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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-183-5p ABAT 6.62 0 0.06 0.94069 MirTarget -0.16 0.00206 NA
2 hsa-let-7a-3p ABCA1 0.83 0.04681 0.72 0.28064 mirMAP; miRNATAP -0.23 0.01252 NA
3 hsa-miR-183-5p ABCA1 6.62 0 0.72 0.28064 MirTarget; miRNATAP -0.15 0.00066 26935154 MiR 183 functions as an oncogene by targeting ABCA1 in colon cancer; We found that miR-183 targets the 3'UTR of ABCA1 mRNA; Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells; Thus we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer
4 hsa-let-7a-3p ABCA5 0.83 0.04681 0.37 0.51209 mirMAP -0.2 0.01113 NA
5 hsa-let-7f-1-3p ABCA5 1.62 0.00069 0.37 0.51209 mirMAP -0.17 0.01029 NA
6 hsa-miR-181b-5p ABCA5 1.11 0.02734 0.37 0.51209 mirMAP -0.19 0.00348 NA
7 hsa-miR-183-5p ABCA8 6.62 0 -8.05 0 MirTarget -0.32 0.00107 NA
8 hsa-let-7a-3p ABCC9 0.83 0.04681 -5.85 0 mirMAP -0.47 0.00079 NA
9 hsa-let-7f-1-3p ABCC9 1.62 0.00069 -5.85 0 mirMAP -0.66 0 NA
10 hsa-let-7a-3p ABCD2 0.83 0.04681 -2.82 0.00416 mirMAP -0.39 0.00433 NA
11 hsa-let-7f-1-3p ABCD3 1.62 0.00069 0.36 0.31447 MirTarget -0.11 0.01345 NA
12 hsa-miR-181b-5p ABI1 1.11 0.02734 0.65 0.07307 MirTarget -0.2 0 NA
13 hsa-miR-181d-5p ABI1 -0.53 0.32526 0.65 0.07307 MirTarget -0.17 1.0E-5 NA
14 hsa-miR-224-5p ABI2 4.27 1.0E-5 -1.23 0.00252 mirMAP -0.1 3.0E-5 NA
15 hsa-let-7a-3p ABI3BP 0.83 0.04681 -5.04 2.0E-5 miRNATAP -0.55 0.00098 NA
16 hsa-miR-181b-5p ABI3BP 1.11 0.02734 -5.04 2.0E-5 miRNATAP -0.29 0.03119 NA
17 hsa-let-7a-3p ABLIM1 0.83 0.04681 -0.15 0.81715 mirMAP -0.18 0.04197 NA
18 hsa-let-7f-1-3p ABLIM1 1.62 0.00069 -0.15 0.81715 mirMAP -0.16 0.04285 NA
19 hsa-miR-181b-5p ACAP2 1.11 0.02734 0.49 0.26503 MirTarget; miRNATAP -0.16 0.00114 NA
20 hsa-miR-181b-5p ACSL1 1.11 0.02734 -0.26 0.66804 MirTarget -0.27 0.00011 NA
21 hsa-miR-181d-5p ACSL1 -0.53 0.32526 -0.26 0.66804 MirTarget -0.14 0.03075 NA
22 hsa-miR-224-5p ACSL4 4.27 1.0E-5 -0.89 0.13062 MirTarget -0.11 0.00143 NA
23 hsa-miR-181b-5p ACSS1 1.11 0.02734 -0.48 0.54243 mirMAP -0.2 0.02708 NA
24 hsa-miR-15a-5p ACSS2 2.05 0 0.06 0.8809 MirTarget -0.12 0.01889 NA
25 hsa-miR-224-5p ACTR3B 4.27 1.0E-5 -0.49 0.29937 MirTarget -0.13 0 NA
26 hsa-miR-181b-5p ACVR1C 1.11 0.02734 1.69 0.1187 miRNATAP -0.31 0.01166 NA
27 hsa-let-7f-1-3p ACVR2B 1.62 0.00069 -0.47 0.3473 MirTarget -0.2 0.00088 NA
28 hsa-miR-139-3p ADAM11 -2.55 0.00045 -2.44 0.00581 MirTarget -0.14 0.04914 NA
29 hsa-miR-224-5p ADAM22 4.27 1.0E-5 -1.69 0.18073 MirTarget -0.21 0.00458 NA
30 hsa-let-7f-1-3p ADAM23 1.62 0.00069 -1.16 0.57179 mirMAP -0.54 0.02829 NA
31 hsa-miR-224-5p ADAMTS2 4.27 1.0E-5 -2.49 0.0191 mirMAP -0.13 0.0327 NA
32 hsa-miR-15a-5p ADAMTS3 2.05 0 -3.48 0.00158 miRNATAP -0.46 0.00134 NA
33 hsa-let-7a-3p ADAMTS5 0.83 0.04681 -6.22 0 mirMAP -0.41 0.00244 NA
34 hsa-let-7f-1-3p ADAMTS5 1.62 0.00069 -6.22 0 mirMAP -0.62 0 NA
35 hsa-miR-15a-5p ADAMTS5 2.05 0 -6.22 0 miRNATAP -0.54 2.0E-5 NA
36 hsa-let-7f-1-3p ADAMTS9 1.62 0.00069 -3.73 2.0E-5 mirMAP -0.49 0 NA
37 hsa-miR-181b-5p ADAMTSL1 1.11 0.02734 -5.88 0 miRNATAP -0.33 0.008 NA
38 hsa-miR-15a-5p ADAMTSL3 2.05 0 -3.54 0.01144 MirTarget -0.37 0.04793 NA
39 hsa-miR-224-5p ADCYAP1 4.27 1.0E-5 -5.14 0.00012 mirMAP -0.33 3.0E-5 NA
40 hsa-let-7a-3p ADD3 0.83 0.04681 0.29 0.59978 mirMAP; miRNATAP -0.17 0.02915 NA
41 hsa-let-7f-1-3p ADD3 1.62 0.00069 0.29 0.59978 mirMAP -0.15 0.02744 NA
42 hsa-miR-181d-5p ADM -0.53 0.32526 1.98 0.02456 MirTarget -0.19 0.04514 NA
43 hsa-let-7f-1-3p AFF2 1.62 0.00069 -0.5 0.77135 mirMAP -0.75 0.00027 NA
44 hsa-let-7a-3p AFF3 0.83 0.04681 -4.69 0 MirTarget -0.51 0.0001 NA
45 hsa-let-7f-1-3p AFF3 1.62 0.00069 -4.69 0 MirTarget -0.74 0 NA
46 hsa-miR-224-5p AFF3 4.27 1.0E-5 -4.69 0 MirTarget -0.27 0 NA
47 hsa-let-7a-3p AFF4 0.83 0.04681 -0.54 0.12416 MirTarget; mirMAP -0.14 0.0028 NA
48 hsa-let-7f-1-3p AFF4 1.62 0.00069 -0.54 0.12416 MirTarget; mirMAP -0.12 0.00488 NA
49 hsa-miR-181b-5p AFTPH 1.11 0.02734 0.31 0.22619 MirTarget; miRNATAP -0.11 9.0E-5 NA
50 hsa-miR-181b-5p AGFG2 1.11 0.02734 -1.25 0.00413 mirMAP -0.14 0.00331 NA
51 hsa-miR-183-5p AJAP1 6.62 0 -2.49 0.05813 MirTarget -0.24 0.00594 NA
52 hsa-let-7a-3p AKAP11 0.83 0.04681 -0.61 0.12508 mirMAP -0.25 0 NA
53 hsa-let-7f-1-3p AKAP11 1.62 0.00069 -0.61 0.12508 mirMAP -0.15 0.00129 NA
54 hsa-let-7a-3p AKAP9 0.83 0.04681 0.02 0.95129 MirTarget -0.17 0.00078 NA
55 hsa-let-7f-1-3p AKAP9 1.62 0.00069 0.02 0.95129 MirTarget -0.13 0.00367 NA
56 hsa-miR-181b-5p AKR1C1 1.11 0.02734 0.79 0.6259 mirMAP -0.56 0.00205 NA
57 hsa-miR-15a-5p AKT3 2.05 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00021 NA
58 hsa-let-7f-1-3p ALDH5A1 1.62 0.00069 0.43 0.4556 mirMAP -0.22 0.00146 NA
59 hsa-let-7f-1-3p ALDH7A1 1.62 0.00069 -0.55 0.61727 mirMAP -0.27 0.04228 NA
60 hsa-let-7f-1-3p AMN1 1.62 0.00069 -1.15 0.01554 mirMAP -0.24 2.0E-5 NA
61 hsa-let-7a-3p AMOT 0.83 0.04681 -1.94 0.20701 mirMAP -0.59 0.00568 NA
62 hsa-let-7f-1-3p AMOT 1.62 0.00069 -1.94 0.20701 mirMAP -1.03 0 NA
63 hsa-miR-224-5p AMZ1 4.27 1.0E-5 -1.49 0.10286 mirMAP -0.13 0.0164 NA
64 hsa-miR-194-5p ANGPTL1 0.69 0.52314 -8.04 0 MirTarget -0.15 0.02902 NA
65 hsa-miR-15a-5p ANK2 2.05 0 -5.41 0 MirTarget; miRNATAP -0.62 2.0E-5 NA
66 hsa-let-7a-3p ANK3 0.83 0.04681 -0.05 0.94538 MirTarget -0.21 0.02601 NA
67 hsa-let-7f-1-3p ANK3 1.62 0.00069 -0.05 0.94538 MirTarget -0.28 0.0005 NA
68 hsa-miR-181b-5p ANKMY1 1.11 0.02734 -0.53 0.1888 mirMAP -0.19 3.0E-5 NA
69 hsa-miR-181b-5p ANKRD12 1.11 0.02734 -0.49 0.18892 mirMAP -0.16 0.00019 NA
