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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-107 ACVR1 0.68 0 -0.46 0 miRanda -0.34 0 NA
2 hsa-let-7d-5p ACVR1C 0.41 1.0E-5 -5.2 0 MirTarget; miRNATAP -0.38 0.00022 NA
3 hsa-let-7e-5p ACVR1C 0.26 0.00191 -5.2 0 MirTarget; miRNATAP -0.39 0.00048 NA
4 hsa-miR-181a-5p ACVR1C 0.64 0 -5.2 0 miRNATAP -0.62 0 NA
5 hsa-miR-181b-5p ACVR1C 1.23 0 -5.2 0 miRNATAP -0.74 0 NA
6 hsa-miR-181c-5p ACVR1C 0.57 0 -5.2 0 miRNATAP -0.58 0 NA
7 hsa-miR-200b-3p ACVR1C 2.12 0 -5.2 0 TargetScan -0.69 0 NA
8 hsa-miR-331-5p ACVR1C 0.68 0 -5.2 0 miRNATAP -0.6 0 NA
9 hsa-miR-429 ACVR1C 2.84 0 -5.2 0 PITA; miRanda; miRNATAP -0.7 0 NA
10 hsa-miR-590-3p ACVR1C 1.27 0 -5.2 0 miRanda -0.58 0 NA
11 hsa-miR-590-5p ACVR1C 0.75 0 -5.2 0 PITA; miRanda -0.45 0 NA
12 hsa-miR-98-5p ACVR1C 0.66 0 -5.2 0 MirTarget -0.79 0 NA
13 hsa-miR-15a-5p ACVR2A 0.81 0 -0.96 0 MirTarget; miRNATAP -0.37 0 NA
14 hsa-miR-185-5p ACVR2A 0.48 0 -0.96 0 miRNATAP -0.31 0 NA
15 hsa-miR-429 BMP2 2.84 0 -2.66 0 miRNATAP -0.41 0 NA
16 hsa-miR-590-3p BMP4 1.27 0 -1.1 0 miRanda -0.49 0 NA
17 hsa-miR-340-5p BMP5 1.09 0 -4.21 0 mirMAP -0.3 0.0042 NA
18 hsa-miR-590-3p BMP5 1.27 0 -4.21 0 mirMAP -0.43 0 NA
19 hsa-miR-30c-5p BMP7 -0.39 8.0E-5 -0.57 0.0198 mirMAP; miRNATAP -0.35 2.0E-5 NA
20 hsa-miR-342-3p BMP7 1.22 0 -0.57 0.0198 miRNAWalker2 validate; miRTarBase; miRanda -0.4 0 NA
21 hsa-miR-30e-3p BMP8A -0.71 0 2.55 0 MirTarget -0.53 0 NA
22 hsa-miR-125b-5p BMPR1B -1.94 0 2.33 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.52 0 19738052; 21556765 A risk variant in an miR 125b binding site in BMPR1B is associated with breast cancer pathogenesis; Furthermore luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536; These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk;Our findings show that rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years
23 hsa-miR-130a-3p BMPR1B -1.15 0 2.33 0 miRNATAP -0.47 0 NA
24 hsa-miR-130b-3p BMPR1B 1.38 0 2.33 0 miRNATAP -0.33 0.00111 NA
25 hsa-miR-140-3p BMPR1B -1.26 0 2.33 0 MirTarget -0.9 0 NA
26 hsa-miR-142-5p BMPR1B 1.17 0 2.33 0 mirMAP -0.44 0 NA
27 hsa-miR-146b-5p BMPR1B 0.63 0 2.33 0 miRanda -0.76 0 NA
28 hsa-miR-150-5p BMPR1B -0.83 3.0E-5 2.33 0 MirTarget -0.45 0 NA
29 hsa-miR-23a-3p BMPR1B -0.22 0.00963 2.33 0 mirMAP -0.54 0.00078 NA
30 hsa-miR-24-3p BMPR1B -0.12 0.21432 2.33 0 miRNATAP -0.92 0 NA
31 hsa-miR-26a-5p BMPR1B -0.48 0 2.33 0 mirMAP -0.5 0.0047 NA
32 hsa-miR-374a-5p BMPR1B -0.24 0.0031 2.33 0 MirTarget -1.35 0 NA
33 hsa-miR-374b-5p BMPR1B -0.47 0 2.33 0 MirTarget -1.21 0 NA
34 hsa-miR-576-5p BMPR1B 0.06 0.58879 2.33 0 mirMAP -0.44 9.0E-5 NA
35 hsa-miR-889-3p BMPR1B -0.38 0.00501 2.33 0 MirTarget -0.51 0 NA
36 hsa-miR-185-5p BMPR2 0.48 0 -0.62 0 MirTarget -0.34 0 NA
37 hsa-miR-361-5p BMPR2 -0.1 0.09543 -0.62 0 MirTarget; miRanda; mirMAP; miRNATAP -0.33 0 NA
38 hsa-let-7d-5p CHRD 0.41 1.0E-5 0.64 0.00226 MirTarget; miRNATAP -0.77 0 NA
39 hsa-let-7g-3p CHRD 0.59 0.00037 0.64 0.00226 MirTarget -0.39 0 NA
40 hsa-let-7g-5p CHRD 0.02 0.79164 0.64 0.00226 MirTarget; miRNATAP -0.7 0 NA
41 hsa-let-7i-5p CHRD -0.33 0 0.64 0.00226 MirTarget; miRNATAP -0.94 0 NA
42 hsa-miR-455-3p CHRD 0.68 0.00033 0.64 0.00226 miRNATAP -0.39 0 NA
43 hsa-miR-98-5p CHRD 0.66 0 0.64 0.00226 MirTarget -0.73 0 NA
44 hsa-let-7d-5p DCN 0.41 1.0E-5 -2.24 0 MirTarget -0.4 0 NA
45 hsa-let-7g-5p DCN 0.02 0.79164 -2.24 0 MirTarget -0.3 0.00045 NA
46 hsa-miR-181b-5p DCN 1.23 0 -2.24 0 MirTarget -0.4 0 NA
47 hsa-miR-181d-5p DCN 0.78 0 -2.24 0 MirTarget -0.32 0 NA
48 hsa-miR-590-3p DCN 1.27 0 -2.24 0 MirTarget; PITA; miRanda; mirMAP -0.53 0 NA
49 hsa-miR-7-1-3p DCN 0.69 0 -2.24 0 mirMAP -0.42 0 NA
50 hsa-miR-98-5p DCN 0.66 0 -2.24 0 MirTarget -0.69 0 NA
51 hsa-miR-199a-5p E2F5 -0.31 0.00909 1.22 0 miRanda -0.3 0 NA
52 hsa-miR-199b-5p E2F5 -1.37 0 1.22 0 miRanda -0.34 0 NA
53 hsa-miR-590-3p FST 1.27 0 -0.9 0 miRanda -0.46 0 NA
54 hsa-miR-769-5p FST 0.56 0 -0.9 0 MirTarget; miRNATAP -0.58 0 NA
55 hsa-miR-342-3p GDF5 1.22 0 -2.29 0 miRanda -0.51 0 NA
56 hsa-miR-192-5p ID1 1.33 0 -1.08 0 miRNAWalker2 validate -0.38 0 NA
57 hsa-miR-331-3p ID1 0.74 0 -1.08 0 MirTarget -0.39 0 NA
58 hsa-miR-192-5p ID4 1.33 0 -2.96 0 miRNAWalker2 validate -0.4 0 NA
59 hsa-miR-330-5p ID4 0.63 0 -2.96 0 miRanda -0.34 0 NA
60 hsa-miR-342-3p ID4 1.22 0 -2.96 0 MirTarget; PITA; miRanda -0.56 0 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4
61 hsa-miR-629-3p ID4 1.25 0 -2.96 0 MirTarget -0.38 0 NA
62 hsa-miR-125a-5p IFNG -0.64 0 0.47 0.06598 miRanda -0.63 0 NA
63 hsa-miR-10b-5p INHBA -2.11 0 2.92 0 miRNAWalker2 validate -0.32 0 NA
64 hsa-miR-126-5p INHBA -1.28 0 2.92 0 mirMAP -0.37 0 NA
65 hsa-miR-195-3p INHBA -1.5 0 2.92 0 mirMAP -0.46 0 NA
66 hsa-miR-26a-5p INHBA -0.48 0 2.92 0 mirMAP -0.81 0 NA
67 hsa-miR-26b-5p INHBA -0.33 0.00055 2.92 0 mirMAP -0.39 0 NA
68 hsa-miR-30a-5p INHBA -0.39 0.00955 2.92 0 mirMAP -0.34 0 NA
69 hsa-miR-30b-5p INHBA -0.47 2.0E-5 2.92 0 mirMAP -0.49 0 NA
70 hsa-miR-30c-5p INHBA -0.39 8.0E-5 2.92 0 mirMAP -0.55 0 NA
71 hsa-miR-30d-5p INHBA -0.25 0.00407 2.92 0 mirMAP -0.56 0 NA
72 hsa-miR-335-3p INHBA -1.88 0 2.92 0 mirMAP -0.36 0 NA
73 hsa-miR-374a-5p INHBA -0.24 0.0031 2.92 0 mirMAP -0.5 0 NA
74 hsa-miR-374b-5p INHBA -0.47 0 2.92 0 mirMAP -0.42 0 NA
75 hsa-miR-664a-3p INHBA -0.24 0.01971 2.92 0 mirMAP -0.33 0 NA
76 hsa-let-7a-3p INHBB 0.47 0 -1.41 0 mirMAP -0.33 0 NA
77 hsa-miR-130b-3p INHBB 1.38 0 -1.41 0 miRNATAP -0.38 0 NA
78 hsa-miR-130b-5p INHBB 1.06 0 -1.41 0 mirMAP -0.31 0 NA
79 hsa-miR-454-3p INHBB 1.28 0 -1.41 0 miRNATAP -0.3 0 NA
80 hsa-miR-590-3p INHBB 1.27 0 -1.41 0 miRanda -0.37 0 NA
81 hsa-miR-590-5p INHBB 0.75 0 -1.41 0 miRanda -0.32 0 NA
82 hsa-miR-192-5p LEFTY2 1.33 0 -2.24 0 MirTarget -0.64 0 NA
83 hsa-miR-339-5p LEFTY2 -0.21 0.06859 -2.24 0 miRanda -0.38 1.0E-5 NA
84 hsa-miR-625-5p LEFTY2 0.73 0 -2.24 0 MirTarget -0.59 0 NA
85 hsa-miR-148b-3p NOG 1.06 0 -0.84 4.0E-5 MirTarget -0.58 0 NA
86 hsa-miR-200c-3p NOG 2.07 0 -0.84 4.0E-5 MirTarget; miRNATAP -0.35 0 NA
