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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ABCA1 0.28 0.12701 0.61 0.0002 mirMAP; miRNATAP -0.3 0 NA
2 hsa-let-7a-3p ABCA5 0.28 0.12701 -0.62 0.00028 mirMAP -0.15 0.00733 NA
3 hsa-let-7a-3p ABCC4 0.28 0.12701 0.37 0.06052 mirMAP -0.18 0.00536 NA
4 hsa-let-7a-3p ABCC9 0.28 0.12701 -0.47 0.14121 mirMAP -0.91 0 NA
5 hsa-let-7a-3p ABCD2 0.28 0.12701 -1.04 0.0005 mirMAP -0.45 0 NA
6 hsa-let-7a-3p ABI3BP 0.28 0.12701 -2.06 0 miRNATAP -0.91 0 NA
7 hsa-let-7a-3p ACAP2 0.28 0.12701 0.18 0.06624 MirTarget; mirMAP; miRNATAP -0.17 0 NA
8 hsa-let-7a-3p ACVR1 0.28 0.12701 0.28 0.00234 MirTarget; miRNATAP -0.11 0.00039 NA
9 hsa-let-7a-3p ACVR2B 0.28 0.12701 0.48 0.00365 MirTarget -0.19 0.00039 NA
10 hsa-let-7a-3p ADAM23 0.28 0.12701 -0.71 0.00863 mirMAP -0.5 0 NA
11 hsa-let-7a-3p ADAMTS5 0.28 0.12701 0.19 0.27716 mirMAP -0.33 0 NA
12 hsa-let-7a-3p ADAMTSL3 0.28 0.12701 -1.56 0 MirTarget -0.73 0 NA
13 hsa-let-7a-3p ADCYAP1 0.28 0.12701 -1.7 0.00038 miRNATAP -0.73 0 NA
14 hsa-let-7a-3p ADD2 0.28 0.12701 -0.33 0.34514 mirMAP -0.53 0 NA
15 hsa-let-7a-3p ADH5 0.28 0.12701 -0.37 0.00013 MirTarget -0.15 0 NA
16 hsa-let-7a-3p AFF3 0.28 0.12701 -2.37 0 MirTarget -0.64 0 NA
17 hsa-let-7a-3p AFF4 0.28 0.12701 -0.27 0.01565 MirTarget; mirMAP -0.24 0 NA
18 hsa-let-7a-3p AHDC1 0.28 0.12701 -0.37 0.00866 miRNATAP -0.2 1.0E-5 NA
19 hsa-let-7a-3p AKAP11 0.28 0.12701 0.2 0.09825 mirMAP -0.29 0 NA
20 hsa-let-7a-3p AKAP12 0.28 0.12701 -0.93 0.0028 miRNATAP -0.7 0 NA
21 hsa-let-7a-3p AKAP9 0.28 0.12701 0.25 0.08715 MirTarget -0.15 0.00208 NA
22 hsa-let-7a-3p AKTIP 0.28 0.12701 -0.38 0.00082 MirTarget -0.22 0 NA
23 hsa-let-7a-3p ALDH1L2 0.28 0.12701 0.23 0.32096 MirTarget -0.35 0 NA
24 hsa-let-7a-3p ALG10B 0.28 0.12701 -0.05 0.81184 MirTarget -0.16 0.02105 NA
25 hsa-let-7a-3p ALKBH8 0.28 0.12701 0.35 0.00043 MirTarget -0.14 4.0E-5 NA
26 hsa-let-7a-3p AMIGO2 0.28 0.12701 0.61 0.01903 MirTarget; mirMAP -0.27 0.00207 NA
27 hsa-let-7a-3p AMN1 0.28 0.12701 -0.3 0.02124 mirMAP -0.1 0.01681 NA
28 hsa-let-7a-3p AMOTL1 0.28 0.12701 -0.49 0.0546 mirMAP -0.63 0 NA
29 hsa-let-7a-3p AMOTL2 0.28 0.12701 0.15 0.30776 miRNATAP -0.11 0.02453 NA
30 hsa-let-7a-3p ANK3 0.28 0.12701 -0.55 0.00086 MirTarget -0.16 0.00316 NA
31 hsa-let-7a-3p ANKRD50 0.28 0.12701 0.27 0.04034 mirMAP -0.25 0 NA
32 hsa-let-7a-3p ANKS1B 0.28 0.12701 -0.22 0.12837 miRNATAP -0.28 0 NA
33 hsa-let-7a-3p ANO4 0.28 0.12701 0.11 0.76908 MirTarget; miRNATAP -0.29 0.01822 NA
34 hsa-let-7a-3p ANO5 0.28 0.12701 -2.17 0 mirMAP -0.76 0 NA
35 hsa-let-7a-3p ANTXR1 0.28 0.12701 0.82 0.00014 mirMAP; miRNATAP -0.42 0 NA
36 hsa-let-7a-3p APC 0.28 0.12701 -0.26 0.04051 mirMAP -0.25 0 NA
37 hsa-let-7a-3p APLF 0.28 0.12701 -0.24 0.12306 MirTarget -0.26 0 NA
38 hsa-let-7a-3p APPBP2 0.28 0.12701 -0.15 0.05098 mirMAP; miRNATAP -0.16 0 NA
39 hsa-let-7a-3p APPL1 0.28 0.12701 0.04 0.68234 MirTarget; mirMAP -0.13 7.0E-5 NA
40 hsa-let-7a-3p ARGLU1 0.28 0.12701 0.23 0.0598 mirMAP -0.13 0.00134 NA
41 hsa-let-7a-3p ARHGAP20 0.28 0.12701 -1.38 0 MirTarget; miRNATAP -0.69 0 NA
42 hsa-let-7a-3p ARHGAP28 0.28 0.12701 -0.91 0.00013 mirMAP -0.19 0.01861 NA
43 hsa-let-7a-3p ARHGAP29 0.28 0.12701 0.13 0.42953 mirMAP -0.31 0 NA
44 hsa-let-7a-3p ARHGAP5 0.28 0.12701 -0.12 0.26304 mirMAP -0.19 0 NA
45 hsa-let-7a-3p ARHGEF3 0.28 0.12701 0.02 0.82386 MirTarget -0.11 0.00239 NA
46 hsa-let-7a-3p ARHGEF33 0.28 0.12701 -0.33 0.12959 miRNATAP -0.46 0 NA
47 hsa-let-7a-3p ARID4A 0.28 0.12701 -0.05 0.68424 MirTarget; miRNATAP -0.27 0 NA
48 hsa-let-7a-3p ARID4B 0.28 0.12701 0.37 0.00063 MirTarget; miRNATAP -0.18 0 NA
49 hsa-let-7a-3p ARID5B 0.28 0.12701 0.34 0.01676 miRNATAP -0.23 0 NA
50 hsa-let-7a-3p ARIH1 0.28 0.12701 0.02 0.79347 MirTarget -0.17 0 NA
51 hsa-let-7a-3p ARL10 0.28 0.12701 -0.28 0.19832 mirMAP -0.46 0 NA
52 hsa-let-7a-3p ARMC8 0.28 0.12701 -0.11 0.17343 miRNAWalker2 validate -0.13 0 NA
53 hsa-let-7a-3p ARPP19 0.28 0.12701 0.11 0.27444 MirTarget -0.2 0 NA
54 hsa-let-7a-3p ARRDC3 0.28 0.12701 -0.15 0.28741 MirTarget -0.29 0 NA
55 hsa-let-7a-3p ARSB 0.28 0.12701 0.33 0.02033 mirMAP -0.31 0 NA
56 hsa-let-7a-3p ART4 0.28 0.12701 -0.77 0.0772 mirMAP -0.46 0.00143 NA
57 hsa-let-7a-3p ASAP1 0.28 0.12701 0.66 0 mirMAP -0.23 0 NA
58 hsa-let-7a-3p ASTN2 0.28 0.12701 -0.7 0.00014 mirMAP -0.19 0.00191 NA
59 hsa-let-7a-3p ATE1 0.28 0.12701 0.13 0.35236 mirMAP -0.11 0.01096 NA
60 hsa-let-7a-3p ATF2 0.28 0.12701 0.01 0.93568 MirTarget; mirMAP; miRNATAP -0.16 0 NA
61 hsa-let-7a-3p ATG14 0.28 0.12701 0 0.96836 mirMAP -0.27 0 NA
62 hsa-let-7a-3p ATG2B 0.28 0.12701 -0.11 0.28452 MirTarget -0.2 0 NA
63 hsa-let-7a-3p ATL2 0.28 0.12701 -0.38 0.00058 MirTarget -0.25 0 NA
64 hsa-let-7a-3p ATRX 0.28 0.12701 0.26 0.04408 MirTarget; miRNATAP -0.32 0 NA
