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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-194-5p ACADSB 0.47 0 -0.52 0.002 mirMAP -0.23 0.00038 NA
2 hsa-miR-194-5p ADAMTS5 0.47 0 -3.55 0 mirMAP -0.42 0 NA
3 hsa-miR-194-5p AFF2 0.47 0 -1.78 0 mirMAP -0.18 0.01098 NA
4 hsa-miR-194-5p ALDH1L2 0.47 0 -0.04 0.78616 mirMAP -0.2 0.00037 NA
5 hsa-miR-194-5p ANGPTL1 0.47 0 -3.72 0 MirTarget -0.55 0 NA
6 hsa-miR-194-5p ARHGAP24 0.47 0 -1.41 0 miRNATAP -0.23 0 NA
7 hsa-miR-194-5p ARHGAP5 0.47 0 -0.91 0 miRNATAP -0.18 0 NA
8 hsa-miR-194-5p ARID4A 0.47 0 -0.86 0 miRNATAP -0.14 1.0E-5 NA
9 hsa-miR-194-5p ATP8B4 0.47 0 -1.46 0 MirTarget -0.25 0 NA
10 hsa-miR-194-5p BNC1 0.47 0 -2.84 0 MirTarget -0.43 5.0E-5 NA
11 hsa-miR-194-5p BRMS1L 0.47 0 -0.44 0 MirTarget -0.12 0 NA
12 hsa-miR-194-5p BTBD7 0.47 0 -0.65 0 miRNATAP -0.11 0.0001 NA
13 hsa-miR-194-5p CADM1 0.47 0 -0.07 0.58588 miRNATAP -0.13 0.0115 NA
14 hsa-miR-194-5p CD302 0.47 0 -1.77 0 mirMAP -0.21 0 NA
15 hsa-miR-194-5p CDC42BPA 0.47 0 -0.67 0 mirMAP -0.1 0.01633 NA
16 hsa-miR-194-5p CDK14 0.47 0 -0.43 5.0E-5 MirTarget -0.17 6.0E-5 NA
17 hsa-miR-194-5p CHD9 0.47 0 -1.21 0 miRNATAP -0.21 0 NA
18 hsa-miR-194-5p CLDN19 0.47 0 -4.73 0 mirMAP -0.59 2.0E-5 NA
19 hsa-miR-194-5p CLIP4 0.47 0 -2.32 0 MirTarget -0.21 0.00162 NA
20 hsa-miR-194-5p CTDSPL 0.47 0 -0.59 0 mirMAP -0.14 0 NA
21 hsa-miR-194-5p CTTNBP2NL 0.47 0 -0.5 0 MirTarget -0.11 9.0E-5 NA
22 hsa-miR-194-5p CYP26B1 0.47 0 -2.18 0 mirMAP -0.17 0.01637 NA
23 hsa-miR-194-5p CYTH3 0.47 0 -0.74 0 mirMAP -0.15 3.0E-5 NA
24 hsa-miR-194-5p DAAM1 0.47 0 -0.83 0 miRNATAP -0.19 4.0E-5 NA
25 hsa-miR-194-5p DCBLD2 0.47 0 -0.92 0 MirTarget -0.2 0 NA
26 hsa-miR-194-5p DISC1 0.47 0 -0.75 0 MirTarget -0.13 0.00032 NA
27 hsa-miR-194-5p DMD 0.47 0 -3.78 0 MirTarget; miRNATAP -0.37 1.0E-5 NA
28 hsa-miR-194-5p EDN1 0.47 0 -1.72 0 MirTarget; miRNATAP -0.22 0.00072 NA
29 hsa-miR-194-5p EGR2 0.47 0 -2.23 0 miRNATAP -0.26 0.00013 NA
30 hsa-miR-194-5p EHBP1 0.47 0 -1.25 0 MirTarget; miRNATAP -0.12 0.00016 NA
31 hsa-miR-194-5p EIF4E3 0.47 0 -1.14 0 miRNATAP -0.11 0.00356 NA
32 hsa-miR-194-5p ELF1 0.47 0 -0.23 0.00414 miRNAWalker2 validate -0.11 0.00046 NA
33 hsa-miR-194-5p EMCN 0.47 0 -2.15 0 MirTarget -0.37 0 NA
34 hsa-miR-194-5p EPHA3 0.47 0 -0.83 4.0E-5 miRNATAP -0.45 0 NA
35 hsa-miR-194-5p ERBB4 0.47 0 -0.95 0.00612 miRNATAP -0.28 0.0415 NA
36 hsa-miR-194-5p ERG 0.47 0 -1.79 0 MirTarget -0.33 0 NA