87 hsa-miR-30d-3p PITX2 0.26 0.00755 -0.45 0.02044 miRNATAP -0.33 0 NA
88 hsa-miR-342-3p PITX2 1.22 0 -0.45 0.02044 miRanda -0.31 0 NA
89 hsa-miR-340-5p ROCK2 1.09 0 -1.42 0 mirMAP -0.4 0 NA
90 hsa-miR-361-5p RPS6KB1 -0.1 0.09543 -0.06 0.49809 miRanda -0.32 0 NA
91 hsa-let-7a-3p SMAD9 0.47 0 -2.32 0 mirMAP -0.34 0 NA
92 hsa-miR-106b-5p SMAD9 1.22 0 -2.32 0 miRNAWalker2 validate; mirMAP -0.49 0 NA
93 hsa-miR-200b-3p SMAD9 2.12 0 -2.32 0 TargetScan -0.43 0 NA
94 hsa-miR-429 SMAD9 2.84 0 -2.32 0 miRanda; miRNATAP -0.41 0 NA
95 hsa-miR-590-3p SMAD9 1.27 0 -2.32 0 mirMAP -0.31 0 NA
96 hsa-miR-93-5p SMAD9 1.02 0 -2.32 0 mirMAP -0.54 0 NA
97 hsa-miR-107 TGFB2 0.68 0 -0.57 0.00207 miRanda -0.4 0 NA
98 hsa-miR-148b-3p TGFB2 1.06 0 -0.57 0.00207 MirTarget -0.42 0 NA
99 hsa-miR-193a-3p TGFB2 0.31 0.00478 -0.57 0.00207 MirTarget; miRanda; miRNATAP -0.39 0 NA
100 hsa-miR-29b-3p TGFB2 0.44 6.0E-5 -0.57 0.00207 miRTarBase; MirTarget; miRNATAP -0.44 0 NA
101 hsa-miR-29c-3p TGFB2 -0.07 0.56377 -0.57 0.00207 MirTarget; miRNATAP -0.39 0 NA
102 hsa-miR-151a-5p TGFB3 0.51 0 0.82 0 MirTarget -0.46 0 NA
103 hsa-miR-29b-3p TGFB3 0.44 6.0E-5 0.82 0 miRTarBase -0.3 0 NA
104 hsa-miR-361-5p TGFBR1 -0.1 0.09543 -0.28 0.00374 miRanda; mirMAP; miRNATAP -0.34 0 NA
105 hsa-miR-106b-5p TGFBR2 1.22 0 -2.4 0 miRNATAP -0.58 0 NA
106 hsa-miR-107 TGFBR2 0.68 0 -2.4 0 miRanda; miRNATAP -0.53 0 NA
107 hsa-miR-130b-3p TGFBR2 1.38 0 -2.4 0 miRNAWalker2 validate; miRNATAP -0.36 0 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC
108 hsa-miR-17-5p TGFBR2 0.6 1.0E-5 -2.4 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.34 0 25011053; 27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer
109 hsa-miR-20a-5p TGFBR2 0.45 0.0006 -2.4 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.35 0 NA
110 hsa-miR-21-5p TGFBR2 2.32 0 -2.4 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.54 0 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway
111 hsa-miR-301a-3p TGFBR2 1.32 0 -2.4 0 miRNATAP -0.32 0 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2
112 hsa-miR-340-5p TGFBR2 1.09 0 -2.4 0 mirMAP -0.31 0 NA
113 hsa-miR-429 TGFBR2 2.84 0 -2.4 0 miRNATAP -0.4 0 NA
114 hsa-miR-454-3p TGFBR2 1.28 0 -2.4 0 miRNATAP -0.38 0 NA
115 hsa-miR-590-3p TGFBR2 1.27 0 -2.4 0 miRanda -0.34 0 NA
116 hsa-miR-93-5p TGFBR2 1.02 0 -2.4 0 miRNAWalker2 validate; miRNATAP -0.61 0 NA
117 hsa-miR-20a-5p THBS1 0.45 0.0006 -0.06 0.62139 miRNAWalker2 validate -0.31 0 NA
118 hsa-miR-106b-5p THBS2 1.22 0 0.77 0 MirTarget -0.3 0 NA
119 hsa-miR-20a-5p THBS2 0.45 0.0006 0.77 0 MirTarget -0.34 0 NA
120 hsa-miR-29a-3p THBS2 -0.7 0 0.77 0 MirTarget -0.33 0 NA
121 hsa-miR-29b-3p THBS2 0.44 6.0E-5 0.77 0 MirTarget -0.44 0 NA
122 hsa-miR-29c-3p THBS2 -0.07 0.56377 0.77 0 MirTarget -0.43 0 NA
123 hsa-miR-320b THBS4 0.41 0.00113 -0.66 0.00787 miRanda -0.43 0 NA
124 hsa-miR-361-5p ZFYVE16 -0.1 0.09543 -0.16 0.03339 miRanda -0.33 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 23 190 2.035e-39 9.471e-36
2 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 16 60 1.02e-32 2.373e-29
3 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 20 207 9.558e-32 1.112e-28
4 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 15 48 7.904e-32 1.112e-28
5 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 16 100 8.871e-29 8.255e-26
6 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 24 689 5.003e-28 3.88e-25
7 RESPONSE TO GROWTH FACTOR 21 475 3.487e-26 2.318e-23
8 RESPONSE TO ENDOGENOUS STIMULUS 27 1450 4.42e-25 2.571e-22
9 RESPONSE TO BMP 14 94 1.203e-24 5.598e-22
10 CELLULAR RESPONSE TO BMP STIMULUS 14 94 1.203e-24 5.598e-22
11 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 24 1008 4.486e-24 1.897e-21
12 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 27 1672 1.971e-23 7.644e-21
13 SMAD PROTEIN SIGNAL TRANSDUCTION 12 56 3.435e-23 1.23e-20
14 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 23 983 1.07e-22 3.555e-20
15 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 26 1848 9.495e-21 2.945e-18
16 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 20 801 7.334e-20 2.133e-17
17 SKELETAL SYSTEM DEVELOPMENT 17 455 1.425e-19 3.901e-17
18 REGULATION OF OSSIFICATION 13 178 1.112e-18 2.875e-16
19 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 21 1142 2.954e-18 7.235e-16
20 CONNECTIVE TISSUE DEVELOPMENT 13 194 3.481e-18 8.1e-16
21 CARTILAGE DEVELOPMENT 12 147 7.515e-18 1.589e-15
22 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 22 1395 7.509e-18 1.589e-15
23 REGULATION OF PHOSPHORUS METABOLIC PROCESS 23 1618 7.88e-18 1.594e-15
24 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 20 1036 1.129e-17 2.1e-15
25 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1036 1.129e-17 2.1e-15
26 REGULATION OF OSTEOBLAST DIFFERENTIATION 11 112 2.637e-17 4.636e-15
27 REGULATION OF PROTEIN MODIFICATION PROCESS 23 1710 2.69e-17 4.636e-15
28 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1492 3.138e-17 5.214e-15
29 REGULATION OF CELL PROLIFERATION 22 1496 3.321e-17 5.329e-15
30 POSITIVE REGULATION OF GENE EXPRESSION 23 1733 3.617e-17 5.429e-15
31 REGULATION OF CELLULAR COMPONENT MOVEMENT 18 771 3.594e-17 5.429e-15
32 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 20 1135 6.639e-17 9.653e-15
33 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 1784 6.873e-17 9.691e-15
34 POSITIVE REGULATION OF OSSIFICATION 10 84 1.186e-16 1.623e-14
35 CELL DEVELOPMENT 21 1426 2.696e-16 3.584e-14
36 TISSUE DEVELOPMENT 21 1518 9.509e-16 1.229e-13
37 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 8 38 1.353e-15 1.701e-13
38 NEGATIVE REGULATION OF CELL PROLIFERATION 16 643 1.396e-15 1.709e-13
39 ACTIVIN RECEPTOR SIGNALING PATHWAY 7 22 3.553e-15 4.239e-13
40 NEGATIVE REGULATION OF CELL COMMUNICATION 19 1192 3.679e-15 4.28e-13
41 ORGAN MORPHOGENESIS 17 841 4.085e-15 4.636e-13
42 REGULATION OF CELL DEATH 20 1472 9.847e-15 1.091e-12
43 REGULATION OF CELL DIFFERENTIATION 20 1492 1.274e-14 1.378e-12
