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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-502-5p A2ML1 0.87 0.00123 -0.94 0.1549 MirTarget -0.5 0.00386 NA
2 hsa-let-7b-5p AARSD1 0.17 0.1606 -0.13 0.17714 miRNAWalker2 validate -0.18 0.00026 NA
3 hsa-let-7i-5p ABCC5 0.91 0 -0.7 0 miRNATAP -0.33 2.0E-5 NA
4 hsa-let-7a-5p ABHD14B 0.3 0.00963 -0.52 2.0E-5 MirTarget -0.2 0.003 NA
5 hsa-let-7e-5p ABHD14B 0.23 0.16229 -0.52 2.0E-5 MirTarget -0.26 0 NA
6 hsa-let-7f-5p ABHD14B 0.3 0.0221 -0.52 2.0E-5 MirTarget -0.16 0.00676 NA
7 hsa-let-7i-5p ABHD14B 0.91 0 -0.52 2.0E-5 MirTarget -0.23 0.00073 NA
8 hsa-let-7b-5p ABL1 0.17 0.1606 -0.21 0.07804 miRNAWalker2 validate -0.18 0.00351 NA
9 hsa-let-7g-5p ABL2 0.3 0.02968 0.82 0 miRNATAP -0.12 0.01548 NA
10 hsa-miR-1266-5p ACBD4 0.98 0.00203 -0.88 0 MirTarget -0.13 0 NA
11 hsa-let-7c-5p ACER2 -0.15 0.54808 -1.35 0 MirTarget -0.33 0 NA
12 hsa-let-7e-5p ACER2 0.23 0.16229 -1.35 0 MirTarget -0.47 2.0E-5 NA
13 hsa-let-7i-5p ACER2 0.91 0 -1.35 0 MirTarget -0.6 0.00011 NA
14 hsa-let-7b-5p ACSL6 0.17 0.1606 -1.59 0 miRNATAP -0.57 0.00096 NA
15 hsa-miR-502-5p ACSS3 0.87 0.00123 -0.4 0.15502 MirTarget -0.33 1.0E-5 NA
16 hsa-let-7b-5p ACTA1 0.17 0.1606 -0.34 0.3688 miRNATAP -0.44 0.02912 NA
17 hsa-let-7f-5p ACTA1 0.3 0.0221 -0.34 0.3688 miRNATAP -0.5 0.00591 NA
18 hsa-let-7g-5p ACTA1 0.3 0.02968 -0.34 0.3688 miRNATAP -0.97 0 NA
19 hsa-let-7i-5p ACTA1 0.91 0 -0.34 0.3688 miRNATAP -0.55 0.00809 NA
20 hsa-let-7f-5p ACVR2A 0.3 0.0221 -0.41 0.00039 miRNATAP -0.11 0.04456 NA
21 hsa-let-7g-5p ACVR2A 0.3 0.02968 -0.41 0.00039 miRNATAP -0.24 0 NA
22 hsa-let-7i-5p ACVR2A 0.91 0 -0.41 0.00039 miRNATAP -0.27 1.0E-5 NA
23 hsa-let-7e-5p ADAM15 0.23 0.16229 0.11 0.38755 miRNATAP -0.12 0.00942 NA
24 hsa-let-7f-5p ADAMTS15 0.3 0.0221 -1.47 1.0E-5 MirTarget; miRNATAP -0.32 0.04123 NA
25 hsa-let-7i-5p ADAMTS15 0.91 0 -1.47 1.0E-5 MirTarget; miRNATAP -0.4 0.02874 NA
26 hsa-miR-502-5p ADAMTS17 0.87 0.00123 -0.45 0.11385 MirTarget -0.17 0.02524 NA
27 hsa-let-7g-5p ADAMTS5 0.3 0.02968 0.19 0.27716 miRNATAP -0.39 0 NA
28 hsa-miR-1266-5p ADAMTS6 0.98 0.00203 1.2 0 MirTarget -0.21 0 NA
29 hsa-let-7a-5p ADAMTS8 0.3 0.00963 -1.48 0.00069 MirTarget; TargetScan; miRNATAP -0.76 0.00134 NA
30 hsa-let-7b-5p ADAMTS8 0.17 0.1606 -1.48 0.00069 MirTarget; miRNATAP -0.78 0.00061 NA
31 hsa-let-7f-5p ADAMTS8 0.3 0.0221 -1.48 0.00069 MirTarget; miRNATAP -0.64 0.00188 NA
32 hsa-let-7g-5p ADAMTS8 0.3 0.02968 -1.48 0.00069 MirTarget; miRNATAP -1.49 0 NA
33 hsa-let-7i-5p ADAMTS8 0.91 0 -1.48 0.00069 MirTarget; miRNATAP -1.03 1.0E-5 NA
34 hsa-miR-502-5p ADCY5 0.87 0.00123 -1.84 1.0E-5 miRNATAP -0.7 0 NA
35 hsa-let-7a-5p ADCY9 0.3 0.00963 -0.36 0.01911 TargetScan; miRNATAP -0.19 0.02328 NA
