Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-146b-5p AASS -0.42 0.04574 1.86 0 miRanda -0.17 0.01702 NA
2 hsa-miR-200b-3p ABAT 1.29 0.00027 2.16 0 MirTarget; TargetScan -0.2 0 NA
3 hsa-miR-21-5p ABAT -1.51 0 2.16 0 MirTarget -0.93 0 NA
4 hsa-miR-21-5p ABCA1 -1.51 0 1.1 0 mirMAP -0.29 0 NA
5 hsa-miR-21-5p ABCA10 -1.51 0 1.06 4.0E-5 mirMAP -0.45 0 NA
6 hsa-miR-21-5p ABCD3 -1.51 0 0.9 0 miRNAWalker2 validate -0.38 0 NA
7 hsa-miR-877-5p ABHD2 -1.36 0 1.2 0 mirMAP -0.31 0 NA
8 hsa-miR-21-5p ACAT1 -1.51 0 1.62 0 miRNAWalker2 validate -0.62 0 NA
9 hsa-miR-21-5p ACBD5 -1.51 0 0.75 0 miRNAWalker2 validate; miRNATAP -0.33 0 NA
10 hsa-miR-146b-5p ACO1 -0.42 0.04574 0.9 0 miRanda -0.12 9.0E-5 NA
11 hsa-miR-200b-3p ACVR1C 1.29 0.00027 2.2 0 TargetScan -0.18 0 NA
12 hsa-miR-21-5p ACVR2A -1.51 0 0.55 0 miRNATAP -0.17 0 NA
13 hsa-miR-146b-5p ADCY1 -0.42 0.04574 2.7 0 mirMAP -0.41 0 NA
14 hsa-miR-146b-5p AFAP1L2 -0.42 0.04574 0.55 0.00077 miRanda; miRNATAP -0.13 0.00063 NA
15 hsa-miR-877-5p AFF1 -1.36 0 0.71 0 miRNAWalker2 validate -0.16 0 NA
16 hsa-miR-877-5p AGL -1.36 0 1.74 0 MirTarget -0.34 0 NA
17 hsa-miR-21-5p AIM1 -1.51 0 1.46 0 miRNAWalker2 validate -0.35 0 NA
18 hsa-miR-146b-5p AKAP13 -0.42 0.04574 0.32 0.00142 miRanda -0.12 0 NA
19 hsa-miR-21-5p AKAP6 -1.51 0 0.97 0 MirTarget -0.54 0 NA
20 hsa-miR-146b-5p AKAP9 -0.42 0.04574 0.79 0 miRanda -0.18 0 NA
21 hsa-miR-21-5p AKAP9 -1.51 0 0.79 0 miRNAWalker2 validate -0.29 0 NA
22 hsa-miR-21-5p AKIRIN1 -1.51 0 0.73 0 miRNATAP -0.13 0.00038 NA
23 hsa-miR-150-5p AKR1C2 1.15 0 -0.25 0.39842 mirMAP -0.19 0.00177 NA
24 hsa-miR-21-5p AKT2 -1.51 0 0.34 1.0E-5 miRNAWalker2 validate -0.25 0 NA
25 hsa-miR-146b-5p AKT3 -0.42 0.04574 0.66 0.00047 miRNAWalker2 validate -0.16 0.00026 NA
26 hsa-miR-877-5p AMOTL1 -1.36 0 0.53 0.02603 mirMAP -0.14 0.01575 NA
27 hsa-miR-146b-5p AMOTL2 -0.42 0.04574 1.29 0 miRanda -0.14 0.0002 NA
28 hsa-miR-146b-5p ANGPTL1 -0.42 0.04574 2.91 0 miRanda -0.4 0 NA
29 hsa-miR-200b-3p ANGPTL3 1.29 0.00027 1.81 0 TargetScan -0.13 0.00277 NA
30 hsa-miR-877-5p ANKFY1 -1.36 0 0.58 0 MirTarget -0.13 0 NA
31 hsa-miR-21-5p ANKRD28 -1.51 0 0.36 1.0E-5 miRNAWalker2 validate -0.17 0 NA
32 hsa-miR-21-5p ANKRD46 -1.51 0 0.78 0 miRNAWalker2 validate; miRTarBase -0.41 0 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC
33 hsa-miR-21-5p ANO3 -1.51 0 2.3 0 mirMAP -0.98 0 NA
34 hsa-miR-200a-3p ANO5 1.5 3.0E-5 1.28 0.00055 mirMAP -0.12 0.01856 NA
35 hsa-miR-200b-3p ANO5 1.29 0.00027 1.28 0.00055 TargetScan -0.13 0.00908 NA
36 hsa-miR-146b-5p ANXA3 -0.42 0.04574 2.62 0 miRanda -0.29 0.00067 NA
37 hsa-miR-146b-5p AOC3 -0.42 0.04574 0.85 0 miRanda -0.1 0.00112 NA
38 hsa-miR-21-5p AP1AR -1.51 0 0.61 0 MirTarget; miRNATAP -0.25 0 NA
39 hsa-miR-652-3p AP1G1 -0.14 0.3917 0.48 0 miRNAWalker2 validate -0.1 3.0E-5 NA
40 hsa-miR-877-5p AP3S2 -1.36 0 0.33 4.0E-5 mirMAP -0.14 0 NA
41 hsa-miR-21-5p APC -1.51 0 0.18 0.06792 miRNAWalker2 validate -0.17 0 23773491; 24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry
42 hsa-miR-21-5p APOLD1 -1.51 0 -0.45 0.00929 miRNAWalker2 validate -0.18 0.00545 NA
43 hsa-miR-146b-5p AQP1 -0.42 0.04574 0.67 0.0031 miRanda -0.18 0.00079 NA
44 hsa-miR-200a-3p AR 1.5 3.0E-5 2.66 0 mirMAP -0.32 0 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells
45 hsa-miR-877-5p AR -1.36 0 2.66 0 MirTarget -0.92 0 NA
46 hsa-miR-21-5p ARHGAP21 -1.51 0 0.09 0.37274 miRNAWalker2 validate -0.11 0.00286 NA
47 hsa-miR-21-5p ARHGAP24 -1.51 0 0.99 0 MirTarget; miRNATAP -0.36 0 NA
48 hsa-miR-21-5p ARHGAP32 -1.51 0 0.2 0.09921 MirTarget -0.29 0 NA
49 hsa-miR-146b-5p ARHGAP6 -0.42 0.04574 -0.22 0.19399 PITA; miRanda -0.11 0.00647 NA
50 hsa-miR-21-5p ARHGEF12 -1.51 0 0.86 0 miRNAWalker2 validate; MirTarget -0.26 0 NA
51 hsa-miR-146b-5p ARHGEF4 -0.42 0.04574 1.69 3.0E-5 miRanda -0.27 0.0043 NA
52 hsa-miR-877-5p ARHGEF6 -1.36 0 0.58 0.00012 miRNAWalker2 validate -0.1 0.0076 NA
53 hsa-miR-21-5p ARID4A -1.51 0 0.9 0 miRNAWalker2 validate -0.43 0 NA
54 hsa-miR-200b-3p ARPP21 1.29 0.00027 2.21 0 MirTarget -0.14 0.01222 NA
55 hsa-miR-21-5p ART4 -1.51 0 1.74 0 mirMAP -0.48 1.0E-5 NA
56 hsa-miR-21-5p ASPN -1.51 0 1.64 0 MirTarget; miRNATAP -0.2 0.04902 NA
57 hsa-miR-877-5p ASTN1 -1.36 0 1.44 0 MirTarget -0.26 0.00014 NA
58 hsa-miR-146b-5p ASXL2 -0.42 0.04574 0.29 0.18051 miRanda -0.12 0.01657 NA
59 hsa-miR-200b-3p ASXL3 1.29 0.00027 2.69 0 TargetScan -0.17 0.00117 NA
60 hsa-miR-21-5p ATAD2B -1.51 0 0.06 0.4791 miRNAWalker2 validate -0.14 3.0E-5 NA
61 hsa-miR-877-5p ATE1 -1.36 0 0.6 0.0009 MirTarget -0.14 0.00256 NA
62 hsa-miR-21-5p ATF2 -1.51 0 0.24 0.15619 miRNAWalker2 validate -0.18 0.00336 NA
63 hsa-miR-21-5p ATMIN -1.51 0 0.37 0 miRNAWalker2 validate -0.12 0 NA
64 hsa-miR-146b-5p ATP10B -0.42 0.04574 0.24 0.56639 miRanda; miRNATAP -0.27 0.00487 NA
65 hsa-miR-21-5p ATP11B -1.51 0 0.35 0.00133 miRNAWalker2 validate -0.16 4.0E-5 NA
66 hsa-miR-200b-3p ATP11C 1.29 0.00027 1.6 0 MirTarget; TargetScan -0.15 0 NA
67 hsa-miR-21-5p ATP2B2 -1.51 0 0.4 0.15518 mirMAP -0.24 0.01837 NA
68 hsa-miR-21-5p ATRN -1.51 0 -0.12 0.34173 miRNATAP -0.17 0.00015 NA
69 hsa-miR-21-5p ATRNL1 -1.51 0 2.28 0 MirTarget -0.65 8.0E-5 NA
70 hsa-miR-21-5p ATRX -1.51 0 0.07 0.48759 miRNAWalker2 validate -0.1 0.00335 NA
71 hsa-miR-21-5p ATXN3 -1.51 0 0.29 0.00037 mirMAP -0.22 0 NA
72 hsa-miR-21-5p AUTS2 -1.51 0 1.2 0 miRNAWalker2 validate -0.85 0 NA
73 hsa-miR-146b-5p B3GNT5 -0.42 0.04574 -0.79 0.0009 miRanda -0.15 0.00816 NA
74 hsa-miR-21-5p BACE1 -1.51 0 0.45 0 mirMAP -0.29 0 NA
75 hsa-miR-200b-3p BAGE 1.29 0.00027 -1.25 0.00088 MirTarget -0.23 1.0E-5 NA
76 hsa-miR-146b-5p BAZ2B -0.42 0.04574 0.61 0 miRanda -0.1 0.00011 NA
77 hsa-miR-146b-5p BCAT2 -0.42 0.04574 -1.58 0 miRNATAP -0.11 0.00603 NA
78 hsa-miR-21-5p BCL6 -1.51 0 0.38 0.00305 miRNAWalker2 validate -0.19 6.0E-5 NA
79 hsa-miR-21-5p BDH2 -1.51 0 1.59 0 miRNAWalker2 validate -0.57 0 NA
80 hsa-miR-146b-5p BHLHB9 -0.42 0.04574 -0.02 0.89414 miRanda -0.14 8.0E-5 NA
81 hsa-miR-877-5p BIVM -1.36 0 0.29 0.00612 miRNATAP -0.11 1.0E-5 NA
82 hsa-miR-21-5p BMP2K -1.51 0 0.82 0 mirMAP -0.12 0.00963 NA
83 hsa-miR-146b-5p BMP8A -0.42 0.04574 -1.39 0 miRanda -0.12 0.02024 NA
84 hsa-miR-21-5p BMPR2 -1.51 0 0.74 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.28 0 NA
85 hsa-miR-877-5p BMPR2 -1.36 0 0.74 0 MirTarget -0.15 0 NA
86 hsa-miR-21-5p BRD1 -1.51 0 0.22 0.01173 MirTarget -0.1 0.0018 NA
87 hsa-miR-877-5p BTD -1.36 0 0.71 0 MirTarget -0.24 0 NA
88 hsa-miR-21-5p C16orf52 -1.51 0 0.5 0 miRNATAP -0.29 0 NA
89 hsa-miR-146b-5p C1orf21 -0.42 0.04574 0.75 0.00045 mirMAP -0.1 0.03512 NA
