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show label of nodes with degree >=

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p RNF180 0.6 0.01023 -2.77 0 miRanda -0.24 0.0024 NA
2 hsa-miR-142-5p RNF180 1.18 0.00182 -2.77 0 mirMAP -0.13 0.00817 NA
3 hsa-miR-25-3p RNF180 1.36 0 -2.77 0 miRNATAP -0.49 0 NA
4 hsa-miR-32-5p RNF180 2.34 0 -2.77 0 miRNATAP -0.48 0 NA
5 hsa-miR-330-3p RNF180 0.88 0.00074 -2.77 0 miRNATAP -0.34 0 NA
6 hsa-miR-335-3p RNF180 3.09 0 -2.77 0 mirMAP -0.22 0 NA
7 hsa-miR-339-5p RNF180 2.69 0 -2.77 0 miRanda -0.35 0 NA
8 hsa-miR-34c-3p RNF180 2.41 0 -2.77 0 miRNATAP -0.24 0 NA
9 hsa-miR-429 RNF180 4.49 0 -2.77 0 miRanda; miRNATAP -0.17 0 NA
10 hsa-miR-454-3p RNF180 2.47 0 -2.77 0 miRNATAP -0.58 0 NA
11 hsa-miR-576-5p RNF180 2.2 0 -2.77 0 mirMAP -0.63 0 NA
12 hsa-miR-590-3p RNF180 2.59 0 -2.77 0 miRanda; mirMAP; miRNATAP -0.53 0 NA
13 hsa-miR-590-5p RNF180 3.18 0 -2.77 0 miRanda -0.54 0 NA
14 hsa-miR-7-1-3p RNF180 1.85 0 -2.77 0 mirMAP -0.49 0 NA
15 hsa-miR-92a-3p RNF180 2.06 0 -2.77 0 miRNATAP -0.67 0 NA
16 hsa-miR-92b-3p RNF180 1.2 0 -2.77 0 miRNATAP -0.23 0.00077 NA
17 hsa-miR-944 RNF180 2.91 0 -2.77 0 mirMAP -0.22 0 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MAGI2-AS3 hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 12 RNF180 Sponge network -2.414 0 -2.772 0 0.588
2 MIR143HG hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 15 RNF180 Sponge network -4.237 0 -2.772 0 0.513
3 ADAMTS9-AS1 hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 14 RNF180 Sponge network -7.614 0 -2.772 0 0.492
4 LINC00654 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-339-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-944 12 RNF180 Sponge network -1.448 0.00044 -2.772 0 0.466
5 HAND2-AS1 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 14 RNF180 Sponge network -5.605 0 -2.772 0 0.429
6 TPTEP1 hsa-miR-142-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p 12 RNF180 Sponge network -2.267 2.0E-5 -2.772 0 0.427
7 RP11-531A24.5 hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 12 RNF180 Sponge network -1.752 0 -2.772 0 0.418
8 RP11-166D19.1 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 16 RNF180 Sponge network -3.855 0 -2.772 0 0.415
9 LINC00702 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p 13 RNF180 Sponge network -2.704 0 -2.772 0 0.401
10 AF131217.1 hsa-miR-125a-5p;hsa-miR-142-5p;hsa-miR-25-3p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-944 10 RNF180 Sponge network -5.31 0 -2.772 0 0.387
11 PWAR6 hsa-miR-142-5p;hsa-miR-25-3p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-944 10 RNF180 Sponge network -2.542 0 -2.772 0 0.375
12 SNHG14 hsa-miR-142-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-339-5p;hsa-miR-34c-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p 12 RNF180 Sponge network -2.055 0 -2.772 0 0.368
13 DNM3OS hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-330-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-944 10 RNF180 Sponge network -2.298 1.0E-5 -2.772 0 0.343
14 TBX5-AS1 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-576-5p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-944 10 RNF180 Sponge network -2.557 2.0E-5 -2.772 0 0.321
15 PART1 hsa-miR-142-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-34c-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-92b-3p 12 RNF180 Sponge network -3.06 7.0E-5 -2.772 0 0.302
16 AC093627.10 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-339-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p 11 RNF180 Sponge network -2.338 8.0E-5 -2.772 0 0.296
17 NR2F1-AS1 hsa-miR-125a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-339-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-944 11 RNF180 Sponge network -1.881 0 -2.772 0 0.288

Quest ID: a2e170018ca4e09d2b2c0250185bb3b2