36 hsa-let-7f-5p ADCY9 0.3 0.0221 -0.36 0.01911 miRNATAP -0.28 0.00016 NA
37 hsa-let-7g-5p ADCY9 0.3 0.02968 -0.36 0.01911 miRNATAP -0.4 0 NA
38 hsa-let-7i-5p ADCY9 0.91 0 -0.36 0.01911 miRNATAP -0.19 0.02551 NA
39 hsa-miR-1266-5p ADD2 0.98 0.00203 -0.33 0.34514 MirTarget -0.51 0 NA
40 hsa-miR-502-5p ADHFE1 0.87 0.00123 -2.92 0 miRNATAP -0.53 0 NA
41 hsa-let-7a-5p ADRB2 0.3 0.00963 -2.78 0 MirTarget; TargetScan -0.56 0.00176 NA
42 hsa-let-7f-5p ADRB2 0.3 0.0221 -2.78 0 MirTarget -0.51 0.00093 NA
43 hsa-let-7g-5p ADRB2 0.3 0.02968 -2.78 0 MirTarget -0.68 0 NA
44 hsa-let-7i-5p ADRB2 0.91 0 -2.78 0 MirTarget -0.73 4.0E-5 NA
45 hsa-let-7a-5p ADRB3 0.3 0.00963 -2.9 0 MirTarget; TargetScan; miRNATAP -0.89 0.00134 NA
46 hsa-let-7f-5p ADRB3 0.3 0.0221 -2.9 0 MirTarget; miRNATAP -1 3.0E-5 NA
47 hsa-let-7g-5p ADRB3 0.3 0.02968 -2.9 0 MirTarget; miRNATAP -1.38 0 NA
48 hsa-let-7i-5p ADRB3 0.91 0 -2.9 0 MirTarget; miRNATAP -1.21 1.0E-5 NA
49 hsa-let-7c-5p AEN -0.15 0.54808 0.71 0 MirTarget -0.18 0 NA
50 hsa-miR-1266-5p AFF1 0.98 0.00203 -0.38 0.00053 MirTarget -0.15 0 NA
51 hsa-let-7a-5p AGAP1 0.3 0.00963 -0.05 0.72151 TargetScan -0.19 0.0084 NA
52 hsa-let-7e-5p AIFM1 0.23 0.16229 -0.04 0.71464 miRNATAP -0.19 2.0E-5 NA
53 hsa-let-7g-5p AKAP11 0.3 0.02968 0.2 0.09825 miRNAWalker2 validate -0.25 0 NA
54 hsa-let-7a-5p AKAP6 0.3 0.00963 -1.59 3.0E-5 MirTarget; TargetScan -0.74 0.00033 NA
55 hsa-let-7b-5p AKAP6 0.17 0.1606 -1.59 3.0E-5 MirTarget -0.93 0 NA
56 hsa-let-7f-5p AKAP6 0.3 0.0221 -1.59 3.0E-5 MirTarget -0.74 3.0E-5 NA
57 hsa-let-7g-5p AKAP6 0.3 0.02968 -1.59 3.0E-5 MirTarget -1.77 0 NA
58 hsa-let-7i-5p AKAP6 0.91 0 -1.59 3.0E-5 MirTarget -1.24 0 NA
59 hsa-let-7a-5p AKT2 0.3 0.00963 -0.16 0.09338 TargetScan -0.12 0.02058 NA
60 hsa-miR-502-5p AKT3 0.87 0.00123 -0.27 0.18865 PITA; miRNATAP -0.35 0 NA
61 hsa-let-7e-5p ALG13 0.23 0.16229 -0.14 0.17907 miRNAWalker2 validate -0.11 0.00566 NA
62 hsa-miR-502-5p ALPK3 0.87 0.00123 -0.07 0.79023 MirTarget -0.34 0 NA
63 hsa-let-7b-5p AMPH 0.17 0.1606 -0.92 5.0E-5 miRNAWalker2 validate -0.24 0.04099 NA
64 hsa-let-7i-5p AMT 0.91 0 -1.49 0 MirTarget -0.71 0 NA
65 hsa-let-7a-5p ANGPTL2 0.3 0.00963 -0.02 0.91748 TargetScan; miRNATAP -0.33 0.0082 NA
66 hsa-let-7f-5p ANGPTL2 0.3 0.0221 -0.02 0.91748 miRNATAP -0.47 1.0E-5 NA
67 hsa-let-7g-5p ANGPTL2 0.3 0.02968 -0.02 0.91748 miRNATAP -0.8 0 NA
68 hsa-miR-1266-5p ANK2 0.98 0.00203 -1.6 1.0E-5 MirTarget -0.72 0 NA
69 hsa-miR-502-5p ANK2 0.87 0.00123 -1.6 1.0E-5 PITA -0.63 0 NA
70 hsa-let-7i-5p ANKRD46 0.91 0 -0.07 0.51371 MirTarget -0.15 0.00511 NA
71 hsa-miR-1266-5p ANXA6 0.98 0.00203 -0.56 0.00587 MirTarget -0.29 0 NA