65 hsa-let-7a-3p AUTS2 0.28 0.12701 -0.27 0.18068 miRNATAP -0.26 7.0E-5 NA
66 hsa-let-7a-3p AXIN2 0.28 0.12701 0.01 0.97155 miRNATAP -0.21 0.02551 NA
67 hsa-let-7a-3p B3GALNT1 0.28 0.12701 0.08 0.70688 mirMAP -0.15 0.02646 NA
68 hsa-let-7a-3p BACH1 0.28 0.12701 -0.04 0.68833 MirTarget; mirMAP -0.11 0.00162 NA
69 hsa-let-7a-3p BCAP29 0.28 0.12701 -0.09 0.29187 MirTarget; mirMAP -0.16 0 NA
70 hsa-let-7a-3p BCL11A 0.28 0.12701 -0.93 0.0063 mirMAP -0.33 0.00333 NA
71 hsa-let-7a-3p BCL6 0.28 0.12701 -0.21 0.19489 miRNATAP -0.34 0 NA
72 hsa-let-7a-3p BCLAF1 0.28 0.12701 0.21 0.00684 mirMAP -0.11 1.0E-5 NA
73 hsa-let-7a-3p BDP1 0.28 0.12701 0.41 0.00065 MirTarget; mirMAP -0.27 0 NA
74 hsa-let-7a-3p BEND6 0.28 0.12701 0.03 0.91694 mirMAP -0.47 0 NA
75 hsa-let-7a-3p BICD2 0.28 0.12701 -0.02 0.88611 mirMAP -0.27 0 NA
76 hsa-let-7a-3p BMP2K 0.28 0.12701 0.25 0.01328 mirMAP -0.1 0.00148 NA
77 hsa-let-7a-3p BMP3 0.28 0.12701 -2.36 0.00035 MirTarget; mirMAP -1.5 0 NA
78 hsa-let-7a-3p BMPER 0.28 0.12701 -2.32 0 MirTarget -0.67 0 NA
79 hsa-let-7a-3p BMPR1B 0.28 0.12701 -1.24 0.00562 miRNATAP -0.66 1.0E-5 NA
80 hsa-let-7a-3p BMPR2 0.28 0.12701 0.21 0.0635 MirTarget; miRNATAP -0.28 0 NA
81 hsa-let-7a-3p BNC2 0.28 0.12701 -0.49 0.09988 mirMAP -0.77 0 NA
82 hsa-let-7a-3p BNIP2 0.28 0.12701 -0.05 0.63907 mirMAP -0.29 0 NA
83 hsa-let-7a-3p BOD1L1 0.28 0.12701 0.23 0.03726 MirTarget -0.24 0 NA
84 hsa-let-7a-3p BRWD1 0.28 0.12701 0.05 0.6598 mirMAP -0.2 0 NA
85 hsa-let-7a-3p BTAF1 0.28 0.12701 0.28 0.01596 MirTarget; miRNATAP -0.19 0 NA
86 hsa-let-7a-3p BTBD7 0.28 0.12701 -0.17 0.03473 mirMAP; miRNATAP -0.12 1.0E-5 NA
87 hsa-let-7a-3p BTC 0.28 0.12701 -1.69 0 mirMAP -0.43 1.0E-5 NA
88 hsa-let-7a-3p BTF3L4 0.28 0.12701 0.18 0.05058 MirTarget; miRNATAP -0.15 0 NA
89 hsa-let-7a-3p BTNL9 0.28 0.12701 0.41 0.12761 MirTarget -0.27 0.00215 NA
90 hsa-let-7a-3p BVES 0.28 0.12701 -1.51 1.0E-5 mirMAP -0.95 0 NA
91 hsa-let-7a-3p C16orf52 0.28 0.12701 -0.07 0.3851 mirMAP; miRNATAP -0.18 0 NA
92 hsa-let-7a-3p C4orf3 0.28 0.12701 -0.9 0 mirMAP -0.16 5.0E-5 NA
93 hsa-let-7a-3p C4orf32 0.28 0.12701 -0.55 4.0E-5 mirMAP -0.11 0.01525 NA
94 hsa-let-7a-3p C8orf46 0.28 0.12701 -1.93 2.0E-5 mirMAP -0.98 0 NA
95 hsa-let-7a-3p CACNA1C 0.28 0.12701 -0.18 0.557 MirTarget -0.79 0 NA
96 hsa-let-7a-3p CACNA2D1 0.28 0.12701 -0.85 0.00675 mirMAP -0.68 0 NA
97 hsa-let-7a-3p CACNB2 0.28 0.12701 -1.06 0.00045 MirTarget; mirMAP -0.9 0 NA
98 hsa-let-7a-3p CACNG4 0.28 0.12701 -0.7 0.19815 MirTarget -0.49 0.00654 NA
99 hsa-let-7a-3p CAMSAP1 0.28 0.12701 0.24 0.03991 mirMAP -0.15 0.00012 NA
100 hsa-let-7a-3p CAPZA2 0.28 0.12701 -0.19 0.08777 MirTarget -0.15 6.0E-5 NA
101 hsa-let-7a-3p CASD1 0.28 0.12701 -0.06 0.67432 MirTarget; miRNATAP -0.26 0 NA
102 hsa-let-7a-3p CASP8AP2 0.28 0.12701 0.47 0.00018 MirTarget -0.25 0 NA
103 hsa-let-7a-3p CBL 0.28 0.12701 0.29 0.01267 MirTarget -0.19 0 NA
104 hsa-let-7a-3p CBLN4 0.28 0.12701 0.52 0.26155 MirTarget -0.78 0 NA
105 hsa-let-7a-3p CBX5 0.28 0.12701 0.16 0.24446 mirMAP -0.16 0.00065 NA
106 hsa-let-7a-3p CCDC102B 0.28 0.12701 0.32 0.04327 MirTarget -0.17 0.00131 NA
107 hsa-let-7a-3p CCDC141 0.28 0.12701 -0 0.99219 mirMAP -0.34 0.00055 NA
108 hsa-let-7a-3p CCDC50 0.28 0.12701 -0.21 0.09064 miRNATAP -0.34 0 NA
109 hsa-let-7a-3p CCND2 0.28 0.12701 -0.27 0.3112 mirMAP -0.37 2.0E-5 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
110 hsa-let-7a-3p CCNG2 0.28 0.12701 -0.15 0.25163 MirTarget; mirMAP -0.12 0.00497 NA
111 hsa-let-7a-3p CCPG1 0.28 0.12701 -0.21 0.04535 mirMAP -0.13 0.00013 NA
112 hsa-let-7a-3p CD109 0.28 0.12701 0.26 0.3195 mirMAP -0.51 0 NA
113 hsa-let-7a-3p CD44 0.28 0.12701 0.22 0.30295 miRNATAP -0.19 0.00876 NA
114 hsa-let-7a-3p CDC42EP3 0.28 0.12701 -0.12 0.56698 MirTarget; mirMAP -0.47 0 NA
115 hsa-let-7a-3p CDC73 0.28 0.12701 0.09 0.20463 mirMAP; miRNATAP -0.1 1.0E-5 NA
116 hsa-let-7a-3p CDHR3 0.28 0.12701 -0.98 4.0E-5 mirMAP -0.4 0 NA
117 hsa-let-7a-3p CDK17 0.28 0.12701 0.07 0.48708 MirTarget; miRNATAP -0.26 0 NA
118 hsa-let-7a-3p CDK19 0.28 0.12701 0.33 0.00181 MirTarget; miRNATAP -0.11 0.00141 NA
119 hsa-let-7a-3p CDS2 0.28 0.12701 -0.26 0.01248 mirMAP -0.26 0 NA
120 hsa-let-7a-3p CELF2 0.28 0.12701 -1.1 1.0E-5 miRNATAP -0.56 0 NA
121 hsa-let-7a-3p CEP192 0.28 0.12701 0.5 2.0E-5 MirTarget -0.11 0.00483 NA
122 hsa-let-7a-3p CFL2 0.28 0.12701 -1.3 0 mirMAP -0.78 0 NA
123 hsa-let-7a-3p CGGBP1 0.28 0.12701 -0.06 0.38556 mirMAP -0.15 0 NA
124 hsa-let-7a-3p CHD1 0.28 0.12701 0.32 0.00215 MirTarget -0.17 0 NA
125 hsa-let-7a-3p CHD9 0.28 0.12701 -0.26 0.02092 mirMAP; miRNATAP -0.22 0 NA
126 hsa-let-7a-3p CHL1 0.28 0.12701 -1.95 0 MirTarget; miRNATAP -0.47 4.0E-5 NA
127 hsa-let-7a-3p CHM 0.28 0.12701 0.11 0.24003 MirTarget -0.16 0 NA
