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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-326 CIRBP 0.03 0.83944 -0.01 0.90896 miRanda -0.14 1.0E-5 NA
2 hsa-miR-330-5p CIRBP 1.45 0 -0.01 0.90896 miRanda -0.15 0.00013 NA
3 hsa-miR-484 CIRBP 0.57 0 -0.01 0.90896 mirMAP; miRNATAP -0.22 0 NA
4 hsa-miR-590-3p CIRBP 1.14 0 -0.01 0.90896 miRanda -0.12 0.00096 NA
5 hsa-miR-590-5p CIRBP 0.71 0 -0.01 0.90896 miRanda -0.16 0.00024 NA
6 hsa-miR-616-5p CIRBP 0.91 0 -0.01 0.90896 mirMAP -0.12 5.0E-5 NA
7 hsa-miR-629-3p CIRBP 1.09 0 -0.01 0.90896 mirMAP -0.14 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 MRNA METABOLIC PROCESS 44 611 2.209e-29 1.028e-25
2 RNA PROCESSING 48 835 9.731e-28 2.264e-24
3 MRNA PROCESSING 34 432 6.947e-24 1.077e-20
4 RNA SPLICING 30 367 1.388e-21 1.614e-18
5 RNA SPLICING VIA TRANSESTERIFICATION REACTIONS 25 267 1.613e-19 1.501e-16
6 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 24 440 1.79e-13 1.388e-10
7 MITOTIC CELL CYCLE 28 766 2.394e-11 1.392e-08
8 CELL CYCLE 37 1316 2.145e-11 1.392e-08
9 CELL CYCLE PHASE TRANSITION 17 255 3.334e-11 1.622e-08
10 PROTEIN IMPORT 14 155 3.485e-11 1.622e-08
11 NUCLEAR IMPORT 13 129 4.495e-11 1.902e-08
12 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 21 448 1.109e-10 3.731e-08
13 CELL CYCLE G1 S PHASE TRANSITION 12 111 1.122e-10 3.731e-08
14 G1 S TRANSITION OF MITOTIC CELL CYCLE 12 111 1.122e-10 3.731e-08
15 NLS BEARING PROTEIN IMPORT INTO NUCLEUS 7 22 3.229e-10 1.002e-07
16 PROTEIN LOCALIZATION TO NUCLEUS 13 156 4.92e-10 1.431e-07
17 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 12 129 6.564e-10 1.797e-07
18 PROTEIN LOCALIZATION TO ORGANELLE 22 556 9.526e-10 2.463e-07
19 REGULATION OF CHROMOSOME ORGANIZATION 16 278 1.125e-09 2.755e-07
20 REGULATION OF RNA STABILITY 12 139 1.559e-09 3.627e-07
21 REGULATION OF CELL CYCLE 28 949 3.081e-09 6.796e-07
22 CELL CYCLE PROCESS 30 1081 3.213e-09 6.796e-07
23 NUCLEAR TRANSPORT 17 355 5.378e-09 1.088e-06
24 MACROMOLECULAR COMPLEX ASSEMBLY 34 1398 6.952e-09 1.348e-06
25 RNA 3 END PROCESSING 10 98 7.411e-09 1.379e-06
26 POSITIVE REGULATION OF GENE EXPRESSION 38 1733 1.262e-08 2.174e-06
27 DNA METABOLIC PROCESS 24 758 1.244e-08 2.174e-06
28 REGULATION OF DNA METABOLIC PROCESS 16 340 1.983e-08 3.295e-06
29 CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY 23 727 2.625e-08 4.211e-06
30 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 13 218 2.867e-08 4.447e-06
31 REGULATION OF PROTEIN STABILITY 13 221 3.371e-08 4.901e-06
32 MACROMOLECULE CATABOLIC PROCESS 26 926 3.31e-08 4.901e-06
33 RIBOSOME BIOGENESIS 15 308 3.579e-08 5.046e-06
34 PROTEIN FOLDING 13 224 3.952e-08 5.409e-06
35 CHAPERONE MEDIATED PROTEIN COMPLEX ASSEMBLY 5 13 4.128e-08 5.488e-06
36 REGULATION OF MRNA METABOLIC PROCESS 10 118 4.486e-08 5.586e-06
37 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 16 360 4.39e-08 5.586e-06
38 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 16 361 4.562e-08 5.586e-06
39 REGULATION OF PROTEIN LOCALIZATION TO CHROMOSOME TELOMERIC REGION 5 14 6.379e-08 7.611e-06
40 CELL CYCLE CHECKPOINT 12 194 6.676e-08 7.765e-06
41 REGULATION OF TELOMERE MAINTENANCE 8 67 7.104e-08 8.063e-06
42 NCRNA METABOLIC PROCESS 19 533 7.565e-08 8.381e-06
