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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-98-5p A2M 1.11 0 -2.68 0 miRNAWalker2 validate -0.55 0 NA
2 hsa-miR-92a-3p ABCA3 2.06 0 -1.39 0.0022 miRNAWalker2 validate -0.3 0.00142 NA
3 hsa-miR-107 ABCA6 1.31 0 -2.84 1.0E-5 miRanda -0.5 0.00122 NA
4 hsa-miR-98-5p ABCC1 1.11 0 -0.22 0.27162 miRNAWalker2 validate -0.14 0.00543 NA
5 hsa-miR-424-3p ABCC2 0.99 0.00036 -1.65 0.00052 MirTarget -0.17 0.04823 NA
6 hsa-miR-130a-3p ABHD2 2.02 0 -0.37 0.12248 mirMAP -0.21 0 NA
7 hsa-miR-107 ABI3BP 1.31 0 -4.28 0 miRanda -1.14 0 NA
8 hsa-miR-92a-3p ABI3BP 2.06 0 -4.28 0 miRNATAP -1.23 0 NA
9 hsa-miR-103a-3p ABL2 1.44 0 -0.32 0.04554 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
10 hsa-miR-92a-3p ABLIM1 2.06 0 -1.72 0 mirMAP -0.21 0.00032 NA
11 hsa-miR-107 ABR 1.31 0 -0.82 1.0E-5 miRanda -0.14 0.00192 NA
12 hsa-miR-107 ACACB 1.31 0 -2.93 0 miRanda -0.55 0 NA
13 hsa-miR-103a-3p ACE 1.44 0 -0.35 0.17613 mirMAP -0.15 0.01726 NA
14 hsa-miR-107 ACO1 1.31 0 -0.65 0.00055 miRanda -0.17 0.00037 NA
15 hsa-miR-130a-3p ACSL1 2.02 0 -0 0.993 MirTarget; miRNATAP -0.17 6.0E-5 NA
16 hsa-miR-1307-3p ACTB 2.76 0 -0.54 0.00046 miRNAWalker2 validate -0.17 0 NA
17 hsa-miR-92a-3p ACTB 2.06 0 -0.54 0.00046 miRNAWalker2 validate -0.18 0 NA
18 hsa-miR-92a-3p ACTC1 2.06 0 -7.19 0 MirTarget -2.49 0 NA
19 hsa-miR-107 ACTG2 1.31 0 -5.39 0 miRanda -1.98 0 NA
20 hsa-miR-107 ACVR1 1.31 0 -0.44 0.01143 miRanda -0.32 0 NA
21 hsa-miR-130a-3p ACVR1 2.02 0 -0.44 0.01143 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.00012 NA
22 hsa-miR-130a-3p ACVR2A 2.02 0 -0.44 0.02646 miRNATAP -0.16 0 NA
23 hsa-miR-98-5p ADA 1.11 0 0.71 0.04475 miRNAWalker2 validate -0.38 1.0E-5 NA
24 hsa-miR-92a-3p ADAM19 2.06 0 -1.06 0.01895 MirTarget; miRNATAP -0.57 0 NA
25 hsa-miR-92a-3p ADAM23 2.06 0 -1.05 0.04992 miRNATAP -0.3 0.00553 NA
26 hsa-miR-107 ADAMTS1 1.31 0 -3.81 0 miRanda -0.64 0 NA
27 hsa-miR-92a-3p ADAMTS1 2.06 0 -3.81 0 miRNAWalker2 validate -0.74 0 NA
28 hsa-miR-107 ADAMTS14 1.31 0 0.61 0.12479 miRanda -0.56 0 NA
29 hsa-miR-339-3p ADAMTS14 1.23 0 0.61 0.12479 MirTarget -0.42 0 NA
30 hsa-miR-17-3p ADAMTS15 2.27 0 -2.81 0 MirTarget; miRNATAP -0.8 0 NA
31 hsa-miR-98-5p ADAMTS15 1.11 0 -2.81 0 MirTarget -1.16 0 NA
32 hsa-miR-107 ADAMTS3 1.31 0 -1.18 0.00448 miRanda -0.36 0.00044 NA
33 hsa-miR-98-5p ADAMTS5 1.11 0 -2.16 0 miRNAWalker2 validate -0.36 1.0E-5 NA
34 hsa-miR-107 ADAMTS6 1.31 0 -0.88 0.01914 miRanda -0.6 0 NA
35 hsa-miR-98-5p ADAMTS8 1.11 0 -4.33 0 MirTarget -0.63 1.0E-5 NA
36 hsa-miR-107 ADAMTS9 1.31 0 -1.79 0 miRanda -0.41 0 NA
37 hsa-miR-107 ADAMTSL1 1.31 0 -2.52 0 miRanda -0.79 0 NA
38 hsa-miR-17-3p ADAMTSL1 2.27 0 -2.52 0 mirMAP -0.72 0 NA
39 hsa-miR-92a-3p ADAMTSL1 2.06 0 -2.52 0 miRNATAP -0.78 0 NA
40 hsa-miR-103a-3p ADAMTSL3 1.44 0 -5.11 0 MirTarget -1.45 0 NA
41 hsa-miR-107 ADAMTSL3 1.31 0 -5.11 0 MirTarget; PITA; miRanda; miRNATAP -1.12 0 NA
42 hsa-miR-92a-3p ADAMTSL3 2.06 0 -5.11 0 MirTarget; miRNATAP -1.24 0 NA
43 hsa-miR-107 ADAP2 1.31 0 0.02 0.93649 miRanda -0.22 0.00141 NA
44 hsa-miR-107 ADARB1 1.31 0 -1.93 0 miRanda -0.61 0 NA
45 hsa-miR-130a-3p ADCY2 2.02 0 -3.87 0 miRNATAP -0.35 0.00023 NA
46 hsa-miR-107 ADCY4 1.31 0 -1.43 0 miRanda -0.42 0 NA
47 hsa-miR-92a-3p ADCY9 2.06 0 -1.5 0 mirMAP -0.45 0 NA
48 hsa-miR-98-5p ADCY9 1.11 0 -1.5 0 miRNAWalker2 validate -0.47 0 NA
49 hsa-miR-103a-3p ADCYAP1 1.44 0 -3.51 0 MirTarget; miRNATAP -0.86 0 NA
50 hsa-miR-107 ADCYAP1 1.31 0 -3.51 0 MirTarget; PITA; miRanda; miRNATAP -0.92 0 NA
51 hsa-miR-107 ADD1 1.31 0 -0.81 0 PITA; miRanda; miRNATAP -0.11 2.0E-5 NA
52 hsa-miR-103a-3p ADD2 1.44 0 -0.72 0.25015 miRNATAP -0.42 0.00536 NA
53 hsa-miR-107 ADRB2 1.31 0 -1.96 1.0E-5 miRanda -0.3 0.00731 NA
54 hsa-miR-98-5p ADRB2 1.11 0 -1.96 1.0E-5 MirTarget -0.57 0 NA
55 hsa-miR-98-5p ADRB3 1.11 0 -5.02 0 MirTarget -1.23 0 NA
56 hsa-miR-107 AFAP1L2 1.31 0 0.06 0.85809 miRanda -0.32 6.0E-5 NA
57 hsa-miR-130a-3p AFF1 2.02 0 -0.53 0.00163 MirTarget -0.14 0 NA
58 hsa-miR-103a-3p AFF2 1.44 0 -1.73 0.00201 mirMAP; miRNATAP -0.49 0.00034 NA
59 hsa-miR-92a-3p AFF2 2.06 0 -1.73 0.00201 mirMAP -0.29 0.0105 NA
60 hsa-miR-92a-3p AFF3 2.06 0 -5 0 MirTarget -1.14 0 NA
61 hsa-miR-92a-3p AFF4 2.06 0 -0.82 0 mirMAP; miRNATAP -0.13 5.0E-5 NA
62 hsa-miR-22-3p AGBL5 1.22 0 -0.1 0.47409 MirTarget; miRNATAP -0.13 0.00076 NA
63 hsa-miR-103a-3p AGFG1 1.44 0 -0.17 0.30925 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
64 hsa-miR-107 AGFG1 1.31 0 -0.17 0.30925 MirTarget; miRanda; miRNATAP -0.13 0.00126 NA
65 hsa-miR-17-3p AGPAT4 2.27 0 -0.79 0.01174 mirMAP -0.2 0.00186 NA
66 hsa-miR-98-5p AGPS 1.11 0 -0.1 0.48101 miRNAWalker2 validate -0.12 0.00052 NA
67 hsa-miR-107 AHNAK 1.31 0 -1.66 0 miRanda -0.51 0 NA
68 hsa-miR-92a-3p AIDA 2.06 0 -0.31 0.01307 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 1.0E-5 NA
69 hsa-miR-130a-3p AKAP1 2.02 0 -0.34 0.0302 miRNATAP -0.13 0 NA
70 hsa-miR-107 AKAP12 1.31 0 -2.95 0 miRanda; miRNATAP -0.32 0.00251 NA
71 hsa-miR-107 AKAP13 1.31 0 -1.15 0 miRanda; miRNATAP -0.32 0 NA
72 hsa-miR-103a-3p AKAP2 1.44 0 -2.51 8.0E-5 MirTarget -1.29 0 NA
73 hsa-miR-107 AKAP2 1.31 0 -2.51 8.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.63 6.0E-5 NA
74 hsa-miR-98-5p AKAP2 1.11 0 -2.51 8.0E-5 miRNAWalker2 validate -0.93 0 NA
75 hsa-miR-107 AKAP6 1.31 0 -3.34 0 miRanda -0.99 0 NA
76 hsa-miR-98-5p AKAP6 1.11 0 -3.34 0 MirTarget -0.88 0 NA
77 hsa-miR-130a-3p AKAP7 2.02 0 -1.26 1.0E-5 miRNATAP -0.16 0.0004 NA
78 hsa-miR-107 AKT3 1.31 0 -1.94 0 PITA; miRanda -0.44 0 NA
79 hsa-miR-17-3p AKT3 2.27 0 -1.94 0 miRNATAP -0.39 0 NA
80 hsa-miR-22-3p AKT3 1.22 0 -1.94 0 miRNATAP -0.36 0.00064 NA
81 hsa-miR-107 ALDH1B1 1.31 0 -1.84 0 miRanda -0.63 0 NA
82 hsa-miR-92a-3p ALDH1L2 2.06 0 -1.12 0.02448 mirMAP -0.68 0 NA
83 hsa-miR-130a-3p ALDH5A1 2.02 0 0.21 0.50454 mirMAP -0.11 0.03507 NA
84 hsa-miR-92a-3p ALDH7A1 2.06 0 -1.69 0.00179 mirMAP -0.45 4.0E-5 NA
85 hsa-miR-22-3p ALMS1 1.22 0 -0.12 0.43567 miRNAWalker2 validate -0.21 0 NA
86 hsa-miR-103a-3p ALPK3 1.44 0 -1.02 0.00049 mirMAP -0.28 9.0E-5 NA
87 hsa-miR-107 ALPK3 1.31 0 -1.02 0.00049 mirMAP -0.18 0.01507 NA
88 hsa-miR-130a-3p ALPK3 2.02 0 -1.02 0.00049 mirMAP -0.32 0 NA
89 hsa-miR-151a-3p ALPK3 1.24 0 -1.02 0.00049 mirMAP -0.15 0.01148 NA
90 hsa-miR-92a-3p ALPK3 2.06 0 -1.02 0.00049 mirMAP; miRNATAP -0.47 0 NA
91 hsa-miR-22-3p AMOT 1.22 0 -1.51 0.00385 MirTarget; miRNATAP -0.43 0.00433 NA
92 hsa-miR-92a-3p AMOTL1 2.06 0 -1.62 0 miRNAWalker2 validate -0.37 0 NA
93 hsa-miR-107 AMPH 1.31 0 -2.2 0 miRanda -0.52 0 NA
94 hsa-miR-22-3p ANGEL2 1.22 0 0.08 0.44411 MirTarget -0.11 0.00019 NA
95 hsa-miR-17-3p ANGPTL1 2.27 0 -4.51 0 MirTarget -1.31 0 NA
96 hsa-miR-92a-3p ANGPTL2 2.06 0 -1.73 0 miRNATAP -0.82 0 NA
97 hsa-miR-107 ANGPTL7 1.31 0 -5.41 0 miRanda -1.36 0 NA
98 hsa-miR-103a-3p ANK1 1.44 0 -0.47 0.3186 miRNATAP -0.4 0.0005 NA
99 hsa-miR-92a-3p ANKH 2.06 0 -0.38 0.21654 miRNAWalker2 validate -0.33 0 NA
100 hsa-miR-130a-3p ANKRD12 2.02 0 -0.64 0.00012 MirTarget; miRNATAP -0.11 7.0E-5 NA
101 hsa-miR-107 ANKRD44 1.31 0 -1.93 0 miRanda -0.46 0 NA
102 hsa-miR-17-3p ANKRD50 2.27 0 -0.88 0.00174 MirTarget; miRNATAP -0.25 1.0E-5 NA
103 hsa-miR-107 ANKRD6 1.31 0 -0.77 0.00185 miRanda -0.12 0.04541 NA
104 hsa-miR-92a-3p ANKS1A 2.06 0 -0.38 0.09203 miRNAWalker2 validate -0.1 0.02755 NA
105 hsa-miR-107 ANTXR1 1.31 0 -0.71 0.0159 miRanda -0.61 0 NA
106 hsa-miR-151a-3p ANTXR1 1.24 0 -0.71 0.0159 mirMAP -0.52 0 NA
107 hsa-miR-107 ANXA1 1.31 0 -1.02 0.01757 miRanda -0.46 1.0E-5 NA
108 hsa-miR-130a-3p ANXA11 2.02 0 -0.43 0.01849 mirMAP -0.15 0 NA
109 hsa-miR-92a-3p ANXA11 2.06 0 -0.43 0.01849 miRNAWalker2 validate -0.17 0 NA
110 hsa-miR-107 AP1S2 1.31 0 -1.31 0 PITA; miRanda -0.38 0 NA
111 hsa-miR-107 AP2A2 1.31 0 -0.29 0.01105 miRanda -0.1 0.00021 NA
112 hsa-miR-22-3p APBB2 1.22 0 -0.59 0.0014 miRNATAP -0.12 0.02803 NA
113 hsa-miR-130a-3p APCDD1 2.02 0 -1.6 0 MirTarget -0.14 0.01198 NA
114 hsa-miR-92a-3p APCDD1L 2.06 0 -2.55 0.0003 mirMAP -1.03 0 NA
115 hsa-miR-92a-3p APOBEC3C 2.06 0 -0.12 0.60493 miRNAWalker2 validate -0.14 0.00234 NA
116 hsa-miR-92a-3p APOLD1 2.06 0 -2.62 0 miRNAWalker2 validate -0.47 0 NA
117 hsa-miR-130a-3p AR 2.02 0 -3.3 0 mirMAP; miRNATAP -0.61 0 NA
118 hsa-miR-22-3p AR 1.22 0 -3.3 0 miRNATAP -0.59 0.00238 26052614 A direct AR regulation of miR-22 miR-29a and miR-17-92 cluster along with their host genes was confirmed; Interestingly endogenous levels of miR-22 and miR-29a were found to be reduced in PCa cells expressing AR
119 hsa-miR-17-3p ARC 2.27 0 -3.23 0 mirMAP -0.28 0.00601 NA
120 hsa-miR-22-3p ARC 1.22 0 -3.23 0 mirMAP -0.44 0.00366 NA
121 hsa-miR-107 ARHGAP1 1.31 0 -0.88 0 miRanda -0.4 0 NA
122 hsa-miR-130a-3p ARHGAP1 2.02 0 -0.88 0 MirTarget; miRNATAP -0.16 0 NA
123 hsa-miR-103a-3p ARHGAP17 1.44 0 -0.16 0.20019 miRNATAP -0.1 0.00064 NA
124 hsa-miR-107 ARHGAP20 1.31 0 -3.52 0 miRanda -1.1 0 NA
125 hsa-miR-107 ARHGAP22 1.31 0 -0.34 0.32887 miRanda -0.38 1.0E-5 NA
126 hsa-miR-107 ARHGAP24 1.31 0 -2.02 0 miRanda -0.63 0 NA