128 hsa-let-7a-3p CHMP1B 0.28 0.12701 -0.71 0 mirMAP -0.14 0.0001 NA
129 hsa-let-7a-3p CLASP2 0.28 0.12701 -0.04 0.71 MirTarget; miRNATAP -0.25 0 NA
130 hsa-let-7a-3p CLIC4 0.28 0.12701 -0.39 0.04124 MirTarget -0.57 0 NA
131 hsa-let-7a-3p CLIP1 0.28 0.12701 -0.22 0.08684 miRNATAP -0.37 0 NA
132 hsa-let-7a-3p CLK4 0.28 0.12701 -0.08 0.49185 mirMAP -0.22 0 NA
133 hsa-let-7a-3p CLOCK 0.28 0.12701 -0.1 0.34735 MirTarget -0.12 0.001 NA
134 hsa-let-7a-3p CNKSR2 0.28 0.12701 -1.85 0.00014 MirTarget; mirMAP; miRNATAP -1.14 0 NA
135 hsa-let-7a-3p CNKSR3 0.28 0.12701 -0.14 0.34161 MirTarget -0.2 1.0E-5 NA
136 hsa-let-7a-3p CNR1 0.28 0.12701 -2.22 1.0E-5 mirMAP -0.86 0 NA
137 hsa-let-7a-3p CNTN1 0.28 0.12701 -2.59 0 MirTarget; miRNATAP -1.15 0 NA
138 hsa-let-7a-3p CNTN5 0.28 0.12701 -0.22 0.61957 MirTarget; mirMAP -0.36 0.01296 NA
139 hsa-let-7a-3p CNTNAP3B 0.28 0.12701 -1.04 0.01401 mirMAP -0.82 0 NA
140 hsa-let-7a-3p COL12A1 0.28 0.12701 1.85 0 miRNATAP -0.32 0.00013 NA
141 hsa-let-7a-3p COL15A1 0.28 0.12701 0.68 0.00158 MirTarget -0.29 5.0E-5 NA
142 hsa-let-7a-3p COL4A1 0.28 0.12701 1.79 0 miRNATAP -0.26 0.00016 NA
143 hsa-let-7a-3p COL4A3BP 0.28 0.12701 -0.44 0 MirTarget; mirMAP; miRNATAP -0.16 0 NA
144 hsa-let-7a-3p COL4A4 0.28 0.12701 0.2 0.56272 mirMAP -0.38 0.00099 NA
145 hsa-let-7a-3p CORO1C 0.28 0.12701 -0.06 0.60556 MirTarget; miRNATAP -0.28 0 NA
146 hsa-let-7a-3p CPEB2 0.28 0.12701 -0.81 0 mirMAP; miRNATAP -0.24 0 NA
147 hsa-let-7a-3p CPEB3 0.28 0.12701 -0.73 0 MirTarget; miRNATAP -0.19 0 NA
148 hsa-let-7a-3p CPEB4 0.28 0.12701 -0.8 0 mirMAP; miRNATAP -0.19 0 NA
149 hsa-let-7a-3p CREBBP 0.28 0.12701 0.13 0.15186 miRNATAP -0.13 1.0E-5 NA
150 hsa-let-7a-3p CREBL2 0.28 0.12701 -0.29 0.00289 mirMAP -0.18 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 144 1672 2.516e-17 1.171e-13
2 NEUROGENESIS 122 1402 5.019e-15 1.168e-11
3 REGULATION OF CELL DEVELOPMENT 82 836 5.31e-13 8.236e-10
4 REGULATION OF CELL DIFFERENTIATION 121 1492 9.526e-13 9.244e-10
5 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 93 1021 9.933e-13 9.244e-10
6 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 136 1784 2.863e-12 2.22e-09
7 CELL DEVELOPMENT 114 1426 1.2e-11 7.978e-09
8 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 73 750 1.577e-11 8.071e-09
9 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 69 689 1.636e-11 8.071e-09
10 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 89 1008 1.735e-11 8.071e-09
11 CARDIOVASCULAR SYSTEM DEVELOPMENT 75 788 2.388e-11 9.258e-09
12 CIRCULATORY SYSTEM DEVELOPMENT 75 788 2.388e-11 9.258e-09
13 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 96 1142 4.09e-11 1.464e-08
14 PROTEIN PHOSPHORYLATION 84 944 4.566e-11 1.518e-08
15 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 125 1656 4.952e-11 1.536e-08
16 REGULATION OF PROTEIN MODIFICATION PROCESS 127 1710 9.814e-11 2.854e-08
17 REGULATION OF CELLULAR COMPONENT BIOGENESIS 72 767 1.15e-10 3.147e-08
18 NEGATIVE REGULATION OF CELL COMMUNICATION 96 1192 4.176e-10 1.079e-07
19 REGULATION OF PHOSPHORUS METABOLIC PROCESS 119 1618 7.665e-10 1.877e-07
20 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 113 1517 1.059e-09 2.371e-07
21 INTRACELLULAR SIGNAL TRANSDUCTION 116 1572 1.07e-09 2.371e-07
22 GROWTH 46 410 1.248e-09 2.639e-07
23 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 52 498 1.335e-09 2.7e-07
24 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 128 1805 1.579e-09 3.062e-07
25 CELLULAR COMPONENT MORPHOGENESIS 77 900 1.871e-09 3.482e-07
26 CELL PROJECTION ORGANIZATION 77 902 2.066e-09 3.697e-07
27 NEGATIVE REGULATION OF GENE EXPRESSION 110 1493 3.365e-09 5.399e-07
28 POSITIVE REGULATION OF GENE EXPRESSION 123 1733 3.321e-09 5.399e-07
29 HEART DEVELOPMENT 49 466 3.198e-09 5.399e-07
30 POSITIVE REGULATION OF MOLECULAR FUNCTION 126 1791 3.527e-09 5.47e-07
31 NEURON PROJECTION DEVELOPMENT 54 545 4.153e-09 6.234e-07
32 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 82 1004 4.684e-09 6.811e-07
33 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 102 1360 5.373e-09 7.576e-07
34 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 103 1395 1.018e-08 1.393e-06
35 REGULATION OF HYDROLASE ACTIVITY 99 1327 1.212e-08 1.525e-06
36 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 29 207 1.162e-08 1.525e-06
37 REGULATION OF GTPASE ACTIVITY 61 673 1.212e-08 1.525e-06
38 CENTRAL NERVOUS SYSTEM DEVELOPMENT 73 872 1.262e-08 1.545e-06
39 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 96 1275 1.316e-08 1.57e-06
40 SINGLE ORGANISM BEHAVIOR 42 384 1.391e-08 1.578e-06
41 NEURON DIFFERENTIATION 73 874 1.387e-08 1.578e-06
42 HEAD DEVELOPMENT 63 709 1.472e-08 1.631e-06
43 TISSUE DEVELOPMENT 109 1518 1.616e-08 1.748e-06