72 hsa-let-7c-5p AP1S1 -0.15 0.54808 0.36 0.02361 MirTarget -0.23 0 NA
73 hsa-let-7e-5p AP1S1 0.23 0.16229 0.36 0.02361 MirTarget; miRNATAP -0.23 0.00013 NA
74 hsa-let-7g-5p APPBP2 0.3 0.02968 -0.15 0.05098 miRNATAP -0.21 0 NA
75 hsa-let-7i-5p APPBP2 0.91 0 -0.15 0.05098 miRNATAP -0.12 0.00271 NA
76 hsa-let-7b-5p AR 0.17 0.1606 -1.55 0 miRNAWalker2 validate -0.48 0.00744 NA
77 hsa-miR-502-5p AR 0.87 0.00123 -1.55 0 mirMAP -0.59 0 NA
78 hsa-let-7a-5p ARG2 0.3 0.00963 -0.45 0 MirTarget; TargetScan -0.19 0.00016 NA
79 hsa-let-7b-5p ARG2 0.17 0.1606 -0.45 0 MirTarget -0.14 0.00559 NA
80 hsa-let-7e-5p ARG2 0.23 0.16229 -0.45 0 MirTarget -0.11 0.00278 NA
81 hsa-let-7f-5p ARG2 0.3 0.0221 -0.45 0 MirTarget -0.16 0.0003 NA
82 hsa-let-7g-5p ARG2 0.3 0.02968 -0.45 0 MirTarget -0.11 0.01117 NA
83 hsa-let-7i-5p ARG2 0.91 0 -0.45 0 MirTarget -0.21 3.0E-5 NA
84 hsa-let-7f-5p ARHGAP20 0.3 0.0221 -1.38 0 miRNATAP -0.41 0.00214 NA
85 hsa-let-7g-5p ARHGAP20 0.3 0.02968 -1.38 0 miRNATAP -1 0 NA
86 hsa-let-7i-5p ARHGAP20 0.91 0 -1.38 0 miRNATAP -0.35 0.02415 NA
87 hsa-let-7e-5p ARHGAP26 0.23 0.16229 0.4 0.00322 mirMAP -0.17 0.001 NA
88 hsa-let-7g-5p ARHGAP28 0.3 0.02968 -0.91 0.00013 MirTarget; miRNATAP -0.52 0 NA
89 hsa-let-7g-5p ARHGEF15 0.3 0.02968 0.19 0.25353 MirTarget; miRNATAP -0.28 0.00025 NA
90 hsa-let-7e-5p ARHGEF38 0.23 0.16229 2.23 0 miRNATAP -0.4 0.00227 NA
91 hsa-let-7b-5p ARID3A 0.17 0.1606 0.61 0.00544 miRNAWalker2 validate -0.28 0.0142 NA
92 hsa-let-7e-5p ARID3B 0.23 0.16229 -0.19 0.17003 miRNATAP -0.12 0.0244 NA
93 hsa-let-7a-5p ARL4D 0.3 0.00963 -1.91 0 TargetScan -0.45 0.01613 NA
94 hsa-let-7c-5p ARL6IP1 -0.15 0.54808 0.58 1.0E-5 miRNAWalker2 validate -0.24 0 NA
95 hsa-let-7g-5p ARMC8 0.3 0.02968 -0.11 0.17343 miRNATAP -0.11 0.00159 NA
96 hsa-let-7g-5p ARNT2 0.3 0.02968 -0.33 0.25851 mirMAP -0.43 0.00124 NA
97 hsa-let-7g-5p ARPP19 0.3 0.02968 0.11 0.27444 MirTarget; miRNATAP -0.19 1.0E-5 NA
98 hsa-let-7f-5p ARRDC4 0.3 0.0221 -1.01 0 MirTarget; miRNATAP -0.24 0.0036 NA
99 hsa-let-7g-5p ARRDC4 0.3 0.02968 -1.01 0 MirTarget; miRNATAP -0.41 0 NA
100 hsa-let-7i-5p ARRDC4 0.91 0 -1.01 0 MirTarget; miRNATAP -0.45 0 NA
101 hsa-miR-1266-5p ARRDC4 0.98 0.00203 -1.01 0 MirTarget -0.2 0 NA
102 hsa-let-7g-5p ASAP1 0.3 0.02968 0.66 0 miRNATAP -0.22 0.00023 NA
103 hsa-let-7a-5p ASIC1 0.3 0.00963 -0.41 0.13205 miRNATAP -0.31 0.03473 NA
104 hsa-let-7b-5p ASIC1 0.17 0.1606 -0.41 0.13205 miRNAWalker2 validate -0.29 0.04321 NA
105 hsa-let-7f-5p ASIC1 0.3 0.0221 -0.41 0.13205 miRNATAP -0.27 0.03432 NA
106 hsa-let-7g-5p ASIC1 0.3 0.02968 -0.41 0.13205 miRNATAP -0.61 0 NA
107 hsa-let-7i-5p ASIC1 0.91 0 -0.41 0.13205 miRNATAP -0.56 0.00014 NA
108 hsa-miR-1266-5p ASTN1 0.98 0.00203 -2.39 2.0E-5 MirTarget -0.94 0 NA
