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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p AIFM1 -0.33 0.00046 -0.39 0.00049 TargetScan; miRNATAP -0.16 0.00689 NA
2 hsa-let-7b-5p AIFM1 -0.96 0 -0.39 0.00049 miRNATAP -0.09 0.0139 NA
3 hsa-let-7d-5p AIFM1 0.05 0.70258 -0.39 0.00049 miRNATAP -0.23 0 NA
4 hsa-let-7e-5p AIFM1 0.04 0.81107 -0.39 0.00049 miRNATAP -0.27 0 NA
5 hsa-let-7i-5p AIFM1 -0.14 0.15414 -0.39 0.00049 miRNATAP -0.27 0 NA
6 hsa-miR-125a-5p AIFM1 -0.91 0 -0.39 0.00049 miRanda -0.14 0 NA
7 hsa-miR-155-5p AIFM1 0.01 0.95651 -0.39 0.00049 miRNAWalker2 validate -0.09 0.00127 NA
8 hsa-miR-20a-3p AIFM1 -0.32 0.04679 -0.39 0.00049 miRNATAP -0.11 0.00067 NA
9 hsa-miR-425-5p AIFM1 0.59 2.0E-5 -0.39 0.00049 miRNATAP -0.15 8.0E-5 NA
10 hsa-miR-429 AIFM1 -1.4 7.0E-5 -0.39 0.00049 miRNATAP -0.09 0 NA
11 hsa-miR-125a-5p AKT2 -0.91 0 -0.34 1.0E-5 mirMAP -0.05 0.0142 NA
12 hsa-miR-149-5p AKT2 -0.32 0.18721 -0.34 1.0E-5 miRNAWalker2 validate -0.08 0 NA
13 hsa-miR-183-5p AKT2 2.33 0 -0.34 1.0E-5 mirMAP -0.06 0 NA
14 hsa-miR-1976 AKT2 -0.43 0.00325 -0.34 1.0E-5 miRNATAP -0.05 0.04381 NA
15 hsa-miR-21-5p AKT2 1.51 0 -0.34 1.0E-5 miRNAWalker2 validate -0.25 0 NA
16 hsa-miR-330-5p AKT2 0.44 0.00533 -0.34 1.0E-5 miRanda -0.1 1.0E-5 NA
17 hsa-miR-338-3p AKT2 0.54 0.00461 -0.34 1.0E-5 mirMAP -0.09 0 NA
18 hsa-miR-342-3p AKT2 -0.32 0.04498 -0.34 1.0E-5 mirMAP -0.12 0 NA
19 hsa-miR-671-5p AKT2 0.84 0 -0.34 1.0E-5 miRNATAP -0.06 0.01107 NA
20 hsa-miR-766-3p AKT2 0.2 0.25723 -0.34 1.0E-5 mirMAP -0.06 0.00542 NA
21 hsa-miR-106b-5p AKT3 0.65 0 -0.66 0.00047 miRNATAP -0.26 0.00148 NA
22 hsa-miR-107 AKT3 0.24 0.01708 -0.66 0.00047 PITA; miRanda -0.6 0 NA
23 hsa-miR-122-5p AKT3 -1.24 0 -0.66 0.00047 miRNAWalker2 validate; miRTarBase -0.28 0 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer
24 hsa-miR-146b-5p AKT3 0.42 0.04574 -0.66 0.00047 miRNAWalker2 validate -0.16 0.00026 NA
25 hsa-miR-15a-5p AKT3 0.35 0.00077 -0.66 0.00047 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.00291 NA
26 hsa-miR-17-3p AKT3 0.41 0.00422 -0.66 0.00047 miRNATAP -0.35 0 NA
27 hsa-miR-17-5p AKT3 0.7 2.0E-5 -0.66 0.00047 TargetScan; miRNATAP -0.29 0 NA
28 hsa-miR-20a-5p AKT3 0.85 0 -0.66 0.00047 miRNATAP -0.29 0 NA
29 hsa-miR-32-3p AKT3 0.22 0.20722 -0.66 0.00047 mirMAP -0.23 4.0E-5 NA
30 hsa-miR-33a-3p AKT3 -0.68 1.0E-5 -0.66 0.00047 mirMAP -0.23 0.0001 NA
31 hsa-miR-362-3p AKT3 0.81 0 -0.66 0.00047 miRanda -0.22 0.00083 NA
32 hsa-miR-362-5p AKT3 0.72 2.0E-5 -0.66 0.00047 PITA; TargetScan; miRNATAP -0.15 0.00734 NA
33 hsa-miR-374a-5p AKT3 0.02 0.86978 -0.66 0.00047 mirMAP -0.28 0.00294 NA
34 hsa-miR-421 AKT3 0.94 0 -0.66 0.00047 miRanda; mirMAP -0.13 0.01091 NA
35 hsa-miR-501-3p AKT3 1 0 -0.66 0.00047 miRNATAP -0.12 0.04823 NA
36 hsa-miR-502-3p AKT3 0.66 0 -0.66 0.00047 miRNATAP -0.26 0.0008 NA
37 hsa-miR-616-5p AKT3 0.15 0.40284 -0.66 0.00047 mirMAP -0.2 0.0001 NA
38 hsa-miR-93-5p AKT3 1.4 0 -0.66 0.00047 miRNATAP -0.28 1.0E-5 NA
39 hsa-miR-139-5p APAF1 -2.11 0 0.22 0.0143 mirMAP -0.1 1.0E-5 NA
40 hsa-miR-3607-3p APAF1 -2.16 0 0.22 0.0143 mirMAP; miRNATAP -0.07 0.00025 NA
41 hsa-miR-30d-3p ATM -0.12 0.32955 -0.24 0.01738 mirMAP -0.14 0.00043 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC
42 hsa-miR-30d-5p ATM 0.72 0 -0.24 0.01738 mirMAP -0.08 0.03814 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC
43 hsa-miR-324-5p ATM 0.37 0.00592 -0.24 0.01738 miRanda -0.09 0.009 NA
44 hsa-miR-339-5p ATM 0.28 0.03557 -0.24 0.01738 miRanda -0.1 0.00399 NA
45 hsa-miR-455-5p ATM -0.27 0.05813 -0.24 0.01738 miRanda -0.12 0.00045 NA
46 hsa-miR-127-3p BAD -1.08 2.0E-5 0.07 0.50941 miRanda; miRNATAP -0.07 0.00096 NA
47 hsa-miR-122-5p BAX -1.24 0 0.8 0 miRNAWalker2 validate -0.09 0 NA
48 hsa-miR-30a-5p BAX -0.63 0.00011 0.8 0 miRNAWalker2 validate -0.12 0.00058 NA
49 hsa-miR-365a-3p BAX 0.16 0.15325 0.8 0 miRNAWalker2 validate -0.23 0 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX
50 hsa-miR-103a-3p BCL2 0.77 0 -0.35 0.02497 miRNAWalker2 validate -0.28 4.0E-5 NA
51 hsa-miR-130b-5p BCL2 0.17 0.33761 -0.35 0.02497 mirMAP -0.17 7.0E-5 27364335 The level of microRNA-130b in relationship with the expression of PPARĪ³ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARĪ³ up-regulation of VEGF-A and BCL-2 and decreased apoptosis
52 hsa-miR-148a-3p BCL2 -0.75 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
53 hsa-miR-15a-5p BCL2 0.35 0.00077 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.17 0.02172 25594541; 26915294; 18931683; 25623762; 22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05
54 hsa-miR-15b-3p BCL2 0.24 0.09977 -0.35 0.02497 mirMAP -0.1 0.04638 26884837; 25594541; 26915294; 18449891 MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
55 hsa-miR-17-5p BCL2 0.7 2.0E-5 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
56 hsa-miR-186-5p BCL2 -0.06 0.53529 -0.35 0.02497 mirMAP -0.25 0.00125 NA
57 hsa-miR-192-5p BCL2 -0.5 0.00345 -0.35 0.02497 miRNAWalker2 validate -0.34 0 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
58 hsa-miR-204-5p BCL2 -0.54 0.03309 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.08 0.00496 25652855; 23152059; 26191195; 27519795; 25209181 The expressions of Bcl-2 and Sirt1 in the lower miR-204 level group were both higher than those in the higher miR-204 level group; Correlation analysis showed that miR-204 expression was negatively correlated with Bcl-2 and Sirt1 protein expression levels; Over-expressed miR-204 in SMMC-7721 cells suppressed cell proliferation and promoted cell apoptosis and down-regulated mRNA and protein expressions of both Bcl-2 and Sirt1; miR-204 could inhibit HCC cell proliferation and induce apoptosis by down-regulating the expressions of Bcl-2 and Sirt1;miR 204 targets Bcl 2 expression and enhances responsiveness of gastric cancer; Downregulation of miR-204 has prognostic value and correlates with increased staining of Bcl-2 protein in tumoral specimens; miR-204 targeted Bcl-2 messenger RNA and increased responsiveness of GC cells to 5-fluorouracil and oxaliplatin treatment; Ectopic expression of Bcl-2 protein counteracted miR-204 pro-apoptotic activity in response to 5-fluorouracil; Altogether these findings suggest that modulation of aberrant expression of miR-204 which in turn releases oncogenic Bcl-2 protein activity might hold promise for preventive and therapeutic strategies of GC;Moreover the level of miR-204 is negatively correlated with p-STAT3 and anti-apoptotic genes BCl-2 and surviving in breast cancer;Human miR-204-5p potentially targeting BCL2 has been reported to be downregulated in various cancers; We hypothesized that miR-204-5p overexpression induces cancer cell apoptosis by repressing BCL2 expression; Luciferase reporter assays were performed to verify the function of mature miR-204-5p and its direct binding to BCL2 transcripts; Human miR-204-5p targets BCL2 in PCa cells; Restoration of miR-204-5p in PCa could therefore be considered as a novel strategy by targeting antiapoptotic BCL2;This may be explained by the fact that miR-204-5p increases in colorectal cancer cases in order to inhibit increased activity of LC3B-II in autophagy and Bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor
59 hsa-miR-20a-3p BCL2 -0.32 0.04679 -0.35 0.02497 mirMAP -0.24 0 NA
60 hsa-miR-20a-5p BCL2 0.85 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 NA
61 hsa-miR-32-3p BCL2 0.22 0.20722 -0.35 0.02497 mirMAP -0.2 1.0E-5 NA
62 hsa-miR-33a-5p BCL2 -0.77 1.0E-5 -0.35 0.02497 mirMAP -0.11 0.01041 NA
63 hsa-miR-34a-5p BCL2 1.04 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.11 0.03329 23862748; 24565525; 23155233; 24444609; 20687223; 22623155; 24988056; 18803879; 19714243; 25053345; 20433755; 21399894; 22964582 MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression;InĀ vitro and inĀ vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2
64 hsa-miR-365a-3p BCL2 0.16 0.15325 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.33 0 NA
65 hsa-miR-374a-5p BCL2 0.02 0.86978 -0.35 0.02497 mirMAP -0.18 0.02111 NA
66 hsa-miR-455-5p BCL2 -0.27 0.05813 -0.35 0.02497 mirMAP -0.19 0.00037 NA
67 hsa-miR-590-5p BCL2 -0.1 0.31003 -0.35 0.02497 miRanda -0.29 0.00011 NA
68 hsa-miR-616-5p BCL2 0.15 0.40284 -0.35 0.02497 mirMAP -0.28 0 NA
69 hsa-miR-618 BCL2 0.14 0.51715 -0.35 0.02497 mirMAP -0.21 0 NA
70 hsa-miR-142-3p BCL2L1 -1.42 0 0.02 0.82745 miRNATAP -0.09 0.00098 NA
71 hsa-miR-149-5p BCL2L1 -0.32 0.18721 0.02 0.82745 mirMAP -0.05 0.01088 NA
72 hsa-miR-326 BCL2L1 -1.88 0 0.02 0.82745 PITA; miRanda; mirMAP; miRNATAP -0.09 0.00045 NA
73 hsa-miR-330-5p BCL2L1 0.44 0.00533 0.02 0.82745 PITA; miRanda; miRNATAP -0.15 0 NA
74 hsa-miR-342-3p BCL2L1 -0.32 0.04498 0.02 0.82745 PITA; miRanda; miRNATAP -0.12 8.0E-5 NA
75 hsa-miR-342-5p BCL2L1 -0.78 0 0.02 0.82745 miRNATAP -0.11 0.00084 NA
76 hsa-miR-484 BCL2L1 0.09 0.45398 0.02 0.82745 miRNAWalker2 validate -0.21 0 NA
77 hsa-miR-491-5p BCL2L1 -0.37 0.0154 0.02 0.82745 miRNAWalker2 validate; miRTarBase; MirTarget; miRanda -0.08 0.01586 25299770; 20039318; 23519249 We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-XL expression and by inducing BIM accumulation in its dephosphorylated form;Functional screening identifies a microRNA miR 491 that induces apoptosis by targeting Bcl XL in colorectal cancer cells; We demonstrated that Bcl-XL was a direct target of miR-491 and its silencing contributed to miR-491-induced apoptosis; Our study provides a new regulation of Bcl-XL by miR-491 in colorectal cancer cells and suggests a therapeutic potential of miRNAs for treating colorectal cancer by targeting Bcl-XL;Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions
78 hsa-miR-940 BCL2L1 0.45 0.01771 0.02 0.82745 mirMAP -0.08 0.00373 NA
79 hsa-miR-140-5p BID -0.22 0.01407 0.21 0.07516 miRanda -0.21 0.00101 NA
80 hsa-miR-29b-3p BIRC2 -0.35 0.01214 -0.32 0 MirTarget -0.06 0.00892 NA
81 hsa-miR-330-3p BIRC2 -0.33 0.03161 -0.32 0 miRNATAP -0.06 0.00998 NA
82 hsa-miR-500a-5p BIRC2 0.8 0 -0.32 0 MirTarget -0.07 0.00137 NA
83 hsa-miR-24-1-5p BIRC3 -1.32 0 0.35 0.15976 MirTarget -0.3 0.0004 NA
84 hsa-miR-26b-5p BIRC3 -1.11 0 0.35 0.15976 mirMAP -0.35 0.00041 NA
85 hsa-miR-374a-5p BIRC3 0.02 0.86978 0.35 0.15976 mirMAP -0.56 0 NA
86 hsa-miR-374b-5p BIRC3 -0.31 0.00301 0.35 0.15976 mirMAP -0.3 0.0093 NA
87 hsa-miR-616-3p BIRC3 -0.7 2.0E-5 0.35 0.15976 MirTarget -0.15 0.046 NA
88 hsa-miR-651-5p BIRC3 -0.24 0.08175 0.35 0.15976 MirTarget -0.28 0.00126 NA
89 hsa-miR-664a-3p BIRC3 0.49 0.00073 0.35 0.15976 mirMAP -0.27 0.00118 NA
90 hsa-miR-140-5p CAPN1 -0.22 0.01407 0.2 0.01338 miRanda; miRNATAP -0.15 0.00087 NA
