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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-495-3p ACVR1B -0.08 0.76348 0.35 0.04863 MirTarget -0.11 0.00028 NA
2 hsa-miR-495-3p ARID4A -0.08 0.76348 -0.76 0 mirMAP -0.1 6.0E-5 NA
3 hsa-miR-495-3p ASB7 -0.08 0.76348 0.19 0.06556 mirMAP -0.1 0 NA
4 hsa-miR-495-3p ASS1 -0.08 0.76348 -0.97 0.03164 mirMAP -0.16 0.04323 NA
5 hsa-miR-495-3p BARD1 -0.08 0.76348 -0.34 0.3961 mirMAP -0.14 0.04174 NA
6 hsa-miR-495-3p BBX -0.08 0.76348 -0.51 0.00131 mirMAP -0.13 0 NA
7 hsa-miR-495-3p BRWD3 -0.08 0.76348 0.22 0.35044 MirTarget -0.12 0.00228 NA
8 hsa-miR-495-3p C1orf21 -0.08 0.76348 -1.51 0 mirMAP -0.11 0.00549 NA
9 hsa-miR-495-3p CAMK2G -0.08 0.76348 -0.52 0.0078 MirTarget -0.13 8.0E-5 NA
10 hsa-miR-495-3p CCNT2 -0.08 0.76348 0.05 0.80346 MirTarget; mirMAP -0.11 0.00191 NA
11 hsa-miR-495-3p CLOCK -0.08 0.76348 -0.51 0.03689 MirTarget -0.12 0.0029 NA
12 hsa-miR-495-3p COBLL1 -0.08 0.76348 -0.74 0.01674 mirMAP -0.12 0.0275 NA
13 hsa-miR-495-3p DDX3Y -0.08 0.76348 1.41 0.22711 mirMAP -0.58 0.00415 NA
14 hsa-miR-495-3p DPP8 -0.08 0.76348 -0.52 0.02104 MirTarget -0.13 0.00067 NA
15 hsa-miR-495-3p EIF4E3 -0.08 0.76348 -1.31 0 mirMAP -0.16 7.0E-5 NA
16 hsa-miR-495-3p EPC2 -0.08 0.76348 -0.52 9.0E-5 MirTarget -0.1 1.0E-5 NA
17 hsa-miR-495-3p ESM1 -0.08 0.76348 4.69 0 MirTarget -0.22 0.00551 NA
18 hsa-miR-495-3p FMR1 -0.08 0.76348 0.2 0.13475 mirMAP -0.11 0 NA
19 hsa-miR-495-3p GATAD2B -0.08 0.76348 0.06 0.58994 mirMAP -0.1 0 NA
20 hsa-miR-495-3p GIGYF2 -0.08 0.76348 -0.6 0 mirMAP -0.12 0 NA
21 hsa-miR-495-3p GOLGA8B -0.08 0.76348 1.48 0.00014 mirMAP -0.15 0.02518 NA
22 hsa-miR-495-3p GPD2 -0.08 0.76348 0.54 0.00217 mirMAP -0.11 0.00041 NA
23 hsa-miR-495-3p HIPK3 -0.08 0.76348 -1.75 0 mirMAP -0.13 0.04538 NA
24 hsa-miR-495-3p IGF1R -0.08 0.76348 -0.49 0.0461 mirMAP -0.12 0.00445 NA
25 hsa-miR-495-3p KDM5D -0.08 0.76348 1.45 0.20778 MirTarget -0.64 0.00136 NA
26 hsa-miR-495-3p LCOR -0.08 0.76348 -0.36 0.27591 mirMAP -0.13 0.02856 NA
27 hsa-miR-495-3p LIMCH1 -0.08 0.76348 -1.22 0.00258 MirTarget -0.15 0.03858 NA
28 hsa-miR-495-3p LPP -0.08 0.76348 -2.04 0 mirMAP -0.18 9.0E-5 NA
29 hsa-miR-495-3p MBD5 -0.08 0.76348 -1.15 0 mirMAP -0.12 0.0001 NA
30 hsa-miR-495-3p MBLAC2 -0.08 0.76348 -0.34 0.07922 MirTarget -0.13 0.00017 NA
31 hsa-miR-495-3p MDM1 -0.08 0.76348 -0.21 0.27158 mirMAP -0.11 0.00117 NA
32 hsa-miR-495-3p MEGF9 -0.08 0.76348 -0.64 0.00228 mirMAP -0.11 0.00261 NA
33 hsa-miR-495-3p MID1 -0.08 0.76348 -0.18 0.49916 mirMAP -0.12 0.00933 NA
34 hsa-miR-495-3p MIPOL1 -0.08 0.76348 -0.47 0.07981 mirMAP -0.12 0.01089 NA