44 REGULATION OF EPITHELIAL CELL PROLIFERATION 12 285 2.307e-14 2.44e-12
45 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 21 1805 3.043e-14 3.146e-12
46 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 9 95 3.971e-14 4.017e-12
47 GROWTH 13 410 5.873e-14 5.814e-12
48 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 6.899e-14 6.688e-12
49 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1004 7.437e-14 6.997e-12
50 PATTERN SPECIFICATION PROCESS 13 418 7.518e-14 6.997e-12
51 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 11 229 7.912e-14 7.219e-12
52 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 17 1021 9.776e-14 8.747e-12
53 REGULATION OF CARTILAGE DEVELOPMENT 8 63 1.041e-13 9.136e-12
54 POSITIVE REGULATION OF RESPONSE TO STIMULUS 21 1929 1.137e-13 9.8e-12
55 POSITIVE REGULATION OF CELL COMMUNICATION 19 1532 3.453e-13 2.869e-11
56 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 14 602 3.449e-13 2.869e-11
57 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 8 75 4.471e-13 3.649e-11
58 POSITIVE REGULATION OF CELL PROLIFERATION 15 814 1.105e-12 8.868e-11
59 REGULATION OF MAPK CASCADE 14 660 1.199e-12 9.453e-11
60 POSITIVE REGULATION OF CELL DIFFERENTIATION 15 823 1.295e-12 1.004e-10
61 REPRODUCTIVE SYSTEM DEVELOPMENT 12 408 1.618e-12 1.217e-10
62 REGULATION OF CELL DEVELOPMENT 15 836 1.621e-12 1.217e-10
63 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 9 144 1.818e-12 1.343e-10
64 EMBRYONIC MORPHOGENESIS 13 539 1.895e-12 1.378e-10
65 POSITIVE REGULATION OF LOCOMOTION 12 420 2.273e-12 1.627e-10
66 TUBE DEVELOPMENT 13 552 2.559e-12 1.804e-10
67 GASTRULATION 9 155 3.547e-12 2.464e-10
68 EMBRYO DEVELOPMENT 15 894 4.238e-12 2.9e-10
69 REPRODUCTION 17 1297 4.652e-12 3.137e-10
70 NEGATIVE REGULATION OF CELL DIFFERENTIATION 13 609 8.791e-12 5.843e-10
71 EPITHELIUM DEVELOPMENT 15 945 9.349e-12 6.127e-10
72 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 13 1.331e-11 8.599e-10
73 SENSORY ORGAN DEVELOPMENT 12 493 1.477e-11 9.412e-10
74 MESODERM MORPHOGENESIS 7 66 1.54e-11 9.683e-10
75 MESODERM DEVELOPMENT 8 118 1.844e-11 1.144e-09
76 TISSUE MORPHOGENESIS 12 533 3.65e-11 2.229e-09
77 SKELETAL SYSTEM MORPHOGENESIS 9 201 3.689e-11 2.229e-09
78 MESENCHYMAL CELL DIFFERENTIATION 8 134 5.156e-11 3.076e-09
79 HEAD DEVELOPMENT 13 709 5.845e-11 3.443e-09
80 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 7 80 6.179e-11 3.594e-09
81 RESPONSE TO LIPID 14 888 6.35e-11 3.648e-09
82 RESPONSE TO ORGANIC CYCLIC COMPOUND 14 917 9.714e-11 5.512e-09
83 REGULATION OF VASCULATURE DEVELOPMENT 9 233 1.379e-10 7.731e-09
84 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 8 153 1.497e-10 8.29e-09
85 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 154 1.577e-10 8.531e-09
86 POSITIVE REGULATION OF CELL DEATH 12 605 1.572e-10 8.531e-09
87 BONE DEVELOPMENT 8 156 1.748e-10 9.351e-09
88 NEUROGENESIS 16 1402 2.057e-10 1.088e-08
89 GLAND MORPHOGENESIS 7 97 2.449e-10 1.28e-08
90 REGULATION OF EPITHELIAL CELL MIGRATION 8 166 2.873e-10 1.485e-08
91 REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 363 3.052e-10 1.561e-08
92 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 7 102 3.499e-10 1.77e-08
93 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 7 103 3.75e-10 1.876e-08
94 ODONTOGENESIS 7 105 4.298e-10 2.127e-08
95 FORMATION OF PRIMARY GERM LAYER 7 110 5.973e-10 2.926e-08
96 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 5 26 6.695e-10 3.245e-08
97 GLAND DEVELOPMENT 10 395 6.928e-10 3.323e-08
98 CHONDROCYTE DIFFERENTIATION 6 60 7.104e-10 3.373e-08
99 REGULATION OF STEM CELL DIFFERENTIATION 7 113 7.223e-10 3.395e-08
100 MESENCHYME DEVELOPMENT 8 190 8.412e-10 3.875e-08
101 STEM CELL DIFFERENTIATION 8 190 8.412e-10 3.875e-08
102 EMBRYONIC ORGAN DEVELOPMENT 10 406 9.035e-10 4.122e-08
103 RESPONSE TO HORMONE 13 893 9.972e-10 4.505e-08
104 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 11 554 1.072e-09 4.795e-08
105 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 7 121 1.17e-09 5.184e-08
106 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 5 29 1.204e-09 5.279e-08
107 RHYTHMIC PROCESS 9 298 1.214e-09 5.279e-08
108 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 7 122 1.24e-09 5.34e-08
109 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 67 1.404e-09 5.994e-08
110 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 15 1360 1.542e-09 6.524e-08
111 REGIONALIZATION 9 311 1.766e-09 7.402e-08
112 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 12 750 1.819e-09 7.555e-08
113 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.905e-09 7.844e-08
114 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 1152 1.922e-09 7.845e-08
115 PROTEIN PHOSPHORYLATION 13 944 1.959e-09 7.925e-08
116 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 13 957 2.312e-09 9.273e-08
117 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 16 1656 2.376e-09 9.448e-08
118 EYE DEVELOPMENT 9 326 2.667e-09 1.052e-07
119 REGULATION OF BMP SIGNALING PATHWAY 6 77 3.296e-09 1.289e-07
120 POSITIVE REGULATION OF CELL DEVELOPMENT 10 472 3.847e-09 1.492e-07
121 OVULATION CYCLE PROCESS 6 88 7.435e-09 2.859e-07
122 OSSIFICATION 8 251 7.539e-09 2.875e-07
123 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 6 93 1.04e-08 3.933e-07
124 MORPHOGENESIS OF A BRANCHING STRUCTURE 7 167 1.11e-08 4.165e-07
125 SEX DIFFERENTIATION 8 266 1.186e-08 4.416e-07
126 APPENDAGE DEVELOPMENT 7 169 1.206e-08 4.417e-07
127 LIMB DEVELOPMENT 7 169 1.206e-08 4.417e-07
128 LUNG MORPHOGENESIS 5 45 1.215e-08 4.418e-07
129 LOCOMOTION 13 1114 1.436e-08 5.14e-07
130 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 6 98 1.427e-08 5.14e-07
131 MORPHOGENESIS OF AN EPITHELIUM 9 400 1.577e-08 5.603e-07
132 EMBRYONIC ORGAN MORPHOGENESIS 8 279 1.72e-08 6.063e-07
133 REGULATION OF NEURON DIFFERENTIATION 10 554 1.768e-08 6.184e-07
134 ANGIOGENESIS 8 293 2.516e-08 8.736e-07
135 UROGENITAL SYSTEM DEVELOPMENT 8 299 2.944e-08 1.015e-06
