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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-484 ADAM10 -0.69 0 -0.39 0.00177 miRNAWalker2 validate -0.16 0.00158 NA
2 hsa-miR-548b-3p ADAM10 -0.8 0 -0.39 0.00177 PITA -0.12 0.00056 NA
3 hsa-miR-590-3p ADAM10 -0.33 0.00051 -0.39 0.00177 PITA -0.15 0.00559 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 12 114 3.506e-13 8.198e-10
2 PROTEOLYSIS 29 1208 3.524e-13 8.198e-10
3 REGULATION OF CATABOLIC PROCESS 21 731 4.474e-11 6.939e-08
4 POSITIVE REGULATION OF CATABOLIC PROCESS 16 395 8.586e-11 8.944e-08
5 POSITIVE REGULATION OF CELL DEATH 19 605 9.611e-11 8.944e-08
6 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 17 498 2.955e-10 1.964e-07
7 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 23 983 2.704e-10 1.964e-07
8 EPHRIN RECEPTOR SIGNALING PATHWAY 9 85 3.391e-10 1.972e-07
9 PROTEIN MATURATION 13 265 5.708e-10 2.656e-07
10 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 13 263 5.202e-10 2.656e-07
11 POSITIVE REGULATION OF RESPONSE TO STIMULUS 31 1929 1.292e-09 4.625e-07
12 REGULATION OF NOTCH SIGNALING PATHWAY 8 67 1.278e-09 4.625e-07
13 REGULATION OF BINDING 13 283 1.273e-09 4.625e-07
14 REGULATION OF PROTEOLYSIS 19 711 1.433e-09 4.762e-07
15 CELLULAR RESPONSE TO OXYGEN LEVELS 10 143 2.083e-09 6.462e-07
16 POSITIVE REGULATION OF PROTEOLYSIS 14 363 2.697e-09 7.844e-07
17 POSITIVE REGULATION OF CELL COMMUNICATION 27 1532 2.944e-09 8.058e-07
18 RESPONSE TO ABIOTIC STIMULUS 22 1024 3.463e-09 8.951e-07
19 RESPONSE TO OXYGEN LEVELS 13 311 3.982e-09 9.751e-07
20 POSITIVE REGULATION OF MOLECULAR FUNCTION 29 1791 4.463e-09 1.038e-06
21 REGULATION OF CELL DEATH 26 1472 5.989e-09 1.327e-06
22 REGULATION OF PROTEIN CATABOLIC PROCESS 14 393 7.422e-09 1.57e-06
23 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 6 32 9.691e-09 1.961e-06
24 NEUROGENESIS 25 1402 1.049e-08 2.034e-06
25 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 6 34 1.427e-08 2.656e-06
26 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 6 36 2.05e-08 3.669e-06
27 ERROR PRONE TRANSLESION SYNTHESIS 5 19 2.806e-08 4.836e-06
28 ERBB2 SIGNALING PATHWAY 6 39 3.394e-08 5.64e-06
29 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 10 192 3.542e-08 5.683e-06
30 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 17 689 3.771e-08 5.848e-06
31 NEGATIVE REGULATION OF MOLECULAR FUNCTION 21 1079 4.634e-08 6.956e-06
32 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 11 274 1.02e-07 1.483e-05
33 GLYCOGEN BIOSYNTHETIC PROCESS 5 25 1.253e-07 1.714e-05
34 GLUCAN BIOSYNTHETIC PROCESS 5 25 1.253e-07 1.714e-05
35 REGULATION OF NECROTIC CELL DEATH 5 26 1.545e-07 2.054e-05
36 POSITIVE REGULATION OF BINDING 8 127 2.065e-07 2.649e-05
37 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 24 1517 2.106e-07 2.649e-05
38 CATABOLIC PROCESS 26 1773 2.556e-07 3.129e-05
39 CELL DEVELOPMENT 23 1426 2.853e-07 3.404e-05
40 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 25 1672 3.221e-07 3.747e-05
41 CELLULAR GLUCAN METABOLIC PROCESS 6 58 3.906e-07 4.227e-05
42 GLUCAN METABOLIC PROCESS 6 58 3.906e-07 4.227e-05
43 CELLULAR RESPONSE TO STRESS 24 1565 3.728e-07 4.227e-05
44 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 7 96 4.558e-07 4.714e-05
45 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 5 32 4.621e-07 4.714e-05
46 REGULATION OF RESPONSE TO STRESS 23 1468 4.762e-07 4.714e-05
47 CELL CYCLE CHECKPOINT 9 194 4.723e-07 4.714e-05