37 hsa-miR-194-5p EXOC5 0.47 0 -0.25 0.00014 MirTarget; miRNATAP -0.1 5.0E-5 NA
38 hsa-miR-194-5p EYA4 0.47 0 -1.71 0 miRNATAP -0.55 0 NA
39 hsa-miR-194-5p FAM160B1 0.47 0 -0.62 0 miRNATAP -0.11 4.0E-5 NA
40 hsa-miR-194-5p FAM63B 0.47 0 -1.04 0 miRNATAP -0.19 0.00104 NA
41 hsa-miR-194-5p FLI1 0.47 0 -1.26 0 MirTarget -0.19 0 NA
42 hsa-miR-194-5p FOXO1 0.47 0 -1.99 0 miRNATAP -0.31 0 24631529 Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR 135b and miR 194 dysregulation; In addition Gα12QL repressed miR-194 cluster gene products 194/192/215 which contributed to MDM2-mediated FOXO1 repression; Moreover decrease of FOXO1 or miR-194 was statistically significant between stages T1 and T2 whereas increase of miR-135b discriminated tumor stage T3a versus T1/T2
43 hsa-miR-194-5p FOXP2 0.47 0 -3.11 0 miRNATAP -0.52 0 NA
44 hsa-miR-194-5p FZD5 0.47 0 -1.31 0 miRNATAP -0.18 7.0E-5 NA
45 hsa-miR-194-5p FZD6 0.47 0 -0.25 0.0729 MirTarget -0.16 0.00313 NA
46 hsa-miR-194-5p GAS7 0.47 0 -1.14 0 mirMAP -0.22 3.0E-5 NA
47 hsa-miR-194-5p GLIS3 0.47 0 0.2 0.17318 miRNATAP -0.16 0.00427 NA
48 hsa-miR-194-5p GPM6B 0.47 0 -2.23 0 miRNATAP -0.22 0.00154 NA
49 hsa-miR-194-5p HBEGF 0.47 0 -1.07 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.00361 NA
50 hsa-miR-194-5p HS3ST2 0.47 0 -0.55 0.00226 MirTarget; miRNATAP -0.34 0 NA
51 hsa-miR-194-5p ITGA9 0.47 0 -1.81 0 miRNAWalker2 validate; miRTarBase -0.12 0.04781 NA
52 hsa-miR-194-5p JKAMP 0.47 0 0.07 0.22789 MirTarget -0.11 0 NA
53 hsa-miR-194-5p KCNA1 0.47 0 -2.93 0 mirMAP -0.34 0.00094 NA
54 hsa-miR-194-5p KCTD20 0.47 0 -0.52 0 MirTarget -0.13 0.00022 NA
55 hsa-miR-194-5p KIAA1210 0.47 0 -0.75 0.00137 MirTarget -0.21 0.02059 NA
56 hsa-miR-194-5p KIAA1644 0.47 0 1.07 0 mirMAP -0.27 0.00044 NA
57 hsa-miR-194-5p KLF7 0.47 0 -0.96 0 miRNATAP -0.2 0.0002 NA
58 hsa-miR-194-5p KLHL11 0.47 0 -0.64 0.00013 MirTarget -0.14 0.03584 NA
59 hsa-miR-194-5p LANCL1 0.47 0 -0.55 0 MirTarget -0.1 0.00017 NA
60 hsa-miR-194-5p LATS1 0.47 0 -0.99 0 miRNATAP -0.17 0.00219 NA
61 hsa-miR-194-5p LGI1 0.47 0 -2.19 0 MirTarget; miRNATAP -0.3 0.00827 NA
62 hsa-miR-194-5p LHX6 0.47 0 -1.95 0 miRNATAP -0.18 0.00213 NA
63 hsa-miR-194-5p LNPEP 0.47 0 -0.99 0 mirMAP -0.15 0.00674 NA
64 hsa-miR-194-5p LPP 0.47 0 -1.17 0 mirMAP -0.16 0.00237 NA
65 hsa-miR-194-5p LRCH2 0.47 0 -1.82 0 MirTarget -0.35 0 NA
