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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-20a-5p ABCA1 0.02 0.94502 0.12 0.63155 MirTarget; miRNATAP -0.24 0 NA
2 hsa-miR-20a-5p ABCA3 0.02 0.94502 -0.09 0.71876 miRNAWalker2 validate -0.16 0 NA
3 hsa-miR-20a-5p ABCD2 0.02 0.94502 -0.45 0.01817 MirTarget -0.2 0.00297 NA
4 hsa-miR-20a-5p ABHD2 0.02 0.94502 0.31 0.32233 miRNATAP -0.3 0 NA
5 hsa-miR-20a-5p ABHD5 0.02 0.94502 0.36 0.11787 MirTarget -0.1 0 NA
6 hsa-miR-20a-5p ACER3 0.02 0.94502 0.44 0.02509 mirMAP -0.13 1.0E-5 NA
7 hsa-miR-30d-5p ACTC1 0.11 0.82546 -0.22 0.31363 MirTarget; miRNATAP -0.27 0.00806 NA
8 hsa-miR-30d-5p ACTN1 0.11 0.82546 0.09 0.78189 miRNATAP -0.11 0.00058 NA
9 hsa-miR-30d-5p ACVR1 0.11 0.82546 0.1 0.65249 MirTarget; miRNATAP -0.21 0 NA
10 hsa-miR-20a-5p ACVR1B 0.02 0.94502 -0.17 0.45572 miRNATAP -0.13 0 NA
11 hsa-miR-30d-5p ADAM19 0.11 0.82546 0.58 0.00069 MirTarget; miRNATAP -0.42 0 NA
12 hsa-miR-20a-5p ADAM22 0.02 0.94502 -0.35 0.03223 MirTarget; mirMAP -0.41 0 NA
13 hsa-miR-30d-5p ADAMTS3 0.11 0.82546 -0.07 0.61975 miRNATAP -0.18 0.0074 NA
14 hsa-miR-20a-5p ADAMTS5 0.02 0.94502 -0.11 0.64807 miRNATAP -0.25 0 NA
15 hsa-miR-30d-5p ADAMTS6 0.11 0.82546 -0.14 0.20848 MirTarget; miRNATAP -0.45 0 NA
16 hsa-miR-30d-5p ADAMTS9 0.11 0.82546 -0.15 0.47467 miRNATAP -0.13 0.01679 NA
17 hsa-miR-30d-5p ADAP2 0.11 0.82546 0.01 0.95469 miRNAWalker2 validate -0.19 0 NA
18 hsa-miR-20a-5p ADCY1 0.02 0.94502 -0.53 0.0372 mirMAP -0.49 0 NA
19 hsa-miR-20a-5p ADCY9 0.02 0.94502 -0.32 0.16325 mirMAP -0.3 0 NA
20 hsa-miR-20a-5p ADRA2A 0.02 0.94502 -0.93 8.0E-5 miRNATAP -0.51 0 NA
21 hsa-miR-30d-5p ADRA2A 0.11 0.82546 -0.93 8.0E-5 MirTarget; miRNATAP -0.24 0.00134 NA
22 hsa-miR-30d-5p AFF2 0.11 0.82546 -0.15 0.30344 mirMAP -0.22 0.00382 NA
23 hsa-miR-20a-5p AFF4 0.02 0.94502 0.1 0.74149 miRNATAP -0.28 0 NA
24 hsa-miR-20a-5p AGA 0.02 0.94502 0.14 0.47698 MirTarget -0.12 0 NA
25 hsa-miR-20a-5p AGFG2 0.02 0.94502 -0.41 0.02454 miRNATAP -0.11 0 NA
26 hsa-miR-20a-5p AGPS 0.02 0.94502 0.49 0.04908 mirMAP -0.19 0 NA
27 hsa-miR-20a-5p AHNAK 0.02 0.94502 -0.28 0.54705 miRNATAP -0.4 0 NA
28 hsa-miR-30d-5p AIDA 0.11 0.82546 0.13 0.59154 MirTarget -0.11 0 NA
29 hsa-miR-20a-5p AKAP13 0.02 0.94502 0.02 0.95598 MirTarget; mirMAP; miRNATAP -0.14 0 NA
30 hsa-miR-20a-5p AKT3 0.02 0.94502 -0.08 0.72155 miRNATAP -0.14 0.00014 NA
31 hsa-miR-20a-5p ALDH1A3 0.02 0.94502 0.17 0.51186 mirMAP -0.12 0.01839 NA
32 hsa-miR-20a-5p ALDH3A2 0.02 0.94502 -0.13 0.63153 mirMAP -0.17 0 NA
33 hsa-miR-20a-5p ALPK3 0.02 0.94502 -0.06 0.72466 mirMAP -0.23 0 NA
34 hsa-miR-30d-5p ALPK3 0.11 0.82546 -0.06 0.72466 miRNATAP -0.18 0.00039 NA
35 hsa-miR-20a-5p ALX4 0.02 0.94502 -1.27 0 miRNATAP -0.17 0.01923 NA
36 hsa-miR-30d-5p AMMECR1 0.11 0.82546 0.53 0.00187 miRNATAP -0.12 0.00249 NA
37 hsa-miR-30d-5p AMOTL1 0.11 0.82546 -0.17 0.5134 MirTarget; miRNATAP -0.13 0.02152 NA
38 hsa-miR-20a-5p ANK2 0.02 0.94502 -0.71 0.00097 MirTarget; miRNATAP -0.27 0 NA
39 hsa-miR-20a-5p ANKRD12 0.02 0.94502 0.1 0.68323 MirTarget -0.21 0 NA
40 hsa-miR-20a-5p ANKRD29 0.02 0.94502 -1.02 0 MirTarget -0.3 0 NA
41 hsa-miR-20a-5p ANKRD50 0.02 0.94502 0.13 0.60536 MirTarget; miRNATAP -0.27 0 NA
42 hsa-miR-20a-5p ANO6 0.02 0.94502 0.09 0.76604 MirTarget -0.26 0 NA
43 hsa-miR-30d-5p ANTXR1 0.11 0.82546 0.34 0.2722 mirMAP -0.4 0 NA
44 hsa-miR-30d-5p ANTXR2 0.11 0.82546 -0.11 0.66549 mirMAP -0.26 0 NA
45 hsa-miR-30d-5p ANXA11 0.11 0.82546 -0.15 0.61377 mirMAP -0.13 0 NA
46 hsa-miR-20a-5p AP3S2 0.02 0.94502 0.13 0.61416 miRNAWalker2 validate; mirMAP -0.14 0 NA
47 hsa-miR-20a-5p APBB2 0.02 0.94502 -0.13 0.64936 MirTarget; miRNATAP -0.39 0 NA
48 hsa-miR-20a-5p AR 0.02 0.94502 -0.71 0.01216 mirMAP -1.27 0 NA
49 hsa-miR-30d-5p AR 0.11 0.82546 -0.71 0.01216 mirMAP -0.52 2.0E-5 27683042 Inhibition of endogenous miR-30b-3p and miR-30d-5p enhanced AR expression and androgen-independent cell growth; MiR-30d-5p levels were inversely correlated with AR activity as measured by PSA mRNA in metastatic CRPC
50 hsa-miR-30d-5p ARCN1 0.11 0.82546 0.42 0.18003 mirMAP -0.1 2.0E-5 NA
51 hsa-miR-30d-5p ARF4 0.11 0.82546 0.3 0.33656 MirTarget; miRNATAP -0.14 0 NA
52 hsa-miR-20a-5p ARFGEF2 0.02 0.94502 0.37 0.18628 miRNAWalker2 validate -0.17 0 NA
53 hsa-miR-20a-5p ARHGAP1 0.02 0.94502 -0.1 0.72274 MirTarget; miRNATAP -0.1 0 NA
54 hsa-miR-20a-5p ARHGAP12 0.02 0.94502 0.17 0.4478 miRNAWalker2 validate; miRNATAP -0.21 0 NA