91 hsa-miR-101-3p CAPN2 -1.48 0 0.66 0 miRNAWalker2 validate; MirTarget -0.21 0 NA
92 hsa-miR-107 CAPN2 0.24 0.01708 0.66 0 miRanda -0.2 0.00125 NA
93 hsa-miR-1468-5p CAPN2 -1.21 0 0.66 0 MirTarget -0.1 0.00079 NA
94 hsa-miR-16-2-3p CAPN2 -0.03 0.80516 0.66 0 mirMAP -0.15 0.0006 NA
95 hsa-miR-20a-3p CAPN2 -0.32 0.04679 0.66 0 MirTarget -0.13 0.00067 NA
96 hsa-miR-299-5p CAPN2 -1.29 0 0.66 0 MirTarget -0.06 0.01237 NA
97 hsa-miR-33a-3p CAPN2 -0.68 1.0E-5 0.66 0 mirMAP -0.13 0.00096 NA
98 hsa-miR-421 CAPN2 0.94 0 0.66 0 miRanda -0.07 0.03811 NA
99 hsa-miR-548j-5p CAPN2 0.25 0.17136 0.66 0 MirTarget -0.07 0.04097 NA
100 hsa-miR-590-3p CAPN2 -0.47 2.0E-5 0.66 0 miRanda -0.22 5.0E-5 NA
101 hsa-miR-590-5p CAPN2 -0.1 0.31003 0.66 0 miRanda -0.24 5.0E-5 NA
102 hsa-miR-30b-3p CASP10 -0.44 0.00095 -0.16 0.06144 MirTarget -0.07 0.02213 NA
103 hsa-let-7g-5p CASP3 -0.46 2.0E-5 0.31 0.00047 MirTarget; miRNATAP -0.11 0.00694 NA
104 hsa-miR-101-3p CASP3 -1.48 0 0.31 0.00047 MirTarget -0.09 0.00599 NA
105 hsa-miR-139-5p CASP3 -2.11 0 0.31 0.00047 miRanda -0.07 0.0008 NA
106 hsa-miR-140-5p CASP3 -0.22 0.01407 0.31 0.00047 miRanda -0.1 0.03228 NA
107 hsa-miR-30a-5p CASP3 -0.63 0.00011 0.31 0.00047 miRNATAP -0.07 0.00479 NA
108 hsa-miR-374b-5p CASP3 -0.31 0.00301 0.31 0.00047 mirMAP -0.14 0.00058 NA
109 hsa-miR-106b-5p CASP7 0.65 0 -0.72 0 miRNAWalker2 validate -0.09 0.04918 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited
110 hsa-miR-664a-3p CASP7 0.49 0.00073 -0.72 0 MirTarget -0.1 0.00545 NA
111 hsa-miR-107 CASP8 0.24 0.01708 0.33 0.00029 miRanda -0.11 0.01137 NA
112 hsa-miR-143-3p CASP8 -0.58 0.00091 0.33 0.00029 MirTarget -0.05 0.03237 NA
113 hsa-miR-26b-5p CASP8 -1.11 0 0.33 0.00029 miRNAWalker2 validate -0.09 0.02018 NA
114 hsa-miR-455-5p CASP8 -0.27 0.05813 0.33 0.00029 miRanda -0.15 0 NA
115 hsa-miR-542-3p CASP8 -1.31 0 0.33 0.00029 miRanda -0.13 4.0E-5 NA
116 hsa-miR-17-5p CASP9 0.7 2.0E-5 -0.17 0.12115 TargetScan -0.08 0.00899 NA
117 hsa-miR-199a-3p CASP9 -2.33 0 -0.17 0.12115 mirMAP -0.05 0.00586 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol
118 hsa-miR-199b-3p CASP9 -2.33 0 -0.17 0.12115 mirMAP -0.05 0.00585 NA
119 hsa-miR-222-5p CASP9 0.13 0.48742 -0.17 0.12115 mirMAP -0.09 0.00171 NA
120 hsa-miR-103a-2-5p CFLAR 1.17 0 -0.33 0 mirMAP -0.06 0.00057 NA
121 hsa-miR-107 CFLAR 0.24 0.01708 -0.33 0 miRanda -0.15 1.0E-5 NA
122 hsa-miR-130b-3p CFLAR 0.69 0.00011 -0.33 0 mirMAP -0.05 0.00441 NA
123 hsa-miR-301a-3p CFLAR 0.84 0 -0.33 0 mirMAP -0.06 0.00213 NA
124 hsa-miR-339-5p CFLAR 0.28 0.03557 -0.33 0 miRanda -0.08 0.0011 NA
125 hsa-miR-455-5p CFLAR -0.27 0.05813 -0.33 0 miRanda -0.11 0 NA
126 hsa-miR-660-5p CFLAR 0.99 0 -0.33 0 mirMAP -0.13 0 NA
127 hsa-miR-582-5p CHP2 -0.68 0.00104 0.85 0.03429 miRNATAP -0.22 0.02359 NA
128 hsa-miR-15a-5p CHUK 0.35 0.00077 -0.2 0.00863 miRNAWalker2 validate; miRTarBase; MirTarget -0.12 0.00057 NA
129 hsa-miR-15b-5p CHUK 0.23 0.08248 -0.2 0.00863 MirTarget -0.12 2.0E-5 NA
130 hsa-miR-16-5p CHUK -0.4 0.0001 -0.2 0.00863 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 3.0E-5 NA
131 hsa-miR-23a-3p CHUK -0.18 0.13598 -0.2 0.00863 MirTarget -0.1 0.00114 NA
132 hsa-miR-29b-2-5p CHUK -0.22 0.08431 -0.2 0.00863 MirTarget -0.07 0.02235 NA
133 hsa-miR-339-5p CHUK 0.28 0.03557 -0.2 0.00863 miRanda -0.12 1.0E-5 NA
134 hsa-miR-342-3p CHUK -0.32 0.04498 -0.2 0.00863 miRanda -0.06 0.00622 NA
135 hsa-miR-497-5p CHUK -1.41 0 -0.2 0.00863 MirTarget -0.05 0.01421 NA
136 hsa-miR-590-5p CHUK -0.1 0.31003 -0.2 0.00863 miRanda -0.12 0.00129 NA
137 hsa-miR-19a-3p CSF2RB 1.02 0 -0.51 0.00683 MirTarget -0.12 0.00885 NA
138 hsa-miR-19b-3p CSF2RB 0.6 0.00017 -0.51 0.00683 MirTarget -0.15 0.00713 NA
139 hsa-miR-204-5p CSF2RB -0.54 0.03309 -0.51 0.00683 MirTarget -0.11 0.00224 NA
140 hsa-miR-30b-3p CSF2RB -0.44 0.00095 -0.51 0.00683 MirTarget -0.2 0.00366 NA
141 hsa-miR-455-5p CSF2RB -0.27 0.05813 -0.51 0.00683 miRanda -0.37 0 NA
142 hsa-miR-532-5p CSF2RB 1.03 0 -0.51 0.00683 MirTarget -0.33 0 NA
143 hsa-miR-139-5p CYCS -2.11 0 0.26 0.01519 miRanda -0.06 0.02282 NA
144 hsa-miR-148a-3p CYCS -0.75 0 0.26 0.01519 miRNAWalker2 validate -0.08 0.022 NA
145 hsa-miR-361-5p CYCS 0.23 0.00962 0.26 0.01519 miRNAWalker2 validate -0.17 0.00331 NA
146 hsa-let-7b-5p DFFA -0.96 0 0.07 0.4191 miRNAWalker2 validate -0.11 8.0E-5 NA
147 hsa-miR-145-5p DFFA -1.48 0 0.07 0.4191 miRNAWalker2 validate; miRTarBase -0.06 0.00558 NA
148 hsa-miR-200b-3p DFFA -1.29 0.00027 0.07 0.4191 TargetScan; mirMAP -0.05 1.0E-5 NA
149 hsa-miR-26a-2-3p DFFA -0.55 8.0E-5 0.07 0.4191 mirMAP -0.06 0.03461 NA
150 hsa-miR-26a-5p DFFA -0.96 0 0.07 0.4191 mirMAP -0.16 4.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 50 1929 2.144e-35 9.974e-32
2 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 22 99 1.115e-34 2.593e-31
3 INTRACELLULAR SIGNAL TRANSDUCTION 46 1572 4.543e-34 7.046e-31
4 APOPTOTIC SIGNALING PATHWAY 28 289 1.295e-33 1.507e-30
5 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 21 95 4.875e-33 4.537e-30
6 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 17 39 1.039e-32 8.059e-30
7 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 25 213 4.851e-32 3.224e-29
8 ZYMOGEN ACTIVATION 21 112 2.191e-31 1.274e-28
9 CELL DEATH 38 1001 3.583e-31 1.852e-28
10 REGULATION OF CELL DEATH 42 1472 5.437e-30 2.53e-27
11 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 42 1492 9.38e-30 3.968e-27
12 POSITIVE REGULATION OF CELL COMMUNICATION 42 1532 2.728e-29 1.058e-26
13 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 21 154 2.823e-28 1.01e-25
14 POSITIVE REGULATION OF MOLECULAR FUNCTION 43 1791 8.886e-28 2.757e-25
15 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 34 876 8.397e-28 2.757e-25
16 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 43 1848 3.198e-27 9.299e-25
17 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 41 1656 1.027e-26 2.81e-24
18 PROTEIN MATURATION 23 265 2.537e-26 6.558e-24
19 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 11 13 3.281e-26 8.035e-24
20 POSITIVE REGULATION OF CATALYTIC ACTIVITY 39 1518 9.463e-26 2.202e-23
21 REGULATION OF PEPTIDASE ACTIVITY 25 392 2.722e-25 6.031e-23
22 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 20 179 4.034e-25 8.533e-23
23 RESPONSE TO OXYGEN CONTAINING COMPOUND 37 1381 7.613e-25 1.54e-22
24 POSITIVE REGULATION OF CELL DEATH 28 605 1.329e-24 2.576e-22
25 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 11 17 5.15e-24 9.584e-22
26 NEGATIVE REGULATION OF CELL DEATH 31 872 5.598e-24 1.002e-21
27 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 19 171 7.982e-24 1.376e-21
28 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 20 233 8.988e-23 1.494e-20
29 REGULATION OF PROTEOLYSIS 28 711 1.076e-22 1.727e-20
30 RESPONSE TO CYTOKINE 28 714 1.206e-22 1.87e-20
31 IMMUNE SYSTEM PROCESS 40 1984 1.407e-22 2.111e-20
32 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 11 22 2.896e-22 4.211e-20
33 REGULATION OF IMMUNE SYSTEM PROCESS 34 1403 3.65e-21 5.147e-19
34 REGULATION OF IMMUNE RESPONSE 28 858 1.672e-20 2.288e-18
35 POSITIVE REGULATION OF PROTEOLYSIS 21 363 2.631e-20 3.401e-18
36 REGULATION OF APOPTOTIC SIGNALING PATHWAY 21 363 2.631e-20 3.401e-18
37 ACTIVATION OF IMMUNE RESPONSE 22 427 3.453e-20 4.343e-18
38 POSITIVE REGULATION OF IMMUNE RESPONSE 24 563 3.966e-20 4.856e-18
39 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 16 153 1.074e-19 1.281e-17
40 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 11 34 1.137e-19 1.322e-17
41 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 98 2.704e-19 3.069e-17
42 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 29 1135 2.214e-18 2.453e-16
43 REGULATION OF TRANSFERASE ACTIVITY 27 946 3.015e-18 3.262e-16
44 RESPONSE TO NITROGEN COMPOUND 26 859 3.658e-18 3.869e-16
45 INTRINSIC APOPTOTIC SIGNALING PATHWAY 15 152 4.061e-18 4.199e-16
46 REGULATION OF KINASE ACTIVITY 25 776 4.448e-18 4.499e-16
47 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 26 867 4.59e-18 4.544e-16
48 I KAPPAB KINASE NF KAPPAB SIGNALING 12 70 1.137e-17 1.102e-15
49 NEURON APOPTOTIC PROCESS 10 35 2.416e-17 2.294e-15
50 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 1036 2.98e-17 2.719e-15
51 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1036 2.98e-17 2.719e-15
52 REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 1618 3.54e-17 3.167e-15
53 CYTOKINE MEDIATED SIGNALING PATHWAY 20 452 4.555e-17 3.925e-15
54 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 11 55 4.491e-17 3.925e-15
55 CELLULAR RESPONSE TO CYTOKINE STIMULUS 22 606 5.914e-17 5.003e-15
56 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 14 144 7.23e-17 5.902e-15
57 ACTIVATION OF PROTEIN KINASE ACTIVITY 17 279 7.149e-17 5.902e-15
58 RESPONSE TO TUMOR NECROSIS FACTOR 16 233 9.739e-17 7.813e-15
59 PROTEOLYSIS 28 1208 1.307e-16 1.03e-14
60 TOLL LIKE RECEPTOR SIGNALING PATHWAY 12 85 1.35e-16 1.047e-14
61 REGULATION OF HYDROLASE ACTIVITY 29 1327 1.449e-16 1.105e-14
62 POSITIVE REGULATION OF KINASE ACTIVITY 20 482 1.573e-16 1.18e-14
63 POSITIVE REGULATION OF HYDROLASE ACTIVITY 25 905 1.645e-16 1.215e-14
64 RESPONSE TO ABIOTIC STIMULUS 26 1024 2.603e-16 1.876e-14
65 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 15 200 2.621e-16 1.876e-14
66 ACTIVATION OF INNATE IMMUNE RESPONSE 15 204 3.529e-16 2.488e-14
67 NEURON DEATH 10 47 6.594e-16 4.555e-14
68 CELLULAR RESPONSE TO ABIOTIC STIMULUS 16 263 6.657e-16 4.555e-14
69 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 10 50 1.297e-15 8.749e-14
70 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 23 799 1.517e-15 9.939e-14
71 RESPONSE TO ENDOGENOUS STIMULUS 29 1450 1.499e-15 9.939e-14
72 REGULATION OF PROTEIN MODIFICATION PROCESS 31 1710 1.579e-15 1.02e-13
73 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 12 109 3.014e-15 1.921e-13
74 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 15 246 5.75e-15 3.616e-13
75 POSITIVE REGULATION OF DEFENSE RESPONSE 17 364 5.96e-15 3.698e-13
76 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 12 118 8.011e-15 4.905e-13
77 RESPONSE TO BIOTIC STIMULUS 23 886 1.376e-14 8.314e-13
78 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 20 616 1.673e-14 9.979e-13
79 REGULATION OF RESPONSE TO STRESS 28 1468 1.849e-14 1.089e-12
80 PHOSPHORYLATION 26 1228 1.96e-14 1.14e-12
81 REGULATION OF NECROTIC CELL DEATH 8 26 2.213e-14 1.271e-12
82 NECROTIC CELL DEATH 8 28 4.379e-14 2.485e-12
83 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 10 71 5.506e-14 3.087e-12
84 REGULATION OF INNATE IMMUNE RESPONSE 16 357 7.863e-14 4.355e-12
85 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 8.472e-14 4.638e-12
86 CELLULAR RESPONSE TO NITROGEN COMPOUND 18 505 8.893e-14 4.812e-12