70 hsa-miR-224-5p ANKRD45 4.27 1.0E-5 -2.8 0.03183 MirTarget -0.3 8.0E-5 NA
71 hsa-let-7a-3p ANKS1B 0.83 0.04681 -3.57 0.00191 miRNATAP -0.42 0.00925 NA
72 hsa-miR-181b-5p ANO1 1.11 0.02734 0.03 0.97495 MirTarget; miRNATAP -0.57 0 NA
73 hsa-let-7a-3p ANO4 0.83 0.04681 -4.46 0.00135 MirTarget; miRNATAP -0.62 0.00143 NA
74 hsa-let-7f-1-3p ANO4 1.62 0.00069 -4.46 0.00135 MirTarget -0.48 0.00412 NA
75 hsa-let-7a-3p ANO5 0.83 0.04681 -4.62 0.00063 mirMAP -0.71 0.00016 NA
76 hsa-let-7f-1-3p ANO5 1.62 0.00069 -4.62 0.00063 mirMAP -0.79 0 NA
77 hsa-miR-181b-5p ANXA11 1.11 0.02734 0 0.98997 MirTarget; mirMAP -0.13 0.00299 NA
78 hsa-let-7a-3p APC 0.83 0.04681 -0.08 0.84234 mirMAP -0.12 0.02517 NA
79 hsa-let-7f-1-3p APC 1.62 0.00069 -0.08 0.84234 mirMAP -0.11 0.02128 NA
80 hsa-let-7a-3p APPBP2 0.83 0.04681 -0.69 0.0128 mirMAP; miRNATAP -0.12 0.00175 NA
81 hsa-let-7f-1-3p APPL1 1.62 0.00069 -0.45 0.2173 MirTarget; mirMAP -0.12 0.00459 NA
82 hsa-miR-15a-5p AR 2.05 0 -4.57 0.00169 mirMAP; miRNATAP -0.77 5.0E-5 NA
83 hsa-miR-181b-5p ARF6 1.11 0.02734 0.97 0.00132 MirTarget -0.14 3.0E-5 NA
84 hsa-miR-181d-5p ARF6 -0.53 0.32526 0.97 0.00132 MirTarget -0.14 1.0E-5 NA
85 hsa-let-7a-3p ARFGEF2 0.83 0.04681 0.39 0.33431 miRNATAP -0.2 0.00024 NA
86 hsa-miR-181b-5p ARFGEF2 1.11 0.02734 0.39 0.33431 MirTarget; miRNATAP -0.15 0.00063 NA
87 hsa-let-7a-3p ARGLU1 0.83 0.04681 0.31 0.38739 mirMAP -0.14 0.00472 NA
88 hsa-let-7a-3p ARHGAP12 0.83 0.04681 -0.05 0.91839 miRNATAP -0.23 0.00019 NA
89 hsa-miR-181b-5p ARHGAP19 1.11 0.02734 -0.22 0.58517 mirMAP -0.14 0.00256 NA
90 hsa-let-7a-3p ARHGAP20 0.83 0.04681 -3.56 0.00051 MirTarget; miRNATAP -0.28 0.04657 NA
91 hsa-let-7f-1-3p ARHGAP20 1.62 0.00069 -3.56 0.00051 MirTarget -0.26 0.03518 NA
92 hsa-miR-15a-5p ARHGAP20 2.05 0 -3.56 0.00051 MirTarget; miRNATAP -0.63 0 NA
93 hsa-let-7f-1-3p ARHGAP28 1.62 0.00069 -2.52 0.04263 mirMAP -0.56 0.00017 NA
94 hsa-let-7a-3p ARHGAP32 0.83 0.04681 0.91 0.12572 mirMAP -0.26 0.0016 NA
95 hsa-miR-181b-5p ARHGAP32 1.11 0.02734 0.91 0.12572 mirMAP -0.27 4.0E-5 NA
96 hsa-miR-181b-5p ARHGAP5 1.11 0.02734 0.28 0.45998 mirMAP -0.11 0.00714 NA
97 hsa-miR-183-5p ARHGAP6 6.62 0 -5.45 0 MirTarget; miRNATAP -0.15 0.01468 NA
98 hsa-miR-181b-5p ARHGEF3 1.11 0.02734 -1 0.016 MirTarget -0.11 0.01917 NA
99 hsa-miR-181d-5p ARHGEF3 -0.53 0.32526 -1 0.016 MirTarget -0.14 0.00173 NA
100 hsa-miR-181b-5p ARHGEF7 1.11 0.02734 -0.35 0.21327 MirTarget; miRNATAP -0.11 0.00048 NA
101 hsa-let-7a-3p ARID4A 0.83 0.04681 -0.65 0.04997 MirTarget; miRNATAP -0.17 0.00016 NA
102 hsa-let-7f-1-3p ARID4A 1.62 0.00069 -0.65 0.04997 MirTarget -0.14 0.00034 NA
103 hsa-let-7a-3p ARID5B 0.83 0.04681 -2.21 0 miRNATAP -0.13 0.03163 NA
104 hsa-let-7f-1-3p ARL10 1.62 0.00069 -0.75 0.35282 mirMAP -0.2 0.04331 NA
105 hsa-miR-15a-5p ARL2 2.05 0 -1.43 0.00052 MirTarget; miRNATAP -0.21 7.0E-5 NA
106 hsa-miR-15a-5p ARMCX2 2.05 0 -2.7 0.00294 MirTarget; miRNATAP -0.3 0.01228 NA
107 hsa-miR-224-5p ARMCX2 4.27 1.0E-5 -2.7 0.00294 MirTarget -0.21 6.0E-5 NA
108 hsa-miR-181b-5p ARRDC4 1.11 0.02734 -0.92 0.1366 miRNATAP -0.22 0.00128 NA
109 hsa-let-7a-3p ARSB 0.83 0.04681 -0.81 0.05394 mirMAP -0.23 5.0E-5 NA
110 hsa-let-7f-1-3p ARSB 1.62 0.00069 -0.81 0.05394 mirMAP -0.17 0.00085 NA
111 hsa-let-7a-3p ASAH1 0.83 0.04681 -0.58 0.14897 MirTarget -0.21 0.00013 NA
112 hsa-let-7f-1-3p ASAH1 1.62 0.00069 -0.58 0.14897 MirTarget -0.2 2.0E-5 NA
113 hsa-miR-194-5p ASAP1 0.69 0.52314 -0.15 0.71428 MirTarget; miRNATAP -0.13 0 NA
114 hsa-let-7a-3p ASAP2 0.83 0.04681 0.25 0.58302 MirTarget; miRNATAP -0.16 0.01273 NA
115 hsa-miR-181b-5p ASB13 1.11 0.02734 -0.33 0.38533 miRNAWalker2 validate -0.16 0.00012 NA
116 hsa-miR-15a-5p ASTN1 2.05 0 -4.82 0.0004 MirTarget -0.82 0 NA
117 hsa-let-7f-1-3p ASTN2 1.62 0.00069 -1.99 0.06339 mirMAP -0.44 0.00059 NA
118 hsa-let-7a-3p ASXL2 0.83 0.04681 0.95 0.22717 mirMAP; miRNATAP -0.34 0.00164 NA
119 hsa-let-7a-3p ATE1 0.83 0.04681 0.43 0.49372 mirMAP -0.2 0.02098 NA
120 hsa-miR-181b-5p ATE1 1.11 0.02734 0.43 0.49372 mirMAP -0.19 0.00584 NA
121 hsa-let-7a-3p ATF2 0.83 0.04681 0.26 0.63833 MirTarget; mirMAP; miRNATAP -0.15 0.04116 NA
122 hsa-let-7a-3p ATG2B 0.83 0.04681 -0.44 0.24501 MirTarget -0.15 0.00445 NA
123 hsa-let-7f-1-3p ATG2B 1.62 0.00069 -0.44 0.24501 MirTarget -0.15 0.00055 NA
124 hsa-miR-183-5p ATP10B 6.62 0 3.53 0.02777 MirTarget -0.43 7.0E-5 NA
125 hsa-miR-181b-5p ATP11B 1.11 0.02734 0.87 0.09528 MirTarget -0.21 0.00026 NA
126 hsa-miR-181d-5p ATP11B -0.53 0.32526 0.87 0.09528 MirTarget -0.2 0.00032 NA
127 hsa-miR-224-5p ATP8A1 4.27 1.0E-5 -1.21 0.1241 MirTarget -0.2 2.0E-5 NA
128 hsa-miR-181b-5p ATP8B1 1.11 0.02734 0.93 0.09129 miRNATAP -0.32 0 NA
129 hsa-miR-194-5p ATP8B4 0.69 0.52314 -2.31 0.00034 MirTarget -0.12 0.00043 NA
130 hsa-let-7a-3p ATRX 0.83 0.04681 -0.47 0.18181 MirTarget; miRNATAP -0.13 0.00771 NA
131 hsa-let-7f-1-3p ATRX 1.62 0.00069 -0.47 0.18181 MirTarget -0.16 0.00018 NA
132 hsa-miR-181b-5p ATXN7 1.11 0.02734 0.19 0.62797 MirTarget -0.11 0.01048 NA
133 hsa-miR-15a-5p ATXN7L1 2.05 0 -0.2 0.58676 miRNATAP -0.11 0.02655 NA
134 hsa-miR-15a-5p ATXN7L3B 2.05 0 -0.63 0.07776 MirTarget -0.15 0.00095 NA
135 hsa-let-7a-3p AXIN2 0.83 0.04681 -3.82 0.00033 miRNATAP -0.49 0.00085 NA
136 hsa-miR-15a-5p AXIN2 2.05 0 -3.82 0.00033 MirTarget; miRNATAP -0.55 8.0E-5 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy
137 hsa-miR-181b-5p B3GALT5 1.11 0.02734 0.39 0.83072 MirTarget -0.64 0.00217 NA
138 hsa-miR-181b-5p B3GNT5 1.11 0.02734 2.46 0.00043 MirTarget -0.2 0.01035 NA
139 hsa-miR-181d-5p B3GNT5 -0.53 0.32526 2.46 0.00043 MirTarget -0.28 0.00014 NA
