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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p APC2 -0.33 0.00046 1.72 0 TargetScan -0.3 0.00538 NA
2 hsa-miR-185-3p APC2 -0.27 0.0854 1.72 0 MirTarget -0.13 0.04272 NA
3 hsa-let-7g-3p AXIN2 -1.14 0 0.11 0.75298 MirTarget -0.33 0.01126 NA
4 hsa-miR-15b-5p AXIN2 0.23 0.08248 0.11 0.75298 MirTarget -0.45 0.00081 NA
5 hsa-miR-16-5p AXIN2 -0.4 0.0001 0.11 0.75298 MirTarget -0.49 0.00421 NA
6 hsa-miR-195-5p AXIN2 -1.86 0 0.11 0.75298 MirTarget -0.25 0.00506 NA
7 hsa-miR-26b-3p AXIN2 -1.26 0 0.11 0.75298 MirTarget -0.59 3.0E-5 NA
8 hsa-miR-424-5p AXIN2 -2.63 0 0.11 0.75298 MirTarget -0.19 0.03018 NA
9 hsa-miR-497-5p AXIN2 -1.41 0 0.11 0.75298 MirTarget -0.29 0.00329 NA
10 hsa-miR-616-3p AXIN2 -0.7 2.0E-5 0.11 0.75298 MirTarget -0.42 8.0E-5 NA
11 hsa-miR-15b-5p BTRC 0.23 0.08248 -0 0.97671 MirTarget -0.12 0 NA
12 hsa-miR-16-5p BTRC -0.4 0.0001 -0 0.97671 MirTarget -0.17 0 NA
13 hsa-miR-193a-3p BTRC -0.12 0.30939 -0 0.97671 MirTarget -0.15 0 NA
14 hsa-miR-361-3p BTRC 0.28 0.00549 -0 0.97671 MirTarget -0.1 0.00495 NA
15 hsa-miR-497-5p BTRC -1.41 0 -0 0.97671 MirTarget -0.11 0 NA
16 hsa-miR-505-3p BTRC -1.2 0 -0 0.97671 MirTarget -0.13 0 NA
17 hsa-miR-26b-3p CACYBP -1.26 0 0.95 0 MirTarget -0.26 0 NA
18 hsa-miR-30a-3p CACYBP -1.53 0 0.95 0 MirTarget -0.22 0 NA
19 hsa-miR-30e-3p CACYBP -1.21 0 0.95 0 MirTarget -0.35 0 NA
20 hsa-miR-21-3p CAMK2A -0.48 0.003 -0.33 0.35691 MirTarget -0.43 5.0E-5 NA
21 hsa-miR-25-3p CAMK2A 0.63 0 -0.33 0.35691 MirTarget -0.35 0.03714 NA
22 hsa-miR-7-1-3p CAMK2A -0.57 2.0E-5 -0.33 0.35691 MirTarget -0.36 0.00584 NA
23 hsa-miR-589-3p CAMK2B 1.17 0 -3.79 0 MirTarget -0.78 0 NA
24 hsa-miR-1976 CAMK2G -0.43 0.00325 0.58 0 MirTarget -0.1 8.0E-5 NA
25 hsa-miR-30e-3p CAMK2G -1.21 0 0.58 0 MirTarget -0.12 0.0001 NA
26 hsa-miR-628-5p CAMK2G -0.71 0 0.58 0 MirTarget -0.11 0.00024 NA
27 hsa-miR-106a-5p CCND1 -0.46 0.00972 -0.9 1.0E-5 MirTarget -0.26 0 NA
28 hsa-miR-106b-5p CCND1 0.65 0 -0.9 1.0E-5 MirTarget -0.43 0 NA
29 hsa-miR-1266-5p CCND1 1.63 0 -0.9 1.0E-5 MirTarget -0.23 0 NA
30 hsa-miR-15b-5p CCND1 0.23 0.08248 -0.9 1.0E-5 MirTarget -0.54 0 NA
31 hsa-miR-16-5p CCND1 -0.4 0.0001 -0.9 1.0E-5 MirTarget -0.31 0.00178 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
32 hsa-miR-17-5p CCND1 0.7 2.0E-5 -0.9 1.0E-5 MirTarget; TargetScan -0.34 0 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene
33 hsa-miR-193a-3p CCND1 -0.12 0.30939 -0.9 1.0E-5 MirTarget -0.21 0.01806 NA
34 hsa-miR-20a-5p CCND1 0.85 0 -0.9 1.0E-5 MirTarget -0.33 0 NA
35 hsa-miR-20b-5p CCND1 0.46 0.02859 -0.9 1.0E-5 MirTarget -0.23 0 NA
36 hsa-miR-503-5p CCND1 0.19 0.26842 -0.9 1.0E-5 MirTarget -0.16 0.00815 26047605; 23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC
37 hsa-miR-589-3p CCND1 1.17 0 -0.9 1.0E-5 MirTarget -0.18 0.00124 NA
38 hsa-miR-93-5p CCND1 1.4 0 -0.9 1.0E-5 MirTarget -0.34 0 NA
39 hsa-miR-942-5p CCND1 0.35 0.02833 -0.9 1.0E-5 MirTarget -0.25 0.00012 NA
40 hsa-miR-17-5p CCND2 0.7 2.0E-5 0.36 0.03656 TargetScan -0.11 0.02358 NA
41 hsa-miR-19b-3p CCND2 0.6 0.00017 0.36 0.03656 MirTarget -0.12 0.02082 NA
42 hsa-miR-33a-3p CCND2 -0.68 1.0E-5 0.36 0.03656 MirTarget -0.26 0 NA
43 hsa-miR-548v CCND2 -0.27 0.17626 0.36 0.03656 MirTarget -0.15 0.00034 NA
44 hsa-miR-501-3p CSNK1A1 1 0 -0.34 0 TargetScan -0.1 0 NA
45 hsa-miR-125b-5p CSNK2A1 -1.36 0 0.31 6.0E-5 MirTarget -0.15 0 NA
46 hsa-miR-618 CTBP2 0.14 0.51715 -0.39 0.02251 MirTarget -0.33 0 NA
47 hsa-miR-330-3p CTNNB1 -0.33 0.03161 0 0.98356 MirTarget -0.13 0 NA
48 hsa-miR-23a-3p CTNNBIP1 -0.18 0.13598 0.14 0.14796 MirTarget -0.19 0 NA
49 hsa-miR-29a-3p CTNNBIP1 -0.86 0 0.14 0.14796 MirTarget -0.13 0.00052 NA
50 hsa-miR-130b-3p DAAM1 0.69 0.00011 -0.82 3.0E-5 MirTarget -0.23 2.0E-5 NA
51 hsa-miR-130b-5p DAAM1 0.17 0.33761 -0.82 3.0E-5 MirTarget -0.13 0.01486 NA
52 hsa-miR-183-5p DAAM1 2.33 0 -0.82 3.0E-5 MirTarget -0.11 2.0E-5 NA
53 hsa-miR-301a-3p DAAM1 0.84 0 -0.82 3.0E-5 MirTarget -0.22 5.0E-5 NA
54 hsa-miR-362-3p DAAM1 0.81 0 -0.82 3.0E-5 MirTarget -0.2 0.00452 NA
55 hsa-miR-452-5p DAAM1 1.92 0 -0.82 3.0E-5 MirTarget -0.13 0.00058 NA
56 hsa-miR-500a-3p DAAM1 1.19 0 -0.82 3.0E-5 MirTarget -0.17 0.00798 NA
57 hsa-miR-548j-5p DAAM1 0.25 0.17136 -0.82 3.0E-5 MirTarget -0.2 0.00034 NA
58 hsa-miR-29b-2-5p DVL3 -0.22 0.08431 0.61 0 MirTarget -0.1 0.00053 NA
59 hsa-miR-22-3p EP300 -0.63 0 -0.2 0.07049 MirTarget -0.1 0.04632 NA
60 hsa-miR-30d-3p EP300 -0.12 0.32955 -0.2 0.07049 MirTarget -0.11 0.01494 NA
61 hsa-miR-342-3p EP300 -0.32 0.04498 -0.2 0.07049 MirTarget -0.11 0.00085 NA
62 hsa-miR-16-1-3p FBXW11 0.39 0.00112 0.05 0.54193 MirTarget -0.11 0.00045 NA
63 hsa-miR-19a-3p FOSL1 1.02 0 -1.29 0 MirTarget -0.17 0.00412 23831570 MicroRNA 19a 3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra 1 proto oncogene; In addition we could measure the activity of binding between miR-19a-3p and Fra-1 with a psiCHECK luciferase reporter system; Taken together these findings indicate that miR-19a-3p is capable of downregulating the M2 phenotype in M2 macrophages and that the low expression of this miRNA has an important role in the upregulation of Fra-1 expression and induction of M2 macrophage polarization
64 hsa-miR-19b-3p FOSL1 0.6 0.00017 -1.29 0 MirTarget -0.21 0.00535 NA
65 hsa-miR-22-3p FRAT2 -0.63 0 0.23 0.05124 MirTarget -0.23 1.0E-5 NA
66 hsa-miR-146b-5p FZD1 0.42 0.04574 -0.99 0 MirTarget -0.18 5.0E-5 NA
67 hsa-miR-616-5p FZD2 0.15 0.40284 0.41 0.07557 MirTarget -0.34 0 NA
68 hsa-miR-107 FZD3 0.24 0.01708 -0.43 0.07605 MirTarget -0.33 0.00541 NA
69 hsa-miR-17-5p FZD3 0.7 2.0E-5 -0.43 0.07605 MirTarget; TargetScan -0.24 0.00087 NA
70 hsa-miR-20a-5p FZD3 0.85 0 -0.43 0.07605 MirTarget -0.26 0.00012 NA
71 hsa-miR-23b-3p FZD3 -0.53 0 -0.43 0.07605 MirTarget -0.26 0.01785 NA
72 hsa-miR-30b-3p FZD3 -0.44 0.00095 -0.43 0.07605 MirTarget -0.25 0.00553 NA
73 hsa-miR-30d-5p FZD3 0.72 0 -0.43 0.07605 MirTarget -0.25 0.00569 NA
74 hsa-miR-30e-5p FZD3 -0.63 0 -0.43 0.07605 MirTarget -0.31 0.0078 NA
75 hsa-miR-3170 FZD3 -0.49 0.01029 -0.43 0.07605 MirTarget -0.13 0.03967 NA
76 hsa-let-7d-5p FZD4 0.05 0.70258 -0.35 0.01097 MirTarget -0.12 0.01989 NA
77 hsa-miR-17-3p FZD4 0.41 0.00422 -0.35 0.01097 MirTarget -0.25 0 NA
78 hsa-miR-17-5p FZD4 0.7 2.0E-5 -0.35 0.01097 TargetScan -0.3 0 NA
79 hsa-miR-185-5p FZD4 0.48 0 -0.35 0.01097 MirTarget -0.2 0.00363 NA
80 hsa-miR-3127-5p FZD4 0.84 0 -0.35 0.01097 MirTarget -0.18 1.0E-5 NA
81 hsa-miR-98-5p FZD4 -0.05 0.71591 -0.35 0.01097 MirTarget -0.1 0.03804 NA
82 hsa-miR-101-3p FZD6 -1.48 0 0.59 0.00374 MirTarget -0.31 1.0E-5 NA
83 hsa-miR-194-5p FZD6 -0.29 0.09961 0.59 0.00374 MirTarget -0.27 0 NA
84 hsa-miR-30c-1-3p FZD7 -1.39 0 -0.28 0.25656 MirTarget -0.24 0.00067 NA
85 hsa-miR-501-5p JUN 1.15 0 -1.6 0 MirTarget -0.2 0 NA
