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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-454-3p ACSL1 1.4 0.00366 -0.26 0.66804 MirTarget -0.21 0.00407 NA
2 hsa-miR-454-3p ACSL4 1.4 0.00366 -0.89 0.13062 MirTarget; miRNATAP -0.14 0.04315 NA
3 hsa-miR-454-3p ACVR1 1.4 0.00366 -0.76 0.04389 MirTarget; miRNATAP -0.12 0.00599 NA
4 hsa-miR-454-3p AKAP11 1.4 0.00366 -0.61 0.12508 miRNATAP -0.12 0.00898 NA
5 hsa-miR-454-3p AMPD3 1.4 0.00366 1.34 0.01947 MirTarget; miRNATAP -0.28 3.0E-5 NA
6 hsa-miR-454-3p ANKRD12 1.4 0.00366 -0.49 0.18892 MirTarget; miRNATAP -0.11 0.01667 NA
7 hsa-miR-106a-5p APCDD1 3.99 0 -2.17 0.00459 MirTarget -0.15 0.00407 NA
8 hsa-miR-130b-3p APCDD1 3.92 0 -2.17 0.00459 MirTarget -0.18 0.0162 NA
9 hsa-miR-20b-5p APCDD1 4.57 5.0E-5 -2.17 0.00459 MirTarget -0.1 0.00797 NA
10 hsa-miR-330-5p APCDD1 2.25 0.00028 -2.17 0.00459 miRanda -0.14 0.04065 NA
11 hsa-miR-93-5p APCDD1 2.66 0 -2.17 0.00459 MirTarget -0.23 0.01143 NA
12 hsa-miR-454-3p AR 1.4 0.00366 -4.57 0.00169 mirMAP; miRNATAP -0.47 0.00625 NA
13 hsa-miR-454-3p ARAP2 1.4 0.00366 1.71 0.00222 MirTarget -0.2 0.00207 NA
14 hsa-miR-454-3p ARHGAP21 1.4 0.00366 -0.14 0.76187 MirTarget; miRNATAP -0.14 0.01042 NA
15 hsa-miR-454-3p ARHGEF12 1.4 0.00366 -0.4 0.28538 MirTarget; miRNATAP -0.16 0.0003 NA
16 hsa-miR-454-3p ASPA 1.4 0.00366 -5.53 0 mirMAP -0.32 0.02559 NA
17 hsa-miR-454-3p ASXL2 1.4 0.00366 0.95 0.22717 MirTarget; miRNATAP -0.2 0.03105 NA
18 hsa-miR-454-3p ATP6V1B2 1.4 0.00366 0.23 0.47152 MirTarget; miRNATAP -0.1 0.00585 NA
19 hsa-miR-454-3p ATXN1 1.4 0.00366 -1.43 0.00387 miRNATAP -0.17 0.00303 NA
20 hsa-miR-454-3p BBX 1.4 0.00366 -0.18 0.63612 MirTarget; miRNATAP -0.1 0.02182 NA
21 hsa-miR-454-3p BCL9L 1.4 0.00366 -0.12 0.78985 mirMAP -0.14 0.00577 NA
22 hsa-miR-454-3p BRWD3 1.4 0.00366 2.22 0.00115 MirTarget; miRNATAP -0.2 0.01287 NA
23 hsa-miR-454-3p BTBD10 1.4 0.00366 0.43 0.25557 MirTarget -0.18 3.0E-5 NA
24 hsa-miR-454-3p BTG1 1.4 0.00366 -0.9 0.02841 miRNATAP -0.11 0.02771 NA
25 hsa-miR-454-3p C15orf52 1.4 0.00366 -1.2 0.18499 mirMAP -0.36 0.00077 NA
26 hsa-miR-454-3p C1S 1.4 0.00366 -2.07 0.01886 MirTarget -0.25 0.01612 NA
27 hsa-miR-454-3p CD109 1.4 0.00366 -0.13 0.90668 mirMAP -0.3 0.02391 NA
28 hsa-miR-454-3p CD69 1.4 0.00366 -0.72 0.42333 miRNATAP -0.25 0.01834 NA
29 hsa-miR-454-3p CDH11 1.4 0.00366 -2.72 0.00843 mirMAP -0.48 7.0E-5 NA
30 hsa-miR-454-3p CHD9 1.4 0.00366 -0.3 0.4758 miRNATAP -0.17 0.00054 NA
31 hsa-miR-454-3p CLIP1 1.4 0.00366 0.26 0.56626 MirTarget; miRNATAP -0.21 7.0E-5 NA