109 hsa-let-7e-5p ATG10 0.23 0.16229 -0.15 0.09321 MirTarget -0.1 0.00323 NA
110 hsa-let-7g-5p ATG10 0.3 0.02968 -0.15 0.09321 MirTarget -0.11 0.0078 NA
111 hsa-let-7f-5p ATL1 0.3 0.0221 -0.94 0 miRNAWalker2 validate -0.27 0.00066 NA
112 hsa-miR-1266-5p ATP10D 0.98 0.00203 -0.37 0.00764 MirTarget -0.12 0 NA
113 hsa-miR-502-5p ATP1A2 0.87 0.00123 -3.5 0 MirTarget -1.05 0 NA
114 hsa-let-7a-5p ATP2B4 0.3 0.00963 -0.64 0.00597 TargetScan; miRNATAP -0.34 0.00862 NA
115 hsa-let-7b-5p ATP2B4 0.17 0.1606 -0.64 0.00597 miRNATAP -0.34 0.00634 NA
116 hsa-let-7f-5p ATP2B4 0.3 0.0221 -0.64 0.00597 miRNATAP -0.45 4.0E-5 NA
117 hsa-let-7g-5p ATP2B4 0.3 0.02968 -0.64 0.00597 miRNATAP -1.01 0 NA
118 hsa-let-7i-5p ATP2B4 0.91 0 -0.64 0.00597 miRNATAP -0.49 0.00012 NA
119 hsa-let-7b-5p ATP6V0A1 0.17 0.1606 -0.2 0.04105 miRNAWalker2 validate -0.24 0 NA
120 hsa-let-7g-5p ATP8B4 0.3 0.02968 0.11 0.51328 MirTarget -0.21 0.00761 NA
121 hsa-let-7a-5p ATPAF1 0.3 0.00963 -0.5 0 TargetScan -0.13 0.00325 NA
122 hsa-let-7f-5p ATXN1 0.3 0.0221 -0.51 0.00026 miRNATAP -0.19 0.00547 NA
123 hsa-let-7g-5p ATXN1 0.3 0.02968 -0.51 0.00026 miRNATAP -0.38 0 NA
124 hsa-let-7i-5p ATXN1 0.91 0 -0.51 0.00026 miRNATAP -0.17 0.02586 NA
125 hsa-let-7g-5p ATXN1L 0.3 0.02968 -0.07 0.43241 mirMAP -0.13 0.00147 NA
126 hsa-miR-502-5p AUTS2 0.87 0.00123 -0.27 0.18068 PITA -0.12 0.01648 NA
127 hsa-let-7a-5p B3GAT3 0.3 0.00963 0.09 0.42199 TargetScan -0.27 1.0E-5 NA
128 hsa-let-7c-5p B3GNT7 -0.15 0.54808 -0.62 0.07193 MirTarget -0.25 0.00337 NA
129 hsa-let-7e-5p B3GNT7 0.23 0.16229 -0.62 0.07193 MirTarget -0.29 0.02987 NA
130 hsa-let-7i-5p B3GNT7 0.91 0 -0.62 0.07193 MirTarget -0.44 0.01994 NA
131 hsa-miR-502-5p BACH2 0.87 0.00123 -0.15 0.55909 PITA; miRNATAP -0.35 0 NA
132 hsa-let-7b-5p BAHD1 0.17 0.1606 -0.13 0.13262 miRNAWalker2 validate; miRNATAP -0.1 0.02122 NA
133 hsa-let-7g-5p BBX 0.3 0.02968 0.14 0.22968 miRNATAP -0.23 1.0E-5 NA
134 hsa-let-7g-5p BCAP29 0.3 0.02968 -0.09 0.29187 mirMAP; miRNATAP -0.25 0 NA
135 hsa-let-7i-5p BCAP29 0.91 0 -0.09 0.29187 mirMAP; miRNATAP -0.14 0.00205 NA
136 hsa-miR-502-5p BCL11A 0.87 0.00123 -0.93 0.0063 MirTarget; PITA; miRNATAP -0.25 0.00603 NA
137 hsa-let-7c-5p BCL2L1 -0.15 0.54808 0.54 0.00023 miRNAWalker2 validate; miRTarBase -0.17 0 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA
138 hsa-let-7f-5p BEGAIN 0.3 0.0221 -0.43 0.09912 MirTarget; miRNATAP -0.26 0.04111 NA
139 hsa-let-7g-5p BEGAIN 0.3 0.02968 -0.43 0.09912 MirTarget; miRNATAP -0.52 1.0E-5 NA
140 hsa-let-7a-5p BMPR1B 0.3 0.00963 -1.24 0.00562 miRNAWalker2 validate -0.78 0.00135 NA
141 hsa-let-7b-5p BNC2 0.17 0.1606 -0.49 0.09988 miRNATAP -0.32 0.04123 NA
