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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-20a-5p ABCA1 3.16 0 -0.71 0.00276 MirTarget; miRNATAP -0.18 0 NA
2 hsa-miR-20a-5p ABCA3 3.16 0 -1.39 0.0022 miRNAWalker2 validate -0.24 0.00039 NA
3 hsa-miR-20a-5p ABCD2 3.16 0 -3.08 0 MirTarget -0.58 0 NA
4 hsa-miR-20a-5p ABHD2 3.16 0 -0.37 0.12248 miRNATAP -0.11 0.00278 NA
5 hsa-miR-20a-5p ADAM19 3.16 0 -1.06 0.01895 mirMAP -0.38 0 NA
6 hsa-miR-20a-5p ADAM9 3.16 0 -0.2 0.40665 miRNATAP -0.19 0 NA
7 hsa-miR-20a-5p ADAMTS5 3.16 0 -2.16 0 miRNATAP -0.38 0 NA
8 hsa-miR-20a-5p ADARB1 3.16 0 -1.93 0 MirTarget -0.36 0 NA
9 hsa-miR-20a-5p ADCY9 3.16 0 -1.5 0 mirMAP -0.32 0 NA
10 hsa-miR-20a-5p ADRA2A 3.16 0 -2.58 0 miRNATAP -0.58 0 NA
11 hsa-miR-20a-5p AFF4 3.16 0 -0.82 0 miRNATAP -0.13 0 NA
12 hsa-miR-20a-5p AGFG2 3.16 0 -0.51 0.00539 miRNATAP -0.11 4.0E-5 NA
13 hsa-miR-20a-5p AHNAK 3.16 0 -1.66 0 miRNATAP -0.34 0 NA
14 hsa-miR-20a-5p AKAP13 3.16 0 -1.15 0 MirTarget; mirMAP; miRNATAP -0.25 0 NA
15 hsa-miR-20a-5p AKT3 3.16 0 -1.94 0 miRNATAP -0.4 0 NA
16 hsa-miR-20a-5p AKTIP 3.16 0 -0.35 0.01135 MirTarget; miRNATAP -0.13 0 NA
17 hsa-miR-20a-5p ALDH1A3 3.16 0 -1.34 0.0022 mirMAP -0.32 0 NA
18 hsa-miR-20a-5p ALPK3 3.16 0 -1.02 0.00049 mirMAP -0.3 0 NA
19 hsa-miR-20a-5p ANK2 3.16 0 -4.32 0 MirTarget; miRNATAP -0.74 0 NA
20 hsa-miR-20a-5p ANKH 3.16 0 -0.38 0.21654 MirTarget -0.23 0 NA
21 hsa-miR-20a-5p ANKRD12 3.16 0 -0.64 0.00012 MirTarget -0.11 1.0E-5 NA
22 hsa-miR-20a-5p ANKRD29 3.16 0 -3.47 0 MirTarget -0.68 0 NA
23 hsa-miR-20a-5p ANKRD50 3.16 0 -0.88 0.00174 MirTarget; miRNATAP -0.17 5.0E-5 NA
24 hsa-miR-20a-5p ANO6 3.16 0 -0.74 3.0E-5 MirTarget -0.16 0 NA
25 hsa-miR-20a-5p APBB2 3.16 0 -0.59 0.0014 MirTarget; miRNATAP -0.2 0 NA
26 hsa-miR-20a-5p APCDD1 3.16 0 -1.6 0 MirTarget -0.19 0.00033 NA
27 hsa-miR-20a-5p APP 3.16 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.18 0 20458444 miR 20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells; Furthermore suppression of APP expression could also promote ovarian cancer cell proliferation and invasion which is consistent with the results of miR-20a overexpression; Therefore we concluded that the regulation of APP is an important mechanism for miR-20a to promote proliferation and invasion in ovarian cancer cells
28 hsa-miR-20a-5p AR 3.16 0 -3.3 0 mirMAP -0.52 0 NA
29 hsa-miR-20a-5p ARHGAP1 3.16 0 -0.88 0 MirTarget; miRNATAP -0.22 0 NA
30 hsa-miR-20a-5p ARHGAP24 3.16 0 -2.02 0 MirTarget -0.45 0 NA
31 hsa-miR-20a-5p ARHGAP26 3.16 0 -0.72 0.00357 MirTarget; mirMAP; miRNATAP -0.1 0.00713 NA
32 hsa-miR-20a-5p ARHGEF3 3.16 0 -0.76 0 MirTarget; miRNATAP -0.17 0 NA
33 hsa-miR-20a-5p ARID4A 3.16 0 -0.76 0 MirTarget; miRNATAP -0.1 0 NA
34 hsa-miR-20a-5p ARL10 3.16 0 -1.12 0.00198 mirMAP -0.2 0.00018 NA
35 hsa-miR-20a-5p ARL4C 3.16 0 -0.28 0.33535 MirTarget; miRNATAP -0.2 0 NA
36 hsa-miR-20a-5p ARNT2 3.16 0 -1.45 0.00019 mirMAP -0.18 0.00281 NA
37 hsa-miR-20a-5p ARSB 3.16 0 -0.58 0.00052 mirMAP -0.22 0 NA
38 hsa-miR-20a-5p ASH1L 3.16 0 -0.67 0.00016 miRNATAP -0.13 0 NA
39 hsa-miR-20a-5p ASPA 3.16 0 -4.76 0 mirMAP -0.63 0 NA
40 hsa-miR-20a-5p ATE1 3.16 0 -1.09 3.0E-5 MirTarget -0.21 0 NA
41 hsa-miR-20a-5p ATP1A2 3.16 0 -6.96 0 MirTarget; miRNATAP -1.19 0 NA
42 hsa-miR-20a-5p ATP2A2 3.16 0 -0.4 0.01225 mirMAP -0.12 0 NA
43 hsa-miR-20a-5p ATP8B2 3.16 0 -1.89 0 miRNAWalker2 validate -0.41 0 NA
44 hsa-miR-20a-5p ATRX 3.16 0 -0.65 1.0E-5 mirMAP -0.12 0 NA
45 hsa-miR-20a-5p ATXN1 3.16 0 -1.51 0 miRNATAP -0.39 0 NA
46 hsa-miR-20a-5p ATXN1L 3.16 0 -0.47 0.0041 miRNATAP -0.11 1.0E-5 NA
47 hsa-miR-20a-5p B3GALT2 3.16 0 -3.85 0 MirTarget -0.49 0 NA
48 hsa-miR-20a-5p BBX 3.16 0 -0.51 0.00131 MirTarget; miRNATAP -0.12 0 NA
49 hsa-miR-20a-5p BCL2 3.16 0 -2.02 0 miRNAWalker2 validate; miRTarBase -0.27 0 NA
50 hsa-miR-20a-5p BCL2L2 3.16 0 -1.27 0 miRNATAP -0.15 0 NA
51 hsa-miR-20a-5p BCL6 3.16 0 -0.56 0.00743 miRNATAP -0.13 4.0E-5 NA
52 hsa-miR-20a-5p BCL9L 3.16 0 -0.07 0.6694 mirMAP -0.11 1.0E-5 NA