66 hsa-miR-194-5p MAF 0.47 0 -1.16 0 miRNATAP -0.21 0 NA
67 hsa-miR-194-5p MAP1B 0.47 0 -1.55 0 MirTarget -0.23 3.0E-5 NA
68 hsa-miR-194-5p MAP2 0.47 0 -1.48 0 MirTarget; miRNATAP -0.2 0.00249 NA
69 hsa-miR-194-5p MBNL2 0.47 0 -1.37 0 miRNATAP -0.19 1.0E-5 NA
70 hsa-miR-194-5p MBNL3 0.47 0 -1.93 0 mirMAP -0.15 0.04586 NA
71 hsa-miR-194-5p MEF2C 0.47 0 -1.36 0 miRNATAP -0.24 0 NA
72 hsa-miR-194-5p MEIS2 0.47 0 -1.95 0 MirTarget; miRNATAP -0.27 0 NA
73 hsa-miR-194-5p MTMR6 0.47 0 -0.34 0 MirTarget -0.12 2.0E-5 NA
74 hsa-miR-194-5p NBEA 0.47 0 -0.84 0 miRNATAP -0.2 0.00357 NA
75 hsa-miR-194-5p NFAT5 0.47 0 -1.2 0 miRNATAP -0.13 0.00014 NA
76 hsa-miR-194-5p NIPSNAP3B 0.47 0 -2.79 0 MirTarget -0.17 0.00419 NA
77 hsa-miR-194-5p NMB 0.47 0 -1.75 0 MirTarget -0.16 0.00681 NA
78 hsa-miR-194-5p NRP1 0.47 0 -1.21 0 miRNATAP -0.21 0 NA
79 hsa-miR-194-5p OPCML 0.47 0 -0.15 0.47586 miRNATAP -0.28 0.00092 NA
80 hsa-miR-194-5p OR51E2 0.47 0 0.16 0.35196 MirTarget -0.36 0 NA
81 hsa-miR-194-5p OSBPL8 0.47 0 -0.6 0 MirTarget -0.15 0.0002 NA
82 hsa-miR-194-5p OSTM1 0.47 0 -0.53 0 MirTarget -0.15 0 NA
83 hsa-miR-194-5p PAFAH1B1 0.47 0 -0.55 0 miRNATAP -0.12 0 NA
84 hsa-miR-194-5p PARVA 0.47 0 -0.98 0 MirTarget -0.17 0 NA
85 hsa-miR-194-5p PER3 0.47 0 -1.22 0 miRNATAP -0.16 0.00031 NA
86 hsa-miR-194-5p PGAP1 0.47 0 -1.32 0 mirMAP -0.18 0.00031 NA
87 hsa-miR-194-5p PJA2 0.47 0 -0.86 0 MirTarget -0.19 0 NA
88 hsa-miR-194-5p PKD2 0.47 0 -1.64 0 miRNATAP -0.31 0 NA
89 hsa-miR-194-5p PLXDC1 0.47 0 -0.18 0.06459 mirMAP -0.23 0 NA
90 hsa-miR-194-5p PPFIBP1 0.47 0 -0.74 0 MirTarget -0.21 0 NA
91 hsa-miR-194-5p PPP1R12B 0.47 0 -2.24 0 mirMAP -0.27 0 NA
92 hsa-miR-194-5p PPP3CA 0.47 0 -0.54 0 MirTarget -0.13 0.0003 NA
93 hsa-miR-194-5p PRICKLE2 0.47 0 -1.42 0 miRNATAP -0.29 0 NA
94 hsa-miR-194-5p PRKCA 0.47 0 -1.71 0 mirMAP -0.19 0.00058 NA
95 hsa-miR-194-5p PTPN13 0.47 0 -0.81 0 miRNAWalker2 validate; miRTarBase -0.21 0.00033 NA
96 hsa-miR-194-5p PTPRD 0.47 0 0.15 0.42781 miRNATAP -0.27 0.00024 NA
97 hsa-miR-194-5p RAB11FIP2 0.47 0 -0.94 0 MirTarget; miRNATAP -0.16 0 NA
98 hsa-miR-194-5p RAB6B 0.47 0 -1.38 0 miRNATAP -0.11 0.03238 NA
99 hsa-miR-194-5p RBMS2 0.47 0 -1.23 0 mirMAP -0.15 0 NA
100 hsa-miR-194-5p REV3L 0.47 0 -1.33 0 miRNATAP -0.12 0.00392 NA
101 hsa-miR-194-5p RICTOR 0.47 0 -0.57 0 MirTarget -0.11 0.00082 NA
102 hsa-miR-194-5p RNF125 0.47 0 -1.57 0 MirTarget -0.14 0.00175 NA