86 hsa-miR-23a-3p LRP5 -0.18 0.13598 -0.43 0.00037 MirTarget -0.17 0.00069 NA
87 hsa-miR-30d-3p MAP3K7 -0.12 0.32955 0.02 0.80074 MirTarget -0.15 1.0E-5 NA
88 hsa-miR-107 NFAT5 0.24 0.01708 -0.33 0.00164 MirTarget -0.12 0.02169 NA
89 hsa-miR-192-3p NFAT5 -0.64 0.00027 -0.33 0.00164 MirTarget -0.13 1.0E-5 NA
90 hsa-miR-30d-5p NFAT5 0.72 0 -0.33 0.00164 MirTarget -0.1 0.00926 NA
91 hsa-miR-548j-5p NFAT5 0.25 0.17136 -0.33 0.00164 MirTarget -0.11 5.0E-5 NA
92 hsa-miR-30d-5p NFATC2 0.72 0 -1.87 0 MirTarget -0.43 0.00143 NA
93 hsa-miR-15a-5p NFATC3 0.35 0.00077 -0.64 0 MirTarget -0.14 0.00111 NA
94 hsa-miR-185-5p NFATC3 0.48 0 -0.64 0 MirTarget -0.18 0.0001 NA
95 hsa-miR-222-3p NFATC3 1.09 0 -0.64 0 MirTarget -0.13 0 NA
96 hsa-miR-30d-5p NFATC3 0.72 0 -0.64 0 MirTarget -0.11 0.00162 NA
97 hsa-miR-200b-3p NKD1 -1.29 0.00027 0.62 0.18603 TargetScan -0.18 0.00545 NA
98 hsa-miR-140-5p NLK -0.22 0.01407 0.22 0.00116 MirTarget -0.1 0.00565 NA
99 hsa-miR-23a-3p NLK -0.18 0.13598 0.22 0.00116 MirTarget -0.18 0 NA
100 hsa-miR-511-5p NLK -1.75 0 0.22 0.00116 MirTarget -0.1 0 NA
101 hsa-miR-940 PPP2CB 0.45 0.01771 -0.89 0 MirTarget -0.11 9.0E-5 NA
102 hsa-miR-15a-5p PPP2R1B 0.35 0.00077 -0.37 0.01202 MirTarget -0.15 0.03047 NA
103 hsa-miR-15b-5p PPP2R1B 0.23 0.08248 -0.37 0.01202 MirTarget -0.17 0.00196 NA
104 hsa-miR-744-3p PPP2R1B -0.87 0 -0.37 0.01202 MirTarget -0.15 0.00079 NA
105 hsa-miR-197-3p PPP2R5A -0.25 0.03622 0.37 0.0002 MirTarget -0.16 0.00011 NA
106 hsa-miR-1976 PPP2R5D -0.43 0.00325 0.49 0 MirTarget -0.11 3.0E-5 NA
107 hsa-miR-19b-3p PPP2R5E 0.6 0.00017 -0.34 0.0006 MirTarget -0.11 0.00044 NA
108 hsa-miR-30d-3p PPP2R5E -0.12 0.32955 -0.34 0.0006 MirTarget -0.12 0.00209 NA
109 hsa-miR-17-3p PPP3CA 0.41 0.00422 -0.54 0 MirTarget -0.15 0 NA
110 hsa-miR-501-3p PPP3CA 1 0 -0.54 0 MirTarget -0.17 0 NA
111 hsa-miR-502-3p PPP3CA 0.66 0 -0.54 0 MirTarget -0.21 0 NA
112 hsa-miR-589-3p PPP3CA 1.17 0 -0.54 0 MirTarget -0.12 0 NA
113 hsa-miR-106b-5p PPP3R1 0.65 0 -0.35 0 MirTarget -0.14 0 NA
114 hsa-miR-181a-5p PPP3R1 0.25 0.05519 -0.35 0 MirTarget -0.14 0 NA
115 hsa-miR-181b-5p PPP3R1 0.49 0.00105 -0.35 0 MirTarget -0.14 0 NA
116 hsa-miR-181c-5p PPP3R1 -0.01 0.96913 -0.35 0 MirTarget -0.12 0 NA
117 hsa-miR-93-5p PPP3R1 1.4 0 -0.35 0 MirTarget -0.11 0 NA
118 hsa-miR-148a-3p PRICKLE2 -0.75 0 -1.36 0 MirTarget -0.36 1.0E-5 NA
119 hsa-miR-148b-3p PRICKLE2 0.27 0.00185 -1.36 0 MirTarget -0.46 0.00102 NA
120 hsa-miR-21-5p PRICKLE2 1.51 0 -1.36 0 MirTarget -0.23 0.00889 NA
121 hsa-miR-374a-3p PRICKLE2 -0.21 0.06235 -1.36 0 MirTarget -0.27 0.0136 NA
122 hsa-miR-589-5p PRICKLE2 1.19 0 -1.36 0 MirTarget -0.54 0 NA
123 hsa-miR-17-5p PRKACB 0.7 2.0E-5 -0.44 6.0E-5 TargetScan -0.14 1.0E-5 NA
124 hsa-miR-19b-3p PRKACB 0.6 0.00017 -0.44 6.0E-5 MirTarget -0.12 0.00048 NA
125 hsa-miR-361-5p PRKCB 0.23 0.00962 -1.62 0 MirTarget -0.42 0.00071 NA
126 hsa-miR-128-3p PRKX 0.29 0.01144 -0.24 0.24037 MirTarget -0.18 0.04321 NA
127 hsa-miR-148a-3p PRKX -0.75 0 -0.24 0.24037 MirTarget -0.59 0 NA
128 hsa-miR-16-1-3p PRKX 0.39 0.00112 -0.24 0.24037 MirTarget -0.24 0.00313 NA
129 hsa-miR-101-3p RAC1 -1.48 0 0.22 0.00293 MirTarget -0.16 0 25202416; 24649082; 25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR
130 hsa-miR-324-5p ROCK1 0.37 0.00592 -0.26 0.00576 MirTarget -0.13 0.00011 NA
131 hsa-miR-17-5p ROCK2 0.7 2.0E-5 -0.34 0.09781 TargetScan -0.23 0.00013 NA
132 hsa-miR-1301-3p SFRP1 1.12 0 -4.15 0 MirTarget -0.33 0.00114 NA
133 hsa-miR-146b-5p SFRP1 0.42 0.04574 -4.15 0 MirTarget -0.22 0.01408 NA
134 hsa-miR-16-1-3p SFRP1 0.39 0.00112 -4.15 0 MirTarget -0.72 0 NA
135 hsa-miR-192-3p SFRP1 -0.64 0.00027 -4.15 0 MirTarget -0.42 4.0E-5 NA
136 hsa-miR-548j-5p SFRP1 0.25 0.17136 -4.15 0 MirTarget -0.45 1.0E-5 NA
137 hsa-miR-940 SFRP1 0.45 0.01771 -4.15 0 MirTarget -0.25 0.01213 NA
138 hsa-miR-144-5p SFRP4 -1.55 0 2.13 0 MirTarget -0.35 0 NA
139 hsa-miR-3607-3p SFRP4 -2.16 0 2.13 0 MirTarget -0.34 1.0E-5 NA
140 hsa-miR-532-5p SFRP4 1.03 0 2.13 0 MirTarget -0.27 0.03865 NA
141 hsa-miR-7-1-3p SKP1 -0.57 2.0E-5 0.22 0.00211 MirTarget -0.11 2.0E-5 NA
142 hsa-miR-1976 SMAD3 -0.43 0.00325 0.31 0.00281 MirTarget -0.18 0 NA
143 hsa-miR-424-5p SMAD3 -2.63 0 0.31 0.00281 MirTarget -0.11 3.0E-5 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3
144 hsa-miR-29b-2-5p SMAD4 -0.22 0.08431 -0.31 8.0E-5 MirTarget -0.11 0.00032 NA
145 hsa-miR-142-3p TBL1X -1.42 0 -0.21 0.05381 MirTarget -0.1 0.00021 NA
146 hsa-miR-181a-5p TBL1X 0.25 0.05519 -0.21 0.05381 MirTarget -0.2 0 NA
147 hsa-miR-181b-5p TBL1X 0.49 0.00105 -0.21 0.05381 MirTarget -0.17 0 NA
148 hsa-miR-181c-5p TBL1X -0.01 0.96913 -0.21 0.05381 MirTarget -0.18 0 NA
149 hsa-miR-181d-5p TBL1X 0.16 0.36381 -0.21 0.05381 MirTarget -0.15 0 NA
150 hsa-miR-133a-3p TCF7 -0.63 0.01198 0.32 0.14929 MirTarget -0.21 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 41 351 9.794e-57 4.557e-53
2 CANONICAL WNT SIGNALING PATHWAY 21 95 5.311e-34 1.236e-30
3 NON CANONICAL WNT SIGNALING PATHWAY 21 140 3.743e-30 5.805e-27
4 REGULATION OF WNT SIGNALING PATHWAY 23 310 8.696e-26 1.012e-22
5 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 31 1021 2.007e-23 1.868e-20
6 EPITHELIUM DEVELOPMENT 29 945 6.782e-22 5.259e-19
7 REGULATION OF ORGAN MORPHOGENESIS 19 242 9.857e-22 6.552e-19
8 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 12 39 1.412e-21 8.214e-19
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 35 1672 1.703e-21 8.805e-19
10 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 20 365 9.439e-20 4.392e-17
11 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 14 110 3.753e-19 1.588e-16
12 POSITIVE REGULATION OF GENE EXPRESSION 33 1733 8.199e-19 3.179e-16
13 ORGAN MORPHOGENESIS 25 841 2.338e-18 8.369e-16
14 TUBE MORPHOGENESIS 18 323 6.403e-18 2.128e-15
15 TISSUE MORPHOGENESIS 21 533 8.363e-18 2.594e-15
16 MORPHOGENESIS OF AN EPITHELIUM 19 400 1.312e-17 3.815e-15
17 TUBE DEVELOPMENT 21 552 1.7e-17 4.653e-15
18 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 16 236 2.504e-17 6.132e-15
19 TISSUE DEVELOPMENT 30 1518 2.493e-17 6.132e-15
20 REGULATION OF EMBRYONIC DEVELOPMENT 13 114 3.417e-17 7.95e-15
21 REGULATION OF CELL DIFFERENTIATION 28 1492 1.723e-15 3.486e-13
22 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 28 1492 1.723e-15 3.486e-13
23 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 14 197 1.579e-15 3.486e-13
24 POSITIVE REGULATION OF RESPONSE TO STIMULUS 31 1929 1.927e-15 3.736e-13
25 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 8 22 2.156e-15 4.012e-13
26 POSITIVE REGULATION OF MOLECULAR FUNCTION 30 1791 2.286e-15 4.091e-13
27 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 30 1805 2.821e-15 4.862e-13
28 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 19 554 5.158e-15 8.571e-13
29 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 14 228 1.212e-14 1.945e-12