55 hsa-miR-20a-5p ARHGAP24 0.02 0.94502 -0.35 0.04577 MirTarget -0.22 0 NA
56 hsa-miR-20a-5p ARHGAP26 0.02 0.94502 0.09 0.67346 MirTarget; mirMAP; miRNATAP -0.19 0 NA
57 hsa-miR-30d-5p ARHGAP26 0.11 0.82546 0.09 0.67346 MirTarget -0.19 8.0E-5 NA
58 hsa-miR-30d-5p ARHGAP28 0.11 0.82546 0.15 0.37632 mirMAP -0.36 0 NA
59 hsa-miR-20a-5p ARHGEF3 0.02 0.94502 -0.3 0.18309 MirTarget; miRNATAP -0.19 0 NA
60 hsa-miR-20a-5p ARHGEF38 0.02 0.94502 -0.62 0.00081 mirMAP -0.75 0 NA
61 hsa-miR-20a-5p ARID4A 0.02 0.94502 -0.08 0.70325 MirTarget; miRNATAP -0.23 0 NA
62 hsa-miR-20a-5p ARL13B 0.02 0.94502 0.1 0.52833 MirTarget -0.13 0 NA
63 hsa-miR-30d-5p ARL15 0.11 0.82546 -0.32 0.09697 MirTarget -0.29 0 NA
64 hsa-miR-20a-5p ARNT2 0.02 0.94502 -0.37 0.11922 mirMAP -0.23 0 NA
65 hsa-miR-30d-5p ARRDC4 0.11 0.82546 -0.16 0.46687 mirMAP -0.12 0.00578 NA
66 hsa-miR-20a-5p ARSB 0.02 0.94502 0.43 0.01303 mirMAP -0.12 0 NA
67 hsa-miR-20a-5p ARSD 0.02 0.94502 -0.12 0.66281 mirMAP -0.23 0 NA
68 hsa-miR-30d-5p ASCC3 0.11 0.82546 0.46 0.05204 MirTarget -0.17 0 NA
69 hsa-miR-20a-5p ASH1L 0.02 0.94502 0.1 0.71962 miRNATAP -0.18 0 NA
70 hsa-miR-20a-5p ASPA 0.02 0.94502 -1.02 0 mirMAP -0.49 0 NA
71 hsa-miR-20a-5p ATE1 0.02 0.94502 0.38 0.03232 MirTarget -0.3 0 NA
72 hsa-miR-20a-5p ATF6 0.02 0.94502 0.21 0.41477 mirMAP -0.11 0 NA
73 hsa-miR-20a-5p ATG16L1 0.02 0.94502 -0.27 0.19992 MirTarget; miRNATAP -0.14 0 NA
74 hsa-miR-20a-5p ATL3 0.02 0.94502 0.67 0.00106 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0 NA
75 hsa-miR-20a-5p ATP1A2 0.02 0.94502 -1.88 0 MirTarget; miRNATAP -0.73 0 NA
76 hsa-miR-30d-5p ATP6V1B2 0.11 0.82546 0.16 0.54639 MirTarget -0.15 0 NA
77 hsa-miR-30d-5p ATP7B 0.11 0.82546 -0.76 9.0E-5 mirMAP -0.15 0.01564 NA
78 hsa-miR-30d-5p ATP8B1 0.11 0.82546 -0.02 0.9455 miRNATAP -0.12 0.01198 NA
79 hsa-miR-20a-5p ATP8B2 0.02 0.94502 -0.44 0.0611 miRNAWalker2 validate -0.24 0 NA
80 hsa-miR-30d-5p ATP8B2 0.11 0.82546 -0.44 0.0611 miRNATAP -0.21 0 NA
81 hsa-miR-20a-5p ATRX 0.02 0.94502 0.21 0.45614 mirMAP -0.23 0 NA
82 hsa-miR-20a-5p ATXN1 0.02 0.94502 -0.15 0.51707 miRNATAP -0.26 0 NA
83 hsa-miR-30d-5p ATXN1 0.11 0.82546 -0.15 0.51707 mirMAP; miRNATAP -0.17 0 NA
84 hsa-miR-20a-5p ATXN1L 0.02 0.94502 0.37 0.14648 miRNATAP -0.12 0 NA
85 hsa-miR-20a-5p B3GALT2 0.02 0.94502 -0.46 0.00056 MirTarget -0.19 0 NA
86 hsa-miR-30d-5p B4GALT1 0.11 0.82546 0.23 0.47712 mirMAP -0.13 0.00019 NA
87 hsa-miR-30d-5p BACH1 0.11 0.82546 0.26 0.2497 miRNATAP -0.1 0.00376 NA
88 hsa-miR-30d-5p BACH2 0.11 0.82546 -0.33 0.04327 miRNATAP -0.14 0.026 NA
89 hsa-miR-20a-5p BBX 0.02 0.94502 0.2 0.4569 MirTarget; miRNATAP -0.17 0 NA
90 hsa-miR-20a-5p BCAS1 0.02 0.94502 -0.92 0.0007 mirMAP -1.02 0 NA
91 hsa-miR-20a-5p BCL2 0.02 0.94502 -0.49 0.08674 miRNAWalker2 validate; miRTarBase -0.4 0 27044389 We found that upregulated expression of miR-17 and miR-20a correlates with lack of pro-apoptotic Bim expression
92 hsa-miR-20a-5p BCL2L11 0.02 0.94502 0.05 0.80975 miRNATAP -0.11 0 27044389 We found that upregulated expression of miR-17 and miR-20a correlates with lack of pro-apoptotic Bim expression
93 hsa-miR-20a-5p BCL6 0.02 0.94502 -0.15 0.56483 miRNATAP -0.12 0 NA
94 hsa-miR-20a-5p BHLHE41 0.02 0.94502 -0.42 0.10013 miRNATAP -0.12 0.00097 NA
95 hsa-miR-20a-5p BMPR2 0.02 0.94502 0.07 0.81221 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.25 0 NA
96 hsa-miR-20a-5p BNC2 0.02 0.94502 -0.23 0.21926 miRNATAP -0.5 0 NA
97 hsa-miR-30d-5p BNC2 0.11 0.82546 -0.23 0.21926 mirMAP; miRNATAP -0.5 0 NA
98 hsa-miR-20a-5p BNIP3L 0.02 0.94502 -0.08 0.78998 MirTarget -0.24 0 NA
99 hsa-miR-30d-5p BNIP3L 0.11 0.82546 -0.08 0.78998 MirTarget; miRNATAP -0.18 0 NA
100 hsa-miR-20a-5p BTBD7 0.02 0.94502 -0.01 0.97477 MirTarget; miRNATAP -0.2 0 NA
101 hsa-miR-20a-5p BTG2 0.02 0.94502 -1.38 3.0E-5 miRNATAP -0.35 0 NA
102 hsa-miR-20a-5p C14orf28 0.02 0.94502 -0.26 0.02466 miRNATAP -0.17 0 NA
103 hsa-miR-20a-5p C16orf52 0.02 0.94502 -0.09 0.62126 miRNATAP -0.14 0 NA
104 hsa-miR-20a-5p C2CD2 0.02 0.94502 -0.22 0.35105 MirTarget; miRNATAP -0.11 0.00018 NA
105 hsa-miR-20a-5p C3orf70 0.02 0.94502 0.13 0.36578 miRNATAP -0.18 0 NA
106 hsa-miR-20a-5p C5orf24 0.02 0.94502 0.11 0.66503 mirMAP -0.17 0 NA
107 hsa-miR-20a-5p C5orf51 0.02 0.94502 0.33 0.14181 mirMAP -0.1 0 NA
108 hsa-miR-20a-5p C6orf120 0.02 0.94502 -0.06 0.79521 mirMAP -0.16 0 NA
109 hsa-miR-20a-5p C9orf47 0.02 0.94502 -0.51 2.0E-5 mirMAP -0.3 0 NA
110 hsa-miR-20a-5p C9orf66 0.02 0.94502 -0.56 0 mirMAP -0.18 0 NA