53 hsa-miR-20a-5p BEND4 3.16 0 -1.97 7.0E-5 mirMAP -0.24 0.00133 NA
54 hsa-miR-20a-5p BMP2 3.16 0 -1.46 0.00276 miRNATAP -0.17 0.01894 NA
55 hsa-miR-20a-5p BMPR2 3.16 0 -0.59 4.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.21 0 NA
56 hsa-miR-20a-5p BNC2 3.16 0 -2.95 0 miRNATAP -0.79 0 NA
57 hsa-miR-20a-5p BTG2 3.16 0 -2.39 0 miRNATAP -0.24 0 NA
58 hsa-miR-20a-5p C14orf28 3.16 0 -0.89 0 miRNATAP -0.15 0 NA
59 hsa-miR-20a-5p C3orf70 3.16 0 -2.6 0 miRNATAP -0.38 0 NA
60 hsa-miR-20a-5p C9orf47 3.16 0 -2.02 2.0E-5 mirMAP -0.27 0.0001 NA
61 hsa-miR-20a-5p CA5B 3.16 0 -1.09 0 mirMAP -0.17 0 NA
62 hsa-miR-20a-5p CADM2 3.16 0 -3.84 0 MirTarget; miRNATAP -0.31 0.00048 NA
63 hsa-miR-20a-5p CALD1 3.16 0 -2.47 0 miRNATAP -0.66 0 NA
64 hsa-miR-20a-5p CASC4 3.16 0 -0.27 0.06567 MirTarget -0.13 0 NA
65 hsa-miR-20a-5p CAV1 3.16 0 -2.02 0 miRNATAP -0.37 0 NA
66 hsa-miR-20a-5p CAV2 3.16 0 -0.86 0.01061 mirMAP -0.25 0 NA
67 hsa-miR-20a-5p CBX7 3.16 0 -2.55 0 mirMAP -0.36 0 NA
68 hsa-miR-20a-5p CCBE1 3.16 0 -1.07 0.09592 mirMAP -0.22 0.02013 NA
69 hsa-miR-20a-5p CCND2 3.16 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.55 0 NA
70 hsa-miR-20a-5p CD28 3.16 0 -1.38 0.00084 mirMAP -0.4 0 NA
71 hsa-miR-20a-5p CD69 3.16 0 -2.49 0 miRNATAP -0.45 0 NA
72 hsa-miR-20a-5p CDC37L1 3.16 0 -1.08 0 MirTarget; miRNATAP -0.13 0 NA
73 hsa-miR-20a-5p CDK6 3.16 0 -0.77 0.06479 mirMAP -0.19 0.00261 NA
74 hsa-miR-20a-5p CDKN1A 3.16 0 -1.29 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.17 7.0E-5 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex
75 hsa-miR-20a-5p CELF2 3.16 0 -3.05 0 miRNATAP -0.61 0 NA
76 hsa-miR-20a-5p CERCAM 3.16 0 0.21 0.50968 MirTarget -0.15 0.00239 NA
77 hsa-miR-20a-5p CERK 3.16 0 -1.14 9.0E-5 mirMAP -0.18 4.0E-5 NA
78 hsa-miR-20a-5p CFL2 3.16 0 -2.62 0 MirTarget; miRNATAP -0.44 0 NA
79 hsa-miR-20a-5p CHD5 3.16 0 -3.46 0 MirTarget; miRNATAP -0.27 7.0E-5 NA
80 hsa-miR-20a-5p CHD9 3.16 0 -0.8 1.0E-5 MirTarget; miRNATAP -0.17 0 NA
81 hsa-miR-20a-5p CIITA 3.16 0 -0.02 0.95968 mirMAP -0.15 0.02355 NA
82 hsa-miR-20a-5p CLDN16 3.16 0 0.26 0.60929 mirMAP -0.16 0.03344 NA
83 hsa-miR-20a-5p CLIP4 3.16 0 -1.61 0 MirTarget -0.37 0 NA
84 hsa-miR-20a-5p CLOCK 3.16 0 -0.51 0.03689 MirTarget -0.15 3.0E-5 NA
85 hsa-miR-20a-5p CLUAP1 3.16 0 -0.82 3.0E-5 mirMAP -0.11 0.00014 NA
86 hsa-miR-20a-5p CNR2 3.16 0 -2.05 6.0E-5 mirMAP -0.43 0 NA
87 hsa-miR-20a-5p COL1A1 3.16 0 -0.11 0.82007 mirMAP -0.49 0 NA
88 hsa-miR-20a-5p COL4A3 3.16 0 -3.14 0 MirTarget; miRNATAP -0.28 0.00343 NA
89 hsa-miR-20a-5p COL8A2 3.16 0 -1.27 0.00295 mirMAP -0.59 0 NA
90 hsa-miR-20a-5p CORO2B 3.16 0 -2.03 0 MirTarget; miRNATAP -0.34 0 NA
91 hsa-miR-20a-5p CPEB3 3.16 0 -1.3 0 miRNATAP -0.23 0 NA
92 hsa-miR-20a-5p CPEB4 3.16 0 -1.56 0 mirMAP -0.31 0 NA
93 hsa-miR-20a-5p CPT1A 3.16 0 -0.83 0.00093 mirMAP -0.22 0 NA
94 hsa-miR-20a-5p CREB3L2 3.16 0 -0.29 0.1662 mirMAP -0.19 0 NA
95 hsa-miR-20a-5p CREB5 3.16 0 -2.28 0 MirTarget; miRNATAP -0.35 0 NA
96 hsa-miR-20a-5p CRIM1 3.16 0 -0.45 0.0534 miRTarBase; MirTarget; miRNATAP -0.18 0 NA
97 hsa-miR-20a-5p CRY2 3.16 0 -1.68 0 MirTarget; miRNATAP -0.22 0 NA
98 hsa-miR-20a-5p CRYBG3 3.16 0 -1.11 5.0E-5 MirTarget; miRNATAP -0.31 0 NA
99 hsa-miR-20a-5p CSF1 3.16 0 -1.3 0.00033 miRNATAP -0.39 0 NA
100 hsa-miR-20a-5p CSGALNACT1 3.16 0 -2.42 0 MirTarget -0.37 0 NA
101 hsa-miR-20a-5p CTSK 3.16 0 -1.41 0.00081 MirTarget -0.55 0 NA
102 hsa-miR-20a-5p CXCL6 3.16 0 0.73 0.29922 MirTarget -0.24 0.0251 NA
103 hsa-miR-20a-5p CXorf36 3.16 0 -1.52 0 mirMAP -0.28 0 NA
104 hsa-miR-20a-5p CYBRD1 3.16 0 -2.55 0 MirTarget -0.52 0 NA
105 hsa-miR-20a-5p CYP2U1 3.16 0 -1.21 0 MirTarget -0.24 0 NA
106 hsa-miR-20a-5p DAB2 3.16 0 -0.69 0.03265 MirTarget; miRNATAP -0.31 0 NA
107 hsa-miR-20a-5p DCUN1D3 3.16 0 -1.23 0 MirTarget -0.13 0 NA
108 hsa-miR-20a-5p DENND5B 3.16 0 -1.35 0.0001 MirTarget; miRNATAP -0.22 2.0E-5 NA
109 hsa-miR-20a-5p DIP2C 3.16 0 -1.11 0 miRNATAP -0.16 0 NA