87 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 16 370 1.364e-13 7.295e-12
88 REGULATION OF NEURON DEATH 14 252 1.827e-13 9.662e-12
89 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 8 33 1.929e-13 9.865e-12
90 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 8 33 1.929e-13 9.865e-12
91 CELLULAR RESPONSE TO MECHANICAL STIMULUS 10 80 1.916e-13 9.865e-12
92 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 15 321 2.839e-13 1.436e-11
93 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 15 323 3.106e-13 1.554e-11
94 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 17 470 3.824e-13 1.893e-11
95 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 36 4.17e-13 2.043e-11
96 PROTEIN PHOSPHORYLATION 22 944 5.227e-13 2.533e-11
97 CELLULAR RESPONSE TO STRESS 27 1565 7.164e-13 3.436e-11
98 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 11 132 1.054e-12 5.004e-11
99 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 15 360 1.485e-12 6.978e-11
100 RESPONSE TO HORMONE 21 893 1.696e-12 7.89e-11
101 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 43 1.96e-12 9.031e-11
102 REGULATION OF MEMBRANE PERMEABILITY 9 70 2.539e-12 1.158e-10
103 RESPONSE TO EXTERNAL STIMULUS 28 1821 3.74e-12 1.689e-10
104 CELLULAR RESPONSE TO EXTERNAL STIMULUS 13 264 6.682e-12 2.99e-10
105 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 6.94e-12 3.047e-10
106 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 6.94e-12 3.047e-10
107 REGULATION OF DEFENSE RESPONSE 19 759 8.326e-12 3.621e-10
108 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 7 30 9.028e-12 3.889e-10
109 NIK NF KAPPAB SIGNALING 9 83 1.238e-11 5.285e-10
110 REGULATION OF CELL PROLIFERATION 25 1496 1.392e-11 5.887e-10
111 RESPONSE TO LIPID 20 888 1.416e-11 5.937e-10
112 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 12 228 2.142e-11 8.9e-10
113 RESPONSE TO BACTERIUM 16 528 2.96e-11 1.219e-09
114 MITOCHONDRIAL MEMBRANE ORGANIZATION 9 92 3.192e-11 1.303e-09
115 REGULATION OF CELLULAR PROTEIN LOCALIZATION 16 552 5.721e-11 2.315e-09
116 REGULATION OF NEURON APOPTOTIC PROCESS 11 192 6.327e-11 2.538e-09
117 FC EPSILON RECEPTOR SIGNALING PATHWAY 10 142 6.522e-11 2.594e-09
118 NECROPTOTIC PROCESS 6 21 7.687e-11 3.031e-09
119 POSITIVE REGULATION OF NEURON DEATH 8 67 8.251e-11 3.226e-09
120 REGULATION OF EXECUTION PHASE OF APOPTOSIS 6 24 1.891e-10 7.332e-09
121 REGULATION OF NECROPTOTIC PROCESS 5 11 2.064e-10 7.937e-09
122 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 15 514 2.264e-10 8.636e-09
123 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 7 47 2.661e-10 1.007e-08
124 REGULATION OF INTRACELLULAR TRANSPORT 16 621 3.226e-10 1.21e-08
125 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 3.614e-10 1.345e-08
126 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 121 3.832e-10 1.415e-08
127 HOMEOSTATIC PROCESS 22 1337 4.602e-10 1.686e-08
128 IMMUNE RESPONSE 20 1100 6.308e-10 2.291e-08
129 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 22 1360 6.35e-10 2.291e-08
130 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 53 6.415e-10 2.296e-08
131 EXECUTION PHASE OF APOPTOSIS 7 55 8.398e-10 2.983e-08
132 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 19 1008 1.033e-09 3.64e-08
133 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 32 1.245e-09 4.357e-08
134 T CELL APOPTOTIC PROCESS 5 15 1.327e-09 4.608e-08
135 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 10 195 1.471e-09 5.07e-08
136 RESPONSE TO ORGANIC CYCLIC COMPOUND 18 917 1.654e-09 5.658e-08
137 T CELL HOMEOSTASIS 6 34 1.838e-09 6.244e-08
138 POSITIVE REGULATION OF GENE EXPRESSION 24 1733 1.908e-09 6.432e-08
139 FC RECEPTOR SIGNALING PATHWAY 10 206 2.502e-09 8.377e-08
140 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 2.532e-09 8.415e-08
141 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 103 2.723e-09 8.923e-08
142 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 2.72e-09 8.923e-08
143 CELLULAR RESPONSE TO PEPTIDE 11 274 2.764e-09 8.993e-08
144 RESPONSE TO MECHANICAL STIMULUS 10 210 3.013e-09 9.735e-08
145 PROTEIN OLIGOMERIZATION 13 434 3.056e-09 9.805e-08
146 REGULATION OF CATABOLIC PROCESS 16 731 3.388e-09 1.08e-07
147 LYMPHOCYTE APOPTOTIC PROCESS 5 18 3.756e-09 1.189e-07
148 REGULATION OF MITOCHONDRION ORGANIZATION 10 218 4.319e-09 1.358e-07
149 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 12 365 4.686e-09 1.463e-07
150 INFLAMMATORY RESPONSE 13 454 5.243e-09 1.626e-07
151 RESPONSE TO AMINO ACID 8 112 5.312e-09 1.637e-07
152 LEUKOCYTE DIFFERENTIATION 11 292 5.366e-09 1.643e-07
153 CHEMICAL HOMEOSTASIS 17 874 5.891e-09 1.784e-07
154 CELLULAR RESPONSE TO HORMONE STIMULUS 14 552 5.903e-09 1.784e-07
155 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 9 167 6.682e-09 2.006e-07
156 PROTEIN COMPLEX BIOGENESIS 19 1132 6.965e-09 2.064e-07
157 PROTEIN COMPLEX ASSEMBLY 19 1132 6.965e-09 2.064e-07
158 CELLULAR GLUCOSE HOMEOSTASIS 7 75 7.773e-09 2.289e-07
159 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 6 43 8.13e-09 2.379e-07
160 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 9.182e-09 2.67e-07
161 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 6 44 9.388e-09 2.713e-07
162 RESPONSE TO INORGANIC SUBSTANCE 13 479 9.931e-09 2.852e-07
163 RESPONSE TO OXYGEN LEVELS 11 311 1.031e-08 2.944e-07
164 MITOCHONDRIAL TRANSPORT 9 177 1.111e-08 3.152e-07
165 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 22 1.142e-08 3.22e-07
166 IMMUNE SYSTEM DEVELOPMENT 14 582 1.153e-08 3.232e-07
167 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 6 46 1.239e-08 3.452e-07
168 REGULATION OF ORGANELLE ORGANIZATION 19 1178 1.329e-08 3.68e-07
169 REGULATION OF MAP KINASE ACTIVITY 11 319 1.34e-08 3.69e-07
170 RESPONSE TO PEPTIDE 12 404 1.451e-08 3.96e-07
171 LEUKOCYTE APOPTOTIC PROCESS 5 23 1.455e-08 3.96e-07
172 POSITIVE REGULATION OF TRANSPORT 17 936 1.625e-08 4.396e-07
173 REGULATION OF PROTEIN LOCALIZATION 17 950 2.021e-08 5.435e-07
174 LYMPHOCYTE HOMEOSTASIS 6 50 2.079e-08 5.559e-07
175 NEGATIVE REGULATION OF MOLECULAR FUNCTION 18 1079 2.092e-08 5.562e-07
176 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 258 2.156e-08 5.699e-07
177 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 2.285e-08 6.007e-07
178 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 51 2.349e-08 6.141e-07
179 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 52 2.649e-08 6.885e-07
180 RESPONSE TO OXIDATIVE STRESS 11 352 3.677e-08 9.505e-07
181 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 5 28 4.193e-08 1.072e-06
182 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 28 4.193e-08 1.072e-06
183 T CELL RECEPTOR SIGNALING PATHWAY 8 146 4.284e-08 1.089e-06
184 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 11 4.457e-08 1.127e-06
185 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 10 282 4.987e-08 1.254e-06
186 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 5 29 5.053e-08 1.264e-06
187 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 289 6.276e-08 1.562e-06
188 LEUKOCYTE HOMEOSTASIS 6 60 6.372e-08 1.577e-06
189 RESPONSE TO WOUNDING 13 563 6.632e-08 1.633e-06
190 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 6.667e-08 1.633e-06
191 RENAL SYSTEM PROCESS 7 102 6.713e-08 1.635e-06
192 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 220 7.278e-08 1.764e-06
193 CELL ACTIVATION 13 568 7.35e-08 1.772e-06
194 POSITIVE REGULATION OF PROTEIN IMPORT 7 104 7.679e-08 1.842e-06
195 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 32 8.499e-08 2.028e-06
196 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 4 13 9.605e-08 2.269e-06
197 RESPONSE TO COBALT ION 4 13 9.605e-08 2.269e-06
198 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 5 33 9.989e-08 2.347e-06
199 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 22 1805 1.121e-07 2.621e-06
200 RENAL WATER HOMEOSTASIS 5 34 1.168e-07 2.717e-06
201 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 9 233 1.188e-07 2.751e-06
202 MITOCHONDRION ORGANIZATION 13 594 1.233e-07 2.841e-06
203 RESPONSE TO CARBOHYDRATE 8 168 1.272e-07 2.915e-06
204 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 4 14 1.341e-07 3.059e-06
205 PROTEIN HETEROOLIGOMERIZATION 7 113 1.362e-07 3.091e-06
206 GLUCOSE HOMEOSTASIS 8 170 1.393e-07 3.131e-06
207 CARBOHYDRATE HOMEOSTASIS 8 170 1.393e-07 3.131e-06
208 RESPONSE TO INTERLEUKIN 1 7 115 1.536e-07 3.437e-06
209 RESPONSE TO TOXIC SUBSTANCE 9 241 1.583e-07 3.525e-06
210 PROTEIN COMPLEX SUBUNIT ORGANIZATION 20 1527 1.595e-07 3.533e-06
211 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 14 720 1.616e-07 3.563e-06
212 RESPONSE TO CORTICOSTEROID 8 176 1.819e-07 3.992e-06
213 MACROMOLECULAR COMPLEX ASSEMBLY 19 1398 2.004e-07 4.377e-06
214 CELLULAR RESPONSE TO GLUCAGON STIMULUS 5 38 2.084e-07 4.532e-06
215 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 6 74 2.269e-07 4.91e-06
216 RESPONSE TO METAL ION 10 333 2.343e-07 5.046e-06
217 LEUKOCYTE CELL CELL ADHESION 9 255 2.553e-07 5.475e-06
218 INOSITOL LIPID MEDIATED SIGNALING 7 124 2.575e-07 5.496e-06
219 REGULATION OF CELLULAR LOCALIZATION 18 1277 2.66e-07 5.651e-06
220 LYMPHOCYTE ACTIVATION 10 342 2.995e-07 6.333e-06
221 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 3.164e-07 6.601e-06
222 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 4 17 3.164e-07 6.601e-06
223 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 3.164e-07 6.601e-06
224 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 7 128 3.198e-07 6.643e-06
225 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 3.372e-07 6.974e-06
226 RESPONSE TO REACTIVE OXYGEN SPECIES 8 191 3.4e-07 7.001e-06
227 REGULATION OF NIK NF KAPPAB SIGNALING 5 42 3.494e-07 7.162e-06
228 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 3.681e-07 7.513e-06
229 JNK CASCADE 6 82 4.195e-07 8.524e-06
230 RESPONSE TO ALCOHOL 10 362 5.04e-07 1.02e-05
231 RESPONSE TO ALKALOID 7 137 5.076e-07 1.022e-05
232 REGULATION OF TRANSPORT 21 1804 5.159e-07 1.035e-05
233 POSITIVE REGULATION OF MAP KINASE ACTIVITY 8 207 6.264e-07 1.251e-05
234 CELLULAR RESPONSE TO INTERLEUKIN 1 6 88 6.387e-07 1.259e-05
235 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 12 573 6.377e-07 1.259e-05
236 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 88 6.387e-07 1.259e-05
237 POSITIVE REGULATION OF MAPK CASCADE 11 470 6.663e-07 1.303e-05
238 WOUND HEALING 11 470 6.663e-07 1.303e-05
239 LYMPHOCYTE DIFFERENTIATION 8 209 6.737e-07 1.312e-05
240 RESPONSE TO GLUCAGON 5 48 6.92e-07 1.342e-05
241 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 7.239e-07 1.398e-05
242 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 381 8.029e-07 1.544e-05
243 DEFENSE RESPONSE 17 1231 8.201e-07 1.57e-05
