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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p AKT3 -0.2 0.80221 0.46 0.53933 miRNATAP -0.55 0 NA
2 hsa-miR-106b-5p AKT3 -0.3 0.86929 0.46 0.53933 miRNATAP -0.91 0 NA
3 hsa-miR-107 AKT3 -0.04 0.98836 0.46 0.53933 PITA; miRanda -0.55 0.00017 NA
4 hsa-miR-1275 AKT3 -0.83 0.08038 0.46 0.53933 PITA -0.27 0 NA
5 hsa-miR-142-3p AKT3 -0.15 0.9461 0.46 0.53933 miRanda -0.2 0.00627 NA
6 hsa-miR-15a-5p AKT3 -0.07 0.96484 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0 NA
7 hsa-miR-15b-5p AKT3 -0.27 0.87097 0.46 0.53933 miRNATAP -0.67 0 NA
8 hsa-miR-16-5p AKT3 0.01 0.99448 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.75 0 NA
9 hsa-miR-17-3p AKT3 0.1 0.96011 0.46 0.53933 miRNATAP -0.52 0 NA
10 hsa-miR-17-5p AKT3 -0.18 0.93454 0.46 0.53933 TargetScan; miRNATAP -0.63 0 NA
11 hsa-miR-181b-5p AKT3 0.16 0.93018 0.46 0.53933 miRNATAP -0.27 0.00963 NA
12 hsa-miR-20a-5p AKT3 -0.18 0.92812 0.46 0.53933 miRNATAP -0.53 0 NA
13 hsa-miR-28-3p AKT3 -0.23 0.93535 0.46 0.53933 miRNATAP -0.52 0.00719 NA
14 hsa-miR-29a-3p AKT3 0.01 0.99698 0.46 0.53933 miRNATAP -0.81 0 NA
15 hsa-miR-29b-3p AKT3 -0.1 0.95899 0.46 0.53933 miRNATAP -0.68 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
16 hsa-miR-32-3p AKT3 -0.57 0.13133 0.46 0.53933 mirMAP -0.56 0 NA
17 hsa-miR-320a AKT3 -0.42 0.8402 0.46 0.53933 PITA; miRanda; miRNATAP -0.33 0.00138 NA
18 hsa-miR-320b AKT3 -0.24 0.85922 0.46 0.53933 PITA; miRanda; miRNATAP -0.25 0.00855 NA
19 hsa-miR-335-3p AKT3 -0.24 0.8845 0.46 0.53933 mirMAP -0.58 0 NA
20 hsa-miR-33a-3p AKT3 -0.79 0.01052 0.46 0.53933 mirMAP -0.49 0 NA
21 hsa-miR-340-5p AKT3 -0 0.99757 0.46 0.53933 mirMAP -0.28 0.006 NA
22 hsa-miR-362-3p AKT3 -0.72 0.03459 0.46 0.53933 miRanda -0.42 0 NA
23 hsa-miR-362-5p AKT3 -0.27 0.75202 0.46 0.53933 PITA; TargetScan; miRNATAP -0.52 0 NA
24 hsa-miR-369-3p AKT3 0.12 0.8323 0.46 0.53933 mirMAP -0.23 0.00901 NA
25 hsa-miR-374a-5p AKT3 -0.34 0.76692 0.46 0.53933 mirMAP -0.58 0 NA
26 hsa-miR-374b-5p AKT3 -0.29 0.8357 0.46 0.53933 mirMAP -0.68 0 NA
27 hsa-miR-421 AKT3 -0.18 0.7347 0.46 0.53933 miRanda; mirMAP -0.46 0 NA
28 hsa-miR-424-5p AKT3 0.25 0.87015 0.46 0.53933 miRNATAP -0.24 0.00104 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth
29 hsa-miR-501-3p AKT3 -0.75 0.55276 0.46 0.53933 miRNATAP -0.5 0 NA
30 hsa-miR-502-3p AKT3 -0.48 0.5143 0.46 0.53933 miRNATAP -0.64 0 NA
31 hsa-miR-502-5p AKT3 -0.71 0.02613 0.46 0.53933 PITA; miRNATAP -0.41 0 NA
32 hsa-miR-505-3p AKT3 -0.47 0.69038 0.46 0.53933 mirMAP -0.77 0 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
33 hsa-miR-548o-3p AKT3 -0.19 0.51773 0.46 0.53933 mirMAP -0.31 8.0E-5 NA
34 hsa-miR-577 AKT3 -1.06 0.32606 0.46 0.53933 mirMAP -0.38 0 NA
35 hsa-miR-663b AKT3 0.1 0.81499 0.46 0.53933 PITA -0.25 1.0E-5 NA
36 hsa-miR-769-5p AKT3 -0.31 0.7357 0.46 0.53933 PITA; miRNATAP -0.84 0 NA
37 hsa-miR-93-5p AKT3 -0.61 0.8253 0.46 0.53933 miRNATAP -0.76 0 NA
38 hsa-let-7a-5p BCL2L1 -0.06 0.98501 0.24 0.89096 TargetScan; miRNATAP -0.27 0.0015 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
39 hsa-miR-106b-5p CBL -0.3 0.86929 0.1 0.93035 mirMAP -0.11 0.00124 NA
40 hsa-miR-542-3p CBL 0.19 0.90925 0.1 0.93035 miRNATAP -0.11 0.00537 NA
41 hsa-miR-582-3p CBL -0.23 0.89768 0.1 0.93035 mirMAP -0.12 0.00015 NA
42 hsa-miR-98-5p CBL -0.17 0.8988 0.1 0.93035 MirTarget -0.13 0.00205 NA
43 hsa-miR-29a-5p CBLB -0.32 0.60044 -0.14 0.89571 MirTarget -0.12 0.0002 NA
44 hsa-miR-335-3p CBLB -0.24 0.8845 -0.14 0.89571 mirMAP -0.16 0 NA
45 hsa-miR-421 CBLB -0.18 0.7347 -0.14 0.89571 miRanda -0.18 0 NA
46 hsa-miR-16-5p CCND1 0.01 0.99448 -0.25 0.89067 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.00823 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
47 hsa-miR-195-5p CCND1 0.34 0.74962 -0.25 0.89067 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.14 0.00272 21350001; 26631043; 25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein pā€‰=ā€‰0.013 pā€‰=ā€‰0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma
48 hsa-miR-29c-3p CCND1 0.16 0.94272 -0.25 0.89067 mirMAP -0.14 0.00181 NA
49 hsa-miR-30c-5p CLCF1 -0.3 0.86581 0.34 0.57176 miRNATAP -0.27 0.00212 NA
50 hsa-miR-30d-5p CLCF1 -0.17 0.95173 0.34 0.57176 miRNATAP -0.21 0.00611 NA
51 hsa-miR-362-3p CLCF1 -0.72 0.03459 0.34 0.57176 miRanda -0.14 0.00726 NA
52 hsa-miR-429 CLCF1 -0.46 0.80624 0.34 0.57176 miRanda; miRNATAP -0.2 4.0E-5 NA
53 hsa-miR-200b-3p CNTFR -0.43 0.86396 1.94 0.03267 TargetScan -0.59 0.00241 NA
54 hsa-miR-200c-3p CNTFR -0.44 0.88712 1.94 0.03267 miRNATAP -0.92 0 NA
55 hsa-miR-27b-5p CNTFR -0.33 0.68662 1.94 0.03267 miRNATAP -0.97 0.00073 NA
56 hsa-miR-493-5p CREBBP 0.23 0.73198 -0.07 0.96314 miRNATAP -0.13 0.00036 NA
57 hsa-miR-429 CSF2RA -0.46 0.80624 -0.35 0.50019 miRanda -0.38 0 NA
58 hsa-miR-590-3p CSF2RA -0.28 0.59127 -0.35 0.50019 mirMAP -0.39 1.0E-5 NA
59 hsa-miR-15b-3p CSF2RB -0.56 0.60918 -0.42 0.60801 mirMAP -0.56 0 NA
60 hsa-miR-186-5p CSF2RB -0.32 0.85413 -0.42 0.60801 mirMAP -0.53 0.00037 NA
61 hsa-miR-19a-3p CSF2RB -0.21 0.84464 -0.42 0.60801 MirTarget -0.51 0 NA
62 hsa-miR-19b-3p CSF2RB -0.03 0.98666 -0.42 0.60801 MirTarget -0.67 0 NA
63 hsa-miR-30b-3p CSF2RB -0.51 0.16242 -0.42 0.60801 MirTarget -0.43 2.0E-5 NA
64 hsa-miR-452-3p CSF2RB -0.17 0.79901 -0.42 0.60801 mirMAP -0.43 0 NA
65 hsa-miR-532-5p CSF2RB -0.35 0.87895 -0.42 0.60801 MirTarget -0.37 0.00041 NA
66 hsa-miR-576-5p CSF2RB -0.51 0.41719 -0.42 0.60801 miRNATAP -0.36 0.0007 NA
67 hsa-miR-590-3p CSF2RB -0.28 0.59127 -0.42 0.60801 miRanda; mirMAP -0.39 1.0E-5 NA
68 hsa-miR-625-5p CSF2RB -0.69 0.21031 -0.42 0.60801 MirTarget -0.29 0.00017 NA
69 hsa-miR-30b-3p CSF3R -0.51 0.16242 -0.47 0.47835 MirTarget -0.53 2.0E-5 NA
70 hsa-miR-361-5p CSF3R -0.14 0.9415 -0.47 0.47835 miRanda -0.62 0.00471 NA
71 hsa-miR-429 CSF3R -0.46 0.80624 -0.47 0.47835 miRanda -0.51 0 NA
72 hsa-miR-940 CSF3R -0.23 0.68006 -0.47 0.47835 MirTarget -0.35 0.00017 NA
73 hsa-miR-185-3p CTF1 0.1 0.85691 0.54 0.15973 MirTarget -0.32 0.00147 NA
74 hsa-miR-185-5p CTF1 -0.29 0.82059 0.54 0.15973 MirTarget -0.75 0 NA
75 hsa-miR-590-3p CTF1 -0.28 0.59127 0.54 0.15973 miRanda -0.46 0 NA
76 hsa-miR-940 CTF1 -0.23 0.68006 0.54 0.15973 MirTarget -0.24 0.00086 NA
77 hsa-miR-106b-5p EP300 -0.3 0.86929 -0.28 0.85828 miRNATAP -0.13 0.00096 NA
78 hsa-miR-26b-5p EP300 -0.02 0.99038 -0.28 0.85828 miRNAWalker2 validate; miRNATAP -0.12 0.00816 NA
79 hsa-miR-339-5p EP300 -0.3 0.71291 -0.28 0.85828 miRanda -0.11 0.00013 NA
80 hsa-miR-369-3p EP300 0.12 0.8323 -0.28 0.85828 MirTarget; PITA; miRNATAP -0.15 1.0E-5 NA
81 hsa-let-7f-5p GHR 0.05 0.98728 0.57 0.24502 miRNATAP -0.55 0.00308 NA
82 hsa-let-7g-5p GHR -0.2 0.92299 0.57 0.24502 miRNATAP -0.55 0.00375 NA
83 hsa-miR-142-3p GHR -0.15 0.9461 0.57 0.24502 MirTarget; PITA; miRanda; miRNATAP -0.26 0.00875 NA
84 hsa-miR-15a-5p GHR -0.07 0.96484 0.57 0.24502 MirTarget; miRNATAP -0.77 0 NA