90 hsa-miR-200a-3p C1orf21 1.5 3.0E-5 0.75 0.00045 miRNATAP -0.12 4.0E-5 NA
91 hsa-miR-877-5p C1orf21 -1.36 0 0.75 0.00045 mirMAP -0.32 0 NA
92 hsa-miR-21-5p C1orf226 -1.51 0 -0.29 0.07217 mirMAP -0.13 0.03584 NA
93 hsa-miR-150-5p C3orf18 1.15 0 -0.57 0.00014 miRNATAP -0.13 1.0E-5 NA
94 hsa-miR-150-5p C6orf223 1.15 0 -0.67 0.18925 mirMAP -0.26 0.01153 NA
95 hsa-miR-200a-3p CADM1 1.5 3.0E-5 0.03 0.88629 MirTarget -0.12 0 NA
96 hsa-miR-200b-3p CADM1 1.29 0.00027 0.03 0.88629 TargetScan -0.13 0 NA
97 hsa-miR-21-5p CADM2 -1.51 0 2.32 0 mirMAP; miRNATAP -0.38 0.00648 NA
98 hsa-miR-146b-5p CALCRL -0.42 0.04574 -0.11 0.54853 miRanda -0.11 0.01138 NA
99 hsa-miR-21-5p CALD1 -1.51 0 0.53 0 miRNAWalker2 validate; MirTarget -0.27 0 NA
100 hsa-miR-146b-5p CAPS -0.42 0.04574 -0.58 0.00027 miRanda -0.11 0.00402 NA
101 hsa-miR-146b-5p CAPS2 -0.42 0.04574 0.81 8.0E-5 miRanda -0.18 0.00014 NA
102 hsa-miR-21-5p CASC4 -1.51 0 0.46 0 miRNATAP -0.14 8.0E-5 NA
103 hsa-miR-146b-5p CASR -0.42 0.04574 3.09 0 miRanda -0.19 0.04519 26178670 miR 135b and miR 146b dependent silencing of calcium sensing receptor expression in colorectal tumors; Inhibition of miR-135b and miR-146b expression led to high CaSR levels and significantly reduced proliferation; In samples of colorectal tumors we observed overexpression of miR-135b and miR-146b and this correlated inversely with CaSR expression miR-135b: r = -0.684 p < 0.001 and miR-146b: r = -0.448 p < 0.001 supporting our in vitro findings; We demonstrate that miR-135b and miR-146b target the CaSR and reduce its expression in colorectal tumors reducing the antiproliferative and prodifferentiating actions of calcium
104 hsa-miR-877-5p CBFA2T3 -1.36 0 2.47 0 miRNATAP -0.29 0 NA
105 hsa-miR-21-5p CCDC121 -1.51 0 -0.09 0.43018 MirTarget -0.21 0 NA
106 hsa-miR-21-5p CCDC152 -1.51 0 1.09 0 mirMAP -0.61 0 NA
107 hsa-miR-146b-5p CCDC85A -0.42 0.04574 -0.74 9.0E-5 miRanda -0.13 0.00257 NA
108 hsa-miR-21-5p CCNG1 -1.51 0 0.05 0.64033 miRNAWalker2 validate -0.13 0.00024 NA
109 hsa-miR-146b-5p CCNJ -0.42 0.04574 0.4 0.0818 PITA; miRanda; miRNATAP -0.13 0.01784 NA
110 hsa-miR-877-5p CD302 -1.36 0 1.76 0 MirTarget -0.3 0 NA
111 hsa-miR-652-3p CD46 -0.14 0.3917 -0.36 0.00059 miRNAWalker2 validate -0.12 0.00015 NA
112 hsa-miR-200a-3p CDC14B 1.5 3.0E-5 1.19 0 mirMAP -0.15 0 NA
113 hsa-miR-150-5p CDCA5 1.15 0 -3.36 0 mirMAP -0.14 0.00793 NA
114 hsa-miR-146b-5p CDH1 -0.42 0.04574 0.93 4.0E-5 miRanda -0.21 6.0E-5 NA
115 hsa-miR-877-5p CDH19 -1.36 0 4.11 0 MirTarget -0.28 0.00793 NA
116 hsa-miR-150-5p CDHR3 1.15 0 -0.83 1.0E-5 mirMAP -0.2 0 NA
117 hsa-miR-146b-5p CDKN1A -0.42 0.04574 0.77 6.0E-5 miRNAWalker2 validate -0.15 0.00059 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis
118 hsa-miR-877-5p CDO1 -1.36 0 1.67 0 MirTarget -0.43 0 NA
119 hsa-miR-146b-5p CDS1 -0.42 0.04574 0.32 0.40167 miRanda; miRNATAP -0.22 0.01361 NA
120 hsa-miR-200b-3p CECR2 1.29 0.00027 0.78 0.01282 TargetScan -0.3 0 NA
121 hsa-miR-877-5p CFHR5 -1.36 0 1.75 0.00027 MirTarget -0.64 0 NA
122 hsa-miR-200b-3p CFL2 1.29 0.00027 1.18 0 MirTarget; TargetScan -0.15 0 NA
123 hsa-miR-200b-3p CHN2 1.29 0.00027 0.87 0 MirTarget; TargetScan -0.15 0 NA
124 hsa-miR-21-5p CLCN5 -1.51 0 0.78 0 miRNAWalker2 validate; mirMAP -0.33 0 NA