111 hsa-miR-20a-5p CA5B 0.02 0.94502 -0.12 0.49167 mirMAP -0.19 0 NA
112 hsa-miR-30d-5p CACNA1C 0.11 0.82546 -0.53 0.0051 mirMAP -0.14 0.00713 NA
113 hsa-miR-20a-5p CADM2 0.02 0.94502 -0.49 0.02007 MirTarget; miRNATAP -0.45 0 NA
114 hsa-miR-30d-5p CADPS 0.11 0.82546 -0.33 0.07102 miRNATAP -0.34 3.0E-5 NA
115 hsa-miR-20a-5p CALD1 0.02 0.94502 0.21 0.54601 miRNATAP -0.13 0 NA
116 hsa-miR-20a-5p CALN1 0.02 0.94502 -1.5 0 mirMAP -0.43 0 NA
117 hsa-miR-30d-5p CALN1 0.11 0.82546 -1.5 0 mirMAP -0.24 0.02307 NA
118 hsa-miR-30d-5p CALU 0.11 0.82546 0.62 0.04505 MirTarget -0.18 0 NA
119 hsa-miR-30d-5p CAMK2A 0.11 0.82546 -0.02 0.87803 mirMAP -0.5 0 NA
120 hsa-miR-20a-5p CAMK2N1 0.02 0.94502 -0.52 0.03614 miRNATAP -0.33 0 NA
121 hsa-miR-30d-5p CAMK4 0.11 0.82546 -0.13 0.31898 MirTarget; mirMAP -0.28 2.0E-5 NA
122 hsa-miR-30d-5p CAPN5 0.11 0.82546 -0.33 0.0409 MirTarget; miRNATAP -0.13 0.00503 NA
123 hsa-miR-30d-5p CAPZA1 0.11 0.82546 0.38 0.18619 MirTarget; miRNATAP -0.12 0 NA
124 hsa-miR-20a-5p CASC4 0.02 0.94502 0.09 0.74348 MirTarget -0.27 0 NA
125 hsa-miR-20a-5p CASP8 0.02 0.94502 0.1 0.62135 MirTarget -0.12 0 NA
126 hsa-miR-20a-5p CAV1 0.02 0.94502 -0.64 0.05014 miRNATAP -0.31 0 NA
127 hsa-miR-20a-5p CAV2 0.02 0.94502 -0.3 0.25751 mirMAP -0.12 0.00327 NA
128 hsa-miR-30d-5p CBLB 0.11 0.82546 0.18 0.34561 MirTarget; mirMAP -0.11 1.0E-5 NA
129 hsa-miR-20a-5p CBLN4 0.02 0.94502 -1.31 0 miRNATAP -0.72 0 NA
130 hsa-miR-20a-5p CBX7 0.02 0.94502 -0.92 0.0002 mirMAP -0.18 0 NA
131 hsa-miR-20a-5p CCBE1 0.02 0.94502 -0.18 0.24299 mirMAP -0.26 0 NA
132 hsa-miR-20a-5p CCDC103 0.02 0.94502 -0.34 0.01894 mirMAP -0.23 0 NA
133 hsa-miR-20a-5p CCDC125 0.02 0.94502 -0.33 0.08478 mirMAP -0.3 0 NA
134 hsa-miR-20a-5p CCND1 0.02 0.94502 -0.14 0.69562 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.22 0 NA
135 hsa-miR-20a-5p CCND2 0.02 0.94502 -0.14 0.53369 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 0 NA
136 hsa-miR-20a-5p CCNG2 0.02 0.94502 -0.38 0.1693 MirTarget; miRNATAP -0.26 0 NA
137 hsa-miR-30d-5p CCNJL 0.11 0.82546 0.09 0.52275 miRNATAP -0.3 0 NA
138 hsa-miR-20a-5p CCNT2 0.02 0.94502 0.11 0.62342 miRNATAP -0.13 0 NA
139 hsa-miR-20a-5p CD274 0.02 0.94502 0.3 0.01527 MirTarget; miRNATAP -0.13 0.00251 NA
140 hsa-miR-20a-5p CD69 0.02 0.94502 -0.81 0 miRNATAP -0.11 0.01727 NA
141 hsa-miR-30d-5p CDH13 0.11 0.82546 0.15 0.45179 miRNATAP -0.21 0 NA
142 hsa-miR-20a-5p CDHR3 0.02 0.94502 -0.22 0.24837 mirMAP -0.28 0 NA
143 hsa-miR-20a-5p CDKN1A 0.02 0.94502 -0.08 0.76832 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 2.0E-5 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex
144 hsa-miR-20a-5p CELF2 0.02 0.94502 -0.3 0.21413 miRNATAP -0.14 0.00019 NA
145 hsa-miR-30d-5p CELF2 0.11 0.82546 -0.3 0.21413 mirMAP; miRNATAP -0.13 0.02083 NA
146 hsa-miR-20a-5p CEP120 0.02 0.94502 -0.13 0.53966 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0 NA
147 hsa-miR-20a-5p CEP97 0.02 0.94502 0.49 0.00109 MirTarget; miRNATAP -0.2 0 NA
148 hsa-miR-20a-5p CHD9 0.02 0.94502 0.27 0.29488 MirTarget; miRNATAP -0.25 0 NA
149 hsa-miR-30d-5p CHL1 0.11 0.82546 -1.1 1.0E-5 MirTarget; miRNATAP -0.44 5.0E-5 NA
150 hsa-miR-30d-5p CHST1 0.11 0.82546 -0.04 0.83412 MirTarget -0.17 0.02702 NA
NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 140 1518 1.321e-17 6.144e-14
2 CELL DEVELOPMENT 131 1426 2.414e-16 5.617e-13
3 EPITHELIUM DEVELOPMENT 93 945 1.69e-13 2.562e-10
4 REGULATION OF CELL DIFFERENTIATION 127 1492 2.202e-13 2.562e-10
5 POSITIVE REGULATION OF GENE EXPRESSION 141 1733 2.782e-13 2.589e-10
6 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 143 1784 5.764e-13 4.47e-10
7 INTRACELLULAR SIGNAL TRANSDUCTION 130 1572 8.877e-13 5.901e-10
8 CARDIOVASCULAR SYSTEM DEVELOPMENT 80 788 1.958e-12 1.012e-09
9 CIRCULATORY SYSTEM DEVELOPMENT 80 788 1.958e-12 1.012e-09
10 TUBE DEVELOPMENT 63 552 3.561e-12 1.657e-09
11 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 141 1805 5.912e-12 2.293e-09
12 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 93 1004 5.485e-12 2.293e-09
13 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 133 1672 7.515e-12 2.69e-09
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 101 1142 9.63e-12 3.201e-09
15 RESPONSE TO ENDOGENOUS STIMULUS 118 1450 3.327e-11 1.032e-08
16 HEART DEVELOPMENT 54 466 7.364e-11 2.141e-08
17 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 86 957 1.74e-10 4.497e-08
18 NEUROGENESIS 113 1402 1.653e-10 4.497e-08