44 PHOSPHORYLATION 93 1228 1.721e-08 1.82e-06
45 DEVELOPMENTAL GROWTH 38 333 2.199e-08 2.274e-06
46 REGULATION OF CELL DEATH 106 1472 2.256e-08 2.282e-06
47 REGULATION OF CELL PROJECTION ORGANIZATION 53 558 2.432e-08 2.407e-06
48 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 77 957 2.705e-08 2.517e-06
49 POSITIVE REGULATION OF CELL COMMUNICATION 109 1532 2.628e-08 2.517e-06
50 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 50 513 2.685e-08 2.517e-06
51 REGULATION OF CELLULAR COMPONENT MOVEMENT 66 771 2.805e-08 2.559e-06
52 RESPONSE TO ENDOGENOUS STIMULUS 104 1450 3.816e-08 3.415e-06
53 REGULATION OF NEURON DIFFERENTIATION 52 554 4.863e-08 4.269e-06
54 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 124 1848 7.354e-08 6.222e-06
55 NEGATIVE REGULATION OF PHOSPHORYLATION 43 422 7.349e-08 6.222e-06
56 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 80 1036 8.316e-08 6.789e-06
57 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 80 1036 8.316e-08 6.789e-06
58 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 8 16 8.688e-08 6.97e-06
59 REGULATION OF CELL MORPHOGENESIS 51 552 1.081e-07 8.524e-06
60 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 86 1152 1.175e-07 8.839e-06
61 RESPONSE TO GROWTH FACTOR 46 475 1.176e-07 8.839e-06
62 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 66 801 1.178e-07 8.839e-06
63 UROGENITAL SYSTEM DEVELOPMENT 34 299 1.317e-07 9.724e-06
64 ORGAN MORPHOGENESIS 68 841 1.531e-07 1.113e-05
65 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 104 1492 1.579e-07 1.13e-05
66 REGULATION OF MAPK CASCADE 57 660 1.909e-07 1.346e-05
67 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 43 437 1.962e-07 1.362e-05
68 BEHAVIOR 48 516 2.099e-07 1.436e-05
69 INOSITOL LIPID MEDIATED SIGNALING 20 124 2.132e-07 1.438e-05
70 BLOOD VESSEL MORPHOGENESIS 38 364 2.281e-07 1.516e-05
71 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 84 1135 2.41e-07 1.579e-05
72 POSITIVE REGULATION OF CELL DEVELOPMENT 45 472 2.526e-07 1.632e-05
73 POSITIVE REGULATION OF CELL DIFFERENTIATION 66 823 3.161e-07 2.015e-05
74 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 49 541 3.493e-07 2.167e-05
75 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 49 541 3.493e-07 2.167e-05
76 POSITIVE REGULATION OF CATALYTIC ACTIVITY 104 1518 3.631e-07 2.223e-05
77 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 40 404 4.453e-07 2.691e-05
78 VASCULATURE DEVELOPMENT 44 469 5.354e-07 3.194e-05
79 REGULATION OF NEURON PROJECTION DEVELOPMENT 40 408 5.745e-07 3.384e-05
80 CELL PART MORPHOGENESIS 54 633 5.927e-07 3.447e-05
81 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 121 6.541e-07 3.757e-05
82 EMBRYO DEVELOPMENT 69 894 6.915e-07 3.924e-05
83 NEURON DEVELOPMENT 57 687 7.065e-07 3.961e-05
84 WNT SIGNALING PATHWAY 36 351 7.246e-07 4.014e-05
85 POSITIVE REGULATION OF RESPONSE TO STIMULUS 124 1929 7.431e-07 4.039e-05
86 REGULATION OF ADHERENS JUNCTION ORGANIZATION 12 50 7.465e-07 4.039e-05
87 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 60 740 7.713e-07 4.125e-05
88 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 10 34 8.203e-07 4.338e-05
89 REGULATION OF GLUCOSE IMPORT 13 60 9.178e-07 4.799e-05
90 NEGATIVE REGULATION OF CELL DIFFERENTIATION 52 609 9.35e-07 4.834e-05
91 NEURON PROJECTION MORPHOGENESIS 39 402 1.033e-06 5.283e-05
92 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 63 799 1.052e-06 5.323e-05
93 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 17 102 1.07e-06 5.355e-05
94 PROTEIN UBIQUITINATION 53 629 1.098e-06 5.437e-05
95 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 20 138 1.24e-06 6.073e-05
96 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 27 229 1.262e-06 6.116e-05
97 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 52 616 1.315e-06 6.308e-05
98 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 73 983 1.371e-06 6.512e-05
99 CELLULAR RESPONSE TO HORMONE STIMULUS 48 552 1.478e-06 6.875e-05
100 TUBE DEVELOPMENT 48 552 1.478e-06 6.875e-05
101 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 32 303 1.584e-06 7.238e-05
102 REGULATION OF OSSIFICATION 23 178 1.587e-06 7.238e-05
103 SENSORY ORGAN DEVELOPMENT 44 493 2.05e-06 9.259e-05
104 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 78 1087 2.184e-06 9.772e-05
105 NEGATIVE REGULATION OF CELL DEATH 66 872 2.377e-06 0.0001053
106 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 66 873 2.47e-06 0.0001084
107 CYTOSKELETON ORGANIZATION 64 838 2.524e-06 0.0001098
108 LOCOMOTION 79 1114 2.925e-06 0.000126
109 REGULATION OF CYTOSKELETON ORGANIZATION 44 502 3.29e-06 0.0001392
110 REGULATION OF BMP SIGNALING PATHWAY 14 77 3.276e-06 0.0001392
111 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 16 99 3.353e-06 0.0001393