125 hsa-miR-146b-5p CLDN10 -0.42 0.04574 5.18 0 miRanda -0.26 0.04926 NA
126 hsa-miR-877-5p CLEC14A -1.36 0 -0.26 0.07318 MirTarget -0.17 0 NA
127 hsa-miR-146b-5p CLIC5 -0.42 0.04574 -0.65 0.00496 miRanda -0.15 0.00602 NA
128 hsa-miR-146b-5p CLOCK -0.42 0.04574 0.53 0.00745 mirMAP -0.19 5.0E-5 NA
129 hsa-miR-21-5p CLOCK -1.51 0 0.53 0.00745 miRNAWalker2 validate -0.26 0.00029 NA
130 hsa-miR-652-3p CNN3 -0.14 0.3917 -0 0.99816 miRNAWalker2 validate -0.1 0.00282 NA
131 hsa-miR-146b-5p CNTFR -0.42 0.04574 3.51 0 miRNATAP -0.26 0.03741 NA
132 hsa-miR-21-5p CNTFR -1.51 0 3.51 0 miRNATAP -1.1 0 NA
133 hsa-miR-146b-5p CNTN1 -0.42 0.04574 2.32 0 miRanda -0.23 0.02389 NA
134 hsa-miR-877-5p CNTN3 -1.36 0 3.79 0 MirTarget -0.75 0 NA
135 hsa-miR-21-5p COBLL1 -1.51 0 1.47 0 miRNAWalker2 validate -0.8 0 NA
136 hsa-miR-146b-5p COL6A3 -0.42 0.04574 -0.17 0.43229 miRanda -0.13 0.00943 NA
137 hsa-miR-146b-5p COQ9 -0.42 0.04574 0.62 0 miRanda -0.1 0.00021 NA
138 hsa-miR-21-5p CPEB3 -1.51 0 2.74 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.98 0 NA
139 hsa-miR-200a-3p CPLX2 1.5 3.0E-5 -5.16 0 mirMAP -0.38 0.00019 NA
140 hsa-miR-146b-5p CRB3 -0.42 0.04574 0.07 0.72072 PITA; miRanda -0.14 0.00125 NA
141 hsa-miR-21-5p CREBL2 -1.51 0 0.86 0 miRNATAP -0.28 0 NA
142 hsa-miR-21-5p CRIM1 -1.51 0 0.43 0.03963 miRNATAP -0.15 0.04655 NA
143 hsa-miR-21-5p CSNK1A1 -1.51 0 0.34 0 miRNAWalker2 validate -0.1 0 NA
144 hsa-miR-146b-5p CTBP2 -0.42 0.04574 0.39 0.02251 miRanda -0.18 1.0E-5 NA
145 hsa-miR-877-5p CTBS -1.36 0 1.15 0 MirTarget -0.25 0 NA
146 hsa-miR-150-5p CTH 1.15 0 2.13 0 MirTarget -0.16 0.01441 NA
147 hsa-miR-146b-5p CTNNA3 -0.42 0.04574 2.94 0 miRanda -0.23 0.00499 NA
148 hsa-miR-877-5p CTTNBP2 -1.36 0 2.02 0 MirTarget -0.42 1.0E-5 NA
149 hsa-miR-146b-5p CYB5D1 -0.42 0.04574 0.74 0 mirMAP -0.1 1.0E-5 NA
150 hsa-miR-21-5p CYBRD1 -1.51 0 1.29 0 miRNAWalker2 validate -0.31 6.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 125 1784 7.966e-10 3.706e-06
2 CARDIOVASCULAR SYSTEM DEVELOPMENT 67 788 8.708e-09 1.351e-05
3 CIRCULATORY SYSTEM DEVELOPMENT 67 788 8.708e-09 1.351e-05
4 INTRACELLULAR SIGNAL TRANSDUCTION 109 1572 2.018e-08 2.102e-05
5 TISSUE DEVELOPMENT 106 1518 2.259e-08 2.102e-05
6 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 129 1977 3.203e-08 2.285e-05
7 NEGATIVE REGULATION OF CELL COMMUNICATION 88 1192 3.438e-08 2.285e-05
8 PROTEIN PHOSPHORYLATION 74 944 4.305e-08 2.504e-05
9 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 29 229 5.841e-08 3.02e-05
10 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 111 1656 8.789e-08 4.09e-05
11 REGULATION OF CELL DEATH 101 1472 1.194e-07 4.848e-05
12 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 61 740 1.25e-07 4.848e-05
13 MUSCLE STRUCTURE DEVELOPMENT 42 432 1.671e-07 5.981e-05
14 NEGATIVE REGULATION OF GENE EXPRESSION 101 1493 2.35e-07 7.812e-05
15 MUSCLE TISSUE DEVELOPMENT 31 275 2.954e-07 9.164e-05
16 NEUROGENESIS 95 1402 5.196e-07 0.0001511
17 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 115 1805 6.85e-07 0.0001875
18 GROWTH 39 410 8.01e-07 0.0002071
19 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 100 1517 8.954e-07 0.0002193
20 REGULATION OF HORMONE LEVELS 43 478 9.929e-07 0.000231
21 MUSCLE ORGAN DEVELOPMENT 30 277 1.072e-06 0.0002376
