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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p ABCA1 -0.14 0.92885 -0.1 0.8422 mirMAP -0.32 0 NA
2 hsa-miR-21-5p ABCA10 -0.14 0.92885 -0.77 0.00842 mirMAP -1.05 0 NA
3 hsa-miR-21-5p ACAT1 -0.14 0.92885 -0.23 0.67804 miRNAWalker2 validate -0.3 0 NA
4 hsa-miR-21-5p ACER3 -0.14 0.92885 0.14 0.71436 mirMAP -0.27 0 NA
5 hsa-miR-21-5p ACVR2A -0.14 0.92885 0.08 0.83057 miRNATAP -0.23 0 NA
6 hsa-miR-21-5p AKAP6 -0.14 0.92885 0.35 0.12787 MirTarget -0.61 0 NA
7 hsa-miR-21-5p AKAP9 -0.14 0.92885 -0.46 0.45533 miRNAWalker2 validate -0.17 0 NA
8 hsa-miR-21-5p AKIRIN1 -0.14 0.92885 0.45 0.4082 miRNATAP -0.11 0 NA
9 hsa-miR-21-5p ANKRD46 -0.14 0.92885 -0.13 0.74865 miRNAWalker2 validate; miRTarBase -0.31 0 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC
10 hsa-miR-21-5p ANKS1B -0.14 0.92885 -1.36 0 MirTarget -0.12 0.01421 NA
11 hsa-miR-21-5p ANO3 -0.14 0.92885 0.12 0.7608 mirMAP -0.87 0 NA
12 hsa-miR-21-5p ANXA1 -0.14 0.92885 1.16 0.09579 MirTarget -0.47 0 NA
13 hsa-miR-21-5p APC -0.14 0.92885 -0.54 0.25302 miRNAWalker2 validate -0.25 0 23773491; 24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry
14 hsa-miR-21-5p APH1B -0.14 0.92885 -1.21 0.00578 MirTarget -0.29 0 NA
15 hsa-miR-21-5p APOLD1 -0.14 0.92885 -0.38 0.4521 miRNAWalker2 validate -0.52 0 NA
16 hsa-miR-21-5p APPL1 -0.14 0.92885 -0.18 0.74888 miRNAWalker2 validate -0.2 0 NA
17 hsa-miR-21-5p ARHGAP21 -0.14 0.92885 0.96 0.09745 miRNAWalker2 validate -0.3 0 NA
18 hsa-miR-21-5p ARHGAP24 -0.14 0.92885 -0.25 0.45194 MirTarget; miRNATAP -0.31 0 NA
19 hsa-miR-21-5p ARHGEF12 -0.14 0.92885 -0.47 0.49356 miRNAWalker2 validate; MirTarget -0.24 0 NA
20 hsa-miR-21-5p ARID4A -0.14 0.92885 -0.43 0.31434 miRNAWalker2 validate -0.3 0 NA
21 hsa-miR-21-5p ARMC8 -0.14 0.92885 0.15 0.75131 miRNATAP -0.11 0 NA
22 hsa-miR-21-5p ARMCX1 -0.14 0.92885 -0.44 0.35381 MirTarget -0.22 0 NA
23 hsa-miR-21-5p ART4 -0.14 0.92885 -0.1 0.80475 mirMAP -0.75 0 NA
24 hsa-miR-21-5p ATF2 -0.14 0.92885 -0.09 0.80911 miRNAWalker2 validate -0.23 0 NA
25 hsa-miR-21-5p ATM -0.14 0.92885 -0.05 0.92324 mirMAP -0.23 0 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy
26 hsa-miR-21-5p ATMIN -0.14 0.92885 0.28 0.62467 miRNAWalker2 validate -0.16 0 NA
27 hsa-miR-21-5p ATP11B -0.14 0.92885 0.92 0.0704 miRNAWalker2 validate -0.19 0 NA
28 hsa-miR-21-5p ATP2B2 -0.14 0.92885 1.34 1.0E-5 mirMAP -0.26 0.00043 NA
29 hsa-miR-21-5p ATP2B4 -0.14 0.92885 0.04 0.94791 miRNAWalker2 validate; MirTarget -0.27 0 NA
30 hsa-miR-21-5p ATRN -0.14 0.92885 -0.2 0.73488 miRNATAP -0.1 0 NA
31 hsa-miR-21-5p ATRX -0.14 0.92885 -0.31 0.60025 miRNAWalker2 validate -0.25 0 NA
32 hsa-miR-21-5p ATXN3 -0.14 0.92885 0.04 0.91739 mirMAP -0.17 0 NA
33 hsa-miR-21-5p AUTS2 -0.14 0.92885 -0.08 0.88789 miRNAWalker2 validate -0.11 0.00084 NA
34 hsa-miR-21-5p B3GNT5 -0.14 0.92885 2.59 0 miRNAWalker2 validate -0.31 0 NA
35 hsa-miR-21-5p BACE1 -0.14 0.92885 0 0.99849 mirMAP -0.19 0 NA
36 hsa-miR-21-5p BBS12 -0.14 0.92885 -0.32 0.20998 MirTarget -0.23 0 NA
37 hsa-miR-21-5p BCL2 -0.14 0.92885 -1.88 0.00098 miRNAWalker2 validate; miRTarBase -0.49 0 26555418; 21468550; 25994220; 25381586; 23359184; 22964582; 21376256 The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
38 hsa-miR-21-5p BCL6 -0.14 0.92885 0.04 0.94311 miRNAWalker2 validate -0.3 0 NA
39 hsa-miR-21-5p BDH2 -0.14 0.92885 0.01 0.98164 miRNAWalker2 validate -0.19 0 NA