103 hsa-miR-194-5p RNF152 0.47 0 -0.11 0.36917 mirMAP -0.12 0.01081 NA
104 hsa-miR-194-5p RRAS2 0.47 0 -1.34 0 MirTarget -0.12 0.01723 NA
105 hsa-miR-194-5p SALL1 0.47 0 -0.35 0.07463 MirTarget; miRNATAP -0.33 1.0E-5 NA
106 hsa-miR-194-5p SAMD4A 0.47 0 -1.8 0 miRNATAP -0.23 0 NA
107 hsa-miR-194-5p SAMD8 0.47 0 -1.03 0 MirTarget -0.11 0.01161 NA
108 hsa-miR-194-5p SATB1 0.47 0 -1.56 0 miRNATAP -0.15 0.00728 NA
109 hsa-miR-194-5p SEMA5A 0.47 0 -1.71 0 mirMAP -0.36 0 NA
110 hsa-miR-194-5p SESTD1 0.47 0 -0.83 0 mirMAP -0.17 0 NA
111 hsa-miR-194-5p SLC1A3 0.47 0 -1.29 0 MirTarget -0.26 0 NA
112 hsa-miR-194-5p SLC25A27 0.47 0 -2.61 0 MirTarget -0.18 0.01585 NA
113 hsa-miR-194-5p SLC2A3 0.47 0 -0.73 0 miRNATAP -0.13 0.0048 NA
114 hsa-miR-194-5p SLC5A3 0.47 0 -0.73 0 mirMAP -0.11 0.00735 NA
115 hsa-miR-194-5p SLK 0.47 0 -0.57 0 MirTarget -0.11 0.00024 NA
116 hsa-miR-194-5p SNX29 0.47 0 -0.6 0 miRNATAP -0.14 0 NA
117 hsa-miR-194-5p SOCS2 0.47 0 -1.86 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.0001 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival
118 hsa-miR-194-5p SOX5 0.47 0 -2.72 0 miRNAWalker2 validate; miRTarBase -0.21 0.01499 NA
119 hsa-miR-194-5p SPOCK3 0.47 0 -2.98 0 miRNATAP -0.36 0.00068 NA
120 hsa-miR-194-5p SPRED1 0.47 0 -0.74 0 miRNATAP -0.14 8.0E-5 NA
121 hsa-miR-194-5p STAT5B 0.47 0 -1.27 0 miRNATAP -0.12 0.00012 NA
122 hsa-miR-194-5p TAOK1 0.47 0 -1.03 0 miRNATAP -0.19 0.01211 NA
123 hsa-miR-194-5p TDRD9 0.47 0 -1.31 0 MirTarget -0.4 0.0001 NA
124 hsa-miR-194-5p TEAD1 0.47 0 -1.4 0 MirTarget -0.17 4.0E-5 NA
125 hsa-miR-194-5p TJP1 0.47 0 -0.77 0 miRNATAP -0.14 0 NA
126 hsa-miR-194-5p TLN2 0.47 0 -1.84 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.2 0 NA
127 hsa-miR-194-5p TMEM200A 0.47 0 -0.09 0.45872 MirTarget -0.28 0 NA
128 hsa-miR-194-5p TMEM26 0.47 0 -0.28 0.22894 MirTarget -0.27 0.00217 NA
129 hsa-miR-194-5p TMEM43 0.47 0 -0.76 0 MirTarget; miRNATAP -0.11 0 NA
130 hsa-miR-194-5p TRIM23 0.47 0 -0.68 0 MirTarget -0.15 0 26221053 Transcripts encoding tripartite motif containing 23 TRIM23 a ubiquitin ligase involved in NF-κB activation and chromosome 21 open reading frame 91 C21ORF91 a protein of unknown function were identified as direct targets of miR-194 in HCC cells; knocking down either protein decreased the activity of a luciferase NF-κB reporter
131 hsa-miR-194-5p WTIP 0.47 0 -0.67 0 mirMAP -0.11 0.02739 NA
132 hsa-miR-194-5p ZEB1 0.47 0 -1.2 0 miRNATAP -0.32 0 NA