32 hsa-miR-454-3p CPEB2 1.4 0.00366 -0.48 0.40022 miRNATAP -0.16 0.01428 NA
33 hsa-miR-454-3p CPEB4 1.4 0.00366 -0.65 0.23946 miRNATAP -0.16 0.01341 NA
34 hsa-miR-454-3p CRISPLD1 1.4 0.00366 -3 0.03284 MirTarget -0.4 0.01665 NA
35 hsa-miR-454-3p CSF1 1.4 0.00366 -1.1 0.12732 MirTarget; miRNATAP -0.2 0.02018 NA
36 hsa-miR-454-3p CTSK 1.4 0.00366 -3.32 1.0E-5 MirTarget -0.47 0 NA
37 hsa-miR-454-3p CYLD 1.4 0.00366 -0.05 0.90145 miRNATAP -0.12 0.0045 25824771 MiR 454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression; Bioinformatics analysis further revealed cylindromatosis CYLD a putative tumor suppressor as a potential target of miR-454; Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region 3'-UTR of CYLD mRNA and repressed expression at both transcriptional and translational levels; In sum our data provide compelling evidence that miR-454 functions as an onco-miRNA playing a crucial role in the promoting cell proliferation in CRC and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression
38 hsa-miR-454-3p CYP4F3 1.4 0.00366 5.4 0.001 mirMAP -0.39 0.04343 NA
39 hsa-miR-454-3p DAAM1 1.4 0.00366 0.28 0.67526 MirTarget; miRNATAP -0.24 0.00186 NA
40 hsa-miR-454-3p DLC1 1.4 0.00366 -3.66 0 miRNATAP -0.3 0.00062 NA
41 hsa-miR-454-3p DNM3 1.4 0.00366 -2.57 0.00056 mirMAP -0.27 0.00193 NA
42 hsa-miR-454-3p DYRK2 1.4 0.00366 0.06 0.87911 mirMAP -0.11 0.02274 NA
43 hsa-miR-454-3p EEA1 1.4 0.00366 -0.24 0.59857 mirMAP -0.23 2.0E-5 NA
44 hsa-miR-454-3p ELK3 1.4 0.00366 -0.79 0.2934 MirTarget; miRNATAP -0.42 0 NA
45 hsa-miR-454-3p ENAH 1.4 0.00366 -0.27 0.60264 miRNATAP -0.13 0.03879 NA
46 hsa-miR-454-3p ENDOD1 1.4 0.00366 -1.15 0.01857 MirTarget -0.23 4.0E-5 NA
47 hsa-miR-454-3p ESR1 1.4 0.00366 -4.87 9.0E-5 miRNATAP -0.52 0.00045 NA
48 hsa-miR-454-3p EVI5 1.4 0.00366 -0.95 0.00393 mirMAP -0.1 0.00889 NA
49 hsa-miR-454-3p FAM155A 1.4 0.00366 -3.09 0.00443 MirTarget -0.36 0.00573 NA
50 hsa-miR-454-3p FAM179B 1.4 0.00366 -0.56 0.15244 miRNATAP -0.12 0.0124 NA
51 hsa-miR-454-3p FAM46B 1.4 0.00366 0.42 0.68311 MirTarget; miRNATAP -0.29 0.01569 NA
52 hsa-miR-454-3p FIBIN 1.4 0.00366 -3.85 0.00528 MirTarget -0.66 4.0E-5 NA
53 hsa-miR-454-3p FMN1 1.4 0.00366 1.87 0.076 mirMAP -0.29 0.02163 NA
54 hsa-miR-454-3p FOSL1 1.4 0.00366 2.1 0.0498 MirTarget -0.34 0.00737 NA
55 hsa-miR-454-3p FRMD6 1.4 0.00366 -1.61 0.08207 MirTarget -0.41 0.00018 NA
56 hsa-miR-454-3p FRZB 1.4 0.00366 -4.07 5.0E-5 MirTarget -0.25 0.0365 NA
57 hsa-miR-454-3p FZD6 1.4 0.00366 1.58 0.00919 MirTarget -0.15 0.04098 NA
58 hsa-miR-454-3p G0S2 1.4 0.00366 0.4 0.71817 MirTarget -0.33 0.01043 NA