244 REGULATION OF CYTOPLASMIC TRANSPORT 11 481 8.361e-07 1.594e-05
245 RESPONSE TO GAMMA RADIATION 5 50 8.516e-07 1.617e-05
246 PEPTIDYL SERINE MODIFICATION 7 148 8.555e-07 1.618e-05
247 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 8.824e-07 1.662e-05
248 REGULATION OF CELL ACTIVATION 11 484 8.886e-07 1.667e-05
249 RESPONSE TO NICOTINE 5 51 9.416e-07 1.76e-05
250 POSITIVE REGULATION OF PROTEIN OLIGOMERIZATION 4 22 9.596e-07 1.786e-05
251 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 95 1.005e-06 1.863e-05
252 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 1.159e-06 2.139e-05
253 LIPID PHOSPHORYLATION 6 99 1.281e-06 2.357e-05
254 HEMOSTASIS 9 311 1.34e-06 2.455e-05
255 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 10 404 1.364e-06 2.488e-05
256 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 1004 1.57e-06 2.853e-05
257 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 1.626e-06 2.944e-05
258 APOPTOTIC MITOCHONDRIAL CHANGES 5 57 1.651e-06 2.978e-05
259 LEUKOCYTE ACTIVATION 10 414 1.699e-06 3.04e-05
260 REGULATION OF CELL ADHESION 12 629 1.693e-06 3.04e-05
261 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 5 58 1.802e-06 3.213e-05
262 REGULATION OF GLUCOSE IMPORT 5 60 2.137e-06 3.794e-05
263 NEGATIVE REGULATION OF NEURON DEATH 7 171 2.251e-06 3.982e-05
264 DNA CATABOLIC PROCESS 4 27 2.272e-06 4.005e-05
265 RESPONSE TO VIRUS 8 247 2.357e-06 4.139e-05
266 RESPONSE TO DRUG 10 431 2.434e-06 4.258e-05
267 REGULATION OF AUTOPHAGY 8 249 2.503e-06 4.361e-05
268 REGULATION OF MAPK CASCADE 12 660 2.785e-06 4.836e-05
269 REGULATION OF PROTEIN IMPORT 7 183 3.529e-06 6.105e-05
270 CELLULAR HOMEOSTASIS 12 676 3.563e-06 6.139e-05
271 REGULATION OF CYTOKINE PRODUCTION 11 563 3.836e-06 6.586e-05
272 AGING 8 264 3.859e-06 6.601e-05
273 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1087 4.171e-06 7.108e-05
274 SINGLE ORGANISM CELL ADHESION 10 459 4.256e-06 7.228e-05
275 CELLULAR CHEMICAL HOMEOSTASIS 11 570 4.316e-06 7.303e-05
276 MYELOID CELL DIFFERENTIATION 7 189 4.367e-06 7.362e-05
277 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 32 4.595e-06 7.686e-05
278 WATER HOMEOSTASIS 5 70 4.608e-06 7.686e-05
279 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 4 32 4.595e-06 7.686e-05
280 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 4.734e-06 7.866e-05
281 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 4.773e-06 7.904e-05
282 MULTICELLULAR ORGANISMAL HOMEOSTASIS 8 272 4.808e-06 7.932e-05
283 RESPONSE TO UV 6 126 5.23e-06 8.599e-05
284 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 5.786e-06 9.48e-05
285 CELLULAR RESPONSE TO ALKALOID 4 34 5.894e-06 9.623e-05
286 REGULATION OF LIPID METABOLIC PROCESS 8 282 6.266e-06 0.0001019
287 REGULATION OF PROTEIN OLIGOMERIZATION 4 35 6.637e-06 0.0001073
288 NEGATIVE REGULATION OF NECROTIC CELL DEATH 3 11 6.64e-06 0.0001073
289 B CELL ACTIVATION 6 132 6.839e-06 0.0001101
290 REGULATION OF CELL CELL ADHESION 9 380 6.869e-06 0.0001102
291 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 1152 8.416e-06 0.0001344
292 CELLULAR RESPONSE TO RADIATION 6 137 8.468e-06 0.0001344
293 REGULATION OF INFLAMMATORY RESPONSE 8 294 8.494e-06 0.0001344
294 ACTIVATION OF MAPK ACTIVITY 6 137 8.468e-06 0.0001344
295 RESPONSE TO STEROID HORMONE 10 497 8.556e-06 0.0001349
296 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 8.909e-06 0.00014
297 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 9.146e-06 0.0001433
298 REGULATION OF PROTEIN MATURATION 5 82 1.006e-05 0.000157
299 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 1.082e-05 0.0001684
300 REGULATION OF CELL DIFFERENTIATION 17 1492 1.103e-05 0.0001711
301 RESPONSE TO ESTROGEN 7 218 1.112e-05 0.0001713
302 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 1.112e-05 0.0001713
303 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 1.143e-05 0.0001747
304 HEPATOCYTE APOPTOTIC PROCESS 3 13 1.145e-05 0.0001747
305 POSITIVE REGULATION OF MACROPHAGE DIFFERENTIATION 3 13 1.145e-05 0.0001747
306 REGULATION OF HOMOTYPIC CELL CELL ADHESION 8 307 1.163e-05 0.0001763
307 REGULATION OF PROTEIN TARGETING 8 307 1.163e-05 0.0001763
308 RESPONSE TO IONIZING RADIATION 6 145 1.172e-05 0.0001764
309 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 145 1.172e-05 0.0001764
310 RESPONSE TO ESTRADIOL 6 146 1.219e-05 0.0001829
311 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 18 1672 1.245e-05 0.0001863
312 RESPONSE TO RADIATION 9 413 1.337e-05 0.0001994
313 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 1.393e-05 0.0002071
314 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 3 14 1.454e-05 0.0002154
315 EPITHELIAL CELL PROLIFERATION 5 89 1.501e-05 0.0002218
316 RESPONSE TO ACID CHEMICAL 8 319 1.534e-05 0.0002252
317 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 6 152 1.533e-05 0.0002252
318 REGULATION OF LEUKOCYTE DIFFERENTIATION 7 232 1.663e-05 0.0002434
319 APOPTOTIC DNA FRAGMENTATION 3 15 1.813e-05 0.0002644
320 NEGATIVE REGULATION OF CELL CYCLE 9 433 1.944e-05 0.0002826
321 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 1395 1.956e-05 0.0002835
322 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 5 96 2.169e-05 0.0003135
323 REGULATION OF CELL CYCLE 13 949 2.185e-05 0.0003146
324 RESPONSE TO ANTIBIOTIC 4 47 2.191e-05 0.0003146
325 POSITIVE REGULATION OF CELL CELL ADHESION 7 243 2.241e-05 0.0003208
326 CELLULAR RESPONSE TO BIOTIC STIMULUS 6 163 2.277e-05 0.000325
327 REGULATION OF LIPID KINASE ACTIVITY 4 48 2.383e-05 0.0003381
328 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 684 2.382e-05 0.0003381
329 REGULATION OF GLUCOSE TRANSPORT 5 100 2.643e-05 0.0003738
330 NEGATIVE REGULATION OF ANOIKIS 3 17 2.696e-05 0.0003801
331 POSITIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 50 2.806e-05 0.0003945
332 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 2.994e-05 0.0004196
333 POSITIVE REGULATION OF MITOCHONDRIAL MEMBRANE PERMEABILITY 3 18 3.227e-05 0.0004495
334 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 3.227e-05 0.0004495
335 GLYCEROLIPID METABOLIC PROCESS 8 356 3.363e-05 0.0004665
336 LEUKOCYTE MIGRATION 7 259 3.369e-05 0.0004665
337 HOMEOSTASIS OF NUMBER OF CELLS 6 175 3.396e-05 0.000469
338 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 3.501e-05 0.0004819
339 CELLULAR RESPONSE TO AMINO ACID STIMULUS 4 53 3.54e-05 0.0004859
340 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 4 54 3.813e-05 0.0005165
341 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 3.822e-05 0.0005165
342 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 4 54 3.813e-05 0.0005165
343 REGULATION OF CELL CYCLE ARREST 5 108 3.83e-05 0.0005165
344 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 5 108 3.83e-05 0.0005165
345 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 3 19 3.822e-05 0.0005165
346 PHOSPHOLIPID METABOLIC PROCESS 8 364 3.937e-05 0.0005294
347 RESPONSE TO HYDROGEN PEROXIDE 5 109 4.003e-05 0.0005368
348 RESPONSE TO KETONE 6 182 4.23e-05 0.0005656
349 REGULATION OF MYELOID CELL DIFFERENTIATION 6 183 4.362e-05 0.0005815
350 POSITIVE REGULATION OF CYTOKINE PRODUCTION 8 370 4.418e-05 0.0005874
351 POSITIVE REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 20 4.485e-05 0.0005929
352 REGULATION OF MACROPHAGE DIFFERENTIATION 3 20 4.485e-05 0.0005929
353 IMMUNE EFFECTOR PROCESS 9 486 4.789e-05 0.0006313
354 CELL CELL ADHESION 10 608 4.807e-05 0.0006318
355 B CELL HOMEOSTASIS 3 21 5.22e-05 0.0006822
356 RESPONSE TO NITRIC OXIDE 3 21 5.22e-05 0.0006822
357 PROTEIN DEPHOSPHORYLATION 6 190 5.376e-05 0.0007007
358 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 59 5.415e-05 0.0007039
359 PROTEIN AUTOPHOSPHORYLATION 6 192 5.698e-05 0.0007386
360 EMBRYO DEVELOPMENT 12 894 5.748e-05 0.0007429
361 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 5.851e-05 0.0007542
362 REGULATION OF MITOCHONDRIAL MEMBRANE PERMEABILITY INVOLVED IN APOPTOTIC PROCESS 3 22 6.029e-05 0.0007728
363 REGULATION OF PROTEIN HOMODIMERIZATION ACTIVITY 3 22 6.029e-05 0.0007728
364 MEMBRANE ORGANIZATION 12 899 6.064e-05 0.0007752
365 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 6.177e-05 0.0007874
366 REGULATION OF BODY FLUID LEVELS 9 506 6.533e-05 0.0008306
367 REGULATION OF B CELL ACTIVATION 5 121 6.594e-05 0.0008361
368 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 5 122 6.858e-05 0.0008671
369 T CELL DIFFERENTIATION 5 123 7.129e-05 0.0008989
370 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 8 397 7.241e-05 0.0009106
371 CELLULAR COMPONENT DISASSEMBLY 9 515 7.478e-05 0.0009378
372 NEGATIVE REGULATION OF CATABOLIC PROCESS 6 203 7.757e-05 0.0009703
373 REGULATION OF ANOIKIS 3 24 7.884e-05 0.0009834
374 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 126 7.993e-05 0.0009944
375 MACROMOLECULE CATABOLIC PROCESS 12 926 8.048e-05 0.0009986
376 CELLULAR RESPONSE TO UV 4 66 8.419e-05 0.001042
377 APOPTOTIC NUCLEAR CHANGES 3 25 8.936e-05 0.0011
378 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 8.936e-05 0.0011
379 LIPID MODIFICATION 6 210 9.35e-05 0.001148
380 REGULATION OF RESPONSE TO WOUNDING 8 413 9.529e-05 0.001167
381 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 131 9.609e-05 0.001174
382 INTERSPECIES INTERACTION BETWEEN ORGANISMS 10 662 9.754e-05 0.001185
383 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 10 662 9.754e-05 0.001185
384 CELL DEVELOPMENT 15 1426 0.0001003 0.001216
385 POSITIVE REGULATION OF CELL ACTIVATION 7 311 0.0001065 0.001287
386 CELL PROLIFERATION 10 672 0.0001103 0.00133
387 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 0.0001107 0.001331
388 REGULATION OF HEMOPOIESIS 7 314 0.000113 0.001356
389 POSITIVE REGULATION OF CELL PROLIFERATION 11 814 0.0001143 0.001368
390 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 138 0.0001228 0.001465
391 POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 3 28 0.0001263 0.0015
392 MODULATION BY SYMBIONT OF HOST CELLULAR PROCESS 3 28 0.0001263 0.0015
393 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 0.0001316 0.001558
394 REGULATION OF CELLULAR RESPONSE TO STRESS 10 691 0.0001386 0.001637
395 NEGATIVE REGULATION OF PROTEOLYSIS 7 329 0.0001508 0.001777
396 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 0.0001558 0.00183
397 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 0.00016 0.001875
398 REGULATION OF HOMEOSTATIC PROCESS 8 447 0.0001642 0.001919
399 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 147 0.0001651 0.001926
400 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 4 79 0.0001696 0.001973
401 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 0.0001718 0.001991