40 hsa-miR-21-5p BMP2K -0.14 0.92885 -0.11 0.76209 mirMAP -0.2 0 NA
41 hsa-miR-21-5p BMP3 -0.14 0.92885 0.12 0.7655 MirTarget -1 0 NA
42 hsa-miR-21-5p BMPR2 -0.14 0.92885 -0.23 0.71375 miRNAWalker2 validate; miRTarBase; MirTarget -0.22 0 NA
43 hsa-miR-21-5p BOC -0.14 0.92885 1.09 0.02665 miRNAWalker2 validate -0.37 0 NA
44 hsa-miR-21-5p BTBD3 -0.14 0.92885 0.82 0.093 miRNAWalker2 validate; miRNATAP -0.13 0 NA
45 hsa-miR-21-5p BTBD7 -0.14 0.92885 -0.2 0.68059 miRNAWalker2 validate -0.24 0 NA
46 hsa-miR-21-5p BTG2 -0.14 0.92885 -1.49 0.04452 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2
47 hsa-miR-21-5p C16orf52 -0.14 0.92885 -0.43 0.24716 miRNATAP -0.17 0 NA
48 hsa-miR-21-5p C1orf226 -0.14 0.92885 -0.84 0.08628 mirMAP -0.21 6.0E-5 NA
49 hsa-miR-21-5p CADM2 -0.14 0.92885 -2.36 0 mirMAP; miRNATAP -0.85 0 NA
50 hsa-miR-21-5p CALD1 -0.14 0.92885 0.44 0.55518 miRNAWalker2 validate; MirTarget -0.11 0.00046 NA
51 hsa-miR-21-5p CALN1 -0.14 0.92885 -1.14 0.00178 mirMAP -0.5 0 NA
52 hsa-miR-21-5p CASC4 -0.14 0.92885 -0.61 0.33534 miRNATAP -0.1 1.0E-5 NA
53 hsa-miR-21-5p CASP10 -0.14 0.92885 0.35 0.2959 mirMAP -0.18 0 NA
54 hsa-miR-21-5p CBL -0.14 0.92885 0.4 0.40307 mirMAP -0.22 0 NA
55 hsa-miR-21-5p CCDC121 -0.14 0.92885 -0.15 0.51559 MirTarget -0.27 0 NA
56 hsa-miR-21-5p CCDC152 -0.14 0.92885 -0.86 0.00017 mirMAP -0.36 0 NA
57 hsa-miR-21-5p CCNG1 -0.14 0.92885 -0.41 0.48628 miRNAWalker2 validate -0.35 0 NA
58 hsa-miR-21-5p CCNG2 -0.14 0.92885 -1.09 0.07868 mirMAP -0.1 0.00147 NA
59 hsa-miR-21-5p CDK6 -0.14 0.92885 1.59 0.00053 miRNAWalker2 validate; mirMAP -0.2 3.0E-5 NA
60 hsa-miR-21-5p CEP152 -0.14 0.92885 0.71 0.00105 miRNAWalker2 validate -0.12 3.0E-5 NA
61 hsa-miR-21-5p CEP68 -0.14 0.92885 -0.25 0.61417 miRNATAP -0.39 0 NA
62 hsa-miR-21-5p CEP97 -0.14 0.92885 -0.22 0.39384 miRNAWalker2 validate; MirTarget -0.1 0.00272 NA
63 hsa-miR-21-5p CLDN8 -0.14 0.92885 0.66 0.11205 MirTarget -0.38 9.0E-5 NA
64 hsa-miR-21-5p CLIC2 -0.14 0.92885 0.3 0.41937 MirTarget -0.3 0 NA
65 hsa-miR-21-5p CLIP4 -0.14 0.92885 1.12 0.00734 miRNAWalker2 validate -0.48 0 NA
66 hsa-miR-21-5p CLOCK -0.14 0.92885 -0.11 0.76002 miRNAWalker2 validate -0.24 0 NA
67 hsa-miR-21-5p CNTFR -0.14 0.92885 0.59 0.14799 miRNATAP -1.13 0 NA
68 hsa-miR-21-5p COBLL1 -0.14 0.92885 -0.23 0.62011 miRNAWalker2 validate -0.4 0 NA
69 hsa-miR-21-5p CPEB3 -0.14 0.92885 -0.86 0.00232 miRNAWalker2 validate; MirTarget; miRNATAP -0.34 0 NA
70 hsa-miR-21-5p CREBL2 -0.14 0.92885 -0.55 0.34569 miRNATAP -0.28 0 NA
71 hsa-miR-21-5p CRIM1 -0.14 0.92885 -0.31 0.6343 miRNATAP -0.6 0 NA
72 hsa-miR-21-5p CRTC3 -0.14 0.92885 -0.19 0.72029 mirMAP -0.11 0 NA
73 hsa-miR-21-5p CSRNP3 -0.14 0.92885 -0.3 0.37119 miRNATAP -0.73 0 NA
74 hsa-miR-21-5p CXXC4 -0.14 0.92885 -1.31 0 mirMAP -0.26 3.0E-5 NA
75 hsa-miR-21-5p CYBRD1 -0.14 0.92885 -1.33 0.0758 miRNAWalker2 validate -0.53 0 NA
76 hsa-miR-21-5p CYP4V2 -0.14 0.92885 -0.47 0.30448 miRNAWalker2 validate -0.22 0 NA
77 hsa-miR-21-5p DAAM1 -0.14 0.92885 -0.43 0.32793 miRNAWalker2 validate -0.28 0 NA
78 hsa-miR-21-5p DCP1A -0.14 0.92885 -0.13 0.77497 miRNAWalker2 validate -0.27 0 NA
79 hsa-miR-21-5p DDHD2 -0.14 0.92885 -0 0.9934 miRNAWalker2 validate -0.27 0 NA
80 hsa-miR-21-5p DDR2 -0.14 0.92885 0.43 0.24643 miRNAWalker2 validate -0.62 0 NA
81 hsa-miR-21-5p DDX3X -0.14 0.92885 0 0.99521 miRNAWalker2 validate -0.2 0 NA
