Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-92b-3p ADAM22 0.29 0.00599 -2.81 0 mirMAP -0.46 2.0E-5 NA
2 hsa-miR-92b-3p ADCY1 0.29 0.00599 -0.58 0.00043 mirMAP -0.51 0 NA
3 hsa-miR-92b-3p ADCY3 0.29 0.00599 0.21 0.00761 miRNATAP -0.16 0 NA
4 hsa-miR-92b-3p ADCY9 0.29 0.00599 -0.41 0 mirMAP -0.22 0 NA
5 hsa-miR-92b-3p AKAP12 0.29 0.00599 -1.42 0 mirMAP -0.31 0 NA
6 hsa-miR-92b-3p ALDH1L2 0.29 0.00599 -1.01 0 mirMAP -0.17 0.02375 NA
7 hsa-miR-92b-3p ALDH7A1 0.29 0.00599 -0.65 0 mirMAP -0.13 3.0E-5 NA
8 hsa-miR-92b-3p ALDOA 0.29 0.00599 0.17 0.00869 miRNAWalker2 validate -0.11 3.0E-5 NA
9 hsa-miR-92b-3p ALPK3 0.29 0.00599 0.02 0.84026 mirMAP; miRNATAP -0.17 5.0E-5 NA
10 hsa-miR-92b-3p ANK3 0.29 0.00599 -0.98 0 MirTarget -0.24 0 NA
11 hsa-miR-92b-3p AP3S2 0.29 0.00599 -0.02 0.72565 mirMAP -0.15 0 NA
12 hsa-miR-92b-3p APOLD1 0.29 0.00599 -0.06 0.73919 miRNAWalker2 validate -0.4 0 NA
13 hsa-miR-92b-3p ARHGAP24 0.29 0.00599 -2.23 0 MirTarget -0.8 0 NA
14 hsa-miR-92b-3p ARRDC4 0.29 0.00599 -0.53 0 MirTarget; miRNATAP -0.19 1.0E-5 NA
15 hsa-miR-92b-3p ATP5G3 0.29 0.00599 -0.07 0.32929 miRNAWalker2 validate -0.12 1.0E-5 NA
16 hsa-miR-92b-3p ATP8B1 0.29 0.00599 -0.25 0.00287 miRNATAP -0.11 0.00165 NA
17 hsa-let-7b-5p AURKA -0.75 0 -0.28 0.00642 miRNAWalker2 validate -0.12 0.00522 NA
18 hsa-miR-30c-2-3p AURKA -0.79 0 -0.28 0.00642 MirTarget -0.14 8.0E-5 NA
19 hsa-miR-92b-3p B3GALT2 0.29 0.00599 -3.21 0 MirTarget; miRNATAP -0.24 0.03514 NA
20 hsa-miR-92b-3p BCAT2 0.29 0.00599 -0.16 0.03619 miRNATAP -0.19 0 NA
21 hsa-miR-92b-3p BCKDHB 0.29 0.00599 -0.44 0 mirMAP -0.13 0 NA
22 hsa-miR-92b-3p BCL11A 0.29 0.00599 -1.23 0 MirTarget -0.3 1.0E-5 NA
23 hsa-miR-92b-3p BCL11B 0.29 0.00599 -1.63 0 MirTarget -0.27 0.00051 NA
24 hsa-miR-92b-3p BMP8B 0.29 0.00599 -1.2 0 mirMAP -0.49 0 NA
25 hsa-miR-92b-3p C2CD2 0.29 0.00599 -0.22 0.00029 mirMAP -0.22 0 NA
26 hsa-miR-92b-3p C5orf30 0.29 0.00599 -0.52 0 miRNATAP -0.27 0 NA
27 hsa-miR-92b-3p CACNA1H 0.29 0.00599 -1.09 0 miRNATAP -0.46 0 NA
28 hsa-miR-92b-3p CACNA1I 0.29 0.00599 -1.11 0 MirTarget; miRNATAP -0.41 2.0E-5 NA
29 hsa-miR-92b-3p CACNB4 0.29 0.00599 -1.22 0 mirMAP -0.5 0 NA
30 hsa-miR-92b-3p CALCOCO2 0.29 0.00599 -0.53 0 mirMAP -0.14 0 NA
31 hsa-miR-92b-3p CAMK1D 0.29 0.00599 -1.32 0 mirMAP -0.21 2.0E-5 NA
32 hsa-miR-92b-3p CASKIN1 0.29 0.00599 0.48 0.00354 mirMAP -0.15 0.02162 NA