136 MULTICELLULAR ORGANISM REPRODUCTION 11 768 3.177e-08 1.087e-06
137 OVULATION CYCLE 6 113 3.364e-08 1.142e-06
138 RESPIRATORY SYSTEM DEVELOPMENT 7 197 3.473e-08 1.171e-06
139 EPITHELIAL TO MESENCHYMAL TRANSITION 5 56 3.749e-08 1.255e-06
140 PHOSPHORYLATION 13 1228 4.564e-08 1.517e-06
141 ENDOCRINE SYSTEM DEVELOPMENT 6 123 5.59e-08 1.845e-06
142 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 9 465 5.751e-08 1.885e-06
143 REGULATION OF GROWTH 10 633 6.202e-08 2.004e-06
144 VASCULATURE DEVELOPMENT 9 469 6.188e-08 2.004e-06
145 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 7 216 6.53e-08 2.095e-06
146 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 337 7.413e-08 2.362e-06
147 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 6 131 8.142e-08 2.577e-06
148 RESPONSE TO STEROID HORMONE 9 497 1.014e-07 3.168e-06
149 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 5 68 1.008e-07 3.168e-06
150 NEGATIVE REGULATION OF CELL DEATH 11 872 1.157e-07 3.565e-06
151 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 1.157e-07 3.565e-06
152 NEURON DIFFERENTIATION 11 874 1.184e-07 3.625e-06
153 NEGATIVE REGULATION OF GROWTH 7 236 1.195e-07 3.635e-06
154 BLOOD VESSEL MORPHOGENESIS 8 364 1.339e-07 4.046e-06
155 REGULATION OF ORGAN MORPHOGENESIS 7 242 1.418e-07 4.256e-06
156 REGULATION OF HEART MORPHOGENESIS 4 29 1.604e-07 4.784e-06
157 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 1.867e-07 5.533e-06
158 BONE MORPHOGENESIS 5 79 2.151e-07 6.336e-06
159 PROTEIN LOCALIZATION TO NUCLEUS 6 156 2.296e-07 6.719e-06
160 ENDOCARDIAL CUSHION DEVELOPMENT 4 32 2.42e-07 7.023e-06
161 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 262 2.43e-07 7.023e-06
162 REGULATION OF CELL CYCLE 11 949 2.712e-07 7.789e-06
163 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 8 404 2.965e-07 8.464e-06
164 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 4 34 3.113e-07 8.778e-06
165 HEART VALVE DEVELOPMENT 4 34 3.113e-07 8.778e-06
166 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 3.716e-07 1.042e-05
167 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 36 3.944e-07 1.086e-05
168 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 36 3.944e-07 1.086e-05
169 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 171 3.946e-07 1.086e-05
170 REGULATION OF BINDING 7 283 4.091e-07 1.12e-05
171 MESONEPHROS DEVELOPMENT 5 90 4.14e-07 1.126e-05
172 CARDIOVASCULAR SYSTEM DEVELOPMENT 10 788 4.726e-07 1.271e-05
173 CIRCULATORY SYSTEM DEVELOPMENT 10 788 4.726e-07 1.271e-05
174 NEGATIVE REGULATION OF CELL CYCLE 8 433 5.014e-07 1.341e-05
175 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 437 5.375e-07 1.429e-05
176 RESPONSE TO KETONE 6 182 5.691e-07 1.504e-05
177 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 5.758e-07 1.514e-05
178 RESPONSE TO EXTERNAL STIMULUS 14 1821 6.18e-07 1.616e-05
179 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 98 6.335e-07 1.638e-05
180 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 6.304e-07 1.638e-05
181 NEGATIVE REGULATION OF CELL DEVELOPMENT 7 303 6.475e-07 1.664e-05
182 POSITIVE REGULATION OF NEURON DIFFERENTIATION 7 306 6.917e-07 1.768e-05
183 REGULATION OF CELL ADHESION 9 629 7.375e-07 1.875e-05
184 PITUITARY GLAND DEVELOPMENT 4 42 7.441e-07 1.882e-05
185 IN UTERO EMBRYONIC DEVELOPMENT 7 311 7.711e-07 1.939e-05
186 REGULATION OF MUSCLE TISSUE DEVELOPMENT 5 103 8.117e-07 2.02e-05
187 REGULATION OF MUSCLE ORGAN DEVELOPMENT 5 103 8.117e-07 2.02e-05
188 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 8.27e-07 2.047e-05
189 HEART DEVELOPMENT 8 466 8.721e-07 2.147e-05
190 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 12 9.772e-07 2.393e-05
191 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 200 9.88e-07 2.394e-05
192 ENDOCHONDRAL BONE MORPHOGENESIS 4 45 9.87e-07 2.394e-05
193 TUBE MORPHOGENESIS 7 323 9.933e-07 2.395e-05
194 REGULATION OF CHONDROCYTE DIFFERENTIATION 4 46 1.08e-06 2.576e-05
195 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 4 46 1.08e-06 2.576e-05
196 MESENCHYMAL CELL PROLIFERATION 3 13 1.269e-06 3.012e-05
197 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 1.284e-06 3.033e-05
198 REGULATION OF ENDOTHELIAL CELL MIGRATION 5 114 1.343e-06 3.156e-05
199 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 6 211 1.35e-06 3.156e-05
200 EPITHELIAL CELL DIFFERENTIATION 8 495 1.371e-06 3.19e-05
201 HEART MORPHOGENESIS 6 212 1.387e-06 3.212e-05
202 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 5 115 1.403e-06 3.231e-05
203 MULTI ORGANISM REPRODUCTIVE PROCESS 10 891 1.447e-06 3.317e-05
204 FEMALE SEX DIFFERENTIATION 5 116 1.464e-06 3.339e-05
205 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 4 50 1.516e-06 3.442e-05
206 REGULATION OF GLOMERULUS DEVELOPMENT 3 14 1.613e-06 3.626e-05
207 EMBRYONIC SKELETAL JOINT DEVELOPMENT 3 14 1.613e-06 3.626e-05
208 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 513 1.79e-06 4.005e-05
209 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 1.921e-06 4.277e-05
210 FOREBRAIN DEVELOPMENT 7 357 1.934e-06 4.285e-05
211 KIDNEY EPITHELIUM DEVELOPMENT 5 125 2.118e-06 4.655e-05
212 RESPONSE TO ALCOHOL 7 362 2.121e-06 4.655e-05
213 CRANIAL SKELETAL SYSTEM DEVELOPMENT 4 55 2.232e-06 4.876e-05
214 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 16 2.476e-06 5.358e-05
215 REGULATION OF REPRODUCTIVE PROCESS 5 129 2.473e-06 5.358e-05
216 REGULATION OF GLIAL CELL DIFFERENTIATION 4 59 2.965e-06 6.386e-05
217 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 3 17 3.003e-06 6.439e-05
218 REGULATION OF CELL MORPHOGENESIS 8 552 3.085e-06 6.585e-05
219 STEM CELL PROLIFERATION 4 60 3.173e-06 6.741e-05
220 OVARIAN FOLLICLE DEVELOPMENT 4 61 3.391e-06 7.172e-05
221 RESPONSE TO WOUNDING 8 563 3.57e-06 7.516e-05
222 REGULATION OF TRANSPORT 13 1804 3.798e-06 7.96e-05
223 REGULATION OF EPIDERMIS DEVELOPMENT 4 63 3.861e-06 8.057e-05
224 REGULATION OF KINASE ACTIVITY 9 776 4.167e-06 8.656e-05
225 ATRIOVENTRICULAR VALVE DEVELOPMENT 3 19 4.269e-06 8.829e-05