82 hsa-miR-21-5p DLG1 -0.14 0.92885 0.14 0.79636 miRNAWalker2 validate -0.15 0 NA
83 hsa-miR-21-5p DLGAP1 -0.14 0.92885 0.53 0.1247 miRNATAP -0.28 0.00212 NA
84 hsa-miR-21-5p DMD -0.14 0.92885 1.62 0.00016 miRNAWalker2 validate -0.92 0 NA
85 hsa-miR-21-5p DMTF1 -0.14 0.92885 0.08 0.86606 miRNAWalker2 validate -0.12 0 NA
86 hsa-miR-21-5p DOCK4 -0.14 0.92885 0.07 0.86467 miRNAWalker2 validate; miRTarBase -0.22 0 NA
87 hsa-miR-21-5p DOCK7 -0.14 0.92885 0.71 0.15566 miRNAWalker2 validate; miRTarBase -0.22 0 NA
88 hsa-miR-21-5p DSE -0.14 0.92885 0.16 0.74414 miRNAWalker2 validate -0.11 6.0E-5 NA
89 hsa-miR-21-5p DST -0.14 0.92885 0.02 0.98236 mirMAP -0.66 0 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen
90 hsa-miR-21-5p DYNC1LI2 -0.14 0.92885 0.17 0.78813 miRNAWalker2 validate -0.19 0 NA
91 hsa-miR-21-5p EGFR -0.14 0.92885 2.45 0 miRNAWalker2 validate; miRTarBase -0.67 0 24198203; 20113523; 24012640; 24331411; 26563758; 19597153; 26026961; 20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status
92 hsa-miR-21-5p EIF1AX -0.14 0.92885 -0.01 0.9895 miRNATAP -0.17 0 NA
93 hsa-miR-21-5p EIF4A2 -0.14 0.92885 -0.08 0.91716 miRNAWalker2 validate; miRTarBase -0.22 0 NA
94 hsa-miR-21-5p EIF4EBP2 -0.14 0.92885 0.1 0.88305 miRNAWalker2 validate -0.35 0 NA
95 hsa-miR-21-5p EIF5 -0.14 0.92885 -0.15 0.82782 miRNAWalker2 validate -0.14 0 NA
96 hsa-miR-21-5p ELF2 -0.14 0.92885 -0.15 0.74935 MirTarget; miRNATAP -0.17 0 NA
97 hsa-miR-21-5p ELOVL7 -0.14 0.92885 1 0.00242 miRNAWalker2 validate -0.24 0 NA
98 hsa-miR-21-5p EPHA4 -0.14 0.92885 0.31 0.35598 miRNAWalker2 validate; miRNATAP -0.4 0 NA
99 hsa-miR-21-5p EPM2A -0.14 0.92885 0.17 0.54145 miRNAWalker2 validate -0.37 0 NA
100 hsa-miR-21-5p EPM2AIP1 -0.14 0.92885 -0.56 0.27055 mirMAP -0.2 0 NA
101 hsa-miR-21-5p ESYT2 -0.14 0.92885 0.43 0.52514 miRNAWalker2 validate; MirTarget -0.17 0 NA
102 hsa-miR-21-5p EXOC5 -0.14 0.92885 0.03 0.9537 miRNAWalker2 validate -0.14 0 NA
103 hsa-miR-21-5p FAM107B -0.14 0.92885 -0.16 0.79198 miRNATAP -0.11 0.00019 NA
104 hsa-miR-21-5p FAM126B -0.14 0.92885 0.11 0.78029 miRNAWalker2 validate -0.22 0 NA
105 hsa-miR-21-5p FAM20B -0.14 0.92885 -0 0.9953 miRNAWalker2 validate -0.1 0 NA
106 hsa-miR-21-5p FAM46A -0.14 0.92885 0.38 0.41443 miRNAWalker2 validate; miRNATAP -0.21 0 NA
107 hsa-miR-21-5p FAM63B -0.14 0.92885 -0.74 0.01954 miRNATAP -0.35 0 NA
108 hsa-miR-21-5p FBXL17 -0.14 0.92885 -0.92 0.04247 miRNAWalker2 validate; miRNATAP -0.29 0 NA
109 hsa-miR-21-5p FBXO11 -0.14 0.92885 0.22 0.69545 miRNAWalker2 validate; miRNATAP -0.15 0 NA
110 hsa-miR-21-5p FBXO3 -0.14 0.92885 -0.38 0.42437 miRNAWalker2 validate -0.16 0 NA
111 hsa-miR-21-5p FCHO2 -0.14 0.92885 -0.61 0.19755 miRNATAP -0.21 0 NA
112 hsa-miR-21-5p FERMT2 -0.14 0.92885 0.06 0.91492 miRNAWalker2 validate -0.4 0 NA
113 hsa-miR-21-5p FGD4 -0.14 0.92885 0.32 0.39156 MirTarget -0.46 0 NA
114 hsa-miR-21-5p FGF1 -0.14 0.92885 -0.65 0.10119 MirTarget -0.37 0 NA
115 hsa-miR-21-5p FGF2 -0.14 0.92885 0.64 0.10706 mirMAP -1 0 NA
116 hsa-miR-21-5p FIGN -0.14 0.92885 1.66 0 miRNAWalker2 validate -0.63 0 NA
117 hsa-miR-21-5p FILIP1L -0.14 0.92885 -0.43 0.38861 miRNAWalker2 validate -0.24 0 NA
118 hsa-miR-21-5p FKBP5 -0.14 0.92885 0.48 0.42817 miRNAWalker2 validate -0.19 0.00017 NA
119 hsa-miR-21-5p FMN1 -0.14 0.92885 -1.29 0 miRNATAP -0.16 0.01106 NA