33 hsa-miR-92b-3p CBFA2T3 0.29 0.00599 -0.33 0.02093 MirTarget; miRNATAP -0.33 0 NA
34 hsa-let-7b-3p CCNA2 -0.84 0 0.48 0.00052 MirTarget -0.21 0.00181 NA
35 hsa-miR-130a-3p CCNA2 -0.74 0 0.48 0.00052 miRNATAP -0.11 0.03288 NA
36 hsa-miR-22-3p CCNA2 -0.1 0.18413 0.48 0.00052 MirTarget -0.21 0.00888 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers
37 hsa-miR-27b-3p CCNA2 0.27 0.00111 0.48 0.00052 miRNATAP -0.22 0.00144 NA
38 hsa-miR-374b-5p CCNA2 -0.76 0 0.48 0.00052 mirMAP -0.27 0.00051 NA
39 hsa-miR-486-5p CCNA2 -2.71 0 0.48 0.00052 miRanda -0.11 4.0E-5 NA
40 hsa-miR-98-5p CCNA2 -0.33 3.0E-5 0.48 0.00052 miRNAWalker2 validate -0.62 0 NA
41 hsa-miR-92b-3p CDCA7L 0.29 0.00599 -0.38 0.00068 MirTarget; miRNATAP -0.17 0.00027 NA
42 hsa-miR-92b-3p CDK6 0.29 0.00599 -0.48 4.0E-5 miRNATAP -0.39 0 NA
43 hsa-miR-92b-3p CEBPA 0.29 0.00599 -0.37 0.01752 miRNATAP -0.47 0 NA
44 hsa-miR-92b-3p CEBPG 0.29 0.00599 -0.19 0.04624 mirMAP -0.13 0.00069 NA
45 hsa-miR-92b-3p CHCHD10 0.29 0.00599 -0.84 0 MirTarget -0.42 0 NA
46 hsa-miR-92b-3p CHKA 0.29 0.00599 -0.5 0 MirTarget -0.25 0 NA
47 hsa-miR-92b-3p CHST7 0.29 0.00599 0.74 0 MirTarget -0.15 0.00511 NA
48 hsa-miR-92b-3p CPEB3 0.29 0.00599 -0.89 0 MirTarget; miRNATAP -0.21 0 NA
49 hsa-miR-92b-3p CPEB4 0.29 0.00599 -0.83 0 miRNATAP -0.12 0.00383 NA
50 hsa-miR-92b-3p CPT1A 0.29 0.00599 -0.42 0 mirMAP -0.27 0 NA
51 hsa-miR-92b-3p CSMD1 0.29 0.00599 1.64 0 miRNATAP -0.36 0.01178 NA
52 hsa-miR-92b-3p DCLK2 0.29 0.00599 -0.4 0.00156 miRNATAP -0.46 0 NA
53 hsa-miR-92b-3p DIO2 0.29 0.00599 -1.99 0 mirMAP -0.65 0 NA
54 hsa-miR-92b-3p DKK3 0.29 0.00599 0.19 0.07948 MirTarget -0.15 0.00039 NA
55 hsa-miR-92b-3p DLG2 0.29 0.00599 -3.48 0 mirMAP -0.87 0 NA
56 hsa-miR-92b-3p DLGAP2 0.29 0.00599 -2.48 0 MirTarget; miRNATAP -0.65 0 NA
57 hsa-miR-92b-3p DOCK5 0.29 0.00599 -0.71 0 MirTarget -0.12 0.02831 NA
58 hsa-miR-92b-3p DOK6 0.29 0.00599 -1.71 0 mirMAP -0.56 0 NA
59 hsa-miR-92b-3p DSEL 0.29 0.00599 -1.16 0 mirMAP -0.15 0.00051 NA
60 hsa-miR-92b-3p EBAG9 0.29 0.00599 -0.55 0 miRNATAP -0.18 0 NA
61 hsa-miR-92b-3p EDF1 0.29 0.00599 0.05 0.57384 miRNAWalker2 validate -0.17 0 NA
62 hsa-miR-92b-3p EFR3B 0.29 0.00599 0.38 0.00474 MirTarget -0.42 0 NA
63 hsa-miR-92b-3p EGR2 0.29 0.00599 -2.29 0 miRNATAP -0.29 0.00242 NA
64 hsa-miR-92b-3p EIF2B2 0.29 0.00599 -0.27 0.00019 miRNAWalker2 validate -0.27 0 NA