30 EMBRYO DEVELOPMENT 22 894 2.12e-14 3.288e-12
31 EMBRYONIC MORPHOGENESIS 18 539 4.852e-14 7.282e-12
32 REGULATION OF PROTEIN MODIFICATION PROCESS 28 1710 5.383e-14 7.828e-12
33 REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1618 1.182e-13 1.666e-11
34 SENSORY ORGAN DEVELOPMENT 17 493 1.653e-13 2.262e-11
35 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 28 1848 3.703e-13 4.923e-11
36 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 11 134 4.426e-13 5.721e-11
37 POSITIVE REGULATION OF CELL DIFFERENTIATION 20 823 5.472e-13 6.881e-11
38 ANTERIOR POSTERIOR PATTERN SPECIFICATION 12 194 1.042e-12 1.276e-10
39 GLAND DEVELOPMENT 15 395 1.378e-12 1.644e-10
40 NEURAL TUBE DEVELOPMENT 11 149 1.432e-12 1.666e-10
41 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 6 14 2.485e-12 2.82e-10
42 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 22 1135 2.575e-12 2.845e-10
43 DOPAMINERGIC NEURON DIFFERENTIATION 7 28 2.751e-12 2.845e-10
44 CARDIOVASCULAR SYSTEM DEVELOPMENT 19 788 2.733e-12 2.845e-10
45 CIRCULATORY SYSTEM DEVELOPMENT 19 788 2.733e-12 2.845e-10
46 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 22 1142 2.908e-12 2.942e-10
47 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 11 162 3.591e-12 3.555e-10
48 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 21 1036 4.016e-12 3.813e-10
49 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1036 4.016e-12 3.813e-10
50 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 12 220 4.614e-12 4.294e-10
51 REGULATION OF BINDING 13 283 4.776e-12 4.357e-10
52 NEGATIVE REGULATION OF CELL COMMUNICATION 22 1192 6.773e-12 6.061e-10
53 TUBE FORMATION 10 129 9.869e-12 8.665e-10
54 SENSORY ORGAN MORPHOGENESIS 12 239 1.22e-11 1.052e-09
55 REGULATION OF CELLULAR PROTEIN LOCALIZATION 16 552 1.313e-11 1.111e-09
56 REGULATION OF PROTEIN IMPORT 11 183 1.358e-11 1.128e-09
57 REGIONALIZATION 13 311 1.562e-11 1.275e-09
58 NEURAL TUBE FORMATION 9 94 1.684e-11 1.351e-09
59 POSITIVE REGULATION OF CELL COMMUNICATION 24 1532 1.751e-11 1.381e-09
60 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 13 323 2.507e-11 1.944e-09
61 FC EPSILON RECEPTOR SIGNALING PATHWAY 10 142 2.582e-11 1.969e-09
62 CELLULAR RESPONSE TO RETINOIC ACID 8 65 3.057e-11 2.294e-09
63 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 337 4.252e-11 3.14e-09
64 PATTERN SPECIFICATION PROCESS 14 418 4.521e-11 3.287e-09
65 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 10 152 5.084e-11 3.639e-09
66 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 1784 6.309e-11 4.448e-09
67 HEART MORPHOGENESIS 11 212 6.657e-11 4.623e-09
68 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 19 957 7.831e-11 5.358e-09
69 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 22 1360 8.826e-11 5.952e-09
70 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 11 218 8.983e-11 5.971e-09
71 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 162 9.56e-11 6.265e-09
72 CELL FATE COMMITMENT 11 227 1.386e-10 8.954e-09
73 NEURON DIFFERENTIATION 18 874 1.534e-10 9.776e-09
74 CELL DEVELOPMENT 22 1426 2.191e-10 1.378e-08
75 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 20 1152 2.374e-10 1.453e-08
76 REGULATION OF CATENIN IMPORT INTO NUCLEUS 6 27 2.371e-10 1.453e-08
77 CELL PROLIFERATION 16 672 2.408e-10 1.455e-08
78 MAMMARY GLAND EPITHELIUM DEVELOPMENT 7 53 3.365e-10 2.007e-08
79 EMBRYONIC ORGAN DEVELOPMENT 13 406 4.224e-10 2.488e-08
80 MIDBRAIN DEVELOPMENT 8 90 4.41e-10 2.565e-08
81 INNER EAR MORPHOGENESIS 8 92 5.27e-10 3.027e-08
82 REGULATION OF CELL CYCLE 18 949 5.776e-10 3.278e-08
83 REGULATION OF PROTEIN LOCALIZATION 18 950 5.874e-10 3.293e-08
84 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 513 6.61e-10 3.662e-08
85 REGULATION OF CELL DEVELOPMENT 17 836 6.719e-10 3.678e-08
86 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 9 144 7.951e-10 4.302e-08
87 RESPONSE TO OXYGEN CONTAINING COMPOUND 21 1381 8.373e-10 4.478e-08
88 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 21 1395 1.005e-09 5.271e-08
89 FC RECEPTOR SIGNALING PATHWAY 10 206 1.008e-09 5.271e-08
90 SOMITOGENESIS 7 62 1.05e-09 5.427e-08
91 NEUROGENESIS 21 1402 1.1e-09 5.627e-08
92 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 16 750 1.186e-09 5.999e-08
93 EMBRYONIC ORGAN MORPHOGENESIS 11 279 1.235e-09 6.181e-08
94 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1004 1.418e-09 7.019e-08
95 GASTRULATION 9 155 1.529e-09 7.487e-08
96 REGULATION OF CELL MORPHOGENESIS 14 552 1.702e-09 8.249e-08
97 RESPONSE TO RETINOIC ACID 8 107 1.778e-09 8.527e-08
98 HEART DEVELOPMENT 13 466 2.25e-09 1.068e-07
99 EAR MORPHOGENESIS 8 112 2.561e-09 1.192e-07
100 REGULATION OF OSTEOBLAST DIFFERENTIATION 8 112 2.561e-09 1.192e-07
101 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 12 381 2.589e-09 1.193e-07
102 REGULATION OF CELL DEATH 21 1472 2.646e-09 1.195e-07
103 POSITIVE REGULATION OF CELL DEVELOPMENT 13 472 2.625e-09 1.195e-07
104 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 16 799 2.942e-09 1.316e-07
105 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 16 801 3.049e-09 1.351e-07
106 REGULATION OF PROTEIN TARGETING 11 307 3.364e-09 1.477e-07
107 IMMUNE SYSTEM PROCESS 24 1984 3.523e-09 1.522e-07
108 REGULATION OF CELL PROLIFERATION 21 1496 3.533e-09 1.522e-07
109 MAMMARY GLAND DEVELOPMENT 8 117 3.627e-09 1.548e-07
110 PROTEIN PHOSPHORYLATION 17 944 4.212e-09 1.782e-07
111 DORSAL VENTRAL AXIS SPECIFICATION 5 20 4.274e-09 1.792e-07
112 CELLULAR RESPONSE TO ACID CHEMICAL 9 175 4.456e-09 1.851e-07
113 BETA CATENIN TCF COMPLEX ASSEMBLY 6 43 4.693e-09 1.933e-07
114 REGULATION OF OSSIFICATION 9 178 5.173e-09 2.111e-07
115 SOMITE DEVELOPMENT 7 78 5.418e-09 2.192e-07
116 POSITIVE REGULATION OF CELL DEATH 14 605 5.493e-09 2.203e-07
117 COCHLEA MORPHOGENESIS 5 21 5.596e-09 2.226e-07
118 INTRACELLULAR SIGNAL TRANSDUCTION 21 1572 8.521e-09 3.36e-07
119 DIGESTIVE TRACT MORPHOGENESIS 6 48 9.33e-09 3.648e-07
120 REGULATION OF CELLULAR LOCALIZATION 19 1277 9.593e-09 3.72e-07
121 MUSCLE STRUCTURE DEVELOPMENT 12 432 1.054e-08 4.054e-07
122 SEGMENTATION 7 89 1.375e-08 5.243e-07
123 AXIS SPECIFICATION 7 90 1.487e-08 5.625e-07
124 REGULATION OF TRANSPORT 22 1804 1.767e-08 6.63e-07
125 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 5 26 1.787e-08 6.652e-07
126 CELLULAR RESPONSE TO LIPID 12 457 1.965e-08 7.256e-07
127 NEGATIVE REGULATION OF GENE EXPRESSION 20 1493 2.066e-08 7.57e-07
128 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 20 1517 2.699e-08 9.812e-07
129 POSITIVE REGULATION OF CATALYTIC ACTIVITY 20 1518 2.729e-08 9.843e-07
130 RESPONSE TO GROWTH FACTOR 12 475 3.006e-08 1.076e-06
131 REGULATION OF TRANSFERASE ACTIVITY 16 946 3.184e-08 1.122e-06
132 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 154 3.163e-08 1.122e-06
133 REGULATION OF CYTOPLASMIC TRANSPORT 12 481 3.45e-08 1.207e-06
