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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p FAT2 1.39 6.0E-5 0.76 0.16582 MirTarget; miRNATAP -0.19 0.01838 NA
2 hsa-miR-128-3p FAT2 1.04 0 0.76 0.16582 MirTarget -0.39 0.01121 NA
3 hsa-miR-17-3p FAT2 1.37 0 0.76 0.16582 miRNAWalker2 validate -0.61 0 NA
4 hsa-miR-17-5p FAT2 2.07 0 0.76 0.16582 MirTarget; TargetScan; miRNATAP -0.34 0.001 NA
5 hsa-miR-183-5p FAT2 2.39 0 0.76 0.16582 miRNAWalker2 validate -0.26 0.0063 NA
6 hsa-miR-326 FAT2 -0.99 0.00335 0.76 0.16582 miRanda -0.19 0.00866 NA
7 hsa-miR-330-3p FAT2 -0.72 0.0008 0.76 0.16582 MirTarget -0.36 0.00201 NA
8 hsa-miR-330-5p FAT2 0.17 0.33643 0.76 0.16582 miRanda -0.78 0 NA
9 hsa-miR-550a-5p FAT2 0.6 0.03148 0.76 0.16582 MirTarget -0.24 0.00851 NA
10 hsa-miR-664a-5p FOXE1 -0.09 0.66227 2.22 0.00388 mirMAP -0.37 0.03127 NA
11 hsa-miR-326 GJB3 -0.99 0.00335 1.18 0.05826 miRanda -0.48 0 NA
12 hsa-miR-491-5p GJB3 -0.47 0.06833 1.18 0.05826 miRanda -0.29 0.00998 NA
13 hsa-miR-335-5p GJB4 -0.47 0.0677 1.09 0.08132 miRNAWalker2 validate -0.37 0.00358 NA
14 hsa-miR-328-3p GJB5 -0.97 0.00067 1.01 0.11643 MirTarget -0.24 0.02221 NA
15 hsa-miR-335-5p GJB5 -0.47 0.0677 1.01 0.11643 miRNAWalker2 validate -0.3 0.02212 NA
16 hsa-miR-500a-3p GJB5 -0.14 0.54575 1.01 0.11643 MirTarget -0.31 0.01877 NA
17 hsa-miR-335-5p GPR87 -0.47 0.0677 2.65 0.0006 miRNAWalker2 validate -0.59 0.00016 NA
18 hsa-miR-139-5p HOXA13 -2.27 0 1.54 0.00935 miRanda -0.36 0.00013 NA
19 hsa-miR-195-3p HOXA13 -1.33 0 1.54 0.00935 mirMAP -0.29 0.01334 NA
20 hsa-miR-3065-5p HOXA13 0.65 0.09995 1.54 0.00935 mirMAP -0.26 0.00054 NA
21 hsa-miR-326 HOXA13 -0.99 0.00335 1.54 0.00935 miRanda -0.24 0.0026 NA
22 hsa-miR-338-5p HOXA13 -1.83 0 1.54 0.00935 mirMAP -0.25 0.00065 NA
23 hsa-miR-664a-3p HOXA13 0.44 0.02142 1.54 0.00935 mirMAP -0.5 0.00041 NA
24 hsa-miR-324-5p IGFL1 1.07 5.0E-5 0.79 0.14576 miRanda -0.19 0.04056 NA
25 hsa-miR-92a-1-5p IVL -0.21 0.48786 1.21 0.16954 MirTarget -0.34 0.01661 NA
26 hsa-miR-421 KRT15 0.17 0.53528 1.8 0.0002 mirMAP -0.29 0.00111 NA
27 hsa-miR-146b-5p KRT6B 1.09 1.0E-5 2.42 0.00364 miRanda -0.33 0.03508 NA
28 hsa-miR-30d-3p KRT6C 0 0.98646 2.55 0.00106 MirTarget -1.12 0 NA
29 hsa-miR-30e-3p KRT6C -0.1 0.52624 2.55 0.00106 MirTarget -0.65 0.00315 NA
30 hsa-miR-27b-3p LYPD3 0.24 0.12264 2.06 1.0E-5 MirTarget; miRNATAP -0.28 0.0471 NA
31 hsa-miR-326 LYPD3 -0.99 0.00335 2.06 1.0E-5 miRanda -0.3 0 NA
32 hsa-miR-335-5p LYPD3 -0.47 0.0677 2.06 1.0E-5 miRNAWalker2 validate -0.32 0.00049 NA
33 hsa-miR-455-5p LYPD3 1.37 0 2.06 1.0E-5 MirTarget; miRanda; miRNATAP -0.26 0.00703 NA
34 hsa-miR-450b-5p NTS 1.69 0 -1.57 0.05001 miRNATAP -0.42 0.00083 NA
35 hsa-miR-326 PADI1 -0.99 0.00335 3.39 0 miRNATAP -0.38 0.00014 NA
36 hsa-miR-330-5p PADI1 0.17 0.33643 3.39 0 miRNATAP -0.48 0.01594 NA
37 hsa-miR-664a-5p PADI1 -0.09 0.66227 3.39 0 mirMAP -0.61 0.00023 NA
38 hsa-miR-330-3p PADI3 -0.72 0.0008 2.23 0.00193 miRNATAP -0.34 0.02942 NA
39 hsa-miR-1226-3p PKP1 -1.01 0.00515 -0.05 0.94754 MirTarget -0.29 0.00487 NA