402 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 0.000172 0.001991
403 ESTABLISHMENT OF LOCALIZATION IN CELL 16 1676 0.0001755 0.002027
404 REGULATION OF DNA METABOLIC PROCESS 7 340 0.0001846 0.002126
405 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 4 81 0.0001868 0.002146
406 CELLULAR RESPONSE TO LIPID 8 457 0.0001909 0.002188
407 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 6 245 0.0002165 0.002475
408 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0002178 0.002484
409 GAMETE GENERATION 9 595 0.0002218 0.002524
410 POSITIVE REGULATION OF CELL CYCLE ARREST 4 85 0.000225 0.002553
411 PROTEIN KINASE B SIGNALING 3 34 0.0002273 0.002573
412 PROTEIN HOMOOLIGOMERIZATION 6 248 0.0002311 0.00261
413 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0002354 0.002652
414 NEGATIVE REGULATION OF PROTEIN PROCESSING 3 35 0.000248 0.002774
415 RESPONSE TO GROWTH FACTOR 8 475 0.000248 0.002774
416 NEGATIVE REGULATION OF PROTEIN MATURATION 3 35 0.000248 0.002774
417 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 88 0.0002571 0.002869
418 POSITIVE REGULATION OF HEMOPOIESIS 5 163 0.0002669 0.002971
419 B CELL DIFFERENTIATION 4 89 0.0002685 0.002981
420 CALCIUM MEDIATED SIGNALING 4 90 0.0002802 0.003105
421 CELLULAR RESPONSE TO LIGHT STIMULUS 4 91 0.0002923 0.00323
422 MODULATION BY VIRUS OF HOST MORPHOLOGY OR PHYSIOLOGY 3 37 0.0002929 0.00323
423 INNATE IMMUNE RESPONSE 9 619 0.000297 0.003267
424 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 5 168 0.0003069 0.003368
425 CELLULAR LIPID METABOLIC PROCESS 11 913 0.0003097 0.003391
426 MITOTIC CELL CYCLE 10 766 0.0003176 0.003469
427 REGULATION OF CELLULAR COMPONENT BIOGENESIS 10 767 0.0003209 0.003497
428 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 170 0.0003241 0.003523
429 POSITIVE REGULATION OF CELL ADHESION 7 376 0.0003402 0.003685
430 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 8 498 0.0003406 0.003685
431 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0003428 0.003693
432 SPLEEN DEVELOPMENT 3 39 0.0003428 0.003693
433 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 0.0003446 0.003703
434 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 0.0003493 0.003745
435 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 0.0003512 0.003757
436 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 0.0003586 0.003827
437 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0003697 0.003927
438 REGULATION OF ACTIVATED T CELL PROLIFERATION 3 40 0.0003697 0.003927
439 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 4 98 0.0003879 0.004112
440 MITOTIC SPINDLE ASSEMBLY 3 41 0.0003979 0.004198
441 MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS 3 41 0.0003979 0.004198
442 REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 4 101 0.000435 0.00458
443 RESPONSE TO LIGHT STIMULUS 6 280 0.0004417 0.00464
444 GLAND DEVELOPMENT 7 395 0.0004571 0.00479
445 CELLULAR RESPONSE TO OXIDATIVE STRESS 5 184 0.0004657 0.004869
446 DEPHOSPHORYLATION 6 286 0.0004941 0.005154
447 POSITIVE REGULATION OF INTERLEUKIN 8 PRODUCTION 3 45 0.0005244 0.005422
448 THYMOCYTE AGGREGATION 3 45 0.0005244 0.005422
449 MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY 3 45 0.0005244 0.005422
450 T CELL DIFFERENTIATION IN THYMUS 3 45 0.0005244 0.005422
451 LIPID BIOSYNTHETIC PROCESS 8 539 0.000575 0.005933
452 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 5 197 0.0006349 0.006536
453 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 9 689 0.0006454 0.00663
454 REGULATION OF CERAMIDE BIOSYNTHETIC PROCESS 2 11 0.0006507 0.006655
455 POSITIVE REGULATION OF HAIR CYCLE 2 11 0.0006507 0.006655
456 OVULATION CYCLE 4 113 0.0006648 0.006768
457 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 5 199 0.0006646 0.006768
458 REGULATION OF TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 49 0.0006741 0.006848
459 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 8 554 0.0006881 0.00696
460 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 4 114 0.0006871 0.00696
461 REGULATION OF IMMUNE EFFECTOR PROCESS 7 424 0.0006955 0.007019
462 REGULATION OF CELL CYCLE PROCESS 8 558 0.0007211 0.007263
463 FEMALE SEX DIFFERENTIATION 4 116 0.0007335 0.007371
464 RESPONSE TO INSULIN 5 205 0.0007598 0.007619
465 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 0.0007766 0.007713
466 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0007791 0.007713
467 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0007791 0.007713
468 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0007791 0.007713
469 REPLICATIVE SENESCENCE 2 12 0.0007791 0.007713
470 POSITIVE REGULATION OF EXECUTION PHASE OF APOPTOSIS 2 12 0.0007791 0.007713
471 HEAD DEVELOPMENT 9 709 0.0007911 0.007816
472 CELLULAR RESPONSE TO IONIZING RADIATION 3 52 0.0008025 0.007894
473 REGULATION OF T CELL MEDIATED IMMUNITY 3 52 0.0008025 0.007894
474 GLUCOSE METABOLIC PROCESS 4 119 0.000807 0.007922
475 GERM CELL DEVELOPMENT 5 209 0.0008287 0.008117
476 BIOLOGICAL ADHESION 11 1032 0.0008635 0.00844
477 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0008962 0.008724
478 B CELL RECEPTOR SIGNALING PATHWAY 3 54 0.0008962 0.008724
479 REGULATION OF ADAPTIVE IMMUNE RESPONSE 4 123 0.0009131 0.008814
480 REGULATION OF SPHINGOLIPID BIOSYNTHETIC PROCESS 2 13 0.0009187 0.008814
481 REGULATION OF MEMBRANE LIPID METABOLIC PROCESS 2 13 0.0009187 0.008814
482 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 2 13 0.0009187 0.008814
483 REGULATION OF PROTEIN POLYUBIQUITINATION 2 13 0.0009187 0.008814
484 PROTEIN AUTOPROCESSING 2 13 0.0009187 0.008814
485 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0009187 0.008814
486 NEGATIVE REGULATION OF CELL CYCLE PROCESS 5 214 0.0009212 0.00882
487 TUBE MORPHOGENESIS 6 323 0.0009323 0.008908
488 REGULATION OF B CELL PROLIFERATION 3 55 0.0009455 0.009016
489 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 5 216 0.0009603 0.009138
490 SEXUAL REPRODUCTION 9 730 0.0009721 0.009231
491 ORGANOPHOSPHATE METABOLIC PROCESS 10 885 0.0009756 0.009245
492 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 217 0.0009803 0.009271
493 POSITIVE REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 3 57 0.001049 0.009883
494 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 57 0.001049 0.009883
NumGOOverlapSizeP ValueAdj. P Value
1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 13 47 4.656e-22 4.325e-19
2 DEATH RECEPTOR BINDING 9 18 2.19e-18 1.017e-15
3 CYTOKINE RECEPTOR BINDING 16 271 1.068e-15 3.308e-13
4 ENZYME BINDING 30 1737 2.032e-14 4.719e-12
5 KINASE ACTIVITY 21 842 5.503e-13 1.022e-10
6 UBIQUITIN LIKE PROTEIN LIGASE BINDING 13 264 6.682e-12 9.566e-10
7 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 6 15 7.208e-12 9.566e-10
8 TUMOR NECROSIS FACTOR RECEPTOR BINDING 7 30 9.028e-12 1.048e-09
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 21 992 1.241e-11 1.281e-09
10 PROTEIN HETERODIMERIZATION ACTIVITY 15 468 6.135e-11 5.699e-09
11 PROTEASE BINDING 9 104 9.768e-11 8.249e-09
12 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 1.184e-10 9.17e-09
13 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 1.379e-10 9.851e-09
14 PROTEIN SERINE THREONINE KINASE ACTIVITY 14 445 3.691e-10 2.449e-08
15 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 4.845e-10 3e-08
16 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 8 86 6.369e-10 3.698e-08
17 PROTEIN KINASE ACTIVITY 15 640 4.536e-09 2.479e-07
18 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 6 42 7.015e-09 3.62e-07
19 KINASE REGULATOR ACTIVITY 9 186 1.711e-08 8.365e-07
20 KINASE BINDING 14 606 1.916e-08 8.477e-07
21 DEATH RECEPTOR ACTIVITY 5 24 1.833e-08 8.477e-07
22 ENZYME REGULATOR ACTIVITY 17 959 2.321e-08 9.799e-07
23 ADENYL NUCLEOTIDE BINDING 21 1514 2.638e-08 1.065e-06
24 PROTEIN DIMERIZATION ACTIVITY 18 1149 5.461e-08 2.114e-06
25 RECEPTOR BINDING 20 1476 9.162e-08 3.405e-06
26 MOLECULAR FUNCTION REGULATOR 19 1353 1.203e-07 4.139e-06
27 IDENTICAL PROTEIN BINDING 18 1209 1.177e-07 4.139e-06
28 PROTEIN PHOSPHATASE BINDING 7 120 2.058e-07 6.827e-06
29 PROTEIN DOMAIN SPECIFIC BINDING 13 624 2.172e-07 6.958e-06
30 CYSTEINE TYPE PEPTIDASE ACTIVITY 8 184 2.557e-07 7.918e-06
31 RIBONUCLEOTIDE BINDING 21 1860 8.536e-07 2.558e-05
32 PHOSPHATASE BINDING 7 162 1.569e-06 4.556e-05
33 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 30 3.52e-06 9.909e-05
34 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 6.64e-06 0.0001814
35 PEPTIDASE REGULATOR ACTIVITY 7 214 9.855e-06 0.0002616
36 PROTEIN KINASE A BINDING 4 42 1.393e-05 0.0003594
37 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 3 15 1.813e-05 0.0004551
38 PROTEIN COMPLEX BINDING 13 935 1.869e-05 0.0004568
39 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 2.225e-05 0.0005301
40 PEPTIDASE ACTIVATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 21 5.22e-05 0.001183
41 ENZYME INHIBITOR ACTIVITY 8 378 5.137e-05 0.001183
42 CAMP BINDING 3 23 6.915e-05 0.001494
43 CYSTEINE TYPE ENDOPEPTIDASE INHIBITOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 23 6.915e-05 0.001494
44 SIGNAL TRANSDUCER ACTIVITY 17 1731 7.388e-05 0.00154
45 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 7.461e-05 0.00154
46 MACROMOLECULAR COMPLEX BINDING 15 1399 8.093e-05 0.001634
47 ENDOPEPTIDASE ACTIVITY 8 448 0.0001667 0.003295
48 HEAT SHOCK PROTEIN BINDING 4 89 0.0002685 0.005014
49 KINASE INHIBITOR ACTIVITY 4 89 0.0002685 0.005014
50 CYCLIC NUCLEOTIDE BINDING 3 36 0.0002699 0.005014
51 PEPTIDASE ACTIVATOR ACTIVITY 3 38 0.0003173 0.005779
52 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 0.0004002 0.00715
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE MICRODOMAIN 18 288 4.928e-18 2.878e-15
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 237 3.309e-15 7.623e-13
3 CATALYTIC COMPLEX 25 1038 3.916e-15 7.623e-13
4 MEMBRANE PROTEIN COMPLEX 23 1020 2.661e-13 3.885e-11
5 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 3.534e-13 4.127e-11
6 TRANSFERASE COMPLEX 16 703 1.938e-09 1.887e-07
7 MEMBRANE REGION 19 1134 7.168e-09 5.981e-07
8 CILIARY BASE 5 23 1.455e-08 1.062e-06
9 PLASMA MEMBRANE PROTEIN COMPLEX 13 510 2.085e-08 1.353e-06
10 PROTEIN KINASE COMPLEX 7 90 2.807e-08 1.639e-06
11 CYTOSOLIC PART 9 223 8.172e-08 4.339e-06
12 MITOCHONDRION 20 1633 4.697e-07 2.286e-05
13 CD40 RECEPTOR COMPLEX 3 11 6.64e-06 0.0002983
14 RECEPTOR COMPLEX 8 327 1.834e-05 0.0007649
15 PHOSPHATASE COMPLEX 4 48 2.383e-05 0.0009279
16 EXTRINSIC COMPONENT OF MEMBRANE 7 252 2.829e-05 0.001032
17 OUTER MEMBRANE 6 190 5.376e-05 0.001847
18 MITOCHONDRIAL ENVELOPE 10 691 0.0001386 0.004497
19 PLASMA MEMBRANE RAFT 4 86 0.0002354 0.007234