22 REGULATION OF CELL DIFFERENTIATION 98 1492 1.366e-06 0.000289
23 RESPONSE TO ENDOGENOUS STIMULUS 95 1450 2.248e-06 0.0004265
24 BLOOD VESSEL MORPHOGENESIS 35 364 2.291e-06 0.0004265
25 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 72 1008 2.205e-06 0.0004265
26 POSITIVE REGULATION OF GENE EXPRESSION 109 1733 2.547e-06 0.0004558
27 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 54 689 3.105e-06 0.0005312
28 PHOSPHORYLATION 83 1228 3.196e-06 0.0005312
29 REGULATION OF TRANSFERASE ACTIVITY 68 946 3.45e-06 0.0005448
30 CELL DEVELOPMENT 93 1426 3.513e-06 0.0005448
31 NEGATIVE REGULATION OF PHOSPHORYLATION 38 422 4.119e-06 0.000599
32 LUNG ALVEOLUS DEVELOPMENT 10 41 4.109e-06 0.000599
33 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 105 1672 4.272e-06 0.0006024
34 CELLULAR COMPONENT MORPHOGENESIS 65 900 4.896e-06 0.00067
35 RESPIRATORY SYSTEM DEVELOPMENT 23 197 5.474e-06 0.0007277
36 REGULATION OF DEVELOPMENTAL GROWTH 29 289 7.353e-06 0.0009503
37 TUBE DEVELOPMENT 45 552 7.688e-06 0.0009668
38 REGULATION OF PHOSPHORUS METABOLIC PROCESS 101 1618 8.574e-06 0.00105
39 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 67 957 9.735e-06 0.001161
40 POSITIVE REGULATION OF MOLECULAR FUNCTION 109 1791 1.116e-05 0.001298
41 REGULATION OF KINASE ACTIVITY 57 776 1.165e-05 0.001322
42 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 17 126 1.366e-05 0.001514
43 REGULATION OF CELL PROLIFERATION 94 1496 1.403e-05 0.001518
44 REGULATION OF GTPASE ACTIVITY 51 673 1.472e-05 0.001557
45 ORGAN MORPHOGENESIS 60 841 1.648e-05 0.001667
46 DEVELOPMENTAL GROWTH 31 333 1.635e-05 0.001667
47 HEART DEVELOPMENT 39 466 1.709e-05 0.001692
48 REGULATION OF MAP KINASE ACTIVITY 30 319 1.835e-05 0.001776
49 NEGATIVE REGULATION OF CELL PROLIFERATION 49 643 1.871e-05 0.001776
50 REGULATION OF CELLULAR COMPONENT MOVEMENT 56 771 1.915e-05 0.001782
51 VASCULATURE DEVELOPMENT 39 469 1.976e-05 0.001803
52 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 39 470 2.074e-05 0.001855
53 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 27 278 2.698e-05 0.002368
54 REGULATION OF PROTEIN MODIFICATION PROCESS 103 1710 3.055e-05 0.002632
55 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 16 121 3.132e-05 0.002649
56 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 68 1021 4.097e-05 0.003404
57 EPITHELIUM DEVELOPMENT 64 945 4.236e-05 0.003458
58 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 67 1004 4.399e-05 0.003529
59 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 85 1360 4.505e-05 0.003553
60 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 42 541 4.812e-05 0.003671
61 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 42 541 4.812e-05 0.003671
62 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 36 437 4.965e-05 0.003726
63 CELL JUNCTION ORGANIZATION 20 185 6.662e-05 0.004884
64 ANGIOGENESIS 27 293 6.718e-05 0.004884
65 NEGATIVE REGULATION OF MOLECULAR FUNCTION 70 1079 7.144e-05 0.005114
66 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 11 67 7.422e-05 0.005232
67 GOLGI TO VACUOLE TRANSPORT 7 27 7.717e-05 0.005359
68 ORGAN GROWTH 11 68 8.533e-05 0.005839
69 NEGATIVE REGULATION OF KINASE ACTIVITY 24 250 8.903e-05 0.005939
