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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-34a-3p ABL2 1.76 0 -0.32 0.04554 mirMAP -0.11 6.0E-5 NA
2 hsa-miR-34a-3p ACSL4 1.76 0 -0.41 0.0792 MirTarget -0.1 0.01388 NA
3 hsa-miR-34a-3p ADAM12 1.76 0 0.88 0.05623 mirMAP -0.37 0 NA
4 hsa-miR-34a-3p ADAMTS15 1.76 0 -2.81 0 mirMAP -0.6 0 NA
5 hsa-miR-34a-3p AK1 1.76 0 -0.4 0.10914 mirMAP -0.17 0.00012 NA
6 hsa-miR-34a-3p ANGPTL1 1.76 0 -4.51 0 MirTarget -0.83 0 NA
7 hsa-miR-34a-3p ANK2 1.76 0 -4.32 0 MirTarget -0.72 0 NA
8 hsa-miR-34a-3p ANTXR2 1.76 0 -2.31 0 MirTarget -0.56 0 NA
9 hsa-miR-34a-3p AQP1 1.76 0 -2.68 0 mirMAP -0.31 0 NA
10 hsa-miR-34a-3p ATP10D 1.76 0 -0.69 0.01004 MirTarget -0.2 2.0E-5 NA
11 hsa-miR-34a-3p C14orf37 1.76 0 -0.9 0.01066 mirMAP -0.31 0 NA
12 hsa-miR-34a-3p C17orf51 1.76 0 -0.68 0.02254 mirMAP -0.13 0.01135 NA
13 hsa-miR-34a-3p C1orf21 1.76 0 -1.51 0 mirMAP -0.22 0 NA
14 hsa-miR-34a-3p CALCRL 1.76 0 -0.67 0.01537 MirTarget -0.17 0.0003 NA
15 hsa-miR-34a-3p CAMK2A 1.76 0 -4.14 0 mirMAP -0.71 0 NA
16 hsa-miR-34a-3p CBX6 1.76 0 -1.54 0 mirMAP -0.11 0.04231 NA
17 hsa-miR-34a-3p CD84 1.76 0 -0.53 0.27947 mirMAP -0.41 0 NA
18 hsa-miR-34a-3p CDK6 1.76 0 -0.77 0.06479 mirMAP -0.38 0 21702042; 26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004
19 hsa-miR-34a-3p CIITA 1.76 0 -0.02 0.95968 mirMAP -0.25 0.00148 NA
20 hsa-miR-34a-3p CLEC5A 1.76 0 2.07 1.0E-5 mirMAP -0.17 0.03298 NA
21 hsa-miR-34a-3p CPS1 1.76 0 -1.12 0.04051 MirTarget -0.26 0.00566 NA
22 hsa-miR-34a-3p CSRP1 1.76 0 -2.62 0 MirTarget -0.42 0 NA
23 hsa-miR-34a-3p CYP26B1 1.76 0 -0.69 0.15191 mirMAP -0.33 6.0E-5 NA
24 hsa-miR-34a-3p CYTIP 1.76 0 -1.07 0.01272 MirTarget -0.37 0 NA
25 hsa-miR-34a-3p DENND5A 1.76 0 -1.19 0 MirTarget -0.21 0 NA
26 hsa-miR-34a-3p DOK6 1.76 0 -3.8 0 mirMAP -0.58 0 NA
27 hsa-miR-34a-3p DPYSL2 1.76 0 -1.76 0 MirTarget -0.35 0 NA
28 hsa-miR-34a-3p DRP2 1.76 0 -1.35 0.00023 mirMAP -0.29 1.0E-5 NA
29 hsa-miR-34a-3p DST 1.76 0 -1.12 9.0E-5 mirMAP -0.15 0.00235 NA
30 hsa-miR-34a-3p DUSP1 1.76 0 -3.47 0 MirTarget -0.38 0 NA
31 hsa-miR-34a-3p ETS1 1.76 0 -0.7 0.00228 MirTarget -0.13 0.00112 NA
32 hsa-miR-34a-3p FMNL3 1.76 0 0.14 0.461 mirMAP -0.1 0.00169 NA