59 hsa-miR-454-3p GADD45A 1.4 0.00366 -0.57 0.35686 MirTarget; miRNATAP -0.31 2.0E-5 NA
60 hsa-miR-454-3p GBP4 1.4 0.00366 0.55 0.60015 mirMAP -0.28 0.02105 NA
61 hsa-miR-454-3p GCLM 1.4 0.00366 1.75 0.00401 mirMAP -0.17 0.01881 NA
62 hsa-miR-454-3p GFOD1 1.4 0.00366 0.92 0.20897 mirMAP -0.19 0.02487 NA
63 hsa-miR-454-3p GJA1 1.4 0.00366 -1.39 0.17815 MirTarget; miRNATAP -0.29 0.01745 NA
64 hsa-miR-454-3p GPR157 1.4 0.00366 2.04 0.0467 mirMAP -0.28 0.02172 NA
65 hsa-miR-454-3p GPRC5A 1.4 0.00366 1.52 0.16803 mirMAP -0.28 0.03169 NA
66 hsa-miR-454-3p HECW2 1.4 0.00366 -0.59 0.4122 MirTarget -0.3 0.00041 NA
67 hsa-miR-454-3p HEG1 1.4 0.00366 -1.11 0.15703 miRNATAP -0.38 3.0E-5 NA
68 hsa-miR-454-3p HERC3 1.4 0.00366 -0.31 0.56561 MirTarget -0.17 0.00587 NA
69 hsa-miR-454-3p HES2 1.4 0.00366 6.53 1.0E-5 mirMAP -0.46 0.00885 NA
70 hsa-miR-454-3p HIPK3 1.4 0.00366 -0.3 0.74415 MirTarget -0.27 0.01549 NA
71 hsa-miR-454-3p HIVEP2 1.4 0.00366 0.14 0.72176 miRNATAP -0.14 0.00237 NA
72 hsa-miR-454-3p HRH1 1.4 0.00366 -0.68 0.33264 mirMAP -0.25 0.00253 NA
73 hsa-miR-454-3p IGF1 1.4 0.00366 -4.48 0.00149 MirTarget -0.4 0.01817 NA
74 hsa-miR-454-3p IL1RAP 1.4 0.00366 1.81 0.02672 MirTarget -0.21 0.02802 NA
75 hsa-miR-454-3p ITGA2 1.4 0.00366 2.49 0.01604 mirMAP -0.27 0.02766 NA
76 hsa-miR-454-3p ITGA8 1.4 0.00366 -4.42 0.00157 mirMAP -0.58 0.00047 NA
77 hsa-miR-454-3p ITPR1 1.4 0.00366 -3.7 0 MirTarget; miRNATAP -0.37 0 NA
78 hsa-miR-454-3p JAM2 1.4 0.00366 -5.56 0 miRNATAP -0.38 0.00044 NA
79 hsa-miR-454-3p KCTD10 1.4 0.00366 -1.32 0 MirTarget -0.13 4.0E-5 NA
80 hsa-miR-454-3p KIAA1462 1.4 0.00366 -4.22 0 MirTarget -0.23 0.00673 NA
81 hsa-miR-454-3p KLF3 1.4 0.00366 0.06 0.86707 miRNATAP -0.13 0.00241 NA
82 hsa-miR-454-3p KLF7 1.4 0.00366 0.14 0.86538 MirTarget; miRNATAP -0.23 0.02034 NA
83 hsa-miR-454-3p KLHL20 1.4 0.00366 -0.29 0.43362 MirTarget; miRNATAP -0.16 0.00028 NA
84 hsa-miR-454-3p LDLR 1.4 0.00366 0.07 0.90897 miRNATAP -0.18 0.01661 NA
85 hsa-miR-454-3p LIPA 1.4 0.00366 -0.18 0.71748 MirTarget -0.12 0.04269 NA
86 hsa-miR-454-3p LNPEP 1.4 0.00366 1.08 0.04117 MirTarget; miRNATAP -0.13 0.03362 NA
87 hsa-miR-454-3p LPP 1.4 0.00366 -1.15 0.02938 mirMAP -0.19 0.00183 NA
88 hsa-miR-454-3p LRCH2 1.4 0.00366 -5.17 0 MirTarget; miRNATAP -0.44 0.00017 NA
89 hsa-miR-454-3p MAFB 1.4 0.00366 0.68 0.42819 miRNATAP -0.26 0.00981 NA
90 hsa-miR-454-3p MAP4 1.4 0.00366 -0.73 0.032 MirTarget -0.1 0.01022 NA
91 hsa-miR-454-3p MAPK10 1.4 0.00366 -4.03 0.00046 miRNATAP -0.57 2.0E-5 NA
92 hsa-miR-454-3p MBNL3 1.4 0.00366 1.26 0.12966 MirTarget; mirMAP; miRNATAP -0.21 0.02942 NA