48 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 23 1492 6.326e-07 6.132e-05
49 NOTCH RECEPTOR PROCESSING 4 16 9.429e-07 8.536e-05
50 CELL CELL SIGNALING 16 767 9.414e-07 8.536e-05
51 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 6 67 9.296e-07 8.536e-05
52 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 9 211 9.54e-07 8.536e-05
53 VIRION ASSEMBLY 5 37 9.81e-07 8.612e-05
54 NEGATIVE REGULATION OF CELL DEATH 17 872 1.05e-06 9.043e-05
55 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1087 1.151e-06 9.736e-05
56 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 8 162 1.322e-06 0.0001098
57 ENERGY RESERVE METABOLIC PROCESS 6 72 1.427e-06 0.0001165
58 TRANSLESION SYNTHESIS 5 41 1.661e-06 0.0001324
59 DNA SYNTHESIS INVOLVED IN DNA REPAIR 6 74 1.679e-06 0.0001324
60 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 14 616 1.797e-06 0.0001394
61 POLYSACCHARIDE BIOSYNTHETIC PROCESS 5 42 1.878e-06 0.0001432
62 ERROR FREE TRANSLESION SYNTHESIS 4 19 1.985e-06 0.000149
63 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 18 1021 2.041e-06 0.0001508
64 IMMUNE SYSTEM PROCESS 26 1984 2.19e-06 0.0001568
65 CARBOHYDRATE BIOSYNTHETIC PROCESS 7 121 2.186e-06 0.0001568
66 REGULATION OF CELL ADHESION 14 629 2.293e-06 0.0001616
67 NEGATIVE REGULATION OF GENE EXPRESSION 22 1493 2.472e-06 0.0001643
68 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 236 2.408e-06 0.0001643
69 NEGATIVE REGULATION OF TRANSPORT 12 458 2.465e-06 0.0001643
70 ERBB SIGNALING PATHWAY 6 79 2.47e-06 0.0001643
71 POLYSACCHARIDE METABOLIC PROCESS 6 80 2.659e-06 0.0001743
72 RESPONSE TO TOXIC SUBSTANCE 9 241 2.86e-06 0.0001835
73 REGULATION OF CELL DEVELOPMENT 16 836 2.879e-06 0.0001835
74 POSITIVE REGULATION OF CATALYTIC ACTIVITY 22 1518 3.243e-06 0.0002039
75 REGULATION OF ERBB SIGNALING PATHWAY 6 83 3.301e-06 0.0002048
76 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 4 22 3.705e-06 0.0002239
77 NUCLEOTIDE EXCISION REPAIR DNA DUPLEX UNWINDING 4 22 3.705e-06 0.0002239
78 POSITIVE REGULATION OF KINASE ACTIVITY 12 482 4.161e-06 0.0002451
79 REGULATION OF NEURON DEATH 9 252 4.116e-06 0.0002451
80 NUCLEOTIDE EXCISION REPAIR DNA DAMAGE RECOGNITION 4 23 4.468e-06 0.0002599
81 CELLULAR CARBOHYDRATE BIOSYNTHETIC PROCESS 5 51 5.008e-06 0.0002877
82 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 4 24 5.342e-06 0.0003031
83 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 7 139 5.498e-06 0.0003045
84 MITOTIC CELL CYCLE CHECKPOINT 7 139 5.498e-06 0.0003045
85 INTRACELLULAR SIGNAL TRANSDUCTION 22 1572 5.706e-06 0.0003124
86 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 684 6.021e-06 0.0003257
87 REGULATION OF DNA BINDING 6 93 6.409e-06 0.0003428
88 CELL DEATH 17 1001 6.713e-06 0.000349
89 POSTREPLICATION REPAIR 5 54 6.664e-06 0.000349
90 EMBRYO DEVELOPMENT 16 894 6.751e-06 0.000349
91 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1004 6.983e-06 0.0003571
92 SYNAPTIC SIGNALING 11 424 7.314e-06 0.0003699
93 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 20 1360 8.01e-06 0.0004008
94 NEGATIVE REGULATION OF CELL DIFFERENTIATION 13 609 8.533e-06 0.0004224
95 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 13 616 9.64e-06 0.0004722
96 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 1.014e-05 0.0004864
97 NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY 4 28 1.014e-05 0.0004864
98 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 8 217 1.15e-05 0.0005459