140 hsa-miR-181b-5p B4GALT4 1.11 0.02734 0.59 0.30576 mirMAP -0.14 0.03298 NA
141 hsa-miR-15a-5p BACE1 2.05 0 -1.41 0.00094 miRNAWalker2 validate; miRNATAP -0.18 0.00108 NA
142 hsa-miR-15a-5p BACH2 2.05 0 -2.73 0.00174 MirTarget; miRNATAP -0.3 0.01008 NA
143 hsa-let-7a-3p BCAS1 0.83 0.04681 -0.07 0.96835 mirMAP -0.89 0.00012 NA
144 hsa-let-7f-1-3p BCAS1 1.62 0.00069 -0.07 0.96835 mirMAP -0.84 2.0E-5 NA
145 hsa-miR-183-5p BCL11B 6.62 0 2.87 0.00737 miRNAWalker2 validate; miRNATAP -0.2 0.00496 NA
146 hsa-miR-181b-5p BCL6 1.11 0.02734 -0.53 0.26262 miRNATAP -0.21 7.0E-5 NA
147 hsa-miR-181b-5p BCL6B 1.11 0.02734 -3.36 0 MirTarget -0.19 0.01291 NA
148 hsa-miR-181d-5p BCL6B -0.53 0.32526 -3.36 0 MirTarget -0.22 0.00155 NA
149 hsa-let-7a-3p BDP1 0.83 0.04681 0.05 0.90095 MirTarget; mirMAP -0.16 0.00465 NA
150 hsa-let-7f-1-3p BDP1 1.62 0.00069 0.05 0.90095 MirTarget; mirMAP -0.13 0.00598 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN PHOSPHORYLATION 118 944 1.228e-16 5.716e-13
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 174 1672 4.441e-16 9.565e-13
3 NEUROGENESIS 153 1402 6.167e-16 9.565e-13
4 TISSUE DEVELOPMENT 161 1518 1.262e-15 1.468e-12
5 CELL DEVELOPMENT 152 1426 5.91e-15 5.5e-12
6 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 118 1008 1.523e-14 1.181e-11
7 PHOSPHORYLATION 135 1228 2.294e-14 1.525e-11
8 RESPONSE TO ENDOGENOUS STIMULUS 149 1450 2.271e-13 1.288e-10
9 REGULATION OF GTPASE ACTIVITY 87 673 2.491e-13 1.288e-10
10 REGULATION OF CELL DIFFERENTIATION 151 1492 5.191e-13 2.013e-10
11 CARDIOVASCULAR SYSTEM DEVELOPMENT 96 788 5.039e-13 2.013e-10
12 CIRCULATORY SYSTEM DEVELOPMENT 96 788 5.039e-13 2.013e-10
13 ORGAN MORPHOGENESIS 100 841 7.106e-13 2.543e-10
14 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 87 689 9.32e-13 3.098e-10
15 EPITHELIUM DEVELOPMENT 108 945 1.035e-12 3.21e-10
16 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 113 1021 2.428e-12 7.061e-10
17 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 129 1275 3.293e-11 9.013e-09
18 POSITIVE REGULATION OF MOLECULAR FUNCTION 166 1791 4.515e-11 1.167e-08
19 INTRACELLULAR SIGNAL TRANSDUCTION 150 1572 5.621e-11 1.357e-08
20 PEPTIDYL TYROSINE MODIFICATION 36 186 5.834e-11 1.357e-08
21 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 118 1142 6.737e-11 1.493e-08
22 NEURON DIFFERENTIATION 97 874 8.38e-11 1.772e-08
23 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 87 750 8.87e-11 1.794e-08
24 CENTRAL NERVOUS SYSTEM DEVELOPMENT 96 872 1.64e-10 3.18e-08
25 POSITIVE REGULATION OF GENE EXPRESSION 159 1733 2.669e-10 4.967e-08
26 TUBE DEVELOPMENT 69 552 3.583e-10 6.263e-08
27 REGULATION OF CELLULAR COMPONENT MOVEMENT 87 771 3.634e-10 6.263e-08
28 REGULATION OF CELL DEVELOPMENT 92 836 4.126e-10 6.856e-08
29 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 166 1848 5.032e-10 7.805e-08
30 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 175 1977 4.902e-10 7.805e-08
31 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 107 1036 5.793e-10 8.423e-08
32 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 107 1036 5.793e-10 8.423e-08
33 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 152 1656 6.857e-10 9.389e-08
34 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 161 1784 6.861e-10 9.389e-08
35 REGULATION OF TRANSPORT 162 1804 8.654e-10 1.15e-07
36 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 100 957 1.186e-09 1.533e-07
37 UROGENITAL SYSTEM DEVELOPMENT 45 299 1.503e-09 1.89e-07
38 CELLULAR COMPONENT MORPHOGENESIS 95 900 1.887e-09 2.311e-07
39 BIOLOGICAL ADHESION 105 1032 1.948e-09 2.324e-07
40 LOCOMOTION 111 1114 2.139e-09 2.489e-07
41 REGULATION OF PHOSPHORUS METABOLIC PROCESS 147 1618 2.736e-09 3.105e-07
42 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 160 1805 2.835e-09 3.141e-07
43 POSITIVE REGULATION OF CATALYTIC ACTIVITY 139 1518 4.782e-09 5.175e-07
44 VASCULATURE DEVELOPMENT 59 469 5.467e-09 5.781e-07
45 TUBE MORPHOGENESIS 46 323 5.959e-09 6.162e-07
46 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 101 1004 7.328e-09 7.412e-07
47 TISSUE MORPHOGENESIS 64 533 7.807e-09 7.729e-07
48 PROTEIN AUTOPHOSPHORYLATION 33 192 8.496e-09 8.235e-07
49 POSITIVE REGULATION OF HYDROLASE ACTIVITY 93 905 1.07e-08 1.015e-06
50 HEART DEVELOPMENT 58 466 1.09e-08 1.015e-06
51 BLOOD VESSEL MORPHOGENESIS 49 364 1.248e-08 1.139e-06
52 CELLULAR RESPONSE TO HORMONE STIMULUS 65 552 1.283e-08 1.148e-06
53 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 41 278 1.452e-08 1.274e-06
54 CELL MOTILITY 87 835 1.729e-08 1.463e-06
55 LOCALIZATION OF CELL 87 835 1.729e-08 1.463e-06
56 NEURON PROJECTION DEVELOPMENT 64 545 1.848e-08 1.518e-06
57 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 128 1395 1.86e-08 1.518e-06
58 REGULATION OF CELL PROJECTION ORGANIZATION 65 558 1.952e-08 1.566e-06
59 REGULATION OF CELL PROLIFERATION 134 1496 3.567e-08 2.813e-06
60 REGULATION OF HYDROLASE ACTIVITY 122 1327 3.724e-08 2.888e-06
61 MORPHOGENESIS OF AN EPITHELIUM 51 400 3.855e-08 2.94e-06
62 HEAD DEVELOPMENT 76 709 4.451e-08 3.34e-06
63 RESPONSE TO HORMONE 90 893 4.645e-08 3.431e-06
64 EMBRYO DEVELOPMENT 90 894 4.892e-08 3.502e-06
65 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 59 498 4.886e-08 3.502e-06
66 RESPONSE TO GROWTH FACTOR 57 475 5.301e-08 3.737e-06
67 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 60 513 5.972e-08 4.148e-06
68 CELL PROJECTION ORGANIZATION 90 902 7.367e-08 5.041e-06
69 REGULATION OF PROTEIN MODIFICATION PROCESS 147 1710 9.591e-08 6.468e-06
70 NEURON DEVELOPMENT 73 687 1.172e-07 7.792e-06