33 hsa-miR-34a-3p FOXP2 1.76 0 -3.99 0 MirTarget -0.62 0 NA
34 hsa-miR-34a-3p FTO 1.76 0 -0.52 0.0001 mirMAP -0.13 0 NA
35 hsa-miR-34a-3p GFOD1 1.76 0 -0.94 0.00661 mirMAP -0.31 0 NA
36 hsa-miR-34a-3p GRIN2A 1.76 0 -3.32 0 mirMAP -0.5 0 NA
37 hsa-miR-34a-3p HUNK 1.76 0 -2.27 1.0E-5 mirMAP -0.34 0.00015 NA
38 hsa-miR-34a-3p JAZF1 1.76 0 -1.92 0 MirTarget -0.4 0 NA
39 hsa-miR-34a-3p JUN 1.76 0 -2.05 0 MirTarget -0.28 0 NA
40 hsa-miR-34a-3p KCNIP3 1.76 0 -1.81 0 mirMAP -0.31 0 NA
41 hsa-miR-34a-3p KCNJ12 1.76 0 -2.26 3.0E-5 mirMAP -0.47 0 NA
42 hsa-miR-34a-3p KIAA1614 1.76 0 -2.01 0 mirMAP -0.33 0 NA
43 hsa-miR-34a-3p KIAA1644 1.76 0 -4.4 0 mirMAP -0.84 0 NA
44 hsa-miR-34a-3p KLF13 1.76 0 -1.16 1.0E-5 mirMAP -0.22 0 NA
45 hsa-miR-34a-3p LONRF2 1.76 0 -3.86 0 mirMAP -0.3 0.01921 NA
46 hsa-miR-34a-3p LRRC4 1.76 0 -1.73 0 MirTarget -0.24 0.00029 NA
47 hsa-miR-34a-3p MAOB 1.76 0 -4.32 0 MirTarget -0.86 0 NA
48 hsa-miR-34a-3p MAP3K2 1.76 0 -0.46 0.01831 mirMAP -0.13 0.00022 NA
49 hsa-miR-34a-3p MEF2D 1.76 0 -1.25 0 MirTarget -0.13 0 NA
50 hsa-miR-34a-3p MITF 1.76 0 -2.11 0 MirTarget -0.44 0 NA
51 hsa-miR-34a-3p MN1 1.76 0 -2.44 0 mirMAP -0.56 0 NA
52 hsa-miR-34a-3p MRC1 1.76 0 -1.55 0.0017 MirTarget -0.45 0 NA
53 hsa-miR-34a-3p MYO9A 1.76 0 -1.3 0 mirMAP -0.19 5.0E-5 NA
54 hsa-miR-34a-3p NFATC2 1.76 0 -2.1 3.0E-5 mirMAP -0.3 0.0006 NA
55 hsa-miR-34a-3p NMT2 1.76 0 -1.14 2.0E-5 MirTarget -0.28 0 NA
56 hsa-miR-34a-3p NTRK2 1.76 0 -3.44 0 mirMAP -0.55 0 NA
57 hsa-miR-34a-3p NTRK3 1.76 0 -5.17 0 mirMAP -0.41 4.0E-5 NA
58 hsa-miR-34a-3p OSBPL10 1.76 0 -1.83 0 mirMAP -0.32 0 NA
59 hsa-miR-34a-3p PALLD 1.76 0 -2.69 0 MirTarget -0.58 0 NA
60 hsa-miR-34a-3p PALM2 1.76 0 0.56 0.12712 mirMAP -0.14 0.02449 NA
61 hsa-miR-34a-3p PCDH17 1.76 0 -0.32 0.27717 MirTarget -0.12 0.01906 NA
62 hsa-miR-34a-3p PLXDC1 1.76 0 0 0.99489 mirMAP -0.17 0.00027 NA
63 hsa-miR-34a-3p PLXDC2 1.76 0 -1.34 0.00065 MirTarget -0.44 0 NA
64 hsa-miR-34a-3p PPARA 1.76 0 -0.91 1.0E-5 mirMAP -0.11 0.0022 NA
65 hsa-miR-34a-3p PPP1R16B 1.76 0 -1.51 0 mirMAP -0.24 1.0E-5 NA
66 hsa-miR-34a-3p PTGS2 1.76 0 -2.9 0 MirTarget -0.27 0.00297 23349340 Furthermore restoration of miR-34a indirectly reduced cyclooxygenase-2 COX-2 expression
