RESPONSE TO OXIDATIVE STRESS 8 352 8.625e-06 0.0001661
244 POSITIVE REGULATION OF MAPK CASCADE 9 470 8.969e-06 0.000171
245 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 9.055e-06 0.000172
246 GLYCEROLIPID METABOLIC PROCESS 8 356 9.363e-06 0.0001771
247 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1784 9.723e-06 0.0001832
248 RESPONSE TO CARBOHYDRATE 6 168 1.001e-05 0.0001879
249 CELL CELL ADHESION 10 608 1.027e-05 0.000192
250 LEUKOCYTE MIGRATION 7 259 1.082e-05 0.0002014
251 PHOSPHOLIPID METABOLIC PROCESS 8 364 1.1e-05 0.000204
252 NEGATIVE REGULATION OF NEURON DEATH 6 171 1.108e-05 0.0002045
253 REGULATION OF CELL ACTIVATION 9 484 1.134e-05 0.0002086
254 REGULATION OF GLUCOSE TRANSPORT 5 100 1.142e-05 0.0002092
255 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.206e-05 0.0002201
256 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 8 372 1.288e-05 0.000234
257 RESPONSE TO CORTICOSTEROID 6 176 1.305e-05 0.0002363
258 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 13 1087 1.314e-05 0.0002369
259 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 103 1.319e-05 0.0002369
260 REGULATION OF CELLULAR LOCALIZATION 14 1277 1.535e-05 0.0002746
261 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 17 1.61e-05 0.0002856
262 REGULATION OF BODY FLUID LEVELS 9 506 1.614e-05 0.0002856
263 NEGATIVE REGULATION OF ANOIKIS 3 17 1.61e-05 0.0002856
264 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 1.795e-05 0.0003164
265 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 1.928e-05 0.0003385
266 REGULATION OF CELL DIFFERENTIATION 15 1492 1.996e-05 0.0003491
267 REGULATION OF MAPK CASCADE 10 660 2.087e-05 0.0003637
268 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 2.285e-05 0.0003967
269 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 8 404 2.33e-05 0.0004031
270 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 13 1152 2.429e-05 0.0004187
271 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 5 118 2.549e-05 0.0004376
272 REGULATION OF GLUCOSE IMPORT 4 60 2.944e-05 0.0005036
273 RESPONSE TO INSULIN 6 205 3.09e-05 0.0005266
274 NECROPTOTIC PROCESS 3 21 3.123e-05 0.0005284
275 T CELL DIFFERENTIATION 5 123 3.112e-05 0.0005284
276 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 3.144e-05 0.00053
277 RESPONSE TO UV 5 126 3.494e-05 0.0005848
278 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 126 3.494e-05 0.0005848
279 RESPONSE TO OXYGEN LEVELS 7 311 3.507e-05 0.0005848
280 LIPID MODIFICATION 6 210 3.536e-05 0.0005876
281 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 22 3.608e-05 0.0005975
282 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 437 4.072e-05 0.0006719
283 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 14 1395 4.102e-05 0.0006744
284 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 9 573 4.28e-05 0.0007012
285 REGULATION OF MITOCHONDRION ORGANIZATION 6 218 4.357e-05 0.0007114
286 REGULATION OF ANOIKIS 3 24 4.723e-05 0.0007683
287 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 4.861e-05 0.0007881
288 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 5.007e-05 0.000809
289 RESPONSE TO ALKALOID 5 137 5.214e-05 0.0008366
290 CELLULAR RESPONSE TO RADIATION 5 137 5.214e-05 0.0008366
291 EMBRYO DEVELOPMENT 11 894 5.233e-05 0.0008367
292 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 138 5.398e-05 0.0008584
293 RESPONSE TO METAL ION 7 333 5.406e-05 0.0008584
294 MITOCHONDRION ORGANIZATION 9 594 5.654e-05 0.0008948
295 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 6.267e-05 0.0009885
296 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 233 6.306e-05 0.0009911