71 ACTIN FILAMENT BASED PROCESS 54 450 1.189e-07 7.793e-06
72 POSITIVE REGULATION OF CELL DIFFERENTIATION 83 823 1.539e-07 9.946e-06
73 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 81 799 1.757e-07 1.115e-05
74 REGULATION OF NEURON DIFFERENTIATION 62 554 1.774e-07 1.115e-05
75 REGULATION OF SYSTEM PROCESS 58 507 2.119e-07 1.315e-05
76 POSITIVE REGULATION OF CELL COMMUNICATION 133 1532 2.451e-07 1.5e-05
77 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 105 1135 2.66e-07 1.607e-05
78 NEGATIVE REGULATION OF CELL COMMUNICATION 109 1192 2.765e-07 1.65e-05
79 EMBRYONIC MORPHOGENESIS 60 539 3.365e-07 1.982e-05
80 MODULATION OF SYNAPTIC TRANSMISSION 40 301 3.795e-07 2.208e-05
81 METANEPHROS DEVELOPMENT 18 81 4.275e-07 2.447e-05
82 KIDNEY EPITHELIUM DEVELOPMENT 23 125 4.313e-07 2.447e-05
83 SINGLE ORGANISM BEHAVIOR 47 384 4.405e-07 2.47e-05
84 CELL PROLIFERATION 70 672 4.531e-07 2.51e-05
85 REGULATION OF MAPK CASCADE 69 660 4.795e-07 2.625e-05
86 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 51 437 6.268e-07 3.391e-05
87 CYTOSKELETON ORGANIZATION 82 838 6.386e-07 3.415e-05
88 REGULATION OF CELL DEATH 127 1472 6.57e-07 3.474e-05
89 MORPHOGENESIS OF A BRANCHING STRUCTURE 27 167 6.688e-07 3.497e-05
90 CELL JUNCTION ASSEMBLY 23 129 7.707e-07 3.985e-05
91 BEHAVIOR 57 516 8.482e-07 4.337e-05
92 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 14 53 8.835e-07 4.451e-05
93 REGULATION OF PHOSPHOLIPASE C ACTIVITY 12 39 8.896e-07 4.451e-05
94 SENSORY ORGAN DEVELOPMENT 55 493 9.689e-07 4.796e-05
95 POSITIVE REGULATION OF CELL DEVELOPMENT 53 472 1.251e-06 6.127e-05
96 POSITIVE REGULATION OF CELL PROLIFERATION 79 814 1.417e-06 6.867e-05
97 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 28 184 1.465e-06 6.954e-05
98 INOSITOL LIPID MEDIATED SIGNALING 22 124 1.452e-06 6.954e-05
99 METANEPHROS MORPHOGENESIS 10 28 1.563e-06 7.347e-05
100 REGULATION OF MEMBRANE POTENTIAL 42 343 1.769e-06 8.229e-05
101 REGULATION OF PHOSPHOLIPASE ACTIVITY 15 64 1.9e-06 8.754e-05
102 REGULATION OF EPITHELIAL CELL MIGRATION 26 166 1.983e-06 9.045e-05
103 REGULATION OF TRANSPORTER ACTIVITY 29 198 2.12e-06 9.576e-05
104 MUSCLE STRUCTURE DEVELOPMENT 49 432 2.356e-06 0.0001054
105 EPITHELIAL CELL DIFFERENTIATION 54 495 2.404e-06 0.0001065
106 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 26 168 2.494e-06 0.0001085
107 KIDNEY MORPHOGENESIS 17 82 2.486e-06 0.0001085
108 REGULATION OF VASCULATURE DEVELOPMENT 32 233 2.673e-06 0.0001152
109 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 38 303 3.069e-06 0.000131
110 NEGATIVE REGULATION OF CELL PROLIFERATION 65 643 3.244e-06 0.0001372
111 ACTIN FILAMENT BASED MOVEMENT 18 93 3.594e-06 0.0001492
112 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 125 1492 3.612e-06 0.0001492
113 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 116 1360 3.623e-06 0.0001492
114 NEGATIVE REGULATION OF GENE EXPRESSION 125 1493 3.734e-06 0.0001524
115 REGULATION OF CELLULAR COMPONENT BIOGENESIS 74 767 3.798e-06 0.0001537
116 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 46 404 4.305e-06 0.0001727
117 MULTICELLULAR ORGANISMAL SIGNALING 21 123 4.714e-06 0.0001875
118 PEPTIDYL AMINO ACID MODIFICATION 79 841 4.875e-06 0.0001922
119 FOREBRAIN DEVELOPMENT 42 357 4.932e-06 0.0001929
120 POSITIVE REGULATION OF KINASE ACTIVITY 52 482 5.079e-06 0.0001969
121 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 76 801 5.163e-06 0.0001985
122 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 51 470 5.305e-06 0.0002023
123 GLAND DEVELOPMENT 45 395 5.379e-06 0.0002035
124 REGULATION OF NEURON PROJECTION DEVELOPMENT 46 408 5.598e-06 0.00021
125 RENAL TUBULE DEVELOPMENT 16 78 5.647e-06 0.0002102
126 REGULATION OF KINASE ACTIVITY 74 776 5.757e-06 0.0002126
127 NEPHRON DEVELOPMENT 20 115 5.907e-06 0.0002164
128 STEROID HORMONE MEDIATED SIGNALING PATHWAY 21 125 6.128e-06 0.0002228
129 NEURAL PRECURSOR CELL PROLIFERATION 15 70 6.259e-06 0.0002258
130 REGULATION OF PEPTIDE SECRETION 29 209 6.32e-06 0.0002262
131 GROWTH 46 410 6.371e-06 0.0002263
132 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 57 554 7.708e-06 0.0002717
133 HORMONE MEDIATED SIGNALING PATHWAY 24 158 8.329e-06 0.0002914
134 LIPID PHOSPHORYLATION 18 99 9.016e-06 0.0003131
135 SKELETAL SYSTEM DEVELOPMENT 49 455 9.918e-06 0.0003419
136 METANEPHRIC NEPHRON MORPHOGENESIS 8 21 1.023e-05 0.0003475
137 PLASMA MEMBRANE ORGANIZATION 28 203 1.017e-05 0.0003475
138 EMBRYONIC ORGAN DEVELOPMENT 45 406 1.095e-05 0.0003692
139 CELLULAR RESPONSE TO LIPID 49 457 1.116e-05 0.0003737
140 POSITIVE REGULATION OF MAPK CASCADE 50 470 1.128e-05 0.000375
141 NEGATIVE REGULATION OF TRANSPORT 49 458 1.184e-05 0.0003879
142 DEVELOPMENTAL GROWTH 39 333 1.182e-05 0.0003879
143 RESPONSE TO OXYGEN CONTAINING COMPOUND 115 1381 1.203e-05 0.0003914
144 REGULATION OF HORMONE SECRETION 33 262 1.227e-05 0.0003964
145 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 7 16 1.27e-05 0.0004074
146 RHYTHMIC PROCESS 36 298 1.284e-05 0.0004094
147 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 21 131 1.297e-05 0.0004105
148 MUSCLE TISSUE DEVELOPMENT 34 275 1.357e-05 0.0004267
149 REGULATION OF PROTEIN LOCALIZATION 85 950 1.379e-05 0.0004307
150 REGULATION OF ION TRANSPORT 59 592 1.409e-05 0.000437
151 POSITIVE REGULATION OF LIPASE ACTIVITY 14 66 1.435e-05 0.0004422
152 NEPHRON EPITHELIUM DEVELOPMENT 17 93 1.476e-05 0.0004517
153 CELL JUNCTION ORGANIZATION 26 185 1.489e-05 0.000453
154 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 18 103 1.591e-05 0.0004808