67 hsa-miR-34a-3p PTPRD 1.76 0 -3.63 0 mirMAP -0.58 0 NA
68 hsa-miR-34a-3p QKI 1.76 0 -0.46 0.00441 mirMAP -0.11 0.0001 NA
69 hsa-miR-34a-3p RASGRF2 1.76 0 -0.96 0.00295 mirMAP -0.24 1.0E-5 NA
70 hsa-miR-34a-3p RGP1 1.76 0 -0.56 0.02121 mirMAP -0.13 0.00148 NA
71 hsa-miR-34a-3p RIC3 1.76 0 -3.43 0 mirMAP -0.39 7.0E-5 NA
72 hsa-miR-34a-3p RIMBP2 1.76 0 -2.69 0 mirMAP -0.48 0 NA
73 hsa-miR-34a-3p RNF212 1.76 0 -2.79 0 MirTarget -0.43 0 NA
74 hsa-miR-34a-3p RORA 1.76 0 -1.82 0 mirMAP -0.26 0 NA
75 hsa-miR-34a-3p RUNX1T1 1.76 0 -3.29 0 mirMAP -0.6 0 NA
76 hsa-miR-34a-3p RYR2 1.76 0 -3.05 0 MirTarget -0.53 0 NA
77 hsa-miR-34a-3p SCN4B 1.76 0 -2.75 0 mirMAP -0.24 0.00018 NA
78 hsa-miR-34a-3p SCUBE3 1.76 0 -2.48 0 mirMAP -0.36 3.0E-5 NA
79 hsa-miR-34a-3p SEC14L5 1.76 0 -1.96 0 mirMAP -0.2 0.00449 NA
80 hsa-miR-34a-3p SEMA3G 1.76 0 -2.06 0 mirMAP -0.15 0.00658 NA
81 hsa-miR-34a-3p SH3PXD2A 1.76 0 -0.99 1.0E-5 mirMAP -0.12 0.00214 NA
82 hsa-miR-34a-3p SIGLEC1 1.76 0 -0.88 0.05671 mirMAP -0.34 3.0E-5 NA
83 hsa-miR-34a-3p SIRPA 1.76 0 -0.55 0.11927 mirMAP -0.29 0 NA
84 hsa-miR-34a-3p SLC1A2 1.76 0 -1.64 0.00012 mirMAP -0.18 0.01821 NA
85 hsa-miR-34a-3p SORBS3 1.76 0 -0.91 0.00021 mirMAP -0.17 0.0001 NA
86 hsa-miR-34a-3p SSFA2 1.76 0 -0.51 0.04373 MirTarget -0.13 0.00253 NA
87 hsa-miR-34a-3p SULF1 1.76 0 0.17 0.75761 mirMAP -0.5 0 NA
88 hsa-miR-34a-3p SV2B 1.76 0 -2.33 7.0E-5 mirMAP -0.6 0 NA
89 hsa-miR-34a-3p SYT11 1.76 0 -2.12 0 MirTarget -0.41 0 NA
90 hsa-miR-34a-3p TEAD1 1.76 0 -1.49 0 mirMAP -0.2 0 NA
91 hsa-miR-34a-3p TGFBRAP1 1.76 0 -0.03 0.90174 MirTarget -0.11 0.02347 NA
92 hsa-miR-34a-3p TMEM108 1.76 0 -2.78 0 mirMAP -0.62 0 NA
93 hsa-miR-34a-3p TMEM169 1.76 0 0.21 0.60534 MirTarget -0.17 0.02044 NA
94 hsa-miR-34a-3p TMEM176B 1.76 0 -0.97 0.01536 MirTarget -0.28 6.0E-5 NA
95 hsa-miR-34a-3p TMEM47 1.76 0 -1.47 0.00017 MirTarget -0.24 0.00053 NA
96 hsa-miR-34a-3p TMOD2 1.76 0 -1.02 2.0E-5 mirMAP -0.22 0 NA
97 hsa-miR-34a-3p TRAM2 1.76 0 -0.48 0.0152 MirTarget -0.16 0 NA
98 hsa-miR-34a-3p TSPAN18 1.76 0 -2.63 0 mirMAP -0.42 0 NA
99 hsa-miR-34a-3p UBXN7 1.76 0 0 0.99285 mirMAP -0.12 0.00142 NA
100 hsa-miR-34a-3p YAP1 1.76 0 -0.82 8.0E-5 MirTarget -0.17 0 NA