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 70 89 1.297e-182 2.296e-180
2 hsa04650_Natural_killer_cell_mediated_cytotoxicity 21 136 1.773e-29 1.569e-27
3 hsa04620_Toll.like_receptor_signaling_pathway 19 102 2.432e-28 1.241e-26
4 hsa04722_Neurotrophin_signaling_pathway 20 127 2.964e-28 1.241e-26
5 hsa04380_Osteoclast_differentiation 20 128 3.504e-28 1.241e-26
6 hsa04660_T_cell_receptor_signaling_pathway 19 108 7.892e-28 2.328e-26
7 hsa04662_B_cell_receptor_signaling_pathway 17 75 5.521e-27 1.396e-25
8 hsa04010_MAPK_signaling_pathway 23 268 3.301e-26 7.305e-25
9 hsa04370_VEGF_signaling_pathway 16 76 7.403e-25 1.456e-23
10 hsa04910_Insulin_signaling_pathway 16 138 1.953e-20 3.457e-19
11 hsa04062_Chemokine_signaling_pathway 15 189 1.118e-16 1.799e-15
12 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 1.81e-16 2.67e-15
13 hsa04510_Focal_adhesion 15 200 2.621e-16 3.569e-15
14 hsa04115_p53_signaling_pathway 11 69 6.591e-16 8.332e-15
15 hsa04973_Carbohydrate_digestion_and_absorption 9 44 2.973e-14 3.508e-13
16 hsa04622_RIG.I.like_receptor_signaling_pathway 10 71 5.506e-14 6.091e-13
17 hsa04150_mTOR_signaling_pathway 9 52 1.509e-13 1.571e-12
18 hsa04664_Fc_epsilon_RI_signaling_pathway 10 79 1.681e-13 1.653e-12
19 hsa04012_ErbB_signaling_pathway 10 87 4.567e-13 4.254e-12
20 hsa04920_Adipocytokine_signaling_pathway 9 68 1.935e-12 1.712e-11
21 hsa04630_Jak.STAT_signaling_pathway 11 155 6.184e-12 5.212e-11
22 hsa04621_NOD.like_receptor_signaling_pathway 8 59 2.868e-11 2.307e-10
23 hsa04666_Fc_gamma_R.mediated_phagocytosis 9 95 4.282e-11 3.295e-10
24 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 1.157e-10 8.386e-10
25 hsa04720_Long.term_potentiation 8 70 1.184e-10 8.386e-10
26 hsa04310_Wnt_signaling_pathway 9 151 2.755e-09 1.875e-08
27 hsa04114_Oocyte_meiosis 8 114 6.115e-09 4.008e-08
28 hsa04070_Phosphatidylinositol_signaling_system 7 78 1.026e-08 6.487e-08
29 hsa04670_Leukocyte_transendothelial_migration 7 117 1.73e-07 1.056e-06
30 hsa04020_Calcium_signaling_pathway 8 177 1.9e-07 1.121e-06
31 hsa04810_Regulation_of_actin_cytoskeleton 7 214 9.855e-06 5.627e-05
32 hsa04623_Cytosolic_DNA.sensing_pathway 4 56 4.405e-05 0.0002437
33 hsa04360_Axon_guidance 5 130 9.267e-05 0.0004971
34 hsa04141_Protein_processing_in_endoplasmic_reticulum 5 168 0.0003069 0.001598
35 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.0004906 0.002481
36 hsa04742_Taste_transduction 3 52 0.0008025 0.003946
37 hsa04340_Hedgehog_signaling_pathway 3 56 0.0009966 0.004767
38 hsa00562_Inositol_phosphate_metabolism 3 57 0.001049 0.004888
39 hsa04976_Bile_secretion 3 71 0.001979 0.008983
40 hsa04971_Gastric_acid_secretion 3 74 0.002228 0.009859
41 hsa04970_Salivary_secretion 3 89 0.00376 0.01623
42 hsa04540_Gap_junction 3 90 0.00388 0.01635
43 hsa04912_GnRH_signaling_pathway 3 101 0.005356 0.02155
44 hsa04916_Melanogenesis 3 101 0.005356 0.02155
45 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.007848 0.03087
46 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.01281 0.0493
47 hsa04640_Hematopoietic_cell_lineage 2 88 0.03811 0.1435
48 hsa04110_Cell_cycle 2 128 0.07408 0.2732
49 hsa04530_Tight_junction 2 133 0.07913 0.2858
50 hsa04740_Olfactory_transduction 3 388 0.1547 0.5475