99 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 4 29 1.172e-05 0.0005507
100 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 15 829 1.191e-05 0.000554
101 SOMITOGENESIS 5 62 1.322e-05 0.0006085
102 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 30 1.347e-05 0.0006085
103 GENERATION OF PRECURSOR METABOLITES AND ENERGY 9 292 1.347e-05 0.0006085
104 REGULATION OF TRANSFERASE ACTIVITY 16 946 1.367e-05 0.0006114
105 NEURON PROJECTION DEVELOPMENT 12 545 1.434e-05 0.0006354
106 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 162 1.498e-05 0.0006577
107 REGULATION OF CELL CYCLE ARREST 6 108 1.517e-05 0.0006595
108 PROTEIN LOCALIZATION TO MEMBRANE 10 376 1.577e-05 0.0006796
109 NEGATIVE REGULATION OF CELL COMMUNICATION 18 1192 1.725e-05 0.0007366
110 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 32 1.754e-05 0.000742
111 NEGATIVE REGULATION OF CELL DEVELOPMENT 9 303 1.805e-05 0.0007434
112 RESPONSE TO EXTERNAL STIMULUS 23 1821 1.798e-05 0.0007434
113 REGULATION OF TYPE I INTERFERON PRODUCTION 6 111 1.774e-05 0.0007434
114 REGULATION OF PROTEIN BINDING 7 168 1.896e-05 0.0007739
115 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 4 33 1.989e-05 0.0008046
116 RESPONSE TO ENDOGENOUS STIMULUS 20 1450 2.045e-05 0.0008203
117 CARBOHYDRATE METABOLIC PROCESS 13 662 2.063e-05 0.0008203
118 NEGATIVE REGULATION OF NEURON DEATH 7 171 2.125e-05 0.0008381
119 CELL ACTIVATION 12 568 2.157e-05 0.0008382
120 REGULATION OF WNT SIGNALING PATHWAY 9 310 2.162e-05 0.0008382
121 NEURON DIFFERENTIATION 15 874 2.213e-05 0.0008509
122 REGULATION OF CELLULAR COMPONENT MOVEMENT 14 771 2.307e-05 0.0008798
123 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 3 12 2.431e-05 0.0009121
124 CELL PROLIFERATION 13 672 2.412e-05 0.0009121
125 REGULATION OF KINASE ACTIVITY 14 776 2.477e-05 0.0009181
126 NEURON APOPTOTIC PROCESS 4 35 2.526e-05 0.0009181
127 MEMBRANE PROTEIN PROTEOLYSIS 4 35 2.526e-05 0.0009181
128 REGULATION OF ORGAN MORPHOGENESIS 8 242 2.523e-05 0.0009181
129 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN CELL CELL SIGNALING 5 71 2.569e-05 0.0009266
130 CELL MATRIX ADHESION 6 119 2.634e-05 0.0009356
131 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 6 119 2.634e-05 0.0009356
132 REGULATION OF MAP KINASE ACTIVITY 9 319 2.707e-05 0.0009541
133 REGULATION OF CELL CYCLE PHASE TRANSITION 9 321 2.842e-05 0.000987
134 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 4 36 2.831e-05 0.000987
135 DNA BIOSYNTHETIC PROCESS 6 121 2.894e-05 0.0009976
136 POSITIVE REGULATION OF PROTEIN BINDING 5 73 2.941e-05 0.0009988
137 G1 DNA DAMAGE CHECKPOINT 5 73 2.941e-05 0.0009988
138 OXIDATION REDUCTION PROCESS 15 898 3.028e-05 0.001021
139 REGULATION OF CELL DIFFERENTIATION 20 1492 3.081e-05 0.001031
140 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 3 13 3.149e-05 0.001046
141 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 14 801 3.506e-05 0.001157
142 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 6 127 3.802e-05 0.001237
143 NEGATIVE REGULATION OF ION TRANSPORT 6 127 3.802e-05 0.001237
144 RESPONSE TO ORGANIC CYCLIC COMPOUND 15 917 3.851e-05 0.001244
145 NEGATIVE REGULATION OF ENDOCYTOSIS 4 39 3.908e-05 0.001246
146 NUCLEOTIDE EXCISION REPAIR DNA INCISION 4 39 3.908e-05 0.001246
147 CELLULAR RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 14 3.993e-05 0.001247