127 hsa-miR-92a-3p ARHGAP24 2.06 0 -2.02 0 MirTarget -0.63 0 NA
128 hsa-miR-130a-3p ARHGAP26 2.02 0 -0.72 0.00357 mirMAP -0.11 0.00418 NA
129 hsa-miR-98-5p ARHGAP26 1.11 0 -0.72 0.00357 mirMAP -0.18 0.00331 NA
130 hsa-miR-92a-3p ARHGAP29 2.06 0 -0.34 0.31665 MirTarget -0.18 0.01043 NA
131 hsa-miR-103a-3p ARHGAP5 1.44 0 -0.63 0.00047 MirTarget -0.1 0.02341 NA
132 hsa-miR-107 ARHGAP6 1.31 0 -3.25 0 PITA; miRanda -0.43 0.00026 NA
133 hsa-miR-130a-3p ARHGEF12 2.02 0 -0.64 4.0E-5 MirTarget; miRNATAP -0.17 0 NA
134 hsa-miR-17-3p ARHGEF12 2.27 0 -0.64 4.0E-5 MirTarget -0.12 0.0001 NA
135 hsa-miR-22-3p ARHGEF12 1.22 0 -0.64 4.0E-5 MirTarget; miRNATAP -0.16 0.00037 NA
136 hsa-miR-92a-3p ARHGEF17 2.06 0 -1.19 0 miRNATAP -0.42 0 NA
137 hsa-miR-22-3p ARID5B 1.22 0 -1.57 0 miRNAWalker2 validate -0.32 0 NA
138 hsa-miR-22-3p ARIH1 1.22 0 -0.41 0.00018 MirTarget -0.13 6.0E-5 NA
139 hsa-miR-92a-3p ARL10 2.06 0 -1.12 0.00198 mirMAP -0.24 0.00107 NA
140 hsa-miR-107 ARL11 1.31 0 0.5 0.13182 miRanda -0.41 0 NA
141 hsa-miR-107 ARL15 1.31 0 -0.61 0.00667 miRanda -0.19 0.0007 NA
142 hsa-miR-103a-3p ARL4C 1.44 0 -0.28 0.33535 miRNAWalker2 validate; MirTarget -0.43 0 NA
143 hsa-miR-107 ARL4C 1.31 0 -0.28 0.33535 MirTarget; miRanda -0.32 1.0E-5 NA
144 hsa-miR-107 ARMCX2 1.31 0 -0.81 0.03093 miRanda; miRNATAP -0.36 8.0E-5 NA
145 hsa-miR-92a-3p ARRB1 2.06 0 -1.05 0.00043 miRNAWalker2 validate -0.33 0 NA
146 hsa-miR-130a-3p ARRDC3 2.02 0 -0.71 0.00062 miRNATAP -0.11 0.00051 NA
147 hsa-miR-92a-3p ARRDC3 2.06 0 -0.71 0.00062 MirTarget; miRNATAP -0.21 0 NA
148 hsa-miR-92a-3p ARRDC4 2.06 0 -1.43 0 MirTarget; miRNATAP -0.38 0 NA
149 hsa-miR-98-5p ARRDC4 1.11 0 -1.43 0 MirTarget -0.25 0.00056 NA
150 hsa-miR-98-5p ARSJ 1.11 0 -1.58 0.00066 miRNAWalker2 validate -1.07 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 297 1672 2.179e-32 1.014e-28
2 REGULATION OF CELL DIFFERENTIATION 268 1492 6.723e-30 1.564e-26
3 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 195 1021 5.798e-25 8.993e-22
4 BIOLOGICAL ADHESION 195 1032 2.24e-24 2.606e-21
5 NEUROGENESIS 240 1402 1.145e-23 1.065e-20
6 CELL DEVELOPMENT 242 1426 2.471e-23 1.916e-20
7 INTRACELLULAR SIGNAL TRANSDUCTION 257 1572 2.03e-22 1.349e-19
8 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 201 1142 2.89e-21 1.494e-18
9 REGULATION OF PHOSPHORUS METABOLIC PROCESS 259 1618 2.771e-21 1.494e-18
10 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 232 1395 3.432e-21 1.597e-18
11 REGULATION OF CELL DEVELOPMENT 161 836 4.604e-21 1.947e-18
12 POSITIVE REGULATION OF MOLECULAR FUNCTION 278 1791 7.031e-21 2.337e-18
13 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 183 1008 6.812e-21 2.337e-18
14 TISSUE DEVELOPMENT 246 1518 6.328e-21 2.337e-18
15 CARDIOVASCULAR SYSTEM DEVELOPMENT 153 788 2.096e-20 6.096e-18
16 CIRCULATORY SYSTEM DEVELOPMENT 153 788 2.096e-20 6.096e-18
17 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 260 1656 3.458e-20 9.465e-18
18 REGULATION OF CELLULAR COMPONENT MOVEMENT 150 771 4.18e-20 1.081e-17
19 POSITIVE REGULATION OF GENE EXPRESSION 268 1733 6.918e-20 1.694e-17
20 VASCULATURE DEVELOPMENT 107 469 8.707e-20 2.026e-17
21 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 223 1360 1.338e-19 2.964e-17
22 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 280 1848 1.657e-19 3.505e-17
23 REGULATION OF PROTEIN MODIFICATION PROCESS 264 1710 1.744e-19 3.527e-17
24 RESPONSE TO ENDOGENOUS STIMULUS 233 1450 2.394e-19 4.641e-17
25 CELL CELL ADHESION 125 608 6.563e-19 1.222e-16
26 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 181 1036 7.605e-19 1.311e-16
27 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 181 1036 7.605e-19 1.311e-16
28 POSITIVE REGULATION OF CELL COMMUNICATION 241 1532 8.192e-19 1.361e-16
29 POSITIVE REGULATION OF RESPONSE TO STIMULUS 286 1929 1.411e-18 2.264e-16
30 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 208 1275 4.806e-18 7.454e-16
31 PROTEIN PHOSPHORYLATION 167 944 5.621e-18 8.436e-16
32 SKELETAL SYSTEM DEVELOPMENT 101 455 7.367e-18 1.071e-15
33 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 171 983 1.194e-17 1.683e-15
34 LOCOMOTION 187 1114 1.439e-17 1.97e-15
35 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 267 1805 3.392e-17 4.51e-15
36 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 146 801 5.748e-17 7.429e-15
37 POSITIVE REGULATION OF CATALYTIC ACTIVITY 232 1518 1.333e-16 1.676e-14
38 MUSCLE STRUCTURE DEVELOPMENT 95 432 1.369e-16 1.677e-14
39 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 170 1004 2.144e-16 2.558e-14
40 POSITIVE REGULATION OF CELL DIFFERENTIATION 147 823 2.733e-16 3.179e-14
41 REGULATION OF CELL MORPHOGENESIS 111 552 3.452e-16 3.918e-14
42 NEURON DIFFERENTIATION 153 874 4.026e-16 4.461e-14
43 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 185 1135 4.544e-16 4.917e-14
44 CELLULAR COMPONENT MORPHOGENESIS 156 900 5.005e-16 5.293e-14
45 NEGATIVE REGULATION OF CELL COMMUNICATION 191 1192 8.416e-16 8.702e-14
46 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 226 1492 9.755e-16 9.868e-14
47 PHOSPHORYLATION 195 1228 1.036e-15 1.025e-13
48 REGULATION OF NEURON DIFFERENTIATION 110 554 1.193e-15 1.156e-13
49 REGULATION OF CELL PROLIFERATION 226 1496 1.321e-15 1.255e-13
50 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 258 1784 2.135e-15 1.987e-13
51 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 141 799 3.198e-15 2.918e-13
52 RESPONSE TO OXYGEN CONTAINING COMPOUND 210 1381 7.815e-15 6.993e-13
53 RESPONSE TO NITROGEN COMPOUND 147 859 1.108e-14 9.731e-13
54 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 133 750 1.392e-14 1.199e-12
55 ORGAN MORPHOGENESIS 144 841 2.016e-14 1.705e-12
56 RESPONSE TO WOUNDING 108 563 2.475e-14 2.057e-12
57 CELLULAR RESPONSE TO NITROGEN COMPOUND 100 505 2.942e-14 2.401e-12
58 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 101 513 3.197e-14 2.565e-12
59 BLOOD VESSEL MORPHOGENESIS 80 364 3.709e-14 2.876e-12
60 REGULATION OF OSSIFICATION 51 178 3.682e-14 2.876e-12
61 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 124 689 3.806e-14 2.903e-12
62 REGULATION OF KINASE ACTIVITY 135 776 4.002e-14 3.003e-12
63 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 157 957 5.324e-14 3.86e-12
64 CELL MOTILITY 142 835 5.392e-14 3.86e-12
65 LOCALIZATION OF CELL 142 835 5.392e-14 3.86e-12
66 REGULATION OF CELL PROJECTION ORGANIZATION 106 558 8.396e-14 5.919e-12
67 CELL ACTIVATION 107 568 1.126e-13 7.818e-12
68 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 75 337 1.193e-13 8.162e-12
69 REGULATION OF NEURON PROJECTION DEVELOPMENT 85 408 1.427e-13 9.622e-12
70 HEART DEVELOPMENT 93 466 1.482e-13 9.85e-12
71 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 272 1977 1.533e-13 1.005e-11
72 CENTRAL NERVOUS SYSTEM DEVELOPMENT 145 872 1.791e-13 1.157e-11
73 REGULATION OF GTPASE ACTIVITY 120 673 1.957e-13 1.247e-11
74 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 58 229 2.426e-13 1.525e-11
75 NEURON PROJECTION DEVELOPMENT 103 545 2.666e-13 1.654e-11
76 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 45 153 4.189e-13 2.564e-11
77 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 144 876 5.441e-13 3.288e-11
78 IMMUNE SYSTEM DEVELOPMENT 107 582 5.705e-13 3.403e-11
79 REGULATION OF MAPK CASCADE 117 660 5.95e-13 3.504e-11
80 HEAD DEVELOPMENT 123 709 7.034e-13 4.091e-11
81 MUSCLE TISSUE DEVELOPMENT 64 275 9.189e-13 5.278e-11
82 IMMUNE SYSTEM PROCESS 269 1984 1.171e-12 6.647e-11
83 MUSCLE ORGAN DEVELOPMENT 64 277 1.299e-12 7.196e-11
84 EMBRYO DEVELOPMENT 145 894 1.294e-12 7.196e-11
85 REGULATION OF SYSTEM PROCESS 96 507 1.567e-12 8.578e-11
86 NEURON DEVELOPMENT 119 687 1.882e-12 1.018e-10
87 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 52 204 3.197e-12 1.71e-10
88 NEURON PROJECTION MORPHOGENESIS 81 402 3.369e-12 1.782e-10
89 CELLULAR RESPONSE TO HORMONE STIMULUS 101 552 3.494e-12 1.826e-10
90 BEHAVIOR 96 516 4.52e-12 2.337e-10
91 NEGATIVE REGULATION OF CELL DIFFERENTIATION 108 609 4.658e-12 2.382e-10
92 POSITIVE REGULATION OF LOCOMOTION 83 420 5.281e-12 2.671e-10
93 WOUND HEALING 89 470 1.031e-11 5.16e-10
94 EPITHELIUM DEVELOPMENT 148 945 1.145e-11 5.669e-10
95 REGULATION OF HYDROLASE ACTIVITY 192 1327 1.289e-11 6.312e-10
96 ACTIN FILAMENT BASED PROCESS 86 450 1.4e-11 6.784e-10
97 POSITIVE REGULATION OF CELL PROLIFERATION 132 814 1.417e-11 6.797e-10
98 REGULATION OF CELL DEATH 208 1472 1.527e-11 7.251e-10
99 SINGLE ORGANISM CELL ADHESION 87 459 1.676e-11 7.879e-10
100 POSITIVE REGULATION OF KINASE ACTIVITY 90 482 1.741e-11 8.102e-10
101 POSITIVE REGULATION OF MAPK CASCADE 88 470 2.522e-11 1.162e-09
102 POSITIVE REGULATION OF HYDROLASE ACTIVITY 142 905 2.686e-11 1.225e-09
103 TISSUE MORPHOGENESIS 96 533 3.034e-11 1.371e-09
104 POSITIVE REGULATION OF CELL DEVELOPMENT 88 472 3.184e-11 1.424e-09
105 REGULATION OF TRANSPORT 243 1804 3.461e-11 1.534e-09
106 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 40 144 5.923e-11 2.6e-09
107 GROWTH 79 410 6.318e-11 2.744e-09
108 NEGATIVE REGULATION OF CELL PROLIFERATION 109 643 6.37e-11 2.744e-09