70 REGULATION OF HYDROLASE ACTIVITY 82 1327 9.062e-05 0.005939
71 REGULATION OF LIPID METABOLIC PROCESS 26 282 9.025e-05 0.005939
72 NEURON DIFFERENTIATION 59 874 9.234e-05 0.005968
73 UROGENITAL SYSTEM DEVELOPMENT 27 299 9.467e-05 0.006034
74 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 16 133 9.973e-05 0.006271
75 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 15 120 0.0001055 0.006542
76 REGULATION OF EPITHELIAL CELL PROLIFERATION 26 285 0.0001073 0.006571
77 POSITIVE REGULATION OF CATALYTIC ACTIVITY 91 1518 0.0001091 0.006595
78 REGULATION OF PEPTIDE SECRETION 21 209 0.0001272 0.00759
79 NEGATIVE REGULATION OF PEPTIDE SECRETION 9 49 0.0001367 0.007952
80 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 72 1142 0.0001356 0.007952
81 REGULATION OF MAPK CASCADE 47 660 0.0001416 0.008074
82 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 12 84 0.0001423 0.008074
83 NEGATIVE REGULATION OF CELL DEATH 58 872 0.0001567 0.008534
84 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 89 1492 0.0001545 0.008534
85 REGULATION OF PROTEIN LOCALIZATION 62 950 0.0001577 0.008534
86 BEHAVIOR 39 516 0.0001555 0.008534
87 NEGATIVE REGULATION OF JUN KINASE ACTIVITY 5 14 0.0001606 0.00859
88 KIDNEY EPITHELIUM DEVELOPMENT 15 125 0.0001675 0.008858
89 CARDIAC MUSCLE TISSUE DEVELOPMENT 16 140 0.0001829 0.009522
90 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 19 184 0.0001842 0.009522
91 NEURON DEVELOPMENT 48 687 0.0001885 0.009637
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 118 1737 1.524e-08 1.416e-05
2 PROTEIN KINASE ACTIVITY 55 640 1.389e-07 6.453e-05
3 KINASE ACTIVITY 66 842 2.411e-07 7.467e-05
4 PROTEIN SERINE THREONINE KINASE ACTIVITY 42 445 3.737e-07 8.678e-05
5 GROWTH FACTOR BINDING 19 123 5.371e-07 9.632e-05
6 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 73 992 6.221e-07 9.632e-05
7 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 82 1199 2.341e-06 0.0003107
8 ACTIN BINDING 36 393 5.007e-06 0.0005815
9 CYTOSKELETAL PROTEIN BINDING 60 819 7.414e-06 0.0007296
10 KINASE BINDING 48 606 8.316e-06 0.0007296
11 TRANSLATION REPRESSOR ACTIVITY 7 20 8.639e-06 0.0007296
12 LIPID BINDING 50 657 1.594e-05 0.001139
13 MACROMOLECULAR COMPLEX BINDING 89 1399 1.519e-05 0.001139
14 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 14 92 1.967e-05 0.001305
15 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 13 81 2.161e-05 0.001338
16 MOLECULAR FUNCTION REGULATOR 84 1353 6.308e-05 0.003447
17 PHOSPHATASE ACTIVITY 26 275 5.95e-05 0.003447
18 RECEPTOR SIGNALING PROTEIN ACTIVITY 19 172 7.515e-05 0.003878
19 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 27 303 0.0001182 0.00553
20 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 19 178 0.0001191 0.00553
21 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 45 629 0.0001761 0.007791
22 RETINOIC ACID BINDING 6 23 0.0002452 0.00949
23 INSULIN RECEPTOR BINDING 7 32 0.000245 0.00949
24 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 10 64 0.0002389 0.00949
25 IDENTICAL PROTEIN BINDING 74 1209 0.0002679 0.009872
26 PDZ DOMAIN BINDING 12 90 0.0002763 0.009872
NumGOOverlapSizeP ValueAdj. P Value
1 PLASMA MEMBRANE REGION 67 929 3.652e-06 0.001066
2 MEMBRANE REGION 78 1134 3.397e-06 0.001066
3 PML BODY 15 97 8.19e-06 0.001594