65 hsa-miR-92b-3p ESRRG 0.29 0.00599 -1.7 0 miRNATAP -0.52 0 NA
66 hsa-miR-92b-3p FAM126B 0.29 0.00599 -0.62 0 miRNATAP -0.11 0 NA
67 hsa-miR-92b-3p FAM81A 0.29 0.00599 -0.23 0.14526 miRNATAP -0.26 3.0E-5 NA
68 hsa-miR-92b-3p FHL2 0.29 0.00599 -1.49 0 miRNATAP -0.33 0 NA
69 hsa-miR-92b-3p FITM2 0.29 0.00599 -0.36 0.00075 mirMAP -0.1 0.01799 NA
70 hsa-miR-92b-3p FJX1 0.29 0.00599 1.98 0 miRNAWalker2 validate -0.12 0.0349 NA
71 hsa-miR-92b-3p FKBP1A 0.29 0.00599 -0.17 0.01127 miRNATAP -0.23 0 NA
72 hsa-miR-92b-3p FKBP4 0.29 0.00599 -0.43 0 miRNAWalker2 validate -0.25 0 NA
73 hsa-miR-92b-3p FLI1 0.29 0.00599 0.18 0.07149 miRNATAP -0.23 0 NA
74 hsa-miR-92b-3p FLRT2 0.29 0.00599 -1.56 0 mirMAP -0.15 0.02725 NA
75 hsa-miR-92b-3p FMN2 0.29 0.00599 -2.21 0 miRNATAP -0.47 3.0E-5 NA
76 hsa-miR-92b-3p FOXP2 0.29 0.00599 -3.3 0 miRNATAP -0.87 0 NA
77 hsa-miR-92b-3p FRY 0.29 0.00599 -0.58 0 MirTarget; miRNATAP -0.34 0 NA
78 hsa-miR-92b-3p FZD4 0.29 0.00599 -0.17 0.06159 mirMAP -0.41 0 NA
79 hsa-miR-92b-3p G6PD 0.29 0.00599 0.11 0.11544 miRNAWalker2 validate -0.12 7.0E-5 NA
80 hsa-miR-92b-3p GATA2 0.29 0.00599 0.09 0.4499 MirTarget; miRNATAP -0.46 0 NA
81 hsa-miR-92b-3p GFOD1 0.29 0.00599 -0.1 0.34628 mirMAP -0.11 0.00785 NA
82 hsa-miR-92b-3p GJC1 0.29 0.00599 1.21 0 mirMAP -0.44 0 NA
83 hsa-miR-92b-3p GNG4 0.29 0.00599 -0.42 0.04407 mirMAP -0.24 0.00526 NA
84 hsa-miR-92b-3p GOLGA1 0.29 0.00599 -0.45 0 MirTarget -0.13 0 NA
85 hsa-miR-92b-3p GPR158 0.29 0.00599 -1.42 0 miRNATAP -0.29 0.00889 NA
86 hsa-miR-92b-3p GPRIN2 0.29 0.00599 -0.82 0 mirMAP -0.13 0.00985 NA
87 hsa-miR-92b-3p GRAMD1B 0.29 0.00599 -1.11 0 miRNATAP -0.36 0 NA
88 hsa-miR-92b-3p GRK5 0.29 0.00599 -0.71 0 miRNATAP -0.17 0.00024 NA
89 hsa-miR-92b-3p GSTM3 0.29 0.00599 -1.51 0 miRNAWalker2 validate -0.68 0 NA
90 hsa-miR-92b-3p HAND2 0.29 0.00599 -2.17 0 miRNATAP -0.31 0.01181 NA
91 hsa-miR-92b-3p HIST1H2AM 0.29 0.00599 -0.36 0.03446 miRNAWalker2 validate -0.53 0 NA
92 hsa-miR-92b-3p IQGAP2 0.29 0.00599 -1.89 0 MirTarget; miRNATAP -0.74 0 NA
93 hsa-miR-92b-3p IRAK3 0.29 0.00599 -0.32 0.00298 mirMAP -0.15 0.00074 NA
94 hsa-miR-92b-3p ITGA5 0.29 0.00599 0.55 0 miRNATAP -0.18 0 NA
95 hsa-miR-92b-3p ITPR1 0.29 0.00599 -2.51 0 MirTarget; miRNATAP -0.77 0 NA
96 hsa-miR-92b-3p JUN 0.29 0.00599 -1.69 0 miRNATAP -0.28 5.0E-5 NA
97 hsa-miR-92b-3p KAT2B 0.29 0.00599 -0.3 0.00032 MirTarget -0.1 0.00225 NA
