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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-130b-3p ABCA1 3.54 0 -0.71 0.00276 miRNATAP -0.14 2.0E-5 NA
2 hsa-miR-130b-3p ACVR1 3.54 0 -0.44 0.01143 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0 NA
3 hsa-miR-130b-3p ADAM12 3.54 0 0.88 0.05623 miRNATAP -0.18 0.00542 NA
4 hsa-miR-130b-3p ADAMTS18 3.54 0 -0.74 0.14599 miRNATAP -0.22 0.00196 NA
5 hsa-miR-130b-3p ADARB1 3.54 0 -1.93 0 miRNAWalker2 validate -0.38 0 NA
6 hsa-miR-130b-3p ADCY2 3.54 0 -3.87 0 miRNATAP -0.61 0 NA
7 hsa-miR-130b-3p AKAP11 3.54 0 -0.8 0 miRNAWalker2 validate; miRNATAP -0.12 0 NA
8 hsa-miR-130b-3p AKAP7 3.54 0 -1.26 1.0E-5 miRNATAP -0.2 0 NA
9 hsa-miR-130b-3p AKNA 3.54 0 -0.9 2.0E-5 mirMAP -0.16 0 NA
10 hsa-miR-130b-3p ALPK3 3.54 0 -1.02 0.00049 mirMAP -0.19 0 NA
11 hsa-miR-130b-3p AMOTL1 3.54 0 -1.62 0 mirMAP -0.25 0 NA
12 hsa-miR-130b-3p AMPD3 3.54 0 0.05 0.81987 MirTarget; miRNATAP -0.11 0.00025 NA
13 hsa-miR-130b-3p ANKRD29 3.54 0 -3.47 0 miRNAWalker2 validate -0.73 0 NA
14 hsa-miR-130b-3p ANXA11 3.54 0 -0.43 0.01849 mirMAP -0.13 0 NA
15 hsa-miR-130b-3p APBB2 3.54 0 -0.59 0.0014 mirMAP -0.15 0 NA
16 hsa-miR-130b-3p APCDD1 3.54 0 -1.6 0 MirTarget -0.19 7.0E-5 NA
17 hsa-miR-130b-3p AR 3.54 0 -3.3 0 mirMAP; miRNATAP -0.36 0.00013 NA
18 hsa-miR-130b-3p ARHGAP1 3.54 0 -0.88 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.24 0 NA
19 hsa-miR-130b-3p ARHGAP26 3.54 0 -0.72 0.00357 mirMAP -0.12 0.00037 NA
20 hsa-miR-130b-3p ARRDC3 3.54 0 -0.71 0.00062 miRNAWalker2 validate; miRNATAP -0.14 0 NA
21 hsa-miR-130b-3p ASPA 3.54 0 -4.76 0 mirMAP -0.71 0 NA
22 hsa-miR-130b-3p ASXL3 3.54 0 -3.34 0 mirMAP -0.4 0 NA
23 hsa-miR-130b-3p ATP6V1B2 3.54 0 -0.17 0.24474 MirTarget; miRNATAP -0.11 0 NA
24 hsa-miR-130b-3p ATXN1 3.54 0 -1.51 0 miRNATAP -0.35 0 NA
25 hsa-miR-130b-3p BACH2 3.54 0 -1.52 0.00134 mirMAP; miRNATAP -0.36 0 NA
26 hsa-miR-130b-3p BBX 3.54 0 -0.51 0.00131 MirTarget; miRNATAP -0.12 0 NA
27 hsa-miR-130b-3p BCL9L 3.54 0 -0.07 0.6694 mirMAP -0.1 1.0E-5 NA
28 hsa-miR-130b-3p BEND4 3.54 0 -1.97 7.0E-5 mirMAP -0.16 0.02105 NA
29 hsa-miR-130b-3p BMP6 3.54 0 -0.5 0.12985 MirTarget -0.16 0.00047 NA
30 hsa-miR-130b-3p BMPR2 3.54 0 -0.59 4.0E-5 MirTarget; miRNATAP -0.13 0 NA
31 hsa-miR-130b-3p BTG1 3.54 0 -0.8 2.0E-5 miRNATAP -0.17 0 NA
32 hsa-miR-130b-3p BVES 3.54 0 -2.76 0 mirMAP -0.4 0 NA
33 hsa-miR-130b-3p C15orf52 3.54 0 -1.18 0.0026 mirMAP -0.31 0 NA
34 hsa-miR-130b-3p C1S 3.54 0 -1.94 3.0E-5 MirTarget -0.6 0 NA
35 hsa-miR-130b-3p C5 3.54 0 -0.99 0.00071 MirTarget -0.18 1.0E-5 NA
36 hsa-miR-130b-3p CA13 3.54 0 -0.29 0.3488 MirTarget -0.11 0.00829 NA
37 hsa-miR-130b-3p CADM2 3.54 0 -3.84 0 MirTarget; miRNATAP -0.18 0.03102 NA
38 hsa-miR-130b-3p CAMK4 3.54 0 -1.28 0.0022 mirMAP -0.26 1.0E-5 NA
39 hsa-miR-130b-3p CCDC50 3.54 0 -0.78 0 mirMAP -0.13 0 NA
40 hsa-miR-130b-3p CCDC6 3.54 0 -0.27 0.05122 MirTarget -0.11 0 NA
41 hsa-miR-130b-3p CCDC69 3.54 0 -2.71 0 mirMAP -0.44 0 NA
42 hsa-miR-130b-3p CCDC85A 3.54 0 -1.95 0 miRNATAP -0.23 3.0E-5 NA
43 hsa-miR-130b-3p CCDC88A 3.54 0 -0.76 0.01199 miRNATAP -0.18 3.0E-5 NA
44 hsa-miR-130b-3p CCR6 3.54 0 -1.12 0.00057 mirMAP -0.3 0 NA