109 REGULATION OF DEVELOPMENTAL GROWTH 62 289 8.139e-11 3.474e-09
110 REGULATION OF TRANSFERASE ACTIVITY 145 946 9.174e-11 3.88e-09
111 DEVELOPMENTAL GROWTH 68 333 1.006e-10 4.217e-09
112 RESPONSE TO GROWTH FACTOR 87 475 1.071e-10 4.449e-09
113 EMBRYONIC MORPHOGENESIS 95 539 1.311e-10 5.399e-09
114 ANGIOGENESIS 62 293 1.477e-10 6.03e-09
115 RESPONSE TO HORMONE 138 893 1.521e-10 6.154e-09
116 REGULATION OF CELL ADHESION 106 629 1.671e-10 6.704e-09
117 NEGATIVE REGULATION OF CELL DEATH 135 872 2.151e-10 8.556e-09
118 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 49 207 2.257e-10 8.899e-09
119 SINGLE ORGANISM BEHAVIOR 74 384 2.533e-10 9.888e-09
120 RESPONSE TO OXYGEN LEVELS 64 311 2.55e-10 9.888e-09
121 NEGATIVE REGULATION OF PHOSPHORYLATION 79 422 2.675e-10 1.028e-08
122 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 85 470 3.384e-10 1.291e-08
123 FOREBRAIN DEVELOPMENT 70 357 3.522e-10 1.332e-08
124 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 94 541 3.598e-10 1.339e-08
125 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 94 541 3.598e-10 1.339e-08
126 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 159 1087 3.904e-10 1.442e-08
127 TUBE DEVELOPMENT 95 552 4.883e-10 1.789e-08
128 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 166 1152 4.921e-10 1.789e-08
129 ARTERY DEVELOPMENT 26 75 7.174e-10 2.588e-08
130 CYTOSKELETON ORGANIZATION 129 838 8.009e-10 2.867e-08
131 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 37 138 9.162e-10 3.254e-08
132 POSITIVE REGULATION OF NEURON DIFFERENTIATION 62 306 9.293e-10 3.276e-08
133 LEUKOCYTE DIFFERENTIATION 60 292 9.796e-10 3.427e-08
134 CELL PROJECTION ORGANIZATION 136 902 1.098e-09 3.814e-08
135 RESPONSE TO PEPTIDE 75 404 1.121e-09 3.864e-08
136 LEUKOCYTE ACTIVATION 76 414 1.467e-09 5.021e-08
137 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 138 926 1.793e-09 6.088e-08
138 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 116 740 2.03e-09 6.844e-08
139 REGULATION OF OSTEOBLAST DIFFERENTIATION 32 112 2.22e-09 7.432e-08
140 CONNECTIVE TISSUE DEVELOPMENT 45 194 2.416e-09 8.029e-08
141 CELLULAR RESPONSE TO OXYGEN LEVELS 37 143 2.681e-09 8.847e-08
142 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 40 162 2.719e-09 8.909e-08
143 COGNITION 53 251 3.408e-09 1.087e-07
144 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 78 437 3.353e-09 1.087e-07
145 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 69 368 3.378e-09 1.087e-07
146 MUSCLE CELL DIFFERENTIATION 51 237 3.41e-09 1.087e-07
147 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 44 190 3.825e-09 1.211e-07
148 REGULATION OF RESPONSE TO STRESS 197 1468 4.374e-09 1.375e-07
149 EXTRACELLULAR STRUCTURE ORGANIZATION 60 304 4.913e-09 1.534e-07
150 CELL JUNCTION ORGANIZATION 43 185 5.092e-09 1.579e-07
151 LYMPHOCYTE ACTIVATION 65 342 5.508e-09 1.697e-07
152 CIRCULATORY SYSTEM PROCESS 68 366 6.458e-09 1.977e-07
153 RESPONSE TO EXTERNAL STIMULUS 234 1821 6.73e-09 2.047e-07
154 SENSORY ORGAN DEVELOPMENT 84 493 8.054e-09 2.433e-07
155 REGULATION OF CELLULAR COMPONENT BIOGENESIS 117 767 8.603e-09 2.583e-07
156 REGULATION OF ION TRANSPORT 96 592 9.349e-09 2.789e-07
157 BONE DEVELOPMENT 38 156 1.005e-08 2.977e-07
158 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 59 303 1.107e-08 3.261e-07
159 REGULATION OF IMMUNE SYSTEM PROCESS 188 1403 1.15e-08 3.347e-07
160 CELLULAR RESPONSE TO PEPTIDE 55 274 1.151e-08 3.347e-07
161 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 80 465 1.176e-08 3.399e-07
162 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 49 232 1.307e-08 3.755e-07
163 CELL DEATH 143 1001 1.49e-08 4.241e-07
164 REGULATION OF MEMBRANE POTENTIAL 64 343 1.511e-08 4.241e-07
165 RHYTHMIC PROCESS 58 298 1.497e-08 4.241e-07
166 REGULATION OF VASCULATURE DEVELOPMENT 49 233 1.513e-08 4.241e-07
167 NEGATIVE REGULATION OF GENE EXPRESSION 197 1493 1.661e-08 4.627e-07
168 UROGENITAL SYSTEM DEVELOPMENT 58 299 1.697e-08 4.7e-07
169 CELL PART MORPHOGENESIS 100 633 1.809e-08 4.952e-07
170 REGULATION OF GROWTH 100 633 1.809e-08 4.952e-07
171 TELENCEPHALON DEVELOPMENT 48 228 2.042e-08 5.555e-07
172 REGULATION OF BLOOD CIRCULATION 57 295 2.598e-08 7.028e-07
173 REGULATION OF AXONOGENESIS 39 168 2.691e-08 7.238e-07
174 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 37 156 3.334e-08 8.866e-07
175 INOSITOL LIPID MEDIATED SIGNALING 32 124 3.334e-08 8.866e-07
176 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 97 616 3.489e-08 9.225e-07
177 FAT CELL DIFFERENTIATION 29 106 3.603e-08 9.417e-07
178 STEM CELL DIFFERENTIATION 42 190 3.6e-08 9.417e-07
179 CHEMICAL HOMEOSTASIS 127 874 3.706e-08 9.634e-07
180 HEART MORPHOGENESIS 45 212 4.325e-08 1.118e-06
181 NEGATIVE REGULATION OF LOCOMOTION 52 263 4.818e-08 1.239e-06
182 REGULATION OF ANATOMICAL STRUCTURE SIZE 79 472 4.94e-08 1.263e-06
183 TAXIS 78 464 4.968e-08 1.263e-06
184 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 89 554 5.073e-08 1.283e-06
185 CELLULAR RESPONSE TO LIPID 77 457 5.48e-08 1.378e-06
186 RESPONSE TO ORGANIC CYCLIC COMPOUND 131 917 6.178e-08 1.545e-06
187 CARTILAGE DEVELOPMENT 35 147 7.006e-08 1.743e-06
188 CELLULAR HOMEOSTASIS 103 676 7.237e-08 1.791e-06
189 REGULATION OF RESPONSE TO WOUNDING 71 413 8.018e-08 1.974e-06
190 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 74 437 8.065e-08 1.975e-06
191 CELLULAR RESPONSE TO ACID CHEMICAL 39 175 8.697e-08 2.119e-06
192 CELL JUNCTION ASSEMBLY 32 129 9.112e-08 2.208e-06
193 MORPHOGENESIS OF AN EPITHELIUM 69 400 1.064e-07 2.565e-06
194 RESPONSE TO ABIOTIC STIMULUS 142 1024 1.07e-07 2.565e-06
195 POSITIVE REGULATION OF CELL DEATH 94 605 1.082e-07 2.582e-06
196 REGULATION OF BODY FLUID LEVELS 82 506 1.164e-07 2.763e-06
197 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 95 616 1.321e-07 3.12e-06
198 CARDIAC CHAMBER DEVELOPMENT 34 144 1.331e-07 3.129e-06
199 LEARNING 32 131 1.338e-07 3.129e-06
200 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 195 1517 1.401e-07 3.26e-06
201 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 27 100 1.42e-07 3.288e-06
202 REGULATION OF CELL SIZE 38 172 1.609e-07 3.706e-06
203 REGULATION OF STEM CELL DIFFERENTIATION 29 113 1.647e-07 3.774e-06
204 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 26 95 1.794e-07 4.092e-06
205 EMBRYONIC ORGAN DEVELOPMENT 69 406 1.91e-07 4.336e-06
206 PALLIUM DEVELOPMENT 35 153 2.006e-07 4.531e-06
207 MUSCLE SYSTEM PROCESS 53 282 2.016e-07 4.532e-06
208 REGULATION OF CYTOKINE PRODUCTION 88 563 2.109e-07 4.718e-06
209 LYMPHOCYTE DIFFERENTIATION 43 209 2.161e-07 4.812e-06
210 POSITIVE REGULATION OF OSSIFICATION 24 84 2.196e-07 4.865e-06
211 REGULATION OF MUSCLE SYSTEM PROCESS 41 195 2.226e-07 4.909e-06
212 REPRODUCTIVE SYSTEM DEVELOPMENT 69 408 2.312e-07 5.075e-06
213 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 80 498 2.405e-07 5.254e-06
214 RESPONSE TO MECHANICAL STIMULUS 43 210 2.485e-07 5.403e-06
215 REGULATION OF FATTY ACID OXIDATION 13 28 2.536e-07 5.489e-06
216 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 46 232 2.581e-07 5.56e-06
217 REGULATION OF EPITHELIAL CELL PROLIFERATION 53 285 2.861e-07 6.134e-06
218 LEUKOCYTE CELL CELL ADHESION 49 255 2.883e-07 6.153e-06
219 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 52 278 3.058e-07 6.497e-06
220 HOMEOSTATIC PROCESS 174 1337 3.127e-07 6.614e-06
221 REGULATION OF CATABOLIC PROCESS 107 731 3.143e-07 6.617e-06
222 REGULATION OF MUSCLE ADAPTATION 20 63 3.402e-07 7.131e-06
223 ACTIVATION OF PROTEIN KINASE ACTIVITY 52 279 3.435e-07 7.168e-06
224 CELL FATE COMMITMENT 45 227 3.489e-07 7.248e-06
225 CELLULAR CHEMICAL HOMEOSTASIS 88 570 3.654e-07 7.557e-06
226 COLLAGEN FIBRIL ORGANIZATION 15 38 4.132e-07 8.433e-06
227 RESPONSE TO ACID CHEMICAL 57 319 4.12e-07 8.433e-06
228 REGULATION OF MAP KINASE ACTIVITY 57 319 4.12e-07 8.433e-06
229 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 26 99 4.35e-07 8.801e-06
230 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 26 99 4.35e-07 8.801e-06
231 POSITIVE REGULATION OF CELL ADHESION 64 376 4.971e-07 1.001e-05
232 POSITIVE REGULATION OF GROWTH 46 238 5.55e-07 1.113e-05
233 REGULATION OF EXTENT OF CELL GROWTH 26 101 6.63e-07 1.324e-05
234 MESENCHYMAL CELL DIFFERENTIATION 31 134 7.552e-07 1.502e-05
235 REGULATION OF METAL ION TRANSPORT 57 325 7.716e-07 1.528e-05
236 REGULATION OF INFLAMMATORY RESPONSE 53 294 7.836e-07 1.545e-05
237 RESPONSE TO LIPID 123 888 8.33e-07 1.635e-05
238 CELLULAR RESPONSE TO EXTERNAL STIMULUS 49 264 8.416e-07 1.645e-05
239 ENDOTHELIAL CELL DIFFERENTIATION 21 72 8.513e-07 1.657e-05
240 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 17 50 8.634e-07 1.674e-05
241 ENDOTHELIUM DEVELOPMENT 24 90 8.848e-07 1.708e-05
242 REGULATION OF MUSCLE TISSUE DEVELOPMENT 26 103 9.968e-07 1.917e-05
243 GLAND MORPHOGENESIS 25 97 1.055e-06 2.021e-05
244 REGULATION OF HEART CONTRACTION 43 221 1.066e-06 2.033e-05
245 OSSIFICATION 47 251 1.08e-06 2.051e-05
246 SKELETAL MUSCLE ORGAN DEVELOPMENT 31 137 1.256e-06 2.376e-05
247 AORTA DEVELOPMENT 15 41 1.306e-06 2.46e-05