142 hsa-let-7f-5p BNC2 0.3 0.0221 -0.49 0.09988 miRNATAP -0.45 0.00152 NA
143 hsa-let-7g-5p BNC2 0.3 0.02968 -0.49 0.09988 miRNATAP -1.17 0 NA
144 hsa-miR-502-5p BNC2 0.87 0.00123 -0.49 0.09988 PITA -0.52 0 NA
145 hsa-let-7g-5p BRD3 0.3 0.02968 0.37 0.00013 miRNATAP -0.21 0 NA
146 hsa-let-7e-5p BRI3 0.23 0.16229 -0.05 0.72918 miRNAWalker2 validate -0.13 0.00999 NA
147 hsa-let-7e-5p BRI3BP 0.23 0.16229 0.99 0 mirMAP -0.25 0.0011 NA
148 hsa-let-7a-5p BSN 0.3 0.00963 -0.09 0.75045 TargetScan -0.41 0.00913 NA
149 hsa-let-7i-5p BTBD3 0.91 0 -0.1 0.50084 miRNATAP -0.2 0.00833 NA
150 hsa-let-7g-5p BTBD9 0.3 0.02968 -0.17 0.08038 MirTarget; miRNATAP -0.1 0.0219 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 125 1402 3.013e-13 1.402e-09
2 REGULATION OF NEURON PROJECTION DEVELOPMENT 48 408 2.131e-09 4.958e-06
3 REGULATION OF CELL PROJECTION ORGANIZATION 57 558 1.284e-08 9.955e-06
4 REGULATION OF NEURON DIFFERENTIATION 57 554 9.93e-09 9.955e-06
5 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 88 1021 7.179e-09 9.955e-06
6 CELL DEVELOPMENT 112 1426 1.091e-08 9.955e-06
7 REGULATION OF CELL MORPHOGENESIS 55 552 5.413e-08 3.598e-05
8 MUSCLE STRUCTURE DEVELOPMENT 45 432 2.551e-07 0.0001079
9 NEURON DIFFERENTIATION 74 874 2.446e-07 0.0001079
10 REGULATION OF AXONOGENESIS 25 168 1.968e-07 0.0001079
11 CENTRAL NERVOUS SYSTEM DEVELOPMENT 74 872 2.236e-07 0.0001079
12 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 66 750 2.848e-07 0.0001104
13 HEAD DEVELOPMENT 63 709 3.82e-07 0.0001197
14 CELLULAR COMPONENT MORPHOGENESIS 75 900 3.765e-07 0.0001197
15 REGULATION OF CELL DEVELOPMENT 71 836 3.86e-07 0.0001197
16 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 50 513 4.28e-07 0.0001245
17 REGULATION OF DEVELOPMENTAL GROWTH 34 289 4.747e-07 0.0001274
18 TISSUE DEVELOPMENT 111 1518 5.148e-07 0.0001274
19 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 126 1784 5.204e-07 0.0001274
20 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 37 337 8.371e-07 0.0001947
21 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 118 1672 1.308e-06 0.0002897
22 MUSCLE ORGAN DEVELOPMENT 32 277 1.529e-06 0.0003235
23 ORGAN MORPHOGENESIS 69 841 1.945e-06 0.0003935
24 NEURON PROJECTION DEVELOPMENT 50 545 2.512e-06 0.000487
25 CARDIOVASCULAR SYSTEM DEVELOPMENT 65 788 3.251e-06 0.0005819
26 CIRCULATORY SYSTEM DEVELOPMENT 65 788 3.251e-06 0.0005819
27 REGULATION OF CELL DIFFERENTIATION 106 1492 3.576e-06 0.0006163
28 POSITIVE REGULATION OF NEURON DIFFERENTIATION 33 306 4.782e-06 0.0007947
29 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 49 554 8.623e-06 0.001337
30 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 27 232 8.604e-06 0.001337