45 hsa-miR-130b-3p CD109 3.54 0 -0.51 0.31559 mirMAP -0.31 1.0E-5 NA
46 hsa-miR-130b-3p CD69 3.54 0 -2.49 0 miRNATAP -0.54 0 NA
47 hsa-miR-130b-3p CD99L2 3.54 0 -1.2 0 mirMAP -0.22 0 NA
48 hsa-miR-130b-3p CDH11 3.54 0 -1.4 0.00163 mirMAP -0.45 0 NA
49 hsa-miR-130b-3p CDON 3.54 0 -2.61 0 MirTarget -0.37 0 NA
50 hsa-miR-130b-3p CERK 3.54 0 -1.14 9.0E-5 mirMAP -0.19 0 NA
51 hsa-miR-130b-3p CFL2 3.54 0 -2.62 0 MirTarget -0.42 0 NA
52 hsa-miR-130b-3p CFLAR 3.54 0 -0.23 0.20284 mirMAP -0.15 0 NA
53 hsa-miR-130b-3p CHD5 3.54 0 -3.46 0 MirTarget; miRNATAP -0.26 4.0E-5 NA
54 hsa-miR-130b-3p CHD9 3.54 0 -0.8 1.0E-5 miRNATAP -0.14 0 NA
55 hsa-miR-130b-3p CHST1 3.54 0 0.15 0.68777 MirTarget -0.16 0.00185 NA
56 hsa-miR-130b-3p CHST11 3.54 0 0.54 0.2311 MirTarget -0.13 0.04363 NA
57 hsa-miR-130b-3p CIITA 3.54 0 -0.02 0.95968 mirMAP -0.28 1.0E-5 NA
58 hsa-miR-130b-3p CLIC4 3.54 0 -1.72 0 miRNAWalker2 validate -0.27 0 NA
59 hsa-miR-130b-3p CLIP1 3.54 0 -0.85 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 0 NA
60 hsa-miR-130b-3p CLUAP1 3.54 0 -0.82 3.0E-5 mirMAP -0.14 0 NA
61 hsa-miR-130b-3p CNR2 3.54 0 -2.05 6.0E-5 mirMAP -0.45 0 NA
62 hsa-miR-130b-3p COL4A4 3.54 0 -2.67 0 mirMAP -0.44 0 NA
63 hsa-miR-130b-3p CPEB1 3.54 0 -4.68 0 MirTarget; miRNATAP -0.76 0 NA
64 hsa-miR-130b-3p CPEB3 3.54 0 -1.3 0 MirTarget; miRNATAP -0.19 0 NA
65 hsa-miR-130b-3p CPEB4 3.54 0 -1.56 0 miRNATAP -0.24 0 NA
66 hsa-miR-130b-3p CPPED1 3.54 0 -0.72 0.0334 miRNAWalker2 validate -0.18 9.0E-5 NA
67 hsa-miR-130b-3p CREB5 3.54 0 -2.28 0 miRNATAP -0.39 0 NA
68 hsa-miR-130b-3p CRY2 3.54 0 -1.68 0 miRNAWalker2 validate -0.23 0 NA
69 hsa-miR-130b-3p CSF1 3.54 0 -1.3 0.00033 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.41 0 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation
70 hsa-miR-130b-3p CTSK 3.54 0 -1.41 0.00081 MirTarget -0.45 0 NA
71 hsa-miR-130b-3p CYLD 3.54 0 -0.89 0 miRNATAP -0.21 0 27391066; 26711782 Importantly we verify that through deceasing the expression of Cylindromatosis CYLD a K63-specific DUB and endogenous blocker of NF-κB signaling miR-130b can in return sustain the persistent activation of NF-κB which may promote the malignant progression of TCC;MiR 130b inhibits proliferation and induces apoptosis of gastric cancer cells via CYLD; Bioinformatics analyses showed that cylindromatosis gene CYLD was a potential target gene of miR-130b; The luciferase activity assay and western blot verified that miR-130b targeted CYLD messenger RNA mRNA to modulate its protein levels; Together our study suggests that aberrantly expressed miR-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD which appears to be a promising therapeutic target for gastric cancer
72 hsa-miR-130b-3p CYP2U1 3.54 0 -1.21 0 MirTarget -0.24 0 NA
73 hsa-miR-130b-3p DAAM1 3.54 0 -0.94 0.00028 MirTarget; miRNATAP -0.11 0.00345 NA
74 hsa-miR-130b-3p DENND5B 3.54 0 -1.35 0.0001 mirMAP -0.17 0.00047 NA
75 hsa-miR-130b-3p DIAPH2 3.54 0 -0.89 0.00037 mirMAP -0.1 0.00301 NA
76 hsa-miR-130b-3p DLL1 3.54 0 -0.9 0.01032 miRNATAP -0.14 0.00608 NA
77 hsa-miR-130b-3p DNM3 3.54 0 -1.22 4.0E-5 mirMAP -0.2 0 NA
78 hsa-miR-130b-3p DPYSL2 3.54 0 -1.76 0 MirTarget; miRNATAP -0.27 0 NA
79 hsa-miR-130b-3p DSEL 3.54 0 -1.79 0 MirTarget; miRNATAP -0.23 0 NA