35 hsa-miR-495-3p MKNK2 -0.08 0.76348 -0.01 0.95974 MirTarget -0.1 0.00069 NA
36 hsa-miR-495-3p MOSPD2 -0.08 0.76348 -0.06 0.78626 MirTarget; mirMAP -0.11 0.00238 NA
37 hsa-miR-495-3p MYO9A -0.08 0.76348 -1.3 0 mirMAP -0.11 0.02228 NA
38 hsa-miR-495-3p NCKAP5 -0.08 0.76348 -0.57 0.21529 mirMAP -0.2 0.01288 NA
39 hsa-miR-495-3p NFIA -0.08 0.76348 -2.1 0 MirTarget -0.12 0.01204 NA
40 hsa-miR-495-3p NLGN4Y -0.08 0.76348 0.11 0.90515 mirMAP -0.42 0.00658 NA
41 hsa-miR-495-3p OCRL -0.08 0.76348 -0.47 0.00073 MirTarget -0.12 0 NA
42 hsa-miR-495-3p PARP16 -0.08 0.76348 0.15 0.24563 MirTarget -0.1 0 NA
43 hsa-miR-495-3p PHC3 -0.08 0.76348 -0.45 0.00181 MirTarget -0.1 3.0E-5 NA
44 hsa-miR-495-3p PHLDB2 -0.08 0.76348 -1.17 0.00022 mirMAP -0.11 0.04317 NA
45 hsa-miR-495-3p PPP1R12A -0.08 0.76348 -1.34 0 mirMAP -0.11 0.00018 NA
46 hsa-miR-495-3p PPP2R2B -0.08 0.76348 -2.25 0.00018 mirMAP -0.21 0.04213 NA
47 hsa-miR-495-3p PRKCA -0.08 0.76348 -1.04 0.00033 mirMAP -0.12 0.01613 NA
48 hsa-miR-495-3p PUM2 -0.08 0.76348 -0.05 0.65316 MirTarget; mirMAP -0.1 0 NA
49 hsa-miR-495-3p RAPGEF6 -0.08 0.76348 -0.73 0.0274 mirMAP -0.12 0.03868 NA
50 hsa-miR-495-3p RAVER2 -0.08 0.76348 -1.09 0.00026 MirTarget -0.11 0.03814 NA
51 hsa-miR-495-3p RBM41 -0.08 0.76348 0.33 0.03471 MirTarget -0.14 0 NA
52 hsa-miR-495-3p REST -0.08 0.76348 -0.51 0.12682 mirMAP -0.11 0.04736 NA
53 hsa-miR-495-3p RICTOR -0.08 0.76348 -0.06 0.6908 MirTarget -0.14 0 NA
54 hsa-miR-495-3p RPRD1A -0.08 0.76348 -0.46 0.00415 MirTarget; mirMAP -0.13 0 NA
55 hsa-miR-495-3p RPRD2 -0.08 0.76348 -0.2 0.17665 MirTarget; mirMAP -0.12 0 NA
56 hsa-miR-495-3p SATB1 -0.08 0.76348 -1.42 0 MirTarget -0.11 0.03689 NA
57 hsa-miR-495-3p SECISBP2L -0.08 0.76348 -0.85 0 mirMAP -0.12 9.0E-5 NA
58 hsa-miR-495-3p SESTD1 -0.08 0.76348 -0.83 0.00021 MirTarget -0.11 0.0064 NA
59 hsa-miR-495-3p SHANK2 -0.08 0.76348 0.06 0.89153 mirMAP -0.16 0.02975 NA
60 hsa-miR-495-3p SHPRH -0.08 0.76348 -0.61 0.05462 MirTarget -0.14 0.00986 NA
61 hsa-miR-495-3p SLC25A36 -0.08 0.76348 0.38 0.00819 mirMAP -0.12 0 NA
62 hsa-miR-495-3p SMAD3 -0.08 0.76348 -0.15 0.56924 mirMAP -0.15 0.00081 NA
63 hsa-miR-495-3p SSBP2 -0.08 0.76348 -1.5 0 mirMAP -0.11 0.019 NA
64 hsa-miR-495-3p ST3GAL1 -0.08 0.76348 -0.55 0.06526 mirMAP -0.18 0.00053 NA
65 hsa-miR-495-3p STAG1 -0.08 0.76348 -0.25 0.20245 mirMAP -0.11 0.00137 NA
66 hsa-miR-495-3p TGFBRAP1 -0.08 0.76348 -0.03 0.90174 mirMAP -0.1 0.02809 NA
67 hsa-miR-495-3p THOC2 -0.08 0.76348 0.21 0.15096 mirMAP -0.13 0 NA
68 hsa-miR-495-3p THRB -0.08 0.76348 -0.97 0.01155 MirTarget -0.14 0.04138 NA