31 PROTEOGLYCAN BIOSYNTHETIC PROCESS 12 58 1.008e-05 0.001487
32 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 32 303 1.022e-05 0.001487
33 REGULATION OF EXTENT OF CELL GROWTH 16 101 1.359e-05 0.001916
34 EMBRYO DEVELOPMENT 69 894 1.533e-05 0.002087
35 SKELETAL MUSCLE ORGAN DEVELOPMENT 19 137 1.587e-05 0.002087
36 TUBE DEVELOPMENT 48 552 1.66e-05 0.002087
37 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 36 368 1.618e-05 0.002087
38 CELL PART MORPHOGENESIS 53 633 1.756e-05 0.00215
39 CHONDROITIN SULFATE PROTEOGLYCAN METABOLIC PROCESS 10 43 1.867e-05 0.002228
40 NEURON PROJECTION MORPHOGENESIS 38 402 2.059e-05 0.002337
41 CELL PROJECTION ORGANIZATION 69 902 2.044e-05 0.002337
42 RESPONSE TO ENDOGENOUS STIMULUS 100 1450 2.346e-05 0.002481
43 PROTEOGLYCAN METABOLIC PROCESS 14 83 2.245e-05 0.002481
44 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 75 1008 2.294e-05 0.002481
45 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 14 84 2.583e-05 0.00267
46 RESPONSE TO HORMONE 68 893 2.712e-05 0.002744
47 VASCULATURE DEVELOPMENT 42 469 2.807e-05 0.002779
48 RESPONSE TO STIMULUS INVOLVED IN REGULATION OF MUSCLE ADAPTATION 6 15 3.183e-05 0.003044
49 MUCOPOLYSACCHARIDE METABOLIC PROCESS 16 108 3.206e-05 0.003044
50 REGULATION OF CELLULAR COMPONENT SIZE 33 337 3.532e-05 0.003287
51 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 62 801 3.823e-05 0.003488
52 NEURON DEVELOPMENT 55 687 4.252e-05 0.003765
53 REGULATION OF SODIUM ION TRANSPORT 13 77 4.332e-05 0.003765
54 REGULATION OF CELLULAR COMPONENT MOVEMENT 60 771 4.369e-05 0.003765
55 CHONDROITIN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS 8 30 4.467e-05 0.003779
56 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 57 724 4.926e-05 0.004093
57 REGULATION OF CELL GROWTH 36 391 5.841e-05 0.004712
58 BEHAVIOR 44 516 5.873e-05 0.004712
59 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 73 1004 6.206e-05 0.004894
60 NEURON PROJECTION GUIDANCE 23 205 6.935e-05 0.005378
61 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 88 1275 7.247e-05 0.005528
62 EMBRYONIC MORPHOGENESIS 45 539 7.993e-05 0.005903
63 REGULATION OF CELL PROLIFERATION 100 1496 7.92e-05 0.005903
64 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 101 1517 8.473e-05 0.00616
65 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 54 689 8.714e-05 0.006238
66 MEMBRANE DEPOLARIZATION 11 61 8.954e-05 0.006312
67 RESPONSE TO KETONE 21 182 9.456e-05 0.006349
68 APPENDAGE DEVELOPMENT 20 169 9.688e-05 0.006349
69 CHONDROITIN SULFATE BIOSYNTHETIC PROCESS 7 25 9.612e-05 0.006349
70 ACTION POTENTIAL 14 94 9.28e-05 0.006349
71 LIMB DEVELOPMENT 20 169 9.688e-05 0.006349
72 RESPONSE TO STEROID HORMONE 42 497 0.0001049 0.006778