248 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 66 404 1.479e-06 2.776e-05
249 SYNAPSE ORGANIZATION 32 145 1.526e-06 2.851e-05
250 STRIATED MUSCLE CELL DIFFERENTIATION 36 173 1.542e-06 2.865e-05
251 RESPONSE TO INORGANIC SUBSTANCE 75 479 1.546e-06 2.865e-05
252 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 35 166 1.558e-06 2.878e-05
253 LIPID PHOSPHORYLATION 25 99 1.588e-06 2.92e-05
254 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 48 262 1.594e-06 2.921e-05
255 RESPONSE TO AMINO ACID 27 112 1.643e-06 2.998e-05
256 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 61 365 1.71e-06 3.107e-05
257 POSITIVE REGULATION OF AXONOGENESIS 20 69 1.721e-06 3.117e-05
258 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 103 724 1.986e-06 3.582e-05
259 NEGATIVE REGULATION OF CELL DEVELOPMENT 53 303 2.021e-06 3.631e-05
260 NEGATIVE REGULATION OF MOLECULAR FUNCTION 142 1079 2.211e-06 3.958e-05
261 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 51 289 2.402e-06 4.27e-05
262 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 31 141 2.405e-06 4.27e-05
263 LEUKOCYTE MIGRATION 47 259 2.68e-06 4.742e-05
264 EPITHELIAL CELL DIFFERENTIATION 76 495 2.796e-06 4.928e-05
265 RESPONSE TO INTERLEUKIN 1 27 115 2.833e-06 4.974e-05
266 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 25 102 2.858e-06 5e-05
267 REGULATION OF BINDING 50 283 2.901e-06 5.056e-05
268 TUBE MORPHOGENESIS 55 323 3.054e-06 5.303e-05
269 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 30 136 3.234e-06 5.594e-05
270 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 18 60 3.265e-06 5.627e-05
271 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 16 49 3.32e-06 5.701e-05
272 REGULATION OF MUSCLE ORGAN DEVELOPMENT 25 103 3.455e-06 5.91e-05
273 MODULATION OF SYNAPTIC TRANSMISSION 52 301 3.658e-06 6.234e-05
274 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 14 39 3.825e-06 6.496e-05
275 EYE DEVELOPMENT 55 326 4.068e-06 6.884e-05
276 CARDIAC SEPTUM DEVELOPMENT 22 85 4.269e-06 7.196e-05
277 REGULATION OF EPITHELIAL CELL MIGRATION 34 166 4.305e-06 7.232e-05
278 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 19 67 4.45e-06 7.448e-05
279 HEMOSTASIS 53 311 4.475e-06 7.463e-05
280 MEMORY 24 98 4.556e-06 7.57e-05
281 AGING 47 264 4.6e-06 7.617e-05
282 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 58 352 4.791e-06 7.905e-05
283 MORPHOGENESIS OF A BRANCHING STRUCTURE 34 167 4.945e-06 8.13e-05
284 KIDNEY EPITHELIUM DEVELOPMENT 28 125 4.969e-06 8.141e-05
285 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 17 56 5.092e-06 8.314e-05
286 REGULATION OF CELLULAR COMPONENT SIZE 56 337 5.351e-06 8.706e-05
287 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 117 867 5.511e-06 8.934e-05
288 RESPONSE TO CYTOKINE 100 714 5.56e-06 8.983e-05
289 GLAND DEVELOPMENT 63 395 5.682e-06 9.148e-05
290 MESENCHYME DEVELOPMENT 37 190 5.738e-06 9.207e-05
291 REGULATION OF LIPID METABOLIC PROCESS 49 282 5.856e-06 9.363e-05
292 INFLAMMATORY RESPONSE 70 454 5.897e-06 9.396e-05
293 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 29 133 5.968e-06 9.433e-05
294 REGULATION OF HEMOPOIESIS 53 314 5.964e-06 9.433e-05
295 ARTERY MORPHOGENESIS 16 51 5.981e-06 9.433e-05
296 CARDIAC MUSCLE TISSUE DEVELOPMENT 30 140 6.019e-06 9.461e-05
297 APPENDAGE DEVELOPMENT 34 169 6.494e-06 0.0001014
298 LIMB DEVELOPMENT 34 169 6.494e-06 0.0001014
299 REGULATION OF LEUKOCYTE PROLIFERATION 39 206 6.578e-06 0.0001024
300 REGULATION OF CHONDROCYTE DIFFERENTIATION 15 46 6.832e-06 0.000106
301 PEPTIDYL SERINE MODIFICATION 31 148 6.951e-06 0.0001074
302 REGULATION OF CELLULAR RESPONSE TO STRESS 97 691 6.969e-06 0.0001074
303 REGULATION OF CARTILAGE DEVELOPMENT 18 63 7.032e-06 0.000108
304 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 20 75 7.062e-06 0.0001081
305 NEGATIVE REGULATION OF OSSIFICATION 19 69 7.154e-06 0.0001091
306 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 23 94 7.265e-06 0.0001105
307 ESTABLISHMENT OF CELL POLARITY 22 88 7.861e-06 0.0001176
308 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 27 121 7.858e-06 0.0001176
309 LEUKOCYTE PROLIFERATION 22 88 7.861e-06 0.0001176
310 POSITIVE REGULATION OF FATTY ACID OXIDATION 8 14 7.82e-06 0.0001176
311 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 96 684 7.825e-06 0.0001176
312 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 37 193 8.345e-06 0.0001244
313 SECRETION 85 588 8.388e-06 0.0001247
314 SMOOTH MUSCLE TISSUE DEVELOPMENT 9 18 8.783e-06 0.0001302
315 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 26 115 8.948e-06 0.0001322
316 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 19 70 8.996e-06 0.0001325
317 SECRETION BY CELL 73 486 9.585e-06 0.0001407
318 IMMUNE RESPONSE 141 1100 9.76e-06 0.0001428
319 RESPONSE TO OXIDATIVE STRESS 57 352 9.848e-06 0.0001436
320 CELLULAR RESPONSE TO AMINO ACID STIMULUS 16 53 1.04e-05 0.0001503
321 REGULATION OF HEART GROWTH 14 42 1.035e-05 0.0001503
322 RESPONSE TO PURINE CONTAINING COMPOUND 32 158 1.039e-05 0.0001503
323 REGULATION OF ACTIN FILAMENT BASED PROCESS 52 312 1.05e-05 0.0001512
324 MUSCLE CONTRACTION 42 233 1.057e-05 0.0001513
325 CARDIOCYTE DIFFERENTIATION 23 96 1.057e-05 0.0001513
326 T CELL DIFFERENTIATION 27 123 1.083e-05 0.0001546
327 REGULATION OF BMP SIGNALING PATHWAY 20 77 1.087e-05 0.0001546
328 REGULATION OF AUTOPHAGY 44 249 1.111e-05 0.0001576
329 NEGATIVE REGULATION OF KINASE ACTIVITY 44 250 1.233e-05 0.0001744
330 REGULATION OF HOMEOSTATIC PROCESS 68 447 1.256e-05 0.0001771
331 SEX DIFFERENTIATION 46 266 1.267e-05 0.0001781
332 MYELOID CELL DIFFERENTIATION 36 189 1.275e-05 0.0001787
333 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 59 372 1.322e-05 0.0001848
334 CARDIAC CHAMBER MORPHOGENESIS 24 104 1.355e-05 0.0001877
335 ALPHA BETA T CELL ACTIVATION 16 54 1.355e-05 0.0001877
336 RESPONSE TO DRUG 66 431 1.351e-05 0.0001877
337 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 17 60 1.421e-05 0.0001939
338 RESPONSE TO INSULIN 38 205 1.421e-05 0.0001939
339 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 14 43 1.408e-05 0.0001939
340 CHONDROCYTE DIFFERENTIATION 17 60 1.421e-05 0.0001939
341 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 17 60 1.421e-05 0.0001939
342 CELLULAR RESPONSE TO INSULIN STIMULUS 30 146 1.443e-05 0.0001964
343 REGULATION OF TRANSPORTER ACTIVITY 37 198 1.521e-05 0.0002063
344 CEREBRAL CORTEX DEVELOPMENT 24 105 1.608e-05 0.0002175
345 RESPONSE TO REACTIVE OXYGEN SPECIES 36 191 1.622e-05 0.0002187
346 SYSTEM PROCESS 211 1785 1.642e-05 0.0002209
347 PROTEIN LOCALIZATION 213 1805 1.665e-05 0.0002233
348 REGULATION OF SYNAPTIC PLASTICITY 29 140 1.696e-05 0.0002268
349 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 27 126 1.724e-05 0.0002298
350 REGULATION OF ORGAN GROWTH 19 73 1.735e-05 0.0002307
351 REGULATION OF TRANSMEMBRANE TRANSPORT 65 426 1.759e-05 0.0002331
352 OVULATION CYCLE 25 113 1.964e-05 0.0002597
353 IN UTERO EMBRYONIC DEVELOPMENT 51 311 2.001e-05 0.0002637
354 MULTICELLULAR ORGANISM METABOLIC PROCESS 22 93 2.022e-05 0.0002658
355 EMBRYONIC ORGAN MORPHOGENESIS 47 279 2.066e-05 0.0002708
356 ION HOMEOSTASIS 82 576 2.121e-05 0.0002773
357 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 23 100 2.154e-05 0.0002807
358 REGULATION OF FATTY ACID METABOLIC PROCESS 21 87 2.235e-05 0.0002899
359 ORGAN GROWTH 18 68 2.237e-05 0.0002899
360 PLATELET ACTIVATION 29 142 2.247e-05 0.0002904
361 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 12 34 2.3e-05 0.0002955
362 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 11 29 2.305e-05 0.0002955
363 RESPONSE TO ISCHEMIA 11 29 2.305e-05 0.0002955
364 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 33 172 2.468e-05 0.0003155
365 POSITIVE REGULATION OF VACUOLE ORGANIZATION 7 12 2.512e-05 0.0003202
366 POSITIVE REGULATION OF AUTOPHAGY 19 75 2.626e-05 0.0003329
367 NEURAL CREST CELL DIFFERENTIATION 19 75 2.626e-05 0.0003329
368 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 62 406 2.654e-05 0.0003356
369 PHOSPHOLIPID METABOLIC PROCESS 57 364 2.678e-05 0.0003377
370 GLYCEROLIPID METABOLIC PROCESS 56 356 2.755e-05 0.0003455
371 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 46 274 2.75e-05 0.0003455
372 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 35 188 2.772e-05 0.0003467
373 NEGATIVE REGULATION OF TRANSPORT 68 458 2.794e-05 0.0003485
374 REGULATION OF CELL ACTIVATION 71 484 2.806e-05 0.0003491
375 REGULATION OF SECRETION 95 699 3.172e-05 0.0003925
376 CHONDROITIN SULFATE BIOSYNTHETIC PROCESS 10 25 3.169e-05 0.0003925
377 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 40 228 3.239e-05 0.0003997
378 PEPTIDYL THREONINE MODIFICATION 14 46 3.329e-05 0.0004098
379 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 11 30 3.344e-05 0.0004105
380 NEURON PROJECTION GUIDANCE 37 205 3.358e-05 0.0004112
381 PATTERN SPECIFICATION PROCESS 63 418 3.441e-05 0.0004203
382 SECOND MESSENGER MEDIATED SIGNALING 31 160 3.524e-05 0.0004292