297 CELLULAR LIPID METABOLIC PROCESS 11 913 6.326e-05 0.0009911
298 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 6.737e-05 0.001052
299 DNA CATABOLIC PROCESS 3 27 6.782e-05 0.001055
300 RESPONSE TO IONIZING RADIATION 5 145 6.83e-05 0.001059
301 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 7.056e-05 0.001091
302 RESPONSE TO TEMPERATURE STIMULUS 5 148 7.526e-05 0.00116
303 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 8.437e-05 0.001287
304 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 8.437e-05 0.001287
305 MUSCLE ADAPTATION 3 29 8.437e-05 0.001287
306 REGULATION OF CELL ADHESION 9 629 8.769e-05 0.001333
307 REGULATION OF AUTOPHAGY 6 249 9.096e-05 0.001378
308 RESPONSE TO ALCOHOL 7 362 9.124e-05 0.001378
309 RESPONSE TO STEROID HORMONE 8 497 0.0001002 0.001508
310 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 0.0001034 0.001551
311 CELLULAR RESPONSE TO BIOTIC STIMULUS 5 163 0.0001187 0.001775
312 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 0.0001214 0.00181
313 INTERSPECIES INTERACTION BETWEEN ORGANISMS 9 662 0.0001292 0.001915
314 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 9 662 0.0001292 0.001915
315 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 0.0001324 0.001956
316 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 5 167 0.000133 0.001958
317 PROTEIN KINASE B SIGNALING 3 34 0.0001367 0.002007
318 B CELL DIFFERENTIATION 4 89 0.0001383 0.002024
319 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 10 829 0.0001409 0.002056
320 CALCIUM MEDIATED SIGNALING 4 90 0.0001444 0.0021
321 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 0.0001568 0.002266
322 GLAND DEVELOPMENT 7 395 0.0001566 0.002266
323 HOMEOSTASIS OF NUMBER OF CELLS 5 175 0.0001655 0.002376
324 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 9 684 0.0001652 0.002376
325 MITOCHONDRIAL TRANSPORT 5 177 0.0001745 0.002496
326 LIPID BIOSYNTHETIC PROCESS 8 539 0.0001749 0.002496
327 REGULATION OF TRANSPORT 15 1804 0.0001757 0.0025
328 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 0.000178 0.002525
329 REGULATION OF LIPID METABOLIC PROCESS 6 282 0.0001794 0.002529
330 MUSCLE SYSTEM PROCESS 6 282 0.0001794 0.002529
331 FEMALE GAMETE GENERATION 4 96 0.0001853 0.002605
332 BIOLOGICAL ADHESION 11 1032 0.0001873 0.002625
333 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 0.0002038 0.002847
334 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 0.0002048 0.002853
335 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0002066 0.002862
336 SPLEEN DEVELOPMENT 3 39 0.0002066 0.002862
337 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 8 554 0.0002108 0.002911
338 REGULATION OF CELL CYCLE PROCESS 8 558 0.0002214 0.003047
339 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0002229 0.00306
340 MYELOID CELL DIFFERENTIATION 5 189 0.0002366 0.003238
341 PROTEIN DEPHOSPHORYLATION 5 190 0.0002425 0.003309
342 NEGATIVE REGULATION OF CELL CYCLE 7 433 0.0002744 0.003734
343 REGULATION OF HOMOTYPIC CELL CELL ADHESION 6 307 0.0002834 0.003844
344 REGULATION OF CELL CYCLE ARREST 4 108 0.0002912 0.003939
345 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 44 0.0002963 0.003997
346 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.0003016 0.004057
347 POSITIVE REGULATION OF CELL ACTIVATION 6 311 0.0003037 0.004072
348 THYMOCYTE AGGREGATION 3 45 0.0003168 0.004224
349 T CELL DIFFERENTIATION IN THYMUS 3 45 0.0003168 0.004224
350 REGULATION OF HEMOPOIESIS 6 314 0.0003196 0.004249
351 REGULATION OF HOMEOSTATIC PROCESS 7 447 0.0003326 0.004409
352 GAMETE GENERATION 8 595 0.000341 0.004508
353 OVULATION CYCLE 4 113 0.0003461 0.004562