93 hsa-miR-454-3p MCC 1.4 0.00366 -0.68 0.46777 MirTarget -0.32 0.00382 NA
94 hsa-miR-454-3p MDFIC 1.4 0.00366 -1.36 0.0449 MirTarget; miRNATAP -0.2 0.01345 NA
95 hsa-miR-454-3p MEOX2 1.4 0.00366 -6.19 0 MirTarget; miRNATAP -0.34 0.01532 NA
96 hsa-miR-454-3p MID1IP1 1.4 0.00366 0.66 0.10505 miRNATAP -0.12 0.01561 NA
97 hsa-miR-454-3p MMP16 1.4 0.00366 -2.72 0.00811 mirMAP -0.32 0.00815 NA
98 hsa-miR-454-3p MPPED2 1.4 0.00366 -2.45 0.15823 MirTarget -0.6 0.00333 NA
99 hsa-miR-454-3p MUC20 1.4 0.00366 1.73 0.20488 mirMAP -0.34 0.03626 NA
100 hsa-miR-454-3p NAP1L3 1.4 0.00366 -5.22 0 MirTarget -0.5 1.0E-5 NA
101 hsa-miR-454-3p NAV1 1.4 0.00366 0.37 0.59295 miRNATAP -0.31 0.00012 NA
102 hsa-miR-454-3p NFIA 1.4 0.00366 -0.82 0.18121 miRNATAP -0.22 0.00242 NA
103 hsa-miR-454-3p NFIC 1.4 0.00366 -0.58 0.41726 miRNATAP -0.17 0.04248 NA
104 hsa-miR-454-3p NHLH2 1.4 0.00366 2.73 0.13264 MirTarget; miRNATAP -0.55 0.01024 NA
105 hsa-miR-454-3p NOX4 1.4 0.00366 -2.45 0.00259 MirTarget -0.25 0.00813 NA
106 hsa-miR-454-3p NPAT 1.4 0.00366 0.09 0.81886 MirTarget; miRNATAP -0.12 0.00874 NA
107 hsa-miR-454-3p PCDHB4 1.4 0.00366 -4.44 0 MirTarget -0.41 0.00019 NA
108 hsa-miR-454-3p PDCD1LG2 1.4 0.00366 -0.81 0.39863 MirTarget -0.35 0.00234 NA
109 hsa-miR-454-3p PDGFRA 1.4 0.00366 -4.32 1.0E-5 MirTarget; miRNATAP -0.46 8.0E-5 NA
110 hsa-miR-454-3p PGM2L1 1.4 0.00366 -1.68 0.03208 MirTarget; miRNATAP -0.2 0.02728 NA
111 hsa-miR-454-3p PGR 1.4 0.00366 -7.62 0 mirMAP -0.66 0.00018 NA
112 hsa-miR-454-3p PLCB1 1.4 0.00366 -1.81 0.07239 miRNATAP -0.3 0.01148 NA
113 hsa-miR-454-3p PMEPA1 1.4 0.00366 -0.44 0.56222 MirTarget; miRNATAP -0.22 0.0153 NA
114 hsa-miR-454-3p PPP1R12B 1.4 0.00366 -4.65 0 mirMAP -0.37 1.0E-5 NA
115 hsa-miR-454-3p PRKG1 1.4 0.00366 -4.14 0.00035 miRNATAP -0.54 9.0E-5 NA
116 hsa-miR-454-3p PSD 1.4 0.00366 -5.74 0 miRNATAP -0.27 0.00711 NA
117 hsa-miR-454-3p PTGFRN 1.4 0.00366 0.01 0.98805 miRNATAP -0.13 0.01288 NA
118 hsa-miR-454-3p PXK 1.4 0.00366 -1.19 0.05304 MirTarget -0.17 0.02128 NA
119 hsa-miR-454-3p RALGPS2 1.4 0.00366 1.31 0.01845 MirTarget -0.2 0.00201 NA
120 hsa-miR-454-3p RAP2C 1.4 0.00366 -0.96 0.01088 MirTarget; miRNATAP -0.18 3.0E-5 NA
121 hsa-miR-454-3p RAPGEF4 1.4 0.00366 -2.71 0.0001 MirTarget; miRNATAP -0.18 0.03366 NA
122 hsa-miR-454-3p RARB 1.4 0.00366 -1.23 0.24963 miRNATAP -0.51 5.0E-5 NA
123 hsa-miR-454-3p RASL12 1.4 0.00366 -5.24 0 MirTarget -0.31 0.00122 NA
124 hsa-miR-454-3p RASSF6 1.4 0.00366 4.23 0.00014 mirMAP -0.27 0.03868 NA