43 MULTI ORGANISM TRANSPORT 8 68 7.996e-08 8.456e-06
44 MULTI ORGANISM LOCALIZATION 8 68 7.996e-08 8.456e-06
45 NEGATIVE REGULATION OF CELL CYCLE 17 433 9.803e-08 1.014e-05
46 INTERSPECIES INTERACTION BETWEEN ORGANISMS 21 662 1.072e-07 1.062e-05
47 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 21 662 1.072e-07 1.062e-05
48 MRNA 3 END PROCESSING 8 72 1.26e-07 1.221e-05
49 REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 7 50 1.562e-07 1.483e-05
50 RRNA METABOLIC PROCESS 13 255 1.792e-07 1.668e-05
51 CELL CYCLE G2 M PHASE TRANSITION 10 138 1.979e-07 1.806e-05
52 MITOTIC CELL CYCLE CHECKPOINT 10 139 2.118e-07 1.895e-05
53 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 15 354 2.19e-07 1.923e-05
54 PROTEIN TARGETING 16 406 2.266e-07 1.952e-05
55 CELL DIVISION 17 460 2.313e-07 1.957e-05
56 MITOTIC NUCLEAR DIVISION 15 361 2.814e-07 2.338e-05
57 RNA LOCALIZATION 11 185 3.564e-07 2.909e-05
58 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 21 720 4.291e-07 3.443e-05
59 REGULATION OF CHROMOSOME SEGREGATION 8 85 4.63e-07 3.652e-05
60 REGULATION OF CELLULAR PROTEIN LOCALIZATION 18 552 6.269e-07 4.862e-05
61 NCRNA PROCESSING 15 386 6.575e-07 4.943e-05
62 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 121 6.586e-07 4.943e-05
63 RIBONUCLEOPROTEIN COMPLEX SUBUNIT ORGANIZATION 11 199 7.369e-07 5.422e-05
64 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 26 1087 7.457e-07 5.422e-05
65 REGULATION OF DNA REPLICATION 10 161 8.271e-07 5.921e-05
66 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 35 1805 1.035e-06 7.3e-05
67 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 12 254 1.21e-06 8.164e-05
68 NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION 8 96 1.183e-06 8.164e-05
69 REGULATION OF SISTER CHROMATID SEGREGATION 7 67 1.211e-06 8.164e-05
70 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO CHROMOSOME 4 11 1.342e-06 8.921e-05
71 POSITIVE REGULATION OF MRNA METABOLIC PROCESS 6 45 1.673e-06 0.0001097
72 POSITIVE REGULATION OF PROTEIN IMPORT 8 104 2.174e-06 0.0001405
73 CHROMOSOME ORGANIZATION 24 1009 2.311e-06 0.0001473
74 REGULATION OF CELL CYCLE PHASE TRANSITION 13 321 2.401e-06 0.000151
75 REGULATION OF PROTEIN IMPORT 10 183 2.645e-06 0.0001635
76 RNA CATABOLIC PROCESS 11 227 2.671e-06 0.0001635
77 MODULATION BY SYMBIONT OF HOST CELLULAR PROCESS 5 28 2.856e-06 0.0001666
78 REGULATION OF MRNA 3 END PROCESSING 5 28 2.856e-06 0.0001666
79 REGULATION OF PROTEIN LOCALIZATION 23 950 2.865e-06 0.0001666
80 HISTONE MRNA METABOLIC PROCESS 5 28 2.856e-06 0.0001666
81 ORGANELLE FISSION 16 496 3.138e-06 0.0001775
82 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 9 146 3.167e-06 0.0001775
83 DNA INTEGRITY CHECKPOINT 9 146 3.167e-06 0.0001775
84 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 12 280 3.33e-06 0.0001844
85 RNA POLYADENYLATION 5 29 3.428e-06 0.0001876
86 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 9 150 3.956e-06 0.000214
87 RNA STABILIZATION 5 31 4.84e-06 0.0002589
88 REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 4 15 5.412e-06 0.0002829
89 POSITIVE REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 4 15 5.412e-06 0.0002829