98 hsa-miR-92b-3p KCNA1 0.29 0.00599 -5.75 0 MirTarget; miRNATAP -0.86 0 NA
99 hsa-miR-92b-3p KLF2 0.29 0.00599 -0.6 0.0001 miRNATAP -0.46 0 NA
100 hsa-miR-92b-3p KLHL29 0.29 0.00599 -0.07 0.57802 MirTarget; miRNATAP -0.12 0.0233 NA
101 hsa-miR-92b-3p KSR1 0.29 0.00599 -0.92 0 mirMAP -0.29 0 NA
102 hsa-miR-92b-3p KSR2 0.29 0.00599 -0.38 0.00018 miRNATAP -0.18 1.0E-5 NA
103 hsa-miR-92b-3p LATS2 0.29 0.00599 -0.83 0 miRNATAP -0.15 1.0E-5 NA
104 hsa-miR-92b-3p LETM1 0.29 0.00599 0.21 0.00063 mirMAP -0.2 0 NA
105 hsa-miR-92b-3p LMO2 0.29 0.00599 -0.14 0.18995 MirTarget -0.36 0 NA
106 hsa-miR-92b-3p LMX1B 0.29 0.00599 -2.92 0 mirMAP -0.9 0 NA
107 hsa-miR-92b-3p LPP 0.29 0.00599 -0.94 0 miRNATAP -0.11 0.03283 NA
108 hsa-miR-92b-3p LRRC4 0.29 0.00599 1.44 0 miRNATAP -0.33 0 NA
109 hsa-miR-92b-3p LRRFIP2 0.29 0.00599 -0.55 0 MirTarget -0.15 0 NA
110 hsa-miR-92b-3p METRN 0.29 0.00599 -0.14 0.3621 miRNAWalker2 validate -0.48 0 NA
111 hsa-miR-92b-3p MOAP1 0.29 0.00599 -0.09 0.08925 miRNATAP -0.11 0 NA
112 hsa-miR-92b-3p MPP1 0.29 0.00599 -0.36 0 MirTarget -0.19 0 NA
113 hsa-miR-92b-3p MPPED2 0.29 0.00599 -3.52 0 mirMAP -1.28 0 NA
114 hsa-miR-92b-3p MRO 0.29 0.00599 -4.25 0 mirMAP -1.49 0 NA
115 hsa-miR-92b-3p MRPL53 0.29 0.00599 0.09 0.22226 miRNAWalker2 validate -0.11 0.00022 NA
116 hsa-miR-92b-3p MYLK4 0.29 0.00599 -0.98 0 mirMAP -0.17 0 NA
117 hsa-miR-185-5p NCAPG -0.39 0 0.95 0 MirTarget -0.55 0 NA
118 hsa-miR-30e-3p NCAPG -0.64 0 0.95 0 mirMAP -0.39 0 NA
119 hsa-miR-374a-5p NCAPG -0.67 0 0.95 0 mirMAP -0.34 0.003 NA
120 hsa-miR-374b-5p NCAPG -0.76 0 0.95 0 mirMAP -0.46 1.0E-5 NA
121 hsa-miR-421 NCAPG -0.4 0.00042 0.95 0 miRNAWalker2 validate -0.22 0.00182 NA
122 hsa-miR-92b-3p NCKAP5 0.29 0.00599 -0.82 0 MirTarget -0.22 0.0001 NA
123 hsa-miR-92b-3p NEBL 0.29 0.00599 -0.93 0 mirMAP -0.15 0.00025 NA
124 hsa-miR-92b-3p NEGR1 0.29 0.00599 -2.31 0 miRNATAP -0.35 6.0E-5 NA
125 hsa-miR-92b-3p NFIA 0.29 0.00599 -0.61 0 miRNATAP -0.35 0 NA
126 hsa-miR-92b-3p NFYC 0.29 0.00599 -0.14 0.0036 miRNATAP -0.17 0 NA
127 hsa-miR-92b-3p NKX2-3 0.29 0.00599 -0.72 0.04837 miRNATAP -0.52 0.0004 NA
128 hsa-miR-92b-3p NOS1 0.29 0.00599 -3.06 0 mirMAP -0.54 1.0E-5 NA
129 hsa-miR-92b-3p NOTCH1 0.29 0.00599 0.33 8.0E-5 miRNATAP -0.2 0 NA
130 hsa-miR-92b-3p ONECUT2 0.29 0.00599 -1.15 0 mirMAP -0.48 0 NA
131 hsa-miR-92b-3p PARK7 0.29 0.00599 -0.04 0.48153 miRNAWalker2 validate -0.16 0 NA