125 hsa-miR-454-3p RC3H2 1.4 0.00366 0.73 0.09436 mirMAP -0.1 0.0489 NA
126 hsa-miR-454-3p RNF11 1.4 0.00366 -0.85 0.01247 miRNATAP -0.14 0.00051 NA
127 hsa-miR-454-3p ROBO1 1.4 0.00366 0.25 0.74813 miRNATAP -0.25 0.00697 NA
128 hsa-miR-454-3p ROBO2 1.4 0.00366 -1.5 0.3479 miRNATAP -0.5 0.00798 NA
129 hsa-miR-454-3p RUNX1T1 1.4 0.00366 -4.61 4.0E-5 miRNATAP -0.54 5.0E-5 NA
130 hsa-miR-454-3p RUNX2 1.4 0.00366 0.93 0.19285 miRNATAP -0.3 0.00038 NA
131 hsa-miR-454-3p S1PR1 1.4 0.00366 -4.01 0 MirTarget; miRNATAP -0.28 0.00027 NA
132 hsa-miR-454-3p SAMHD1 1.4 0.00366 1.22 0.08415 mirMAP -0.17 0.04153 NA
133 hsa-miR-454-3p SASH1 1.4 0.00366 -1.01 0.06247 MirTarget; miRNATAP -0.15 0.01615 NA
134 hsa-miR-454-3p SBF2 1.4 0.00366 -0.78 0.06145 MirTarget -0.14 0.00328 NA
135 hsa-miR-454-3p SCN3A 1.4 0.00366 -3.02 0.0067 MirTarget -0.3 0.0227 NA
136 hsa-miR-454-3p SESN3 1.4 0.00366 -0.38 0.69604 mirMAP -0.3 0.00906 NA
137 hsa-miR-454-3p SETD7 1.4 0.00366 -1.43 0.00158 miRNATAP -0.11 0.0386 NA
138 hsa-miR-454-3p SH3D19 1.4 0.00366 -1.17 0.00804 MirTarget; miRNATAP -0.22 2.0E-5 NA
139 hsa-miR-454-3p SHROOM4 1.4 0.00366 -2.05 0.01488 mirMAP -0.29 0.00335 NA
140 hsa-miR-454-3p SLC24A3 1.4 0.00366 -4.25 0.00045 MirTarget; miRNATAP -0.46 0.00125 NA
141 hsa-miR-454-3p SLC35D1 1.4 0.00366 0.16 0.71932 MirTarget -0.17 0.00137 NA
142 hsa-miR-454-3p SLC8A1 1.4 0.00366 -4.53 0 MirTarget -0.35 0.00027 NA
143 hsa-miR-454-3p SLIT3 1.4 0.00366 -4.87 1.0E-5 mirMAP -0.38 0.00345 NA
144 hsa-miR-454-3p SLMAP 1.4 0.00366 -1.88 0 MirTarget -0.19 1.0E-5 NA
145 hsa-miR-454-3p SMOC2 1.4 0.00366 -6.42 0 miRNATAP -0.33 0.00948 NA
146 hsa-miR-454-3p SNX30 1.4 0.00366 0.08 0.84819 mirMAP -0.13 0.01105 NA
147 hsa-miR-454-3p SNX31 1.4 0.00366 0.34 0.85342 MirTarget -0.9 3.0E-5 NA
148 hsa-miR-454-3p SOS2 1.4 0.00366 -0.27 0.49693 miRNATAP -0.1 0.02684 NA
149 hsa-miR-454-3p SPEN 1.4 0.00366 0.27 0.46575 MirTarget; miRNATAP -0.1 0.01681 NA
150 hsa-miR-454-3p SPOCK1 1.4 0.00366 -3.14 0.0073 MirTarget -0.45 0.00125 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 40 1805 1.274e-07 0.0005928
2 POSITIVE REGULATION OF MOLECULAR FUNCTION 38 1791 8.377e-07 0.001008
3 ORGAN MORPHOGENESIS 24 841 8.667e-07 0.001008
4 NEGATIVE REGULATION OF CELL PROLIFERATION 21 643 5.232e-07 0.001008
5 SKELETAL SYSTEM DEVELOPMENT 17 455 1.113e-06 0.001035
6 EMBRYONIC ORGAN MORPHOGENESIS 13 279 1.978e-06 0.001534
7 DEVELOPMENTAL GROWTH 14 333 2.647e-06 0.00176
8 TISSUE DEVELOPMENT 33 1518 3.033e-06 0.001764
9 TUBE DEVELOPMENT 18 552 3.649e-06 0.001886
10 EMBRYO DEVELOPMENT 23 894 8.325e-06 0.002421