85 hsa-miR-15b-5p GHR -0.27 0.87097 0.57 0.24502 MirTarget; miRNATAP -0.87 0 NA
86 hsa-miR-16-2-3p GHR -0.37 0.54685 0.57 0.24502 mirMAP -0.61 0 NA
87 hsa-miR-16-5p GHR 0.01 0.99448 0.57 0.24502 MirTarget; miRNATAP -0.81 0 NA
88 hsa-miR-29a-5p GHR -0.32 0.60044 0.57 0.24502 mirMAP; miRNATAP -0.41 0.00015 NA
89 hsa-miR-33a-3p GHR -0.79 0.01052 0.57 0.24502 miRNATAP -0.35 0.00056 NA
90 hsa-miR-429 GHR -0.46 0.80624 0.57 0.24502 miRanda; miRNATAP -0.39 4.0E-5 NA
91 hsa-miR-590-3p GHR -0.28 0.59127 0.57 0.24502 mirMAP -0.66 0 NA
92 hsa-miR-624-5p GHR -0.35 0.1906 0.57 0.24502 MirTarget -0.39 0.00109 NA
93 hsa-miR-7-1-3p GHR -0.46 0.6659 0.57 0.24502 MirTarget; mirMAP -0.69 0 NA
94 hsa-miR-106b-5p IFNAR2 -0.3 0.86929 0.05 0.95627 miRNAWalker2 validate -0.12 0.00026 NA
95 hsa-miR-181b-5p IFNGR1 0.16 0.93018 -0.01 0.99309 miRNAWalker2 validate -0.13 0.00809 NA
96 hsa-let-7d-5p IL10 -0.14 0.93416 0.17 0.79737 miRNATAP -0.64 0.00064 NA
97 hsa-let-7g-5p IL10 -0.2 0.92299 0.17 0.79737 miRNATAP -0.84 0 NA
98 hsa-miR-106a-5p IL10 -0.2 0.80221 0.17 0.79737 miRNAWalker2 validate -0.34 0.00303 NA
99 hsa-miR-27a-3p IL10 -0.12 0.9588 0.17 0.79737 miRNATAP -0.74 5.0E-5 NA
100 hsa-miR-27b-3p IL10 -0.14 0.95194 0.17 0.79737 miRNATAP -0.69 0.00125 NA
101 hsa-miR-32-3p IL10 -0.57 0.13133 0.17 0.79737 mirMAP -0.43 0 NA
102 hsa-miR-361-5p IL10 -0.14 0.9415 0.17 0.79737 MirTarget; PITA; miRanda; miRNATAP -0.61 0.00199 NA
103 hsa-miR-374b-5p IL10 -0.29 0.8357 0.17 0.79737 miRNATAP -0.76 0 NA
104 hsa-miR-421 IL10 -0.18 0.7347 0.17 0.79737 miRanda -0.31 0.00599 NA
105 hsa-miR-552-3p IL10 0.17 0.89397 0.17 0.79737 MirTarget -0.2 0.00035 NA
106 hsa-miR-590-3p IL10 -0.28 0.59127 0.17 0.79737 miRanda; mirMAP -0.38 6.0E-5 NA
107 hsa-miR-590-5p IL10 -0.55 0.47274 0.17 0.79737 miRanda -0.56 0 NA
108 hsa-miR-421 IL10RA -0.18 0.7347 -0.44 0.6221 miRanda -0.42 0 NA
109 hsa-miR-1275 IL12RB2 -0.83 0.08038 -0.08 0.87219 MirTarget -0.2 0.00161 NA
110 hsa-miR-339-5p IL12RB2 -0.3 0.71291 -0.08 0.87219 miRanda -0.31 0.00017 NA
111 hsa-miR-590-5p IL12RB2 -0.55 0.47274 -0.08 0.87219 miRanda -0.28 0.00139 NA
112 hsa-miR-192-5p IL15 -0.12 0.97293 -0.14 0.76461 miRNAWalker2 validate -0.15 0.00699 NA
113 hsa-miR-301a-3p IL15 -0.11 0.83169 -0.14 0.76461 MirTarget -0.2 0.00129 NA
114 hsa-miR-374b-5p IL15 -0.29 0.8357 -0.14 0.76461 MirTarget -0.26 0.00746 NA
115 hsa-miR-421 IL15 -0.18 0.7347 -0.14 0.76461 miRanda -0.25 0.00015 NA
116 hsa-miR-139-5p IL20RA -0.08 0.92869 -0.17 0.87503 miRanda -0.19 0.00166 NA
117 hsa-miR-24-2-5p IL21R -0.09 0.92016 -0.62 0.21852 MirTarget -0.45 0.00135 NA
118 hsa-miR-24-3p IL21R -0.05 0.98527 -0.62 0.21852 MirTarget -0.78 0.00045 NA
119 hsa-miR-335-5p IL21R -0.03 0.97338 -0.62 0.21852 miRNAWalker2 validate -0.66 0 NA
120 hsa-miR-421 IL21R -0.18 0.7347 -0.62 0.21852 miRanda -0.43 4.0E-5 NA
121 hsa-miR-335-3p IL22RA2 -0.24 0.8845 -0.72 0.41429 mirMAP -0.45 0.00014 NA
122 hsa-miR-125a-3p IL23R 0.15 0.72476 -0.31 0.5124 miRanda -0.27 0.00026 NA
123 hsa-miR-146b-5p IL23R -0.4 0.83751 -0.31 0.5124 miRanda -0.44 2.0E-5 NA
124 hsa-miR-330-5p IL23R -0.28 0.81569 -0.31 0.5124 miRanda -0.39 0.00147 NA
125 hsa-miR-224-3p IL2RA 0.11 0.74909 -0.42 0.41538 MirTarget -0.36 0.00023 NA
126 hsa-miR-500a-3p IL2RA -0.63 0.73258 -0.42 0.41538 MirTarget -0.35 0.0042 NA
127 hsa-miR-421 IL2RB -0.18 0.7347 -0.86 0.31394 mirMAP -0.29 0.00219 NA
128 hsa-miR-362-3p IL3RA -0.72 0.03459 0.16 0.80476 miRanda -0.17 0.0019 NA
129 hsa-miR-335-5p IL6 -0.03 0.97338 0.05 0.9359 miRNAWalker2 validate -0.52 0.00026 NA
130 hsa-miR-429 IL6 -0.46 0.80624 0.05 0.9359 miRanda -0.46 0.00018 NA
131 hsa-let-7g-5p IL6R -0.2 0.92299 0.14 0.82814 miRNATAP -0.5 0.00014 NA
132 hsa-miR-106b-5p IL6R -0.3 0.86929 0.14 0.82814 mirMAP -0.41 2.0E-5 NA
133 hsa-miR-130b-3p IL6R -0.22 0.82466 0.14 0.82814 mirMAP -0.38 1.0E-5 NA
134 hsa-miR-141-3p IL6R -0.32 0.87774 0.14 0.82814 MirTarget -0.26 0.00028 NA
135 hsa-miR-141-5p IL6R -0.35 0.86764 0.14 0.82814 MirTarget -0.22 0.00375 NA
136 hsa-miR-148a-5p IL6R -0.45 0.74842 0.14 0.82814 mirMAP -0.22 0.00845 NA
137 hsa-miR-17-5p IL6R -0.18 0.93454 0.14 0.82814 mirMAP -0.35 0 NA
138 hsa-miR-182-5p IL6R -0.1 0.97338 0.14 0.82814 mirMAP -0.28 0.00014 NA
139 hsa-miR-193b-3p IL6R 0.07 0.95148 0.14 0.82814 mirMAP -0.24 0.00257 NA
140 hsa-miR-200a-3p IL6R -0.37 0.85106 0.14 0.82814 MirTarget -0.2 0.00381 NA
141 hsa-miR-20a-5p IL6R -0.18 0.92812 0.14 0.82814 mirMAP -0.31 2.0E-5 NA
142 hsa-miR-29a-5p IL6R -0.32 0.60044 0.14 0.82814 mirMAP -0.26 0.00077 NA
143 hsa-miR-29b-1-5p IL6R -0.64 0.29389 0.14 0.82814 mirMAP -0.17 0.00553 NA
144 hsa-miR-30b-5p IL6R -0.01 0.99462 0.14 0.82814 mirMAP -0.26 0.00166 NA
145 hsa-miR-30c-5p IL6R -0.3 0.86581 0.14 0.82814 mirMAP -0.35 0.00346 NA
146 hsa-miR-331-3p IL6R -0.4 0.67059 0.14 0.82814 MirTarget -0.24 0.00805 NA
147 hsa-miR-335-5p IL6R -0.03 0.97338 0.14 0.82814 mirMAP -0.32 4.0E-5 NA
148 hsa-miR-33a-5p IL6R -0.21 0.85331 0.14 0.82814 mirMAP -0.17 0.00014 NA
149 hsa-miR-454-3p IL6R -0.1 0.84355 0.14 0.82814 mirMAP -0.32 0.00144 NA
150 hsa-miR-484 IL6R -0.18 0.88633 0.14 0.82814 MirTarget -0.29 0.00665 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE MEDIATED SIGNALING PATHWAY 41 452 6.664e-48 3.101e-44
2 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 58 1848 2.771e-45 6.446e-42
3 RESPONSE TO CYTOKINE 44 714 2.269e-44 3.52e-41
4 CELLULAR RESPONSE TO CYTOKINE STIMULUS 41 606 1.386e-42 1.612e-39
5 STAT CASCADE 19 50 1.879e-34 1.457e-31
6 JAK STAT CASCADE 19 50 1.879e-34 1.457e-31
7 REGULATION OF JAK STAT CASCADE 21 144 3.368e-28 1.959e-25
8 REGULATION OF STAT CASCADE 21 144 3.368e-28 1.959e-25
9 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 15 44 1.938e-26 1.002e-23
10 INTRACELLULAR SIGNAL TRANSDUCTION 41 1572 5.654e-26 2.631e-23
11 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 14 37 1.714e-25 7.25e-23
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 41 1656 4.22e-25 1.636e-22
13 POSITIVE REGULATION OF STAT CASCADE 16 73 1.235e-24 4.105e-22
14 POSITIVE REGULATION OF JAK STAT CASCADE 16 73 1.235e-24 4.105e-22
15 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN 15 68 3.494e-23 1.084e-20
16 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 1.724e-20 5.014e-18
17 REGULATION OF PHOSPHORUS METABOLIC PROCESS 35 1618 5.082e-19 1.391e-16
18 PHOSPHORYLATION 31 1228 1.548e-18 4.001e-16
19 REGULATION OF IMMUNE RESPONSE 27 858 2.064e-18 5.055e-16
20 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 17 213 2.636e-18 6.133e-16
21 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 27 876 3.492e-18 7.737e-16
22 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 9 20 1.45e-17 3.066e-15
23 PROTEIN PHOSPHORYLATION 27 944 2.297e-17 4.647e-15
24 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 24 689 2.597e-17 5.036e-15
25 RESPONSE TO HORMONE 26 893 6.909e-17 1.236e-14