80 hsa-miR-130b-3p DTNA 3.54 0 -4.06 0 mirMAP -0.65 0 NA
81 hsa-miR-130b-3p DUSP8 3.54 0 -2.17 0 miRNAWalker2 validate -0.27 0 NA
82 hsa-miR-130b-3p EBF3 3.54 0 -2.22 0 MirTarget -0.34 0 NA
83 hsa-miR-130b-3p EDA 3.54 0 -1.83 3.0E-5 MirTarget; miRNATAP -0.24 0.0001 NA
84 hsa-miR-130b-3p EDN1 3.54 0 -0.35 0.36497 MirTarget -0.25 0 NA
85 hsa-miR-130b-3p EFR3A 3.54 0 -0.35 0.02542 MirTarget -0.12 0 NA
86 hsa-miR-130b-3p EGR2 3.54 0 -2.81 0 miRNAWalker2 validate -0.48 0 NA
87 hsa-miR-130b-3p ELK3 3.54 0 -0.31 0.25641 MirTarget; miRNATAP -0.15 7.0E-5 NA
88 hsa-miR-130b-3p ELL2 3.54 0 -1.08 1.0E-5 MirTarget -0.24 0 NA
89 hsa-miR-130b-3p EMCN 3.54 0 -2.36 0 mirMAP -0.35 0 NA
90 hsa-miR-130b-3p ENDOD1 3.54 0 -0.33 0.14647 MirTarget -0.14 2.0E-5 NA
91 hsa-miR-130b-3p ENPP5 3.54 0 -1.2 0.02004 miRNAWalker2 validate -0.14 0.0471 NA
92 hsa-miR-130b-3p ESR1 3.54 0 -2.87 0 miRNATAP -0.52 0 NA
93 hsa-miR-130b-3p F3 3.54 0 -1.93 0.00015 miRNAWalker2 validate -0.38 0 NA
94 hsa-miR-130b-3p FAM129A 3.54 0 -2.92 0 miRNAWalker2 validate -0.56 0 NA
95 hsa-miR-130b-3p FAM129C 3.54 0 -1.9 0.00038 MirTarget -0.36 0 NA
96 hsa-miR-130b-3p FAM155A 3.54 0 -1.94 0 MirTarget -0.31 0 NA
97 hsa-miR-130b-3p FAM46B 3.54 0 -3.33 0 MirTarget; miRNATAP -0.62 0 NA
98 hsa-miR-130b-3p FAM78A 3.54 0 -0.18 0.57167 MirTarget -0.21 0 NA
99 hsa-miR-130b-3p FAT3 3.54 0 -2.79 0 miRNAWalker2 validate; MirTarget -0.27 0.00126 NA
100 hsa-miR-130b-3p FBXL5 3.54 0 -0.66 0 miRNAWalker2 validate -0.11 0 NA
101 hsa-miR-130b-3p FIBIN 3.54 0 -1.93 0.00102 MirTarget -0.56 0 NA
102 hsa-miR-130b-3p FLYWCH1 3.54 0 -0.47 0.00219 mirMAP -0.13 0 NA
103 hsa-miR-130b-3p FMN1 3.54 0 -0.37 0.4819 mirMAP -0.3 5.0E-5 NA
104 hsa-miR-130b-3p FOXF2 3.54 0 -1.01 0.00891 miRNATAP -0.11 0.03859 NA
105 hsa-miR-130b-3p FOXO3 3.54 0 -0.74 0 mirMAP -0.14 0 NA
106 hsa-miR-130b-3p FOXP1 3.54 0 -0.87 0 MirTarget -0.13 0 NA
107 hsa-miR-130b-3p FRMD6 3.54 0 -0.93 0.00183 MirTarget -0.24 0 NA
108 hsa-miR-130b-3p FRZB 3.54 0 -1.17 0.00146 MirTarget -0.25 0 NA
109 hsa-miR-130b-3p FYCO1 3.54 0 -1.62 0 miRNAWalker2 validate -0.27 0 NA
110 hsa-miR-130b-3p FZD4 3.54 0 -0.83 0.00068 mirMAP -0.14 4.0E-5 NA
111 hsa-miR-130b-3p G0S2 3.54 0 -1.1 0.01873 MirTarget -0.34 0 NA
112 hsa-miR-130b-3p GADD45A 3.54 0 -0.84 0.00014 MirTarget; miRNATAP -0.17 0 NA
113 hsa-miR-130b-3p GALNT13 3.54 0 -1.81 0.00232 MirTarget -0.33 9.0E-5 NA
114 hsa-miR-130b-3p GAP43 3.54 0 -1.67 0.00774 miRNATAP -0.33 0.00013 NA
115 hsa-miR-130b-3p GAS1 3.54 0 -2.19 0.00038 miRNAWalker2 validate -0.65 0 NA
116 hsa-miR-130b-3p GBP4 3.54 0 0.37 0.3093 mirMAP -0.18 0.00043 NA
117 hsa-miR-130b-3p GFOD1 3.54 0 -0.94 0.00661 miRNAWalker2 validate; mirMAP -0.22 0 NA
118 hsa-miR-130b-3p GJA1 3.54 0 -1.07 0.00282 MirTarget; miRNATAP -0.12 0.01867 NA
119 hsa-miR-130b-3p GNB5 3.54 0 -0.84 0 miRNAWalker2 validate -0.16 0 NA
120 hsa-miR-130b-3p GPCPD1 3.54 0 -0.91 0 miRNATAP -0.14 0 NA
121 hsa-miR-130b-3p GRAMD1A 3.54 0 -0.03 0.89454 miRNAWalker2 validate -0.11 0.00046 NA
122 hsa-miR-130b-3p GRB10 3.54 0 -1.4 0 miRNAWalker2 validate; MirTarget -0.13 0.00069 NA
123 hsa-miR-130b-3p GZMK 3.54 0 -1.65 0.00749 MirTarget -0.58 0 NA
