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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-219a-5p AFAP1L2 0.09 0.03414 -0.07 0.06551 MirTarget -0.17 0.0135 NA
2 hsa-miR-219a-5p CBFA2T3 0.09 0.03414 -0.85 0 MirTarget -1.1 0.00017 NA
3 hsa-miR-219a-5p CD164 0.09 0.03414 -0.41 0 MirTarget -0.34 0.02819 NA
4 hsa-miR-219a-5p DENND2D 0.09 0.03414 -0.53 1.0E-5 MirTarget -1.29 0 NA
5 hsa-miR-219a-5p DOK6 0.09 0.03414 -0.13 0.00819 MirTarget -0.32 0.0002 NA
6 hsa-miR-219a-5p ETV5 0.09 0.03414 -0.29 0.02565 MirTarget -0.71 0.00196 NA
7 hsa-miR-219a-5p FURIN 0.09 0.03414 -0.17 0.02823 MirTarget -0.34 0.0112 NA
8 hsa-miR-219a-5p GBP5 0.09 0.03414 -0.51 0.0044 MirTarget -1.96 0 NA
9 hsa-miR-219a-5p KCNH8 0.09 0.03414 -0.15 0.41692 MirTarget -1.11 0.0005 NA
10 hsa-miR-219a-5p KRR1 0.09 0.03414 -0.08 0.06087 MirTarget -0.21 0.00553 NA
11 hsa-miR-219a-5p MFNG 0.09 0.03414 -0.23 3.0E-5 MirTarget -0.29 0.00239 NA
12 hsa-miR-219a-5p MYOCD 0.09 0.03414 -0.05 0.26494 MirTarget -0.25 0.00109 NA
13 hsa-miR-219a-5p PCYOX1L 0.09 0.03414 -0.08 0.47761 MirTarget -0.82 1.0E-5 NA
14 hsa-miR-219a-5p PDGFRA 0.09 0.03414 -1.04 0 MirTarget -2.39 0 NA
15 hsa-miR-219a-5p PIP5K1C 0.09 0.03414 0.13 0.02714 MirTarget -0.37 0.00038 NA
16 hsa-miR-219a-5p PKD2 0.09 0.03414 -0.26 0.01023 MirTarget -0.82 0 NA
17 hsa-miR-219a-5p PRG4 0.09 0.03414 -0.65 0.00113 MirTarget -0.95 0.00665 NA
18 hsa-miR-219a-5p RBMS3 0.09 0.03414 -0.3 0 MirTarget -0.35 0.00019 NA
19 hsa-miR-219a-5p ROR1 0.09 0.03414 0.06 0.68684 MirTarget -1 5.0E-5 NA
20 hsa-miR-219a-5p SCARB2 0.09 0.03414 -0.05 0.39068 MirTarget -0.32 0.00165 NA
21 hsa-miR-219a-5p SDK1 0.09 0.03414 -0.2 0.1614 MirTarget -0.61 0.01109 NA
22 hsa-miR-219a-5p SLC16A6 0.09 0.03414 -0.23 0.10105 MirTarget -0.65 0.00852 NA
23 hsa-miR-219a-5p SLCO4C1 0.09 0.03414 -1.1 2.0E-5 MirTarget -1.65 0.00023 NA
24 hsa-miR-219a-5p SSBP2 0.09 0.03414 -0.23 0.02384 MirTarget -1.03 0 NA
25 hsa-miR-219a-5p STK38L 0.09 0.03414 -0.14 0.04953 MirTarget -0.39 0.00184 NA
26 hsa-miR-219a-5p ZEB2 0.09 0.03414 -0.45 2.0E-5 MirTarget -1.33 0 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Lysosome_hsa04142 2 123 0.01107 0.3861
2 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.01534 0.3861
3 Focal_adhesion_hsa04510 2 199 0.02737 0.3861
4 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.0297 0.3861
5 Endocytosis_hsa04144 2 244 0.03975 0.4134

Quest ID: a753c7a700aba51823fa73630221aa04