226 IMMUNE SYSTEM DEVELOPMENT 8 582 4.56e-06 9.388e-05
227 NEGATIVE REGULATION OF LOCOMOTION 6 263 4.822e-06 9.861e-05
228 DIGESTIVE SYSTEM DEVELOPMENT 5 148 4.853e-06 9.861e-05
229 MALE SEX DIFFERENTIATION 5 148 4.853e-06 9.861e-05
230 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 4 67 4.945e-06 1e-04
231 NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 3 20 5.017e-06 0.0001011
232 RESPONSE TO ABIOTIC STIMULUS 10 1024 5.039e-06 0.0001011
233 CHONDROCYTE DEVELOPMENT 3 21 5.846e-06 0.0001167
234 CELL CYCLE ARREST 5 154 5.893e-06 0.0001172
235 MUSCLE TISSUE DEVELOPMENT 6 275 6.228e-06 0.0001233
236 NEGATIVE REGULATION OF HORMONE SECRETION 4 74 7.361e-06 0.0001451
237 CELL MOTILITY 9 835 7.552e-06 0.000147
238 LOCALIZATION OF CELL 9 835 7.552e-06 0.000147
239 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 7.543e-06 0.000147
240 PROSTATE GLAND MORPHOGENESIS 3 23 7.767e-06 0.00015
241 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 4 75 7.767e-06 0.00015
242 REGULATION OF DEVELOPMENTAL GROWTH 6 289 8.271e-06 0.000159
243 DIENCEPHALON DEVELOPMENT 4 77 8.627e-06 0.0001652
244 RESPONSE TO STEROL 3 24 8.866e-06 0.0001684
245 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 3 24 8.866e-06 0.0001684
246 REGULATION OF PROTEIN BINDING 5 168 9.001e-06 0.0001703
247 REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY 3 25 1.006e-05 0.0001896
248 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 13 1977 1.044e-05 0.0001959
249 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 303 1.083e-05 0.0002023
250 NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 26 1.136e-05 0.0002115
251 PROTEOGLYCAN METABOLIC PROCESS 4 83 1.163e-05 0.0002156
252 WOUND HEALING 7 470 1.175e-05 0.000217
253 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 3 27 1.277e-05 0.0002333
254 REGULATION OF ASTROCYTE DIFFERENTIATION 3 27 1.277e-05 0.0002333
255 PALATE DEVELOPMENT 4 85 1.278e-05 0.0002333
256 CELL PROLIFERATION 8 672 1.304e-05 0.000237
257 REGULATION OF HORMONE LEVELS 7 478 1.311e-05 0.0002373
258 POSITIVE REGULATION OF KINASE ACTIVITY 7 482 1.383e-05 0.0002485
259 CELLULAR COMPONENT MORPHOGENESIS 9 900 1.379e-05 0.0002485
260 TISSUE REMODELING 4 87 1.402e-05 0.0002509
261 GASTRULATION WITH MOUTH FORMING SECOND 3 28 1.428e-05 0.0002546
262 REGULATION OF MAP KINASE ACTIVITY 6 319 1.45e-05 0.0002575
263 ENDOTHELIUM DEVELOPMENT 4 90 1.604e-05 0.0002826
264 REGULATION OF GLIOGENESIS 4 90 1.604e-05 0.0002826
265 DORSAL VENTRAL PATTERN FORMATION 4 91 1.675e-05 0.0002942
266 SMOOTH MUSCLE CELL DIFFERENTIATION 3 30 1.766e-05 0.0003089
267 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 94 1.905e-05 0.0003319
268 REGULATION OF TRANSFERASE ACTIVITY 9 946 2.052e-05 0.0003563
269 CARDIOCYTE DIFFERENTIATION 4 96 2.07e-05 0.000358
270 SALIVARY GLAND DEVELOPMENT 3 32 2.153e-05 0.0003642
271 REGULATION OF ORGAN FORMATION 3 32 2.153e-05 0.0003642
272 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 3 32 2.153e-05 0.0003642
273 PATTERNING OF BLOOD VESSELS 3 32 2.153e-05 0.0003642
274 POSITIVE REGULATION OF EPIDERMIS DEVELOPMENT 3 32 2.153e-05 0.0003642
275 REGULATION OF PROTEIN LOCALIZATION 9 950 2.122e-05 0.0003642
276 NEGATIVE REGULATION OF GENE EXPRESSION 11 1493 2.218e-05 0.0003739
277 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 99 2.337e-05 0.0003912
278 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 99 2.337e-05 0.0003912
279 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 2.432e-05 0.0004055
280 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 11 1517 2.575e-05 0.0004245
281 ORGAN FORMATION 3 34 2.591e-05 0.0004245
282 REGULATION OF MESENCHYMAL CELL PROLIFERATION 3 34 2.591e-05 0.0004245
283 GERM CELL DEVELOPMENT 5 209 2.583e-05 0.0004245
284 CELLULAR MACROMOLECULE LOCALIZATION 10 1234 2.583e-05 0.0004245
285 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 740 2.612e-05 0.0004265
286 RESPONSE TO MECHANICAL STIMULUS 5 210 2.643e-05 0.0004299
287 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 7 541 2.907e-05 0.0004696
288 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 7 541 2.907e-05 0.0004696
289 HEAD MORPHOGENESIS 3 36 3.084e-05 0.0004966
290 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 218 3.161e-05 0.0005071
291 PLATELET DEGRANULATION 4 107 3.173e-05 0.0005074
292 CELL DEATH 9 1001 3.208e-05 0.0005112
293 CELLULAR RESPONSE TO HORMONE STIMULUS 7 552 3.306e-05 0.0005249
294 NEGATIVE REGULATION OF GLIOGENESIS 3 37 3.353e-05 0.0005288
295 HINDLIMB MORPHOGENESIS 3 37 3.353e-05 0.0005288
296 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 6 372 3.443e-05 0.0005413
297 REGULATION OF CELLULAR LOCALIZATION 10 1277 3.468e-05 0.0005414
298 PROTEIN LOCALIZATION TO ORGANELLE 7 556 3.461e-05 0.0005414
299 REGULATION OF CELL PROJECTION ORGANIZATION 7 558 3.541e-05 0.0005511
300 RESPONSE TO TESTOSTERONE 3 38 3.636e-05 0.000562
301 MESENCHYME MORPHOGENESIS 3 38 3.636e-05 0.000562
302 CELL CYCLE G1 S PHASE TRANSITION 4 111 3.665e-05 0.0005628
303 G1 S TRANSITION OF MITOTIC CELL CYCLE 4 111 3.665e-05 0.0005628
304 CELL FATE COMMITMENT 5 227 3.834e-05 0.0005869
305 GLANDULAR EPITHELIAL CELL DIFFERENTIATION 3 39 3.934e-05 0.0006002
306 NEPHRON DEVELOPMENT 4 115 4.211e-05 0.0006402
307 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 40 4.248e-05 0.0006439
308 REGULATION OF PROTEIN SECRETION 6 389 4.418e-05 0.0006675
309 SPECIFICATION OF SYMMETRY 4 117 4.504e-05 0.0006783
310 PROSTATE GLAND DEVELOPMENT 3 41 4.578e-05 0.000685
311 LUNG ALVEOLUS DEVELOPMENT 3 41 4.578e-05 0.000685
312 POSITIVE REGULATION OF GROWTH 5 238 4.803e-05 0.0007164
313 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 3 43 5.288e-05 0.0007861
314 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 5.305e-05 0.0007861
315 GAMETE GENERATION 7 595 5.322e-05 0.0007862
316 BODY MORPHOGENESIS 3 44 5.668e-05 0.0008346
317 CELL CYCLE PROCESS 9 1081 5.854e-05 0.0008592
318 OSTEOBLAST DIFFERENTIATION 4 126 6.016e-05 0.0008803