124 hsa-miR-130b-3p H6PD 3.54 0 -0.39 0.01374 mirMAP -0.12 0 NA
125 hsa-miR-130b-3p HABP4 3.54 0 -1.4 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.18 0 NA
126 hsa-miR-130b-3p HCFC2 3.54 0 -0.81 0 MirTarget -0.14 0 NA
127 hsa-miR-130b-3p HEG1 3.54 0 -0.95 0.00135 miRNAWalker2 validate; miRNATAP -0.33 0 NA
128 hsa-miR-130b-3p HERC3 3.54 0 -0.74 0.00166 MirTarget -0.16 0 NA
129 hsa-miR-130b-3p HHEX 3.54 0 -0.75 0.01573 miRNAWalker2 validate -0.15 0.00048 NA
130 hsa-miR-130b-3p HIPK3 3.54 0 -1.75 0 MirTarget -0.25 0 NA
131 hsa-miR-130b-3p HRH1 3.54 0 -0.42 0.09981 mirMAP -0.17 0 NA
132 hsa-miR-130b-3p IDS 3.54 0 -0.67 3.0E-5 mirMAP -0.12 0 NA
133 hsa-miR-130b-3p IGF1 3.54 0 -3.76 0 MirTarget -0.78 0 NA
134 hsa-miR-130b-3p IL15 3.54 0 -0.56 0.1044 MirTarget -0.29 0 NA
135 hsa-miR-130b-3p IL17RD 3.54 0 -1.41 2.0E-5 mirMAP -0.11 0.01569 NA
136 hsa-miR-130b-3p IL1RAP 3.54 0 0.69 0.05618 MirTarget -0.15 0.0033 NA
137 hsa-miR-130b-3p IL6R 3.54 0 -1.87 0 mirMAP -0.37 0 NA
138 hsa-miR-130b-3p IL6ST 3.54 0 -2.1 2.0E-5 miRNATAP -0.4 0 NA
139 hsa-miR-130b-3p INHBB 3.54 0 -1.64 0 miRNATAP -0.27 0 NA
140 hsa-miR-130b-3p IRF1 3.54 0 0.08 0.77621 MirTarget; miRNATAP -0.19 0 NA
141 hsa-miR-130b-3p ITGA8 3.54 0 -5.02 0 mirMAP -0.65 0 NA
142 hsa-miR-130b-3p ITGB8 3.54 0 -0.77 0.0782 MirTarget; miRNATAP -0.15 0.01389 NA
143 hsa-miR-130b-3p ITIH5 3.54 0 -4.03 0 mirMAP -0.59 0 NA
144 hsa-miR-130b-3p ITPK1 3.54 0 -0.61 0.00024 MirTarget; miRNATAP -0.16 0 NA
145 hsa-miR-130b-3p ITPR1 3.54 0 -2.58 0 MirTarget; miRNATAP -0.31 0 NA
146 hsa-miR-130b-3p JAKMIP1 3.54 0 0.37 0.50423 MirTarget; miRNATAP -0.22 0.0049 NA
147 hsa-miR-130b-3p JAM2 3.54 0 -3.24 0 miRNATAP -0.59 0 NA
148 hsa-miR-130b-3p JDP2 3.54 0 -1.47 0 mirMAP -0.23 0 NA
149 hsa-miR-130b-3p JMY 3.54 0 -0.98 0 MirTarget; miRNATAP -0.1 1.0E-5 NA
150 hsa-miR-130b-3p KATNAL1 3.54 0 -1.58 1.0E-5 miRNAWalker2 validate -0.32 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 65 1492 7.531e-13 3.504e-09
2 GROWTH 30 410 1.46e-11 3.397e-08
3 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 69 1805 5.275e-11 6.136e-08
4 TISSUE DEVELOPMENT 62 1518 4.295e-11 6.136e-08
5 CELL DEVELOPMENT 59 1426 8.389e-11 6.646e-08
6 DEVELOPMENTAL GROWTH 26 333 8.57e-11 6.646e-08
7 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 65 1672 1.079e-10 7.172e-08
8 POSITIVE REGULATION OF GENE EXPRESSION 66 1733 1.796e-10 1.045e-07
9 NEGATIVE REGULATION OF CELL PROLIFERATION 36 643 2.571e-10 1.329e-07
10 NEUROGENESIS 56 1402 1.015e-09 4.723e-07
11 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 19 207 2.217e-09 9.38e-07
12 ORGAN MORPHOGENESIS 40 841 2.91e-09 1.128e-06
13 REGULATION OF PHOSPHORUS METABOLIC PROCESS 60 1618 3.945e-09 1.412e-06
14 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 45 1036 4.58e-09 1.421e-06
15 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 45 1036 4.58e-09 1.421e-06
16 CONNECTIVE TISSUE DEVELOPMENT 18 194 4.976e-09 1.447e-06
17 REGULATION OF CELL PROLIFERATION 56 1496 1.035e-08 2.833e-06
18 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 1.178e-08 3.045e-06
19 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 29 513 1.263e-08 3.093e-06
20 SKELETAL SYSTEM DEVELOPMENT 27 455 1.5e-08 3.489e-06