4 EXCITATORY SYNAPSE 22 197 1.768e-05 0.002581
5 CELL PROJECTION 107 1786 2.635e-05 0.003078
6 CELL JUNCTION 73 1151 0.0001014 0.009873

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04010_MAPK_signaling_pathway 27 268 1.4e-05 0.002521
2 hsa04151_PI3K_AKT_signaling_pathway 31 351 4.512e-05 0.003306
3 hsa04390_Hippo_signaling_pathway 18 154 5.51e-05 0.003306
4 hsa04510_Focal_adhesion 20 200 0.0001947 0.008761
5 hsa04920_Adipocytokine_signaling_pathway 10 68 0.0003963 0.01216
6 hsa04310_Wnt_signaling_pathway 16 151 0.0004341 0.01216
7 hsa00514_Other_types_of_O.glycan_biosynthesis 8 46 0.0004728 0.01216
8 hsa04014_Ras_signaling_pathway 21 236 0.0006619 0.01489
9 hsa04012_ErbB_signaling_pathway 11 87 0.0007756 0.01551
10 hsa04270_Vascular_smooth_muscle_contraction 13 116 0.0008621 0.01552
11 hsa04810_Regulation_of_actin_cytoskeleton 18 214 0.00289 0.04412
12 hsa04320_Dorso.ventral_axis_formation 5 25 0.002941 0.04412
13 hsa00053_Ascorbate_and_aldarate_metabolism 5 26 0.003522 0.04876
14 hsa04910_Insulin_signaling_pathway 13 138 0.004107 0.05281
15 hsa00500_Starch_and_sucrose_metabolism 7 54 0.005959 0.07151
16 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 8 71 0.007941 0.08016
17 hsa04530_Tight_junction 12 133 0.007988 0.08016
18 hsa00140_Steroid_hormone_biosynthesis 7 57 0.008016 0.08016
19 hsa00040_Pentose_and_glucuronate_interconversions 5 32 0.008825 0.0836
20 hsa04520_Adherens_junction 8 73 0.009351 0.08416
21 hsa04971_Gastric_acid_secretion 8 74 0.01012 0.08677
22 hsa04660_T_cell_receptor_signaling_pathway 10 108 0.01244 0.1018
23 hsa04070_Phosphatidylinositol_signaling_system 8 78 0.01369 0.1023
24 hsa04722_Neurotrophin_signaling_pathway 11 127 0.01441 0.1023
25 hsa04664_Fc_epsilon_RI_signaling_pathway 8 79 0.0147 0.1023
26 hsa00830_Retinol_metabolism 7 64 0.01478 0.1023
27 hsa04115_p53_signaling_pathway 7 69 0.02161 0.1389
28 hsa04912_GnRH_signaling_pathway 9 101 0.02161 0.1389
29 hsa04630_Jak.STAT_signaling_pathway 12 155 0.02434 0.1511
30 hsa04960_Aldosterone.regulated_sodium_reabsorption 5 42 0.02679 0.1607
31 hsa00982_Drug_metabolism_._cytochrome_P450 7 73 0.02845 0.1624
32 hsa00860_Porphyrin_and_chlorophyll_metabolism 5 43 0.02933 0.1624
33 hsa04540_Gap_junction 8 90 0.02977 0.1624
34 hsa00650_Butanoate_metabolism 4 30 0.03196 0.1664
35 hsa04662_B_cell_receptor_signaling_pathway 7 75 0.03236 0.1664
36 hsa04370_VEGF_signaling_pathway 7 76 0.03445 0.1722
37 hsa04380_Osteoclast_differentiation 10 128 0.03577 0.174
38 hsa04141_Protein_processing_in_endoplasmic_reticulum 12 168 0.0415 0.1966
39 hsa00510_N.Glycan_biosynthesis 5 49 0.04777 0.2205
40 hsa00072_Synthesis_and_degradation_of_ketone_bodies 2 9 0.04903 0.2207
41 hsa04916_Melanogenesis 8 101 0.05306 0.233
42 hsa04350_TGF.beta_signaling_pathway 7 85 0.05726 0.2454
43 hsa00983_Drug_metabolism_._other_enzymes 5 52 0.05907 0.2473
44 hsa04914_Progesterone.mediated_oocyte_maturation 7 87 0.06335 0.2527
45 hsa04730_Long.term_depression 6 70 0.06446 0.2527
46 hsa04710_Circadian_rhythm_._mammal 3 23 0.06459 0.2527
47 hsa04210_Apoptosis 7 89 0.06982 0.2674
48 hsa04977_Vitamin_digestion_and_absorption 3 24 0.07167 0.2688
49 hsa04360_Axon_guidance 9 130 0.08278 0.298
50 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 3 26 0.08682 0.3064