383 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 23 103 3.56e-05 0.0004326
384 NEURON MIGRATION 24 110 3.638e-05 0.0004408
385 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 35 191 3.909e-05 0.0004712
386 ACTOMYOSIN STRUCTURE ORGANIZATION 19 77 3.904e-05 0.0004712
387 REGENERATION 31 161 3.994e-05 0.0004802
388 REGULATION OF ERK1 AND ERK2 CASCADE 41 238 4.013e-05 0.0004813
389 REGULATION OF ENDOCYTOSIS 36 199 4.051e-05 0.0004846
390 REGIONALIZATION 50 311 4.089e-05 0.0004878
391 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 30 154 4.205e-05 0.0004992
392 ADHERENS JUNCTION ORGANIZATION 18 71 4.203e-05 0.0004992
393 POSITIVE REGULATION OF AXON EXTENSION 12 36 4.428e-05 0.0005229
394 T CELL SELECTION 12 36 4.428e-05 0.0005229
395 RESPONSE TO ALCOHOL 56 362 4.441e-05 0.0005232
396 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 38 216 4.737e-05 0.0005565
397 NEGATIVE REGULATION OF ANOIKIS 8 17 4.943e-05 0.0005779
398 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 17 4.943e-05 0.0005779
399 RESPONSE TO PARATHYROID HORMONE 7 13 5.018e-05 0.0005852
400 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 48 297 5.048e-05 0.0005857
401 SKELETAL SYSTEM MORPHOGENESIS 36 201 5.037e-05 0.0005857
402 NEGATIVE REGULATION OF NEURON DEATH 32 171 5.406e-05 0.0006258
403 LENS DEVELOPMENT IN CAMERA TYPE EYE 17 66 5.481e-05 0.0006329
404 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 14 48 5.637e-05 0.0006493
405 LIPID MODIFICATION 37 210 5.728e-05 0.0006534
406 REGULATION OF FAT CELL DIFFERENTIATION 23 106 5.743e-05 0.0006534
407 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 19 79 5.708e-05 0.0006534
408 CARDIAC VENTRICLE DEVELOPMENT 23 106 5.743e-05 0.0006534
409 REGULATION OF DENDRITE DEVELOPMENT 25 120 5.705e-05 0.0006534
410 REGULATION OF CELL GROWTH 59 391 5.82e-05 0.0006589
411 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 38 218 5.819e-05 0.0006589
412 REGULATION OF HOMOTYPIC CELL CELL ADHESION 49 307 5.863e-05 0.0006621
413 REGULATION OF MUSCLE HYPERTROPHY 12 37 6.018e-05 0.0006781
414 REGULATION OF CHEMOTAXIS 33 180 6.352e-05 0.0007139
415 BONE CELL DEVELOPMENT 9 22 6.439e-05 0.0007202
416 CEREBELLAR CORTEX FORMATION 9 22 6.439e-05 0.0007202
417 VESICLE MEDIATED TRANSPORT 151 1239 6.576e-05 0.0007329
418 NEGATIVE REGULATION OF IMMUNE RESPONSE 25 121 6.584e-05 0.0007329
419 RESPONSE TO STEROID HORMONE 71 497 6.639e-05 0.0007373
420 POSITIVE REGULATION OF ENDOCYTOSIS 24 114 6.681e-05 0.0007402
421 AMINOGLYCAN BIOSYNTHETIC PROCESS 23 107 6.701e-05 0.0007406
422 RAS PROTEIN SIGNAL TRANSDUCTION 28 143 6.796e-05 0.0007493
423 REGULATION OF CELL SUBSTRATE ADHESION 32 173 6.824e-05 0.0007505
424 CHONDROITIN SULFATE PROTEOGLYCAN METABOLIC PROCESS 13 43 6.838e-05 0.0007505
425 POSITIVE REGULATION OF HEART GROWTH 10 27 6.915e-05 0.0007534
426 HIPPO SIGNALING 10 27 6.915e-05 0.0007534
427 SUBSTRATE DEPENDENT CELL MIGRATION 10 27 6.915e-05 0.0007534
428 POSITIVE REGULATION OF TRANSPORT 119 936 6.93e-05 0.0007534
429 MEMBRANE DEPOLARIZATION 16 61 7.108e-05 0.000771
430 REGULATION OF NEURON DEATH 42 252 7.137e-05 0.0007723
431 GLOMERULUS DEVELOPMENT 14 49 7.243e-05 0.000782
432 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 15 55 7.304e-05 0.0007855
433 TISSUE REMODELING 20 87 7.309e-05 0.0007855
434 RESPIRATORY SYSTEM DEVELOPMENT 35 197 7.538e-05 0.0008081
435 ACTION POTENTIAL 21 94 7.605e-05 0.0008135
436 NEPHRON DEVELOPMENT 24 115 7.732e-05 0.0008233
437 RESPONSE TO CALCIUM ION 24 115 7.732e-05 0.0008233
438 REGULATION OF CELL JUNCTION ASSEMBLY 17 68 8.234e-05 0.0008747
439 REGULATION OF MUSCLE CELL DIFFERENTIATION 29 152 8.285e-05 0.0008781
440 CELLULAR RESPONSE TO INTERLEUKIN 1 20 88 8.668e-05 0.0009146
441 OVULATION CYCLE PROCESS 20 88 8.668e-05 0.0009146
442 CELL PROLIFERATION 90 672 8.691e-05 0.0009149
443 CARDIAC VENTRICLE MORPHOGENESIS 16 62 8.788e-05 0.0009209
444 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 16 62 8.788e-05 0.0009209
445 AMINO ACID BETAINE TRANSPORT 7 14 9.254e-05 0.0009676
446 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 47 296 9.337e-05 0.0009714
447 REGULATION OF PROTEIN SECRETION 58 389 9.369e-05 0.0009714
448 REGULATION OF CELLULAR LOCALIZATION 154 1277 9.373e-05 0.0009714
449 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 29 153 9.357e-05 0.0009714
450 NEGATIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 10 28 9.891e-05 0.001018
451 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 33 184 9.889e-05 0.001018
452 CELLULAR RESPONSE TO OXIDATIVE STRESS 33 184 9.889e-05 0.001018
453 CELLULAR RESPONSE TO STARVATION 24 117 0.0001029 0.001057
454 CELL CYCLE ARREST 29 154 0.0001055 0.001075
455 REGULATION OF CIRCADIAN RHYTHM 22 103 0.0001056 0.001075
456 REGULATION OF LEUKOCYTE DIFFERENTIATION 39 232 0.0001053 0.001075
457 RESPONSE TO STARVATION 29 154 0.0001055 0.001075
458 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 12 39 0.0001072 0.001087
459 TRABECULA MORPHOGENESIS 12 39 0.0001072 0.001087
460 DEVELOPMENTAL MATURATION 34 193 0.0001125 0.001138
461 ALPHA BETA T CELL DIFFERENTIATION 13 45 0.0001151 0.001161
462 GLUCOSE HOMEOSTASIS 31 170 0.0001156 0.001162
463 CARBOHYDRATE HOMEOSTASIS 31 170 0.0001156 0.001162
464 PROTEOGLYCAN METABOLIC PROCESS 19 83 0.0001165 0.001168
465 MUSCLE ORGAN MORPHOGENESIS 17 70 0.0001213 0.001214
466 EPITHELIAL CELL DEVELOPMENT 33 186 0.0001225 0.001223
467 MUSCLE CELL CELLULAR HOMEOSTASIS 8 19 0.0001304 0.001299
468 REGULATION OF SODIUM ION TRANSPORT 18 77 0.0001313 0.001305
469 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 106 829 0.0001373 0.001362
470 DIVALENT INORGANIC CATION HOMEOSTASIS 52 343 0.0001381 0.001367
471 PROTEOGLYCAN BIOSYNTHETIC PROCESS 15 58 0.0001411 0.001394
472 REGULATION OF MYELOID CELL APOPTOTIC PROCESS 9 24 0.0001433 0.00141
473 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 21 98 0.0001431 0.00141
474 REGULATION OF WNT SIGNALING PATHWAY 48 310 0.0001474 0.001446
475 POSITIVE REGULATION OF BINDING 25 127 0.0001491 0.00146
476 POSITIVE REGULATION OF CYTOKINE PRODUCTION 55 370 0.0001521 0.001486
477 REGULATION OF BEHAVIOR 16 65 0.0001608 0.001562
478 REGULATION OF SYNAPSE ORGANIZATION 23 113 0.0001606 0.001562
479 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 16 65 0.0001608 0.001562
480 HEART PROCESS 19 85 0.0001629 0.001579
481 POSITIVE REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 6 11 0.0001646 0.001589
482 CD4 POSITIVE OR CD8 POSITIVE ALPHA BETA T CELL LINEAGE COMMITMENT 6 11 0.0001646 0.001589
483 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 81 602 0.0001656 0.001595
484 REGULATION OF CELL CELL ADHESION 56 380 0.0001675 0.00161
485 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 34 197 0.0001694 0.001625
486 REGULATION OF LIPID STORAGE 12 41 0.0001827 0.001738
487 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 12 41 0.0001827 0.001738
488 REGULATION OF VACUOLE ORGANIZATION 12 41 0.0001827 0.001738
489 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 14 53 0.000183 0.001738
490 LUNG ALVEOLUS DEVELOPMENT 12 41 0.0001827 0.001738
491 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 18 79 0.0001858 0.001761
492 CHONDROITIN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS 10 30 0.0001915 0.001804
493 NEGATIVE REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 10 30 0.0001915 0.001804
494 NEGATIVE REGULATION OF TOR SIGNALING 10 30 0.0001915 0.001804
495 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 16 66 0.0001947 0.001816
496 REGULATION OF DNA BINDING 20 93 0.0001939 0.001816
497 NEGATIVE REGULATION OF DEFENSE RESPONSE 27 144 0.0001934 0.001816
498 REGULATION OF PROTEIN LOCALIZATION 118 950 0.0001946 0.001816
499 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 16 66 0.0001947 0.001816
500 RESPONSE TO LEPTIN 8 20 0.0002002 0.001863
501 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 24 122 0.0002024 0.001876
502 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 24 122 0.0002024 0.001876
503 REGULATION OF MYELOID CELL DIFFERENTIATION 32 183 0.0002029 0.001877
504 POSTSYNAPTIC MEMBRANE ORGANIZATION 9 25 0.0002061 0.001903
505 REGULATION OF PROTEIN BINDING 30 168 0.0002168 0.001994
506 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 30 168 0.0002168 0.001994
507 NEGATIVE REGULATION OF MAPK CASCADE 27 145 0.0002176 0.001997
508 MUCOPOLYSACCHARIDE METABOLIC PROCESS 22 108 0.0002182 0.001999
509 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 11 36 0.0002216 0.002026
510 CARDIAC MUSCLE TISSUE MORPHOGENESIS 14 54 0.0002268 0.002066
511 PROTEIN AUTOPHOSPHORYLATION 33 192 0.0002269 0.002066
512 RESPONSE TO METAL ION 50 333 0.0002326 0.002114
513 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 12 42 0.000235 0.002123
514 POSITIVE REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 13 48 0.0002355 0.002123
515 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 13 48 0.0002355 0.002123
516 POSITIVE REGULATION OF RESPONSE TO NUTRIENT LEVELS 13 48 0.0002355 0.002123
517 REGULATION OF BLOOD PRESSURE 30 169 0.0002413 0.002167