73 REGULATION OF ACTIN FILAMENT BASED PROCESS 30 312 0.0001095 0.006981
74 POSITIVE REGULATION OF GENE EXPRESSION 112 1733 0.0001145 0.007198
75 REGULATION OF MUSCLE ADAPTATION 11 63 0.0001213 0.007526
76 POSITIVE REGULATION OF CELL DEVELOPMENT 40 472 0.0001432 0.008766
77 GROWTH 36 410 0.0001521 0.009191
78 RESPONSE TO ACID CHEMICAL 30 319 0.0001623 0.009652
79 CELL DEATH 71 1001 0.0001655 0.009652
80 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 107 1656 0.000166 0.009652
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 36 315 4.481e-07 0.0004163
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 91 1199 1.3e-06 0.0005528
3 MACROMOLECULAR COMPLEX BINDING 102 1399 1.785e-06 0.0005528
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 35 328 3.16e-06 0.0007338
5 ACTIN BINDING 39 393 5.179e-06 0.0008165
6 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 27 226 5.273e-06 0.0008165
7 MRNA BINDING 21 155 8.365e-06 0.00111
8 SEQUENCE SPECIFIC DNA BINDING 78 1037 1.069e-05 0.001241
9 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 52 629 2.96e-05 0.003055
10 CORE PROMOTER PROXIMAL REGION DNA BINDING 35 371 4.496e-05 0.004177
11 MRNA 3 UTR BINDING 10 48 5.175e-05 0.004371
12 CYTOSKELETAL PROTEIN BINDING 62 819 7.261e-05 0.005621
13 TRANSLATION REGULATOR ACTIVITY NUCLEIC ACID BINDING 6 18 0.0001049 0.007494
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 103 1151 3.875e-11 2.263e-08
2 NEURON PART 105 1265 1.778e-09 5.192e-07
3 SYNAPSE 71 754 6.521e-09 1.269e-06
4 NEURON PROJECTION 80 942 6.824e-08 9.963e-06
5 SYNAPSE PART 56 610 6.146e-07 7.178e-05
6 CELL PROJECTION 125 1786 9.354e-07 9.048e-05
7 EXOCYTIC VESICLE MEMBRANE 13 56 1.085e-06 9.048e-05
8 COMPLEX OF COLLAGEN TRIMERS 8 23 4.98e-06 0.0003635
9 VESICLE MEMBRANE 45 512 2.334e-05 0.001514
10 ANCHORING JUNCTION 43 489 3.484e-05 0.002035
11 PLASMA MEMBRANE REGION 69 929 5.172e-05 0.002742
12 SARCOLEMMA 17 125 5.633e-05 0.002742
13 POSTSYNAPSE 35 378 6.574e-05 0.002742
14 TRANSPORT VESICLE MEMBRANE 19 151 6.265e-05 0.002742
15 CELL LEADING EDGE 33 350 7.43e-05 0.002893
16 CELL SUBSTRATE JUNCTION 36 398 8.396e-05 0.002939
17 CELL CELL JUNCTION 35 383 8.554e-05 0.002939
18 AXON 37 418 0.0001051 0.003409
19 DENSE CORE GRANULE 5 13 0.0001885 0.005795
20 PRESYNAPSE 27 283 0.0002687 0.007846
21 CONTRACTILE FIBER 22 211 0.0002851 0.00793
22 CORTICAL CYTOSKELETON 12 81 0.0003042 0.008074
23 MEMBRANE REGION 77 1134 0.0003393 0.008614

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 21 137 1.121e-06 5.831e-05
2 Cellular_senescence_hsa04218 21 160 1.375e-05 0.0003575
3 ErbB_signaling_pathway_hsa04012 14 85 2.963e-05 0.0005103
4 MAPK_signaling_pathway_hsa04010 30 295 3.925e-05 0.0005103