110 hsa-miR-20a-5p DIXDC1 3.16 0 -3.01 0 mirMAP -0.56 0 NA
111 hsa-miR-20a-5p DLC1 3.16 0 -1.8 0 miRNAWalker2 validate; miRNATAP -0.34 0 NA
112 hsa-miR-20a-5p DLG2 3.16 0 -3.8 0 mirMAP -0.62 0 NA
113 hsa-miR-20a-5p DMD 3.16 0 -3.69 0 mirMAP -0.7 0 NA
114 hsa-miR-20a-5p DNAJB9 3.16 0 -0.44 0.00239 miRNATAP -0.15 0 NA
115 hsa-miR-20a-5p DNAJC27 3.16 0 -0.9 0 MirTarget; miRNATAP -0.12 0 NA
116 hsa-miR-20a-5p DPP8 3.16 0 -0.52 0.02104 mirMAP -0.17 0 NA
117 hsa-miR-20a-5p DPYD 3.16 0 -1.71 0.00028 MirTarget -0.44 0 NA
118 hsa-miR-20a-5p DPYSL2 3.16 0 -1.76 0 MirTarget; miRNATAP -0.35 0 NA
119 hsa-miR-20a-5p DRAM1 3.16 0 -0.14 0.60873 mirMAP -0.23 0 NA
120 hsa-miR-20a-5p DST 3.16 0 -1.12 9.0E-5 mirMAP -0.25 0 NA
121 hsa-miR-20a-5p DUSP8 3.16 0 -2.17 0 MirTarget; miRNATAP -0.28 0 NA
122 hsa-miR-20a-5p ECE1 3.16 0 -0.29 0.08009 mirMAP -0.1 2.0E-5 NA
123 hsa-miR-20a-5p EDA2R 3.16 0 -1.5 0.00021 MirTarget -0.34 0 NA
124 hsa-miR-20a-5p EEA1 3.16 0 -0.49 0.00741 MirTarget; miRNATAP -0.19 0 NA
125 hsa-miR-20a-5p EGR2 3.16 0 -2.81 0 MirTarget; miRNATAP -0.52 0 23924943 Involvement of miR 20a in promoting gastric cancer progression by targeting early growth response 2 EGR2; Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression; Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a miR-20a was involved in the carcinogenesis of GC through modulation of the EGR2 signaling pathway
126 hsa-miR-20a-5p EIF5A2 3.16 0 -1.12 0.00497 miRNATAP -0.3 0 NA
127 hsa-miR-20a-5p ELK3 3.16 0 -0.31 0.25641 MirTarget; miRNATAP -0.25 0 NA
128 hsa-miR-20a-5p ENPP1 3.16 0 -2.1 0 mirMAP -0.52 0 NA
129 hsa-miR-20a-5p ENTPD1 3.16 0 -1.12 0 mirMAP -0.3 0 NA
130 hsa-miR-20a-5p EPAS1 3.16 0 -0.53 0.02805 miRNATAP -0.23 0 NA
131 hsa-miR-20a-5p EPHA4 3.16 0 0.35 0.33925 miRNATAP -0.11 0.04745 NA
132 hsa-miR-20a-5p EPHA7 3.16 0 -4.2 0 miRNATAP -0.68 0 NA
133 hsa-miR-20a-5p ESYT2 3.16 0 -0.75 0 mirMAP -0.14 0 NA
134 hsa-miR-20a-5p ETV1 3.16 0 -0.69 0.03823 MirTarget; miRNATAP -0.35 0 NA
135 hsa-miR-20a-5p F3 3.16 0 -1.93 0.00015 MirTarget; miRNATAP -0.26 0.00067 NA
136 hsa-miR-20a-5p FAM102A 3.16 0 -0.85 0 miRNATAP -0.15 0 NA
137 hsa-miR-20a-5p FAM117A 3.16 0 -1.06 0 miRNATAP -0.13 2.0E-5 NA
138 hsa-miR-20a-5p FAM189A1 3.16 0 -1.96 0.00881 MirTarget; miRNATAP -0.28 0.01265 NA
139 hsa-miR-20a-5p FAM46C 3.16 0 -1.66 0 MirTarget; miRNATAP -0.23 0 NA
140 hsa-miR-20a-5p FAT3 3.16 0 -2.79 0 mirMAP -0.53 0 NA
141 hsa-miR-20a-5p FAT4 3.16 0 -2.57 0 MirTarget; miRNATAP -0.63 0 NA
142 hsa-miR-20a-5p FBXL5 3.16 0 -0.66 0 miRNATAP -0.13 0 NA
143 hsa-miR-20a-5p FBXO31 3.16 0 -0.84 0 MirTarget -0.11 0 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples
144 hsa-miR-20a-5p FCHO2 3.16 0 -0.44 0.00271 miRNATAP -0.1 0 NA
145 hsa-miR-20a-5p FEM1C 3.16 0 -0.86 0 MirTarget; miRNATAP -0.1 0 NA
146 hsa-miR-20a-5p FGD5 3.16 0 -1.17 0.00053 MirTarget; miRNATAP -0.32 0 NA
147 hsa-miR-20a-5p FGF7 3.16 0 -3.51 0 miRNAWalker2 validate -0.87 0 NA
148 hsa-miR-20a-5p FGFR1 3.16 0 -2.88 0 mirMAP -0.56 0 NA
149 hsa-miR-20a-5p FGL2 3.16 0 -3.72 0 MirTarget -0.66 0 NA
150 hsa-miR-20a-5p FHL2 3.16 0 -0.45 0.13074 mirMAP -0.16 0.00036 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF GENE EXPRESSION 103 1733 3.958e-16 1.841e-12
2 CELL DEVELOPMENT 87 1426 2.811e-14 6.54e-11
3 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 99 1784 1.283e-13 1.989e-10
4 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 99 1805 2.624e-13 3.052e-10
5 TISSUE DEVELOPMENT 88 1518 3.553e-13 3.306e-10
6 MUSCLE STRUCTURE DEVELOPMENT 41 432 6.189e-13 4.799e-10
7 RESPONSE TO ENDOGENOUS STIMULUS 84 1450 1.404e-12 9.336e-10
8 REGULATION OF CELL DIFFERENTIATION 85 1492 2.464e-12 1.433e-09
9 REGULATION OF PHOSPHORUS METABOLIC PROCESS 89 1618 4.678e-12 2.418e-09
10 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 65 1004 6.23e-12 2.899e-09
11 NEUROGENESIS 80 1402 1.128e-11 4.77e-09
12 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 88 1672 6.506e-11 2.523e-08
13 REGULATION OF CELLULAR COMPONENT MOVEMENT 53 771 7.608e-11 2.723e-08