518 FEMALE SEX DIFFERENTIATION 23 116 0.0002412 0.002167
519 WNT SIGNALING PATHWAY 52 351 0.0002468 0.002213
520 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 25 131 0.0002474 0.002213
521 CELL CELL SIGNALING 98 767 0.0002492 0.002226
522 CARDIAC MUSCLE CELL DIFFERENTIATION 17 74 0.0002501 0.002229
523 RESPONSE TO HYDROGEN PEROXIDE 22 109 0.0002505 0.002229
524 AMEBOIDAL TYPE CELL MIGRATION 28 154 0.0002543 0.002259
525 POSITIVE REGULATION OF STEM CELL PROLIFERATION 15 61 0.0002585 0.002291
526 REGULATION OF FATTY ACID BETA OXIDATION 7 16 0.0002624 0.002321
527 REGULATION OF STEM CELL PROLIFERATION 19 88 0.0002629 0.002321
528 ANTERIOR POSTERIOR PATTERN SPECIFICATION 33 194 0.0002762 0.002434
529 CRANIAL SKELETAL SYSTEM DEVELOPMENT 14 55 0.0002793 0.002457
530 RESPONSE TO EXTRACELLULAR STIMULUS 62 441 0.0002909 0.002553
531 VASCULAR PROCESS IN CIRCULATORY SYSTEM 29 163 0.000292 0.002559
532 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 13 49 0.0002943 0.002574
533 CELL DIFFERENTIATION IN HINDBRAIN 8 21 0.0002979 0.002601
534 CELL FATE DETERMINATION 12 43 0.0002995 0.00261
535 MYELOID LEUKOCYTE DIFFERENTIATION 20 96 0.0003035 0.002614
536 PLASMA MEMBRANE ORGANIZATION 34 203 0.0003035 0.002614
537 CARTILAGE MORPHOGENESIS 6 12 0.000304 0.002614
538 EAR DEVELOPMENT 33 195 0.0003043 0.002614
539 POSITIVE REGULATION OF CELL ACTIVATION 47 311 0.0003037 0.002614
540 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 6 12 0.000304 0.002614
541 INTEGRIN MEDIATED SIGNALING PATHWAY 18 82 0.0003045 0.002614
542 NEGATIVE REGULATION OF CATABOLIC PROCESS 34 203 0.0003035 0.002614
543 POST EMBRYONIC DEVELOPMENT 19 89 0.0003065 0.002626
544 POSITIVE REGULATION OF CELL GROWTH 27 148 0.0003072 0.002627
545 REGULATION OF HORMONE LEVELS 66 478 0.0003152 0.002687
546 NEGATIVE REGULATION OF GROWTH 38 236 0.0003153 0.002687
547 CELL SUBSTRATE ADHESION 29 164 0.0003248 0.002763
548 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 30 172 0.0003302 0.002804
549 OSTEOBLAST DIFFERENTIATION 24 126 0.0003357 0.002845
550 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 21 104 0.0003407 0.002882
551 SMAD PROTEIN SIGNAL TRANSDUCTION 14 56 0.0003419 0.002887
552 REGULATION OF HORMONE SECRETION 41 262 0.0003458 0.002915
553 SALIVARY GLAND DEVELOPMENT 10 32 0.000348 0.002923
554 NEGATIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 10 32 0.000348 0.002923
555 NEUROMUSCULAR PROCESS 20 97 0.0003505 0.002938
556 MESONEPHROS DEVELOPMENT 19 90 0.0003562 0.002981
557 PEPTIDYL AMINO ACID MODIFICATION 105 841 0.0003587 0.002996
558 CELLULAR RESPONSE TO CAMP 13 50 0.0003653 0.003046
559 LOCOMOTORY BEHAVIOR 31 181 0.0003684 0.003067
560 REGULATION OF ORGANELLE ORGANIZATION 140 1178 0.0003695 0.00307
561 NEGATIVE REGULATION OF INNATE IMMUNE RESPONSE 11 38 0.0003751 0.003106
562 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 11 38 0.0003751 0.003106
563 NEGATIVE REGULATION OF RESPONSE TO CYTOKINE STIMULUS 12 44 0.0003784 0.003128
564 REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 24 127 0.0003792 0.003128
565 ODONTOGENESIS 21 105 0.0003903 0.003214
566 CELL GROWTH 25 135 0.0003991 0.003281
567 AMINOGLYCAN METABOLIC PROCESS 29 166 0.0004002 0.003283
568 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 9 27 0.0004007 0.003283
569 CYTOKINE PRODUCTION 23 120 0.0004029 0.003295
570 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 20 98 0.0004036 0.003295
571 REGULATION OF DEFENSE RESPONSE 96 759 0.0004076 0.003316
572 SENSORY ORGAN MORPHOGENESIS 38 239 0.0004069 0.003316
573 ENSHEATHMENT OF NEURONS 19 91 0.0004127 0.00334
574 AXON ENSHEATHMENT 19 91 0.0004127 0.00334
575 REGULATION OF CALCINEURIN NFAT SIGNALING CASCADE 7 17 0.0004114 0.00334
576 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 18 84 0.0004162 0.003362
577 MUSCLE CELL DEVELOPMENT 24 128 0.0004275 0.003448
578 DEFENSE RESPONSE 145 1231 0.0004298 0.003449
579 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 8 22 0.0004314 0.003449
580 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 8 22 0.0004314 0.003449
581 CELLULAR RESPONSE TO INTERLEUKIN 6 8 22 0.0004314 0.003449
582 AORTA MORPHOGENESIS 8 22 0.0004314 0.003449
583 REGULATION OF JNK CASCADE 28 159 0.0004372 0.003489
584 REGULATION OF GLUCOSE METABOLIC PROCESS 21 106 0.0004461 0.003554
585 REGULATION OF NEUROTRANSMITTER SECRETION 13 51 0.0004503 0.003575
586 REGULATION OF PHOSPHOLIPASE ACTIVITY 15 64 0.0004518 0.003575
587 REGULATION OF NEUROTRANSMITTER TRANSPORT 15 64 0.0004518 0.003575
588 REGULATION OF INTERLEUKIN 12 PRODUCTION 13 51 0.0004503 0.003575
589 POSITIVE REGULATION OF FATTY ACID METABOLIC PROCESS 10 33 0.0004593 0.003628
590 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 12 45 0.0004742 0.00374
591 REGULATION OF PHOSPHOLIPASE C ACTIVITY 11 39 0.0004803 0.003769
592 LONG TERM SYNAPTIC POTENTIATION 11 39 0.0004803 0.003769
593 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 34 208 0.0004802 0.003769
594 LYMPHOCYTE COSTIMULATION 17 78 0.0004839 0.003787
595 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 18 85 0.0004843 0.003787
596 REGULATION OF NEURON APOPTOTIC PROCESS 32 192 0.0004908 0.003832
597 REGULATION OF IMMUNE RESPONSE 106 858 0.0004931 0.003843
598 CIRCADIAN RHYTHM 25 137 0.0005018 0.003905
599 PLATELET DEGRANULATION 21 107 0.0005087 0.003952
600 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 6 13 0.0005216 0.004038
601 CEREBELLAR GRANULAR LAYER DEVELOPMENT 6 13 0.0005216 0.004038
602 EXOCYTOSIS 46 310 0.0005265 0.004069
603 ACTIN FILAMENT BASED MOVEMENT 19 93 0.0005496 0.004241
604 REGULATION OF HEART RATE 18 86 0.0005617 0.004327
605 POSITIVE REGULATION OF CELL CELL ADHESION 38 243 0.0005658 0.004344
606 BONE MORPHOGENESIS 17 79 0.0005656 0.004344
607 MULTICELLULAR ORGANISMAL SIGNALING 23 123 0.00058 0.004446
608 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 12 46 0.0005896 0.004512
609 REGULATION OF VESICLE MEDIATED TRANSPORT 63 462 0.0005935 0.004535
610 LUNG EPITHELIUM DEVELOPMENT 10 34 0.0005986 0.004551
611 HEART VALVE DEVELOPMENT 10 34 0.0005986 0.004551
612 CAMP METABOLIC PROCESS 10 34 0.0005986 0.004551
613 MAMMARY GLAND MORPHOGENESIS 11 40 0.0006092 0.004596
614 VASCULOGENESIS 14 59 0.0006063 0.004596
615 TRABECULA FORMATION 8 23 0.0006095 0.004596
616 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 11 40 0.0006092 0.004596
617 STRIATED MUSCLE ADAPTATION 8 23 0.0006095 0.004596
618 QUATERNARY AMMONIUM GROUP TRANSPORT 7 18 0.0006211 0.004661
619 RESPONSE TO CAFFEINE 7 18 0.0006211 0.004661
620 CENTROSOME LOCALIZATION 7 18 0.0006211 0.004661
621 RESPONSE TO ORGANOPHOSPHORUS 25 139 0.0006271 0.004698
622 REGULATION OF CARDIAC CONDUCTION 15 66 0.0006405 0.004791
623 ENDOCYTOSIS 68 509 0.0006501 0.004856
624 HIPPOCAMPUS DEVELOPMENT 16 73 0.0006569 0.004898
625 CELLULAR LIPID METABOLIC PROCESS 111 913 0.0006601 0.004914
626 B CELL ACTIVATION 24 132 0.0006791 0.005048
627 RENAL SYSTEM PROCESS 20 102 0.0006927 0.005141
628 MAMMARY GLAND DEVELOPMENT 22 117 0.0006989 0.005179
629 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 27 156 0.0007228 0.005347
630 REGULATION OF GLUCOSE IMPORT 14 60 0.0007262 0.005355
631 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 9 29 0.0007258 0.005355
632 REGULATION OF CYTOSKELETON ORGANIZATION 67 502 0.0007282 0.005361
633 STEROID HORMONE MEDIATED SIGNALING PATHWAY 23 125 0.0007328 0.005387
634 APOPTOTIC SIGNALING PATHWAY 43 289 0.0007426 0.00545
635 FORMATION OF PRIMARY GERM LAYER 21 110 0.0007446 0.005456
636 NEGATIVE REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 11 41 0.0007656 0.005592
637 CELL SUBSTRATE JUNCTION ASSEMBLY 11 41 0.0007656 0.005592
638 REGULATION OF DENDRITE MORPHOGENESIS 16 74 0.0007691 0.005609
639 REGULATION OF LEUKOCYTE MIGRATION 26 149 0.0007919 0.005767
640 REGULATION OF PEPTIDE TRANSPORT 39 256 0.00081 0.005889
641 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 14 0.0008434 0.006084
642 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 21 111 0.0008418 0.006084
643 REGULATION OF ANOIKIS 8 24 0.0008426 0.006084
644 POSITIVE REGULATION OF CELL SIZE 6 14 0.0008434 0.006084
645 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 8 24 0.0008426 0.006084
646 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 18 89 0.0008612 0.006203
647 RESPONSE TO KETONE 30 182 0.0008708 0.006263
648 HORMONE MEDIATED SIGNALING PATHWAY 27 158 0.0008832 0.006342
649 CELL MATRIX ADHESION 22 119 0.0008853 0.006347
650 REGULATION OF LIPID KINASE ACTIVITY 12 48 0.0008917 0.006383
651 RESPONSE TO CAMP 20 104 0.0008946 0.006385
652 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 20 104 0.0008946 0.006385
653 CELLULAR GLUCOSE HOMEOSTASIS 16 75 0.0008973 0.006394
654 POSITIVE REGULATION OF MAP KINASE ACTIVITY 33 207 0.0009008 0.006409
655 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 7 19 0.0009073 0.006426
656 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 7 19 0.0009073 0.006426
657 ASTROCYTE DEVELOPMENT 7 19 0.0009073 0.006426