354 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 0.000352 0.004626
355 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 0.0003599 0.004712
356 RESPONSE TO ANTIBIOTIC 3 47 0.0003605 0.004712
357 TUBE MORPHOGENESIS 6 323 0.0003715 0.004843
358 GERM CELL DEVELOPMENT 5 209 0.0003761 0.004888
359 CELLULAR RESPONSE TO LIPID 7 457 0.00038 0.004925
360 FEMALE SEX DIFFERENTIATION 4 116 0.0003823 0.004942
361 MULTICELLULAR ORGANISM REPRODUCTION 9 768 0.0003891 0.005015
362 TISSUE DEVELOPMENT 13 1518 0.0003935 0.005058
363 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 118 0.000408 0.005229
364 REGULATION OF CELL CYCLE 10 949 0.0004173 0.005335
365 INNATE IMMUNE RESPONSE 8 619 0.0004437 0.005657
366 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 11 1142 0.0004469 0.005681
367 RESPONSE TO ESTROGEN 5 218 0.000456 0.005781
368 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 0.0004629 0.005837
369 REGULATION OF NECROPTOTIC PROCESS 2 11 0.0004626 0.005837
370 REGULATION OF DNA METABOLIC PROCESS 6 340 0.0004875 0.006097
371 REGULATION OF T CELL MEDIATED IMMUNITY 3 52 0.0004863 0.006097
372 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 52 0.0004863 0.006097
373 LIPID METABOLIC PROCESS 11 1158 0.0005025 0.006269
374 CELLULAR RESPONSE TO AMINO ACID STIMULUS 3 53 0.0005144 0.0064
375 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 9 801 0.0005279 0.006551
376 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0005435 0.006673
377 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 54 0.0005435 0.006673
378 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.0005435 0.006673
379 B CELL RECEPTOR SIGNALING PATHWAY 3 54 0.0005435 0.006673
380 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.000554 0.006713
381 SYSTEM PROCESS 14 1785 0.0005513 0.006713
382 I KAPPAB PHOSPHORYLATION 2 12 0.000554 0.006713
383 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.000554 0.006713
384 POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS 2 12 0.000554 0.006713
385 REGULATION OF LEUKOCYTE DIFFERENTIATION 5 232 0.0006049 0.007311
386 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 7 498 0.0006338 0.007641
387 APOPTOTIC MITOCHONDRIAL CHANGES 3 57 0.0006371 0.00766
388 HEPATOCYTE APOPTOTIC PROCESS 2 13 0.0006535 0.007737
389 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 2 13 0.0006535 0.007737
390 REGULATION OF HISTONE PHOSPHORYLATION 2 13 0.0006535 0.007737
391 PROTEIN AUTOPROCESSING 2 13 0.0006535 0.007737
392 POSITIVE REGULATION OF MACROPHAGE DIFFERENTIATION 2 13 0.0006535 0.007737
393 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0006535 0.007737
394 MUSCLE CELL DIFFERENTIATION 5 237 0.0006661 0.007866
395 POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 3 58 0.0006705 0.007898
396 CELL MOTILITY 9 835 0.0007114 0.008338
397 LOCALIZATION OF CELL 9 835 0.0007114 0.008338
398 ACTIVATION OF MAPK ACTIVITY 4 137 0.0007162 0.008373
399 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 0.0007455 0.008694
400 CELL PROLIFERATION 8 672 0.0007612 0.00881
401 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 2 14 0.000761 0.00881
402 POSITIVE REGULATION OF CYTOKINE PRODUCTION 6 370 0.0007591 0.00881
403 CELLULAR COMPONENT DISASSEMBLY 7 515 0.0007723 0.008917
404 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0007772 0.008929
405 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 3 61 0.0007772 0.008929
406 POSITIVE REGULATION OF CELL CYCLE PROCESS 5 247 0.0008022 0.009194
407 PLATELET ACTIVATION 4 142 0.0008189 0.009362
408 NEGATIVE REGULATION OF KINASE ACTIVITY 5 250 0.0008469 0.009658
409 REGULATION OF CELL CELL ADHESION 6 380 0.0008718 0.009918