14 MUSCLE TISSUE DEVELOPMENT 29 275 1.359e-10 4.518e-08
15 CARDIOVASCULAR SYSTEM DEVELOPMENT 53 788 1.685e-10 4.613e-08
16 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 51 740 1.627e-10 4.613e-08
17 CIRCULATORY SYSTEM DEVELOPMENT 53 788 1.685e-10 4.613e-08
18 SKELETAL SYSTEM DEVELOPMENT 38 455 1.973e-10 5.101e-08
19 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 61 1008 4.466e-10 1.094e-07
20 REGULATION OF PROTEIN MODIFICATION PROCESS 87 1710 4.732e-10 1.101e-07
21 INTRACELLULAR SIGNAL TRANSDUCTION 82 1572 5.068e-10 1.123e-07
22 NEURON DIFFERENTIATION 55 874 8.623e-10 1.824e-07
23 NEGATIVE REGULATION OF GENE EXPRESSION 78 1493 1.346e-09 2.476e-07
24 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 61 1036 1.294e-09 2.476e-07
25 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 61 1036 1.294e-09 2.476e-07
26 REGULATION OF CELL DEVELOPMENT 53 836 1.384e-09 2.476e-07
27 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 90 1848 2.026e-09 3.491e-07
28 MUSCLE CELL DIFFERENTIATION 25 237 2.575e-09 4.279e-07
29 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 77 1492 3.012e-09 4.833e-07
30 RESPONSE TO HORMONE 54 893 5.02e-09 7.786e-07
31 EPITHELIUM DEVELOPMENT 56 945 5.231e-09 7.851e-07
32 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 82 1656 5.745e-09 8.101e-07
33 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 38 513 5.698e-09 8.101e-07
34 CENTRAL NERVOUS SYSTEM DEVELOPMENT 53 872 5.923e-09 8.106e-07
35 HEART DEVELOPMENT 35 466 1.637e-08 2.176e-06
36 POSITIVE REGULATION OF CELL DEVELOPMENT 35 472 2.258e-08 2.919e-06
37 REGULATION OF OSSIFICATION 20 178 3.529e-08 4.438e-06
38 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 61 1135 3.856e-08 4.721e-06
39 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 46 750 4.885e-08 5.828e-06
40 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 43 689 8.418e-08 9.707e-06
41 ORGAN MORPHOGENESIS 49 841 8.554e-08 9.707e-06
42 POSITIVE REGULATION OF MOLECULAR FUNCTION 83 1791 8.77e-08 9.716e-06
43 POSITIVE REGULATION OF CELL COMMUNICATION 74 1532 9.792e-08 1.06e-05
44 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 1.027e-07 1.086e-05
45 POSITIVE REGULATION OF NEURON DIFFERENTIATION 26 306 1.086e-07 1.123e-05
46 BONE DEVELOPMENT 18 156 1.135e-07 1.148e-05
47 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 32 437 1.221e-07 1.209e-05
48 REGULATION OF NEURON DIFFERENTIATION 37 554 1.315e-07 1.274e-05
49 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 73 1517 1.404e-07 1.333e-05
50 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 60 1152 1.504e-07 1.372e-05
51 POSITIVE REGULATION OF CELL DEATH 39 605 1.503e-07 1.372e-05
52 POSITIVE REGULATION OF LOCOMOTION 31 420 1.618e-07 1.448e-05
53 NEURON DEVELOPMENT 42 687 2.096e-07 1.84e-05
54 CARTILAGE DEVELOPMENT 17 147 2.468e-07 2.127e-05
55 NEGATIVE REGULATION OF CELL PROLIFERATION 40 643 2.635e-07 2.229e-05
56 CELLULAR COMPONENT MORPHOGENESIS 50 900 2.683e-07 2.229e-05
57 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 49 876 2.91e-07 2.375e-05
58 REGULATION OF KINASE ACTIVITY 45 776 3.385e-07 2.716e-05
59 PROTEIN PHOSPHORYLATION 51 944 4.712e-07 3.716e-05
60 HEAD DEVELOPMENT 42 709 4.857e-07 3.723e-05
61 TELENCEPHALON DEVELOPMENT 21 228 4.881e-07 3.723e-05
62 STRIATED MUSCLE CELL DIFFERENTIATION 18 173 5.417e-07 4.001e-05
63 RESPONSE TO MECHANICAL STIMULUS 20 210 5.363e-07 4.001e-05
64 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 58 1142 5.65e-07 4.107e-05
65 BEHAVIOR 34 516 5.853e-07 4.19e-05
66 FOREBRAIN DEVELOPMENT 27 357 6.386e-07 4.502e-05
67 NEURON PROJECTION MORPHOGENESIS 29 402 6.529e-07 4.534e-05
68 CONNECTIVE TISSUE DEVELOPMENT 19 194 6.717e-07 4.596e-05
69 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 52 983 6.833e-07 4.608e-05
70 REGULATION OF CELL PROLIFERATION 70 1496 7.403e-07 4.921e-05
71 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 45 799 7.571e-07 4.961e-05