26 REGULATION OF IMMUNE SYSTEM PROCESS 31 1403 6.785e-17 1.236e-14
27 RESPONSE TO ENDOGENOUS STIMULUS 31 1450 1.711e-16 2.949e-14
28 REGULATION OF PROTEIN MODIFICATION PROCESS 33 1710 2.453e-16 4.077e-14
29 PEPTIDYL TYROSINE MODIFICATION 15 186 2.665e-16 4.276e-14
30 IMMUNE SYSTEM PROCESS 35 1984 3.145e-16 4.878e-14
31 REGULATION OF KINASE ACTIVITY 24 776 3.786e-16 5.683e-14
32 RESPONSE TO PEPTIDE 19 404 4.237e-16 6.161e-14
33 CELLULAR RESPONSE TO HORMONE STIMULUS 21 552 6.558e-16 9.247e-14
34 POSITIVE REGULATION OF CELL PROLIFERATION 24 814 1.101e-15 1.464e-13
35 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 14 162 1.083e-15 1.464e-13
36 RESPONSE TO GROWTH HORMONE 9 30 1.199e-15 1.549e-13
37 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 26 1008 1.266e-15 1.592e-13
38 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 20 498 1.302e-15 1.594e-13
39 REGULATION OF DEFENSE RESPONSE 23 759 2.788e-15 3.326e-13
40 RESPONSE TO NITROGEN COMPOUND 24 859 3.639e-15 4.233e-13
41 RESPONSE TO OXYGEN CONTAINING COMPOUND 29 1381 3.737e-15 4.241e-13
42 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 23 799 8.333e-15 9.232e-13
43 REGULATION OF CELL DEATH 29 1472 1.95e-14 2.111e-12
44 REGULATION OF TRANSFERASE ACTIVITY 24 946 3.042e-14 3.217e-12
45 JAK STAT CASCADE INVOLVED IN GROWTH HORMONE SIGNALING PATHWAY 7 15 4.916e-14 5.083e-12
46 NEGATIVE REGULATION OF CELL DEATH 23 872 5.294e-14 5.355e-12
47 POSITIVE REGULATION OF CELL COMMUNICATION 29 1532 5.443e-14 5.388e-12
48 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 32 1977 1.211e-13 1.174e-11
49 LYMPHOCYTE ACTIVATION 16 342 1.292e-13 1.227e-11
50 REGULATION OF RESPONSE TO STRESS 28 1468 1.451e-13 1.351e-11
51 CELL ACTIVATION 19 568 1.992e-13 1.818e-11
52 REGULATION OF CELL PROLIFERATION 28 1496 2.312e-13 2.069e-11
53 CELLULAR RESPONSE TO NITROGEN COMPOUND 18 505 3.262e-13 2.864e-11
54 REGULATION OF HOMOTYPIC CELL CELL ADHESION 15 307 4.381e-13 3.775e-11
55 TYROSINE PHOSPHORYLATION OF STAT PROTEIN 6 10 4.705e-13 3.98e-11
56 POSITIVE REGULATION OF CELL ACTIVATION 15 311 5.284e-13 4.39e-11
57 REGULATION OF CELL CELL ADHESION 16 380 6.497e-13 5.304e-11
58 CELLULAR RESPONSE TO PEPTIDE 14 274 1.565e-12 1.256e-10
59 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 27 1492 1.605e-12 1.266e-10
60 REGULATION OF CELL ACTIVATION 17 484 2.065e-12 1.602e-10
61 LEUKOCYTE ACTIVATION 16 414 2.388e-12 1.822e-10
62 REGULATION OF INFLAMMATORY RESPONSE 14 294 4.056e-12 3.044e-10
63 POSITIVE REGULATION OF CELL CELL ADHESION 13 243 5.924e-12 4.375e-10
64 REGULATION OF HEMOPOIESIS 14 314 9.818e-12 7.138e-10
65 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 23 1135 1.226e-11 8.778e-10
66 REGULATION OF CELL ADHESION 18 629 1.281e-11 9.031e-10
67 LEUKOCYTE MIGRATION 13 259 1.322e-11 9.183e-10
68 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 22 1036 1.556e-11 1.049e-09
69 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 22 1036 1.556e-11 1.049e-09
70 LYMPHOCYTE DIFFERENTIATION 12 209 1.812e-11 1.204e-09
71 PEPTIDYL AMINO ACID MODIFICATION 20 841 2.154e-11 1.411e-09
72 NEGATIVE REGULATION OF CELL COMMUNICATION 23 1192 3.294e-11 2.129e-09
73 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 20 867 3.715e-11 2.368e-09
74 REGULATION OF LEUKOCYTE DIFFERENTIATION 12 232 6.124e-11 3.851e-09
75 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 24 1360 6.947e-11 4.31e-09
76 REGULATION OF CELL DIFFERENTIATION 25 1492 7.428e-11 4.547e-09
77 POSITIVE REGULATION OF CELL ADHESION 14 376 1.075e-10 6.494e-09
78 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 24 1395 1.173e-10 6.996e-09
79 REGULATION OF T CELL PROLIFERATION 10 147 1.862e-10 1.097e-08
80 REGULATION OF T CELL DIFFERENTIATION 9 107 2.388e-10 1.389e-08
81 REGULATION OF LEUKOCYTE PROLIFERATION 11 206 2.917e-10 1.676e-08
82 REGULATION OF RESPONSE TO WOUNDING 14 413 3.674e-10 2.085e-08
83 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 5.93e-10 3.324e-08
84 POSITIVE REGULATION OF MOLECULAR FUNCTION 26 1791 6.287e-10 3.482e-08
85 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 14 437 7.653e-10 4.189e-08
86 RESPONSE TO ALCOHOL 13 362 8.311e-10 4.497e-08
87 LEUKOCYTE DIFFERENTIATION 12 292 8.62e-10 4.61e-08
88 POSITIVE REGULATION OF CYTOKINE PRODUCTION 13 370 1.084e-09 5.732e-08
89 CELL MOTILITY 18 835 1.258e-09 6.503e-08
90 LOCALIZATION OF CELL 18 835 1.258e-09 6.503e-08
91 REGULATION OF LYMPHOCYTE DIFFERENTIATION 9 132 1.568e-09 8.02e-08
92 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 9 136 2.045e-09 1.034e-07
93 REGULATION OF CYTOKINE PRODUCTION 15 563 2.205e-09 1.103e-07
94 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 7 59 2.286e-09 1.131e-07
95 POSITIVE REGULATION OF T CELL PROLIFERATION 8 95 2.495e-09 1.222e-07
96 RESPONSE TO LIPID 18 888 3.32e-09 1.609e-07
97 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 9 144 3.391e-09 1.627e-07
98 IMMUNE SYSTEM DEVELOPMENT 15 582 3.456e-09 1.641e-07
99 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 24 1672 4.526e-09 2.124e-07
100 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 20 1142 4.565e-09 2.124e-07
101 RESPONSE TO INSULIN 10 205 4.772e-09 2.198e-07
102 NEGATIVE REGULATION OF PHOSPHORYLATION 13 422 5.285e-09 2.411e-07
103 RESPONSE TO ORGANIC CYCLIC COMPOUND 18 917 5.488e-09 2.479e-07
104 REGULATION OF INNATE IMMUNE RESPONSE 12 357 8.285e-09 3.707e-07
105 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 8 113 9.953e-09 4.411e-07
106 POSITIVE REGULATION OF HEMOPOIESIS 9 163 1.008e-08 4.423e-07
107 REGULATION OF GROWTH 15 633 1.068e-08 4.643e-07
108 GLUCOSE HOMEOSTASIS 9 170 1.454e-08 6.208e-07
109 CARBOHYDRATE HOMEOSTASIS 9 170 1.454e-08 6.208e-07
110 IMMUNE RESPONSE 19 1100 1.516e-08 6.414e-07
111 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 1.601e-08 6.709e-07
112 REGULATION OF RESPONSE TO INTERFERON GAMMA 5 22 1.623e-08 6.741e-07
113 REGULATION OF MAPK CASCADE 15 660 1.861e-08 7.663e-07
114 POSITIVE REGULATION OF IMMUNE RESPONSE 14 563 1.933e-08 7.889e-07
115 POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 7 80 1.999e-08 8.09e-07
116 POSITIVE REGULATION OF CATALYTIC ACTIVITY 22 1518 2.049e-08 8.218e-07
117 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 23 2.067e-08 8.222e-07
118 CELL PROLIFERATION 15 672 2.362e-08 9.315e-07
119 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 8 131 3.189e-08 1.247e-06
120 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 3.245e-08 1.258e-06
121 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 17 926 4.2e-08 1.615e-06
122 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 138 4.789e-08 1.827e-06
123 REGULATION OF IMMUNE EFFECTOR PROCESS 12 424 5.52e-08 2.088e-06
124 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 55 5.684e-08 2.133e-06
125 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 5 28 5.951e-08 2.215e-06