19 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 56 513 3.236e-10 7.925e-08
20 REGULATION OF CELLULAR COMPONENT MOVEMENT 73 771 4.7e-10 1.093e-07
21 POSITIVE REGULATION OF CELL DIFFERENTIATION 76 823 6.355e-10 1.408e-07
22 POSITIVE REGULATION OF MOLECULAR FUNCTION 133 1791 7.819e-10 1.654e-07
23 MORPHOGENESIS OF A BRANCHING STRUCTURE 28 167 9.464e-10 1.915e-07
24 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 109 1395 2.122e-09 4.115e-07
25 EMBRYONIC MORPHOGENESIS 55 539 5.39e-09 1.003e-06
26 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 122 1656 7.08e-09 1.267e-06
27 POSITIVE REGULATION OF CATALYTIC ACTIVITY 114 1518 8.275e-09 1.426e-06
28 ORGAN MORPHOGENESIS 74 841 8.739e-09 1.452e-06
29 TISSUE MORPHOGENESIS 54 533 9.539e-09 1.531e-06
30 TUBE MORPHOGENESIS 39 323 1.059e-08 1.643e-06
31 EPITHELIAL CELL DEVELOPMENT 28 186 1.132e-08 1.698e-06
32 REGULATION OF CELL DEVELOPMENT 73 836 1.522e-08 2.213e-06
33 CENTRAL NERVOUS SYSTEM DEVELOPMENT 75 872 1.811e-08 2.553e-06
34 POSITIVE REGULATION OF CELL DEVELOPMENT 49 472 2.162e-08 2.958e-06
35 RESPONSE TO HORMONE 76 893 2.261e-08 2.961e-06
36 REGULATION OF PHOSPHORUS METABOLIC PROCESS 118 1618 2.291e-08 2.961e-06
37 EMBRYO DEVELOPMENT 76 894 2.37e-08 2.981e-06
38 PEPTIDYL SERINE MODIFICATION 24 148 2.902e-08 3.553e-06
39 ACTIN FILAMENT BASED PROCESS 47 450 3.492e-08 4.167e-06
40 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 83 1021 3.831e-08 4.456e-06
41 UROGENITAL SYSTEM DEVELOPMENT 36 299 4.188e-08 4.753e-06
42 REGULATION OF PROTEIN MODIFICATION PROCESS 122 1710 4.427e-08 4.904e-06
43 VASCULATURE DEVELOPMENT 48 469 4.694e-08 5.079e-06
44 NEURON DIFFERENTIATION 73 874 9.219e-08 9.749e-06
45 BLOOD VESSEL MORPHOGENESIS 40 364 9.471e-08 9.793e-06
46 PROTEIN PHOSPHORYLATION 77 944 1.07e-07 1.082e-05
47 REGULATION OF GTPASE ACTIVITY 60 673 1.502e-07 1.487e-05
48 MORPHOGENESIS OF AN EPITHELIUM 42 400 1.618e-07 1.569e-05
49 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 64 740 1.725e-07 1.638e-05
50 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 134 1977 1.786e-07 1.662e-05
51 HEAD DEVELOPMENT 62 709 1.837e-07 1.676e-05
52 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 33 278 2.133e-07 1.908e-05
53 REGULATION OF HYDROLASE ACTIVITY 98 1327 2.296e-07 2.016e-05
54 EPITHELIAL CELL DIFFERENTIATION 48 495 2.407e-07 2.074e-05
55 CELLULAR COMPONENT MORPHOGENESIS 73 900 2.895e-07 2.449e-05
56 ENDOTHELIUM DEVELOPMENT 17 90 3.224e-07 2.679e-05
57 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 60 689 3.356e-07 2.74e-05
58 SINGLE ORGANISM BEHAVIOR 40 384 3.923e-07 3.148e-05
59 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 106 1492 4.676e-07 3.688e-05
60 REGULATION OF NEURON DIFFERENTIATION 51 554 5.027e-07 3.898e-05
61 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 107 1517 5.805e-07 4.428e-05
62 POSITIVE REGULATION OF LOCOMOTION 42 420 6.061e-07 4.549e-05
63 POSITIVE REGULATION OF NEURON DIFFERENTIATION 34 306 6.687e-07 4.939e-05
64 POSITIVE REGULATION OF HYDROLASE ACTIVITY 72 905 7.234e-07 5.232e-05
65 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 78 1008 7.309e-07 5.232e-05
66 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 124 1848 9.405e-07 6.63e-05
67 RHYTHMIC PROCESS 33 298 1.05e-06 7.29e-05
68 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 20 131 1.099e-06 7.52e-05
69 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 50 554 1.164e-06 7.85e-05
70 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 62 750 1.255e-06 8.343e-05
71 NEGATIVE REGULATION OF GENE EXPRESSION 104 1493 1.512e-06 9.907e-05
72 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 60 724 1.725e-06 0.0001115
73 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 24 184 1.806e-06 0.0001151
74 REGULATION OF KINASE ACTIVITY 63 776 1.882e-06 0.0001174
75 BEHAVIOR 47 516 1.893e-06 0.0001174
76 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 78 1036 2.089e-06 0.0001262
77 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 78 1036 2.089e-06 0.0001262
78 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 36 352 2.281e-06 0.0001361
79 REGULATION OF CELL DEATH 102 1472 2.434e-06 0.0001434
80 RESPONSE TO OXYGEN CONTAINING COMPOUND 97 1381 2.475e-06 0.0001439
81 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 91 1275 2.712e-06 0.0001558
82 VENTRICULAR SEPTUM DEVELOPMENT 12 54 2.933e-06 0.0001665
83 NEURON DEVELOPMENT 57 687 3.033e-06 0.0001686