21 SENSORY ORGAN DEVELOPMENT 28 493 2.061e-08 4.566e-06
22 NEGATIVE REGULATION OF CELL COMMUNICATION 47 1192 4.028e-08 8.519e-06
23 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 51 1360 4.95e-08 1.001e-05
24 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 38 876 8.434e-08 1.635e-05
25 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 41 1004 1.286e-07 2.394e-05
26 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 60 1784 1.339e-07 2.396e-05
27 POSITIVE REGULATION OF CELL COMMUNICATION 54 1532 1.443e-07 2.486e-05
28 EYE DEVELOPMENT 21 326 1.617e-07 2.686e-05
29 CARTILAGE DEVELOPMENT 14 147 1.872e-07 3.004e-05
30 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 61 1848 1.982e-07 3.074e-05
31 MUSCLE TISSUE DEVELOPMENT 19 275 2.168e-07 3.254e-05
32 REGULATION OF CELL DEVELOPMENT 36 836 2.266e-07 3.294e-05
33 BLOOD VESSEL MORPHOGENESIS 22 364 2.462e-07 3.472e-05
34 POSITIVE REGULATION OF RESPONSE TO STIMULUS 62 1929 3.907e-07 5.346e-05
35 POSITIVE REGULATION OF CELL DIFFERENTIATION 35 823 4.523e-07 6.013e-05
36 CELLULAR COMPONENT MORPHOGENESIS 37 900 4.737e-07 6.123e-05
37 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 39 983 5.551e-07 6.981e-05
38 CENTRAL NERVOUS SYSTEM DEVELOPMENT 36 872 6.201e-07 7.593e-05
39 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 55 1656 7.304e-07 8.526e-05
40 TUBE DEVELOPMENT 27 552 7.329e-07 8.526e-05
41 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 99 8.383e-07 9.035e-05
42 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 11 99 8.383e-07 9.035e-05
43 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 51 1492 8.505e-07 9.035e-05
44 REGULATION OF CELLULAR COMPONENT MOVEMENT 33 771 8.543e-07 9.035e-05
45 TISSUE MORPHOGENESIS 26 533 1.245e-06 0.0001259
46 EMBRYONIC ORGAN MORPHOGENESIS 18 279 1.227e-06 0.0001259
47 VASCULATURE DEVELOPMENT 24 469 1.409e-06 0.0001366
48 POSITIVE REGULATION OF OSSIFICATION 10 84 1.4e-06 0.0001366
49 POSITIVE REGULATION OF MAPK CASCADE 24 470 1.463e-06 0.0001389
50 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 48 1395 1.557e-06 0.000142
51 EMBRYONIC ORGAN DEVELOPMENT 22 406 1.541e-06 0.000142
52 NEURON DIFFERENTIATION 35 874 1.793e-06 0.0001605
53 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 31 724 1.854e-06 0.0001628
54 ORGAN GROWTH 9 68 1.927e-06 0.000163
55 REGULATION OF OSSIFICATION 14 178 1.918e-06 0.000163
56 RESPONSE TO ENDOGENOUS STIMULUS 49 1450 1.99e-06 0.0001654
57 REGULATION OF MAPK CASCADE 29 660 2.442e-06 0.0001993
58 CELLULAR RESPONSE TO EXTERNAL STIMULUS 17 264 2.492e-06 0.0001999
59 RESPONSE TO MECHANICAL STIMULUS 15 210 2.757e-06 0.0002175
60 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 41 1135 3.016e-06 0.0002339
61 HEAD DEVELOPMENT 30 709 3.47e-06 0.0002633
62 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 41 1142 3.509e-06 0.0002633
63 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 11 115 3.73e-06 0.0002755
64 EPITHELIUM DEVELOPMENT 36 945 3.94e-06 0.0002865
65 MUSCLE STRUCTURE DEVELOPMENT 22 432 4.219e-06 0.0002973
66 HEART DEVELOPMENT 23 466 4.281e-06 0.0002973
67 REGULATION OF PROTEIN MODIFICATION PROCESS 54 1710 4.26e-06 0.0002973
68 LOCOMOTION 40 1114 4.651e-06 0.0003182