148 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 3.974e-05 0.001247
149 BIOLOGICAL ADHESION 16 1032 3.945e-05 0.001247
150 SOMITE DEVELOPMENT 5 78 4.054e-05 0.001258
151 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 16 1036 4.132e-05 0.001264
152 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 16 1036 4.132e-05 0.001264
153 MACROMOLECULAR COMPLEX ASSEMBLY 19 1398 4.184e-05 0.001264
154 MESENCHYME DEVELOPMENT 7 190 4.173e-05 0.001264
155 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 21 1656 4.264e-05 0.00128
156 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 5 79 4.311e-05 0.001282
157 NEGATIVE REGULATION OF TYPE I INTERFERON PRODUCTION 4 40 4.326e-05 0.001282
158 REGULATION OF NEURON APOPTOTIC PROCESS 7 192 4.46e-05 0.001313
159 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 22 1805 4.913e-05 0.00142
160 DNA GEOMETRIC CHANGE 5 81 4.864e-05 0.00142
161 PROTEIN LOCALIZATION 22 1805 4.913e-05 0.00142
162 JNK CASCADE 5 82 5.159e-05 0.001482
163 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 7 197 5.249e-05 0.001498
164 ESTABLISHMENT OF PROTEIN LOCALIZATION 19 1423 5.32e-05 0.001509
165 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 7 199 5.595e-05 0.001578
166 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 5.687e-05 0.001594
167 POSITIVE REGULATION OF CELL CYCLE ARREST 5 85 6.131e-05 0.001708
168 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 4 44 6.331e-05 0.001743
169 INTERSTRAND CROSS LINK REPAIR 4 44 6.331e-05 0.001743
170 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 740 6.496e-05 0.001778
171 CELLULAR CATABOLIC PROCESS 18 1322 6.728e-05 0.001831
172 REGULATION OF PROTEIN MODIFICATION PROCESS 21 1710 6.794e-05 0.001838
173 FC EPSILON RECEPTOR SIGNALING PATHWAY 6 142 7.095e-05 0.001908
174 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 3 17 7.38e-05 0.001962
175 MATURE B CELL DIFFERENTIATION 3 17 7.38e-05 0.001962
176 B CELL DIFFERENTIATION 5 89 7.639e-05 0.001993
177 SEGMENTATION 5 89 7.639e-05 0.001993
178 CELLULAR CARBOHYDRATE METABOLIC PROCESS 6 144 7.667e-05 0.001993
179 LYMPHOCYTE DIFFERENTIATION 7 209 7.618e-05 0.001993
180 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 6 146 8.275e-05 0.002116
181 DNA INTEGRITY CHECKPOINT 6 146 8.275e-05 0.002116
182 NEURON DEATH 4 47 8.225e-05 0.002116
183 IMMUNE RESPONSE 16 1100 8.408e-05 0.002138
184 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 11 554 8.473e-05 0.002143
185 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 6 147 8.593e-05 0.002161
186 REGULATION OF CELL MATURATION 3 18 8.825e-05 0.002196
187 LABYRINTHINE LAYER BLOOD VESSEL DEVELOPMENT 3 18 8.825e-05 0.002196
188 POSITIVE REGULATION OF WOUND HEALING 4 48 8.939e-05 0.002212
189 LEUKOCYTE DIFFERENTIATION 8 292 9.472e-05 0.002284
190 DEFENSE RESPONSE 17 1231 9.294e-05 0.002284
191 MULTICELLULAR ORGANISM METABOLIC PROCESS 5 93 9.419e-05 0.002284
192 INTERSPECIES INTERACTION BETWEEN ORGANISMS 12 662 9.443e-05 0.002284
193 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 12 662 9.443e-05 0.002284
194 REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1618 9.586e-05 0.002299
195 REGULATION OF CYTOKINE PRODUCTION 11 563 9.772e-05 0.00232
196 RESPONSE TO WOUNDING 11 563 9.772e-05 0.00232
197 REGULATION OF MITOTIC CELL CYCLE 10 468 9.959e-05 0.002352
198 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 6 152 0.0001033 0.002416
199 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 470 0.0001031 0.002416