90 NUCLEOBASE CONTAINING COMPOUND TRANSPORT 10 199 5.585e-06 0.0002856
91 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 10 199 5.585e-06 0.0002856
92 POSITIVE REGULATION OF MRNA PROCESSING 5 32 5.699e-06 0.0002882
93 POSITIVE REGULATION OF DNA REPLICATION 7 86 6.572e-06 0.0003288
94 POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 5 33 6.673e-06 0.0003303
95 CELLULAR CATABOLIC PROCESS 27 1322 8.727e-06 0.0004274
96 CELLULAR RESPONSE TO STRESS 30 1565 8.944e-06 0.0004335
97 POSITIVE REGULATION OF MRNA 3 END PROCESSING 4 17 9.317e-06 0.0004469
98 TERMINATION OF RNA POLYMERASE II TRANSCRIPTION 6 62 1.127e-05 0.0005349
99 MODULATION BY VIRUS OF HOST MORPHOLOGY OR PHYSIOLOGY 5 37 1.194e-05 0.000561
100 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 8 131 1.213e-05 0.0005642
101 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 10 220 1.346e-05 0.00062
102 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 7 97 1.458e-05 0.000665
103 X DE NOVO PROTEIN FOLDING 4 19 1.498e-05 0.0006768
104 NUCLEUS ORGANIZATION 8 136 1.594e-05 0.0007132
105 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 8 139 1.868e-05 0.0008277
106 DNA TEMPLATED TRANSCRIPTION TERMINATION 7 101 1.899e-05 0.0008337
107 CELLULAR MACROMOLECULE LOCALIZATION 25 1234 2.249e-05 0.0009782
108 INTRACELLULAR SIGNAL TRANSDUCTION 29 1572 2.648e-05 0.001141
109 PROTEIN PHOSPHORYLATION 21 944 2.854e-05 0.001218
110 REGULATION OF ORGANELLE ORGANIZATION 24 1178 3.058e-05 0.001285
111 REGULATION OF MITOTIC CELL CYCLE 14 468 3.065e-05 0.001285
112 MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY 5 45 3.174e-05 0.001319
113 POSITIVE REGULATION OF CELL CYCLE PROCESS 10 247 3.632e-05 0.001496
114 MEMBRANE DISASSEMBLY 5 47 3.934e-05 0.001578
115 POSITIVE REGULATION OF TELOMERE MAINTENANCE 5 47 3.934e-05 0.001578
116 NUCLEAR ENVELOPE DISASSEMBLY 5 47 3.934e-05 0.001578
117 PROTEIN COMPLEX SUBUNIT ORGANIZATION 28 1527 4.152e-05 0.001651
118 SPINDLE CHECKPOINT 4 25 4.706e-05 0.00184
119 POSITIVE REGULATION OF CHROMOSOME SEGREGATION 4 25 4.706e-05 0.00184
120 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 13 427 4.964e-05 0.001925
121 DNA GEOMETRIC CHANGE 6 81 5.236e-05 0.002013
122 REGULATION OF CELL CYCLE PROCESS 15 558 5.398e-05 0.002059
123 REGULATION OF NUCLEAR DIVISION 8 163 5.841e-05 0.002174
124 RNA PHOSPHODIESTER BOND HYDROLYSIS 7 120 5.773e-05 0.002174
125 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 8 163 5.841e-05 0.002174
126 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 84 6.427e-05 0.002374
127 NEGATIVE REGULATION OF CELL CYCLE PROCESS 9 214 6.7e-05 0.002455
128 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 4 28 7.474e-05 0.002696
129 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 9 217 7.456e-05 0.002696
130 REGULATION OF CELL DIVISION 10 272 8.146e-05 0.002908
131 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 12 387 8.188e-05 0.002908
132 REGULATION OF TRANSFERASE ACTIVITY 20 946 9.047e-05 0.00316
133 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 724 9.07e-05 0.00316
134 POSITIVE REGULATION OF CELL CYCLE 11 332 9.101e-05 0.00316
135 REGULATION OF LIGASE ACTIVITY 7 130 9.579e-05 0.003301
136 PROTEIN STABILIZATION 7 131 0.0001005 0.003439