69 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 5 16 4.803e-06 0.0003239
70 POSITIVE REGULATION OF CELL DEVELOPMENT 23 472 5.283e-06 0.0003512
71 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 6.834e-06 0.0004479
72 REGULATION OF EPITHELIAL CELL PROLIFERATION 17 285 6.936e-06 0.0004483
73 REGULATION OF NEURON DIFFERENTIATION 25 554 7.834e-06 0.0004993
74 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 102 8.281e-06 0.0005207
75 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 37 1021 8.876e-06 0.0005507
76 POSITIVE REGULATION OF LOCOMOTION 21 420 9.242e-06 0.0005658
77 TUBE MORPHOGENESIS 18 323 9.515e-06 0.000575
78 REGULATION OF CARTILAGE DEVELOPMENT 8 63 9.903e-06 0.0005907
79 CARDIOVASCULAR SYSTEM DEVELOPMENT 31 788 1.025e-05 0.0005962
80 CIRCULATORY SYSTEM DEVELOPMENT 31 788 1.025e-05 0.0005962
81 BONE DEVELOPMENT 12 156 1.305e-05 0.0007495
82 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 31 801 1.412e-05 0.000801
83 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 36 1008 1.619e-05 0.0008969
84 EXTRACELLULAR STRUCTURE ORGANIZATION 17 304 1.609e-05 0.0008969
85 ENDOTHELIUM DEVELOPMENT 9 90 2e-05 0.001095
86 NEGATIVE REGULATION OF GENE EXPRESSION 47 1493 2.108e-05 0.00114
87 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 42 1275 2.135e-05 0.001142
88 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 8 70 2.181e-05 0.001153
89 REGULATION OF CELL ADHESION 26 629 2.369e-05 0.001239
90 CARDIAC MUSCLE TISSUE DEVELOPMENT 11 140 2.453e-05 0.001268
91 RESPONSE TO EXTERNAL STIMULUS 54 1821 2.545e-05 0.001301
92 REGULATION OF CELL PROJECTION ORGANIZATION 24 558 2.607e-05 0.001318
93 ENDOTHELIAL CELL DIFFERENTIATION 8 72 2.686e-05 0.001344
94 INFLAMMATORY RESPONSE 21 454 2.944e-05 0.001457
95 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 34 957 3.135e-05 0.001504
96 CELL MOTILITY 31 835 3.134e-05 0.001504
97 LOCALIZATION OF CELL 31 835 3.134e-05 0.001504
98 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 121 3.717e-05 0.001765
99 ANGIOGENESIS 16 293 3.8e-05 0.001786
100 MEMORY 9 98 3.965e-05 0.001845
101 EMBRYONIC MORPHOGENESIS 23 539 4.34e-05 0.002
102 RHYTHMIC PROCESS 16 298 4.654e-05 0.002103
103 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 100 4.654e-05 0.002103
104 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 13 4.906e-05 0.002195
105 MUSCLE CELL DIFFERENTIATION 14 237 4.978e-05 0.002206
106 NEURON PROJECTION MORPHOGENESIS 19 402 5.289e-05 0.002322
107 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 18 368 5.357e-05 0.00233
108 SENSORY ORGAN MORPHOGENESIS 14 239 5.453e-05 0.002349
109 CELL CYCLE ARREST 11 154 5.904e-05 0.00252
110 POSITIVE REGULATION OF NEURON DIFFERENTIATION 16 306 6.373e-05 0.002624
111 CHONDROCYTE DIFFERENTIATION 7 60 6.265e-05 0.002624
112 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 7 60 6.265e-05 0.002624
113 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 9 104 6.341e-05 0.002624
114 REGULATION OF NEURON PROJECTION DEVELOPMENT 19 408 6.443e-05 0.00263
115 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 750 6.956e-05 0.002814
116 RETINA DEVELOPMENT IN CAMERA TYPE EYE 10 131 7.313e-05 0.002908