120 hsa-miR-21-5p FMOD -0.14 0.92885 -1.02 0.12251 miRNAWalker2 validate; miRTarBase -0.39 0 23445447; 19906824 Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members;Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells
121 hsa-miR-21-5p FOXN3 -0.14 0.92885 0.22 0.69194 miRNAWalker2 validate; mirMAP -0.37 0 NA
122 hsa-miR-21-5p FOXP2 -0.14 0.92885 -0.31 0.28517 mirMAP -0.7 0 NA
123 hsa-miR-21-5p FREM2 -0.14 0.92885 1.55 8.0E-5 mirMAP -0.3 0.00441 NA
124 hsa-miR-21-5p FRMD3 -0.14 0.92885 1.47 0 MirTarget -0.85 0 NA
125 hsa-miR-21-5p FZD4 -0.14 0.92885 -0.76 0.18617 mirMAP -0.62 0 NA
126 hsa-miR-21-5p GALNT12 -0.14 0.92885 0.97 7.0E-5 MirTarget -0.16 0.00161 NA
127 hsa-miR-21-5p GFOD1 -0.14 0.92885 0.83 2.0E-5 mirMAP -0.24 0 NA
128 hsa-miR-21-5p GFPT1 -0.14 0.92885 0.17 0.79739 mirMAP -0.14 0 NA
129 hsa-miR-21-5p GLCCI1 -0.14 0.92885 -1.02 0.01247 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 2.0E-5 NA
130 hsa-miR-21-5p GLG1 -0.14 0.92885 0.46 0.51464 miRNAWalker2 validate -0.1 0 NA
131 hsa-miR-21-5p GNAQ -0.14 0.92885 -0.39 0.50275 miRNAWalker2 validate -0.25 0 NA
132 hsa-miR-21-5p GNE -0.14 0.92885 0.33 0.47681 miRNAWalker2 validate -0.36 0 NA
133 hsa-miR-21-5p GNG2 -0.14 0.92885 0 0.99098 miRNATAP -0.41 0 NA
134 hsa-miR-21-5p GOLGA4 -0.14 0.92885 -0.11 0.86419 miRNAWalker2 validate -0.22 0 NA
135 hsa-miR-21-5p GPAM -0.14 0.92885 -0.43 0.40771 miRNAWalker2 validate; mirMAP -1 0 NA
136 hsa-miR-21-5p GPD1L -0.14 0.92885 -1.55 0.00697 miRNAWalker2 validate -0.34 0 NA
137 hsa-miR-21-5p GRAMD3 -0.14 0.92885 0.58 0.20354 MirTarget -0.19 0 NA
138 hsa-miR-21-5p GRIK3 -0.14 0.92885 -3.91 0 mirMAP -0.3 0.00129 NA
139 hsa-miR-21-5p GTF2A1 -0.14 0.92885 -0.31 0.27739 miRNAWalker2 validate -0.28 0 NA
140 hsa-miR-21-5p GTF2I -0.14 0.92885 0.09 0.89098 miRNAWalker2 validate -0.22 0 NA
141 hsa-miR-21-5p GXYLT1 -0.14 0.92885 -0.17 0.68744 mirMAP -0.12 0 NA
142 hsa-miR-21-5p HBP1 -0.14 0.92885 -0.3 0.63076 miRNATAP -0.26 0 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53
143 hsa-miR-21-5p HECTD1 -0.14 0.92885 -0.24 0.71629 miRNAWalker2 validate -0.22 0 NA
144 hsa-miR-21-5p HERPUD2 -0.14 0.92885 -0.03 0.94786 miRNAWalker2 validate -0.11 0 NA
145 hsa-miR-21-5p HIPK1 -0.14 0.92885 -0.24 0.68365 mirMAP -0.2 0 NA
146 hsa-miR-21-5p HIPK3 -0.14 0.92885 -0.2 0.68645 MirTarget -0.52 0 NA
147 hsa-miR-21-5p HIVEP3 -0.14 0.92885 -0.17 0.66422 mirMAP -0.13 0 NA
148 hsa-miR-21-5p HOXA9 -0.14 0.92885 0.3 0.24005 miRNAWalker2 validate -0.5 0 NA
149 hsa-miR-21-5p HPS5 -0.14 0.92885 0.26 0.56019 miRNAWalker2 validate -0.23 0 NA
150 hsa-miR-21-5p HSD17B4 -0.14 0.92885 -1.11 0.07508 MirTarget -0.16 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 91 1784 1.529e-13 7.115e-10
2 POSITIVE REGULATION OF GENE EXPRESSION 84 1733 2.346e-11 5.457e-08
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 81 1672 5.922e-11 9.184e-08
4 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 84 1805 1.821e-10 2.119e-07
5 REGULATION OF CELL DIFFERENTIATION 73 1492 4.048e-10 3.767e-07
6 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 1004 5.699e-10 4.42e-07
7 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 44 689 8.05e-10 5.351e-07
8 REGULATION OF CELL PROLIFERATION 72 1496 1.115e-09 6.487e-07
9 PROTEIN PHOSPHORYLATION 53 944 1.375e-09 7.109e-07
10 CELL DEVELOPMENT 68 1426 5.076e-09 2.147e-06
11 TISSUE DEVELOPMENT 71 1518 4.94e-09 2.147e-06
12 RESPONSE TO ENDOGENOUS STIMULUS 68 1450 9.905e-09 3.841e-06
13 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 74 1656 1.536e-08 5.106e-06