112 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 16 99 3.353e-06 0.0001393
113 REGULATION OF KINASE ACTIVITY 60 776 3.563e-06 0.0001455
114 REGULATION OF EPITHELIAL CELL PROLIFERATION 30 285 3.565e-06 0.0001455
115 REGULATION OF ORGAN MORPHOGENESIS 27 242 3.657e-06 0.000148
116 EMBRYONIC MORPHOGENESIS 46 539 4.032e-06 0.0001617
117 REGULATION OF CELL JUNCTION ASSEMBLY 13 68 4.09e-06 0.0001627
118 REGULATION OF CELL MATRIX ADHESION 15 90 4.562e-06 0.0001794
119 REGULATION OF STEM CELL DIFFERENTIATION 17 113 4.587e-06 0.0001794
120 POSITIVE REGULATION OF NEURON DIFFERENTIATION 31 306 5.446e-06 0.0002112
121 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 35 368 5.708e-06 0.0002195
122 TUBE MORPHOGENESIS 32 323 6.16e-06 0.0002349
123 ACTIVATION OF PROTEIN KINASE ACTIVITY 29 279 6.606e-06 0.0002499
124 TISSUE MORPHOGENESIS 45 533 6.775e-06 0.0002528
125 POSITIVE REGULATION OF GLUCOSE TRANSPORT 10 42 6.792e-06 0.0002528
126 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 122 1977 6.985e-06 0.000258
127 REGULATION OF WNT SIGNALING PATHWAY 31 310 7.096e-06 0.00026
128 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 39 437 7.766e-06 0.0002823
129 SKELETAL SYSTEM DEVELOPMENT 40 455 8.519e-06 0.0003073
130 EPITHELIUM DEVELOPMENT 68 945 9.192e-06 0.000329
131 REGULATION OF TRANSFERASE ACTIVITY 68 946 9.517e-06 0.000338
132 REGULATION OF CELL PROLIFERATION 97 1496 9.785e-06 0.0003449
133 HIPPO SIGNALING 8 27 9.939e-06 0.0003477
134 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 7 20 1.054e-05 0.0003658
135 REGULATION OF DEVELOPMENTAL GROWTH 29 289 1.302e-05 0.0004486
136 MORPHOGENESIS OF AN EPITHELIUM 36 400 1.436e-05 0.0004876
137 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 11 55 1.43e-05 0.0004876
138 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 32 337 1.469e-05 0.0004918
139 MULTICELLULAR ORGANISMAL SIGNALING 17 123 1.461e-05 0.0004918
140 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 25 232 1.52e-05 0.000498
141 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 55 724 1.509e-05 0.000498
142 LIPID PHOSPHORYLATION 15 99 1.512e-05 0.000498
143 POSITIVE REGULATION OF HYDROLASE ACTIVITY 65 905 1.543e-05 0.000502
144 OVULATION CYCLE PROCESS 14 88 1.638e-05 0.0005292
145 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 40 470 1.817e-05 0.0005829
146 REGULATION OF SYNAPSE ORGANIZATION 16 113 1.905e-05 0.0006071
147 EYE DEVELOPMENT 31 326 1.934e-05 0.0006123
148 CELLULAR RESPONSE TO NITROGEN COMPOUND 42 505 1.956e-05 0.000615
149 NEGATIVE REGULATION OF CELL PROLIFERATION 50 643 2.005e-05 0.0006261
150 REGULATION OF MEMBRANE POTENTIAL 32 343 2.092e-05 0.000649
151 REGULATION OF EPITHELIAL CELL MIGRATION 20 166 2.138e-05 0.0006589
152 RHYTHMIC PROCESS 29 298 2.319e-05 0.0007099
153 AMEBOIDAL TYPE CELL MIGRATION 19 154 2.441e-05 0.0007414
154 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 15 103 2.454e-05 0.0007414
155 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 9 39 2.578e-05 0.0007738
156 APPENDAGE DEVELOPMENT 20 169 2.78e-05 0.0008239
157 LIMB DEVELOPMENT 20 169 2.78e-05 0.0008239
158 BONE DEVELOPMENT 19 156 2.929e-05 0.0008624
159 POSITIVE REGULATION OF KINASE ACTIVITY 40 482 3.224e-05 0.0009436
160 ACTION POTENTIAL 14 94 3.519e-05 0.001023
161 SYNAPSE ORGANIZATION 18 145 3.648e-05 0.001054
162 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 62 876 3.753e-05 0.001078
163 REGULATION OF CELL SUBSTRATE ADHESION 20 173 3.902e-05 0.001114
164 POSITIVE REGULATION OF LOCOMOTION 36 420 4.061e-05 0.001145
165 ENDOTHELIAL CELL DIFFERENTIATION 12 72 4.057e-05 0.001145
166 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 6 17 4.392e-05 0.001219
167 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 24 232 4.356e-05 0.001219
168 POSITIVE REGULATION OF OSSIFICATION 13 84 4.403e-05 0.001219
169 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 17 134 4.507e-05 0.001241
170 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 35 406 4.604e-05 0.001258
171 REGULATION OF SYSTEM PROCESS 41 507 4.646e-05 0.001258
172 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 62 4.651e-05 0.001258
173 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 9 42 4.846e-05 0.001303
174 ADULT BEHAVIOR 17 135 4.959e-05 0.001315
175 PALATE DEVELOPMENT 13 85 5.002e-05 0.001315
176 MESENCHYME DEVELOPMENT 21 190 4.93e-05 0.001315
177 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 51 684 4.996e-05 0.001315
178 NEGATIVE REGULATION OF TRANSPORT 38 458 5.071e-05 0.001325
179 REGULATION OF TRANSPORT 109 1804 5.526e-05 0.001437
180 PROTEIN LOCALIZATION 109 1805 5.652e-05 0.001461
181 REGULATION OF OSTEOBLAST DIFFERENTIATION 15 112 6.655e-05 0.001711