132 hsa-miR-92b-3p PCBD2 0.29 0.00599 -0.22 0 mirMAP -0.13 0 NA
133 hsa-miR-92b-3p PCDH11X 0.29 0.00599 -3.69 0 MirTarget; miRNATAP -0.39 0.00427 NA
134 hsa-miR-92b-3p PCDH19 0.29 0.00599 -0.5 0.00332 mirMAP -0.37 0 NA
135 hsa-miR-92b-3p PCMTD1 0.29 0.00599 -0.6 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 6.0E-5 NA
136 hsa-miR-92b-3p PDE4D 0.29 0.00599 -0.78 0 miRNATAP -0.19 0.00096 NA
137 hsa-miR-92b-3p PER2 0.29 0.00599 -0.65 0 MirTarget; miRNATAP -0.13 0.00035 NA
138 hsa-miR-92b-3p PIK3R3 0.29 0.00599 0.21 0.04724 MirTarget; miRNATAP -0.34 0 NA
139 hsa-miR-92b-3p PITPNC1 0.29 0.00599 0.29 0.01632 MirTarget -0.19 8.0E-5 NA
140 hsa-miR-92b-3p PITPNM2 0.29 0.00599 -0.64 0 MirTarget; miRNATAP -0.15 2.0E-5 NA
141 hsa-miR-92b-3p PKIA 0.29 0.00599 -1.19 0 mirMAP -0.3 0 NA
142 hsa-miR-92b-3p PLGLB2 0.29 0.00599 -0.44 0.0002 MirTarget -0.15 0.00191 NA
143 hsa-miR-92b-3p PPIL1 0.29 0.00599 -0.5 0 miRNAWalker2 validate -0.22 0 NA
144 hsa-miR-92b-3p PPM1L 0.29 0.00599 -1.58 0 mirMAP -0.46 0 NA
145 hsa-miR-92b-3p PRDM16 0.29 0.00599 -1.36 0 miRNATAP -0.27 1.0E-5 NA
146 hsa-miR-92b-3p PRDX5 0.29 0.00599 0.05 0.53414 miRNATAP -0.19 0 NA
147 hsa-miR-92b-3p PREX2 0.29 0.00599 -2.05 0 mirMAP -0.59 0 NA
148 hsa-miR-92b-3p PRKCE 0.29 0.00599 -1.04 0 miRNATAP -0.27 0 NA
149 hsa-miR-92b-3p PROX1 0.29 0.00599 -2.88 0 miRNATAP -0.47 1.0E-5 NA
150 hsa-miR-92b-3p PTGER3 0.29 0.00599 0.55 0.00017 mirMAP -0.12 0.04698 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 40 1402 3.193e-10 1.486e-06
2 CELL DEVELOPMENT 38 1426 6.38e-09 1.484e-05
3 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 41 1805 1.286e-07 0.0001496
4 BEHAVIOR 20 516 1.222e-07 0.0001496
5 POSITIVE REGULATION OF GENE EXPRESSION 39 1733 3.555e-07 0.0002757
6 RESPONSE TO ENDOGENOUS STIMULUS 35 1450 3.137e-07 0.0002757
7 SINGLE ORGANISM BEHAVIOR 16 384 9.268e-07 0.000539
8 ORGANONITROGEN COMPOUND METABOLIC PROCESS 39 1796 8.763e-07 0.000539
9 RESPONSE TO HORMONE 25 893 1.437e-06 0.0006687
10 NEGATIVE REGULATION OF MOLECULAR FUNCTION 28 1079 1.41e-06 0.0006687
11 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 20 616 1.959e-06 0.0008286
12 RESPONSE TO NITROGEN COMPOUND 24 859 2.462e-06 0.0009547
13 NEURON DIFFERENTIATION 24 874 3.314e-06 0.001186
14 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 26 1004 3.631e-06 0.001207
15 REGULATION OF CELL DIFFERENTIATION 33 1492 4.839e-06 0.001501