155 RESPIRATORY SYSTEM DEVELOPMENT 27 197 1.636e-05 0.000491
156 NEGATIVE REGULATION OF CELL DIFFERENTIATION 60 609 1.687e-05 0.0005033
157 VASCULOGENESIS 13 59 1.874e-05 0.0005555
158 RESPONSE TO ORGANIC CYCLIC COMPOUND 82 917 2.001e-05 0.0005894
159 ODONTOGENESIS 18 105 2.088e-05 0.0006112
160 ANGIOGENESIS 35 293 2.146e-05 0.0006241
161 REGULATION OF OSSIFICATION 25 178 2.183e-05 0.0006309
162 POSITIVE REGULATION OF NEURON DIFFERENTIATION 36 306 2.294e-05 0.0006558
163 REGULATION OF CELL CYCLE 84 949 2.297e-05 0.0006558
164 REGULATION OF CELL ADHESION 61 629 2.312e-05 0.0006559
165 REGULATION OF CELL MORPHOGENESIS 55 552 2.755e-05 0.0007768
166 REGULATION OF EPITHELIAL CELL PROLIFERATION 34 285 2.875e-05 0.0008037
167 NEGATIVE REGULATION OF PHOSPHORYLATION 45 422 2.884e-05 0.0008037
168 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 21 138 2.914e-05 0.000807
169 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 122 1517 3.194e-05 0.0008794
170 RESPONSE TO OXYGEN LEVELS 36 311 3.25e-05 0.0008895
171 COGNITION 31 251 3.273e-05 0.0008906
172 CONNECTIVE TISSUE DEVELOPMENT 26 194 3.451e-05 0.0009336
173 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 48 465 3.648e-05 0.0009756
174 ENDOMEMBRANE SYSTEM ORGANIZATION 48 465 3.648e-05 0.0009756
175 MESONEPHROS DEVELOPMENT 16 90 3.736e-05 0.0009934
176 CELLULAR RESPONSE TO NITROGEN COMPOUND 51 505 3.762e-05 0.0009945
177 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 28 218 3.837e-05 0.001009
178 REGULATION OF CELL SUBSTRATE ADHESION 24 173 3.88e-05 0.001014
179 WNT SIGNALING PATHWAY 39 351 3.922e-05 0.00102
180 NEURON PROJECTION MORPHOGENESIS 43 402 4.006e-05 0.00103
181 NEURON MIGRATION 18 110 3.985e-05 0.00103
182 REGULATION OF ORGAN MORPHOGENESIS 30 242 4.062e-05 0.001039
183 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 39 352 4.178e-05 0.001062
184 EPITHELIAL CELL DEVELOPMENT 25 186 4.617e-05 0.001167
185 METANEPHRIC NEPHRON DEVELOPMENT 9 32 4.688e-05 0.001179
186 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 85 983 4.75e-05 0.001182
187 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 14 73 4.746e-05 0.001182
188 REGULATION OF PEPTIDE TRANSPORT 31 256 4.79e-05 0.001185
189 POSITIVE REGULATION OF RESPONSE TO STIMULUS 148 1929 4.83e-05 0.001189
190 REGULATION OF CELLULAR LOCALIZATION 105 1277 4.911e-05 0.001203
191 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 19 122 4.977e-05 0.001212
192 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 40 368 5.151e-05 0.001248
193 CELL PART MORPHOGENESIS 60 633 5.216e-05 0.001256
194 REGULATION OF DENDRITIC SPINE DEVELOPMENT 12 56 5.237e-05 0.001256
195 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 20 133 5.32e-05 0.001263
196 REGULATION OF LIPASE ACTIVITY 15 83 5.319e-05 0.001263
197 POSITIVE REGULATION OF LOCOMOTION 44 420 5.376e-05 0.00127
198 REGULATION OF MAP KINASE ACTIVITY 36 319 5.554e-05 0.001305
199 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 6 14 6.317e-05 0.001477
200 TAXIS 47 464 6.967e-05 0.001621
201 CELLULAR RESPONSE TO ALCOHOL 18 115 7.279e-05 0.001685
202 CELLULAR RESPONSE TO PEPTIDE 32 274 7.366e-05 0.001697
203 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 58 616 8.315e-05 0.001906
204 LIPID LOCALIZATION 31 264 8.57e-05 0.001945
205 TELENCEPHALON DEVELOPMENT 28 228 8.54e-05 0.001945
206 EYE DEVELOPMENT 36 326 8.693e-05 0.001964
207 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 28 229 9.22e-05 0.002072
208 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 18 118 0.0001025 0.002293
209 EMBRYONIC ORGAN MORPHOGENESIS 32 279 0.0001039 0.002313
210 PROTEIN LOCALIZATION 138 1805 0.0001048 0.002322
211 EXTRACELLULAR STRUCTURE ORGANIZATION 34 304 0.0001054 0.002325
212 REGULATION OF STEM CELL PROLIFERATION 15 88 0.0001067 0.002341
213 REGULATION OF NEUROBLAST PROLIFERATION 8 28 0.0001099 0.0024
214 DENDRITE DEVELOPMENT 14 79 0.0001166 0.002536
215 EPITHELIAL CELL PROLIFERATION 15 89 0.0001217 0.002622
216 POST EMBRYONIC DEVELOPMENT 15 89 0.0001217 0.002622
217 LIPID METABOLIC PROCESS 95 1158 0.000123 0.002627
218 REGULATION OF CYTOSKELETON ORGANIZATION 49 502 0.0001231 0.002627
219 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 9 36 0.0001284 0.002728
220 LIPID MODIFICATION 26 210 0.0001318 0.002776
221 REGULATION OF BLOOD CIRCULATION 33 295 0.0001319 0.002776
222 REGULATION OF BINDING 32 283 0.0001356 0.002843
223 REGULATION OF CELL MATRIX ADHESION 15 90 0.0001386 0.002892
224 REGULATION OF HORMONE LEVELS 47 478 0.0001416 0.002941
225 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 11 53 0.0001448 0.002956
226 MAMMARY GLAND EPITHELIUM DEVELOPMENT 11 53 0.0001448 0.002956
227 CARDIAC MUSCLE CELL CONTRACTION 8 29 0.0001443 0.002956
228 REGULATION OF SYNAPTIC TRANSMISSION GABAERGIC 8 29 0.0001443 0.002956
229 CELL CYCLE ARREST 21 154 0.0001479 0.002994
230 SECRETION 55 588 0.0001493 0.002994
231 RAS PROTEIN SIGNAL TRANSDUCTION 20 143 0.0001487 0.002994
232 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 12 62 0.0001484 0.002994
233 MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION 6 16 0.0001528 0.003039
234 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 6 16 0.0001528 0.003039
235 NEGATIVE REGULATION OF CELL DEATH 75 872 0.0001559 0.003087
236 REGULATION OF TRANSFERASE ACTIVITY 80 946 0.0001636 0.0032
237 RESPONSE TO ALCOHOL 38 362 0.0001625 0.0032
238 SKELETAL SYSTEM MORPHOGENESIS 25 201 0.0001637 0.0032
239 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 30 262 0.0001736 0.003335
240 REGULATION OF ACTIN FILAMENT BASED PROCESS 34 312 0.0001742 0.003335