133 hsa-miR-194-5p ZFHX3 0.47 0 -0.35 0.00018 MirTarget; miRNATAP -0.16 2.0E-5 NA
134 hsa-miR-194-5p ZFHX4 0.47 0 -1.53 0 MirTarget; miRNATAP -0.36 0 NA
135 hsa-miR-194-5p ZNF25 0.47 0 -0.92 0 miRNATAP -0.14 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 27 1426 8.624e-07 0.004013
2 POSITIVE REGULATION OF AXON EXTENSION 5 36 4.145e-06 0.007852
3 POSITIVE REGULATION OF GROWTH 10 238 5.062e-06 0.007852
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 16 629 5.45e-06 0.005063
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 22 1199 1.702e-05 0.00527
3 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 11 328 1.433e-05 0.00527
4 ENZYME BINDING 27 1737 3.292e-05 0.007647
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 22 1151 9.008e-06 0.005261

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Wnt_signaling_pathway_hsa04310 6 146 0.0004737 0.02463
2 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.0009665 0.02513
3 Focal_adhesion_hsa04510 6 199 0.002338 0.03417
4 ErbB_signaling_pathway_hsa04012 4 85 0.002635 0.03417
5 mTOR_signaling_pathway_hsa04150 5 151 0.003626 0.03417
6 Hippo_signaling_pathway_hsa04390 5 154 0.003943 0.03417
7 MAPK_signaling_pathway_hsa04010 6 295 0.01511 0.1123
8 VEGF_signaling_pathway_hsa04370 2 59 0.0603 0.3609
9 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.06804 0.3609
10 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.07514 0.3609
11 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.07635 0.3609
12 Cellular_senescence_hsa04218 3 160 0.09423 0.4083
13 Gap_junction_hsa04540 2 88 0.1192 0.4657
14 Calcium_signaling_pathway_hsa04020 3 182 0.1254 0.4657
15 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.1442 0.4761
16 HIF_1_signaling_pathway_hsa04066 2 100 0.1465 0.4761
17 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.1662 0.5084
18 Oocyte_meiosis_hsa04114 2 124 0.2042 0.5898
19 Apelin_signaling_pathway_hsa04371 2 137 0.2364 0.6469
20 Jak_STAT_signaling_pathway_hsa04630 2 162 0.2988 0.7461
21 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.3013 0.7461
22 Tight_junction_hsa04530 2 170 0.3187 0.7533
23 Rap1_signaling_pathway_hsa04015 2 206 0.406 0.822
24 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.4252 0.822
25 Ras_signaling_pathway_hsa04014 2 232 0.4657 0.8649
26 Endocytosis_hsa04144 2 244 0.4921 0.8823

Quest ID: a0ed0d28de66aba0236d8ad041ea0c33