16 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 1784 5.176e-06 0.001505
17 CELLULAR RESPONSE TO HORMONE STIMULUS 18 552 6.177e-06 0.001639
18 GLAND DEVELOPMENT 15 395 6.341e-06 0.001639
19 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 31 1395 8.941e-06 0.002189
20 NEURON DEVELOPMENT 20 687 9.944e-06 0.002313
21 TRANSMISSION OF NERVE IMPULSE 6 54 1.237e-05 0.002617
22 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 25 1008 1.194e-05 0.002617
23 REGULATION OF PROTEIN MODIFICATION PROCESS 35 1710 1.301e-05 0.002631
24 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 8 116 1.575e-05 0.002931
25 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 25 1024 1.558e-05 0.002931
26 CAMP METABOLIC PROCESS 5 34 1.675e-05 0.002998
27 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 541 1.819e-05 0.003023
28 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 541 1.819e-05 0.003023
29 RESPONSE TO OXYGEN CONTAINING COMPOUND 30 1381 1.965e-05 0.003152
30 RESPONSE TO ORGANIC CYCLIC COMPOUND 23 917 2.305e-05 0.003575
31 MEMBRANE DEPOLARIZATION 6 61 2.517e-05 0.003615
32 MULTICELLULAR ORGANISMAL SIGNALING 8 123 2.412e-05 0.003615
33 CAMP MEDIATED SIGNALING 5 37 2.564e-05 0.003615
34 REGULATION OF BLOOD CIRCULATION 12 295 2.809e-05 0.003844
35 ACTION POTENTIAL 7 94 3.296e-05 0.004382
36 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 25 1087 4.185e-05 0.005409
37 CARDIAC MUSCLE TISSUE DEVELOPMENT 8 140 6.093e-05 0.007553
38 REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 1618 6.293e-05 0.007553
39 REGULATION OF TRANSMEMBRANE TRANSPORT 14 426 6.331e-05 0.007553
40 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 5 46 7.52e-05 0.008748
41 REGULATION OF NEURON DIFFERENTIATION 16 554 8.76e-05 0.009704
42 MYELOID CELL DIFFERENTIATION 9 189 8.742e-05 0.009704
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 16 328 1.122e-07 0.0001042
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 15 315 3.859e-07 0.0001793
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 21 629 6.823e-07 0.0002113
4 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 30 1199 1.201e-06 0.0002789
5 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 12 226 1.894e-06 0.0003519
6 REGULATORY REGION NUCLEIC ACID BINDING 23 818 3.657e-06 0.0005099
7 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 19 588 3.842e-06 0.0005099