241 MESENCHYME DEVELOPMENT 24 190 0.000173 0.003335
242 STEM CELL DIFFERENTIATION 24 190 0.000173 0.003335
243 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 24 190 0.000173 0.003335
244 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 8 30 0.0001871 0.003569
245 ADRENAL GLAND DEVELOPMENT 7 23 0.0001922 0.003651
246 REGULATION OF DEVELOPMENTAL GROWTH 32 289 0.0001997 0.003777
247 COLLAGEN FIBRIL ORGANIZATION 9 38 0.0002009 0.003785
248 REGULATION OF DNA BINDING 15 93 0.000202 0.003789
249 CIRCULATORY SYSTEM PROCESS 38 366 0.0002032 0.003798
250 REGULATION OF KIDNEY DEVELOPMENT 11 55 0.0002051 0.003818
251 MUSCLE ORGAN DEVELOPMENT 31 277 0.0002063 0.003824
252 CARTILAGE DEVELOPMENT 20 147 0.0002172 0.004011
253 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 64 724 0.0002229 0.004057
254 REGULATION OF HOMEOSTATIC PROCESS 44 447 0.0002226 0.004057
255 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 6 17 0.000225 0.004057
256 ACTIN MEDIATED CELL CONTRACTION 13 74 0.0002216 0.004057
257 MAMMARY GLAND ALVEOLUS DEVELOPMENT 6 17 0.000225 0.004057
258 MAMMARY GLAND LOBULE DEVELOPMENT 6 17 0.000225 0.004057
259 ACTION POTENTIAL 15 94 0.000228 0.004096
260 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 65 740 0.0002381 0.004261
261 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 126 0.0002394 0.004267
262 POSITIVE REGULATION OF AUTOPHAGY 13 75 0.0002545 0.00452
263 EAR DEVELOPMENT 24 195 0.0002572 0.00455
264 NEURAL TUBE DEVELOPMENT 20 149 0.0002608 0.004597
265 MAMMARY GLAND DEVELOPMENT 17 117 0.0002875 0.005047
266 POSITIVE REGULATION OF TRANSPORTER ACTIVITY 13 76 0.0002915 0.005099
267 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 74 876 0.0002953 0.005141
268 REGULATION OF TRANSMEMBRANE TRANSPORT 42 426 0.0002961 0.005141
269 RESPONSE TO WOUNDING 52 563 0.0003037 0.005237
270 NEGATIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 9 40 0.0003045 0.005237
271 REGULATION OF GROWTH 57 633 0.000305 0.005237
272 PROTEIN LOCALIZATION TO CELL PERIPHERY 20 151 0.000312 0.005336
273 CARDIAC MUSCLE TISSUE DEVELOPMENT 19 140 0.0003192 0.00544
274 SMOOTH MUSCLE TISSUE DEVELOPMENT 6 18 0.0003215 0.005459
275 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 10 49 0.0003332 0.005638
276 CELLULAR RESPONSE TO ACID CHEMICAL 22 175 0.000339 0.005715
277 EPITHELIAL TUBE BRANCHING INVOLVED IN LUNG MORPHOGENESIS 7 25 0.0003414 0.005715
278 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 25 0.0003414 0.005715
279 REGIONALIZATION 33 311 0.0003508 0.005851
280 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 337 0.0003538 0.005879
281 ORGAN GROWTH 12 68 0.0003667 0.006073
282 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 20 153 0.0003716 0.006131
283 IMMUNE SYSTEM DEVELOPMENT 53 582 0.0003752 0.006169
284 EMBRYONIC EYE MORPHOGENESIS 8 33 0.000382 0.006258
285 PATTERN SPECIFICATION PROCESS 41 418 0.0003862 0.006305
286 MUSCLE CELL DIFFERENTIATION 27 237 0.0003887 0.006323
287 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 92 1152 0.0003914 0.006345
288 REGULATION OF ADHERENS JUNCTION ORGANIZATION 10 50 0.0003958 0.006394
289 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 20 154 0.000405 0.006498
290 RESPONSE TO STARVATION 20 154 0.000405 0.006498
291 NEGATIVE REGULATION OF CELL CYCLE 42 433 0.000416 0.006651
292 REGULATION OF SECRETION 61 699 0.0004338 0.006889
293 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 31 289 0.0004338 0.006889
294 RESPONSE TO NITROGEN COMPOUND 72 859 0.0004437 0.007002
295 SENSORY ORGAN MORPHOGENESIS 27 239 0.000444 0.007002
296 REGULATION OF ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLE PROPIONATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 6 19 0.0004476 0.007008
297 NEGATIVE REGULATION OF GTPASE ACTIVITY 9 42 0.0004488 0.007008
298 LENS MORPHOGENESIS IN CAMERA TYPE EYE 6 19 0.0004476 0.007008
299 REGULATION OF GLUCOSE IMPORT 11 60 0.0004543 0.00707
300 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 24 203 0.0004677 0.007254
301 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 34 0.0004752 0.007321
302 ADHERENS JUNCTION ASSEMBLY 8 34 0.0004752 0.007321
303 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 42 437 0.0005025 0.007716
304 REGULATION OF OSTEOBLAST DIFFERENTIATION 16 112 0.00052 0.007958
305 APPENDAGE DEVELOPMENT 21 169 0.0005352 0.008138
306 LIMB DEVELOPMENT 21 169 0.0005352 0.008138
307 NEURON PROJECTION GUIDANCE 24 205 0.0005395 0.008177
308 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 23 193 0.0005434 0.008209
309 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 12 71 0.0005522 0.008316
310 POSITIVE REGULATION OF HEART GROWTH 7 27 0.0005715 0.008551
311 DEVELOPMENTAL INDUCTION 7 27 0.0005715 0.008551
312 REGULATION OF LIPID METABOLIC PROCESS 30 282 0.0006106 0.009049
313 INTRACELLULAR LIPID TRANSPORT 6 20 0.0006092 0.009049
314 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 6 20 0.0006092 0.009049
315 CELL CELL SIGNALING 65 767 0.0006236 0.009148
316 REGULATION OF CIRCADIAN RHYTHM 15 103 0.0006252 0.009148
317 POSITIVE REGULATION OF MAP KINASE ACTIVITY 24 207 0.0006208 0.009148
318 CARDIAC CONDUCTION 13 82 0.0006235 0.009148
319 RESPONSE TO STEROID HORMONE 46 497 0.000632 0.009167
320 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 26 232 0.0006338 0.009167
321 REGULATION OF ENDOTHELIAL CELL MIGRATION 16 114 0.0006344 0.009167
322 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 26 232 0.0006338 0.009167
323 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 9 44 0.0006451 0.009264