410 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.0008764 0.009922
411 APOPTOTIC DNA FRAGMENTATION 2 15 0.0008764 0.009922
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 20 842 1.449e-13 1.346e-10
2 ENZYME BINDING 26 1737 5.001e-13 2.323e-10
3 CYTOKINE RECEPTOR BINDING 13 271 9.043e-13 2.338e-10
4 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 8 47 1.007e-12 2.338e-10
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 20 992 2.978e-12 5.533e-10
6 DEATH RECEPTOR BINDING 6 18 9.164e-12 1.419e-09
7 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 2.868e-11 3.806e-09
8 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 3.992e-11 4.636e-09
9 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 1.408e-10 1.454e-08
10 UBIQUITIN LIKE PROTEIN LIGASE BINDING 11 264 2.752e-10 2.557e-08
11 PROTEIN SERINE THREONINE KINASE ACTIVITY 13 445 4.394e-10 3.711e-08
12 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 5 15 5.515e-10 4.27e-08
13 PROTEIN HETERODIMERIZATION ACTIVITY 13 468 8.119e-10 5.802e-08
14 PROTEIN DOMAIN SPECIFIC BINDING 14 624 2.609e-09 1.731e-07
15 PROTEIN KINASE ACTIVITY 14 640 3.606e-09 2.234e-07
16 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 7 86 6.035e-09 3.504e-07
17 KINASE BINDING 13 606 1.797e-08 9.821e-07
18 TUMOR NECROSIS FACTOR RECEPTOR BINDING 5 30 2.53e-08 1.306e-06
19 ADENYL NUCLEOTIDE BINDING 19 1514 3.357e-08 1.641e-06
20 KINASE REGULATOR ACTIVITY 8 186 7.117e-08 3.306e-06
21 INTERLEUKIN 1 RECEPTOR BINDING 4 16 1.21e-07 5.355e-06
22 PROTEIN DIMERIZATION ACTIVITY 16 1149 1.335e-07 5.638e-06
23 PROTEASE BINDING 6 104 6.16e-07 2.488e-05
24 RIBONUCLEOTIDE BINDING 19 1860 8.434e-07 3.265e-05
25 CYSTEINE TYPE PEPTIDASE ACTIVITY 7 184 1.134e-06 4.213e-05
26 IDENTICAL PROTEIN BINDING 15 1209 1.548e-06 5.533e-05
27 ENZYME REGULATOR ACTIVITY 13 959 3.389e-06 0.0001166
28 RECEPTOR BINDING 16 1476 3.74e-06 0.0001241
29 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 3.957e-06 0.0001267
30 MOLECULAR FUNCTION REGULATOR 15 1353 6.187e-06 0.0001916
31 PROTEIN KINASE A BINDING 4 42 7.03e-06 0.0002107
32 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 3 15 1.082e-05 0.0003141
33 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 1.329e-05 0.0003741
34 PROTEIN COMPLEX BINDING 12 935 1.489e-05 0.0004069
35 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 3.803e-05 0.001009
36 GROWTH FACTOR RECEPTOR BINDING 5 129 3.911e-05 0.001009
37 CAMP BINDING 3 23 4.141e-05 0.00104
38 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 3 30 9.355e-05 0.002287
39 CYCLIC NUCLEOTIDE BINDING 3 36 0.0001625 0.00387
40 PROTEIN HOMODIMERIZATION ACTIVITY 9 722 0.0002471 0.00574
41 SCAFFOLD PROTEIN BINDING 3 45 0.0003168 0.007179
42 ENDOPEPTIDASE ACTIVITY 7 448 0.0003371 0.007457
43 PROTEIN PHOSPHATASE BINDING 4 120 0.0004348 0.009394
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 237 2.053e-16 1.199e-13
2 CATALYTIC COMPLEX 23 1038 5.332e-15 1.557e-12
3 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 1.012e-13 1.97e-11
4 MEMBRANE MICRODOMAIN 12 288 3.875e-11 5.513e-09
5 MEMBRANE PROTEIN COMPLEX 19 1020 4.72e-11 5.513e-09
6 PROTEIN KINASE COMPLEX 8 90 2.25e-10 2.19e-08
7 TRANSFERASE COMPLEX 15 703 1.262e-09 1.053e-07
8 CILIARY BASE 5 23 6.069e-09 4.431e-07
9 CYTOSOLIC PART 9 223 1.756e-08 1.139e-06
10 IKAPPAB KINASE COMPLEX 3 11 3.957e-06 0.0002311
11 EXTRINSIC COMPONENT OF MEMBRANE 7 252 9.055e-06 0.0004807
12 PHOSPHATASE COMPLEX 4 48 1.206e-05 0.000587
13 PLASMA MEMBRANE PROTEIN COMPLEX 9 510 1.718e-05 0.0007719
14 MEMBRANE REGION 13 1134 2.058e-05 0.0008586
15 PERINUCLEAR REGION OF CYTOPLASM 9 642 0.0001025 0.003989
16 PLASMA MEMBRANE RAFT 4 86 0.0001211 0.00442