51 hsa00380_Tryptophan_metabolism 4 42 0.08968 0.3104
52 hsa04114_Oocyte_meiosis 8 114 0.09259 0.3144
53 hsa00280_Valine._leucine_and_isoleucine_degradation 4 44 0.1023 0.3287
54 hsa00310_Lysine_degradation 4 44 0.1023 0.3287
55 hsa04973_Carbohydrate_digestion_and_absorption 4 44 0.1023 0.3287
56 hsa04020_Calcium_signaling_pathway 11 177 0.1068 0.3373
57 hsa04620_Toll.like_receptor_signaling_pathway 7 102 0.121 0.3693
58 hsa04512_ECM.receptor_interaction 6 85 0.1313 0.394
59 hsa00120_Primary_bile_acid_biosynthesis 2 16 0.1359 0.3945
60 hsa00770_Pantothenate_and_CoA_biosynthesis 2 16 0.1359 0.3945
61 hsa00260_Glycine._serine_and_threonine_metabolism 3 32 0.1391 0.3976
62 hsa00360_Phenylalanine_metabolism 2 17 0.15 0.4155
63 hsa00450_Selenocompound_metabolism 2 17 0.15 0.4155
64 hsa04970_Salivary_secretion 6 89 0.1533 0.4157
65 hsa04720_Long.term_potentiation 5 70 0.1547 0.4157
66 hsa04150_mTOR_signaling_pathway 4 52 0.1597 0.4227
67 hsa00630_Glyoxylate_and_dicarboxylate_metabolism 2 18 0.1645 0.4291
68 hsa03022_Basal_transcription_factors 3 37 0.1889 0.4789
69 hsa04666_Fc_gamma_R.mediated_phagocytosis 6 95 0.1889 0.4789
70 hsa04340_Hedgehog_signaling_pathway 4 56 0.192 0.48
71 hsa00562_Inositol_phosphate_metabolism 4 57 0.2004 0.4941
72 hsa04144_Endocytosis 11 203 0.204 0.4962
73 hsa00410_beta.Alanine_metabolism 2 22 0.2241 0.5308
74 hsa00910_Nitrogen_metabolism 2 23 0.2393 0.5523
75 hsa03060_Protein_export 2 23 0.2393 0.5523
76 hsa02010_ABC_transporters 3 44 0.2644 0.6025
77 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 2 26 0.2851 0.6414
78 hsa04330_Notch_signaling_pathway 3 47 0.2979 0.662
79 hsa04610_Complement_and_coagulation_cascades 4 69 0.3073 0.6746
80 hsa00250_Alanine._aspartate_and_glutamate_metabolism 2 32 0.3751 0.7698
81 hsa00640_Propanoate_metabolism 2 32 0.3751 0.7698
82 hsa00330_Arginine_and_proline_metabolism 3 54 0.3763 0.7698
83 hsa04972_Pancreatic_secretion 5 101 0.3912 0.7912
84 hsa04146_Peroxisome 4 79 0.4001 0.8003
85 hsa04974_Protein_digestion_and_absorption 4 81 0.4186 0.8279
86 hsa00270_Cysteine_and_methionine_metabolism 2 36 0.4326 0.8464
87 hsa04514_Cell_adhesion_molecules_.CAMs. 6 136 0.4769 0.894
88 hsa04650_Natural_killer_cell_mediated_cytotoxicity 6 136 0.4769 0.894
89 hsa04640_Hematopoietic_cell_lineage 4 88 0.4818 0.894
90 hsa00350_Tyrosine_metabolism 2 41 0.5002 0.9105
91 hsa04062_Chemokine_signaling_pathway 8 189 0.5031 0.9105
92 hsa00071_Fatty_acid_metabolism 2 43 0.5258 0.9281
93 hsa04142_Lysosome 5 121 0.5479 0.9483
94 hsa04622_RIG.I.like_receptor_signaling_pathway 3 71 0.5546 0.9508
95 hsa04110_Cell_cycle 5 128 0.5982 1
96 hsa00564_Glycerophospholipid_metabolism 3 80 0.6358 1
97 hsa04623_Cytosolic_DNA.sensing_pathway 2 56 0.6696 1
98 hsa04621_NOD.like_receptor_signaling_pathway 2 59 0.6973 1
99 hsa04670_Leukocyte_transendothelial_migration 4 117 0.7045 1
100 hsa03320_PPAR_signaling_pathway 2 70 0.7828 1
101 hsa04976_Bile_secretion 2 71 0.7894 1
102 hsa00230_Purine_metabolism 5 162 0.7917 1
103 hsa04120_Ubiquitin_mediated_proteolysis 4 139 0.8208 1
104 hsa04145_Phagosome 4 156 0.8823 1
105 hsa00240_Pyrimidine_metabolism 2 99 0.9148 1
106 hsa03013_RNA_transport 2 152 0.9866 1
107 hsa04740_Olfactory_transduction 2 388 1 1

Quest ID: aa1b10a29a52fc9dcef89c7dd23571d7