658 CELLULAR MACROMOLECULE LOCALIZATION 143 1234 0.0009277 0.00655
659 REGULATED EXOCYTOSIS 35 224 0.0009273 0.00655
660 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 24 135 0.0009443 0.006658
661 SMOOTH MUSCLE CELL DIFFERENTIATION 9 30 0.0009548 0.006661
662 NEURON MATURATION 9 30 0.0009548 0.006661
663 CEREBELLAR CORTEX MORPHOGENESIS 9 30 0.0009548 0.006661
664 BLASTOCYST FORMATION 9 30 0.0009548 0.006661
665 POSITIVE REGULATION OF DNA BINDING 11 42 0.0009538 0.006661
666 MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 9 30 0.0009548 0.006661
667 POSITIVE REGULATION OF GLUCOSE TRANSPORT 11 42 0.0009538 0.006661
668 GLIOGENESIS 29 175 0.000965 0.006722
669 PROTEIN LOCALIZATION TO CELL PERIPHERY 26 151 0.0009711 0.006754
670 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 10 36 0.0009825 0.006823
671 REGULATION OF OXIDOREDUCTASE ACTIVITY 18 90 0.0009874 0.006827
672 CALCIUM MEDIATED SIGNALING 18 90 0.0009874 0.006827
673 REGULATION OF CELL MATRIX ADHESION 18 90 0.0009874 0.006827
674 REGULATION OF TISSUE REMODELING 14 62 0.001027 0.007088
675 REGULATION OF CALCIUM MEDIATED SIGNALING 16 76 0.001043 0.00718
676 MULTICELLULAR ORGANISM GROWTH 16 76 0.001043 0.00718
677 SYNAPSE ASSEMBLY 15 69 0.001047 0.007193
678 RESPONSE TO CORTICOSTEROID 29 176 0.001058 0.007262
679 REGULATION OF CALCIUM ION TRANSPORT 33 209 0.001066 0.007282
680 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 25 144 0.001066 0.007282
681 REGULATION OF PEPTIDE SECRETION 33 209 0.001066 0.007282
682 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 26 152 0.001073 0.007322
683 CARDIAC SEPTUM MORPHOGENESIS 12 49 0.001085 0.007394
684 REGULATION OF ION HOMEOSTASIS 32 201 0.001093 0.007436
685 RESPONSE TO ESTROGEN 34 218 0.001124 0.007632
686 LUNG CELL DIFFERENTIATION 8 25 0.001142 0.007735
687 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 25 0.001142 0.007735
688 REGULATION OF DENDRITIC SPINE DEVELOPMENT 13 56 0.001169 0.007896
689 OUTFLOW TRACT MORPHOGENESIS 13 56 0.001169 0.007896
690 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 17 84 0.001175 0.007926
691 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 11 43 0.001179 0.007937
692 REGULATION OF OSTEOCLAST DIFFERENTIATION 14 63 0.001212 0.008152
693 CORONARY VASCULATURE DEVELOPMENT 10 37 0.001239 0.00826
694 POSITIVE REGULATION OF B CELL PROLIFERATION 10 37 0.001239 0.00826
695 RESPONSE TO NERVE GROWTH FACTOR 10 37 0.001239 0.00826
696 MYOBLAST DIFFERENTIATION 10 37 0.001239 0.00826
697 REGULATION OF PROTEIN AUTOPHOSPHORYLATION 10 37 0.001239 0.00826
698 REGULATION OF SYNAPTIC VESICLE TRANSPORT 9 31 0.001239 0.00826
699 PEPTIDYL TYROSINE MODIFICATION 30 186 0.001245 0.008288
700 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 33 211 0.001256 0.008348
701 EMBRYONIC HEMOPOIESIS 7 20 0.001288 0.008502
702 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 7 20 0.001288 0.008502
703 CELLULAR RESPONSE TO CYTOKINE STIMULUS 77 606 0.001287 0.008502
704 INTRACELLULAR LIPID TRANSPORT 7 20 0.001288 0.008502
705 LYMPH VESSEL DEVELOPMENT 7 20 0.001288 0.008502
706 CELL CHEMOTAXIS 27 162 0.001299 0.008525
707 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 6 15 0.001299 0.008525
708 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 6 15 0.001299 0.008525
709 T CELL LINEAGE COMMITMENT 6 15 0.001299 0.008525
710 PALATE DEVELOPMENT 17 85 0.001348 0.008835
711 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 19 100 0.00138 0.00902
712 LIMBIC SYSTEM DEVELOPMENT 19 100 0.00138 0.00902
713 CIRCADIAN REGULATION OF GENE EXPRESSION 13 57 0.001392 0.009082
714 REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 28 171 0.001409 0.009167
715 REGULATION OF RESPONSE TO NUTRIENT LEVELS 28 171 0.001409 0.009167
716 REGULATION OF MUSCLE CONTRACTION 25 147 0.00144 0.009359
717 MYELOID CELL DEVELOPMENT 11 44 0.001445 0.009381
718 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 20 108 0.001454 0.00942
719 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 18 93 0.001465 0.009454
720 NEPHRON EPITHELIUM DEVELOPMENT 18 93 0.001465 0.009454
721 POSITIVE REGULATION OF BLOOD CIRCULATION 18 93 0.001465 0.009454
722 HEART TRABECULA MORPHOGENESIS 8 26 0.001521 0.009773
723 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 8 26 0.001521 0.009773
724 RESPONSE TO INTERLEUKIN 6 8 26 0.001521 0.009773
725 MESENCHYME MORPHOGENESIS 10 38 0.001547 0.009918
726 POSITIVE REGULATION OF ORGAN GROWTH 10 38 0.001547 0.009918
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 160 842 2.458e-20 2.284e-17
2 PROTEIN KINASE ACTIVITY 126 640 1.846e-17 8.576e-15
3 ENZYME BINDING 253 1737 1.788e-15 5.537e-13
4 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 164 992 6.908e-15 1.604e-12
5 MOLECULAR FUNCTION REGULATOR 205 1353 2.476e-14 4.6e-12
6 PROTEIN SERINE THREONINE KINASE ACTIVITY 89 445 4.402e-13 6.816e-11
7 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 72 328 7.561e-13 1.003e-10
8 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 111 629 3.215e-12 3.734e-10
9 MACROMOLECULAR COMPLEX BINDING 201 1399 7.706e-12 7.954e-10
10 PROTEIN COMPLEX BINDING 145 935 3.9e-11 3.623e-09
11 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 66 315 5.944e-11 4.654e-09
12 RECEPTOR BINDING 206 1476 6.011e-11 4.654e-09
13 CYTOSKELETAL PROTEIN BINDING 130 819 8.907e-11 6.365e-09
14 PROTEIN DOMAIN SPECIFIC BINDING 105 624 2.231e-10 1.48e-08
15 TRANSCRIPTION FACTOR BINDING 92 524 3.178e-10 1.969e-08
16 PHOSPHATIDYLINOSITOL BINDING 47 200 6.781e-10 3.937e-08
17 ACTIN BINDING 73 393 1.82e-09 9.943e-08
18 CYTOKINE BINDING 28 92 4.683e-09 2.29e-07
19 REGULATORY REGION NUCLEIC ACID BINDING 124 818 4.453e-09 2.29e-07
20 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 49 226 5.306e-09 2.465e-07
21 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 166 1199 9.346e-09 4.135e-07
22 CALCIUM ION BINDING 107 697 2.7e-08 1.14e-06
23 IDENTICAL PROTEIN BINDING 165 1209 2.83e-08 1.143e-06
24 DOUBLE STRANDED DNA BINDING 113 764 8.407e-08 3.254e-06
25 ENZYME REGULATOR ACTIVITY 135 959 9.29e-08 3.452e-06
26 GROWTH FACTOR BINDING 31 123 9.769e-08 3.49e-06
27 CELL ADHESION MOLECULE BINDING 40 186 1.656e-07 5.698e-06
28 SMAD BINDING 22 72 1.903e-07 6.315e-06
29 KINASE BINDING 93 606 2.25e-07 6.967e-06
30 PHOSPHOLIPID BINDING 63 360 2.232e-07 6.967e-06
31 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 55 303 3.886e-07 1.165e-05
32 CALMODULIN BINDING 38 179 4.721e-07 1.37e-05
33 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 58 329 5.195e-07 1.462e-05
34 SEQUENCE SPECIFIC DNA BINDING 140 1037 6.321e-07 1.727e-05
35 CORE PROMOTER PROXIMAL REGION DNA BINDING 63 371 6.625e-07 1.758e-05
36 BETA CATENIN BINDING 23 84 8.965e-07 2.251e-05
37 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 24 90 8.848e-07 2.251e-05
38 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 44 228 1.013e-06 2.477e-05
39 LIPID BINDING 96 657 1.379e-06 3.286e-05
40 RIBONUCLEOTIDE BINDING 225 1860 1.62e-06 3.762e-05
41 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 22 81 1.786e-06 3.951e-05
42 PROTEIN HOMODIMERIZATION ACTIVITY 103 722 1.749e-06 3.951e-05
43 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 20 70 2.207e-06 4.769e-05
44 TRANSFORMING GROWTH FACTOR BETA BINDING 9 16 2.443e-06 5.157e-05
45 ENZYME ACTIVATOR ACTIVITY 73 471 3.097e-06 6.394e-05
46 RECEPTOR SIGNALING PROTEIN ACTIVITY 35 172 3.655e-06 7.322e-05
47 ADENYL NUCLEOTIDE BINDING 187 1514 3.704e-06 7.322e-05
48 CORE PROMOTER BINDING 32 152 4.445e-06 8.604e-05
49 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BINDING 12 31 7.644e-06 0.0001449
50 BHLH TRANSCRIPTION FACTOR BINDING 11 28 1.557e-05 0.0002893
51 INTEGRIN BINDING 24 105 1.608e-05 0.0002929
52 PHOSPHATASE BINDING 32 162 1.772e-05 0.0003165
53 SIGNALING ADAPTOR ACTIVITY 19 74 2.14e-05 0.0003751
54 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 83 588 2.585e-05 0.0004367
55 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 23 101 2.554e-05 0.0004367
56 BINDING BRIDGING 33 173 2.79e-05 0.0004629
57 ACTIVATING TRANSCRIPTION FACTOR BINDING 16 57 2.869e-05 0.0004676
58 GLYCOSAMINOGLYCAN BINDING 37 205 3.358e-05 0.0005379
59 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 32 168 3.775e-05 0.0005943
60 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 8 17 4.943e-05 0.0007653
61 INSULIN RECEPTOR BINDING 11 32 6.669e-05 0.001016
62 PROTEIN COMPLEX SCAFFOLD 17 68 8.234e-05 0.001232
63 PROTEIN DIMERIZATION ACTIVITY 141 1149 8.353e-05 0.001232
64 PHOSPHATIDYLINOSITOL PHOSPHATE BINDING 24 116 8.929e-05 0.001296
65 UBIQUITIN LIKE PROTEIN LIGASE BINDING 43 264 0.0001013 0.001448
66 TRANSCRIPTION COFACTOR BINDING 9 24 0.0001433 0.001987
67 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 105 0.0001422 0.001987
68 HEPARIN BINDING 29 157 0.00015 0.00205
69 TRANSCRIPTION COACTIVATOR BINDING 6 11 0.0001646 0.002153
70 INSULIN LIKE GROWTH FACTOR RECEPTOR BINDING 7 15 0.00016 0.002153
71 PLATELET DERIVED GROWTH FACTOR BINDING 6 11 0.0001646 0.002153
72 CYTOKINE RECEPTOR BINDING 43 271 0.0001845 0.00238