134 REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 6 60 3.694e-08 1.283e-06
135 REGULATION OF IMMUNE SYSTEM PROCESS 19 1403 4.363e-08 1.504e-06
136 MORPHOGENESIS OF A BRANCHING STRUCTURE 8 167 5.941e-08 2.033e-06
137 REGULATION OF IMMUNE RESPONSE 15 858 6.061e-08 2.058e-06
138 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 13 616 6.143e-08 2.071e-06
139 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 5 34 7.412e-08 2.412e-06
140 RESPONSE TO ENDOGENOUS STIMULUS 19 1450 7.362e-08 2.412e-06
141 REGULATION OF MESENCHYMAL CELL PROLIFERATION 5 34 7.412e-08 2.412e-06
142 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 67 7.237e-08 2.412e-06
143 REGULATION OF STEM CELL DIFFERENTIATION 7 113 7.256e-08 2.412e-06
144 REGULATION OF RESPONSE TO STRESS 19 1468 8.946e-08 2.891e-06
145 RESPONSE TO LIPID 15 888 9.49e-08 3.045e-06
146 REGULATION OF HYDROLASE ACTIVITY 18 1327 1.065e-07 3.394e-06
147 CELLULAR COMPONENT MORPHOGENESIS 15 900 1.13e-07 3.576e-06
148 MACROMOLECULAR COMPLEX DISASSEMBLY 8 182 1.155e-07 3.631e-06
149 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 1.163e-07 3.631e-06
150 COCHLEA DEVELOPMENT 5 39 1.515e-07 4.699e-06
151 MESENCHYME DEVELOPMENT 8 190 1.608e-07 4.922e-06
152 STEM CELL DIFFERENTIATION 8 190 1.608e-07 4.922e-06
153 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 4 16 1.686e-07 5.127e-06
154 REGULATION OF PHOSPHATASE ACTIVITY 7 128 1.711e-07 5.169e-06
155 EAR DEVELOPMENT 8 195 1.962e-07 5.879e-06
156 PHOSPHORYLATION 17 1228 1.971e-07 5.879e-06
157 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 7 131 2.005e-07 5.941e-06
158 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 13 684 2.058e-07 6.062e-06
159 CELL ACTIVATION 12 568 2.095e-07 6.132e-06
160 POSITIVE REGULATION OF CELL PROLIFERATION 14 814 2.205e-07 6.374e-06
161 ESTABLISHMENT OF TISSUE POLARITY 4 17 2.199e-07 6.374e-06
162 REGULATION OF JUN KINASE ACTIVITY 6 81 2.273e-07 6.529e-06
163 KIDNEY MORPHOGENESIS 6 82 2.446e-07 6.983e-06
164 POST ANAL TAIL MORPHOGENESIS 4 18 2.821e-07 8.003e-06
165 REGULATION OF EPITHELIAL CELL PROLIFERATION 9 285 2.963e-07 8.355e-06
166 CARDIAC SEPTUM DEVELOPMENT 6 85 3.033e-07 8.501e-06
167 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 983 3.517e-07 9.799e-06
168 REGULATION OF STEM CELL PROLIFERATION 6 88 3.73e-07 1.033e-05
169 CARDIAC CHAMBER DEVELOPMENT 7 144 3.82e-07 1.052e-05
170 RHYTHMIC PROCESS 9 298 4.31e-07 1.18e-05
171 EPITHELIAL CELL DIFFERENTIATION 11 495 4.348e-07 1.183e-05
172 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 21 1977 4.388e-07 1.187e-05
173 UROGENITAL SYSTEM DEVELOPMENT 9 299 4.432e-07 1.192e-05
174 DORSAL VENTRAL PATTERN FORMATION 6 91 4.554e-07 1.218e-05
175 DIGESTIVE SYSTEM DEVELOPMENT 7 148 4.6e-07 1.223e-05
176 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 15 1008 4.842e-07 1.28e-05
177 CARDIAC SEPTUM MORPHOGENESIS 5 49 4.895e-07 1.287e-05
178 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 740 5.042e-07 1.318e-05
179 REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 50 5.426e-07 1.395e-05
180 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 5 50 5.426e-07 1.395e-05
181 REGULATION OF INTRACELLULAR TRANSPORT 12 621 5.423e-07 1.395e-05
182 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 21 5.477e-07 1.4e-05
183 REGULATION OF CELL ADHESION 12 629 6.209e-07 1.579e-05
184 REPRODUCTIVE SYSTEM DEVELOPMENT 10 408 6.343e-07 1.595e-05
185 REGULATION OF ORGANELLE ORGANIZATION 16 1178 6.318e-07 1.595e-05
186 CELLULAR COMPONENT DISASSEMBLY 11 515 6.426e-07 1.608e-05
187 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 229 6.665e-07 1.658e-05
188 REGULATION OF DEPHOSPHORYLATION 7 158 7.157e-07 1.771e-05
189 REGULATION OF JNK CASCADE 7 159 7.468e-07 1.838e-05
190 RESPONSE TO ACID CHEMICAL 9 319 7.61e-07 1.864e-05
191 PROTEIN COMPLEX SUBUNIT ORGANIZATION 18 1527 8.519e-07 2.075e-05
192 REGULATION OF KINASE ACTIVITY 13 776 8.608e-07 2.086e-05
193 EYE DEVELOPMENT 9 326 9.114e-07 2.197e-05
194 EPITHELIAL TO MESENCHYMAL TRANSITION 5 56 9.639e-07 2.28e-05
195 POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY 4 24 9.655e-07 2.28e-05
196 OUTFLOW TRACT MORPHOGENESIS 5 56 9.639e-07 2.28e-05
197 REGULATION OF PROTEIN PHOSPHATASE TYPE 2A ACTIVITY 4 24 9.655e-07 2.28e-05
198 CARDIAC CHAMBER MORPHOGENESIS 6 104 1.004e-06 2.347e-05
199 POSITIVE REGULATION OF PROTEIN IMPORT 6 104 1.004e-06 2.347e-05
200 RESPONSE TO DRUG 10 431 1.043e-06 2.426e-05
201 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 1.123e-06 2.599e-05
202 CELL CYCLE PROCESS 15 1081 1.169e-06 2.693e-05
203 REGULATION OF CELL SUBSTRATE ADHESION 7 173 1.316e-06 3.017e-05
204 REGULATION OF CELL CYCLE PROCESS 11 558 1.408e-06 3.211e-05
205 EMBRYONIC DIGIT MORPHOGENESIS 5 61 1.483e-06 3.349e-05
206 POSITIVE REGULATION OF STEM CELL PROLIFERATION 5 61 1.483e-06 3.349e-05
207 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 27 1.583e-06 3.542e-05
208 AXIS ELONGATION 4 27 1.583e-06 3.542e-05
209 REGULATION OF CELLULAR RESPONSE TO STRESS 12 691 1.664e-06 3.704e-05
210 LOCOMOTION 15 1114 1.701e-06 3.768e-05
211 POSITIVE REGULATION OF JUN KINASE ACTIVITY 5 63 1.743e-06 3.844e-05
212 VENTRICULAR SEPTUM MORPHOGENESIS 4 28 1.843e-06 3.988e-05
213 SINGLE ORGANISM CELL ADHESION 10 459 1.837e-06 3.988e-05
214 GASTRULATION WITH MOUTH FORMING SECOND 4 28 1.843e-06 3.988e-05
215 MORPHOGENESIS OF A POLARIZED EPITHELIUM 4 28 1.843e-06 3.988e-05
216 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 117 2.003e-06 4.314e-05
217 IMMUNE SYSTEM DEVELOPMENT 11 582 2.117e-06 4.54e-05
218 HEAD DEVELOPMENT 12 709 2.172e-06 4.637e-05
219 LENS DEVELOPMENT IN CAMERA TYPE EYE 5 66 2.2e-06 4.675e-05
220 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 6 119 2.211e-06 4.677e-05
221 PROTEIN DEPHOSPHORYLATION 7 190 2.458e-06 5.176e-05
222 REGULATION OF CELL JUNCTION ASSEMBLY 5 68 2.554e-06 5.334e-05
223 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 2.557e-06 5.334e-05
224 CELL CYCLE 16 1316 2.709e-06 5.628e-05
225 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 1656 2.737e-06 5.661e-05
226 MUSCLE ORGAN DEVELOPMENT 8 277 2.768e-06 5.699e-05
227 REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 4 31 2.811e-06 5.763e-05
228 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 2.843e-06 5.802e-05
229 KIDNEY EPITHELIUM DEVELOPMENT 6 125 2.945e-06 5.943e-05
230 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 13 867 2.946e-06 5.943e-05
231 MUSCLE ORGAN MORPHOGENESIS 5 70 2.951e-06 5.943e-05
232 OSTEOBLAST DIFFERENTIATION 6 126 3.084e-06 6.186e-05
233 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 7 197 3.124e-06 6.213e-05
234 RESPIRATORY SYSTEM DEVELOPMENT 7 197 3.124e-06 6.213e-05
235 SKIN EPIDERMIS DEVELOPMENT 5 71 3.166e-06 6.269e-05
236 REGULATION OF ORGAN FORMATION 4 32 3.205e-06 6.32e-05