319 EXOCRINE SYSTEM DEVELOPMENT 3 45 6.066e-05 0.000882
320 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 6.066e-05 0.000882
321 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1087 6.111e-05 0.0008858
322 POSITIVE REGULATION OF BINDING 4 127 6.204e-05 0.0008965
323 REGULATION OF PHOSPHATASE ACTIVITY 4 128 6.397e-05 0.0009215
324 PEPTIDYL THREONINE MODIFICATION 3 46 6.482e-05 0.0009308
325 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 129 6.594e-05 0.0009411
326 NUCLEAR IMPORT 4 129 6.594e-05 0.0009411
327 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 7 616 6.624e-05 0.0009426
328 REGULATION OF PEPTIDE TRANSPORT 5 256 6.787e-05 0.0009628
329 REGULATION OF LYMPHOCYTE DIFFERENTIATION 4 132 7.21e-05 0.00102
330 REGULATION OF HORMONE SECRETION 5 262 7.573e-05 0.001068
331 REGULATION OF IMMUNE SYSTEM PROCESS 10 1403 7.716e-05 0.001085
332 NEGATIVE REGULATION OF PEPTIDE SECRETION 3 49 7.839e-05 0.001092
333 RESPONSE TO DRUG 6 431 7.798e-05 0.001092
334 REGULATION OF STEROID BIOSYNTHETIC PROCESS 3 49 7.839e-05 0.001092
335 CELL GROWTH 4 135 7.868e-05 0.001093
336 FACE DEVELOPMENT 3 50 8.33e-05 0.00115
337 RESPONSE TO PROGESTERONE 3 50 8.33e-05 0.00115
338 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 8.627e-05 0.001188
339 REGULATION OF CELL DIVISION 5 272 9.035e-05 0.00124
340 CARDIAC MUSCLE TISSUE DEVELOPMENT 4 140 9.061e-05 0.00124
341 REGULATION OF HOMEOSTATIC PROCESS 6 447 9.531e-05 0.0013
342 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 3 53 9.922e-05 0.001346
343 MESONEPHRIC TUBULE MORPHOGENESIS 3 53 9.922e-05 0.001346
344 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0001049 0.001419
345 CELLULAR RESPONSE TO LIPID 6 457 0.0001076 0.001451
346 NEGATIVE REGULATION OF TRANSPORT 6 458 0.0001089 0.001465
347 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 3 55 0.0001109 0.001482
348 REGULATION OF KIDNEY DEVELOPMENT 3 55 0.0001109 0.001482
349 TAXIS 6 464 0.0001169 0.001559
350 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 152 0.0001245 0.001655
351 POSITIVE REGULATION OF MAPK CASCADE 6 470 0.0001255 0.001658
352 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 470 0.0001255 0.001658
353 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 7 684 0.0001275 0.001681
354 PROTEOGLYCAN BIOSYNTHETIC PROCESS 3 58 0.0001299 0.001708
355 AMEBOIDAL TYPE CELL MIGRATION 4 154 0.000131 0.001717
356 PROTEIN IMPORT 4 155 0.0001343 0.001755
357 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001438 0.001874
358 REGULATION OF DEPHOSPHORYLATION 4 158 0.0001446 0.001879
359 REGULATION OF SECRETION 7 699 0.0001458 0.00189
360 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.000151 0.001952
361 POSITIVE REGULATION OF HAIR CYCLE 2 11 0.0001528 0.001964
362 REGULATION OF ODONTOGENESIS OF DENTIN CONTAINING TOOTH 2 11 0.0001528 0.001964
363 POSITIVE REGULATION OF HEMOPOIESIS 4 163 0.000163 0.002089
364 RESPONSE TO OXYGEN LEVELS 5 311 0.0001692 0.002163
365 REGULATION OF HEMOPOIESIS 5 314 0.0001769 0.002255
366 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE GROWTH 2 12 0.0001832 0.002291
367 POSITIVE REGULATION OF DNA DEPENDENT DNA REPLICATION 2 12 0.0001832 0.002291
368 REGULATION OF MESENCHYMAL CELL APOPTOTIC PROCESS 2 12 0.0001832 0.002291
369 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 2 12 0.0001832 0.002291
370 RESPONSE TO CARBOHYDRATE 4 168 0.000183 0.002291
371 TRACHEA MORPHOGENESIS 2 12 0.0001832 0.002291
372 NEGATIVE REGULATION OF HEART GROWTH 2 12 0.0001832 0.002291
373 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 66 0.0001909 0.002356
374 SEXUAL REPRODUCTION 7 730 0.0001906 0.002356
375 REGULATION OF SYSTEM PROCESS 6 507 0.0001895 0.002356
376 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 66 0.0001909 0.002356
377 LENS DEVELOPMENT IN CAMERA TYPE EYE 3 66 0.0001909 0.002356
378 NEURON FATE COMMITMENT 3 67 0.0001996 0.002457
379 MULTICELLULAR ORGANISMAL RESPONSE TO STRESS 3 68 0.0002086 0.002561
380 NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 2 13 0.0002162 0.002607
381 TYPE B PANCREATIC CELL DEVELOPMENT 2 13 0.0002162 0.002607
382 NEGATIVE REGULATION OF ASTROCYTE DIFFERENTIATION 2 13 0.0002162 0.002607
383 REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT 2 13 0.0002162 0.002607
384 BEHAVIORAL RESPONSE TO PAIN 2 13 0.0002162 0.002607
385 TELENCEPHALON REGIONALIZATION 2 13 0.0002162 0.002607
386 REGULATION OF GONADOTROPIN SECRETION 2 13 0.0002162 0.002607
387 NEGATIVE REGULATION OF OSSIFICATION 3 69 0.0002178 0.002619
388 ENDOTHELIAL CELL DIFFERENTIATION 3 72 0.0002471 0.002963
389 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 2 14 0.000252 0.002999
390 CRANIOFACIAL SUTURE MORPHOGENESIS 2 14 0.000252 0.002999
391 ADENOHYPOPHYSIS DEVELOPMENT 2 14 0.000252 0.002999
392 REGULATION OF PROTEIN IMPORT 4 183 0.0002538 0.003013
393 REGULATION OF DNA METABOLIC PROCESS 5 340 0.0002558 0.003029
394 REGULATION OF CELLULAR COMPONENT BIOGENESIS 7 767 0.0002581 0.003048
395 CELL CYCLE 9 1316 0.0002627 0.003094
396 POSITIVE REGULATION OF DNA METABOLIC PROCESS 4 185 0.0002645 0.003108
397 CARDIAC MUSCLE CELL DIFFERENTIATION 3 74 0.0002679 0.003132
398 REGULATION OF STEROID METABOLIC PROCESS 3 74 0.0002679 0.003132
399 ARTERY DEVELOPMENT 3 75 0.0002788 0.003251
400 REGULATION OF HAIR FOLLICLE DEVELOPMENT 2 15 0.0002905 0.003362
401 POSITIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS 2 15 0.0002905 0.003362
402 VENOUS BLOOD VESSEL DEVELOPMENT 2 15 0.0002905 0.003362
403 RESPONSE TO NUTRIENT 4 191 0.0002987 0.003449
404 REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 552 0.0002996 0.00345
405 GLYCOPROTEIN METABOLIC PROCESS 5 353 0.0003041 0.003494
406 RENAL TUBULE DEVELOPMENT 3 78 0.000313 0.003587
407 EAR DEVELOPMENT 4 195 0.0003232 0.003695
408 REGULATION OF CYTOKINE PRODUCTION 6 563 0.0003329 0.00376
409 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 360 0.0003328 0.00376
410 REGULATION OF MONONUCLEAR CELL MIGRATION 2 16 0.0003316 0.00376