126 RESPONSE TO ESTRADIOL 8 146 7.425e-08 2.742e-06
127 LIPID PHOSPHORYLATION 7 99 8.854e-08 3.219e-06
128 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 8.824e-08 3.219e-06
129 DEFENSE RESPONSE 19 1231 9.07e-08 3.272e-06
130 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 541 9.825e-08 3.49e-06
131 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 13 541 9.825e-08 3.49e-06
132 LOCOMOTION 18 1114 1.079e-07 3.803e-06
133 RESPONSE TO EXTERNAL STIMULUS 23 1821 1.133e-07 3.964e-06
134 RESPONSE TO ESTROGEN 9 218 1.24e-07 4.306e-06
135 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 19 1275 1.57e-07 5.412e-06
136 POSITIVE REGULATION OF RESPONSE TO WOUNDING 8 162 1.659e-07 5.675e-06
137 REGULATION OF MULTICELLULAR ORGANISM GROWTH 6 66 1.725e-07 5.857e-06
138 HOMEOSTASIS OF NUMBER OF CELLS 8 175 2.998e-07 1.011e-05
139 RESPONSE TO STEROID HORMONE 12 497 3.065e-07 1.019e-05
140 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 11 404 3.065e-07 1.019e-05
141 HOMEOSTATIC PROCESS 19 1337 3.272e-07 1.077e-05
142 POSITIVE REGULATION OF CELL DIFFERENTIATION 15 823 3.287e-07 1.077e-05
143 REGULATION OF TYPE I INTERFERON MEDIATED SIGNALING PATHWAY 5 39 3.376e-07 1.098e-05
144 NEGATIVE REGULATION OF KINASE ACTIVITY 9 250 3.951e-07 1.259e-05
145 REGULATION OF ADAPTIVE IMMUNE RESPONSE 7 123 3.933e-07 1.259e-05
146 T CELL DIFFERENTIATION 7 123 3.933e-07 1.259e-05
147 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 4.183e-07 1.306e-05
148 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 17 1087 4.141e-07 1.306e-05
149 INOSITOL LIPID MEDIATED SIGNALING 7 124 4.156e-07 1.306e-05
150 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 616 4.34e-07 1.346e-05
151 LEUKOCYTE CELL CELL ADHESION 9 255 4.665e-07 1.438e-05
152 ERBB SIGNALING PATHWAY 6 79 5.077e-07 1.554e-05
153 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 5.436e-07 1.653e-05
154 INSULIN RECEPTOR SIGNALING PATHWAY 6 80 5.472e-07 1.653e-05
155 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 983 5.703e-07 1.712e-05
156 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 6.314e-07 1.848e-05
157 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 5 44 6.276e-07 1.848e-05
158 B CELL ACTIVATION 7 132 6.353e-07 1.848e-05
159 NEGATIVE REGULATION OF JAK STAT CASCADE 5 44 6.276e-07 1.848e-05
160 NEGATIVE REGULATION OF STAT CASCADE 5 44 6.276e-07 1.848e-05
161 REGULATION OF ERBB SIGNALING PATHWAY 6 83 6.813e-07 1.969e-05
162 RESPONSE TO BIOTIC STIMULUS 15 886 8.355e-07 2.4e-05
163 RESPONSE TO LEPTIN 4 20 8.443e-07 2.41e-05
164 POSITIVE REGULATION OF DEFENSE RESPONSE 10 364 1.022e-06 2.899e-05
165 LIPID MODIFICATION 8 210 1.193e-06 3.365e-05
166 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 1.237e-06 3.466e-05
167 CELLULAR RESPONSE TO INTERLEUKIN 6 4 22 1.268e-06 3.532e-05
168 REGULATION OF HYDROLASE ACTIVITY 18 1327 1.406e-06 3.894e-05
169 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 218 1.579e-06 4.348e-05
170 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 296 1.611e-06 4.41e-05
171 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 220 1.691e-06 4.601e-05
172 MYELOID LEUKOCYTE MIGRATION 6 99 1.929e-06 5.218e-05
173 NATURAL KILLER CELL ACTIVATION 5 55 1.947e-06 5.223e-05
174 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 7 156 1.953e-06 5.223e-05
175 REGULATION OF T HELPER CELL DIFFERENTIATION 4 26 2.561e-06 6.766e-05
176 RESPONSE TO INTERLEUKIN 6 4 26 2.561e-06 6.766e-05
177 POSITIVE REGULATION OF PROTEIN IMPORT 6 104 2.574e-06 6.766e-05
178 REGULATION OF BODY FLUID LEVELS 11 506 2.77e-06 7.199e-05
179 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 2.763e-06 7.199e-05
180 REGULATION OF GLUCOSE IMPORT 5 60 3.012e-06 7.659e-05
181 REGULATION OF NATURAL KILLER CELL ACTIVATION 4 27 2.998e-06 7.659e-05
182 GROWTH 10 410 2.97e-06 7.659e-05
183 LEUKOCYTE HOMEOSTASIS 5 60 3.012e-06 7.659e-05
184 POSITIVE REGULATION OF ACTIVATED T CELL PROLIFERATION 4 28 3.488e-06 8.82e-05
185 NEGATIVE REGULATION OF NEURON DEATH 7 171 3.595e-06 9.042e-05
186 REGULATION OF CELL KILLING 5 63 3.843e-06 9.613e-05
187 CHEMICAL HOMEOSTASIS 14 874 3.903e-06 9.71e-05
188 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 6 114 4.392e-06 0.0001087
189 LEUKOCYTE CHEMOTAXIS 6 117 5.105e-06 0.0001257
190 RESPONSE TO TYPE I INTERFERON 5 68 5.617e-06 0.0001363
191 REGULATION OF MYELOID CELL DIFFERENTIATION 7 183 5.623e-06 0.0001363
192 REGULATION OF PROTEIN IMPORT 7 183 5.623e-06 0.0001363
193 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 121 6.2e-06 0.0001495
194 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 6.462e-06 0.0001547
195 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 5 70 6.483e-06 0.0001547
196 REGULATION OF GTPASE ACTIVITY 12 673 7.169e-06 0.0001702
197 INFLAMMATORY RESPONSE 10 454 7.297e-06 0.0001723
198 OXALOACETATE METABOLIC PROCESS 3 11 8.179e-06 0.0001912
199 CREATINE METABOLIC PROCESS 3 11 8.179e-06 0.0001912
200 REGULATION OF ACUTE INFLAMMATORY RESPONSE 5 74 8.529e-06 0.0001974
201 NEGATIVE REGULATION OF HORMONE SECRETION 5 74 8.529e-06 0.0001974
202 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 8.993e-06 0.0002071
203 NEGATIVE REGULATION OF MOLECULAR FUNCTION 15 1079 9.352e-06 0.0002144
204 POSITIVE REGULATION OF MAPK CASCADE 10 470 9.87e-06 0.000224
205 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 470 9.87e-06 0.000224
206 NATURAL KILLER CELL DIFFERENTIATION 3 12 1.088e-05 0.0002433
207 RESPONSE TO GROWTH FACTOR 10 475 1.082e-05 0.0002433
208 POSITIVE REGULATION OF ASTROCYTE DIFFERENTIATION 3 12 1.088e-05 0.0002433
209 REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 4 38 1.222e-05 0.0002721
210 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 1.228e-05 0.0002721
211 REGULATION OF DEVELOPMENTAL GROWTH 8 289 1.259e-05 0.0002775
212 IMMUNE EFFECTOR PROCESS 10 486 1.319e-05 0.0002896
213 POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 13 1.41e-05 0.0003066
214 ENERGY HOMEOSTASIS 3 13 1.41e-05 0.0003066
215 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 1.505e-05 0.0003226
216 REGULATION OF ACTIVATED T CELL PROLIFERATION 4 40 1.505e-05 0.0003226
217 POSITIVE REGULATION OF CELL DEATH 11 605 1.5e-05 0.0003226
218 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 1.533e-05 0.0003272
219 PLATELET ACTIVATION 6 142 1.551e-05 0.0003296
220 LACTATION 4 41 1.663e-05 0.0003516
221 RESPONSE TO INTERFERON GAMMA 6 144 1.679e-05 0.0003536
222 NEGATIVE REGULATION OF MAPK CASCADE 6 145 1.747e-05 0.0003661
223 CELLULAR RESPONSE TO INSULIN STIMULUS 6 146 1.816e-05 0.000379
224 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 1.832e-05 0.0003806
225 INNATE IMMUNE RESPONSE 11 619 1.854e-05 0.0003833
226 MYELOID LEUKOCYTE MEDIATED IMMUNITY 4 43 2.015e-05 0.000413
227 ACUTE PHASE RESPONSE 4 43 2.015e-05 0.000413
228 NEGATIVE REGULATION OF CELL ADHESION 7 223 2.034e-05 0.0004151