237 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 3.276e-06 6.431e-05
238 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 3.536e-06 6.912e-05
239 EMBRYONIC HEART TUBE DEVELOPMENT 5 73 3.635e-06 7.077e-05
240 MAINTENANCE OF CELL NUMBER 6 132 4.039e-06 7.831e-05
241 REGULATION OF CYTOSKELETON ORGANIZATION 10 502 4.078e-06 7.84e-05
242 NEURON PROJECTION GUIDANCE 7 205 4.064e-06 7.84e-05
243 BRAIN MORPHOGENESIS 4 34 4.114e-06 7.877e-05
244 REGULATION OF PROTEIN CATABOLIC PROCESS 9 393 4.227e-06 8.06e-05
245 MESENCHYMAL CELL DIFFERENTIATION 6 134 4.406e-06 8.369e-05
246 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 135 4.6e-06 8.695e-05
247 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 209 4.616e-06 8.695e-05
248 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 5 77 4.735e-06 8.883e-05
249 SKIN DEVELOPMENT 7 211 4.914e-06 9.183e-05
250 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 11 5.063e-06 9.423e-05
251 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 9 404 5.285e-06 9.798e-05
252 RESPONSE TO ORGANIC CYCLIC COMPOUND 13 917 5.432e-06 0.0001003
253 NEGATIVE REGULATION OF CELL PROLIFERATION 11 643 5.5e-06 0.0001012
254 REGULATION OF FIBROBLAST PROLIFERATION 5 81 6.08e-06 0.0001114
255 NEGATIVE REGULATION OF MOLECULAR FUNCTION 14 1079 6.182e-06 0.0001128
256 MESENCHYME MORPHOGENESIS 4 38 6.486e-06 0.0001179
257 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 3 12 6.735e-06 0.0001219
258 HAIR CYCLE 5 83 6.856e-06 0.0001232
259 MOLTING CYCLE 5 83 6.856e-06 0.0001232
260 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 5 84 7.272e-06 0.0001296
261 POSITIVE REGULATION OF OSSIFICATION 5 84 7.272e-06 0.0001296
262 PALATE DEVELOPMENT 5 85 7.708e-06 0.0001369
263 POSITIVE REGULATION OF CELL MATRIX ADHESION 4 40 7.991e-06 0.0001408
264 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 4 40 7.991e-06 0.0001408
265 ACTIVATION OF IMMUNE RESPONSE 9 427 8.254e-06 0.0001449
266 REGULATION OF SKELETAL MUSCLE ADAPTATION 3 13 8.736e-06 0.0001528
267 NEGATIVE REGULATION OF GROWTH 7 236 1.022e-05 0.0001767
268 REGULATION OF CELL MATRIX ADHESION 5 90 1.02e-05 0.0001767
269 MESONEPHROS DEVELOPMENT 5 90 1.02e-05 0.0001767
270 DEVELOPMENTAL GROWTH 8 333 1.068e-05 0.0001841
271 RESPONSE TO WOUNDING 10 563 1.114e-05 0.0001898
272 CONVERGENT EXTENSION 3 14 1.109e-05 0.0001898
273 POSITIVE REGULATION OF IMMUNE RESPONSE 10 563 1.114e-05 0.0001898
274 REGULATION OF DNA BINDING 5 93 1.197e-05 0.0002033
275 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 10 573 1.297e-05 0.0002195
276 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 5 95 1.328e-05 0.000224
277 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 7 246 1.337e-05 0.0002247
278 NEGATIVE REGULATION OF TRANSPORT 9 458 1.444e-05 0.0002416
279 RESPONSE TO CYTOKINE 11 714 1.473e-05 0.0002456
280 OSSIFICATION 7 251 1.523e-05 0.0002531
281 EPIDERMIS DEVELOPMENT 7 253 1.603e-05 0.0002655
282 REGULATION OF PROTEIN BINDING 6 168 1.61e-05 0.0002656
283 APPENDAGE DEVELOPMENT 6 169 1.665e-05 0.0002725
284 LIMB DEVELOPMENT 6 169 1.665e-05 0.0002725
285 ANTERIOR POSTERIOR AXIS SPECIFICATION 4 48 1.669e-05 0.0002725
286 CELL CYCLE PHASE TRANSITION 7 255 1.687e-05 0.0002744
287 PARAXIAL MESODERM DEVELOPMENT 3 16 1.699e-05 0.0002754
288 REGULATION OF MITOTIC CELL CYCLE 9 468 1.713e-05 0.0002768
289 NEGATIVE REGULATION OF CELL GROWTH 6 170 1.721e-05 0.0002771
290 VASCULATURE DEVELOPMENT 9 469 1.742e-05 0.0002795
291 WOUND HEALING 9 470 1.772e-05 0.0002816
292 NEGATIVE REGULATION OF CELL DEATH 12 872 1.773e-05 0.0002816
293 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 470 1.772e-05 0.0002816
294 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 258 1.819e-05 0.0002879
295 RESPONSE TO ALCOHOL 8 362 1.951e-05 0.0003077
296 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 103 1.968e-05 0.0003094
297 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 1.985e-05 0.000311
298 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 7 263 2.058e-05 0.0003199
299 REGULATION OF CHROMATIN BINDING 3 17 2.058e-05 0.0003199
300 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 5 104 2.062e-05 0.0003199
301 SEX DIFFERENTIATION 7 266 2.213e-05 0.0003421
302 RESPONSE TO HORMONE 12 893 2.244e-05 0.0003458
303 REGULATION OF FAT CELL DIFFERENTIATION 5 106 2.262e-05 0.0003473
304 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 2.464e-05 0.0003772
305 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 4 53 2.482e-05 0.0003786
306 PROTEASOMAL PROTEIN CATABOLIC PROCESS 7 271 2.494e-05 0.0003792
307 RESPONSE TO KETONE 6 182 2.53e-05 0.0003835
308 VENTRICULAR SEPTUM DEVELOPMENT 4 54 2.674e-05 0.000404
309 FORMATION OF PRIMARY GERM LAYER 5 110 2.705e-05 0.0004073
310 MITOTIC CELL CYCLE 11 766 2.82e-05 0.0004232
311 EPITHELIAL CELL DEVELOPMENT 6 186 2.86e-05 0.0004251
312 CELL CELL SIGNALING 11 767 2.854e-05 0.0004251
313 REGULATION OF CELLULAR COMPONENT BIOGENESIS 11 767 2.854e-05 0.0004251
314 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 2.92e-05 0.0004326
315 REGULATION OF CELLULAR COMPONENT MOVEMENT 11 771 2.993e-05 0.0004421
316 REGULATION OF GROWTH 10 633 3.047e-05 0.0004487
317 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 7 282 3.215e-05 0.000472
318 CELLULAR RESPONSE TO ALCOHOL 5 115 3.35e-05 0.0004871
319 NEPHRON DEVELOPMENT 5 115 3.35e-05 0.0004871
320 RESPONSE TO CALCIUM ION 5 115 3.35e-05 0.0004871
321 REGULATION OF CELL GROWTH 8 391 3.38e-05 0.0004899
322 POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 20 3.427e-05 0.0004921
323 PROTEIN AUTOPHOSPHORYLATION 6 192 3.417e-05 0.0004921
324 BRANCHING INVOLVED IN MAMMARY GLAND DUCT MORPHOGENESIS 3 20 3.427e-05 0.0004921
325 DEPHOSPHORYLATION 7 286 3.517e-05 0.0005035
326 EMBRYONIC PATTERN SPECIFICATION 4 58 3.553e-05 0.0005071
327 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 6 195 3.727e-05 0.0005304
328 REGULATION OF DEVELOPMENTAL GROWTH 7 289 3.758e-05 0.0005315
329 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 3.758e-05 0.0005315
330 MESODERM DEVELOPMENT 5 118 3.791e-05 0.0005346
331 STEM CELL PROLIFERATION 4 60 4.064e-05 0.0005713
332 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 6 199 4.175e-05 0.0005851
333 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 8 406 4.411e-05 0.0006164
334 SOMATIC STEM CELL DIVISION 3 22 4.608e-05 0.000642
335 EMBRYONIC HEART TUBE MORPHOGENESIS 4 62 4.627e-05 0.0006427
336 GROWTH 8 410 4.727e-05 0.0006546
337 ACTIVATION OF INNATE IMMUNE RESPONSE 6 204 4.795e-05 0.000662
338 REGULATION OF CARTILAGE DEVELOPMENT 4 63 4.929e-05 0.0006746
339 REGULATION OF EPIDERMIS DEVELOPMENT 4 63 4.929e-05 0.0006746
340 REGULATION OF MUSCLE ADAPTATION 4 63 4.929e-05 0.0006746
341 PROTEIN COMPLEX BIOGENESIS 13 1132 5.04e-05 0.0006857
342 PROTEIN COMPLEX ASSEMBLY 13 1132 5.04e-05 0.0006857