72 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 42 724 8.402e-07 5.43e-05
73 MUSCLE ORGAN DEVELOPMENT 23 277 8.811e-07 5.616e-05
74 CELLULAR RESPONSE TO HORMONE STIMULUS 35 552 9.728e-07 6.036e-05
75 TUBE DEVELOPMENT 35 552 9.728e-07 6.036e-05
76 POSITIVE REGULATION OF RESPONSE TO STIMULUS 84 1929 9.97e-07 6.104e-05
77 RESPONSE TO ABIOTIC STIMULUS 53 1024 1.027e-06 6.206e-05
78 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 66 1395 1.092e-06 6.511e-05
79 REGULATION OF SYSTEM PROCESS 33 507 1.127e-06 6.637e-05
80 PHOSPHORYLATION 60 1228 1.268e-06 7.378e-05
81 REGULATION OF MAPK CASCADE 39 660 1.341e-06 7.703e-05
82 RESPONSE TO OXYGEN CONTAINING COMPOUND 65 1381 1.585e-06 8.995e-05
83 VASCULATURE DEVELOPMENT 31 469 1.736e-06 9.732e-05
84 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 44 801 1.953e-06 0.0001082
85 NEURON PROJECTION DEVELOPMENT 34 545 1.997e-06 0.0001093
86 RESPONSE TO STEROID HORMONE 32 497 2.067e-06 0.0001118
87 ACTIN FILAMENT BASED PROCESS 30 450 2.147e-06 0.0001148
88 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 84 1977 2.665e-06 0.0001394
89 DEVELOPMENTAL MATURATION 18 193 2.667e-06 0.0001394
90 CARDIAC MUSCLE TISSUE DEVELOPMENT 15 140 3.299e-06 0.0001706
91 CELL PROJECTION ORGANIZATION 47 902 3.639e-06 0.0001861
92 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 51 1021 4.575e-06 0.0002289
93 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 162 4.557e-06 0.0002289
94 POSITIVE REGULATION OF CATALYTIC ACTIVITY 68 1518 4.886e-06 0.0002393
95 SENSORY ORGAN DEVELOPMENT 31 493 4.838e-06 0.0002393
96 NEGATIVE REGULATION OF PHOSPHORYLATION 28 422 5.131e-06 0.0002487
97 MUSCLE CELL DEVELOPMENT 14 128 5.481e-06 0.0002629
98 REGULATION OF TRANSFERASE ACTIVITY 48 946 5.848e-06 0.0002777
99 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 7.907e-06 0.0003716
100 NEGATIVE REGULATION OF CELL DIFFERENTIATION 35 609 8.643e-06 0.0004021
101 ORGAN GROWTH 10 68 8.795e-06 0.0004052
102 POSITIVE REGULATION OF CELL DIFFERENTIATION 43 823 8.983e-06 0.0004098
103 REGULATION OF MEMBRANE POTENTIAL 24 343 1.007e-05 0.0004548
104 RHYTHMIC PROCESS 22 298 1.02e-05 0.0004561
105 REGULATION OF CELL SUBSTRATE ADHESION 16 173 1.058e-05 0.0004689
106 RESPONSE TO NITROGEN COMPOUND 44 859 1.153e-05 0.000506
107 POSITIVE REGULATION OF MAPK CASCADE 29 470 1.397e-05 0.0005991
108 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 29 470 1.397e-05 0.0005991
109 EPITHELIAL CELL DIFFERENTIATION 30 495 1.404e-05 0.0005991
110 REGULATION OF CATABOLIC PROCESS 39 731 1.484e-05 0.0006268
111 REGULATION OF BINDING 21 283 1.495e-05 0.0006268
112 POSITIVE REGULATION OF CELL PROLIFERATION 42 814 1.544e-05 0.0006413
113 ENDOCHONDRAL BONE MORPHOGENESIS 8 45 1.682e-05 0.0006927
114 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 1.817e-05 0.0007415
115 SKELETAL SYSTEM MORPHOGENESIS 17 201 1.838e-05 0.0007436
116 MESONEPHROS DEVELOPMENT 11 90 1.934e-05 0.0007756
117 KIDNEY EPITHELIUM DEVELOPMENT 13 125 2.04e-05 0.0008114
118 REGULATION OF ACTIN FILAMENT BASED PROCESS 22 312 2.082e-05 0.0008212
119 CHONDROCYTE DIFFERENTIATION 9 60 2.102e-05 0.0008219
120 SINGLE ORGANISM BEHAVIOR 25 384 2.252e-05 0.0008731
121 REGULATION OF CELL DEATH 64 1472 2.417e-05 0.0009293
122 BLOOD VESSEL MORPHOGENESIS 24 364 2.67e-05 0.001018
123 RESPONSE TO EXTERNAL STIMULUS 75 1821 2.893e-05 0.001086
124 OSSIFICATION 19 251 2.877e-05 0.001086
125 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 541 2.993e-05 0.001105
126 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 31 541 2.993e-05 0.001105
127 HOMEOSTATIC PROCESS 59 1337 3.393e-05 0.001214
128 UROGENITAL SYSTEM DEVELOPMENT 21 299 3.386e-05 0.001214
129 BONE MORPHOGENESIS 10 79 3.386e-05 0.001214
130 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 18 232 3.358e-05 0.001214
131 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 46 957 3.556e-05 0.001263
132 NEGATIVE REGULATION OF CELL COMMUNICATION 54 1192 3.726e-05 0.001313