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 59 89 1.176e-150 2.117e-148
2 hsa04620_Toll.like_receptor_signaling_pathway 19 102 5.591e-30 3.842e-28
3 hsa04380_Osteoclast_differentiation 20 128 6.404e-30 3.842e-28
4 hsa04662_B_cell_receptor_signaling_pathway 17 75 2.005e-28 9.021e-27
5 hsa04722_Neurotrophin_signaling_pathway 19 127 4.975e-28 1.791e-26
6 hsa04660_T_cell_receptor_signaling_pathway 18 108 1.862e-27 5.586e-26
7 hsa04910_Insulin_signaling_pathway 16 138 9.207e-22 2.368e-20
8 hsa04010_MAPK_signaling_pathway 19 268 1.184e-21 2.664e-20
9 hsa04062_Chemokine_signaling_pathway 17 189 3.611e-21 7.222e-20
10 hsa04370_VEGF_signaling_pathway 13 76 4.122e-20 7.419e-19
11 hsa04014_Ras_signaling_pathway 17 236 1.668e-19 2.729e-18
12 hsa04650_Natural_killer_cell_mediated_cytotoxicity 14 136 2.336e-18 3.504e-17
13 hsa04151_PI3K_AKT_signaling_pathway 18 351 5.441e-18 7.533e-17
14 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 1.979e-17 2.544e-16
15 hsa04973_Carbohydrate_digestion_and_absorption 9 44 5.845e-15 7.014e-14
16 hsa04150_mTOR_signaling_pathway 9 52 2.979e-14 3.352e-13
17 hsa04510_Focal_adhesion 12 200 5.325e-13 5.639e-12
18 hsa04622_RIG.I.like_receptor_signaling_pathway 9 71 5.778e-13 5.778e-12
19 hsa04630_Jak.STAT_signaling_pathway 11 155 8.603e-13 8.15e-12
20 hsa04664_Fc_epsilon_RI_signaling_pathway 9 79 1.568e-12 1.411e-11
21 hsa04012_ErbB_signaling_pathway 9 87 3.838e-12 3.29e-11
22 hsa04621_NOD.like_receptor_signaling_pathway 8 59 6.907e-12 5.651e-11
23 hsa04666_Fc_gamma_R.mediated_phagocytosis 9 95 8.635e-12 6.758e-11
24 hsa04920_Adipocytokine_signaling_pathway 8 68 2.256e-11 1.692e-10
25 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 3.35e-11 2.412e-10
26 hsa04115_p53_signaling_pathway 7 69 1.26e-09 8.72e-09
27 hsa04070_Phosphatidylinositol_signaling_system 7 78 3.022e-09 2.015e-08
28 hsa04623_Cytosolic_DNA.sensing_pathway 6 56 1.47e-08 9.45e-08
29 hsa04670_Leukocyte_transendothelial_migration 7 117 5.19e-08 3.221e-07
30 hsa04720_Long.term_potentiation 6 70 5.75e-08 3.45e-07
31 hsa04114_Oocyte_meiosis 6 114 1.058e-06 6.145e-06
32 hsa04810_Regulation_of_actin_cytoskeleton 7 214 3.098e-06 1.743e-05
33 hsa04310_Wnt_signaling_pathway 6 151 5.431e-06 2.963e-05
34 hsa04020_Calcium_signaling_pathway 6 177 1.348e-05 7.137e-05
35 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.0002963 0.001524
36 hsa04742_Taste_transduction 3 52 0.0004863 0.002431
37 hsa04340_Hedgehog_signaling_pathway 3 56 0.0006049 0.002943
38 hsa00562_Inositol_phosphate_metabolism 3 57 0.0006371 0.003018
39 hsa04976_Bile_secretion 3 71 0.001209 0.005578
40 hsa04971_Gastric_acid_secretion 3 74 0.001362 0.00613
41 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 168 0.001526 0.006699
42 hsa04640_Hematopoietic_cell_lineage 3 88 0.00224 0.009599
43 hsa04970_Salivary_secretion 3 89 0.002313 0.009683
44 hsa04540_Gap_junction 3 90 0.002388 0.009768
45 hsa04912_GnRH_signaling_pathway 3 101 0.003311 0.01295
46 hsa04916_Melanogenesis 3 101 0.003311 0.01295
47 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.00488 0.01869
48 hsa04360_Axon_guidance 3 130 0.006691 0.02509
49 hsa04530_Tight_junction 2 133 0.05873 0.2158
50 hsa04740_Olfactory_transduction 3 388 0.1067 0.3841

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 DGCR5 hsa-miR-107;hsa-miR-139-5p;hsa-miR-140-5p;hsa-miR-190a-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-362-3p;hsa-miR-375;hsa-miR-577 11 IL1RAP Sponge network 1.383 0.01835 1.199 0.00709 0.476
2

RFPL1S

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p 11 AKT3 Sponge network -0.223 0.70704 -0.749 0.06936 0.466
3

EMX2OS

 hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p;hsa-miR-577 12 AKT3 Sponge network -1.088 0.10042 -0.749 0.06936 0.354
4

MEG3

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-577;hsa-miR-616-5p 11 AKT3 Sponge network -1.645 0.00049 -0.749 0.06936 0.312
5

PCA3

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-144-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p 28 PIK3R1 Sponge network -2.778 8.0E-5 -1.094 2.0E-5 0.309
6

PCA3

 hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-200c-3p;hsa-miR-330-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 11 PRKACB Sponge network -2.778 8.0E-5 -2.003 0 0.257

Quest ID: 92da04e19a935d425ff168e4a4936ff7