84 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 83 1135 3.044e-06 0.0001686
85 BIOLOGICAL ADHESION 77 1032 3.403e-06 0.0001863
86 RESPONSE TO NITROGEN COMPOUND 67 859 3.501e-06 0.0001887
87 PEPTIDYL THREONINE MODIFICATION 11 46 3.528e-06 0.0001887
88 CARDIAC SEPTUM DEVELOPMENT 15 85 3.852e-06 0.0002014
89 HEART PROCESS 15 85 3.852e-06 0.0002014
90 RESPONSE TO MECHANICAL STIMULUS 25 210 5.882e-06 0.0003041
91 REGULATION OF TRANSPORT 118 1804 6.095e-06 0.0003082
92 PHOSPHORYLATION 87 1228 6.092e-06 0.0003082
93 PROTEIN LOCALIZATION 118 1805 6.255e-06 0.0003129
94 REGULATION OF JNK CASCADE 21 159 6.451e-06 0.0003193
95 PEPTIDYL AMINO ACID MODIFICATION 65 841 6.611e-06 0.0003238
96 RESPONSE TO STEROID HORMONE 44 497 8.307e-06 0.0004026
97 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 40 437 9.763e-06 0.0004645
98 EMBRYONIC ORGAN DEVELOPMENT 38 406 9.783e-06 0.0004645
99 MUSCLE TISSUE DEVELOPMENT 29 275 1.207e-05 0.0005618
100 ACTIN FILAMENT BASED MOVEMENT 15 93 1.207e-05 0.0005618
101 ENDOTHELIAL CELL DIFFERENTIATION 13 72 1.304e-05 0.0006008
102 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 6 14 1.55e-05 0.0007072
103 RESPONSE TO ORGANIC CYCLIC COMPOUND 68 917 1.58e-05 0.0007137
104 NEGATIVE REGULATION OF CELL DIFFERENTIATION 50 609 1.627e-05 0.0007279
105 REGULATION OF MAPK CASCADE 53 660 1.685e-05 0.0007328
106 APPENDAGE DEVELOPMENT 21 169 1.673e-05 0.0007328
107 LIMB DEVELOPMENT 21 169 1.673e-05 0.0007328
108 MUSCLE STRUCTURE DEVELOPMENT 39 432 1.725e-05 0.0007432
109 NEURON PROJECTION DEVELOPMENT 46 545 1.776e-05 0.0007583
110 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 61 799 1.847e-05 0.0007813
111 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 41 470 2.367e-05 0.0009924
112 REGULATION OF CELL SUBSTRATE ADHESION 21 173 2.391e-05 0.0009934
113 REGULATION OF CELL MORPHOGENESIS 46 552 2.444e-05 0.001006
114 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 49 602 2.471e-05 0.001009
115 REGULATION OF NEURON PROJECTION DEVELOPMENT 37 408 2.555e-05 0.001034
116 LENS DEVELOPMENT IN CAMERA TYPE EYE 12 66 2.596e-05 0.001041
117 DIGESTIVE SYSTEM DEVELOPMENT 19 148 2.633e-05 0.001047
118 CELLULAR RESPONSE TO NITROGEN COMPOUND 43 505 2.694e-05 0.001062
119 LOCOMOTION 78 1114 2.833e-05 0.001108
120 HOMEOSTATIC PROCESS 90 1337 3.011e-05 0.001162
121 RESPONSE TO GROWTH FACTOR 41 475 3.022e-05 0.001162
122 REGULATION OF DEVELOPMENTAL GROWTH 29 289 3.071e-05 0.001171
123 REGULATION OF CELL PROJECTION ORGANIZATION 46 558 3.193e-05 0.001194
124 MESENCHYME DEVELOPMENT 22 190 3.233e-05 0.001194
125 CELL PROJECTION ORGANIZATION 66 902 3.19e-05 0.001194
126 CELLULAR RESPONSE TO STRESS 102 1565 3.219e-05 0.001194
127 CIRCULATORY SYSTEM PROCESS 34 366 3.308e-05 0.001212
128 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 32 337 3.655e-05 0.001321
129 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 9 39 3.719e-05 0.001321
130 REGULATION OF AXON GUIDANCE 9 39 3.719e-05 0.001321
131 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 34 368 3.695e-05 0.001321
132 REGULATION OF DEVELOPMENTAL PIGMENTATION 6 16 3.833e-05 0.001351
133 REGULATION OF TRANSFERASE ACTIVITY 68 946 4.212e-05 0.00143
134 REGULATION OF CIRCADIAN RHYTHM 15 103 4.198e-05 0.00143
135 EMBRYONIC ORGAN MORPHOGENESIS 28 279 4.174e-05 0.00143
136 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 42 498 4.156e-05 0.00143
137 DEVELOPMENTAL MATURATION 22 193 4.115e-05 0.00143
138 NEURON PROJECTION MORPHOGENESIS 36 402 4.262e-05 0.001437
139 RESPONSE TO OXYGEN LEVELS 30 311 4.739e-05 0.001586
140 REGULATION OF ACTIN FILAMENT BASED PROCESS 30 312 5.029e-05 0.001665
141 CELLULAR RESPONSE TO HORMONE STIMULUS 45 552 5.07e-05 0.001665
142 RESPONSE TO ABIOTIC STIMULUS 72 1024 5.08e-05 0.001665
143 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 11 60 5.173e-05 0.001683
144 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 22 197 5.623e-05 0.001814
145 POSITIVE REGULATION OF CELL DEATH 48 605 5.653e-05 0.001814
146 REGULATION OF CELLULAR RESPONSE TO STRESS 53 691 5.771e-05 0.001839
147 ACTION POTENTIAL 14 94 5.833e-05 0.001846
148 POSITIVE REGULATION OF CELL COMMUNICATION 99 1532 5.898e-05 0.001854
149 ESTABLISHMENT OF PROTEIN LOCALIZATION 93 1423 6.66e-05 0.00208
150 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 59 801 6.976e-05 0.002153
151 SENSORY ORGAN DEVELOPMENT 41 493 6.986e-05 0.002153
152 POSITIVE REGULATION OF OSSIFICATION 13 84 7.088e-05 0.00217