343 LEUKOCYTE ACTIVATION 8 414 5.061e-05 0.0006866
344 REGULATION OF OSTEOBLAST PROLIFERATION 3 23 5.287e-05 0.0007131
345 SCF DEPENDENT PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 3 23 5.287e-05 0.0007131
346 POSITIVE REGULATION OF BINDING 5 127 5.389e-05 0.0007247
347 HEPATICOBILIARY SYSTEM DEVELOPMENT 5 128 5.594e-05 0.0007501
348 SOMATIC STEM CELL POPULATION MAINTENANCE 4 66 5.921e-05 0.0007895
349 MESODERM MORPHOGENESIS 4 66 5.921e-05 0.0007895
350 IN UTERO EMBRYONIC DEVELOPMENT 7 311 5.976e-05 0.0007944
351 POSITIVE REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 3 24 6.029e-05 0.0007992
352 REGULATION OF ACTIN FILAMENT BASED PROCESS 7 312 6.098e-05 0.000806
353 CELL DEATH 12 1001 6.818e-05 0.0008987
354 NEGATIVE REGULATION OF CELL CYCLE 8 433 6.931e-05 0.000911
355 NEGATIVE REGULATION OF OSSIFICATION 4 69 7.052e-05 0.0009243
356 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 135 7.206e-05 0.0009418
357 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 437 7.39e-05 0.0009632
358 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 136 7.462e-05 0.0009632
359 NEURAL PRECURSOR CELL PROLIFERATION 4 70 7.461e-05 0.0009632
360 REGULATION OF PROTEIN STABILITY 6 221 7.473e-05 0.0009632
361 EYE MORPHOGENESIS 5 136 7.462e-05 0.0009632
362 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 71 7.888e-05 0.001014
363 RESPONSE TO NITROGEN COMPOUND 11 859 7.955e-05 0.00102
364 RESPONSE TO ABIOTIC STIMULUS 12 1024 8.472e-05 0.001083
365 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 3 27 8.653e-05 0.001097
366 DEVELOPMENTAL INDUCTION 3 27 8.653e-05 0.001097
367 NEGATIVE REGULATION OF AXON GUIDANCE 3 27 8.653e-05 0.001097
368 POSITIVE REGULATION OF PROTEIN BINDING 4 73 8.794e-05 0.001109
369 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 4 73 8.794e-05 0.001109
370 POSITIVE REGULATION OF CELL CYCLE 7 332 8.998e-05 0.001132
371 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 9.095e-05 0.001141
372 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 11 876 9.472e-05 0.001185
373 MAMMARY GLAND DUCT MORPHOGENESIS 3 28 9.669e-05 0.001206
374 SKELETAL SYSTEM DEVELOPMENT 8 455 9.782e-05 0.001217
375 REGULATION OF VASCULATURE DEVELOPMENT 6 233 9.997e-05 0.00124
376 SYNAPSE ORGANIZATION 5 145 0.000101 0.00125
377 REGULATION OF CATABOLIC PROCESS 10 731 0.0001016 0.001254
378 REGULATION OF CELLULAR RESPONSE TO HEAT 4 76 0.0001029 0.001267
379 STEM CELL DIVISION 3 29 0.0001076 0.001318
380 REGULATION OF HEART MORPHOGENESIS 3 29 0.0001076 0.001318
381 LYMPHOCYTE ACTIVATION 7 342 0.0001082 0.001319
382 REGULATION OF BMP SIGNALING PATHWAY 4 77 0.0001083 0.001319
383 PEPTIDYL SERINE MODIFICATION 5 148 0.0001113 0.001345
384 POSITIVE REGULATION OF CELL GROWTH 5 148 0.0001113 0.001345
385 MALE SEX DIFFERENTIATION 5 148 0.0001113 0.001345
386 TAXIS 8 464 0.000112 0.00135
387 POSITIVE REGULATION OF GROWTH 6 238 0.0001123 0.00135
388 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 8 465 0.0001137 0.001362
389 RENAL TUBULE DEVELOPMENT 4 78 0.0001139 0.001362
390 POSITIVE REGULATION OF MAPK CASCADE 8 470 0.0001224 0.00146
391 RESPONSE TO INORGANIC SUBSTANCE 8 479 0.0001394 0.001659
392 REGULATION OF INNATE IMMUNE RESPONSE 7 357 0.0001411 0.001675
393 NIK NF KAPPAB SIGNALING 4 83 0.000145 0.001716
394 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 0.0001486 0.001755
395 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 4 84 0.0001518 0.001789
396 POSITIVE REGULATION OF PROTEOLYSIS 7 363 0.0001564 0.001838
397 EMBRYONIC AXIS SPECIFICATION 3 33 0.0001592 0.001857
398 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 3 33 0.0001592 0.001857
399 POSITIVE REGULATION OF DEFENSE RESPONSE 7 364 0.0001591 0.001857
400 LEUKOCYTE CELL CELL ADHESION 6 255 0.0001636 0.001903
401 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 13 1275 0.0001677 0.001945
402 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 7 368 0.0001701 0.001969
403 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 7 370 0.0001759 0.002031
404 CELL SUBSTRATE ADHESION 5 164 0.00018 0.002073
405 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 262 0.0001894 0.002161
406 BONE REMODELING 3 35 0.0001901 0.002161
407 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 5 166 0.0001904 0.002161
408 RESPONSE TO MINERALOCORTICOID 3 35 0.0001901 0.002161
409 EPITHELIAL CELL PROLIFERATION 4 89 0.0001899 0.002161
410 INNER EAR RECEPTOR CELL DEVELOPMENT 3 35 0.0001901 0.002161
411 POSITIVE REGULATION OF CELL ADHESION 7 376 0.0001941 0.002197
412 CELLULAR RESPONSE TO EXTERNAL STIMULUS 6 264 0.0001974 0.002229
413 NEPHRON EPITHELIUM DEVELOPMENT 4 93 0.0002249 0.002527
414 REGULATION OF CELL SIZE 5 172 0.0002246 0.002527
415 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 8 514 0.0002254 0.002527
416 REGULATION OF MAPK CASCADE 9 660 0.0002391 0.002675
417 NEGATIVE REGULATION OF AXON EXTENSION 3 38 0.0002434 0.002697
418 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 4 95 0.000244 0.002697
419 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 4 95 0.000244 0.002697
420 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 5 175 0.0002433 0.002697
421 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 38 0.0002434 0.002697
422 POSITIVE REGULATION OF CATABOLIC PROCESS 7 395 0.0002621 0.00289
423 REGULATION OF AXON GUIDANCE 3 39 0.0002631 0.002894
424 GLAND MORPHOGENESIS 4 97 0.0002643 0.002901
425 REGULATION OF CHEMOTAXIS 5 180 0.0002771 0.003034
426 MAMMARY GLAND MORPHOGENESIS 3 40 0.0002837 0.003099
427 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 4 99 0.0002858 0.003114
428 NEURON PROJECTION MORPHOGENESIS 7 402 0.0002915 0.003169
429 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 0.000297 0.003221
430 CELL MOTILITY 10 835 0.0002987 0.003224
431 LOCALIZATION OF CELL 10 835 0.0002987 0.003224
432 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 3 41 0.0003054 0.003282
433 PROSTATE GLAND DEVELOPMENT 3 41 0.0003054 0.003282
434 REGULATION OF EXTENT OF CELL GROWTH 4 101 0.0003085 0.0033
435 CAMERA TYPE EYE MORPHOGENESIS 4 101 0.0003085 0.0033
436 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 0.0003203 0.003419
437 NEURON DEVELOPMENT 9 687 0.0003213 0.003421
438 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 3 42 0.0003282 0.003463
439 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 42 0.0003282 0.003463
440 EPITHELIAL CELL MORPHOGENESIS 3 42 0.0003282 0.003463
441 GENITALIA DEVELOPMENT 3 42 0.0003282 0.003463
442 REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 103 0.0003325 0.003492
443 REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 103 0.0003325 0.003492
444 NEURON PROJECTION DEVELOPMENT 8 545 0.0003343 0.003503
445 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 43 0.000352 0.003681