14 NEUROGENESIS 66 1402 1.458e-08 5.106e-06
15 INTRACELLULAR SIGNAL TRANSDUCTION 70 1572 4.626e-08 1.266e-05
16 CARDIOVASCULAR SYSTEM DEVELOPMENT 44 788 4.48e-08 1.266e-05
17 CIRCULATORY SYSTEM DEVELOPMENT 44 788 4.48e-08 1.266e-05
18 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 21 229 7.227e-08 1.868e-05
19 ORGAN MORPHOGENESIS 45 841 1.074e-07 2.547e-05
20 PHOSPHORYLATION 58 1228 1.095e-07 2.547e-05
21 POSITIVE REGULATION OF GROWTH 21 238 1.395e-07 3.091e-05
22 EPITHELIUM DEVELOPMENT 48 945 1.871e-07 3.537e-05
23 KIDNEY EPITHELIUM DEVELOPMENT 15 125 1.703e-07 3.537e-05
24 REGULATION OF EPITHELIAL CELL PROLIFERATION 23 285 1.803e-07 3.537e-05
25 RENAL TUBULE DEVELOPMENT 12 78 1.901e-07 3.537e-05
26 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 50 1008 2.097e-07 3.753e-05
27 REGULATION OF DEVELOPMENTAL GROWTH 23 289 2.314e-07 3.987e-05
28 REGULATION OF PROTEIN MODIFICATION PROCESS 72 1710 2.596e-07 4.314e-05
29 POSITIVE REGULATION OF CELL PROLIFERATION 43 814 2.973e-07 4.627e-05
30 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 50 1021 3.082e-07 4.627e-05
31 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 54 1142 3.035e-07 4.627e-05
32 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 42 799 4.688e-07 6.817e-05
33 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 31 498 4.899e-07 6.908e-05
34 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 79 1977 5.176e-07 7.083e-05
35 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 16 156 5.855e-07 7.583e-05
36 NEGATIVE REGULATION OF CELL DIFFERENTIATION 35 609 5.867e-07 7.583e-05
37 NEGATIVE REGULATION OF CELL PROLIFERATION 36 643 7.485e-07 9.413e-05
38 GROWTH 27 410 9.283e-07 0.0001123
39 REGULATION OF CELL DEATH 63 1472 9.413e-07 0.0001123
40 RESPONSE TO OXYGEN CONTAINING COMPOUND 60 1381 1.087e-06 0.0001264
41 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 39 740 1.152e-06 0.0001308
42 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 64 1517 1.244e-06 0.0001378
43 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 41 801 1.274e-06 0.0001378
44 NEPHRON EPITHELIUM DEVELOPMENT 12 93 1.339e-06 0.0001416
45 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 29 470 1.376e-06 0.0001423
46 TUBE DEVELOPMENT 32 552 1.504e-06 0.0001521
47 UROGENITAL SYSTEM DEVELOPMENT 22 299 1.585e-06 0.000157
48 CELLULAR COMPONENT MORPHOGENESIS 44 900 1.735e-06 0.0001682
49 CENTRAL NERVOUS SYSTEM DEVELOPMENT 43 872 1.835e-06 0.0001742
50 PROTEIN LOCALIZATION 72 1805 1.938e-06 0.0001803
51 SMOOTH MUSCLE TISSUE DEVELOPMENT 6 18 2e-06 0.0001824
52 MESONEPHRIC TUBULE MORPHOGENESIS 9 53 2.8e-06 0.0002459
53 HEAD DEVELOPMENT 37 709 2.751e-06 0.0002459
54 REGULATION OF OSSIFICATION 16 178 3.385e-06 0.0002916
55 REGULATION OF GROWTH 34 633 3.805e-06 0.0003219
56 VASCULATURE DEVELOPMENT 28 469 3.941e-06 0.0003274
57 CELL PROJECTION ORGANIZATION 43 902 4.338e-06 0.000348
58 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 49 1087 4.273e-06 0.000348
59 MUSCLE TISSUE DEVELOPMENT 20 275 5.617e-06 0.0004356
60 TUBE MORPHOGENESIS 22 323 5.565e-06 0.0004356
61 TISSUE MORPHOGENESIS 30 533 5.767e-06 0.0004399
62 REGULATION OF ORGAN GROWTH 10 73 5.919e-06 0.0004442
63 NEGATIVE REGULATION OF GENE EXPRESSION 61 1493 6.298e-06 0.0004454
64 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 61 1492 6.168e-06 0.0004454