11 POSITIVE REGULATION OF CATALYTIC ACTIVITY 32 1518 8.288e-06 0.002421
12 GROWTH 15 410 6.292e-06 0.002421
13 CARDIAC MUSCLE TISSUE DEVELOPMENT 9 140 6.041e-06 0.002421
14 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 7.314e-06 0.002421
15 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 10 184 8.168e-06 0.002421
16 CENTRAL NERVOUS SYSTEM DEVELOPMENT 23 872 5.55e-06 0.002421
17 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 34 1672 8.906e-06 0.002438
18 MUSCLE TISSUE DEVELOPMENT 12 275 9.629e-06 0.002489
19 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 17 554 1.514e-05 0.003457
20 BONE DEVELOPMENT 9 156 1.45e-05 0.003457
21 REGULATION OF CELL DIFFERENTIATION 31 1492 1.56e-05 0.003457
22 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 24 1004 1.762e-05 0.003727
23 POSITIVE REGULATION OF GENE EXPRESSION 34 1733 1.89e-05 0.003824
24 EPITHELIUM DEVELOPMENT 23 945 2.018e-05 0.003913
25 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 24 1021 2.314e-05 0.004306
26 EMBRYONIC ORGAN DEVELOPMENT 14 406 2.494e-05 0.004463
27 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 24 1036 2.925e-05 0.004775
28 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 1036 2.925e-05 0.004775
29 CARDIOCYTE DIFFERENTIATION 7 96 2.976e-05 0.004775
30 HEAD DEVELOPMENT 19 709 3.09e-05 0.004793
31 NEUROGENESIS 29 1402 3.312e-05 0.004972
32 TISSUE MORPHOGENESIS 16 533 3.546e-05 0.005156
33 ORGAN GROWTH 6 68 3.811e-05 0.005373
34 EMBRYONIC MORPHOGENESIS 16 539 4.053e-05 0.005547
35 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 28 1360 5.001e-05 0.006123
36 TUBE MORPHOGENESIS 12 323 4.701e-05 0.006123
37 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 25 1142 4.982e-05 0.006123
38 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 7 104 4.986e-05 0.006123
39 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 11 278 5.562e-05 0.00647
40 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 23 1008 5.483e-05 0.00647
41 CARDIAC MUSCLE CELL DIFFERENTIATION 6 74 6.163e-05 0.006994
42 CARTILAGE DEVELOPMENT 8 147 6.614e-05 0.007328
43 REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 1618 7.304e-05 0.007903
44 CONNECTIVE TISSUE DEVELOPMENT 9 194 8.02e-05 0.008481
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 12 226 1.279e-06 0.001188
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 13 315 7.431e-06 0.003452
3 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 13 328 1.145e-05 0.003545
4 REGULATORY REGION NUCLEIC ACID BINDING 21 818 2.186e-05 0.004061
5 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 18 629 2.142e-05 0.004061