446 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 190 0.0003554 0.003708
447 CELLULAR RESPONSE TO HORMONE STIMULUS 8 552 0.000364 0.003789
448 CARDIAC VENTRICLE DEVELOPMENT 4 106 0.0003709 0.003844
449 FAT CELL DIFFERENTIATION 4 106 0.0003709 0.003844
450 REGULATION OF NEURON DIFFERENTIATION 8 554 0.0003729 0.003856
451 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 3 44 0.0003769 0.003888
452 BIOLOGICAL ADHESION 11 1032 0.0003933 0.004048
453 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0003982 0.00409
454 LUNG MORPHOGENESIS 3 45 0.0004029 0.00412
455 REGULATION OF EPIDERMAL CELL DIFFERENTIATION 3 45 0.0004029 0.00412
456 NEGATIVE REGULATION OF CELL DEVELOPMENT 6 303 0.0004126 0.004176
457 MACROMOLECULAR COMPLEX ASSEMBLY 13 1398 0.0004118 0.004176
458 REGULATION OF PROTEOLYSIS 9 711 0.0004129 0.004176
459 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.0004124 0.004176
460 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 303 0.0004126 0.004176
461 REGULATION OF CYTOKINE PRODUCTION 8 563 0.0004151 0.004189
462 REGULATION OF CHONDROCYTE DIFFERENTIATION 3 46 0.00043 0.004331
463 CELL CYCLE G1 S PHASE TRANSITION 4 111 0.0004419 0.004431
464 G1 S TRANSITION OF MITOTIC CELL CYCLE 4 111 0.0004419 0.004431
465 SKELETAL SYSTEM MORPHOGENESIS 5 201 0.0004598 0.004601
466 RESPONSE TO OXYGEN LEVELS 6 311 0.0004736 0.004728
467 POSITIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 3 48 0.0004877 0.00486
468 FEMALE SEX DIFFERENTIATION 4 116 0.000522 0.00519
469 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 207 0.0005256 0.005204
470 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 0.0005256 0.005204
471 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 4 117 0.0005392 0.005315
472 SPECIFICATION OF SYMMETRY 4 117 0.0005392 0.005315
473 REGULATION OF CELL CELL ADHESION MEDIATED BY CADHERIN 2 11 0.0005442 0.00532
474 REGULATION OF MAP KINASE ACTIVITY 6 319 0.0005413 0.00532
475 OLFACTORY BULB INTERNEURON DEVELOPMENT 2 11 0.0005442 0.00532
476 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 2 11 0.0005442 0.00532
477 CELL PROJECTION ORGANIZATION 10 902 0.0005486 0.005352
478 RHO PROTEIN SIGNAL TRANSDUCTION 3 50 0.0005502 0.005356
479 POSITIVE REGULATION OF HYDROLASE ACTIVITY 10 905 0.000563 0.005469
480 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 3 51 0.0005832 0.00563
481 NEGATIVE REGULATION OF CHEMOTAXIS 3 51 0.0005832 0.00563
482 MECHANORECEPTOR DIFFERENTIATION 3 51 0.0005832 0.00563
483 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 121 0.000612 0.005896
484 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 52 0.0006175 0.005937
485 CELLULAR RESPONSE TO INTERFERON GAMMA 4 122 0.0006312 0.006056
486 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 5 216 0.0006374 0.006103
487 CELL DIVISION 7 460 0.0006522 0.006139
488 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.0006517 0.006139
489 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 3 53 0.0006531 0.006139
490 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0006517 0.006139
491 MESONEPHRIC TUBULE MORPHOGENESIS 3 53 0.0006531 0.006139
492 TRACHEA MORPHOGENESIS 2 12 0.0006517 0.006139
493 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0006517 0.006139
494 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 2 12 0.0006517 0.006139
495 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 2 12 0.0006517 0.006139
496 REGULATION OF DEFENSE RESPONSE 9 759 0.0006611 0.006202
497 RESPONSE TO ESTROGEN 5 218 0.0006645 0.006221
498 RESPONSE TO METAL ION 6 333 0.0006779 0.006334
499 CELL CELL ADHESION 8 608 0.0006885 0.00642
500 POSITIVE REGULATION OF TRANSPORT 10 936 0.0007308 0.006801
501 SMAD PROTEIN SIGNAL TRANSDUCTION 3 56 0.0007676 0.007082
502 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 0.0007676 0.007082
503 REGULATION OF CELL FATE SPECIFICATION 2 13 0.0007686 0.007082
504 GANGLION DEVELOPMENT 2 13 0.0007686 0.007082
505 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0007686 0.007082
506 REGULATION OF REPRODUCTIVE PROCESS 4 129 0.0007781 0.007155
507 APOPTOTIC MITOCHONDRIAL CHANGES 3 57 0.0008084 0.007419
508 REGULATION OF HORMONE LEVELS 7 478 0.0008171 0.007484
509 PROTEIN STABILIZATION 4 131 0.0008242 0.007519
510 NEGATIVE REGULATION OF BINDING 4 131 0.0008242 0.007519
511 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 4 132 0.0008479 0.007721
512 REGULATION OF CELL ACTIVATION 7 484 0.0008789 0.007973
513 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 5 232 0.0008791 0.007973
514 CELL PART MORPHOGENESIS 8 633 0.0008944 0.008019
515 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 5 233 0.0008962 0.008019
516 CELL MIGRATION INVOLVED IN GASTRULATION 2 14 0.0008949 0.008019
517 VASCULOGENESIS 3 59 0.0008941 0.008019
518 REGULATION OF MONOCYTE DIFFERENTIATION 2 14 0.0008949 0.008019
519 CELLULAR RESPONSE TO VITAMIN D 2 14 0.0008949 0.008019
520 MIDGUT DEVELOPMENT 2 14 0.0008949 0.008019
521 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 60 0.000939 0.008386
522 MUSCLE CELL DIFFERENTIATION 5 237 0.000967 0.008619
523 NEGATIVE REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 2 15 0.00103 0.009098
524 OLFACTORY BULB INTERNEURON DIFFERENTIATION 2 15 0.00103 0.009098
525 RESPONSE TO STEROID HORMONE 7 497 0.001025 0.009098
526 REGULATION OF EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 2 15 0.00103 0.009098
527 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.00103 0.009098
528 REGULATION OF SMOOTHENED SIGNALING PATHWAY 3 62 0.001033 0.009104
529 REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 363 0.00106 0.009324
530 BLOOD VESSEL MORPHOGENESIS 6 364 0.001075 0.009439
531 PLATELET ACTIVATION 4 142 0.001112 0.009748
532 CELLULAR RESPONSE TO NITROGEN COMPOUND 7 505 0.001125 0.009838
533 RAS PROTEIN SIGNAL TRANSDUCTION 4 143 0.001142 0.009948
534 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 4 143 0.001142 0.009948
NumGOOverlapSizeP ValueAdj. P Value
1 BETA CATENIN BINDING 13 84 5.3e-19 4.924e-16
2 WNT ACTIVATED RECEPTOR ACTIVITY 9 22 9.418e-18 3.972e-15
3 FRIZZLED BINDING 10 36 1.283e-17 3.972e-15
4 WNT PROTEIN BINDING 9 31 3.733e-16 8.67e-14
5 PROTEIN DOMAIN SPECIFIC BINDING 16 624 8.109e-11 1.507e-08
6 G PROTEIN COUPLED RECEPTOR BINDING 10 259 9.139e-09 1.415e-06
7 PROTEIN SERINE THREONINE KINASE ACTIVITY 12 445 1.464e-08 1.943e-06
8 ENZYME BINDING 21 1737 4.875e-08 5.661e-06
9 PROTEIN KINASE ACTIVITY 13 640 9.573e-08 9.881e-06
10 SMAD BINDING 6 72 1.119e-07 1.04e-05
11 RECEPTOR AGONIST ACTIVITY 4 16 1.686e-07 1.424e-05
12 REGULATORY REGION NUCLEIC ACID BINDING 14 818 2.341e-07 1.812e-05
13 PDZ DOMAIN BINDING 6 90 4.264e-07 3.047e-05
14 PROTEIN PHOSPHATASE TYPE 2A REGULATOR ACTIVITY 4 21 5.477e-07 3.635e-05
15 R SMAD BINDING 4 23 8.065e-07 4.683e-05