411 ORGAN INDUCTION 2 16 0.0003316 0.00376
412 ATRIOVENTRICULAR VALVE MORPHOGENESIS 2 16 0.0003316 0.00376
413 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 5 361 0.0003371 0.003798
414 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 3 81 0.0003498 0.003931
415 NEGATIVE REGULATION OF SECRETION 4 200 0.0003558 0.003989
416 NEGATIVE REGULATION OF MOLECULAR FUNCTION 8 1079 0.0003612 0.00404
417 KIDNEY MORPHOGENESIS 3 82 0.0003627 0.004047
418 NEGATIVE REGULATION OF KIDNEY DEVELOPMENT 2 17 0.0003754 0.004159
419 NEGATIVE REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 2 17 0.0003754 0.004159
420 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 2 17 0.0003754 0.004159
421 POSITIVE REGULATION OF SECRETION 5 370 0.0003774 0.004171
422 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 3 84 0.0003893 0.004292
423 NEURON PROJECTION GUIDANCE 4 205 0.0003907 0.004297
424 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0004031 0.004423
425 POSITIVE REGULATION OF CELL ADHESION 5 376 0.0004062 0.004447
426 POSITIVE REGULATION OF DNA REPLICATION 3 86 0.0004172 0.004534
427 GLANDULAR EPITHELIAL CELL DEVELOPMENT 2 18 0.0004219 0.004534
428 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 4 209 0.0004203 0.004534
429 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 3 86 0.0004172 0.004534
430 REGULATION OF HORMONE BIOSYNTHETIC PROCESS 2 18 0.0004219 0.004534
431 KIDNEY MESENCHYME DEVELOPMENT 2 18 0.0004219 0.004534
432 PHARYNGEAL SYSTEM DEVELOPMENT 2 18 0.0004219 0.004534
433 REGULATION OF PEPTIDE SECRETION 4 209 0.0004203 0.004534
434 REGULATION OF CELL CELL ADHESION 5 380 0.0004263 0.004571
435 MYELOID CELL HOMEOSTASIS 3 88 0.0004463 0.004763
436 REGULATION OF STEM CELL PROLIFERATION 3 88 0.0004463 0.004763
437 MULTI MULTICELLULAR ORGANISM PROCESS 4 213 0.0004515 0.004807
438 EPITHELIAL CELL PROLIFERATION 3 89 0.0004613 0.0049
439 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 2 19 0.0004711 0.00497
440 ENTEROENDOCRINE CELL DIFFERENTIATION 2 19 0.0004711 0.00497
441 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 2 19 0.0004711 0.00497
442 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 4 216 0.0004759 0.00501
443 RESPONSE TO ESTROGEN 4 218 0.0004927 0.005164
444 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 4 218 0.0004927 0.005164
445 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 220 0.00051 0.005332
446 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 2 20 0.0005228 0.00543
447 TRACHEA DEVELOPMENT 2 20 0.0005228 0.00543
448 REGULATION OF TRANSCRIPTION INVOLVED IN CELL FATE COMMITMENT 2 20 0.0005228 0.00543
449 NEPHRON EPITHELIUM DEVELOPMENT 3 93 0.0005247 0.005437
450 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 6 616 0.0005369 0.005551
451 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 7 867 0.0005412 0.005584
452 REGULATED EXOCYTOSIS 4 224 0.0005457 0.005618
453 NEURON PROJECTION MORPHOGENESIS 5 402 0.0005508 0.005658
454 RESPONSE TO PEPTIDE 5 404 0.0005634 0.005774
455 RESPONSE TO DIETARY EXCESS 2 21 0.0005773 0.005826
456 PROTEIN TARGETING 5 406 0.0005761 0.005826
457 NEGATIVE REGULATION OF ORGAN GROWTH 2 21 0.0005773 0.005826
458 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 5 406 0.0005761 0.005826
459 POSITIVE REGULATION OF MOLECULAR FUNCTION 10 1791 0.0005702 0.005826
460 CELL AGGREGATION 2 21 0.0005773 0.005826
461 CARTILAGE CONDENSATION 2 21 0.0005773 0.005826
462 TELENCEPHALON DEVELOPMENT 4 228 0.0005832 0.005874
463 REGULATION OF NEURON PROJECTION DEVELOPMENT 5 408 0.0005891 0.00592
464 PROTEIN LOCALIZATION 10 1805 0.0006066 0.006083
465 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 3 98 0.0006114 0.006118
466 REGULATION OF LEUKOCYTE DIFFERENTIATION 4 232 0.0006226 0.006203
467 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.0006226 0.006203
468 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 2 22 0.0006343 0.006253
469 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 3 99 0.0006298 0.006253
470 REGULATION OF HAIR CYCLE 2 22 0.0006343 0.006253
471 ENDOCARDIAL CUSHION MORPHOGENESIS 2 22 0.0006343 0.006253
472 REGULATION OF INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 22 0.0006343 0.006253
473 CAMERA TYPE EYE MORPHOGENESIS 3 101 0.0006676 0.006553
474 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 3 101 0.0006676 0.006553
475 MUSCLE CELL DIFFERENTIATION 4 237 0.0006743 0.006605
476 NEGATIVE REGULATION OF PHOSPHORYLATION 5 422 0.0006862 0.006707
477 POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION 2 23 0.000694 0.006727
478 NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 2 23 0.000694 0.006727
479 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.000694 0.006727
480 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.000694 0.006727
481 SENSORY ORGAN MORPHOGENESIS 4 239 0.0006958 0.006731
482 POSITIVE REGULATION OF PROTEIN IMPORT 3 104 0.000727 0.007018
483 NEGATIVE REGULATION OF STEROID METABOLIC PROCESS 2 24 0.0007563 0.007226
484 POSITIVE REGULATION OF CATALYTIC ACTIVITY 9 1518 0.0007512 0.007226
485 POSITIVE REGULATION OF EPITHELIAL CELL APOPTOTIC PROCESS 2 24 0.0007563 0.007226
486 REGULATION OF ODONTOGENESIS 2 24 0.0007563 0.007226
487 ENDOTHELIAL CELL PROLIFERATION 2 24 0.0007563 0.007226
488 MUSCLE STRUCTURE DEVELOPMENT 5 432 0.0007625 0.007271
489 REGULATION OF T CELL DIFFERENTIATION 3 107 0.0007896 0.007513
490 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 5 437 0.000803 0.007626
491 NEGATIVE REGULATION OF PROTEIN SECRETION 3 108 0.0008112 0.007688
492 FOREBRAIN REGIONALIZATION 2 25 0.0008212 0.007719
493 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 2 25 0.0008212 0.007719
494 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 25 0.0008212 0.007719
495 EPITHELIAL CELL APOPTOTIC PROCESS 2 25 0.0008212 0.007719
496 POSITIVE REGULATION OF TRANSPORT 7 936 0.0008527 0.007999
497 DEFENSE RESPONSE 8 1231 0.0008673 0.00812