6 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 26 1199 4.068e-05 0.005504
7 CORE PROMOTER PROXIMAL REGION DNA BINDING 13 371 4.147e-05 0.005504
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 8 132 3.073e-05 0.001598
2 MAPK_signaling_pathway_hsa04010 11 295 9.449e-05 0.002457
3 Gap_junction_hsa04540 6 88 0.0001621 0.00281
4 Endocytosis_hsa04144 9 244 0.000444 0.005772
5 Hippo_signaling_pathway_hsa04390 7 154 0.0005672 0.005899
6 Oocyte_meiosis_hsa04114 6 124 0.001017 0.008818
7 Wnt_signaling_pathway_hsa04310 6 146 0.002341 0.0144
8 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.002347 0.0144
9 Focal_adhesion_hsa04510 7 199 0.002496 0.0144
10 mTOR_signaling_pathway_hsa04150 6 151 0.002769 0.0144
11 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.003192 0.01509
12 p53_signaling_pathway_hsa04115 4 68 0.00357 0.01547
13 Ferroptosis_hsa04216 3 40 0.005895 0.02358
14 TGF_beta_signaling_pathway_hsa04350 4 84 0.007553 0.02805
15 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.01136 0.03939
16 Cellular_senescence_hsa04218 5 160 0.01632 0.05305
17 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.01755 0.05367
18 Calcium_signaling_pathway_hsa04020 5 182 0.02672 0.07718
19 Apoptosis_hsa04210 4 138 0.03879 0.0982
20 Cytokine_cytokine_receptor_interaction_hsa04060 6 270 0.03909 0.0982
21 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.03966 0.0982
22 Rap1_signaling_pathway_hsa04015 5 206 0.04203 0.09935
23 Phagosome_hsa04145 4 152 0.05203 0.1176
24 Ras_signaling_pathway_hsa04014 5 232 0.0636 0.1378
25 Sphingolipid_signaling_pathway_hsa04071 3 118 0.09531 0.1983
26 Lysosome_hsa04142 3 123 0.1046 0.2062
27 PI3K_Akt_signaling_pathway_hsa04151 6 352 0.1071 0.2062
28 Apelin_signaling_pathway_hsa04371 3 137 0.1325 0.2461
29 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.1495 0.268
30 ECM_receptor_interaction_hsa04512 2 82 0.1743 0.2979
31 Peroxisome_hsa04146 2 83 0.1776 0.2979
32 ErbB_signaling_pathway_hsa04012 2 85 0.1842 0.2993
33 Tight_junction_hsa04530 3 170 0.2064 0.3252
34 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.2312 0.3536
35 TNF_signaling_pathway_hsa04668 2 108 0.2619 0.38
36 Cell_cycle_hsa04110 2 124 0.3163 0.4445
37 Autophagy_animal_hsa04140 2 128 0.3298 0.4512
38 Jak_STAT_signaling_pathway_hsa04630 2 162 0.4404 0.5734
39 Necroptosis_hsa04217 2 164 0.4466 0.5734
40 cAMP_signaling_pathway_hsa04024 2 198 0.5459 0.6601
41 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.7279 0.8228

Quest ID: b4ab9b88f5f7760000787fcb946ab300