133 REGULATION OF CELL ADHESION 34 629 4.06e-05 0.00142
134 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 21 303 4.111e-05 0.001428
135 PALLIUM DEVELOPMENT 14 153 4.205e-05 0.001449
136 RESPONSE TO GROWTH FACTOR 28 475 4.422e-05 0.001513
137 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 13 135 4.619e-05 0.001569
138 CELLULAR RESPONSE TO NITROGEN COMPOUND 29 505 5.184e-05 0.001748
139 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 5 17 5.267e-05 0.001763
140 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 5.357e-05 0.001778
141 SKELETAL MUSCLE ORGAN DEVELOPMENT 13 137 5.387e-05 0.001778
142 RESPONSE TO LIPID 43 888 5.437e-05 0.001782
143 RESPONSE TO DRUG 26 431 5.636e-05 0.001834
144 POSITIVE REGULATION OF KINASE ACTIVITY 28 482 5.706e-05 0.001844
145 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 8 53 5.778e-05 0.001854
146 NEGATIVE REGULATION OF CELL CYCLE 26 433 6.084e-05 0.001939
147 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 56 1275 6.182e-05 0.001957
148 RESPONSE TO WOUNDING 31 563 6.31e-05 0.001984
149 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 11 103 6.87e-05 0.002145
150 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 9 70 7.367e-05 0.002285
151 PLASMA MEMBRANE ORGANIZATION 16 203 7.531e-05 0.002321
152 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 8 55 7.588e-05 0.002323
153 MULTICELLULAR ORGANISMAL SIGNALING 12 123 7.919e-05 0.002408
154 NEURON PROJECTION GUIDANCE 16 205 8.457e-05 0.002539
155 REGULATION OF BLOOD CIRCULATION 20 295 8.446e-05 0.002539
156 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 15 184 8.585e-05 0.002561
157 LOCOMOTION 50 1114 9.217e-05 0.002732
158 COGNITION 18 251 9.326e-05 0.002746
159 EPITHELIAL CELL DEVELOPMENT 15 186 9.698e-05 0.002838
160 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 58 1360 0.0001014 0.002948
161 REGULATION OF EPITHELIAL CELL MIGRATION 14 166 0.0001022 0.002953
162 CELL PART MORPHOGENESIS 33 633 0.0001049 0.002995
163 REGULATION OF CELL MATRIX ADHESION 10 90 0.0001045 0.002995
164 BIOLOGICAL ADHESION 47 1032 0.0001072 0.003042
165 CARDIAC MUSCLE CELL DIFFERENTIATION 9 74 0.0001144 0.003225
166 REGULATION OF CELL CYCLE 44 949 0.0001201 0.003367
167 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 190 0.0001231 0.003429
168 EMBRYONIC HEMOPOIESIS 5 20 0.0001238 0.003429
169 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 11 111 0.0001356 0.003734
170 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 32 616 0.0001421 0.00389
171 CELLULAR RESPONSE TO LIPID 26 457 0.0001456 0.003963
172 ACTION POTENTIAL 10 94 0.0001508 0.004033
173 RESPONSE TO BMP 10 94 0.0001508 0.004033
174 CELLULAR RESPONSE TO BMP STIMULUS 10 94 0.0001508 0.004033
175 REGULATION OF EPITHELIAL CELL PROLIFERATION 19 285 0.0001569 0.004125
176 MAINTENANCE OF CELL NUMBER 12 132 0.000156 0.004125
177 REGULATION OF ION TRANSPORT 31 592 0.0001564 0.004125
178 REPRODUCTIVE SYSTEM DEVELOPMENT 24 408 0.0001582 0.004135
179 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 5 21 0.0001591 0.004135
180 MEMBRANE DEPOLARIZATION 8 61 0.0001604 0.004146
181 CELLULAR RESPONSE TO ABIOTIC STIMULUS 18 263 0.0001678 0.004313
182 CELL CYCLE ARREST 13 154 0.0001775 0.004538
183 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 0.0001787 0.004545
184 CARDIOCYTE DIFFERENTIATION 10 96 0.0001798 0.004546
185 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 15 197 0.0001835 0.004616
186 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 0.0001846 0.004617
187 REGULATION OF DEVELOPMENTAL GROWTH 19 289 0.0001877 0.004671
188 GLAND MORPHOGENESIS 10 97 0.0001959 0.004848
189 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 31 602 0.00021 0.005169
190 LIPID PHOSPHORYLATION 10 99 0.0002318 0.005678
191 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 27 498 0.0002379 0.005795
192 SYSTEM PROCESS 70 1785 0.0002405 0.005829
193 REGULATION OF JNK CASCADE 13 159 0.0002435 0.005872