73 SH3 DOMAIN BINDING 23 116 0.0002412 0.003037
74 PHOSPHORIC ESTER HYDROLASE ACTIVITY 54 368 0.0002419 0.003037
75 CHANNEL REGULATOR ACTIVITY 25 131 0.0002474 0.003064
76 PROTEIN C TERMINUS BINDING 32 186 0.0002751 0.003362
77 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 25 133 0.0003153 0.003803
78 PROTEASE BINDING 21 104 0.0003407 0.004058
79 PDZ DOMAIN BINDING 19 90 0.0003562 0.004188
80 PROTEIN SELF ASSOCIATION 12 44 0.0003784 0.004394
81 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 19 92 0.0004769 0.00547
82 HISTONE ACETYLTRANSFERASE BINDING 9 28 0.0005437 0.006159
83 CATION CHANNEL ACTIVITY 44 298 0.0007631 0.008542
84 GLUCOCORTICOID RECEPTOR BINDING 6 14 0.0008434 0.009327
85 VOLTAGE GATED ION CHANNEL ACTIVITY 31 190 0.000859 0.009389
86 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 12 48 0.0008917 0.009632
87 ADRENERGIC RECEPTOR BINDING 7 19 0.0009073 0.009689
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 167 942 4.546e-18 2.655e-15
2 CELL JUNCTION 191 1151 2.151e-17 6.28e-15
3 CELL PROJECTION 263 1786 1.099e-16 2.139e-14
4 NEURON PART 202 1265 1.621e-16 2.367e-14
5 SYNAPSE 136 754 1.716e-15 2.004e-13
6 ANCHORING JUNCTION 95 489 4.308e-13 4.193e-11
7 INTRACELLULAR VESICLE 188 1259 1.288e-12 1.074e-10
8 EXCITATORY SYNAPSE 51 197 2.737e-12 1.998e-10
9 CELL LEADING EDGE 73 350 7.2e-12 4.672e-10
10 INTRINSIC COMPONENT OF PLASMA MEMBRANE 224 1649 1.048e-10 6.118e-09
11 POSTSYNAPSE 74 378 1.193e-10 6.332e-09
12 MEMBRANE REGION 166 1134 1.463e-10 7.119e-09
13 CELL SUBSTRATE JUNCTION 76 398 2.261e-10 1.015e-08
14 CELL SURFACE 121 757 2.64e-10 1.101e-08
15 PLASMA MEMBRANE PROTEIN COMPLEX 90 510 3.792e-10 1.476e-08
16 SIDE OF MEMBRANE 78 428 1.263e-09 4.337e-08
17 SYNAPSE PART 101 610 1.224e-09 4.337e-08
18 AXON 75 418 5.312e-09 1.724e-07
19 ACTIN CYTOSKELETON 78 444 6.969e-09 2.142e-07
20 VACUOLE 164 1180 8.814e-09 2.574e-07
21 SOMATODENDRITIC COMPARTMENT 102 650 1.849e-08 5.142e-07
22 MAIN AXON 20 58 7.236e-08 1.921e-06
23 PLASMA MEMBRANE REGION 131 929 1.316e-07 3.341e-06
24 CELL PROJECTION PART 132 946 2.154e-07 5.08e-06
25 EXTERNAL SIDE OF PLASMA MEMBRANE 47 238 2.175e-07 5.08e-06
26 ACTOMYOSIN 20 62 2.536e-07 5.696e-06
27 MEMBRANE MICRODOMAIN 53 288 4.031e-07 8.718e-06
28 NEURONAL POSTSYNAPTIC DENSITY 18 53 4.208e-07 8.776e-06
29 CYTOPLASMIC VESICLE PART 91 601 5.548e-07 1.117e-05
30 PROTEINACEOUS EXTRACELLULAR MATRIX 61 356 7.262e-07 1.414e-05
31 CELL CELL JUNCTION 64 383 9.626e-07 1.757e-05
32 GOLGI APPARATUS 183 1445 9.571e-07 1.757e-05
33 EXTRACELLULAR MATRIX 69 426 1.181e-06 2.074e-05
34 DENDRITE 72 451 1.207e-06 2.074e-05
35 RECEPTOR COMPLEX 56 327 2.078e-06 3.468e-05
36 CYTOSKELETON 234 1967 3.382e-06 5.486e-05
37 LAMELLIPODIUM 35 172 3.655e-06 5.77e-05
38 ENDOCYTIC VESICLE 46 256 4.482e-06 6.888e-05
39 VESICLE MEMBRANE 77 512 5.265e-06 7.32e-05
40 CATION CHANNEL COMPLEX 34 167 4.945e-06 7.32e-05
41 AXON PART 41 219 5.152e-06 7.32e-05
42 ENDOSOME 109 793 5.047e-06 7.32e-05
43 SARCOPLASM 19 68 5.658e-06 7.684e-05
44 BASAL PART OF CELL 16 51 5.981e-06 7.938e-05
45 EXTRINSIC COMPONENT OF MEMBRANE 45 252 6.703e-06 8.699e-05
46 CYTOPLASMIC REGION 49 287 9.605e-06 0.0001219
47 CONTRACTILE FIBER 39 211 1.182e-05 0.0001469
48 COMPLEX OF COLLAGEN TRIMERS 10 23 1.312e-05 0.0001597
49 CELL CORTEX 42 238 1.801e-05 0.0002146
50 I BAND 26 121 2.328e-05 0.0002719
51 EARLY ENDOSOME 48 301 7.096e-05 0.0008126
52 PLASMA MEMBRANE RECEPTOR COMPLEX 32 175 8.57e-05 0.0009625
53 EXTRACELLULAR SPACE 164 1376 0.0001011 0.001114
54 EXTRACELLULAR MATRIX COMPONENT 25 125 0.0001144 0.001238
55 CELL CORTEX PART 24 119 0.0001357 0.001441
56 CELL BODY 69 494 0.0001657 0.001698
57 ACTIN BASED CELL PROJECTION 32 181 0.0001648 0.001698
58 APICAL JUNCTION COMPLEX 25 128 0.0001697 0.001708
59 NEURON SPINE 24 121 0.0001775 0.001757
60 AUTOPHAGOSOME 18 79 0.0001858 0.001809
61 SECRETORY VESICLE 65 461 0.0001935 0.001823
62 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 10 30 0.0001915 0.001823
63 ENDOCYTIC VESICLE MEMBRANE 28 152 0.0002028 0.00188
64 FILOPODIUM 20 94 0.0002258 0.002028
65 LYTIC VACUOLE 72 526 0.0002241 0.002028
66 ENDOPLASMIC RETICULUM LUMEN 34 201 0.0002509 0.00222
67 CORTICAL CYTOSKELETON 18 81 0.0002592 0.002258
68 COLLAGEN TRIMER 19 88 0.0002629 0.002258
69 APICAL PART OF CELL 53 361 0.0002714 0.002297
70 PARANODE REGION OF AXON 6 12 0.000304 0.002466
71 BANDED COLLAGEN FIBRIL 6 12 0.000304 0.002466
72 SARCOLEMMA 24 125 0.0002966 0.002466
73 RUFFLE 28 156 0.0003172 0.002516
74 SYNAPTIC MEMBRANE 41 261 0.0003188 0.002516
75 MEMBRANE PROTEIN COMPLEX 124 1020 0.0003266 0.002543
76 PROTEIN KINASE COMPLEX 19 90 0.0003562 0.002701
77 POTASSIUM CHANNEL COMPLEX 19 90 0.0003562 0.002701
78 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 20 98 0.0004036 0.003022
79 ACTIN FILAMENT BUNDLE 14 57 0.0004161 0.003038
80 MICROTUBULE PLUS END 7 17 0.0004114 0.003038
81 PERINUCLEAR REGION OF CYTOPLASM 83 642 0.0005022 0.00362
82 PLASMA MEMBRANE RAFT 18 86 0.0005617 0.004
83 FILOPODIUM MEMBRANE 7 18 0.0006211 0.004318
84 TRANSPORTER COMPLEX 47 321 0.0006209 0.004318
85 ENDOPLASMIC RETICULUM 184 1631 0.0006723 0.004619
86 LEADING EDGE MEMBRANE 24 134 0.0008474 0.005688
87 VOLTAGE GATED SODIUM CHANNEL COMPLEX 6 14 0.0008434 0.005688
88 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 24 136 0.001051 0.006973
89 EARLY ENDOSOME MEMBRANE 21 113 0.001069 0.007018
90 ACTIN FILAMENT 15 70 0.001223 0.007936
91 BASOLATERAL PLASMA MEMBRANE 33 211 0.001256 0.00806
92 CYTOPLASMIC SIDE OF MEMBRANE 28 170 0.001286 0.008089
93 FILAMENTOUS ACTIN 7 20 0.001288 0.008089
94 GOLGI APPARATUS PART 107 893 0.001347 0.008366
95 VACUOLAR PART 86 694 0.001476 0.009075
96 POSTSYNAPTIC MEMBRANE 32 205 0.001523 0.009264
97 PHAGOCYTIC VESICLE 17 86 0.001542 0.009284
98 PRESYNAPSE 41 283 0.001633 0.009733
99 APICAL PLASMA MEMBRANE 42 292 0.001662 0.009803

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 51 199 4.141e-12 2.153e-10
2 TNF_signaling_pathway_hsa04668 33 108 1.797e-10 4.673e-09
3 MAPK_signaling_pathway_hsa04010 61 295 5.474e-10 9.488e-09
4 FoxO_signaling_pathway_hsa04068 34 132 1.321e-08 1.718e-07
5 cGMP_PKG_signaling_pathway_hsa04022 38 163 3.581e-08 3.605e-07
6 PI3K_Akt_signaling_pathway_hsa04151 64 352 4.185e-08 3.605e-07
7 Cell_adhesion_molecules_.CAMs._hsa04514 35 145 4.853e-08 3.605e-07
8 Rap1_signaling_pathway_hsa04015 42 206 3.856e-07 2.506e-06
9 AMPK_signaling_pathway_hsa04152 29 121 7.811e-07 4.513e-06
10 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 31 139 1.745e-06 8.579e-06
11 Cellular_senescence_hsa04218 34 160 1.815e-06 8.579e-06
12 cAMP_signaling_pathway_hsa04024 39 198 2.428e-06 1.052e-05
13 Apelin_signaling_pathway_hsa04371 30 137 3.789e-06 1.516e-05
14 Regulation_of_actin_cytoskeleton_hsa04810 39 208 8.344e-06 3.099e-05
15 TGF_beta_signaling_pathway_hsa04350 21 84 1.255e-05 4.352e-05
16 Hippo_signaling_pathway_hsa04390 31 154 1.611e-05 5.236e-05
17 Hippo_signaling_pathway_multiple_species_hsa04392 11 29 2.305e-05 7.05e-05
18 Ras_signaling_pathway_hsa04014 40 232 4.858e-05 0.0001403
19 Phosphatidylinositol_signaling_system_hsa04070 22 99 5.643e-05 0.0001544
20 Autophagy_animal_hsa04140 26 128 6.425e-05 0.000167
21 Sphingolipid_signaling_pathway_hsa04071 24 118 0.0001183 0.0002929
22 Calcium_signaling_pathway_hsa04020 32 182 0.000183 0.0004324
23 Phospholipase_D_signaling_pathway_hsa04072 27 146 0.0002445 0.0005528
24 ECM_receptor_interaction_hsa04512 18 82 0.0003045 0.0006598
25 mTOR_signaling_pathway_hsa04150 27 151 0.0004278 0.0008899
26 HIF_1_signaling_pathway_hsa04066 20 100 0.0005313 0.001063
27 Apoptosis_hsa04210 25 138 0.0005614 0.001081
28 Endocytosis_hsa04144 38 244 0.0006132 0.001139
29 Tight_junction_hsa04530 28 170 0.001286 0.002306
30 ErbB_signaling_pathway_hsa04012 17 85 0.001348 0.002337
31 NF_kappa_B_signaling_pathway_hsa04064 18 95 0.001882 0.003156
32 Cytokine_cytokine_receptor_interaction_hsa04060 39 270 0.002205 0.003584
33 Adherens_junction_hsa04520 14 72 0.004517 0.007118
34 Phagosome_hsa04145 24 152 0.004782 0.007313
35 Jak_STAT_signaling_pathway_hsa04630 24 162 0.0105 0.0156
36 Wnt_signaling_pathway_hsa04310 22 146 0.01148 0.01658
37 Mitophagy_animal_hsa04137 12 65 0.01242 0.01746
38 Oocyte_meiosis_hsa04114 19 124 0.01519 0.02078
39 p53_signaling_pathway_hsa04115 12 68 0.01751 0.02335
40 Gap_junction_hsa04540 13 88 0.05128 0.06666
41 Notch_signaling_pathway_hsa04330 7 48 0.1372 0.174
42 Necroptosis_hsa04217 19 164 0.1538 0.1874
43 Autophagy_other_hsa04136 5 32 0.1566 0.1874
44 VEGF_signaling_pathway_hsa04370 8 59 0.1585 0.1874
45 Lysosome_hsa04142 14 123 0.2171 0.2508
46 Hedgehog_signaling_pathway_hsa04340 6 47 0.2462 0.2783
47 Apoptosis_multiple_species_hsa04215 4 33 0.3463 0.3831
48 Cell_cycle_hsa04110 12 124 0.4422 0.4791
49 ABC_transporters_hsa02010 4 45 0.587 0.6229
50 Ferroptosis_hsa04216 3 40 0.7116 0.7401
51 Peroxisome_hsa04146 4 83 0.9483 0.9669
52 Neuroactive_ligand_receptor_interaction_hsa04080 16 278 0.983 0.983

Quest ID: aca2b0cf1e316819c4dfd01c9ed5f83d