65 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 57 1360 6.198e-06 0.0004454
66 MESONEPHROS DEVELOPMENT 11 90 6.317e-06 0.0004454
67 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 45 983 7.315e-06 0.000508
68 NEURON DEVELOPMENT 35 687 8.672e-06 0.000583
69 REGULATION OF KINASE ACTIVITY 38 776 8.771e-06 0.000583
70 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 71 1848 8.526e-06 0.000583
71 PROTEIN AUTOPHOSPHORYLATION 16 192 8.95e-06 0.0005834
72 DEVELOPMENTAL GROWTH 22 333 9.027e-06 0.0005834
73 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 26 437 9.276e-06 0.0005913
74 HEART DEVELOPMENT 27 466 1.01e-05 0.0006353
75 REGULATION OF PHOSPHORUS METABOLIC PROCESS 64 1618 1.024e-05 0.0006356
76 NEURON DIFFERENTIATION 41 874 1.073e-05 0.0006571
77 NEGATIVE REGULATION OF CELL COMMUNICATION 51 1192 1.145e-05 0.0006919
78 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 12 115 1.262e-05 0.000743
79 NEPHRON DEVELOPMENT 12 115 1.262e-05 0.000743
80 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 57 1395 1.308e-05 0.0007608
81 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 49 1135 1.361e-05 0.0007816
82 REGULATION OF TRANSFERASE ACTIVITY 43 946 1.401e-05 0.0007919
83 POSITIVE REGULATION OF CELL DIFFERENTIATION 39 823 1.413e-05 0.0007919
84 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 12 118 1.641e-05 0.0009091
85 MORPHOGENESIS OF AN EPITHELIUM 24 400 1.781e-05 0.0009752
86 POSITIVE REGULATION OF OSSIFICATION 10 84 2.104e-05 0.001139
87 NEGATIVE REGULATION OF CELL CYCLE 25 433 2.279e-05 0.001214
88 BEHAVIOR 28 516 2.296e-05 0.001214
89 NEURON PROJECTION DEVELOPMENT 29 545 2.356e-05 0.001232
90 FORELIMB MORPHOGENESIS 7 40 2.974e-05 0.001521
91 DEFINITIVE HEMOPOIESIS 5 17 2.974e-05 0.001521
92 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 10 88 3.172e-05 0.001604
93 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 31 616 3.599e-05 0.001801
94 RESPONSE TO NITROGEN COMPOUND 39 859 3.658e-05 0.001811
95 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 42 957 3.993e-05 0.001956
96 REGULATION OF CELLULAR COMPONENT MOVEMENT 36 771 4.139e-05 0.002006
97 NEGATIVE REGULATION OF PHOSPHORYLATION 24 422 4.214e-05 0.002022
98 RESPONSE TO ABIOTIC STIMULUS 44 1024 4.286e-05 0.002035
99 RESPONSE TO ACID CHEMICAL 20 319 4.815e-05 0.00224
100 REGULATION OF MAP KINASE ACTIVITY 20 319 4.815e-05 0.00224
101 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 5.066e-05 0.002298
102 NEGATIVE REGULATION OF CELL DEATH 39 872 5.066e-05 0.002298
103 REGULATION OF OSTEOBLAST DIFFERENTIATION 11 112 5.088e-05 0.002298
104 REGULATION OF TRANSPORTER ACTIVITY 15 198 5.173e-05 0.002315
105 CELL CYCLE ARREST 13 154 5.378e-05 0.002377
106 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 27 513 5.415e-05 0.002377
107 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 44 1036 5.622e-05 0.002412
108 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 44 1036 5.622e-05 0.002412
109 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 7 44 5.651e-05 0.002412
110 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 6.216e-05 0.002629
111 POSITIVE REGULATION OF MOLECULAR FUNCTION 66 1791 6.66e-05 0.002792
112 MUSCLE ORGAN DEVELOPMENT 18 277 7.224e-05 0.002975
113 SENSORY ORGAN DEVELOPMENT 26 493 7.184e-05 0.002975
114 DENDRITE DEVELOPMENT 9 79 7.709e-05 0.003146
115 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 47 1152 8.225e-05 0.003328