182 TRANSMISSION OF NERVE IMPULSE 10 54 7.012e-05 0.001793
183 REGULATION OF GLUCOSE TRANSPORT 14 100 7.076e-05 0.001793
184 MODULATION OF SYNAPTIC TRANSMISSION 28 301 7.092e-05 0.001793
185 PEPTIDYL AMINO ACID MODIFICATION 59 841 7.388e-05 0.001858
186 REGULATION OF MAP KINASE ACTIVITY 29 319 7.996e-05 0.002
187 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 31 352 8.317e-05 0.00207
188 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 11 66 8.441e-05 0.002078
189 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 66 8.441e-05 0.002078
190 HEART MORPHOGENESIS 22 212 8.534e-05 0.00209
191 POSITIVE REGULATION OF MAPK CASCADE 38 470 8.757e-05 0.002133
192 TELENCEPHALON DEVELOPMENT 23 228 9.178e-05 0.002224
193 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 11 67 9.722e-05 0.002308
194 REGULATION OF DENDRITIC SPINE DEVELOPMENT 10 56 9.674e-05 0.002308
195 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 11 67 9.722e-05 0.002308
196 HEAD MORPHOGENESIS 8 36 9.698e-05 0.002308
197 NEGATIVE REGULATION OF MOLECULAR FUNCTION 71 1079 0.0001044 0.002465
198 CELLULAR RESPONSE TO LIPID 37 457 0.000105 0.002468
199 FOREBRAIN DEVELOPMENT 31 357 0.0001077 0.002519
200 PEPTIDYL TYROSINE MODIFICATION 20 186 0.0001084 0.002523
201 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 17 144 0.000112 0.002552
202 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 46 616 0.0001118 0.002552
203 ORGAN GROWTH 11 68 0.0001117 0.002552
204 ANGIOGENESIS 27 293 0.0001111 0.002552
205 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 22 216 0.0001124 0.002552
206 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 262 0.0001138 0.002565
207 REPRODUCTIVE SYSTEM DEVELOPMENT 34 408 0.0001141 0.002565
208 NEURONAL ACTION POTENTIAL 7 28 0.00012 0.002685
209 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 15 118 0.0001216 0.002694
210 CEREBRAL CORTEX DEVELOPMENT 14 105 0.0001211 0.002694
211 RESPONSE TO OXYGEN CONTAINING COMPOUND 86 1381 0.0001325 0.002922
212 POSITIVE REGULATION OF CATABOLIC PROCESS 33 395 0.0001365 0.002996
213 SEX DIFFERENTIATION 25 266 0.0001446 0.003159
214 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 22 220 0.0001469 0.003185
215 NEURON PROJECTION GUIDANCE 21 205 0.0001472 0.003185
216 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 23 236 0.0001542 0.003321
217 MICROTUBULE CYTOSKELETON ORGANIZATION 30 348 0.0001571 0.003369
218 MUSCLE STRUCTURE DEVELOPMENT 35 432 0.0001578 0.003369
219 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 6 21 0.0001668 0.003544
220 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 9 49 0.0001718 0.003633
221 CELLULAR MACROMOLECULE LOCALIZATION 78 1234 0.0001733 0.003648
222 SECRETION BY CELL 38 486 0.0001741 0.003649
223 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 10 60 0.0001761 0.003659
224 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 10 60 0.0001761 0.003659
225 PATTERN SPECIFICATION PROCESS 34 418 0.0001809 0.003741
226 NEGATIVE REGULATION OF CELL MATRIX ADHESION 7 30 0.0001918 0.00395
227 NEGATIVE REGULATION OF CELL DEVELOPMENT 27 303 0.0001931 0.003959
228 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 9 50 0.0002018 0.004101
229 FACE DEVELOPMENT 9 50 0.0002018 0.004101
230 MEMBRANE DEPOLARIZATION 10 61 0.0002029 0.004105
231 REGULATION OF GROWTH 46 633 0.0002082 0.004194
232 MORPHOGENESIS OF A BRANCHING STRUCTURE 18 167 0.0002284 0.004581
233 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 153 0.0002349 0.004672
234 PALLIUM DEVELOPMENT 17 153 0.0002349 0.004672
235 REGULATION OF MICROTUBULE BASED PROCESS 23 243 0.000237 0.004692
236 REGULATION OF TRANSPORTER ACTIVITY 20 198 0.0002529 0.004987
237 OVULATION CYCLE 14 113 0.0002661 0.005224
238 SERTOLI CELL DEVELOPMENT 5 15 0.0002682 0.005244
239 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 100 0.0002706 0.005269
240 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 11 75 0.0002735 0.005281
241 NEURAL CREST CELL DIFFERENTIATION 11 75 0.0002735 0.005281
242 REGULATION OF ENDOTHELIAL CELL MIGRATION 14 114 0.0002919 0.005612
243 DENDRITE MORPHOGENESIS 8 42 0.000303 0.005778
244 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 15 128 0.0003018 0.005778
245 REGULATION OF ORGANELLE ORGANIZATION 74 1178 0.0003059 0.005809
246 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 36 465 0.0003086 0.005813
247 SKELETAL SYSTEM MORPHOGENESIS 20 201 0.0003086 0.005813
248 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 9 53 0.0003191 0.005988
249 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 21 217 0.0003226 0.006028
250 RAS PROTEIN SIGNAL TRANSDUCTION 16 143 0.0003277 0.0061
251 FEMALE SEX DIFFERENTIATION 14 116 0.0003499 0.006487