153 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 24 229 7.333e-05 0.00223
154 ACTIVATION OF MAPKK ACTIVITY 10 52 7.392e-05 0.002233
155 CHEMICAL HOMEOSTASIS 63 874 7.45e-05 0.002236
156 WNT SIGNALING PATHWAY 32 351 7.982e-05 0.002381
157 RESPONSE TO DRUG 37 431 8.151e-05 0.002416
158 GLAND MORPHOGENESIS 14 97 8.289e-05 0.002441
159 MYELOID CELL DIFFERENTIATION 21 189 8.851e-05 0.00259
160 POSITIVE REGULATION OF KINASE ACTIVITY 40 482 8.932e-05 0.002598
161 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 24 232 9e-05 0.002601
162 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 162 9.194e-05 0.002641
163 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 14 98 9.287e-05 0.002651
164 MULTICELLULAR ORGANISMAL SIGNALING 16 123 9.528e-05 0.002677
165 STEM CELL DIFFERENTIATION 21 190 9.549e-05 0.002677
166 PATTERN SPECIFICATION PROCESS 36 418 9.488e-05 0.002677
167 ANGIOGENESIS 28 293 9.845e-05 0.002727
168 EMBRYONIC CAMERA TYPE EYE FORMATION 5 12 9.81e-05 0.002727
169 CIRCADIAN RHYTHM 17 137 0.0001057 0.002911
170 POSITIVE REGULATION OF RESPONSE TO STIMULUS 118 1929 0.0001164 0.003185
171 COGNITION 25 251 0.0001192 0.003224
172 OSSIFICATION 25 251 0.0001192 0.003224
173 VESICLE MEDIATED TRANSPORT 82 1239 0.0001215 0.003269
174 ENDOCHONDRAL BONE MORPHOGENESIS 9 45 0.0001228 0.003285
175 NEGATIVE REGULATION OF CELL DEATH 62 872 0.0001246 0.003312
176 REPRODUCTIVE SYSTEM DEVELOPMENT 35 408 0.0001276 0.003354
177 GLYCOSYLATION 26 267 0.0001271 0.003354
178 REGULATION OF SYSTEM PROCESS 41 507 0.0001287 0.003357
179 REGULATION OF CHEMOTAXIS 20 180 0.0001291 0.003357
180 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 77 1152 0.0001445 0.003735
181 SODIUM ION TRANSMEMBRANE TRANSPORT 13 90 0.0001461 0.003757
182 RESPONSE TO WOUNDING 44 563 0.0001599 0.004065
183 REGULATION OF VESICLE MEDIATED TRANSPORT 38 462 0.0001594 0.004065
184 RESPONSE TO INORGANIC SUBSTANCE 39 479 0.0001621 0.004098
185 CARDIAC MUSCLE CELL ACTION POTENTIAL 8 37 0.0001646 0.004139
186 HEART MORPHOGENESIS 22 212 0.0001663 0.004161
187 REGULATION OF CELL JUNCTION ASSEMBLY 11 68 0.0001682 0.004185
188 IMMUNE SYSTEM DEVELOPMENT 45 582 0.0001721 0.004238
189 BONE DEVELOPMENT 18 156 0.0001716 0.004238
190 CELLULAR RESPONSE TO OXYGEN LEVELS 17 143 0.0001794 0.004394
191 EXTRACELLULAR STRUCTURE ORGANIZATION 28 304 0.0001839 0.00448
192 CARDIAC CHAMBER DEVELOPMENT 17 144 0.0001953 0.004733
193 GLYCOPROTEIN METABOLIC PROCESS 31 353 0.0002013 0.004852
194 RESPONSE TO ISCHEMIA 7 29 0.0002036 0.004857
195 CARDIAC MUSCLE CELL CONTRACTION 7 29 0.0002036 0.004857
196 DIGESTIVE TRACT MORPHOGENESIS 9 48 0.0002067 0.004906
197 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 34 404 0.000227 0.005362
198 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 17 146 0.0002308 0.005396
199 UDP N ACETYLGLUCOSAMINE METABOLIC PROCESS 5 14 0.0002304 0.005396
200 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 16 133 0.0002399 0.005581
201 SKELETAL SYSTEM DEVELOPMENT 37 455 0.0002421 0.005589
202 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 8 39 0.0002427 0.005589
203 REGULATION OF METAL ION TRANSPORT 29 325 0.0002442 0.005597
204 FOREBRAIN DEVELOPMENT 31 357 0.0002455 0.005599
205 NEGATIVE REGULATION OF CELL COMMUNICATION 78 1192 0.0002534 0.005751
206 MESENCHYMAL CELL DIFFERENTIATION 16 134 0.0002616 0.005908
207 NEURON PROJECTION GUIDANCE 21 205 0.000277 0.006227
208 MEMBRANE DEPOLARIZATION 10 61 0.0002951 0.006507
209 EMBRYONIC DIGIT MORPHOGENESIS 10 61 0.0002951 0.006507
210 DEVELOPMENTAL PIGMENTATION 8 40 0.0002918 0.006507
211 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 14 109 0.0002925 0.006507
212 GROWTH 34 410 0.0002982 0.006544
213 REGULATION OF LIPID METABOLIC PROCESS 26 282 0.000303 0.00662
214 PROTEIN AUTOPHOSPHORYLATION 20 192 0.0003079 0.006694
215 POSITIVE REGULATION OF CATABOLIC PROCESS 33 395 0.0003184 0.006832
216 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 46 616 0.0003195 0.006832
217 MUSCLE CELL DIFFERENTIATION 23 237 0.0003201 0.006832
218 REGULATION OF OSSIFICATION 19 178 0.0003164 0.006832
219 FORMATION OF PRIMARY GERM LAYER 14 110 0.0003219 0.00684
220 POSITIVE REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 5 15 0.0003332 0.007015
221 REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 5 15 0.0003332 0.007015
222 MEMORY 13 98 0.0003464 0.007227
223 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 13 98 0.0003464 0.007227