194 REGULATION OF CELLULAR RESPONSE TO STRESS 34 691 0.0002456 0.005891
195 POSITIVE REGULATION OF CATABOLIC PROCESS 23 395 0.0002495 0.005953
196 REGULATION OF HOMEOSTATIC PROCESS 25 447 0.0002521 0.005955
197 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 5 23 0.0002521 0.005955
198 REGULATION OF CARDIAC MUSCLE CONTRACTION 8 66 0.0002797 0.006573
199 TISSUE MORPHOGENESIS 28 533 0.0003062 0.00716
200 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 207 0.0003138 0.007265
201 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 31 616 0.0003124 0.007265
202 CHEMICAL HOMEOSTASIS 40 874 0.0003184 0.00731
203 REGULATION OF CIRCADIAN RHYTHM 10 103 0.0003205 0.00731
204 EYE DEVELOPMENT 20 326 0.0003195 0.00731
205 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 18 278 0.0003307 0.007465
206 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 0.0003305 0.007465
207 HEART PROCESS 9 85 0.0003321 0.007465
208 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 23 404 0.0003435 0.007684
209 EXTRACELLULAR STRUCTURE ORGANIZATION 19 304 0.0003555 0.007915
210 MEMBRANE ASSEMBLY 5 25 0.0003816 0.008454
211 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 6 38 0.000384 0.008468
212 MESONEPHRIC TUBULE MORPHOGENESIS 7 53 0.0003938 0.008576
213 REGULATION OF NEURON PROJECTION DEVELOPMENT 23 408 0.0003944 0.008576
214 SKELETAL MUSCLE CELL DIFFERENTIATION 7 53 0.0003938 0.008576
215 RESPONSE TO ORGANIC CYCLIC COMPOUND 41 917 0.0004307 0.009321
216 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 437 0.000433 0.009327
217 TRABECULA MORPHOGENESIS 6 39 0.0004441 0.009522
218 DENTATE GYRUS DEVELOPMENT 4 15 0.0004697 0.009868
219 NEPHRIC DUCT DEVELOPMENT 4 15 0.0004697 0.009868
220 RESPONSE TO OXYGEN LEVELS 19 311 0.0004708 0.009868
221 ENTRAINMENT OF CIRCADIAN CLOCK 5 26 0.0004625 0.009868
222 VENOUS BLOOD VESSEL DEVELOPMENT 4 15 0.0004697 0.009868
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 29 328 8.218e-09 5.003e-06
2 ENZYME BINDING 84 1737 1.077e-08 5.003e-06
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 40 629 1.482e-07 3.443e-05
4 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 62 1199 1.178e-07 3.443e-05
5 KINASE ACTIVITY 48 842 2.228e-07 4.14e-05
6 PROTEIN DOMAIN SPECIFIC BINDING 39 624 3.318e-07 5.138e-05
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 21 226 4.217e-07 5.597e-05
8 REGULATORY REGION NUCLEIC ACID BINDING 46 818 5.916e-07 6.87e-05
9 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 25 315 6.876e-07 7.098e-05
10 PROTEIN HOMODIMERIZATION ACTIVITY 42 722 7.818e-07 7.263e-05
11 KINASE BINDING 37 606 1.171e-06 9.89e-05
12 IDENTICAL PROTEIN BINDING 59 1209 1.63e-06 0.0001262
13 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 51 992 2.021e-06 0.0001444
14 TRANSCRIPTION FACTOR BINDING 33 524 2.31e-06 0.0001533
15 PROTEIN DIMERIZATION ACTIVITY 56 1149 3.187e-06 0.0001974
16 MACROMOLECULAR COMPLEX BINDING 64 1399 4.897e-06 0.0002843
17 RECEPTOR BINDING 66 1476 7.258e-06 0.0003966
18 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 6 20 7.982e-06 0.0004119
19 PROTEIN KINASE ACTIVITY 36 640 1.028e-05 0.0005027
20 SEQUENCE SPECIFIC DNA BINDING 49 1037 3.041e-05 0.001412
21 ACTIN BINDING 25 393 3.305e-05 0.001462
22 CYTOSKELETAL PROTEIN BINDING 41 819 3.891e-05 0.001643
23 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 17 228 9.029e-05 0.003647
24 CORE PROMOTER PROXIMAL REGION DNA BINDING 23 371 9.982e-05 0.003864
25 CYTOKINE BINDING 10 92 0.0001259 0.004678
26 PROTEIN COMPLEX BINDING 43 935 0.0001714 0.006124
27 DOUBLE STRANDED DNA BINDING 37 764 0.0001804 0.006206
28 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 9 81 0.0002303 0.007643
29 GLYCOPROTEIN BINDING 10 101 0.0002732 0.008751
30 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 30 588 0.0003094 0.00958
31 SODIUM CHANNEL ACTIVITY 6 37 0.0003305 0.009903
NumGOOverlapSizeP ValueAdj. P Value
1 ACTIN CYTOSKELETON 29 444 4.729e-06 0.0006905
2 CELL JUNCTION 56 1151 3.358e-06 0.0006905