200 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 4 50 0.000105 0.002443
201 PEPTIDE METABOLIC PROCESS 11 571 0.0001107 0.002562
202 NEGATIVE REGULATION OF CELL ADHESION 7 223 0.0001142 0.00263
203 SINGLE ORGANISM CELLULAR LOCALIZATION 14 898 0.0001192 0.002732
204 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 98 0.0001207 0.00274
205 MEMBRANE ORGANIZATION 14 899 0.0001206 0.00274
206 PROTEIN CATABOLIC PROCESS 11 579 0.000125 0.002797
207 CELL PROJECTION ORGANIZATION 14 902 0.0001249 0.002797
208 TISSUE DEVELOPMENT 19 1518 0.0001256 0.002797
209 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 21 1784 0.0001243 0.002797
210 MITOTIC DNA INTEGRITY CHECKPOINT 5 100 0.0001328 0.002943
211 NEURON DEVELOPMENT 12 687 0.0001337 0.002949
212 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 7 229 0.0001346 0.002955
213 ORGANONITROGEN COMPOUND METABOLIC PROCESS 21 1796 0.0001365 0.002983
214 REGULATION OF CELLULAR RESPONSE TO STRESS 12 691 0.0001412 0.003069
215 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 16 1152 0.0001437 0.00311
216 REGULATION OF ION TRANSPORT 11 592 0.0001518 0.00327
217 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 103 0.0001526 0.003273
218 CELL SUBSTRATE ADHESION 6 164 0.0001567 0.003344
219 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 0.0001642 0.003442
220 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 14 926 0.0001642 0.003442
221 NEURON NEURON SYNAPTIC TRANSMISSION 4 56 0.0001637 0.003442
222 MACROMOLECULE CATABOLIC PROCESS 14 926 0.0001642 0.003442
223 CEREBRAL CORTEX DEVELOPMENT 5 105 0.0001671 0.003486
224 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 0.0001747 0.003628
225 POSITIVE REGULATION OF TRANSPORT 14 936 0.0001835 0.003795
226 REGULATION OF NUCLEASE ACTIVITY 3 23 0.0001882 0.003874
227 LEUKOCYTE ACTIVATION 9 414 0.0001982 0.004028
228 REGULATION OF METAL ION TRANSPORT 8 325 0.0001975 0.004028
229 ENDOCYTOSIS 10 509 0.0001971 0.004028
230 PROTEIN PHOSPHORYLATION 14 944 0.0002004 0.004054
231 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 5 110 0.0002077 0.004184
232 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 513 0.0002099 0.00421
233 POSITIVE REGULATION OF CELL CYCLE PROCESS 7 247 0.0002143 0.004226
234 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 3 24 0.0002143 0.004226
235 PATTERN SPECIFICATION PROCESS 9 418 0.0002129 0.004226
236 REGULATION OF EXECUTION PHASE OF APOPTOSIS 3 24 0.0002143 0.004226
237 POSITIVE REGULATION OF LOCOMOTION 9 420 0.0002206 0.00433
238 GLIOGENESIS 6 175 0.0002229 0.004357
239 REGULATION OF AUTOPHAGY 7 249 0.0002251 0.004376
240 CELLULAR AMIDE METABOLIC PROCESS 12 727 0.0002257 0.004376
241 POSITIVE REGULATION OF CELL CYCLE 8 332 0.0002281 0.004405
242 NUCLEOTIDE EXCISION REPAIR 5 113 0.0002355 0.004528
243 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 337 0.0002523 0.004832
244 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 6 181 0.0002672 0.005087
245 REGULATION OF DNA METABOLIC PROCESS 8 340 0.0002679 0.005087
246 MUSCLE STRUCTURE DEVELOPMENT 9 432 0.0002715 0.005135
247 SCHWANN CELL DEVELOPMENT 3 26 0.0002733 0.005148
248 LYMPHOCYTE ACTIVATION 8 342 0.0002786 0.005228
249 POSITIVE REGULATION OF DNA METABOLIC PROCESS 6 185 0.0003005 0.005593
250 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 12 750 0.0002998 0.005593
251 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 262 0.0003066 0.005684