229 B CELL DIFFERENTIATION 5 89 2.104e-05 0.0004275
230 REPRODUCTIVE SYSTEM DEVELOPMENT 9 408 2.142e-05 0.0004334
231 LIPID METABOLIC PROCESS 15 1158 2.156e-05 0.0004344
232 REGULATION OF MAP KINASE ACTIVITY 8 319 2.559e-05 0.0005133
233 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 2.642e-05 0.0005231
234 REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 4 46 2.641e-05 0.0005231
235 NEGATIVE REGULATION OF CELL PROLIFERATION 11 643 2.631e-05 0.0005231
236 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 8 321 2.676e-05 0.0005276
237 NEGATIVE REGULATION OF CHEMOKINE PRODUCTION 3 16 2.739e-05 0.0005309
238 CELLULAR RESPONSE TO LEPTIN STIMULUS 3 16 2.739e-05 0.0005309
239 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 3 16 2.739e-05 0.0005309
240 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN 3 16 2.739e-05 0.0005309
241 HORMONE MEDIATED SIGNALING PATHWAY 6 158 2.838e-05 0.000548
242 POSITIVE REGULATION OF HYDROLASE ACTIVITY 13 905 2.865e-05 0.0005508
243 RESPONSE TO ANTIBIOTIC 4 47 2.879e-05 0.0005513
244 REGULATION OF LIPID KINASE ACTIVITY 4 48 3.132e-05 0.0005962
245 CELLULAR LIPID METABOLIC PROCESS 13 913 3.139e-05 0.0005962
246 CELL CHEMOTAXIS 6 162 3.267e-05 0.0006179
247 LYMPHOCYTE HOMEOSTASIS 4 50 3.686e-05 0.0006878
248 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 5 100 3.696e-05 0.0006878
249 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 100 3.696e-05 0.0006878
250 REGULATION OF GLUCOSE TRANSPORT 5 100 3.696e-05 0.0006878
251 REGULATION OF CELLULAR PROTEIN LOCALIZATION 10 552 3.914e-05 0.0007227
252 RESPONSE TO VIRUS 7 247 3.91e-05 0.0007227
253 POSITIVE REGULATION OF T HELPER CELL DIFFERENTIATION 3 18 3.969e-05 0.0007271
254 POSITIVE REGULATION OF NATURAL KILLER CELL ACTIVATION 3 18 3.969e-05 0.0007271
255 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 5 102 4.065e-05 0.0007417
256 REGULATION OF NEURON DEATH 7 252 4.44e-05 0.000807
257 REGULATION OF LEUKOCYTE MEDIATED CYTOTOXICITY 4 53 4.647e-05 0.0008413
258 SINGLE ORGANISM CELL ADHESION 9 459 5.362e-05 0.000967
259 POSITIVE REGULATION OF GENE EXPRESSION 18 1733 5.504e-05 0.0009832
260 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 3 20 5.515e-05 0.0009832
261 X2 OXOGLUTARATE METABOLIC PROCESS 3 20 5.515e-05 0.0009832
262 GLYCEROLIPID METABOLIC PROCESS 8 356 5.565e-05 0.0009883
263 RESPONSE TO KETONE 6 182 6.257e-05 0.001107
264 REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 21 6.417e-05 0.001131
265 PHOSPHOLIPID METABOLIC PROCESS 8 364 6.502e-05 0.001142
266 CELLULAR RESPONSE TO ALCOHOL 5 115 7.212e-05 0.001262
267 REGULATION OF T HELPER 1 TYPE IMMUNE RESPONSE 3 22 7.41e-05 0.001291
268 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 60 7.586e-05 0.001312
269 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 8 372 7.567e-05 0.001312
270 MAMMARY GLAND DEVELOPMENT 5 117 7.828e-05 0.001349
271 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 8.025e-05 0.001378
272 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 8.096e-05 0.00138
273 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 8.077e-05 0.00138
274 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1004 8.308e-05 0.001411
275 REGULATION OF METANEPHROS DEVELOPMENT 3 23 8.499e-05 0.001433
276 BRANCHED CHAIN AMINO ACID METABOLIC PROCESS 3 23 8.499e-05 0.001433
277 REGULATION OF TISSUE REMODELING 4 62 8.629e-05 0.00145
278 CELL CELL ADHESION 10 608 8.767e-05 0.001467
279 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 8 381 8.935e-05 0.00149
280 REGULATION OF LIPID METABOLIC PROCESS 7 282 9.004e-05 0.001496
281 NEGATIVE REGULATION OF IMMUNE RESPONSE 5 121 9.18e-05 0.00152
282 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 5 122 9.545e-05 0.001569
283 CELLULAR RESPONSE TO INTERFERON GAMMA 5 122 9.545e-05 0.001569
284 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 9.765e-05 0.0016
285 REGULATION OF CHEMOKINE PRODUCTION 4 65 0.0001038 0.00169
286 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 65 0.0001038 0.00169
287 NEGATIVE REGULATION OF SECRETION 6 200 0.0001053 0.001707
288 CELLULAR EXTRAVASATION 3 25 0.0001098 0.001774
289 CELLULAR RESPONSE TO UV 4 66 0.0001102 0.001775
290 RESPONSE TO UV 5 126 0.0001112 0.001783
291 REGULATION OF SYSTEM PROCESS 9 507 0.0001145 0.001821
292 GLAND DEVELOPMENT 8 395 0.0001147 0.001821
293 NEGATIVE REGULATION OF CATABOLIC PROCESS 6 203 0.0001142 0.001821
294 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 0.0001197 0.001895
295 REGULATION OF ALPHA BETA T CELL ACTIVATION 4 68 0.0001239 0.001939
296 ORGAN GROWTH 4 68 0.0001239 0.001939
297 NUCLEAR IMPORT 5 129 0.0001242 0.001939
298 CELLULAR RESPONSE TO VITAMIN 3 26 0.0001238 0.001939
299 REGULATION OF ASTROCYTE DIFFERENTIATION 3 27 0.0001389 0.002154
300 POSITIVE REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 3 27 0.0001389 0.002154
301 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 6 211 0.0001411 0.002181
302 BODY FLUID SECRETION 4 71 0.0001465 0.002258
303 REGULATION OF PROTEIN TARGETING 7 307 0.0001524 0.002341
304 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 0.0001537 0.002353
305 ENERGY RESERVE METABOLIC PROCESS 4 72 0.0001547 0.00236
306 RESPONSE TO BACTERIUM 9 528 0.0001554 0.002364
307 RESPONSE TO ETHANOL 5 136 0.0001591 0.002412
308 POSITIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 4 73 0.0001632 0.002458
309 ACUTE INFLAMMATORY RESPONSE 4 73 0.0001632 0.002458
310 CELLULAR RESPONSE TO RADIATION 5 137 0.0001647 0.00247
311 HEMOSTASIS 7 311 0.0001651 0.00247
312 NEGATIVE REGULATION OF CELL CELL ADHESION 5 138 0.0001704 0.002541
313 POSITIVE REGULATION OF TRANSPORT 12 936 0.0001766 0.002626
314 CELLULAR GLUCOSE HOMEOSTASIS 4 75 0.0001812 0.002679
315 LIPID BIOSYNTHETIC PROCESS 9 539 0.0001813 0.002679
316 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 11 801 0.0001872 0.002757
317 REGULATION OF CELL CYCLE 12 949 0.0002007 0.002946
318 NEGATIVE REGULATION OF DEFENSE RESPONSE 5 144 0.0002078 0.003036
319 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 7 323 0.0002081 0.003036
320 POSITIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 32 0.0002323 0.003378
321 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 0.0002439 0.003535
322 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 11 829 0.0002519 0.00364
323 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 82 0.0002557 0.003683
324 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 0.000267 0.003835
325 ORGAN REGENERATION 4 83 0.0002679 0.003835
326 REGULATION OF PROTEIN DEACETYLATION 3 34 0.0002788 0.003955
327 T CELL HOMEOSTASIS 3 34 0.0002788 0.003955
328 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 0.0002785 0.003955
329 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 84 0.0002805 0.003967
330 PROTEIN IMPORT 5 155 0.0002922 0.004121
331 POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS 5 156 0.0003011 0.004207