116 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 207 8.571e-05 0.003438
117 METANEPHROS DEVELOPMENT 9 81 9.387e-05 0.003733
118 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 7 48 0.0001004 0.003958
119 RESPONSE TO GROWTH FACTOR 25 475 0.0001018 0.003982
120 KIDNEY MORPHOGENESIS 9 82 0.0001034 0.004008
121 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 34 0.0001063 0.004055
122 CELLULAR RESPONSE TO NITROGEN COMPOUND 26 505 0.0001061 0.004055
123 CELLULAR MACROMOLECULE LOCALIZATION 49 1234 0.0001116 0.004223
124 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 289 0.0001237 0.004567
125 EMBRYONIC MORPHOGENESIS 27 539 0.0001233 0.004567
126 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 190 0.0001228 0.004567
127 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 541 0.000131 0.004763
128 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 541 0.000131 0.004763
129 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 10 104 0.0001327 0.004788
130 SKELETAL SYSTEM DEVELOPMENT 24 455 0.0001351 0.004834
131 PALATE DEVELOPMENT 9 85 0.0001367 0.004854
132 APPENDAGE DEVELOPMENT 13 169 0.0001387 0.004854
133 LIMB DEVELOPMENT 13 169 0.0001387 0.004854
134 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 7 52 0.0001686 0.005856
135 MYOBLAST DIFFERENTIATION 6 37 0.0001735 0.005979
136 RESPONSE TO HORMONE 38 893 0.0001758 0.006014
137 IMMUNE SYSTEM DEVELOPMENT 28 582 0.000182 0.00618
138 POSITIVE REGULATION OF RESPONSE TO STIMULUS 68 1929 0.0001909 0.006438
139 POST EMBRYONIC DEVELOPMENT 9 89 0.0001948 0.006522
140 POSITIVE REGULATION OF ORGAN GROWTH 6 38 0.0002021 0.006716
141 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 0.000209 0.006898
142 REGULATION OF CELL MATRIX ADHESION 9 90 0.0002122 0.006953
143 FOREBRAIN DEVELOPMENT 20 357 0.000221 0.007192
144 ENERGY RESERVE METABOLIC PROCESS 8 72 0.0002292 0.007405
145 PROTEIN LOCALIZATION TO NUCLEUS 12 156 0.0002485 0.007976
146 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 33 750 0.0002592 0.008261
147 REGULATION OF MAPK CASCADE 30 660 0.0002862 0.00906
148 RESPONSE TO INORGANIC SUBSTANCE 24 479 0.0002896 0.009103
149 POSITIVE REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 4 15 0.0002981 0.009166
150 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 724 0.0002964 0.009166
151 POSITIVE REGULATION OF MAP KINASE ACTIVITY 14 207 0.0002994 0.009166
152 REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 4 15 0.0002981 0.009166
153 SKELETAL MUSCLE ORGAN DEVELOPMENT 11 137 0.0003088 0.009392
154 POSITIVE REGULATION OF HEART GROWTH 5 27 0.0003214 0.009711
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 41 640 2.872e-09 9.91e-07
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 61 1199 3.2e-09 9.91e-07
3 ENZYME BINDING 79 1737 2.047e-09 9.91e-07
4 KINASE ACTIVITY 47 842 1.52e-08 3.53e-06
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 51 992 5.124e-08 9.519e-06
6 PROTEIN SERINE THREONINE KINASE ACTIVITY 30 445 1.382e-07 2.139e-05
7 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 12 81 2.91e-07 3.861e-05
8 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 36 629 4.445e-07 5.162e-05
9 PROTEIN DOMAIN SPECIFIC BINDING 35 624 1.028e-06 0.0001061
10 KINASE BINDING 33 606 3.966e-06 0.0003685
11 GROWTH FACTOR BINDING 13 123 4.782e-06 0.0004039
12 PDZ DOMAIN BINDING 11 90 6.317e-06 0.0004891