252 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 66 0.0003095 0.005685
253 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 13 867 0.0003103 0.005685
254 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 66 0.0003095 0.005685
255 CELLULAR MACROMOLECULE LOCALIZATION 16 1234 0.0003132 0.005714
256 CELLULAR RESPONSE TO EXTERNAL STIMULUS 7 264 0.000321 0.005835
257 POSITIVE REGULATION OF NEURON DEATH 4 67 0.0003279 0.005937
258 DNA METABOLIC PROCESS 12 758 0.00033 0.005952
259 REGULATION OF DEFENSE RESPONSE 12 759 0.000334 0.006
260 PLACENTA BLOOD VESSEL DEVELOPMENT 3 28 0.0003419 0.006096
261 AUDITORY RECEPTOR CELL DIFFERENTIATION 3 28 0.0003419 0.006096
262 MULTI ORGANISM TRANSPORT 4 68 0.0003471 0.006142
263 MULTI ORGANISM LOCALIZATION 4 68 0.0003471 0.006142
264 PROTEASOMAL PROTEIN CATABOLIC PROCESS 7 271 0.0003758 0.006624
265 RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 29 0.00038 0.006673
266 REGULATION OF MAPK CASCADE 11 660 0.0003855 0.006744
267 I KAPPAB KINASE NF KAPPAB SIGNALING 4 70 0.0003879 0.00676
268 REGULATION OF WOUND HEALING 5 126 0.0003898 0.006767
269 DNA CONFORMATION CHANGE 7 273 0.0003928 0.006794
270 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 6 195 0.000398 0.006859
271 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 1135 0.0004028 0.006916
272 REGULATION OF TRANSPORT 20 1804 0.0004095 0.006979
273 REGULATION OF CELL CYCLE PROCESS 10 558 0.000409 0.006979
274 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 8 365 0.0004301 0.007304
275 REGULATION OF IMMUNE SYSTEM PROCESS 17 1403 0.0004379 0.007408
276 REGULATION OF ENDOCYTOSIS 6 199 0.0004433 0.007446
277 CELLULAR COMPONENT MORPHOGENESIS 13 900 0.0004431 0.007446
278 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 0.0004473 0.007487
279 REGULATION OF LIGASE ACTIVITY 5 130 0.0004498 0.007502
280 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 4 73 0.0004554 0.007567
281 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 7 280 0.000457 0.007567
282 HOMEOSTASIS OF NUMBER OF CELLS WITHIN A TISSUE 3 31 0.0004642 0.007632
283 SCHWANN CELL DIFFERENTIATION 3 31 0.0004642 0.007632
284 NEGATIVE REGULATION OF BINDING 5 131 0.0004659 0.007633
285 REGULATION OF LIPID METABOLIC PROCESS 7 282 0.0004768 0.007785
286 B CELL ACTIVATION 5 132 0.0004824 0.007848
287 ACTIVATION OF INNATE IMMUNE RESPONSE 6 204 0.0005054 0.008194
288 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0005104 0.008246
289 MESENCHYMAL CELL DIFFERENTIATION 5 134 0.0005167 0.008318
290 NEURON PROJECTION GUIDANCE 6 205 0.0005186 0.008321
291 POSITIVE REGULATION OF CELL ADHESION 8 376 0.0005232 0.008366
292 FC RECEPTOR SIGNALING PATHWAY 6 206 0.0005321 0.008449
293 EXTRACELLULAR MATRIX DISASSEMBLY 4 76 0.0005308 0.008449
294 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 0.0005345 0.008459
295 REPRODUCTION 16 1297 0.0005421 0.008551
296 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 0.0005458 0.00858
297 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 0.0005516 0.00863
298 GLIAL CELL DIFFERENTIATION 5 136 0.0005527 0.00863
299 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 4 77 0.0005578 0.008651
300 DETOXIFICATION 4 77 0.0005578 0.008651
301 REGULATION OF CELL CELL ADHESION 8 380 0.0005608 0.00867
302 VIRAL LIFE CYCLE 7 290 0.000563 0.008675
303 ACTIVATION OF MAPK ACTIVITY 5 137 0.0005715 0.008776
304 DNA REPAIR 9 480 0.000583 0.008924