117 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 10 131 7.313e-05 0.002908
118 PATTERN SPECIFICATION PROCESS 19 418 8.867e-05 0.003496
119 COGNITION 14 251 9.219e-05 0.003605
120 NEGATIVE REGULATION OF CELL DIFFERENTIATION 24 609 0.0001024 0.003971
121 TISSUE REMODELING 8 87 0.0001055 0.004058
122 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 26 689 0.0001067 0.00407
123 EMBRYO DEVELOPMENT 31 894 0.0001104 0.004176
124 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 7 66 0.0001159 0.004215
125 REGULATION OF EPITHELIAL CELL MIGRATION 11 166 0.0001159 0.004215
126 OVULATION CYCLE PROCESS 8 88 0.0001144 0.004215
127 REGULATION OF OSTEOBLAST DIFFERENTIATION 9 112 0.0001128 0.004215
128 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 7 66 0.0001159 0.004215
129 FOREBRAIN DEVELOPMENT 17 357 0.0001191 0.004276
130 TAXIS 20 464 0.0001195 0.004276
131 REGULATION OF KINASE ACTIVITY 28 776 0.0001239 0.0044
132 REGULATION OF AXONOGENESIS 11 168 0.000129 0.004546
133 TELENCEPHALON DEVELOPMENT 13 228 0.0001313 0.004593
134 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 27 740 0.0001368 0.004749
135 NEURON PROJECTION DEVELOPMENT 22 545 0.0001417 0.004885
136 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 6 48 0.0001432 0.004901
137 MORPHOGENESIS OF AN EPITHELIUM 18 400 0.0001535 0.005212
138 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 19 437 0.0001577 0.005318
139 STRIATED MUSCLE CELL DIFFERENTIATION 11 173 0.000167 0.00559
140 UROGENITAL SYSTEM DEVELOPMENT 15 299 0.0001694 0.00563
141 PATTERNING OF BLOOD VESSELS 5 32 0.0001777 0.005864
142 NEURON PROJECTION GUIDANCE 12 205 0.0001856 0.006081
143 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 337 0.0001944 0.006326
144 REPRODUCTIVE SYSTEM DEVELOPMENT 18 408 0.0001958 0.006327
145 MYELOID LEUKOCYTE DIFFERENTIATION 8 96 0.0002103 0.006747
146 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 23 602 0.0002234 0.00712
147 CELLULAR RESPONSE TO AMINO ACID STIMULUS 6 53 0.0002498 0.007908
148 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 44 1517 0.0002542 0.007991
149 REGULATION OF CELL DEATH 43 1472 0.0002581 0.008061
150 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 10 153 0.0002633 0.008166
151 AMEBOIDAL TYPE CELL MIGRATION 10 154 0.0002774 0.008512
152 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 8 100 0.0002785 0.008512
153 EPITHELIAL CELL DIFFERENTIATION 20 495 0.0002799 0.008512
154 CELL PROJECTION ORGANIZATION 30 902 0.0002912 0.008799
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 34 629 2.06e-09 1.914e-06
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 22 315 1.94e-08 9.01e-06
3 CYTOKINE BINDING 12 92 4.381e-08 1.018e-05
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 3.997e-08 1.018e-05
5 REGULATORY REGION NUCLEIC ACID BINDING 35 818 3.923e-07 5.206e-05
6 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 17 226 2.878e-07 5.206e-05
7 CORE PROMOTER PROXIMAL REGION DNA BINDING 22 371 3.41e-07 5.206e-05
8 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 10 81 9.96e-07 0.0001128
9 GROWTH FACTOR BINDING 12 123 1.093e-06 0.0001128
10 TRANSFORMING GROWTH FACTOR BETA BINDING 5 16 4.803e-06 0.000411