13 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 7.107e-06 0.0005079
14 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 24 420 3.908e-05 0.002594
15 SEQUENCE SPECIFIC DNA BINDING 44 1037 5.749e-05 0.00356
16 TRANSLATION REPRESSOR ACTIVITY 5 20 7.041e-05 0.004088
17 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 8 64 9.932e-05 0.005428
18 ADENYL NUCLEOTIDE BINDING 57 1514 0.0001261 0.006506
19 REGULATORY REGION NUCLEIC ACID BINDING 36 818 0.000136 0.006652
NumGOOverlapSizeP ValueAdj. P Value
1 PML BODY 12 97 2.11e-06 0.001232
2 SYNAPSE 35 754 5.959e-05 0.009911
3 RECEPTOR COMPLEX 20 327 6.788e-05 0.009911
4 PLASMA MEMBRANE REGION 41 929 4.366e-05 0.009911

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 1.823e-05 0.000948
2 FoxO_signaling_pathway_hsa04068 12 132 5.04e-05 0.001036
3 PI3K_Akt_signaling_pathway_hsa04151 21 352 6.42e-05 0.001036
4 Cellular_senescence_hsa04218 13 160 7.972e-05 0.001036
5 MAPK_signaling_pathway_hsa04010 18 295 0.0001598 0.001662
6 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.00132 0.01144
7 Ras_signaling_pathway_hsa04014 13 232 0.002686 0.01651
8 Rap1_signaling_pathway_hsa04015 12 206 0.002817 0.01651
9 Hippo_signaling_pathway_hsa04390 10 154 0.002857 0.01651
10 Jak_STAT_signaling_pathway_hsa04630 10 162 0.004102 0.02133
11 p53_signaling_pathway_hsa04115 6 68 0.004516 0.02135
12 Sphingolipid_signaling_pathway_hsa04071 8 118 0.005665 0.02455
13 HIF_1_signaling_pathway_hsa04066 7 100 0.007948 0.03129
14 Regulation_of_actin_cytoskeleton_hsa04810 11 208 0.008425 0.03129
15 Apelin_signaling_pathway_hsa04371 8 137 0.01337 0.04635
16 Gap_junction_hsa04540 6 88 0.01533 0.04969
17 Focal_adhesion_hsa04510 10 199 0.01625 0.04969
18 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.02579 0.07451
19 TGF_beta_signaling_pathway_hsa04350 5 84 0.04299 0.1166
20 ErbB_signaling_pathway_hsa04012 5 85 0.04486 0.1166
21 Phospholipase_D_signaling_pathway_hsa04072 7 146 0.05016 0.1186
22 Wnt_signaling_pathway_hsa04310 7 146 0.05016 0.1186
23 mTOR_signaling_pathway_hsa04150 7 151 0.05808 0.1313
24 Adherens_junction_hsa04520 4 72 0.08205 0.1778
25 Hedgehog_signaling_pathway_hsa04340 3 47 0.09159 0.1905
26 Notch_signaling_pathway_hsa04330 3 48 0.09612 0.1922
27 TNF_signaling_pathway_hsa04668 5 108 0.101 0.1945
28 ECM_receptor_interaction_hsa04512 4 82 0.1175 0.2183
29 Calcium_signaling_pathway_hsa04020 7 182 0.1235 0.2214
30 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.141 0.2444
31 VEGF_signaling_pathway_hsa04370 3 59 0.1514 0.25
32 Cell_cycle_hsa04110 5 124 0.1538 0.25
33 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.1656 0.2551
34 Autophagy_animal_hsa04140 5 128 0.1686 0.2551
35 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.1717 0.2551
36 Tight_junction_hsa04530 6 170 0.1931 0.2743
37 Endocytosis_hsa04144 8 244 0.1952 0.2743
38 ABC_transporters_hsa02010 2 45 0.2739 0.3748
39 cAMP_signaling_pathway_hsa04024 6 198 0.2981 0.3975
40 Oocyte_meiosis_hsa04114 4 124 0.3135 0.4076
41 Apoptosis_hsa04210 4 138 0.386 0.4896
42 AMPK_signaling_pathway_hsa04152 3 121 0.5233 0.6447
43 Peroxisome_hsa04146 2 83 0.5675 0.6707
44 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.6457 0.7462
45 Phagosome_hsa04145 3 152 0.677 0.7653
46 Necroptosis_hsa04217 3 164 0.7257 0.8029
47 Lysosome_hsa04142 2 123 0.7741 0.8248
48 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.9543 0.9925

Quest ID: ae0183ad4de970752942cd111aa92708