498 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 3 111 0.0008783 0.008207
499 CELL CYCLE PHASE TRANSITION 4 255 0.000886 0.00822
500 REGULATION OF MESONEPHROS DEVELOPMENT 2 26 0.0008886 0.00822
501 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 2 26 0.0008886 0.00822
502 MESODERMAL CELL DIFFERENTIATION 2 26 0.0008886 0.00822
503 REGULATION OF HORMONE METABOLIC PROCESS 2 26 0.0008886 0.00822
504 DEVELOPMENTAL INDUCTION 2 27 0.0009587 0.008799
505 POSITIVE REGULATION OF FILOPODIUM ASSEMBLY 2 27 0.0009587 0.008799
506 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 2 27 0.0009587 0.008799
507 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 2 27 0.0009587 0.008799
508 AGING 4 264 0.001008 0.009231
509 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 3 117 0.001023 0.009333
510 MAMMARY GLAND DEVELOPMENT 3 117 0.001023 0.009333
511 NEGATIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 2 28 0.001031 0.009373
512 POSITIVE REGULATION OF PHOSPHATASE ACTIVITY 2 28 0.001031 0.009373
513 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 2 29 0.001107 0.009921
514 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 29 0.001107 0.009921
515 RESPONSE TO PAIN 2 29 0.001107 0.009921
516 EMBRYONIC HINDLIMB MORPHOGENESIS 2 29 0.001107 0.009921
517 REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 2 29 0.001107 0.009921
518 POSITIVE REGULATION OF CHEMOTAXIS 3 120 0.001101 0.009921
519 REGULATION OF DENDRITE DEVELOPMENT 3 120 0.001101 0.009921
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 13 50 2.424e-26 2.252e-23
2 CYTOKINE RECEPTOR BINDING 14 271 5.49e-18 2.55e-15
3 GROWTH FACTOR ACTIVITY 12 160 2.13e-17 6.597e-15
4 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 7 17 4.075e-16 9.465e-14
5 CYTOKINE ACTIVITY 12 219 9.738e-16 1.809e-13
6 CYTOKINE BINDING 9 92 2.946e-14 4.562e-12
7 RECEPTOR SERINE THREONINE KINASE BINDING 6 15 7.497e-14 9.949e-12
8 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 8 92 2.418e-12 2.808e-10
9 RECEPTOR SIGNALING PROTEIN ACTIVITY 9 172 9.092e-12 9.385e-10
10 GROWTH FACTOR BINDING 8 123 2.581e-11 2.398e-09
11 TRANSFORMING GROWTH FACTOR BETA BINDING 5 16 4.5e-11 3.8e-09
12 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 7 81 6.755e-11 5.229e-09
13 RECEPTOR BINDING 16 1476 4.4e-10 3.144e-08
14 GLYCOSAMINOGLYCAN BINDING 8 205 1.535e-09 1.019e-07
15 PROTEIN SERINE THREONINE KINASE ACTIVITY 10 445 2.187e-09 1.354e-07
16 PROTEIN KINASE ACTIVITY 10 640 6.874e-08 3.991e-06
17 SULFUR COMPOUND BINDING 7 234 1.128e-07 6.164e-06
18 SMAD BINDING 5 72 1.347e-07 6.952e-06
19 HEPARIN BINDING 6 157 2.384e-07 1.166e-05
20 IDENTICAL PROTEIN BINDING 12 1209 3.565e-07 1.656e-05
21 KINASE ACTIVITY 10 842 8.661e-07 3.831e-05
22 ACTIVIN BINDING 3 12 9.772e-07 4.127e-05
23 PROTEIN DIMERIZATION ACTIVITY 11 1149 1.802e-06 7.28e-05
24 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 992 3.798e-06 0.000147
25 EXTRACELLULAR MATRIX BINDING 3 51 8.84e-05 0.003285
26 PROTEIN COMPLEX BINDING 8 935 0.0001358 0.004851
27 PROTEIN HOMODIMERIZATION ACTIVITY 7 722 0.0001781 0.006053
28 COLLAGEN BINDING 3 65 0.0001824 0.006053
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 18 1376 8.179e-13 4.777e-10
2 EXTRACELLULAR MATRIX 9 426 2.714e-08 7.925e-06
3 PLATELET ALPHA GRANULE 5 75 1.656e-07 3.223e-05
4 PLASMA MEMBRANE RECEPTOR COMPLEX 6 175 4.52e-07 6.599e-05
5 RECEPTOR COMPLEX 7 327 1.078e-06 0.000126
6 PLATELET ALPHA GRANULE LUMEN 4 55 2.232e-06 0.0002173
7 CELL SURFACE 9 757 3.404e-06 0.000284
8 SECRETORY GRANULE LUMEN 4 85 1.278e-05 0.0009332
9 PROTEIN KINASE COMPLEX 4 90 1.604e-05 0.001041
10 PLASMA MEMBRANE PROTEIN COMPLEX 7 510 1.991e-05 0.001163
11 VESICLE LUMEN 4 106 3.058e-05 0.001624

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04350_TGF.beta_signaling_pathway 34 85 1.087e-84 1.924e-82
2 hsa04340_Hedgehog_signaling_pathway 5 56 3.749e-08 3.318e-06
3 hsa04144_Endocytosis 5 203 2.246e-05 0.001325
4 hsa04380_Osteoclast_differentiation 4 128 6.397e-05 0.002831
5 hsa04510_Focal_adhesion 4 200 0.0003558 0.01189
6 hsa04512_ECM.receptor_interaction 3 85 0.0004031 0.01189
7 hsa04010_MAPK_signaling_pathway 4 268 0.001066 0.02694
8 hsa04110_Cell_cycle 3 128 0.001325 0.02932
9 hsa04145_Phagosome 3 156 0.002333 0.04588
10 hsa04520_Adherens_junction 2 73 0.006836 0.121

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

TRHDE-AS1

 hsa-let-7d-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-331-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-98-5p 10 ACVR1C Sponge network -7.569 0 -5.201 0 0.761
2 MIR143HG hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-340-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -4.451 0 -2.395 0 0.733
3

TRHDE-AS1

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-340-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-93-5p 11 TGFBR2 Sponge network -7.569 0 -2.395 0 0.661
4 ADAMTS9-AS1 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-340-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-93-5p 12 TGFBR2 Sponge network -4.696 0 -2.395 0 0.638
5 LINC00924 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -3.023 0 -2.395 0 0.635
6 RP11-384P7.7 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-340-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -4.533 0 -2.395 0 0.62
7 AL035610.1 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -6.728 0 -2.395 0 0.608
8 RP11-53O19.1 hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-140-3p;hsa-miR-142-5p;hsa-miR-146b-5p;hsa-miR-23a-3p;hsa-miR-24-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-576-5p 10 BMPR1B Sponge network 1.02 0.004 2.333 0 0.494
9 LINC00504 hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-140-3p;hsa-miR-142-5p;hsa-miR-146b-5p;hsa-miR-23a-3p;hsa-miR-24-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-576-5p 10 BMPR1B Sponge network 0.238 0.45396 2.333 0 0.418
10 LINC01085 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -3.703 0 -2.395 0 0.336

Quest ID: b5f4c975363f91d655b952f40dabbd76