332 PROTEIN LOCALIZATION TO NUCLEUS 5 156 0.0003011 0.004207
333 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 5 156 0.0003011 0.004207
334 CELLULAR RESPONSE TO LIPID 8 457 0.0003089 0.004303
335 NEGATIVE REGULATION OF BLOOD CIRCULATION 3 36 0.0003308 0.004595
336 LEUKOCYTE PROLIFERATION 4 88 0.0003351 0.004627
337 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 88 0.0003351 0.004627
338 REGENERATION 5 161 0.0003481 0.004792
339 TRICARBOXYLIC ACID METABOLIC PROCESS 3 37 0.0003591 0.004914
340 POSITIVE REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 3 37 0.0003591 0.004914
341 CELLULAR RESPONSE TO LIGHT STIMULUS 4 91 0.0003809 0.005197
342 REGULATION OF CATABOLIC PROCESS 10 731 0.0003878 0.005259
343 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 38 0.0003888 0.005259
344 REGULATION OF GLUCONEOGENESIS 3 38 0.0003888 0.005259
345 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 0.0004011 0.005403
346 RESPONSE TO ABIOTIC STIMULUS 12 1024 0.0004018 0.005403
347 MORPHOGENESIS OF A BRANCHING STRUCTURE 5 167 0.0004117 0.005521
348 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 258 0.000416 0.005537
349 REGULATION OF HORMONE LEVELS 8 478 0.0004167 0.005537
350 ERBB2 SIGNALING PATHWAY 3 39 0.0004201 0.005537
351 ASTROCYTE DIFFERENTIATION 3 39 0.0004201 0.005537
352 CELLULAR RESPONSE TO NUTRIENT 3 39 0.0004201 0.005537
353 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 0.0004201 0.005537
354 REGULATION OF CYTOPLASMIC TRANSPORT 8 481 0.0004344 0.005709
355 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 365 0.0004356 0.005709
356 TISSUE DEVELOPMENT 15 1518 0.0004429 0.005788
357 NEGATIVE REGULATION OF CELL DIFFERENTIATION 9 609 0.0004448 0.005797
358 REGULATION OF HORMONE SECRETION 6 262 0.0004513 0.005865
359 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 0.0004711 0.006106
360 POSITIVE REGULATION OF SECRETION 7 370 0.0004724 0.006106
361 SEX DIFFERENTIATION 6 266 0.0004889 0.006301
362 RESPONSE TO VITAMIN 4 98 0.0005047 0.006487
363 RESPONSE TO CORTICOSTEROID 5 176 0.0005231 0.006686
364 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 99 0.0005245 0.006686
365 REGULATION OF BONE REMODELING 3 42 0.0005234 0.006686
366 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 43 0.0005612 0.007076
367 DEFENSE RESPONSE TO GRAM NEGATIVE BACTERIUM 3 43 0.0005612 0.007076
368 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 0.0005612 0.007076
369 REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 3 43 0.0005612 0.007076
370 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 101 0.0005657 0.007114
371 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 6 274 0.0005714 0.007166
372 NEGATIVE REGULATION OF HOMOTYPIC CELL CELL ADHESION 4 102 0.0005871 0.007343
373 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 0.0006282 0.007836
374 REGULATION OF INTERLEUKIN 6 PRODUCTION 4 104 0.0006317 0.007859
375 NEUROGENESIS 14 1402 0.0006377 0.007912
376 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 6 282 0.0006643 0.008221
377 REGULATION OF EPITHELIAL CELL PROLIFERATION 6 285 0.000702 0.008664
378 REGULATION OF IMMUNOGLOBULIN PRODUCTION 3 47 0.0007294 0.008932
379 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0007279 0.008932
380 POSITIVE REGULATION OF GLIOGENESIS 3 47 0.0007294 0.008932
381 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN 2 11 0.0007466 0.009071
382 REGULATION OF T HELPER 2 CELL DIFFERENTIATION 2 11 0.0007466 0.009071
383 BRANCHING INVOLVED IN LABYRINTHINE LAYER MORPHOGENESIS 2 11 0.0007466 0.009071
384 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 0.0007549 0.009147
385 EPITHELIUM DEVELOPMENT 11 945 0.000758 0.009162
386 REGULATION OF ENDOCRINE PROCESS 3 48 0.000776 0.00933
387 REGULATION OF NEURON APOPTOTIC PROCESS 5 192 0.0007754 0.00933
388 INTERSPECIES INTERACTION BETWEEN ORGANISMS 9 662 0.0008082 0.009667
389 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 9 662 0.0008082 0.009667
390 REGULATION OF OSTEOBLAST DIFFERENTIATION 4 112 0.0008342 0.009952
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE RECEPTOR ACTIVITY 23 89 3.693e-37 3.431e-34
2 CYTOKINE RECEPTOR BINDING 19 271 2.48e-19 1.152e-16
3 CYTOKINE BINDING 13 92 1.717e-17 5.317e-15
4 RECEPTOR BINDING 32 1476 3.005e-17 6.98e-15
5 SIGNAL TRANSDUCER ACTIVITY 32 1731 2.916e-15 5.417e-13
6 KINASE REGULATOR ACTIVITY 13 186 1.953e-13 3.024e-11
7 MOLECULAR FUNCTION REGULATOR 25 1353 9.015e-12 1.196e-09
8 KINASE ACTIVITY 19 842 1.84e-10 2.104e-08
9 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 2.265e-10 2.104e-08
10 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 2.088e-10 2.104e-08
11 KINASE BINDING 16 606 6.762e-10 5.571e-08
12 SIGNALING RECEPTOR ACTIVITY 23 1393 7.197e-10 5.571e-08
13 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 7.944e-10 5.677e-08
14 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 19 992 2.825e-09 1.874e-07
15 HORMONE RECEPTOR BINDING 9 168 1.312e-08 7.667e-07
16 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 10 228 1.32e-08 7.667e-07
17 RECEPTOR ACTIVITY 23 1649 1.812e-08 9.9e-07
18 GROWTH FACTOR BINDING 8 123 1.944e-08 1.003e-06
19 KINASE INHIBITOR ACTIVITY 7 89 4.222e-08 2.064e-06
20 ENZYME BINDING 23 1737 4.765e-08 2.213e-06
21 INSULIN RECEPTOR SUBSTRATE BINDING 4 11 5.9e-08 2.61e-06
22 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 10 303 1.908e-07 8.058e-06
23 PROTEIN TYROSINE KINASE ACTIVITY 8 176 3.131e-07 1.265e-05
24 GROWTH FACTOR RECEPTOR BINDING 7 129 5.436e-07 2.104e-05
25 PROTEIN KINASE ACTIVITY 13 640 6.679e-07 2.482e-05
26 CYTOKINE ACTIVITY 8 219 1.634e-06 5.839e-05
27 ENZYME REGULATOR ACTIVITY 15 959 2.236e-06 7.694e-05
28 PHOSPHATASE BINDING 7 162 2.512e-06 8.333e-05
29 PROTEIN PHOSPHATASE BINDING 6 120 5.91e-06 0.0001893
30 GLUCOCORTICOID RECEPTOR BINDING 3 14 1.79e-05 0.0005542
31 PROTEIN DIMERIZATION ACTIVITY 15 1149 1.968e-05 0.0005898
32 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 2.739e-05 0.000795
33 GROWTH FACTOR ACTIVITY 6 160 3.047e-05 0.0008577
34 PEPTIDE HORMONE RECEPTOR BINDING 3 17 3.316e-05 0.0009062
35 PROTEIN TYROSINE KINASE BINDING 4 54 5.004e-05 0.001328
36 STEROID HORMONE RECEPTOR BINDING 4 81 0.0002439 0.006294
37 PEPTIDE HORMONE BINDING 3 36 0.0003308 0.008307
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 5.834e-13 3.407e-10
2 EXTRINSIC COMPONENT OF MEMBRANE 11 252 2.458e-09 7.178e-07
3 RECEPTOR COMPLEX 10 327 3.85e-07 7.495e-05
4 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 8 237 2.943e-06 0.0004296
5 PLASMA MEMBRANE RECEPTOR COMPLEX 7 175 4.189e-06 0.0004626
6 MEMBRANE PROTEIN COMPLEX 15 1020 4.752e-06 0.0004626
7 SIDE OF MEMBRANE 9 428 3.117e-05 0.002601
8 EXTRACELLULAR SPACE 16 1376 4.105e-05 0.002997
9 INTRINSIC COMPONENT OF PLASMA MEMBRANE 17 1649 0.0001019 0.006612
10 CELL SURFACE 11 757 0.0001142 0.006672