8 SEQUENCE SPECIFIC DNA BINDING 26 1037 6.478e-06 0.0007523
9 DOUBLE STRANDED DNA BINDING 21 764 1.403e-05 0.001448
NumGOOverlapSizeP ValueAdj. P Value
1 VOLTAGE GATED CALCIUM CHANNEL COMPLEX 5 40 3.781e-05 0.007543
2 AXON 14 418 5.167e-05 0.007543
3 MAIN AXON 6 58 1.879e-05 0.007543
4 AXON PART 10 219 5.049e-05 0.007543

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 10 137 8.003e-07 4.161e-05
2 Calcium_signaling_pathway_hsa04020 10 182 1.03e-05 0.0002677
3 Oocyte_meiosis_hsa04114 7 124 0.0001906 0.003304
4 cAMP_signaling_pathway_hsa04024 8 198 0.0006485 0.008431
5 cGMP_PKG_signaling_pathway_hsa04022 7 163 0.0009877 0.01027
6 Gap_junction_hsa04540 4 88 0.01008 0.08736
7 Hippo_signaling_pathway_hsa04390 5 154 0.01626 0.1208
8 Cellular_senescence_hsa04218 5 160 0.01886 0.1226
9 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.03111 0.1797
10 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.04964 0.2438
11 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.05156 0.2438
12 Notch_signaling_pathway_hsa04330 2 48 0.07691 0.3333
13 AMPK_signaling_pathway_hsa04152 3 121 0.1096 0.4385
14 Focal_adhesion_hsa04510 4 199 0.1235 0.4393
15 Mitophagy_animal_hsa04137 2 65 0.128 0.4393
16 Rap1_signaling_pathway_hsa04015 4 206 0.1352 0.4393
17 Apoptosis_hsa04210 3 138 0.1457 0.4457
18 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.1616 0.4668
19 mTOR_signaling_pathway_hsa04150 3 151 0.1756 0.4733
20 Ras_signaling_pathway_hsa04014 4 232 0.1821 0.4733
21 ErbB_signaling_pathway_hsa04012 2 85 0.195 0.4827
22 Tight_junction_hsa04530 3 170 0.2218 0.5243
23 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.244 0.5364
24 HIF_1_signaling_pathway_hsa04066 2 100 0.2476 0.5364
25 TNF_signaling_pathway_hsa04668 2 108 0.2759 0.5738
26 Sphingolipid_signaling_pathway_hsa04071 2 118 0.3112 0.5997
27 MAPK_signaling_pathway_hsa04010 4 295 0.3114 0.5997
28 Cell_cycle_hsa04110 2 124 0.3322 0.6169
29 Autophagy_animal_hsa04140 2 128 0.3461 0.6206
30 FoxO_signaling_pathway_hsa04068 2 132 0.3599 0.6238
31 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.3838 0.6438
32 Wnt_signaling_pathway_hsa04310 2 146 0.4073 0.6452
33 Phagosome_hsa04145 2 152 0.4272 0.6452
34 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.4343 0.6452
35 Necroptosis_hsa04217 2 164 0.4657 0.6727

Quest ID: a577d8231c54bffbb58afa8e6e8e7545