305 LYMPHOCYTE COSTIMULATION 4 78 0.0005857 0.008936
306 CELL CYCLE G2 M PHASE TRANSITION 5 138 0.0005907 0.008982
307 REGULATION OF RNA STABILITY 5 139 0.0006104 0.009251
308 POSITIVE REGULATION OF CELL PROLIFERATION 12 814 0.0006233 0.009416
309 NON CANONICAL WNT SIGNALING PATHWAY 5 140 0.0006305 0.009495
310 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 213 0.0006342 0.009519
311 NEGATIVE REGULATION OF CELL CYCLE PROCESS 6 214 0.0006499 0.009723
312 REGULATION OF GLYCOGEN METABOLIC PROCESS 3 35 0.0006664 0.009874
313 HAIR CELL DIFFERENTIATION 3 35 0.0006664 0.009874
314 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 3 35 0.0006664 0.009874
315 POSITIVE REGULATION OF GENE EXPRESSION 19 1733 0.0006712 0.009914
NumGOOverlapSizeP ValueAdj. P Value
1 ENDOPEPTIDASE ACTIVITY 17 448 5.76e-11 5.351e-08
2 PEPTIDASE ACTIVITY 18 663 3.215e-09 1.36e-06
3 METALLOENDOPEPTIDASE ACTIVITY 9 113 4.393e-09 1.36e-06
4 METALLOPEPTIDASE ACTIVITY 9 188 3.624e-07 6.734e-05
5 CELL ADHESION MOLECULE BINDING 9 186 3.311e-07 6.734e-05
6 INTEGRIN BINDING 7 105 8.398e-07 0.00013
7 EPHRIN RECEPTOR BINDING 4 24 5.342e-06 0.0007089
8 SERINE HYDROLASE ACTIVITY 8 242 2.523e-05 0.002313
9 BETA AMYLOID BINDING 4 35 2.526e-05 0.002313
10 ENZYME BINDING 22 1737 2.739e-05 0.002313
11 RECEPTOR BINDING 20 1476 2.641e-05 0.002313
12 PROTEIN DIMERIZATION ACTIVITY 17 1149 3.959e-05 0.003065
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX 16 426 2.606e-10 1.522e-07
2 PROTEINACEOUS EXTRACELLULAR MATRIX 11 356 1.37e-06 0.0004001
3 EXTRACELLULAR SPACE 21 1376 2.534e-06 0.0004932
4 PERINUCLEAR REGION OF CYTOPLASM 13 642 1.494e-05 0.002182

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Notch_signaling_pathway_hsa04330 8 48 7.978e-11 4.149e-09
2 Apoptosis_hsa04210 8 138 3.911e-07 1.017e-05
3 Sphingolipid_signaling_pathway_hsa04071 7 118 1.847e-06 3.202e-05
4 Rap1_signaling_pathway_hsa04015 8 206 7.869e-06 0.0001023
5 Ras_signaling_pathway_hsa04014 8 232 1.864e-05 0.0001939
6 MAPK_signaling_pathway_hsa04010 8 295 0.0001017 0.0008811
7 VEGF_signaling_pathway_hsa04370 4 59 0.0002006 0.00149
8 PI3K_Akt_signaling_pathway_hsa04151 7 352 0.001733 0.01126
9 cAMP_signaling_pathway_hsa04024 5 198 0.002918 0.01551
10 Focal_adhesion_hsa04510 5 199 0.002982 0.01551
11 Autophagy_animal_hsa04140 4 128 0.003637 0.01719
12 Necroptosis_hsa04217 4 164 0.008668 0.03756
13 Apoptosis_multiple_species_hsa04215 2 33 0.01137 0.04547
14 Lysosome_hsa04142 3 123 0.02262 0.084
15 Mitophagy_animal_hsa04137 2 65 0.04049 0.1404
16 Adherens_junction_hsa04520 2 72 0.04868 0.1582
17 ErbB_signaling_pathway_hsa04012 2 85 0.06529 0.1997
18 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.08245 0.2365
19 HIF_1_signaling_pathway_hsa04066 2 100 0.08642 0.2365
20 FoxO_signaling_pathway_hsa04068 2 132 0.1368 0.334
21 Apelin_signaling_pathway_hsa04371 2 137 0.1452 0.334
22 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.1486 0.334
23 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.156 0.334
24 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.1606 0.334
25 Wnt_signaling_pathway_hsa04310 2 146 0.1606 0.334
26 mTOR_signaling_pathway_hsa04150 2 151 0.1692 0.3384
27 Cellular_senescence_hsa04218 2 160 0.185 0.35
28 Jak_STAT_signaling_pathway_hsa04630 2 162 0.1885 0.35
29 Calcium_signaling_pathway_hsa04020 2 182 0.2242 0.4021
30 Endocytosis_hsa04144 2 244 0.3364 0.5466

Quest ID: abca151d58a507dcfe8354eba34056c9