137 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 10 282 0.0001097 0.003726
138 MRNA MODIFICATION 3 12 0.0001108 0.003735
139 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 5 59 0.0001187 0.003972
140 REGULATION OF DNA BIOSYNTHETIC PROCESS 6 94 0.0001204 0.004002
141 CELL PROLIFERATION 16 672 0.0001256 0.004145
142 CELLULAR PROTEIN COMPLEX ASSEMBLY 11 346 0.0001309 0.00429
143 PROTEIN COMPLEX BIOGENESIS 22 1132 0.0001341 0.004333
144 PROTEIN COMPLEX ASSEMBLY 22 1132 0.0001341 0.004333
145 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 6 96 0.0001353 0.004341
146 POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 13 0.0001431 0.004534
147 REGULATION OF RNA SPLICING 6 97 0.0001432 0.004534
148 DNA REPAIR 13 480 0.0001601 0.005032
149 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 616 0.0001613 0.005037
150 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 4 34 0.000163 0.005055
151 MITOTIC DNA INTEGRITY CHECKPOINT 6 100 0.0001693 0.005218
152 X DE NOVO POSTTRANSLATIONAL PROTEIN FOLDING 3 14 0.0001811 0.005544
153 RNA PHOSPHODIESTER BOND HYDROLYSIS EXONUCLEOLYTIC 4 35 0.0001828 0.00556
154 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 30 1848 0.000194 0.005863
155 ESTABLISHMENT OF LOCALIZATION IN CELL 28 1676 0.0002047 0.006107
156 TOXIN TRANSPORT 4 36 0.0002044 0.006107
157 REGULATION OF PROTEIN TARGETING 10 307 0.0002186 0.006478
158 INTRACELLULAR PROTEIN TRANSPORT 17 781 0.0002236 0.006585
159 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 26 1517 0.0002394 0.007005
160 MITOTIC SPINDLE ORGANIZATION 5 69 0.0002495 0.007256
161 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 258 0.0002741 0.00792
162 RESPONSE TO ENDOGENOUS STIMULUS 25 1450 0.0002923 0.008397
163 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 6 111 0.0002989 0.008532
164 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 13 514 0.0003105 0.008811
165 DNA REPLICATION 8 208 0.0003135 0.00884
166 CELLULAR COMPONENT DISASSEMBLY 13 515 0.0003164 0.008868
167 SEXUAL REPRODUCTION 16 730 0.000319 0.008888
168 G1 DNA DAMAGE CHECKPOINT 5 73 0.0003249 0.008997
169 REPRODUCTION 23 1297 0.0003528 0.009713
170 MULTI ORGANISM REPRODUCTIVE PROCESS 18 891 0.0003593 0.009833
NumGOOverlapSizeP ValueAdj. P Value
1 RNA BINDING 79 1598 3.065e-43 2.848e-40
2 POLY A RNA BINDING 67 1170 1.03e-39 4.785e-37
3 RIBONUCLEOTIDE BINDING 52 1860 5.428e-16 1.681e-13
4 ADENYL NUCLEOTIDE BINDING 45 1514 1.037e-14 2.408e-12
5 NUCLEAR LOCALIZATION SEQUENCE BINDING 8 21 3.045e-12 5.658e-10
6 SIGNAL SEQUENCE BINDING 8 39 8.13e-10 1.259e-07
7 MRNA BINDING 11 155 5.911e-08 7.844e-06
8 PURINE NTP DEPENDENT HELICASE ACTIVITY 9 98 1.076e-07 1.25e-05
9 CYCLIN BINDING 5 19 3.585e-07 3.028e-05
10 POLY PURINE TRACT BINDING 5 19 3.585e-07 3.028e-05
11 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 6 34 2.975e-07 3.028e-05
12 ENZYME BINDING 35 1737 4.214e-07 3.262e-05
13 HELICASE ACTIVITY 10 153 5.174e-07 3.697e-05
14 HEAT SHOCK PROTEIN BINDING 8 89 6.61e-07 4.386e-05
15 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 22 820 9.06e-07 5.611e-05
16 RNA HELICASE ACTIVITY 7 67 1.211e-06 7.03e-05
17 PROTEIN TRANSPORTER ACTIVITY 8 99 1.496e-06 8.174e-05