101 hsa-miR-34a-3p ZDHHC15 1.76 0 -2.82 0 MirTarget -0.5 0 NA
102 hsa-miR-34a-3p ZEB1 1.76 0 -2.59 0 MirTarget -0.47 0 26359358 Finally an integral role of miR-34a is discovered as miR-34a mimic potentiates HNK-mediated inhibition of EMT Zeb1 expression and nuclear-localization mammosphere-formation and expression of stemness factors
103 hsa-miR-34a-3p ZFP37 1.76 0 -0.81 0.07019 MirTarget -0.16 0.04088 NA
NumGOOverlapSizeP ValueAdj. P Value
1 RESPONSE TO ACID CHEMICAL 11 319 7.743e-07 0.002568
2 RESPONSE TO OXYGEN CONTAINING COMPOUND 22 1381 1.656e-06 0.002568
3 RESPONSE TO MECHANICAL STIMULUS 9 210 1.398e-06 0.002568
4 CELLULAR RESPONSE TO ACID CHEMICAL 8 175 3.432e-06 0.003993
5 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 15 799 1.427e-05 0.008982
6 CELLULAR RESPONSE TO RETINOIC ACID 5 65 2.123e-05 0.008982
7 BLOOD VESSEL MORPHOGENESIS 10 364 1.853e-05 0.008982
8 REGULATION OF CELL DIFFERENTIATION 21 1492 2.001e-05 0.008982
9 RESPONSE TO RETINOIC ACID 6 107 1.912e-05 0.008982
10 CARDIOVASCULAR SYSTEM DEVELOPMENT 15 788 1.212e-05 0.008982
11 CIRCULATORY SYSTEM DEVELOPMENT 15 788 1.212e-05 0.008982
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cAMP_signaling_pathway_hsa04024 5 198 0.003616 0.1266
2 Ras_signaling_pathway_hsa04014 5 232 0.007018 0.1266
3 ErbB_signaling_pathway_hsa04012 3 85 0.009654 0.1266
4 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.00974 0.1266
5 MAPK_signaling_pathway_hsa04010 5 295 0.01831 0.1904
6 VEGF_signaling_pathway_hsa04370 2 59 0.03716 0.2876
7 Wnt_signaling_pathway_hsa04310 3 146 0.03972 0.2876
8 Mitophagy_animal_hsa04137 2 65 0.04429 0.2876
9 Cellular_senescence_hsa04218 3 160 0.04978 0.2876
10 Calcium_signaling_pathway_hsa04020 3 182 0.06782 0.3527
11 TNF_signaling_pathway_hsa04668 2 108 0.1069 0.5056
12 Apelin_signaling_pathway_hsa04371 2 137 0.1571 0.6526
13 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.1716 0.6526
14 Hippo_signaling_pathway_hsa04390 2 154 0.1882 0.6526
15 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.2051 0.6664
16 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.4205 0.9506
17 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.5437 1

Quest ID: b6435689cee0452335976c10b90761c1