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

HCG11

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-122-5p;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-421;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-93-5p 14 AKT3 Sponge network -0.781 0 -0.659 0.00047 0.574
2

HCG11

 hsa-miR-103a-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-455-5p;hsa-miR-618 12 BCL2 Sponge network -0.781 0 -0.346 0.02497 0.56
3

DHRS4-AS1

 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-582-5p;hsa-miR-589-3p 10 PIK3R1 Sponge network -0.646 0.01829 -0.892 0 0.557
4

HCG11

 hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-192-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-224-3p;hsa-miR-301a-3p;hsa-miR-362-3p 11 ENDOD1 Sponge network -0.781 0 -0.999 0 0.544
5

DNM3OS

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-122-5p;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-32-3p;hsa-miR-502-3p;hsa-miR-616-5p;hsa-miR-93-5p 11 AKT3 Sponge network -2.094 1.0E-5 -0.659 0.00047 0.541
6

RP11-434D9.1

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-409-3p;hsa-miR-429;hsa-miR-629-3p 17 PIK3R1 Sponge network -2.913 0 -0.892 0 0.525
7

LINC00261

 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-589-3p;hsa-miR-629-3p 15 PIK3R1 Sponge network -1.194 0 -0.892 0 0.513
8 RP11-252E2.2 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -5.878 0 -0.892 0 0.505
9 RP4-539M6.20 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-218-5p;hsa-miR-324-3p;hsa-miR-495-3p 11 PIK3R1 Sponge network -1.177 0.00034 -0.892 0 0.493
10

RP11-513G11.3

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 14 PIK3R1 Sponge network -2.342 5.0E-5 -0.892 0 0.492
11

RP11-12A2.3

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-485-3p;hsa-miR-93-5p 18 PIK3R1 Sponge network -4.779 0 -0.892 0 0.489
12

LIPE-AS1

 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-589-3p;hsa-miR-654-3p;hsa-miR-93-5p 17 PIK3R1 Sponge network -0.323 0.03968 -0.892 0 0.488
13 AC004160.4 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 10 PIK3R1 Sponge network -6.232 0 -0.892 0 0.477
14

LINC01018

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-409-3p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p 20 PIK3R1 Sponge network -3.231 0 -0.892 0 0.472
15 AJ006998.2 hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-409-3p 10 PIK3R1 Sponge network 0.13 0.84524 -0.892 0 0.453
16

LDLRAD4-AS1

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-589-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -3.366 0 -0.892 0 0.45
17

RP11-166D19.1

 hsa-miR-103a-3p;hsa-miR-130b-5p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-32-3p;hsa-miR-33a-5p;hsa-miR-590-5p;hsa-miR-616-5p;hsa-miR-618 14 BCL2 Sponge network -0.244 0.28835 -0.346 0.02497 0.449
18