3 MEMBRANE MICRODOMAIN 23 288 1.723e-06 0.0006905
4 MEMBRANE REGION 55 1134 4.536e-06 0.0006905
5 INTRINSIC COMPONENT OF PLASMA MEMBRANE 71 1649 1.144e-05 0.0009546
6 CONTRACTILE FIBER 18 211 9.322e-06 0.0009546
7 NEURON PROJECTION 47 942 1.136e-05 0.0009546
8 CELL SUBSTRATE JUNCTION 26 398 1.46e-05 0.0009722
9 CELL PROJECTION 75 1786 1.498e-05 0.0009722
10 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 1.817e-05 0.001061
11 CYTOSKELETON 80 1967 2.35e-05 0.001248
12 NEURON PART 57 1265 2.602e-05 0.001266
13 ANCHORING JUNCTION 29 489 2.903e-05 0.001304
14 SODIUM CHANNEL COMPLEX 5 17 5.267e-05 0.002051
15 MICROTUBULE PLUS END 5 17 5.267e-05 0.002051
16 I BAND 12 121 6.749e-05 0.002436
17 PLASMA MEMBRANE RAFT 10 86 7.091e-05 0.002436
18 TRANSCRIPTIONAL REPRESSOR COMPLEX 9 74 0.0001144 0.003515
19 MAIN AXON 8 58 0.0001117 0.003515
20 BASAL PLASMA MEMBRANE 6 33 0.0001717 0.005015
21 MICROTUBULE END 5 22 0.0002015 0.005417
22 A BAND 6 34 0.0002041 0.005417
23 CELL LEADING EDGE 21 350 0.0003079 0.007522
24 BASAL PART OF CELL 7 51 0.0003091 0.007522
25 EXTRACELLULAR MATRIX COMPONENT 11 125 0.0003853 0.008654
26 SARCOLEMMA 11 125 0.0003853 0.008654
27 CELL CELL JUNCTION 22 383 0.0004067 0.008797

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 25 352 5.084e-06 0.0002644
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 6.262e-05 0.001456
3 cGMP_PKG_signaling_pathway_hsa04022 14 163 8.398e-05 0.001456
4 FoxO_signaling_pathway_hsa04068 12 132 0.000156 0.002029
5 Focal_adhesion_hsa04510 15 199 0.000205 0.002132
6 TNF_signaling_pathway_hsa04668 10 108 0.0004694 0.004068
7 MAPK_signaling_pathway_hsa04010 18 295 0.0006673 0.004957
8 p53_signaling_pathway_hsa04115 7 68 0.00178 0.01157
9 Hippo_signaling_pathway_hsa04390 11 154 0.002151 0.01243
10 Jak_STAT_signaling_pathway_hsa04630 11 162 0.003188 0.01623
11 Sphingolipid_signaling_pathway_hsa04071 9 118 0.003433 0.01623
12 AMPK_signaling_pathway_hsa04152 9 121 0.004056 0.01701
13 HIF_1_signaling_pathway_hsa04066 8 100 0.004252 0.01701
14 Autophagy_animal_hsa04140 9 128 0.005853 0.01999
15 TGF_beta_signaling_pathway_hsa04350 7 84 0.005863 0.01999
16 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.006151 0.01999
17 Rap1_signaling_pathway_hsa04015 12 206 0.007201 0.02203
18 Cellular_senescence_hsa04218 10 160 0.008508 0.02458
19 Phospholipase_D_signaling_pathway_hsa04072 9 146 0.01329 0.03637
20 ECM_receptor_interaction_hsa04512 6 82 0.01896 0.04929
21 Apelin_signaling_pathway_hsa04371 8 137 0.02534 0.06109
22 Gap_junction_hsa04540 6 88 0.02584 0.06109
23 Ras_signaling_pathway_hsa04014 11 232 0.03807 0.08607
24 mTOR_signaling_pathway_hsa04150 8 151 0.04153 0.08998
25 Cytokine_cytokine_receptor_interaction_hsa04060 12 270 0.04718 0.09813
26 cAMP_signaling_pathway_hsa04024 9 198 0.07044 0.1409
27 Wnt_signaling_pathway_hsa04310 7 146 0.08307 0.16
28 Regulation_of_actin_cytoskeleton_hsa04810 9 208 0.08918 0.1656
29 Endocytosis_hsa04144 10 244 0.09973 0.1743
30 Oocyte_meiosis_hsa04114 6 124 0.1006 0.1743
31 ABC_transporters_hsa02010 3 45 0.1087 0.1823
32 Adherens_junction_hsa04520 4 72 0.1141 0.1854
33 Cell_adhesion_molecules_.CAMs._hsa04514 6 145 0.1706 0.2679
34 ErbB_signaling_pathway_hsa04012 4 85 0.1752 0.2679
35 Calcium_signaling_pathway_hsa04020 7 182 0.1891 0.2794
36 VEGF_signaling_pathway_hsa04370 3 59 0.1934 0.2794
37 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.2504 0.3519
38 Tight_junction_hsa04530 6 170 0.273 0.3662
39 Ferroptosis_hsa04216 2 40 0.2747 0.3662
40 Apoptosis_hsa04210 5 138 0.2819 0.3665
41 Hedgehog_signaling_pathway_hsa04340 2 47 0.3413 0.4328
42 Notch_signaling_pathway_hsa04330 2 48 0.3507 0.4341
43 Cell_cycle_hsa04110 4 124 0.3952 0.4779
44 Necroptosis_hsa04217 5 164 0.4137 0.489
45 Mitophagy_animal_hsa04137 2 65 0.5006 0.5785
46 Phagosome_hsa04145 4 152 0.5511 0.623
47 Lysosome_hsa04142 3 123 0.6159 0.6672
48 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.8452 0.8969

Quest ID: adf14b356c1e1af7ea7801ebea63161d