324 MESONEPHRIC TUBULE MORPHOGENESIS 10 53 0.0006448 0.009264
325 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 15 104 0.0006934 0.009927
326 REGULATION OF HEART CONTRACTION 25 221 0.0006962 0.009936
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 88 640 4.818e-15 4.476e-12
2 KINASE ACTIVITY 103 842 5.131e-14 2.384e-11
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 105 992 2.125e-10 6.579e-08
4 ADENYL NUCLEOTIDE BINDING 143 1514 3.433e-10 7.973e-08
5 MOLECULAR FUNCTION REGULATOR 128 1353 2.956e-09 5.492e-07
6 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 37 228 5.469e-09 8.467e-07
7 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 115 1199 9.514e-09 1.263e-06
8 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 20 81 1.474e-08 1.522e-06
9 PROTEIN TYROSINE KINASE ACTIVITY 31 176 1.318e-08 1.522e-06
10 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 43 303 2.067e-08 1.904e-06
11 RIBONUCLEOTIDE BINDING 160 1860 2.254e-08 1.904e-06
12 PROTEIN SERINE THREONINE KINASE ACTIVITY 55 445 3.334e-08 2.581e-06
13 ZINC ION BINDING 109 1155 5.593e-08 3.997e-06
14 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 16 64 3.372e-07 2.088e-05
15 GROWTH FACTOR BINDING 23 123 3.193e-07 2.088e-05
16 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 66 629 7.493e-07 4.351e-05
17 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 16 70 1.245e-06 6.801e-05
18 ENZYME BINDING 142 1737 2.821e-06 0.0001456
19 TRANSITION METAL ION BINDING 119 1400 3.171e-06 0.0001551
20 CYTOSKELETAL PROTEIN BINDING 77 819 6.238e-06 0.0002898
21 MACROMOLECULAR COMPLEX BINDING 117 1399 8.252e-06 0.000365
22 ACTIN BINDING 44 393 1.062e-05 0.0004483
23 KINASE BINDING 60 606 1.455e-05 0.0005877
24 CELL ADHESION MOLECULE BINDING 26 186 1.641e-05 0.0006351
25 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 38 328 1.947e-05 0.0007234
26 INTEGRIN BINDING 18 105 2.088e-05 0.0007462
27 PROTEIN COMPLEX BINDING 83 935 2.319e-05 0.0007692
28 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 58 588 2.246e-05 0.0007692
29 PROTEIN DOMAIN SPECIFIC BINDING 60 624 3.456e-05 0.001107
30 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 20 133 5.32e-05 0.001647
31 STEROID HORMONE RECEPTOR ACTIVITY 12 59 8.985e-05 0.002693
32 ION CHANNEL BINDING 17 111 0.0001504 0.004366
33 PHOSPHATIDYLINOSITOL 3 KINASE BINDING 8 30 0.0001871 0.005268
34 TRANSCRIPTION COACTIVATOR BINDING 5 11 0.000193 0.005275
35 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 34 315 0.0002089 0.005544
36 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 10 48 0.0002791 0.007067
37 REGULATORY REGION NUCLEIC ACID BINDING 70 818 0.0002967 0.007067
38 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 13 76 0.0002915 0.007067
39 RECEPTOR BINDING 114 1476 0.0002951 0.007067
40 DOUBLE STRANDED DNA BINDING 66 764 0.0003389 0.007872
41 PHOSPHATIDYLINOSITOL BINDING 24 200 0.0003756 0.008511
42 LIPID BINDING 58 657 0.0004473 0.009893
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 102 942 1.093e-10 6.384e-08
2 SYNAPSE 85 754 6.134e-10 1.791e-07
3 NEURON PART 123 1265 1.203e-09 1.945e-07
4 CELL PROJECTION 160 1786 1.332e-09 1.945e-07
5 CELL JUNCTION 112 1151 6.836e-09 7.984e-07
6 POSTSYNAPSE 49 378 4.216e-08 4.104e-06
7 SYNAPSE PART 68 610 5.216e-08 4.352e-06
8 CELL PROJECTION PART 93 946 8.845e-08 6.457e-06
9 SOMATODENDRITIC COMPARTMENT 70 650 1.283e-07 8.326e-06
10 APICAL JUNCTION COMPLEX 24 128 1.687e-07 9.853e-06
11 EXCITATORY SYNAPSE 31 197 1.906e-07 1.012e-05
12 GOLGI APPARATUS 127 1445 2.426e-07 1.18e-05
13 MEMBRANE REGION 103 1134 8.239e-07 3.701e-05
14 CELL CELL JUNCTION 45 383 2.369e-06 9.881e-05
15 PLASMA MEMBRANE REGION 85 929 5.921e-06 0.0002305
16 CELL CORTEX 31 238 1.138e-05 0.0004154
17 CYTOPLASMIC REGION 35 287 1.375e-05 0.0004724
18 MEMBRANE MICRODOMAIN 34 288 3.568e-05 0.001158
19 PROTEINACEOUS EXTRACELLULAR MATRIX 39 356 5.36e-05 0.001648
20 FILOPODIUM 16 94 6.467e-05 0.001888
21 INTRACELLULAR VESICLE 103 1259 7.068e-05 0.001966
22 CELL LEADING EDGE 38 350 8.048e-05 0.002065
23 PLASMA MEMBRANE RAFT 15 86 8.134e-05 0.002065
24 INTRINSIC COMPONENT OF PLASMA MEMBRANE 128 1649 9.952e-05 0.002325
25 AXON 43 418 9.867e-05 0.002325
26 VESICLE MEMBRANE 50 512 0.0001041 0.002339
27 ACTOMYOSIN 12 62 0.0001484 0.002989
28 CYTOPLASMIC VESICLE PART 56 601 0.0001441 0.002989
29 DENDRITE 45 451 0.0001395 0.002989
30 CELL BODY 48 494 0.0001601 0.003117
31 CELL CELL CONTACT ZONE 12 64 0.0002034 0.003832
32 CYTOSKELETON 146 1967 0.0002553 0.004424
33 CELL SURFACE 66 757 0.000263 0.004424
34 LAMELLIPODIUM 22 172 0.0002652 0.004424
35 AXON PART 26 219 0.0002595 0.004424
36 ACTIN FILAMENT BUNDLE 11 57 0.0002854 0.004629
37 EXTRACELLULAR MATRIX 42 426 0.0002961 0.004673
38 GOLGI APPARATUS PART 75 893 0.0003198 0.004915
39 RECYCLING ENDOSOME 18 131 0.0003896 0.005834
40 RECEPTOR COMPLEX 34 327 0.0004179 0.006101
41 NEURON SPINE 17 121 0.0004301 0.006127
42 ANCHORING JUNCTION 46 489 0.000446 0.006201
43 ACTIN BASED CELL PROJECTION 22 181 0.0005422 0.007364

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04144_Endocytosis 30 203 1.175e-06 0.0001126
2 hsa04014_Ras_signaling_pathway 33 236 1.251e-06 0.0001126
3 hsa04510_Focal_adhesion 29 200 2.605e-06 0.0001563
4 hsa04151_PI3K_AKT_signaling_pathway 41 351 7.593e-06 0.0002804
5 hsa04010_MAPK_signaling_pathway 34 268 7.788e-06 0.0002804
6 hsa04514_Cell_adhesion_molecules_.CAMs. 20 136 7.335e-05 0.002101
7 hsa04270_Vascular_smooth_muscle_contraction 18 116 8.171e-05 0.002101