18 UNFOLDED PROTEIN BINDING 8 100 1.615e-06 8.333e-05
19 PROTEIN SERINE THREONINE KINASE ACTIVITY 14 445 1.76e-05 0.0008606
20 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 22 992 1.897e-05 0.0008812
21 SINGLE STRANDED RNA BINDING 6 69 2.096e-05 0.0009272
22 ATPASE ACTIVITY 13 427 4.964e-05 0.002096
23 ATPASE ACTIVITY COUPLED 11 313 5.378e-05 0.002172
24 UBIQUITIN LIKE PROTEIN LIGASE BINDING 10 264 6.356e-05 0.00246
25 POLY A BINDING 3 13 0.0001431 0.005319
26 EXORIBONUCLEASE ACTIVITY 4 34 0.000163 0.005823
27 PROTEIN KINASE ACTIVITY 15 640 0.0002434 0.008376
28 RNA POLYMERASE II CARBOXY TERMINAL DOMAIN KINASE ACTIVITY 3 16 0.0002753 0.009134
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOPROTEIN COMPLEX 37 721 1.382e-19 8.071e-17
2 SPLICEOSOMAL COMPLEX 18 172 3.563e-15 1.04e-12
3 NUCLEOLUS 33 848 5.125e-14 9.976e-12
4 NUCLEAR PORE 9 77 1.276e-08 1.864e-06
5 NUCLEAR ENVELOPE 17 416 5.515e-08 5.368e-06
6 CATALYTIC STEP 2 SPLICEOSOME 9 89 4.627e-08 5.368e-06
7 CYTOPLASMIC STRESS GRANULE 6 32 2.032e-07 1.483e-05
8 NUCLEAR BODY 15 349 1.825e-07 1.483e-05
9 CHROMOSOME 23 880 7.837e-07 5.085e-05
10 NUCLEAR SPECK 10 194 4.456e-06 0.0002603
11 CHROMOSOMAL REGION 12 330 1.749e-05 0.0009285
12 NUCLEOPLASM PART 18 708 1.977e-05 0.000962
13 RIBONUCLEOPROTEIN GRANULE 8 148 2.938e-05 0.00132
14 CHROMOSOME TELOMERIC REGION 8 162 5.593e-05 0.002333
15 CAJAL BODY 5 52 6.45e-05 0.002511
16 ENDOPLASMIC RETICULUM CHAPERONE COMPLEX 3 11 8.358e-05 0.003051
17 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 4 31 0.0001127 0.003871
18 SPINDLE 10 289 0.0001341 0.00435
19 MICROTUBULE CYTOSKELETON 21 1068 0.0001643 0.005051
20 ENVELOPE 21 1090 0.000217 0.006337
21 CATALYTIC COMPLEX 20 1038 0.0003093 0.008602
22 ENDOCYTIC VESICLE LUMEN 3 17 0.0003323 0.008821

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 10 124 7.203e-08 1.873e-06
2 Oocyte_meiosis_hsa04114 10 124 7.203e-08 1.873e-06
3 Cellular_senescence_hsa04218 10 160 7.812e-07 1.354e-05
4 FoxO_signaling_pathway_hsa04068 7 132 0.0001054 0.00137
5 p53_signaling_pathway_hsa04115 5 68 0.0002329 0.002423
6 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.008375 0.07258
7 VEGF_signaling_pathway_hsa04370 3 59 0.01238 0.09195
8 Apoptosis_hsa04210 4 138 0.02652 0.1724
9 Wnt_signaling_pathway_hsa04310 4 146 0.03171 0.1832
10 Gap_junction_hsa04540 3 88 0.03525 0.1833
11 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.04457 0.2107
12 Hedgehog_signaling_pathway_hsa04340 2 47 0.05621 0.2436
13 MAPK_signaling_pathway_hsa04010 5 295 0.09408 0.3763
14 Adherens_junction_hsa04520 2 72 0.1168 0.4337
15 TGF_beta_signaling_pathway_hsa04350 2 84 0.1498 0.4878
16 Necroptosis_hsa04217 3 164 0.1501 0.4878
17 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.1814 0.555
18 HIF_1_signaling_pathway_hsa04066 2 100 0.1962 0.5667
19 TNF_signaling_pathway_hsa04668 2 108 0.22 0.5719
20 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.2407 0.5961
21 Phagosome_hsa04145 2 152 0.352 0.7959
22 Tight_junction_hsa04530 2 170 0.4043 0.8591
23 Calcium_signaling_pathway_hsa04020 2 182 0.438 0.8759
24 Focal_adhesion_hsa04510 2 199 0.4839 0.9001
25 Ras_signaling_pathway_hsa04014 2 232 0.5661 0.9497

Quest ID: b4d24eba871df50ca01deb887d8a1d8b