11 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 42 1199 4.866e-06 0.000411
12 LIPID BINDING 28 657 6.505e-06 0.0004796
13 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 5 17 6.711e-06 0.0004796
14 RECEPTOR BINDING 48 1476 7.262e-06 0.0004819
15 DOUBLE STRANDED DNA BINDING 30 764 1.484e-05 0.0009189
16 CYTOKINE RECEPTOR BINDING 15 271 5.682e-05 0.003299
17 SEQUENCE SPECIFIC DNA BINDING 35 1037 6.747e-05 0.003687
18 ENZYME BINDING 50 1737 0.0001113 0.005744
19 SMAD BINDING 7 72 0.0002013 0.009843
NumGOOverlapSizeP ValueAdj. P Value
1 CELL SURFACE 34 757 1.902e-07 0.0001111
2 NEURON PROJECTION 34 942 2.278e-05 0.006651

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cytokine_cytokine_receptor_interaction_hsa04060 15 270 5.448e-05 0.002027
2 FoxO_signaling_pathway_hsa04068 10 132 7.797e-05 0.002027
3 MAPK_signaling_pathway_hsa04010 15 295 0.0001462 0.002535
4 mTOR_signaling_pathway_hsa04150 10 151 0.0002367 0.003077
5 TGF_beta_signaling_pathway_hsa04350 7 84 0.0005217 0.005426
6 PI3K_Akt_signaling_pathway_hsa04151 15 352 0.0009359 0.007666
7 Oocyte_meiosis_hsa04114 8 124 0.001166 0.007666
8 Hippo_signaling_pathway_hsa04390 9 154 0.001179 0.007666
9 Apelin_signaling_pathway_hsa04371 8 137 0.002198 0.01188
10 TNF_signaling_pathway_hsa04668 7 108 0.002285 0.01188
11 p53_signaling_pathway_hsa04115 5 68 0.005635 0.02338
12 Cellular_senescence_hsa04218 8 160 0.005646 0.02338
13 Autophagy_animal_hsa04140 7 128 0.005844 0.02338
14 Focal_adhesion_hsa04510 9 199 0.006535 0.02427
15 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.009039 0.03134
16 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.01233 0.04007
17 Gap_junction_hsa04540 5 88 0.01618 0.04951
18 Lysosome_hsa04142 6 123 0.01752 0.05062
19 ECM_receptor_interaction_hsa04512 4 82 0.04892 0.1339
20 AMPK_signaling_pathway_hsa04152 5 121 0.053 0.1378
21 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.05685 0.1408
22 Apoptosis_hsa04210 5 138 0.08272 0.1892
23 Calcium_signaling_pathway_hsa04020 6 182 0.08624 0.1892
24 HIF_1_signaling_pathway_hsa04066 4 100 0.08735 0.1892
25 Ras_signaling_pathway_hsa04014 7 232 0.09617 0.2
26 Endocytosis_hsa04144 7 244 0.1169 0.2338
27 Rap1_signaling_pathway_hsa04015 6 206 0.1332 0.2466
28 Sphingolipid_signaling_pathway_hsa04071 4 118 0.1366 0.2466
29 Regulation_of_actin_cytoskeleton_hsa04810 6 208 0.1375 0.2466
30 Tight_junction_hsa04530 5 170 0.1574 0.2729
31 Hedgehog_signaling_pathway_hsa04340 2 47 0.1859 0.3118
32 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.2258 0.3429
33 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.2294 0.3429
34 Wnt_signaling_pathway_hsa04310 4 146 0.2294 0.3429
35 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.2308 0.3429
36 Jak_STAT_signaling_pathway_hsa04630 4 162 0.2881 0.4161
37 Mitophagy_animal_hsa04137 2 65 0.2972 0.4176
38 Adherens_junction_hsa04520 2 72 0.3403 0.4657
39 cAMP_signaling_pathway_hsa04024 4 198 0.4242 0.5559
40 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.4992 0.618
41 Necroptosis_hsa04217 3 164 0.5201 0.6289
42 Cell_cycle_hsa04110 2 124 0.6177 0.6982
43 Phagosome_hsa04145 2 152 0.7258 0.803

Quest ID: a048aafeb1705cd38c0b3edb5f6d7d29