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04630_Jak.STAT_signaling_pathway 75 155 2.035e-168 3.663e-166
2 hsa04151_PI3K_AKT_signaling_pathway 28 351 3.499e-30 3.149e-28
3 hsa04012_ErbB_signaling_pathway 15 87 1.965e-21 1.179e-19
4 hsa04380_Osteoclast_differentiation 15 128 8.786e-19 3.954e-17
5 hsa04910_Insulin_signaling_pathway 15 138 2.814e-18 1.013e-16
6 hsa04062_Chemokine_signaling_pathway 16 189 1.117e-17 3.352e-16
7 hsa04660_T_cell_receptor_signaling_pathway 13 108 1.512e-16 3.888e-15
8 hsa04210_Apoptosis 11 89 2.779e-14 6.253e-13
9 hsa04650_Natural_killer_cell_mediated_cytotoxicity 12 136 1.082e-13 2.165e-12
10 hsa04620_Toll.like_receptor_signaling_pathway 11 102 1.305e-13 2.349e-12
11 hsa04662_B_cell_receptor_signaling_pathway 10 75 2.013e-13 3.294e-12
12 hsa04664_Fc_epsilon_RI_signaling_pathway 10 79 3.457e-13 5.186e-12
13 hsa04722_Neurotrophin_signaling_pathway 11 127 1.513e-12 2.096e-11
14 hsa04973_Carbohydrate_digestion_and_absorption 8 44 4.236e-12 5.446e-11
15 hsa04150_mTOR_signaling_pathway 8 52 1.756e-11 2.107e-10
16 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 1.902e-10 2.139e-09
17 hsa04510_Focal_adhesion 11 200 2.127e-10 2.252e-09
18 hsa04370_VEGF_signaling_pathway 8 76 4.096e-10 4.096e-09
19 hsa04914_Progesterone.mediated_oocyte_maturation 8 87 1.228e-09 1.164e-08
20 hsa04640_Hematopoietic_cell_lineage 8 88 1.347e-09 1.212e-08
21 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 2.495e-09 2.138e-08
22 hsa04920_Adipocytokine_signaling_pathway 7 68 6.324e-09 5.174e-08
23 hsa04670_Leukocyte_transendothelial_migration 8 117 1.311e-08 1.026e-07
24 hsa04070_Phosphatidylinositol_signaling_system 7 78 1.673e-08 1.255e-07
25 hsa04014_Ras_signaling_pathway 10 236 1.833e-08 1.32e-07
26 hsa04810_Regulation_of_actin_cytoskeleton 9 214 1.059e-07 7.331e-07
27 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.0001762 0.001175
28 hsa04672_Intestinal_immune_network_for_IgA_production 3 49 0.0008244 0.0053
29 hsa04144_Endocytosis 5 203 0.0009952 0.006177
30 hsa00562_Inositol_phosphate_metabolism 3 57 0.001281 0.007689
31 hsa04110_Cell_cycle 4 128 0.00137 0.007953
32 hsa04310_Wnt_signaling_pathway 4 151 0.002505 0.01409
33 hsa04320_Dorso.ventral_axis_formation 2 25 0.003936 0.02125
34 hsa04350_TGF.beta_signaling_pathway 3 85 0.004013 0.02125
35 hsa04330_Notch_signaling_pathway 2 47 0.01345 0.06918
36 hsa04010_MAPK_signaling_pathway 4 268 0.01824 0.09121
37 hsa04720_Long.term_potentiation 2 70 0.02844 0.1383
38 hsa04520_Adherens_junction 2 73 0.03072 0.1455
39 hsa04540_Gap_junction 2 90 0.04496 0.2075
40 hsa04912_GnRH_signaling_pathway 2 101 0.05523 0.2425
41 hsa04916_Melanogenesis 2 101 0.05523 0.2425
42 hsa04390_Hippo_signaling_pathway 2 154 0.1138 0.4875