RP11-104J23.1

 hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p 10 PIK3R1 Sponge network -1.195 0.00749 -0.892 0 0.447
19 RP11-7M8.2 hsa-miR-106a-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-493-5p 11 PIK3R1 Sponge network -1.367 0.138 -0.892 0 0.444
20

AC005550.3

 hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-342-3p;hsa-miR-501-3p 13 PPP3R1 Sponge network -2.571 0.00132 -0.348 0 0.423
21

RP11-119D9.1

 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -2.765 0 -0.892 0 0.418
22 RP11-115C10.1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-429 11 PIK3R1 Sponge network -2.686 0.00069 -0.892 0 0.409
23 RP5-834N19.1 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -1.722 0.00283 -0.892 0 0.408
24

RP11-290F5.1

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-485-3p;hsa-miR-493-5p 17 PIK3R1 Sponge network -1.679 5.0E-5 -0.892 0 0.402
25 RP11-42O15.3 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-429 10 PIK3R1 Sponge network -1.562 0 -0.892 0 0.397
26

RP11-12A2.3

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-335-3p;hsa-miR-501-3p;hsa-miR-93-5p 15 PPP3R1 Sponge network -4.779 0 -0.348 0 0.397
27

RP11-119D9.1

 hsa-miR-106b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-24-3p;hsa-miR-27a-3p;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-501-3p;hsa-miR-93-5p;hsa-miR-940 16 PPP3R1 Sponge network -2.765 0 -0.348 0 0.395
28 TPRG1-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-409-3p;hsa-miR-629-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -0.756 0.03021 -0.892 0 0.394
29

DNM3OS

 hsa-miR-103a-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-20a-5p;hsa-miR-32-3p;hsa-miR-590-5p;hsa-miR-616-5p;hsa-miR-618 11 BCL2 Sponge network -2.094 1.0E-5 -0.346 0.02497 0.391
30

MIR22HG

 hsa-miR-103a-3p;hsa-miR-130b-5p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-32-3p;hsa-miR-590-5p;hsa-miR-618 10 BCL2 Sponge network -0.234 0.09523 -0.346 0.02497 0.382
31 RP11-115J16.1 hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200b-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-589-3p;hsa-miR-93-5p 14 PIK3R1 Sponge network -2.038 7.0E-5 -0.892 0 0.382
32

MAGI2-AS3

 hsa-miR-188-5p;hsa-miR-20a-3p;hsa-miR-224-3p;hsa-miR-25-3p;hsa-miR-324-5p;hsa-miR-421;hsa-miR-452-3p;hsa-miR-589-3p;hsa-miR-616-5p;hsa-miR-660-5p;hsa-miR-92a-3p 11 IRAK3 Sponge network -1.801 0 -1.135 0 0.377
33

RP11-545I5.3

 hsa-miR-127-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-409-3p;hsa-miR-485-3p;hsa-miR-493-5p;hsa-miR-495-3p;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-93-5p 13 PIK3R1 Sponge network 0.139 0.66524 -0.892 0 0.377
34

LINC00238

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-342-3p 13 PPP3R1 Sponge network -4.997 0 -0.348 0 0.375
35 CTD-2194A8.2 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-330-3p;hsa-miR-485-3p;hsa-miR-495-3p;hsa-miR-654-3p 12 PIK3R1 Sponge network -0.829 0.11289 -0.892 0 0.375
36

LINC00238

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 16 PIK3R1 Sponge network -4.997 0 -0.892 0 0.369
37

AC004862.6

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-335-3p;hsa-miR-93-5p 14 PPP3R1 Sponge network -2.202 0.00081 -0.348 0 0.365
38

MAGI2-AS3

 hsa-miR-106b-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-30d-5p;hsa-miR-589-3p;hsa-miR-616-5p;hsa-miR-93-3p;hsa-miR-93-5p 10 PPP3CA Sponge network -1.801 0 -0.536 0 0.362
39 RP11-473I1.9 hsa-miR-107;hsa-miR-122-5p;hsa-miR-146b-5p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-616-5p;hsa-miR-93-5p 12 AKT3 Sponge network -0.126 0.22247 -0.659 0.00047 0.36
40

AC004862.6

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p 17 PIK3R1 Sponge network -2.202 0.00081 -0.892 0 0.357
41

RP11-250B2.6

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -0.98 2.0E-5 -0.892 0 0.342
42

AP000473.5

 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-338-5p 12 PIK3R1 Sponge network -1.157 0.00884 -0.892 0 0.341
43 BDNF-AS hsa-miR-106a-5p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-369-3p;hsa-miR-409-3p;hsa-miR-495-3p;hsa-miR-629-3p 13 PIK3R1 Sponge network 0.214 0.16872 -0.892 0 0.338
44

RP11-250B2.6

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-93-5p 13 PPP3R1 Sponge network -0.98 2.0E-5 -0.348 0 0.333
45 RP11-736K20.5 hsa-miR-103a-3p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-185-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-409-3p;hsa-miR-485-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -0.26 0.20252 -0.892 0 0.33
46 RP11-963H4.3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -1.857 0.00116 -0.892 0 0.328
47

LIPE-AS1

 hsa-miR-106b-5p;hsa-miR-143-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 12 PPP3R1 Sponge network -0.323 0.03968 -0.348 0 0.327
48

RP11-407B7.1

 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-369-3p;hsa-miR-429;hsa-miR-493-5p;hsa-miR-582-5p;hsa-miR-629-3p;hsa-miR-93-5p 21 PIK3R1 Sponge network -0.818 0.00584 -0.892 0 0.324
49 LINC00864 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 11 PIK3R1 Sponge network -3.954 0 -0.892 0 0.322
50

MAGI2-AS3

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-421;hsa-miR-616-5p;hsa-miR-93-5p 10 AKT3 Sponge network -1.801 0 -0.659 0.00047 0.322
51 RP11-372E1.4 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-338-5p;hsa-miR-409-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -0.887 0.1067 -0.892 0 0.321
52

RP11-12A2.3

 hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-339-5p;hsa-miR-93-5p 12 PRKACB Sponge network -4.779 0 -0.44 6.0E-5 0.321
53

RP11-166D19.1

 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p 15 PIK3R1 Sponge network -0.244 0.28835 -0.892 0 0.32
54

LINC00261

 hsa-miR-106b-5p;hsa-miR-143-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-940 12 PPP3R1 Sponge network -1.194 0 -0.348 0 0.319
55

RP11-513G11.3

 hsa-miR-106b-5p;hsa-miR-143-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-93-5p 12 PPP3R1 Sponge network -2.342 5.0E-5 -0.348 0 0.318
56

LDLRAD4-AS1

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 11 PPP3R1 Sponge network -3.366 0 -0.348 0 0.311
57 RP13-650J16.1 hsa-miR-106b-5p;hsa-miR-127-5p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-495-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -0.901 0.04097 -0.892 0 0.311
58 RP11-1018N14.5 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-409-3p;hsa-miR-93-5p 10 PIK3R1 Sponge network -0.573 0.20573 -0.892 0 0.31
59

LINC01018

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-335-3p;hsa-miR-93-5p 13 PPP3R1 Sponge network -3.231 0 -0.348 0 0.309
60 RP11-736K20.6 hsa-miR-103a-3p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-485-3p;hsa-miR-629-3p 14 PIK3R1 Sponge network -0.197 0.37494 -0.892 0 0.305
61

MAGI2-AS3

 hsa-miR-130b-3p;hsa-miR-192-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-224-3p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-589-3p;hsa-miR-589-5p 11 ENDOD1 Sponge network -1.801 0 -0.999 0 0.301
62

RP11-166D19.1

 hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-192-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-301a-3p;hsa-miR-361-5p;hsa-miR-3613-5p;hsa-miR-589-3p;hsa-miR-589-5p 12 ENDOD1 Sponge network -0.244 0.28835 -0.999 0 0.301
63 LINC00885 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 10 PIK3R1 Sponge network -4.686 0 -0.892 0 0.3
64 RP11-43F13.3 hsa-miR-103a-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-204-5p;hsa-miR-20a-5p;hsa-miR-32-3p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-616-5p 12 BCL2 Sponge network -1.507 0.01021 -0.346 0.02497 0.295
65

MAGI2-AS3

 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -1.801 0 -0.892 0 0.294
66 RP11-538D16.2 hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-199b-5p;hsa-miR-200b-3p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-222-3p;hsa-miR-338-5p;hsa-miR-369-3p;hsa-miR-409-3p;hsa-miR-629-3p;hsa-miR-654-3p 15 PIK3R1 Sponge network 0.603 0.33218 -0.892 0 0.292
67

DHRS4-AS1

 hsa-miR-106b-5p;hsa-miR-140-3p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-589-3p 10 XIAP Sponge network -0.646 0.01829 -0.153 0.0753 0.292
68

RP11-166D19.1

 hsa-miR-16-1-3p;hsa-miR-188-5p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-33a-5p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-616-5p;hsa-miR-92a-3p 12 IRAK3 Sponge network -0.244 0.28835 -1.135 0 0.29
69 LINC00675 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p 10 PIK3R1 Sponge network -2.286 0.00023 -0.892 0 0.288
70

AP000473.5

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p 10 PPP3R1 Sponge network -1.157 0.00884 -0.348 0 0.283
71

AC005550.3

 hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 13 PIK3R1 Sponge network -2.571 0.00132 -0.892 0 0.281
72

RP11-7F17.3

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 13 PIK3R1 Sponge network -0.873 0.00204 -0.892 0 0.271
73

SMIM2-AS1

 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-127-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-199b-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-369-3p;hsa-miR-409-3p;hsa-miR-589-3p;hsa-miR-629-3p 21 PIK3R1 Sponge network -0.66 0.00587 -0.892 0 0.27
74

AC068138.1

 hsa-miR-143-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-20a-5p;hsa-miR-24-3p;hsa-miR-27a-3p;hsa-miR-335-3p 11 PPP3R1 Sponge network 2.041 0.0022 -0.348 0 0.27
75 RP11-143N13.2 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-485-3p;hsa-miR-495-3p;hsa-miR-654-3p 12 PIK3R1 Sponge network -1.036 0.08988 -0.892 0 0.269
76

RP11-104J23.1

 hsa-miR-143-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-24-3p;hsa-miR-27a-3p;hsa-miR-335-3p 11 PPP3R1 Sponge network -1.195 0.00749 -0.348 0 0.267
77

RP11-7F17.3

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-183-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-501-3p;hsa-miR-940 13 PPP3R1 Sponge network -0.873 0.00204 -0.348 0 0.263
78 RP4-594I10.3 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -2.333 0.00136 -0.892 0 0.253

Quest ID: 9c1c7397621ebf6b298eaabdf9e5c878