8 hsa04720_Long.term_potentiation 13 70 0.0001238 0.002785
9 hsa04810_Regulation_of_actin_cytoskeleton 26 214 0.0001793 0.00346
10 hsa04710_Circadian_rhythm_._mammal 7 23 0.0001922 0.00346
11 hsa04390_Hippo_signaling_pathway 20 154 0.000405 0.006627
12 hsa04310_Wnt_signaling_pathway 19 151 0.0008273 0.01224
13 hsa04512_ECM.receptor_interaction 13 85 0.0008839 0.01224
14 hsa04350_TGF.beta_signaling_pathway 12 85 0.002762 0.03551
15 hsa04530_Tight_junction 16 133 0.003261 0.03913
16 hsa04912_GnRH_signaling_pathway 13 101 0.004276 0.04528
17 hsa04916_Melanogenesis 13 101 0.004276 0.04528
18 hsa04910_Insulin_signaling_pathway 16 138 0.0047 0.047
19 hsa04360_Axon_guidance 15 130 0.006354 0.0574
20 hsa04630_Jak.STAT_signaling_pathway 17 155 0.006377 0.0574
21 hsa04971_Gastric_acid_secretion 10 74 0.008215 0.07041
22 hsa02010_ABC_transporters 7 44 0.01075 0.08794
23 hsa04540_Gap_junction 11 90 0.01198 0.09374
24 hsa04340_Hedgehog_signaling_pathway 8 56 0.01251 0.09379
25 hsa04920_Adipocytokine_signaling_pathway 9 68 0.0135 0.0972
26 hsa04730_Long.term_depression 9 70 0.01614 0.1117
27 hsa04666_Fc_gamma_R.mediated_phagocytosis 11 95 0.01748 0.1165
28 hsa04150_mTOR_signaling_pathway 7 52 0.02552 0.1641
29 hsa04114_Oocyte_meiosis 12 114 0.02654 0.1648
30 hsa04070_Phosphatidylinositol_signaling_system 9 78 0.03051 0.183
31 hsa04062_Chemokine_signaling_pathway 17 189 0.03782 0.2196
32 hsa00562_Inositol_phosphate_metabolism 7 57 0.03972 0.2234
33 hsa04520_Adherens_junction 8 73 0.05181 0.2767
34 hsa04012_ErbB_signaling_pathway 9 87 0.05527 0.2767
35 hsa04914_Progesterone.mediated_oocyte_maturation 9 87 0.05527 0.2767
36 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 4 26 0.05534 0.2767
37 hsa00010_Glycolysis_._Gluconeogenesis 7 65 0.07159 0.3481
38 hsa04020_Calcium_signaling_pathway 15 177 0.0739 0.3481
39 hsa04664_Fc_epsilon_RI_signaling_pathway 8 79 0.07541 0.3481
40 hsa00531_Glycosaminoglycan_degradation 3 19 0.08767 0.3945
41 hsa04722_Neurotrophin_signaling_pathway 11 127 0.1016 0.4397
42 hsa00640_Propanoate_metabolism 4 32 0.1026 0.4397
43 hsa04972_Pancreatic_secretion 9 101 0.1144 0.4791
44 hsa04140_Regulation_of_autophagy 4 34 0.1214 0.4968
45 hsa04320_Dorso.ventral_axis_formation 3 25 0.1633 0.639
46 hsa00500_Starch_and_sucrose_metabolism 5 54 0.1855 0.7045
47 hsa04115_p53_signaling_pathway 6 69 0.1907 0.7045
48 hsa00052_Galactose_metabolism 3 27 0.1918 0.7045
49 hsa03320_PPAR_signaling_pathway 6 70 0.1995 0.7182
50 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 0.2089 0.7333
51 hsa04670_Leukocyte_transendothelial_migration 9 117 0.2119 0.7333
52 hsa00071_Fatty_acid_metabolism 4 43 0.2209 0.734
53 hsa04962_Vasopressin.regulated_water_reabsorption 4 44 0.2331 0.734
54 hsa04210_Apoptosis 7 89 0.2334 0.734
55 hsa04970_Salivary_secretion 7 89 0.2334 0.734
56 hsa04650_Natural_killer_cell_mediated_cytotoxicity 10 136 0.2349 0.734
57 hsa00512_Mucin_type_O.Glycan_biosynthesis 3 30 0.2365 0.734
58 hsa04370_VEGF_signaling_pathway 6 76 0.2547 0.7771
59 hsa04660_T_cell_receptor_signaling_pathway 8 108 0.2614 0.7843
60 hsa00250_Alanine._aspartate_and_glutamate_metabolism 3 32 0.2672 0.7885
61 hsa00564_Glycerophospholipid_metabolism 6 80 0.2936 0.8524
62 hsa04974_Protein_digestion_and_absorption 6 81 0.3035 0.8672
63 hsa00561_Glycerolipid_metabolism 4 50 0.3089 0.8688
64 hsa00410_beta.Alanine_metabolism 2 22 0.3529 0.9773
65 hsa00600_Sphingolipid_metabolism 3 40 0.3921 1
66 hsa00620_Pyruvate_metabolism 3 40 0.3921 1
67 hsa04662_B_cell_receptor_signaling_pathway 5 75 0.4143 1
68 hsa04260_Cardiac_muscle_contraction 5 77 0.4368 1
69 hsa04146_Peroxisome 5 79 0.459 1
70 hsa04141_Protein_processing_in_endoplasmic_reticulum 10 168 0.4724 1
71 hsa04330_Notch_signaling_pathway 3 47 0.4967 1
72 hsa00650_Butanoate_metabolism 2 30 0.5087 1
73 hsa00510_N.Glycan_biosynthesis 3 49 0.5249 1
74 hsa04672_Intestinal_immune_network_for_IgA_production 3 49 0.5249 1
75 hsa00260_Glycine._serine_and_threonine_metabolism 2 32 0.5437 1
76 hsa04610_Complement_and_coagulation_cascades 4 69 0.5477 1
77 hsa04640_Hematopoietic_cell_lineage 5 88 0.5551 1
78 hsa03018_RNA_degradation 4 71 0.5706 1
79 hsa04976_Bile_secretion 4 71 0.5706 1
80 hsa00330_Arginine_and_proline_metabolism 3 54 0.5915 1
81 hsa00565_Ether_lipid_metabolism 2 36 0.6084 1
82 hsa04130_SNARE_interactions_in_vesicular_transport 2 36 0.6084 1
83 hsa03022_Basal_transcription_factors 2 37 0.6234 1
84 hsa04612_Antigen_processing_and_presentation 4 78 0.6452 1
85 hsa04145_Phagosome 8 156 0.6553 1
86 hsa00380_Tryptophan_metabolism 2 42 0.6919 1
87 hsa03015_mRNA_surveillance_pathway 4 83 0.6929 1
88 hsa00280_Valine._leucine_and_isoleucine_degradation 2 44 0.7163 1
89 hsa00310_Lysine_degradation 2 44 0.7163 1
90 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.7163 1
91 hsa04110_Cell_cycle 6 128 0.7318 1
92 hsa04380_Osteoclast_differentiation 6 128 0.7318 1
93 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 2 48 0.7601 1
94 hsa04742_Taste_transduction 2 52 0.798 1
95 hsa04120_Ubiquitin_mediated_proteolysis 6 139 0.7998 1
96 hsa00140_Steroid_hormone_biosynthesis 2 57 0.8378 1
97 hsa04142_Lysosome 4 121 0.9141 1
98 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 2 71 0.9143 1
99 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.9143 1
100 hsa00240_Pyrimidine_metabolism 3 99 0.922 1
101 hsa00230_Purine_metabolism 5 162 0.9536 1
102 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.9808 1
103 hsa03013_RNA_transport 3 152 0.9924 1
104 hsa04740_Olfactory_transduction 4 388 1 1

Quest ID: a49749069bdf4445b769be1b6fbe878a