224 REGULATION OF EPITHELIAL CELL PROLIFERATION 26 285 0.000357 0.007415
225 ACTIN MEDIATED CELL CONTRACTION 11 74 0.0003612 0.007469
226 REGULATION OF EPITHELIAL CELL MIGRATION 18 166 0.0003718 0.007655
227 EAR DEVELOPMENT 20 195 0.0003773 0.007733
228 NEGATIVE REGULATION OF CELL CYCLE 35 433 0.0003941 0.008042
229 PROTEIN N LINKED GLYCOSYLATION 11 75 0.0004068 0.008194
230 ARTERY DEVELOPMENT 11 75 0.0004068 0.008194
231 REGULATION OF MAP KINASE ACTIVITY 28 319 0.0004045 0.008194
232 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 60 876 0.0004236 0.008495
233 RESPIRATORY SYSTEM DEVELOPMENT 20 197 0.0004308 0.008603
234 CELL FATE COMMITMENT 22 227 0.0004358 0.008666
235 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 9 53 0.000449 0.00889
236 POSITIVE REGULATION OF MAPK CASCADE 37 470 0.0004517 0.008905
237 GASTRULATION 17 155 0.0004687 0.009202
238 REGULATION OF ION TRANSPORT 44 592 0.0004722 0.009232
239 EMBRYONIC CAMERA TYPE EYE MORPHOGENESIS 6 24 0.0004768 0.009282
240 REGULATION OF ANATOMICAL STRUCTURE SIZE 37 472 0.0004893 0.009486
241 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 541 0.0004948 0.009514
242 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 41 541 0.0004948 0.009514
243 REGULATION OF CELLULAR LOCALIZATION 81 1277 0.0005043 0.009656
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 96 1199 6.434e-09 1.993e-06
2 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 40 328 5.154e-09 1.993e-06
3 ENZYME BINDING 128 1737 2.781e-09 1.993e-06
4 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 60 629 1.35e-08 3.135e-06
5 MACROMOLECULAR COMPLEX BINDING 104 1399 6.774e-08 1.259e-05
6 KINASE ACTIVITY 71 842 9.648e-08 1.494e-05
7 CYTOSKELETAL PROTEIN BINDING 69 819 1.524e-07 2.022e-05
8 CALCIUM ION BINDING 61 697 2.25e-07 2.613e-05
9 ACTIN BINDING 40 393 7.144e-07 6.023e-05
10 PROTEIN KINASE ACTIVITY 56 640 7.163e-07 6.023e-05
11 REGULATORY REGION NUCLEIC ACID BINDING 67 818 6.431e-07 6.023e-05
12 RIBONUCLEOTIDE BINDING 125 1860 7.78e-07 6.023e-05
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 34 315 1.301e-06 9.297e-05
14 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 75 992 2.846e-06 0.0001888
15 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 32 303 4.212e-06 0.0002446
16 SEQUENCE SPECIFIC DNA BINDING 77 1037 4.062e-06 0.0002446
17 PROTEIN COMPLEX BINDING 71 935 4.551e-06 0.0002487
18 DOUBLE STRANDED DNA BINDING 60 764 9.292e-06 0.0004796
19 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 7 20 1.428e-05 0.0006935
20 PROTEIN SERINE THREONINE KINASE ACTIVITY 40 445 1.493e-05 0.0006935
21 MOLECULAR FUNCTION REGULATOR 91 1353 2.8e-05 0.001239
22 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 15 105 5.275e-05 0.002228
23 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 24 226 5.947e-05 0.002374
24 PROTEIN DOMAIN SPECIFIC BINDING 49 624 6.132e-05 0.002374
25 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 228 6.842e-05 0.002542
26 ADENYL NUCLEOTIDE BINDING 97 1514 9.68e-05 0.003459
27 HORMONE BINDING 11 65 0.0001107 0.003808
28 CALMODULIN BINDING 20 179 0.0001196 0.003968
29 PROTEIN DIMERIZATION ACTIVITY 77 1149 0.0001331 0.004122
30 TRANSCRIPTION FACTOR BINDING 42 524 0.0001299 0.004122
31 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 19 168 0.0001494 0.004477
32 RECEPTOR BINDING 94 1476 0.0001544 0.004482
33 PROTEIN HOMODIMERIZATION ACTIVITY 53 722 0.0001761 0.004959
34 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 13 92 0.0001832 0.005005
35 KINASE BINDING 46 606 0.0002221 0.005732
36 CORE PROMOTER PROXIMAL REGION DNA BINDING 32 371 0.0002216 0.005732
37 GTPASE BINDING 27 295 0.0002633 0.006611
38 SMAD BINDING 11 72 0.0002828 0.006913
39 SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 16 136 0.00031 0.007385
40 CAMP BINDING 6 23 0.0003712 0.008622
41 METALLOENDOPEPTIDASE ACTIVITY 14 113 0.0004258 0.009647
42 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 9 53 0.000449 0.009931
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 95 1151 1.676e-09 9.788e-07
2 MEMBRANE REGION 93 1134 3.486e-09 1.018e-06
3 CELL LEADING EDGE 40 350 3.234e-08 6.296e-06
4 GOLGI APPARATUS 106 1445 9.763e-08 1.425e-05
5 CELL SUBSTRATE JUNCTION 41 398 3.78e-07 4.01e-05
6 PLASMA MEMBRANE REGION 74 929 4.807e-07 4.01e-05
7 CELL PROJECTION 122 1786 4.649e-07 4.01e-05
8 ANCHORING JUNCTION 46 489 1.007e-06 7.35e-05
9 INTRACELLULAR VESICLE 90 1259 2.898e-06 0.0001881
10 MEMBRANE MICRODOMAIN 31 288 4.007e-06 0.000234