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 25 AKT3 Sponge network 1.057 0.31716 0.457 0.53933 0.542
2

CECR7

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-128-3p;hsa-miR-1296-5p;hsa-miR-148a-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-26b-5p;hsa-miR-29b-1-5p;hsa-miR-30c-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-7-1-3p;hsa-miR-760 23 LIFR Sponge network 0.551 0.56177 0.297 0.5365 0.531
3

CECR7

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-93-5p 20 AKT3 Sponge network 0.551 0.56177 0.457 0.53933 0.508
4

EMX2OS

hsa-let-7g-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-29a-5p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-624-5p;hsa-miR-7-1-3p 10 GHR Sponge network 1.057 0.31716 0.571 0.24502 0.46
5

EMX2OS

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-128-3p;hsa-miR-144-3p;hsa-miR-148a-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29b-1-5p;hsa-miR-30c-1-3p;hsa-miR-30d-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-374a-3p;hsa-miR-421;hsa-miR-577;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-7-1-3p;hsa-miR-760;hsa-miR-940 27 LIFR Sponge network 1.057 0.31716 0.297 0.5365 0.441
6

MEG3

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-93-5p 12 AKT3 Sponge network 0.433 0.33816 0.457 0.53933 0.405
7

CECR7

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-let-7f-2-3p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-148a-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-190a-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-24-2-5p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-361-5p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-532-5p;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-592;hsa-miR-629-3p;hsa-miR-7-1-3p 50 IL6ST Sponge network 0.551 0.56177 -0.113 0.90216 0.399
8

CECR7

hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-148a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-20a-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-331-3p;hsa-miR-335-5p;hsa-miR-33a-5p;hsa-miR-454-3p;hsa-miR-590-5p;hsa-miR-93-5p 20 IL6R Sponge network 0.551 0.56177 0.14 0.82814 0.386
9

CECR7

hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-590-5p 11 PIK3CA Sponge network 0.551 0.56177 0.023 0.97942 0.368
10 MIAT hsa-miR-135b-5p;hsa-miR-182-5p;hsa-miR-192-5p;hsa-miR-19b-3p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-26b-5p;hsa-miR-301a-3p;hsa-miR-335-5p;hsa-miR-362-5p;hsa-miR-374b-3p;hsa-miR-454-3p;hsa-miR-491-3p 13 IL6ST Sponge network -0.118 0.86338 -0.113 0.90216 0.366
11

CECR7

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 13 LEPR Sponge network 0.551 0.56177 0.642 0.2849 0.356
12

EMX2OS

hsa-miR-130b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-30d-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 14 TPO Sponge network 1.057 0.31716 -0.238 0.80147 0.352
13

EMX2OS

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-148a-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-190a-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-24-2-5p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-362-3p;hsa-miR-374b-3p;hsa-miR-421;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-505-3p;hsa-miR-576-5p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-592;hsa-miR-629-3p;hsa-miR-7-1-3p;hsa-miR-93-3p 48 IL6ST Sponge network 1.057 0.31716 -0.113 0.90216 0.352
14

EMX2OS

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-7-1-3p;hsa-miR-877-5p 15 LEPR Sponge network 1.057 0.31716 0.642 0.2849 0.337
15

CECR7

hsa-miR-130b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-7-1-3p 11 TPO Sponge network 0.551 0.56177 -0.238 0.80147 0.323
16

CECR7

hsa-let-7g-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-29a-5p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-7-1-3p 10 GHR Sponge network 0.551 0.56177 0.571 0.24502 0.303
17

ZNF883

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-33a-3p 10 AKT3 Sponge network 0.913 0.16772 0.457 0.53933 0.3
18

MEG3

hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-26b-5p;hsa-miR-29b-1-5p;hsa-miR-30c-1-3p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-577;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-96-5p 13 LIFR Sponge network 0.433 0.33816 0.297 0.5365 0.276
19

EMX2OS

hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-576-5p;hsa-miR-582-3p;hsa-miR-590-3p 13 PIK3CA Sponge network 1.057 0.31716 0.023 0.97942 0.254

Quest ID: aff5dcca785520b3bf59eab126c2707e