40 hsa-miR-1976 PKP1 -1.28 0 -0.05 0.94754 MirTarget -0.37 0.01552 NA
41 hsa-miR-224-5p PKP1 1.92 0 -0.05 0.94754 mirMAP -0.29 0.00016 NA
42 hsa-miR-532-3p PKP1 -0.68 0.01476 -0.05 0.94754 mirMAP -0.23 0.04068 NA
43 hsa-miR-421 PTPRZ1 0.17 0.53528 -0.14 0.83819 miRanda -0.43 0.00035 NA
44 hsa-miR-16-5p SERPINB5 0.75 0 2.18 0.00822 miRNAWalker2 validate -0.48 0.03926 NA
45 hsa-miR-491-5p SERPINB7 -0.47 0.06833 1.23 0.06507 miRanda -0.31 0.00964 NA
46 hsa-miR-628-5p SERPINB7 1.06 0 1.23 0.06507 miRNATAP -0.43 0.00667 NA
47 hsa-miR-3065-5p SOX21 0.65 0.09995 1.33 0.04217 mirMAP; miRNATAP -0.19 0.02017 NA
48 hsa-miR-330-5p SPRR1B 0.17 0.33643 3.15 0.00024 miRanda -0.93 4.0E-5 NA
49 hsa-miR-590-5p SPRR1B 2.07 0 3.15 0.00024 miRanda -0.36 0.04116 NA
50 hsa-miR-326 SPRR2A -0.99 0.00335 -0.81 0.19244 miRanda -0.32 0.00013 NA
51 hsa-miR-330-5p SPRR2A 0.17 0.33643 -0.81 0.19244 miRanda -0.8 0 NA
52 hsa-miR-421 SPRR2A 0.17 0.53528 -0.81 0.19244 miRanda -0.3 0.00761 NA
53 hsa-miR-664a-5p SPRR2A -0.09 0.66227 -0.81 0.19244 MirTarget -0.29 0.03706 NA
54 hsa-miR-326 SPRR2D -0.99 0.00335 1.27 0.09226 miRanda -0.43 2.0E-5 NA
55 hsa-miR-330-5p SPRR2D 0.17 0.33643 1.27 0.09226 miRanda -0.86 1.0E-5 NA
56 hsa-miR-421 SPRR2D 0.17 0.53528 1.27 0.09226 miRanda -0.43 0.00205 NA
57 hsa-miR-330-5p TMPRSS11D 0.17 0.33643 1.32 0.01713 miRanda -0.39 0.00753 NA
58 hsa-miR-30b-3p TNS4 -1.21 0 2.58 4.0E-5 MirTarget -0.61 0 NA
59 hsa-miR-335-5p TNS4 -0.47 0.0677 2.58 4.0E-5 miRNAWalker2 validate -0.69 0 NA
60 hsa-miR-491-5p TNS4 -0.47 0.06833 2.58 4.0E-5 mirMAP -0.28 0.01452 NA
61 hsa-miR-146b-5p UPK1B 1.09 1.0E-5 -1.18 0.14389 miRanda -0.53 0.00058 NA
62 hsa-miR-326 UPK1B -0.99 0.00335 -1.18 0.14389 miRanda -0.29 0.00888 NA
63 hsa-miR-542-3p UPK1B 1.62 0 -1.18 0.14389 miRanda -0.36 0.01083 NA
64 hsa-miR-335-5p VTCN1 -0.47 0.0677 2.15 0.00052 miRNAWalker2 validate -0.28 0.02587 NA
65 hsa-miR-181c-5p ZIC2 0.53 0.01259 3.17 2.0E-5 MirTarget; miRNATAP -0.83 0 NA
66 hsa-miR-181d-5p ZIC2 1.19 0 3.17 2.0E-5 MirTarget -0.56 0.00065 NA
67 hsa-miR-30d-5p ZIC2 -0.92 4.0E-5 3.17 2.0E-5 miRNATAP -0.61 6.0E-5 NA
68 hsa-miR-338-5p ZIC2 -1.83 0 3.17 2.0E-5 PITA -0.45 0 NA
69 hsa-miR-326 ZIC5 -0.99 0.00335 1.92 0.00249 PITA; miRanda -0.3 0.00045 NA
70 hsa-miR-375 ZIC5 0.62 0.1492 1.92 0.00249 miRanda -0.29 3.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 EPIDERMIS DEVELOPMENT 8 253 2.702e-09 1.257e-05
2 SKIN DEVELOPMENT 7 211 2.182e-08 5.076e-05
3 EPITHELIUM DEVELOPMENT 10 945 6.696e-07 0.001039
4 KERATINIZATION 4 50 9.027e-07 0.00105
5 PEPTIDE CROSS LINKING 4 56 1.431e-06 0.001331
6 TISSUE DEVELOPMENT 11 1518 6.567e-06 0.005092
NumGOOverlapSizeP ValueAdj. P Value
1 STRUCTURAL MOLECULE ACTIVITY 9 732 8.042e-07 0.0007471
NumGOOverlapSizeP ValueAdj. P Value
1 CORNIFIED ENVELOPE 4 45 5.871e-07 0.0003429
2 CONNEXON COMPLEX 3 20 3.413e-06 0.0009965
3 GAP JUNCTION 3 30 1.203e-05 0.002342
4 INTERMEDIATE FILAMENT CYTOSKELETON 5 239 2.609e-05 0.003809

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

Quest ID: 9a67af68a20337bdf82e5bd1666ce7a3