252 MICROTUBULE BASED PROCESS 39 522 0.0003605 0.006639
253 RESPONSE TO HORMONE 59 893 0.000361 0.006639
254 ENDOTHELIUM DEVELOPMENT 12 90 0.0003636 0.006661
255 COGNITION 23 251 0.0003776 0.006863
256 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 16 0.0003767 0.006863
257 BODY MORPHOGENESIS 8 44 0.0004226 0.007621
258 MAINTENANCE OF CELL NUMBER 15 132 0.0004215 0.007621
259 REGULATION OF SYNAPSE ASSEMBLY 11 79 0.0004337 0.007761
260 BONE MORPHOGENESIS 11 79 0.0004337 0.007761
261 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 15 133 0.0004571 0.008149
262 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 43 602 0.000475 0.008437
263 SMAD PROTEIN SIGNAL TRANSDUCTION 9 56 0.0004878 0.008598
264 OUTFLOW TRACT MORPHOGENESIS 9 56 0.0004878 0.008598
265 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 19 193 0.0004933 0.008648
266 MESENCHYMAL CELL DIFFERENTIATION 15 134 0.0004953 0.008648
267 REGULATION OF DENDRITE DEVELOPMENT 14 120 0.0004962 0.008648
268 EPITHELIAL CELL DIFFERENTIATION 37 495 0.0005009 0.008696
269 REGULATION OF ENERGY HOMEOSTASIS 5 17 0.0005154 0.008883
270 REGULATION OF PROTEIN KINASE A SIGNALING 5 17 0.0005154 0.008883
271 POSITIVE REGULATION OF CELL DEATH 43 605 0.0005261 0.009033
272 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 14 121 0.00054 0.009238
273 LIPID MODIFICATION 20 210 0.0005443 0.009278
274 MUSCLE TISSUE DEVELOPMENT 24 275 0.0005781 0.009818
275 REGULATION OF CELL CYCLE 61 949 0.0005825 0.009856
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 101 1199 1.057e-11 9.824e-09
2 ENZYME BINDING 124 1737 1.996e-09 9.273e-07
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 59 629 6.1e-09 1.889e-06
4 PROTEIN KINASE ACTIVITY 59 640 1.15e-08 2.672e-06
5 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 17 81 3.266e-08 6.068e-06
6 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 43 420 6.419e-08 8.518e-06
7 MOLECULAR FUNCTION REGULATOR 98 1353 6.176e-08 8.518e-06
8 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 36 328 1.381e-07 1.603e-05
9 REGULATORY REGION NUCLEIC ACID BINDING 66 818 2.537e-07 2.619e-05
10 MACROMOLECULAR COMPLEX BINDING 97 1399 5.508e-07 5.117e-05
11 PROTEIN TYROSINE KINASE ACTIVITY 23 176 1.301e-06 9.695e-05
12 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 27 228 1.158e-06 9.695e-05
13 SEQUENCE SPECIFIC DNA BINDING 76 1037 1.357e-06 9.695e-05
14 KINASE ACTIVITY 65 842 1.462e-06 9.701e-05
15 ZINC ION BINDING 82 1155 1.793e-06 0.0001111
16 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 13 64 1.999e-06 0.0001161
17 GROWTH FACTOR BINDING 18 123 3.63e-06 0.0001984
18 CYTOKINE BINDING 15 92 6.038e-06 0.0002952
19 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 13 70 5.729e-06 0.0002952
20 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 70 992 1.299e-05 0.0006032
21 GTPASE BINDING 29 295 1.919e-05 0.000849
22 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 24 226 2.845e-05 0.001201
23 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 29 303 3.156e-05 0.001275
24 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 46 588 3.697e-05 0.001431
25 SMAD BINDING 12 72 4.057e-05 0.001462
26 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 17 133 4.091e-05 0.001462
27 TRANSCRIPTION COACTIVATOR BINDING 5 11 4.747e-05 0.001633
28 ENZYME REGULATOR ACTIVITY 66 959 4.958e-05 0.001645
29 PROTEIN SERINE THREONINE KINASE ACTIVITY 37 445 6.067e-05 0.001944
30 X1 PHOSPHATIDYLINOSITOL BINDING 6 19 8.96e-05 0.002775
31 UBIQUITIN LIKE PROTEIN LIGASE ACTIVITY 21 199 9.655e-05 0.002893
32 DOUBLE STRANDED DNA BINDING 54 764 0.0001229 0.003568
33 KINASE BINDING 45 606 0.0001503 0.004162
34 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 28 315 0.0001544 0.004162
35 TRANSCRIPTION COREPRESSOR ACTIVITY 22 221 0.0001568 0.004162
36 PROTEIN COMPLEX BINDING 62 935 0.0002332 0.005936
37 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 12 86 0.0002364 0.005936
38 PROTEIN KINASE A BINDING 8 42 0.000303 0.007166
39 INSULIN RECEPTOR BINDING 7 32 0.0002949 0.007166
40 MICROTUBULE BINDING 20 201 0.0003086 0.007166
41 TRANSITION METAL ION BINDING 85 1400 0.000331 0.007321
42 GROWTH FACTOR RECEPTOR BINDING 15 129 0.0003286 0.007321
43 CYTOSKELETAL PROTEIN BINDING 55 819 0.0003841 0.007503
44 RHO GTPASE BINDING 11 78 0.0003877 0.007503
45 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 43 0.0003587 0.007503
46 TRANSFORMING GROWTH FACTOR BETA BINDING 5 16 0.0003767 0.007503
47 TRANSCRIPTION COFACTOR BINDING 6 24 0.0003715 0.007503
48 CHROMATIN BINDING 34 435 0.0003776 0.007503
49 CORE PROMOTER PROXIMAL REGION DNA BINDING 30 371 0.0004679 0.008871
50 RAB GTPASE BINDING 14 120 0.0004962 0.00922
NumGOOverlapSizeP ValueAdj. P Value
1 SYNAPSE 61 754 6.704e-07 0.0003302