11 NEURON PART 89 1265 6.227e-06 0.0003306
12 NEURON PROJECTION 70 942 1.103e-05 0.0005368
13 VOLTAGE GATED SODIUM CHANNEL COMPLEX 6 14 1.55e-05 0.0006964
14 T TUBULE 10 45 1.968e-05 0.0008181
15 PLASMA MEMBRANE RAFT 14 86 2.101e-05 0.0008181
16 PROTEIN KINASE COMPLEX 14 90 3.558e-05 0.001299
17 ORGANELLE SUBCOMPARTMENT 30 311 4.739e-05 0.001628
18 GOLGI CISTERNA 14 93 5.17e-05 0.001677
19 SODIUM CHANNEL COMPLEX 6 17 5.704e-05 0.001753
20 ACTIN CYTOSKELETON 38 444 6.998e-05 0.001946
21 LAMELLIPODIUM 20 172 6.856e-05 0.001946
22 TRANSFERASE COMPLEX 53 703 9.006e-05 0.002391
23 GOLGI STACK 16 125 0.0001156 0.002936
24 SYNAPSE 55 754 0.0001569 0.003819
25 CYTOSKELETON 119 1967 0.0001708 0.003854
26 RUFFLE 18 156 0.0001716 0.003854
27 CELL CELL JUNCTION 33 383 0.0001814 0.003924
28 ACTIN FILAMENT 11 70 0.0002192 0.004573
29 GOLGI APPARATUS PART 62 893 0.0002381 0.004738
30 ENDOPLASMIC RETICULUM 101 1631 0.0002434 0.004738
31 LEADING EDGE MEMBRANE 16 134 0.0002616 0.004927
32 POSTSYNAPSE 32 378 0.0003091 0.005642
33 ACTOMYOSIN 10 62 0.0003382 0.005986
34 EARLY ENDOSOME 27 301 0.0003627 0.00623
35 CYTOPLASMIC REGION 26 287 0.0003975 0.006448
36 ACTIN BASED CELL PROJECTION 19 181 0.000391 0.006448
37 CELL CELL CONTACT ZONE 10 64 0.0004403 0.00695
38 VACUOLE 76 1180 0.0004847 0.007448
39 ENDOPLASMIC RETICULUM LUMEN 20 201 0.0005579 0.008146
40 GOLGI MEMBRANE 50 703 0.0005494 0.008146
41 APICAL PART OF CELL 30 361 0.0006375 0.008865
42 CELL PROJECTION PART 63 946 0.0006356 0.008865

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 22 132 6.577e-08 3.42e-06
2 Sphingolipid_signaling_pathway_hsa04071 18 118 3.794e-06 9.866e-05
3 Focal_adhesion_hsa04510 24 199 7.188e-06 0.0001246
4 Rap1_signaling_pathway_hsa04015 22 206 0.0001095 0.001317
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 17 139 0.0001266 0.001317
6 PI3K_Akt_signaling_pathway_hsa04151 31 352 0.0001914 0.001454
7 Endocytosis_hsa04144 24 244 0.0001957 0.001454
8 HIF_1_signaling_pathway_hsa04066 13 100 0.0004229 0.002749
9 Cellular_senescence_hsa04218 17 160 0.0006757 0.003754
10 p53_signaling_pathway_hsa04115 10 68 0.0007219 0.003754
11 Hedgehog_signaling_pathway_hsa04340 8 47 0.0009101 0.004302
12 Tight_junction_hsa04530 17 170 0.001331 0.005767
13 Autophagy_animal_hsa04140 14 128 0.001476 0.005898
14 Gap_junction_hsa04540 11 88 0.001588 0.005898
15 AMPK_signaling_pathway_hsa04152 13 121 0.002518 0.008396
16 mTOR_signaling_pathway_hsa04150 15 151 0.002657 0.008396
17 TNF_signaling_pathway_hsa04668 12 108 0.002745 0.008396
18 Hippo_signaling_pathway_hsa04390 15 154 0.00321 0.009274
19 ErbB_signaling_pathway_hsa04012 10 85 0.003989 0.01092
20 cGMP_PKG_signaling_pathway_hsa04022 15 163 0.005459 0.01405
21 MAPK_signaling_pathway_hsa04010 23 295 0.005675 0.01405
22 cAMP_signaling_pathway_hsa04024 17 198 0.00646 0.01527
23 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.007923 0.01791
24 TGF_beta_signaling_pathway_hsa04350 9 84 0.01121 0.02429
25 Phospholipase_D_signaling_pathway_hsa04072 13 146 0.01207 0.0251
26 Apoptosis_multiple_species_hsa04215 5 33 0.01371 0.02743
27 Apelin_signaling_pathway_hsa04371 12 137 0.01744 0.03359
28 Apoptosis_hsa04210 12 138 0.01837 0.03412
29 Oocyte_meiosis_hsa04114 11 124 0.02046 0.03668
30 Ras_signaling_pathway_hsa04014 17 232 0.02717 0.04558
31 Wnt_signaling_pathway_hsa04310 12 146 0.02717 0.04558
32 Jak_STAT_signaling_pathway_hsa04630 12 162 0.05329 0.0866
33 ECM_receptor_interaction_hsa04512 7 82 0.06807 0.1073
34 Calcium_signaling_pathway_hsa04020 12 182 0.1047 0.1601
35 VEGF_signaling_pathway_hsa04370 5 59 0.116 0.1723
36 Regulation_of_actin_cytoskeleton_hsa04810 13 208 0.1271 0.1836
37 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.1441 0.2025
38 Cytokine_cytokine_receptor_interaction_hsa04060 15 270 0.208 0.2775
39 Adherens_junction_hsa04520 5 72 0.2081 0.2775
40 Peroxisome_hsa04146 5 83 0.2994 0.3892
41 ABC_transporters_hsa02010 3 45 0.3159 0.3942
42 Mitophagy_animal_hsa04137 4 65 0.3184 0.3942
43 Notch_signaling_pathway_hsa04330 3 48 0.3523 0.426
44 Lysosome_hsa04142 6 123 0.4545 0.5341
45 Cell_cycle_hsa04110 6 124 0.4622 0.5341
46 Phagosome_hsa04145 7 152 0.502 0.5675
47 Necroptosis_hsa04217 6 164 0.7301 0.8077
48 Cell_adhesion_molecules_.CAMs._hsa04514 5 145 0.7673 0.8142
49 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.7924 0.8241
50 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.9245 0.9245

Quest ID: 9d9131776a0f954b5204210635311612