16 TRANSCRIPTION FACTOR BINDING 11 524 7.619e-07 4.683e-05
17 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 6 104 1.004e-06 5.485e-05
18 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 5 64 1.886e-06 9.736e-05
19 KINASE ACTIVITY 13 842 2.135e-06 0.0001044
20 CORE PROMOTER PROXIMAL REGION DNA BINDING 9 371 2.644e-06 0.000117
21 RECEPTOR BINDING 17 1476 2.56e-06 0.000117
22 KINASE BINDING 11 606 3.124e-06 0.0001295
23 RECEPTOR ACTIVATOR ACTIVITY 4 32 3.205e-06 0.0001295
24 MOLECULAR FUNCTION REGULATOR 16 1353 3.876e-06 0.00015
25 SIGNAL TRANSDUCER ACTIVITY 18 1731 5.119e-06 0.0001789
26 I SMAD BINDING 3 11 5.063e-06 0.0001789
27 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 4 36 5.2e-06 0.0001789
28 PHOSPHATASE REGULATOR ACTIVITY 5 87 8.64e-06 0.0002799
29 ARMADILLO REPEAT DOMAIN BINDING 3 13 8.736e-06 0.0002799
30 RECEPTOR REGULATOR ACTIVITY 4 45 1.287e-05 0.0003858
31 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 13 992 1.265e-05 0.0003858
32 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 1.622e-05 0.0004708
33 ACTIVATING TRANSCRIPTION FACTOR BINDING 4 57 3.316e-05 0.0009335
34 PROTEIN DIMERIZATION ACTIVITY 13 1149 5.873e-05 0.001605
35 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 7 315 6.476e-05 0.001719
36 CHROMATIN BINDING 8 435 7.158e-05 0.001847
37 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 6 226 8.454e-05 0.002123
38 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 13 1199 9.06e-05 0.002215
39 CALMODULIN DEPENDENT PROTEIN KINASE ACTIVITY 3 28 9.669e-05 0.002303
40 RHO GTPASE BINDING 4 78 0.0001139 0.002645
41 DOUBLE STRANDED DNA BINDING 10 764 0.0001459 0.003306
42 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 9 629 0.0001672 0.003698
43 HORMONE RECEPTOR BINDING 5 168 0.0002013 0.004251
44 UBIQUITIN LIKE PROTEIN LIGASE BINDING 6 264 0.0001974 0.004251
45 ANDROGEN RECEPTOR BINDING 3 39 0.0002631 0.005315
46 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 0.0002632 0.005315
47 CALMODULIN BINDING 5 179 0.0002701 0.005339
48 TRANSCRIPTION COACTIVATOR ACTIVITY 6 296 0.0003644 0.007054
49 SEQUENCE SPECIFIC DNA BINDING 11 1037 0.0004097 0.007768
50 PROTEIN HOMODIMERIZATION ACTIVITY 9 722 0.0004615 0.008575
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALOSOME 6 11 3.851e-13 2.249e-10
2 BETA CATENIN DESTRUCTION COMPLEX 6 14 2.485e-12 7.256e-10
3 PHOSPHATASE COMPLEX 7 48 1.627e-10 3.168e-08
4 ENDOCYTIC VESICLE MEMBRANE 9 152 1.285e-09 1.877e-07
5 PROTEIN PHOSPHATASE TYPE 2A COMPLEX 5 20 4.274e-09 4.992e-07
6 CATALYTIC COMPLEX 17 1038 1.724e-08 1.678e-06
7 ENDOCYTIC VESICLE 9 256 1.195e-07 9.968e-06
8 TRANSCRIPTION FACTOR COMPLEX 9 298 4.31e-07 3.146e-05
9 CHROMATIN 10 441 1.283e-06 8.324e-05
10 CHROMOSOME 13 880 3.468e-06 0.0001939
11 TRANSCRIPTIONAL REPRESSOR COMPLEX 5 74 3.889e-06 0.0001939
12 NUCLEAR CHROMATIN 8 291 3.985e-06 0.0001939
13 VESICLE MEMBRANE 10 512 4.853e-06 0.000218
14 CYTOPLASMIC VESICLE PART 10 601 1.957e-05 0.0008163
15 NUCLEAR EUCHROMATIN 3 24 6.029e-05 0.002347
16 PROTEINACEOUS EXTRACELLULAR MATRIX 7 356 0.0001387 0.004318
17 CYTOSKELETAL PART 14 1436 0.0001445 0.004318
18 INTRACELLULAR VESICLE 13 1259 0.0001479 0.004318
19 SYNAPSE 10 754 0.000131 0.004318
20 EUCHROMATIN 3 31 0.0001318 0.004318
21 SCF UBIQUITIN LIGASE COMPLEX 3 34 0.0001742 0.004845
22 PROTEIN KINASE COMPLEX 4 90 0.0001982 0.005262
23 GOLGI LUMEN 4 94 0.0002343 0.00595
24 NUCLEAR CHROMOSOME 8 523 0.0002535 0.006168
25 EXTRACELLULAR MATRIX 7 426 0.0004132 0.009653

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 64 151 2.454e-143 4.418e-141
2 hsa04390_Hippo_signaling_pathway 28 154 4.439e-43 3.995e-41
3 hsa04916_Melanogenesis 24 101 8.478e-40 5.087e-38
4 hsa04114_Oocyte_meiosis 15 114 1.062e-20 4.777e-19
5 hsa04340_Hedgehog_signaling_pathway 11 56 1.939e-17 6.982e-16
6 hsa04520_Adherens_junction 11 73 4.447e-16 1.334e-14
7 hsa04720_Long.term_potentiation 9 70 1.093e-12 2.811e-11
8 hsa04662_B_cell_receptor_signaling_pathway 8 75 9.965e-11 2.242e-09
9 hsa04350_TGF.beta_signaling_pathway 8 85 2.773e-10 5.545e-09
10 hsa04370_VEGF_signaling_pathway 7 76 4.506e-09 8.11e-08
11 hsa04360_Axon_guidance 8 130 8.363e-09 1.368e-07
12 hsa04010_MAPK_signaling_pathway 10 268 1.265e-08 1.898e-07
13 hsa04912_GnRH_signaling_pathway 7 101 3.33e-08 4.611e-07
14 hsa04660_T_cell_receptor_signaling_pathway 7 108 5.305e-08 6.821e-07
15 hsa04020_Calcium_signaling_pathway 8 177 9.318e-08 1.118e-06
16 hsa04971_Gastric_acid_secretion 6 74 1.32e-07 1.485e-06
17 hsa04510_Focal_adhesion 8 200 2.382e-07 2.522e-06
18 hsa04650_Natural_killer_cell_mediated_cytotoxicity 7 136 2.589e-07 2.589e-06
19 hsa04110_Cell_cycle 6 128 3.379e-06 3.042e-05
20 hsa04380_Osteoclast_differentiation 6 128 3.379e-06 3.042e-05
21 hsa03015_mRNA_surveillance_pathway 5 83 6.856e-06 5.877e-05
22 hsa04012_ErbB_signaling_pathway 5 87 8.64e-06 7.069e-05
23 hsa04151_PI3K_AKT_signaling_pathway 8 351 1.563e-05 0.0001223
24 hsa04062_Chemokine_signaling_pathway 6 189 3.129e-05 0.0002346
25 hsa04270_Vascular_smooth_muscle_contraction 5 116 3.493e-05 0.0002515
26 hsa04670_Leukocyte_transendothelial_migration 5 117 3.64e-05 0.000252
27 hsa04710_Circadian_rhythm_._mammal 3 23 5.287e-05 0.0003464
28 hsa04722_Neurotrophin_signaling_pathway 5 127 5.389e-05 0.0003464
29 hsa04530_Tight_junction 5 133 6.713e-05 0.0004167
30 hsa04210_Apoptosis 4 89 0.0001899 0.001139
31 hsa04330_Notch_signaling_pathway 3 47 0.0004583 0.002661
32 hsa04730_Long.term_depression 3 70 0.001468 0.008259
33 hsa04970_Salivary_secretion 3 89 0.002917 0.01591
34 hsa04540_Gap_junction 3 90 0.003011 0.01594
35 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.004283 0.02203
36 hsa04810_Regulation_of_actin_cytoskeleton 4 214 0.004906 0.02453
37 hsa04740_Olfactory_transduction 5 388 0.008005 0.03894
38 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.008746 0.04143
39 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.01005 0.04638
40 hsa04742_Taste_transduction 2 52 0.01206 0.05427
41 hsa04630_Jak.STAT_signaling_pathway 3 155 0.01347 0.05915
42 hsa04115_p53_signaling_pathway 2 69 0.02061 0.08832
43 hsa04976_Bile_secretion 2 71 0.02174 0.09101
44 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.02652 0.1085
45 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.03168 0.1267
46 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.03721 0.1456
47 hsa04014_Ras_signaling_pathway 3 236 0.03994 0.153
48 hsa04972_Pancreatic_secretion 2 101 0.04157 0.1559
49 hsa04910_Insulin_signaling_pathway 2 138 0.07223 0.2653

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-166D19.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1266-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-193a-3p;hsa-miR-20a-5p;hsa-miR-589-3p;hsa-miR-942-5p 10 CCND1 Sponge network -0.244 0.28835 -0.902 1.0E-5 0.253

Quest ID: a93707f693b36ae1281ade69091c2cc8