5 cGMP_PKG_signaling_pathway_hsa04022 20 163 5.82e-05 0.0006053
6 FoxO_signaling_pathway_hsa04068 17 132 0.0001123 0.0009735
7 Focal_adhesion_hsa04510 21 199 0.0003299 0.002451
8 PI3K_Akt_signaling_pathway_hsa04151 31 352 0.0004044 0.002628
9 Autophagy_animal_hsa04140 15 128 0.0007705 0.004452
10 Endocytosis_hsa04144 23 244 0.000874 0.004545
11 Ras_signaling_pathway_hsa04014 22 232 0.001036 0.004896
12 TGF_beta_signaling_pathway_hsa04350 11 84 0.00153 0.006629
13 HIF_1_signaling_pathway_hsa04066 12 100 0.002046 0.008183
14 Regulation_of_actin_cytoskeleton_hsa04810 19 208 0.003357 0.01247
15 AMPK_signaling_pathway_hsa04152 13 121 0.003652 0.01266
16 mTOR_signaling_pathway_hsa04150 15 151 0.003989 0.01296
17 Oocyte_meiosis_hsa04114 13 124 0.004506 0.01378
18 Hippo_signaling_pathway_hsa04390 15 154 0.004793 0.01385
19 VEGF_signaling_pathway_hsa04370 8 59 0.005249 0.01436
20 Sphingolipid_signaling_pathway_hsa04071 12 118 0.007889 0.02051
21 Apoptosis_hsa04210 13 138 0.01084 0.02601
22 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 0.01148 0.02601
23 Cell_cycle_hsa04110 12 124 0.0115 0.02601
24 p53_signaling_pathway_hsa04115 8 68 0.01222 0.02649
25 Rap1_signaling_pathway_hsa04015 17 206 0.01403 0.02919
26 Gap_junction_hsa04540 9 88 0.01926 0.03852
27 cAMP_signaling_pathway_hsa04024 16 198 0.0201 0.03871
28 ECM_receptor_interaction_hsa04512 8 82 0.03392 0.06299
29 Phospholipase_D_signaling_pathway_hsa04072 12 146 0.03617 0.06485
30 Adherens_junction_hsa04520 7 72 0.04634 0.08032
31 Jak_STAT_signaling_pathway_hsa04630 12 162 0.06911 0.1159
32 Wnt_signaling_pathway_hsa04310 11 146 0.07229 0.1175
33 Tight_junction_hsa04530 12 170 0.09119 0.1437
34 Calcium_signaling_pathway_hsa04020 12 182 0.1316 0.2012
35 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.1455 0.2162
36 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.1684 0.2432
37 Mitophagy_animal_hsa04137 5 65 0.1765 0.2481
38 Apoptosis_multiple_species_hsa04215 3 33 0.1909 0.2613
39 Peroxisome_hsa04146 5 83 0.3314 0.4418
40 Autophagy_other_hsa04136 2 32 0.4344 0.5647
41 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.4982 0.6319
42 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.6381 0.7708
43 Hedgehog_signaling_pathway_hsa04340 2 47 0.6408 0.7708
44 Notch_signaling_pathway_hsa04330 2 48 0.6522 0.7708
45 Lysosome_hsa04142 5 123 0.6694 0.7735
46 Cytokine_cytokine_receptor_interaction_hsa04060 11 270 0.697 0.7759
47 Phagosome_hsa04145 6 152 0.7013 0.7759
48 TNF_signaling_pathway_hsa04668 4 108 0.7347 0.7959
49 Neuroactive_ligand_receptor_interaction_hsa04080 10 278 0.8239 0.8743
50 Necroptosis_hsa04217 4 164 0.946 0.946

Quest ID: a833b4f5689ffc24297312fd27b1a964