2 NEURON PROJECTION 71 942 1.131e-06 0.0003302
3 CELL PROJECTION 115 1786 1.845e-06 0.0003592
4 NEURON PART 87 1265 3.085e-06 0.0004504
5 SOMATODENDRITIC COMPARTMENT 51 650 1.301e-05 0.00152
6 POSTSYNAPSE 34 378 2.497e-05 0.002083
7 SYNAPSE PART 48 610 2.167e-05 0.002083
8 MICROTUBULE ORGANIZING CENTER 48 623 3.696e-05 0.002698
9 PML BODY 14 97 5.028e-05 0.003263
10 CELL PROJECTION PART 65 946 5.933e-05 0.003465
11 MICROTUBULE CYTOSKELETON 71 1068 7.632e-05 0.003887
12 EXCITATORY SYNAPSE 21 197 8.351e-05 0.003887
13 CYTOSKELETON 116 1967 8.652e-05 0.003887
14 TRANSFERASE COMPLEX 51 703 9.977e-05 0.004162
15 CENTROSOME 38 487 0.0001815 0.006759
16 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 0.0001852 0.006759
17 CELL JUNCTION 73 1151 0.000254 0.008727
18 APICAL JUNCTION COMPLEX 15 128 0.0003018 0.009791

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04350_TGF.beta_signaling_pathway 15 85 2.176e-06 0.0003917
2 hsa04510_Focal_adhesion 23 200 1.15e-05 0.001035
3 hsa04310_Wnt_signaling_pathway 19 151 1.844e-05 0.001098
4 hsa04390_Hippo_signaling_pathway 19 154 2.441e-05 0.001098
5 hsa04810_Regulation_of_actin_cytoskeleton 20 214 0.0006915 0.02186
6 hsa04520_Adherens_junction 10 73 0.0008904 0.02186
7 hsa04010_MAPK_signaling_pathway 23 268 0.0009364 0.02186
8 hsa04014_Ras_signaling_pathway 21 236 0.0009714 0.02186
9 hsa04151_PI3K_AKT_signaling_pathway 27 351 0.001824 0.03527
10 hsa04910_Insulin_signaling_pathway 14 138 0.001959 0.03527
11 hsa04144_Endocytosis 17 203 0.005254 0.08597
12 hsa04512_ECM.receptor_interaction 9 85 0.009072 0.1361
13 hsa04630_Jak.STAT_signaling_pathway 13 155 0.01344 0.1861
14 hsa04360_Axon_guidance 11 130 0.02064 0.2654
15 hsa04270_Vascular_smooth_muscle_contraction 10 116 0.02371 0.2845
16 hsa04720_Long.term_potentiation 7 70 0.02681 0.3016
17 hsa04120_Ubiquitin_mediated_proteolysis 11 139 0.03182 0.3369
18 hsa02010_ABC_transporters 5 44 0.03582 0.3582
19 hsa04140_Regulation_of_autophagy 4 34 0.05227 0.4952
20 hsa04514_Cell_adhesion_molecules_.CAMs. 10 136 0.05958 0.5209
21 hsa04920_Adipocytokine_signaling_pathway 6 68 0.06468 0.5209
22 hsa04150_mTOR_signaling_pathway 5 52 0.06555 0.5209
23 hsa04115_p53_signaling_pathway 6 69 0.06846 0.5209
24 hsa04710_Circadian_rhythm_._mammal 3 23 0.06945 0.5209
25 hsa04340_Hedgehog_signaling_pathway 5 56 0.08434 0.6073
26 hsa04916_Melanogenesis 7 101 0.1307 0.9046
27 hsa04012_ErbB_signaling_pathway 6 87 0.157 1
28 hsa04722_Neurotrophin_signaling_pathway 8 127 0.1634 1
29 hsa04110_Cell_cycle 8 128 0.1683 1
30 hsa00670_One_carbon_pool_by_folate 2 18 0.1725 1
31 hsa00531_Glycosaminoglycan_degradation 2 19 0.1878 1
32 hsa04260_Cardiac_muscle_contraction 5 77 0.2201 1
33 hsa04974_Protein_digestion_and_absorption 5 81 0.2512 1
34 hsa04977_Vitamin_digestion_and_absorption 2 24 0.2658 1
35 hsa03015_mRNA_surveillance_pathway 5 83 0.2672 1
36 hsa04540_Gap_junction 5 90 0.3245 1
37 hsa04730_Long.term_depression 4 70 0.3366 1
38 hsa00510_N.Glycan_biosynthesis 3 49 0.3373 1
39 hsa04114_Oocyte_meiosis 6 114 0.3429 1
40 hsa04666_Fc_gamma_R.mediated_phagocytosis 5 95 0.3663 1
41 hsa04062_Chemokine_signaling_pathway 9 189 0.3945 1
42 hsa04070_Phosphatidylinositol_signaling_system 4 78 0.4131 1
43 hsa00562_Inositol_phosphate_metabolism 3 57 0.4288 1
44 hsa04660_T_cell_receptor_signaling_pathway 5 108 0.474 1
45 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.5296 1
46 hsa04670_Leukocyte_transendothelial_migration 5 117 0.545 1
47 hsa03018_RNA_degradation 3 71 0.5754 1
48 hsa04330_Notch_signaling_pathway 2 47 0.591 1
49 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.6128 1
50 hsa04020_Calcium_signaling_pathway 7 177 0.6141 1
51 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.6479 1
52 hsa00230_Purine_metabolism 6 162 0.6764 1
53 hsa04914_Progesterone.mediated_oocyte_maturation 3 87 0.7111 1
54 hsa04640_Hematopoietic_cell_lineage 3 88 0.7184 1
55 hsa04210_Apoptosis 3 89 0.7255 1
56 hsa00830_Retinol_metabolism 2 64 0.7545 1
57 hsa04912_GnRH_signaling_pathway 3 101 0.8002 1
58 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 2 71 0.8034 1
59 hsa04976_Bile_secretion 2 71 0.8034 1
60 hsa04530_Tight_junction 4 133 0.8126 1
61 hsa04971_Gastric_acid_secretion 2 74 0.8216 1
62 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 0.826 1
63 hsa04370_VEGF_signaling_pathway 2 76 0.8329 1
64 hsa00564_Glycerophospholipid_metabolism 2 80 0.8535 1
65 hsa04142_Lysosome 3 121 0.8866 1
66 hsa04145_Phagosome 4 156 0.8961 1
67 hsa04380_Osteoclast_differentiation 3 128 0.9079 1
68 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 168 0.925 1
69 hsa03013_RNA_transport 3 152 0.9561 1
70 hsa04740_Olfactory_transduction 2 388 1 1

Quest ID: 95523953889140448e9278fd3cd46ef3