69 hsa-miR-495-3p TMEM154 -0.08 0.76348 0.6 0.08197 mirMAP -0.13 0.03461 NA
70 hsa-miR-495-3p TMEM181 -0.08 0.76348 -0.1 0.49884 mirMAP -0.1 6.0E-5 NA
71 hsa-miR-495-3p TMX4 -0.08 0.76348 -0.93 0 MirTarget -0.12 0.0001 NA
72 hsa-miR-495-3p TOR1AIP2 -0.08 0.76348 0.07 0.73308 MirTarget -0.1 0.00531 NA
73 hsa-miR-495-3p TTBK2 -0.08 0.76348 -1.27 0 mirMAP -0.11 0.01357 NA
74 hsa-miR-495-3p UBA6 -0.08 0.76348 0.51 0.00329 MirTarget; mirMAP -0.1 0.00052 NA
75 hsa-miR-495-3p UBXN7 -0.08 0.76348 0 0.99285 mirMAP -0.11 0.00561 NA
76 hsa-miR-495-3p USP49 -0.08 0.76348 0.32 0.24255 mirMAP -0.11 0.01645 NA
77 hsa-miR-495-3p VPS13A -0.08 0.76348 -0.28 0.16903 mirMAP -0.13 0.00012 NA
78 hsa-miR-495-3p ZCCHC2 -0.08 0.76348 -0.45 0.00556 mirMAP -0.11 6.0E-5 NA
79 hsa-miR-495-3p ZDHHC21 -0.08 0.76348 -0.41 0.07107 MirTarget; mirMAP -0.13 0.00124 NA
80 hsa-miR-495-3p ZFX -0.08 0.76348 -0.67 7.0E-5 MirTarget -0.1 0.00064 NA
81 hsa-miR-495-3p ZNF280C -0.08 0.76348 0.33 0.06099 MirTarget -0.1 0.00076 NA
82 hsa-miR-495-3p ZNF292 -0.08 0.76348 -0.2 0.29898 MirTarget; mirMAP -0.12 0.00031 NA
83 hsa-miR-495-3p ZNF572 -0.08 0.76348 0.74 0.01979 mirMAP -0.11 0.04668 NA
84 hsa-miR-495-3p ZNF780B -0.08 0.76348 -0.23 0.21612 mirMAP -0.12 0.00025 NA
85 hsa-miR-495-3p ZNF81 -0.08 0.76348 0.25 0.2004 mirMAP -0.1 0.00276 NA
86 hsa-miR-495-3p ZNF827 -0.08 0.76348 -0.81 0.00778 mirMAP -0.13 0.01331 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04720_Long.term_potentiation 3 70 0.003414 0.6145
2 hsa04310_Wnt_signaling_pathway 3 151 0.02738 0.9724
3 hsa04730_Long.term_depression 2 70 0.03655 0.9724
4 hsa04520_Adherens_junction 2 73 0.03945 0.9724
5 hsa04971_Gastric_acid_secretion 2 74 0.04043 0.9724
6 hsa04070_Phosphatidylinositol_signaling_system 2 78 0.04446 0.9724
7 hsa04012_ErbB_signaling_pathway 2 87 0.05404 0.9724
8 hsa04510_Focal_adhesion 3 200 0.05515 0.9724
9 hsa04912_GnRH_signaling_pathway 2 101 0.07023 0.9724
10 hsa04916_Melanogenesis 2 101 0.07023 0.9724
11 hsa04114_Oocyte_meiosis 2 114 0.08647 1
12 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.08906 1
13 hsa04110_Cell_cycle 2 128 0.1051 1
14 hsa04530_Tight_junction 2 133 0.112 1
15 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.1204 1
16 hsa04390_Hippo_signaling_pathway 2 154 0.1421 1
17 hsa04020_Calcium_signaling_pathway 2 177 0.1767 1
18 hsa04151_PI3K_AKT_signaling_pathway 3 351 0.1921 1
19 hsa04144_Endocytosis 2 203 0.2173 1
20 hsa04014_Ras_signaling_pathway 2 236 0.2697 1
21 hsa04010_MAPK_signaling_pathway 2 268 0.3206 1

Quest ID: 96c558dd4467c2c34eafa44b8e4c66d5